locus-tag class description TL08_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) TL08_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TL08_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase TL08_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) TL08_00025 ENOG4105K7N UPF0232 protein TL08_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TL08_00090 ENOG4105XBB septation inhibitor protein TL08_00095 ENOG4108U4N (sortase) family TL08_00120 ENOG4105D9P serine threonine protein kinase TL08_00125 ENOG4107TPY serine threonine protein kinase TL08_00130 ENOG4105CJN penicillin-binding protein TL08_00145 ENOG4105HZM Fha domain containing protein TL08_00155 ENOG4105TV9 FHA Domain-Containing protein TL08_00170 ENOG4105C75 arginyL-tRNA synthetase TL08_00195 ENOG4108SGK Tetr family transcriptional regulator TL08_00250 ENOG4105C94 Transporter TL08_00255 ENOG4105E90 ABC transporter TL08_00260 ENOG4108IJ8 ABC transporter TL08_00265 ENOG4105E90 ABC transporter TL08_00270 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system TL08_00290 ENOG4107SET aldo keto reductase TL08_00330 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) TL08_00365 ENOG4105VFE sira family TL08_00375 ENOG4105JVQ RNA Polymerase TL08_00380 ENOG4107QN1 sodium solute TL08_00400 ENOG4105DY9 regulatoR TL08_00410 ENOG4108HRK Histidine kinase TL08_00430 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TL08_00490 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr TL08_00495 ENOG4108IND Tetr family transcriptional regulator TL08_00500 ENOG4107YEV ferritin TL08_00505 ENOG4105CEU Arginine dihydrolase TL08_00560 ENOG4105C4M (Ubiquinol oxidase) subunit I TL08_00565 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii TL08_00570 ENOG4108JJ9 ABC, transporter TL08_00600 ENOG4108UVJ appr-1-p processing domain protein TL08_00630 ENOG4106032 Glutathionylspermidine synthase TL08_00635 ENOG4105P3N Membrane TL08_00645 ENOG4108IMY Transcriptional regulator TL08_00660 ENOG4108X4Q Hydrolase TL08_00665 ENOG4105C1B dTDP-glucose 4-6-dehydratase TL08_00705 ENOG410602S Transferase TL08_00710 ENOG4108MKI Glycosyl transferase, family 2 TL08_00725 ENOG4108VC7 Protein of unknown function (DUF2587) TL08_00745 ENOG4105IIU Aminopeptidase TL08_00775 ENOG4105CIH Imidazole acetol-phosphate transaminase TL08_00785 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TL08_00815 ENOG4105CHU acetyl-coa acetyltransferase TL08_00825 ENOG4105EVN Prephenate dehydrogenase TL08_00835 ENOG4108Z6B deaminase TL08_00845 ENOG4105EMN RNA polymerase sigma factor TL08_00860 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) TL08_00890 ENOG410804X Transcriptional regulator TL08_00895 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) TL08_00900 ENOG4107QSI ABC, transporter TL08_00905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TL08_00910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_00925 ENOG4105CPC Aldo Keto reductase TL08_00930 ENOG4105CNV Aldolase TL08_00940 ENOG4108JQ1 Dehydrogenase TL08_00945 ENOG4105CXK mandelate racemase muconate lactonizing TL08_00950 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) TL08_01040 ENOG4105CNN ABC, transporter TL08_01045 ENOG4105C2J ABC transporter TL08_01070 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) TL08_01075 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) TL08_01085 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein TL08_01090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TL08_01095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_01100 ENOG4105C3U ABC transporter TL08_01105 ENOG4108JQ7 (ABC) transporter TL08_01135 ENOG4105CFH Aspartokinase TL08_01150 ENOG4105CH6 catalase TL08_01165 ENOG4108ZHJ Organic hydroperoxide resistance protein TL08_01180 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases TL08_01195 ENOG4105DIN metallophosphoesterase TL08_01205 ENOG4105EXN Sulfate transport protein CysZ TL08_01210 ENOG4105BZ4 penicillin-binding protein TL08_01255 ENOG4105CK5 oxidoreductase TL08_01270 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) TL08_01275 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TL08_01315 ENOG4105D74 hydrolase TL08_01325 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) TL08_01360 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TL08_01395 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate TL08_01400 ENOG4106KNT transcriptional regulator TL08_01425 ENOG4105FQP Beta-lactamase TL08_01430 ENOG4105EHZ conserved protein UCP016719 TL08_01435 ENOG4105D17 glycoside hydrolase, family 3 domain protein TL08_01490 ENOG4108I5C dEAD DEAH box helicase TL08_01495 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for TL08_01505 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TL08_01515 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) TL08_01520 ENOG4107QRG dna polymerase iii TL08_01530 ENOG4105VTR Integrase TL08_01535 ENOG4106CY5 excisionase TL08_01570 ENOG4105E09 nadh pyrophosphatase TL08_01620 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) TL08_01640 ENOG4105F0N pyrophosphate phospho-hydrolase TL08_01655 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TL08_01665 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) TL08_01670 ENOG4105EUJ GTP cyclohydrolase i TL08_01675 ENOG4105EEI dihydropteroate synthase TL08_01715 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) TL08_01720 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) TL08_01725 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) TL08_01730 ENOG4105CRK lysyL-tRNA synthetase TL08_01745 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TL08_01755 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) TL08_01780 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) TL08_01790 ENOG4108VJ1 Transcriptional regulator (CarD family TL08_01795 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) TL08_01800 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TL08_01865 ENOG4105C8N cysteinyl-tRNA synthetase TL08_01875 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TL08_01880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) TL08_01895 ENOG4105DHF Membrane TL08_01910 ENOG4105CC5 ABC transporter TL08_01915 ENOG4105DIK (ABC) transporter TL08_01920 ENOG4105DSE periplasmic solute binding protein TL08_01935 ENOG4108IJ9 (ABC) transporter TL08_01940 ENOG4105EG2 ABC transporter, permease TL08_01945 ENOG4105D56 permease protein TL08_01970 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase TL08_01985 ENOG4105CPC Aldo Keto reductase TL08_01990 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase TL08_01995 ENOG4108JPW Aminotransferase TL08_02000 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) TL08_02005 ENOG4105EV8 ectoine hydroxylase TL08_02010 ENOG41065RQ ADP-ribosylation crystallin J1 TL08_02030 ENOG41073TP transcriptional regulator TL08_02045 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TL08_02050 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) TL08_02055 ENOG4105DWF phosphomethylpyrimidine kinase TL08_02075 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) TL08_02085 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) TL08_02100 ENOG4105VDT -acetyltransferase TL08_02105 ENOG4106T9R serine protease TL08_02110 ENOG4106T9R serine protease TL08_02115 ENOG4106T9R serine protease TL08_02120 ENOG4106T9R serine protease TL08_02125 ENOG4105FDP GntR family transcriptional regulator TL08_02145 ENOG4105D17 glycoside hydrolase, family 3 domain protein TL08_02150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) TL08_02160 ENOG4105BZU Histidine kinase TL08_02165 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_02175 ENOG4105WMR Protein CrcB homolog TL08_02180 ENOG41082CG Protein CrcB homolog TL08_02190 ENOG4105V9F hemagglutinin TL08_02210 ENOG4105XEA Tetr family transcriptional regulator TL08_02230 ENOG4107R4N Cell wall formation (By similarity) TL08_02235 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) TL08_02275 ENOG4105C57 major facilitator superfamily TL08_02280 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) TL08_02285 ENOG4108YZJ Pfam:DUF2596 TL08_02290 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TL08_02295 ENOG4105BZU Histidine kinase TL08_02340 ENOG4108RXW HAD-superfamily subfamily IB hydrolase TL08_02350 ENOG4105C1G acyl-Coa dehydrogenase TL08_02375 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) TL08_02380 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) TL08_02390 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TL08_02395 ENOG4105D52 delta-aminolevulinic acid dehydratase TL08_02425 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase TL08_02430 ENOG4108RH7 phosphoglycerate mutase TL08_02435 ENOG4107ZT5 Thiol disulfide interchange protein TL08_02450 ENOG4107QIV Cytochrome c biogenesis protein TL08_02460 ENOG4105CRE cytochrome C TL08_02480 ENOG4105F7P transcriptional regulator AsnC family TL08_02515 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase TL08_02525 ENOG4108IPT Naphthoate synthase TL08_02530 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) TL08_02545 ENOG4105E4F Isochorismate synthase TL08_02560 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit TL08_02565 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit TL08_02570 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit TL08_02575 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit TL08_02580 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) TL08_02595 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) TL08_02610 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TL08_02615 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain TL08_02620 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TL08_02630 ENOG4107QIZ NADH dehydrogenase TL08_02635 ENOG4108IEH NADH dehydrogenase subunit g TL08_02640 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) TL08_02645 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TL08_02650 ENOG41087XN oxidoreductase TL08_02655 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TL08_02670 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TL08_02690 ENOG4105DQU oxidoreductase, subunit beta TL08_02695 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein TL08_02700 ENOG4105F7P transcriptional regulator AsnC family TL08_02705 ENOG4105CIK Amidinotransferase TL08_02710 ENOG4106F60 Histidine kinase TL08_02715 ENOG4105F44 Two component transcriptional regulator, winged helix family TL08_02730 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TL08_02735 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TL08_02750 ENOG4108DT4 serine threonine protein kinase TL08_02780 ENOG4106JDR secreted TL08_02790 ENOG4105D0M Protease HtpX homolog TL08_02800 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) TL08_02830 ENOG4108VPT UPF0234 protein TL08_02835 ENOG4105BZU Histidine kinase TL08_02850 ENOG4105WDJ 50S ribosomal protein L33 TL08_02855 ENOG410900P UPF0336 protein TL08_02885 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) TL08_02895 ENOG4108VZM 50s ribosomal protein L10 TL08_02900 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) TL08_02905 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TL08_02910 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TL08_02930 ENOG4105CJ1 ABC, transporter TL08_02955 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) TL08_02960 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) TL08_02965 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TL08_02975 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) TL08_02985 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) TL08_02990 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) TL08_02995 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) TL08_03000 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity TL08_03005 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) TL08_03010 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) TL08_03015 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) TL08_03020 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) TL08_03025 ENOG41082SA 50s ribosomal protein l29 TL08_03030 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal TL08_03035 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) TL08_03040 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) TL08_03045 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits TL08_03050 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) TL08_03055 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) TL08_03060 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) TL08_03070 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) TL08_03075 ENOG410849U 50S ribosomal protein L30 TL08_03080 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) TL08_03095 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) TL08_03120 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits TL08_03125 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) TL08_03130 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) TL08_03135 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TL08_03140 ENOG4108ZT0 50S ribosomal protein l17 TL08_03145 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TL08_03155 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_03180 ENOG4105DUM transcriptional regulator, lysR family TL08_03200 ENOG4105BZU Histidine kinase TL08_03210 ENOG4105EN6 Membrane TL08_03215 ENOG4105ETX regulatoR TL08_03220 ENOG41062D9 Histidine kinase TL08_03230 ENOG4105C0H protease TL08_03235 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TL08_03250 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) TL08_03265 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase TL08_03270 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase TL08_03280 ENOG4105D9U N-acetyltransferase TL08_03370 ENOG4105FQP Beta-lactamase TL08_03375 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) TL08_03385 ENOG4106F60 Histidine kinase TL08_03390 ENOG4105F44 Two component transcriptional regulator, winged helix family TL08_03425 ENOG4105YVS arsR family transcriptional regulator TL08_03435 ENOG4107QM2 Aldo Keto reductase TL08_03460 ENOG4105GMT ATPase associated with various cellular activities aaa_5 TL08_03485 ENOG4105BZU Histidine kinase TL08_03490 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_03505 ENOG4105CRQ synthase (Component I) TL08_03515 ENOG4105CJ1 ABC, transporter TL08_03530 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) TL08_03535 ENOG4105F8V Hydrolase, tatD family TL08_03540 ENOG4105MS9 Resuscitation-promoting factor TL08_03545 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) TL08_03565 ENOG4105MKU Transcriptional regulator TL08_03615 ENOG4108KPJ rna polymerase sigma factor TL08_03625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TL08_03630 ENOG4108UMI ABC transporter, permease TL08_03635 ENOG4105D01 (LipO)protein TL08_03640 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) TL08_03655 ENOG4105C5H ABC transporter TL08_03680 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) TL08_03685 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) TL08_03700 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) TL08_03705 ENOG4105BZU Histidine kinase TL08_03720 ENOG41067SE Tetr family transcriptional regulator TL08_03745 ENOG4107RE3 peptidase, S41 TL08_03770 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) TL08_03820 ENOG4105CEP NADH dehydrogenase TL08_03860 ENOG4105CHU acetyl-coa acetyltransferase TL08_03885 ENOG4107HP6 Transcriptional regulator TL08_03900 ENOG4107FKK extracellular solute-binding protein family 1 TL08_03905 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component TL08_03910 ENOG4105DRS transport system, permease TL08_03925 ENOG4105CXK mandelate racemase muconate lactonizing TL08_03980 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein TL08_03995 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) TL08_04000 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein TL08_04010 ENOG4105C7B Threonine dehydratase TL08_04025 ENOG41086D8 Transcriptional regulator TL08_04030 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase TL08_04045 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) TL08_04070 ENOG4107S1Q Phosphatase TL08_04085 ENOG4108J20 pectate lyase TL08_04100 ENOG4105C7Z Conserved Protein TL08_04125 ENOG4108IAB Phoh family TL08_04135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TL08_04145 ENOG4107VXM glycerophosphoryl diester phosphodiesterase TL08_04150 ENOG4105C9Q fumarate hydratase class II TL08_04155 ENOG4105CAY ferredoxin--nadp reductase TL08_04200 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TL08_04210 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) TL08_04230 ENOG4105EYH Exonuclease TL08_04240 ENOG4105C3G gtp-binding protein TL08_04265 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) TL08_04275 ENOG4108RZE Tetr family transcriptional regulator TL08_04280 ENOG4108TKH Nitroreductase TL08_04370 ENOG410842T Pterin carbinolamine dehydratase TL08_04380 ENOG4105E0C molybdate abc transporter TL08_04385 ENOG4108UCS ABC, transporter TL08_04395 ENOG4105CJ1 ABC, transporter TL08_04405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TL08_04420 ENOG4105CI3 gtp-binding protein typa TL08_04425 ENOG4107USK Extracellular solute-binding protein, family 5 TL08_04430 ENOG4107USK Extracellular solute-binding protein, family 5 TL08_04440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_04450 ENOG4108JQ7 (ABC) transporter TL08_04455 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) TL08_04465 ENOG4108Z4U Ferredoxin TL08_04475 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) TL08_04490 ENOG4107R4C succinyl-diaminopimelate desuccinylase TL08_04510 ENOG4105CS1 NAD(P)H quinone oxidoreductase TL08_04515 ENOG4108URH decarboxylase TL08_04520 ENOG4105EEI dihydropteroate synthase TL08_04600 ENOG4108UKI Enoyl-CoA hydratase TL08_04615 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TL08_04620 ENOG4105DDW LysR family Transcriptional regulator TL08_04625 ENOG4105D94 Major Facilitator Superfamily TL08_04630 ENOG4107QPH glycogen) synthase TL08_04635 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TL08_04640 ENOG4107ZBN O-methyltransferase TL08_04645 ENOG4105DU6 RNA polymerase TL08_04655 ENOG4105C0H protease TL08_04660 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) TL08_04715 ENOG4105D7N magnesium and cobalt transport protein CorA TL08_04735 ENOG4105DB7 PHP domain protein TL08_04760 ENOG4105C1J atp-dependent rna helicase TL08_04780 ENOG4106HB6 Alpha beta hydrolase TL08_04810 ENOG4105EXQ uroporphyrinogen iii synthase hem4 TL08_04820 ENOG4105C4R Atp-dependent dna helicase TL08_04825 ENOG4105C4R Atp-dependent dna helicase TL08_04840 ENOG4107SVH Potassium channel protein TL08_04865 ENOG4105C1V Peptidase, M16 TL08_04890 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) TL08_04925 ENOG41063PX domain protein TL08_04935 ENOG4105DJZ UPF0182 protein TL08_04955 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) TL08_04960 ENOG4105CAK Cell division ATP-binding protein ftsE TL08_04965 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) TL08_04970 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) TL08_04985 ENOG4108TKH Nitroreductase TL08_05025 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TL08_05100 ENOG4105CVR type I restriction-modification system TL08_05120 ENOG41082YX Transcriptional regulator, arsr family TL08_05125 ENOG4107T5V SNARE associated Golgi TL08_05130 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_05135 ENOG4105BZU Histidine kinase TL08_05145 ENOG4105CGH 5'-nucleotidase TL08_05150 ENOG4105CQ7 ATP-dependent helicase TL08_05155 ENOG4107RGD Major Facilitator superfamily TL08_05170 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr TL08_05195 ENOG4105F27 Major Facilitator TL08_05200 ENOG4105CHR reductase TL08_05215 ENOG4108BT0 50S ribosomal protein L32 TL08_05220 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_05240 ENOG4105CHJ isochorismatase hydrolase TL08_05245 ENOG4105CN8 Transcriptional regulator TL08_05265 ENOG4107UAX integral membrane protein TL08_05270 ENOG4105C37 (CBS) domain TL08_05275 ENOG4105EMU Dehydrogenase TL08_05320 ENOG4105CIG ABC transporter TL08_05350 ENOG4105CPC Aldo Keto reductase TL08_05360 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TL08_05365 ENOG4105PDP Short chain dehydrogenase TL08_05400 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein TL08_05420 ENOG4105C57 major facilitator superfamily TL08_05430 ENOG4105DQ4 alcohol dehydrogenase TL08_05440 ENOG4105CPQ Dehydrogenase TL08_05465 ENOG4105C26 Dehydrogenase TL08_05495 ENOG4108M15 ABC transporter TL08_05530 ENOG4108KXV response regulator TL08_05535 ENOG41065SU Two-component system sensor kinase TL08_05545 ENOG4105EXC Acyl-transferase TL08_05555 ENOG4105DND Transcriptional regulator TL08_05565 ENOG4105CPU Monooxygenase TL08_05575 ENOG4106NZI LysR family Transcriptional regulator TL08_05585 ENOG4105CHP RNA polymerase TL08_05600 ENOG4108JJB ABC transporter TL08_05620 ENOG4105ETE Transcriptional regulator (LacI family TL08_05645 ENOG41087PP glycosyltransferase MGT family TL08_05655 ENOG4105GFG DUF218 domain TL08_05675 ENOG4105CHR reductase TL08_05685 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) TL08_05690 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) TL08_05710 ENOG4105D74 hydrolase TL08_05720 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) TL08_05745 ENOG4105CJ1 ABC, transporter TL08_05750 ENOG41090VJ ABC-2 type transporter TL08_05755 ENOG4108KYE ABC-2 type transporter TL08_05810 ENOG4105CPT Alpha beta hydrolase TL08_05820 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_05830 ENOG4108KDT Molybdate metabolism regulator TL08_05835 ENOG4105CIR epoxide hydrolase TL08_05870 ENOG4105DXX methyltransferase TL08_05900 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TL08_05925 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TL08_05970 ENOG4105VPX protein, conserved in bacteria TL08_06005 ENOG4108UW5 maltose o-acetyltransferase TL08_06010 ENOG4108IG5 Transcriptional regulator TL08_06015 ENOG4105C57 major facilitator superfamily TL08_06025 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) TL08_06040 ENOG4107Z6X Transcriptional regulator TL08_06045 ENOG4105F1N DNA alkylation repair TL08_06060 ENOG4107T6F Xaa-Pro aminopeptidase TL08_06070 ENOG4105CHH sulfate transporter TL08_06085 ENOG4108IND Tetr family transcriptional regulator TL08_06090 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr TL08_06170 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) TL08_06175 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid TL08_06185 ENOG4108VHT MarR family transcriptional regulator TL08_06205 ENOG4105S7S phosphonate abc transporter TL08_06210 ENOG4105D5T phosphonate abc transporter TL08_06215 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein TL08_06225 ENOG4108TZY GntR Family Transcriptional Regulator TL08_06230 ENOG4105CPQ Dehydrogenase TL08_06250 ENOG4107SQI penicillin amidase TL08_06260 ENOG4108T5E Copper resistance protein TL08_06310 ENOG4108M1A Chitin-binding protein TL08_06350 ENOG4105DVC DnaJ domain protein TL08_06355 ENOG4105BZU Histidine kinase TL08_06370 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TL08_06375 ENOG4107R34 abc transporter permease protein TL08_06385 ENOG4107YPT transcriptional regulator TL08_06415 ENOG4105BZU Histidine kinase TL08_06430 ENOG4105EAC phosphoserine phosphatase TL08_06450 ENOG4108RWI nicotinamidase TL08_06460 ENOG4105CPQ Dehydrogenase TL08_06470 ENOG4107RKP Nicotinate phosphoribosyltransferase TL08_06475 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) TL08_06485 ENOG4105KXX peptidase s58 dmpa TL08_06530 ENOG4105D7N magnesium and cobalt transport protein CorA TL08_06535 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) TL08_06540 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TL08_06555 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) TL08_06560 ENOG4105DR5 peptidase TL08_06605 ENOG4105DKW ABC transporter TL08_06610 ENOG4105UPE Enoyl-CoA hydratase TL08_06625 ENOG4105EVB acetyltransferase TL08_06650 ENOG4108KQJ Type 11 methyltransferase TL08_06680 ENOG4105C10 Electron transfer flavoprotein TL08_06690 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) TL08_06705 ENOG41083PU Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TL08_06715 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TL08_06730 ENOG4105CEY Amp-dependent synthetase and ligase TL08_06755 ENOG4105H3G oxidoreductase TL08_06770 ENOG4105VQD rieske 2fe-2S domain-containing protein TL08_06775 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region TL08_06785 ENOG4105DVW rieske (2Fe-2S) TL08_06795 ENOG41065HY 1,4-beta-cellobiosidase TL08_06825 ENOG4105BZU Histidine kinase TL08_06830 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_06835 ENOG41088PD hydrolase TL08_06840 ENOG4105VDT -acetyltransferase TL08_06895 ENOG4107UBC ErfK ybiS ycfS ynhG family protein TL08_06905 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) TL08_06915 ENOG4105E1F short-chain dehydrogenase reductase TL08_06925 ENOG4105CIR epoxide hydrolase TL08_06930 ENOG4105EMN RNA polymerase sigma factor TL08_06950 ENOG4105DA5 (ABC) transporter TL08_06975 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) TL08_07015 ENOG4105XYF acetyltransferase TL08_07065 ENOG4108JNI Alpha beta hydrolase TL08_07090 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_07165 ENOG4108URH decarboxylase TL08_07170 ENOG4105C2C drug resistance transporter, Bcr CflA TL08_07190 ENOG4105D82 Glutamate dehydrogenase TL08_07195 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) TL08_07230 ENOG4105C75 arginyL-tRNA synthetase TL08_07235 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) TL08_07240 ENOG4105D6E homoserine dehydrogenase TL08_07245 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) TL08_07250 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) TL08_07255 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TL08_07255 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TL08_07265 ENOG4105VFB Binds the 23S rRNA (By similarity) TL08_07270 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) TL08_07280 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) TL08_07290 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) TL08_07295 ENOG4105ESV Glycosyl transferase, family 4 TL08_07305 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) TL08_07315 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) TL08_07320 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) TL08_07325 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) TL08_07330 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) TL08_07335 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) TL08_07360 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TL08_07375 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TL08_07405 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin TL08_07410 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) TL08_07435 ENOG4105CMT Dihydroxyacetone kinase TL08_07440 ENOG4108UTZ Dihydroxyacetone kinase TL08_07460 ENOG4108ZVT methylmalonyl-coA epimerase TL08_07470 ENOG4105CHU acetyl-coa acetyltransferase TL08_07485 ENOG4105EYF MMPL domain protein TL08_07490 ENOG41067TZ transcriptional regulator, MarR family TL08_07525 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) TL08_07530 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) TL08_07545 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) TL08_07585 ENOG4105FKQ transcriptional regulator TL08_07605 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component TL08_07620 ENOG4105MHT Transcriptional regulator, ARSR family TL08_07635 ENOG4105EBR Carboxylesterase TL08_07720 ENOG4105DEN Luciferase family TL08_07745 ENOG4106F60 Histidine kinase TL08_07750 ENOG4105F44 Two component transcriptional regulator, winged helix family TL08_07765 ENOG4105DEN Luciferase family TL08_07775 ENOG4105EUB pirin domain protein TL08_07800 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_07810 ENOG4106JDR secreted TL08_07840 ENOG4105C7I Dehydrogenase TL08_07855 ENOG4105CG3 alpha amylase, catalytic region TL08_07865 ENOG4105D8X mechanosensitive ion channel TL08_07915 ENOG4109057 TL08_07925 ENOG4105MC2 DSBA oxidoreductase TL08_08005 ENOG4107QRI Phosphoketolase TL08_08035 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase TL08_08045 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation TL08_08050 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TL08_08055 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TL08_08060 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) TL08_08075 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) TL08_08100 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TL08_08105 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase TL08_08115 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) TL08_08120 ENOG4105CJ1 ABC, transporter TL08_08130 ENOG4105HAC ABC-2 type transporter TL08_08140 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) TL08_08155 ENOG4105C03 ribonuclease TL08_08155 ENOG4105C03 ribonuclease TL08_08160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TL08_08180 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) TL08_08185 ENOG4105K46 50S ribosomal protein l27 TL08_08190 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TL08_08195 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) TL08_08205 ENOG4105C9U ATP-dependent DNA helicase RecQ TL08_08210 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) TL08_08225 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) TL08_08230 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) TL08_08235 ENOG4105CVJ phosphoglycerate mutase TL08_08240 ENOG4108TZC TL08_08245 ENOG4105EPR degv family TL08_08250 ENOG4105KQC Competence protein TL08_08270 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) TL08_08285 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) TL08_08310 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) TL08_08315 ENOG4105CEY Amp-dependent synthetase and ligase TL08_08330 ENOG4108RVA ribokinase TL08_08335 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) TL08_08360 ENOG4105C2J ABC transporter TL08_08365 ENOG4108HWW ABC transporter TL08_08370 ENOG4105E2R ROK family TL08_08385 ENOG4105DFK Polyphosphate glucokinase TL08_08410 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) TL08_08435 ENOG4107VEG TrkA-N domain protein TL08_08440 ENOG4105C0X amino acid TL08_08445 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TL08_08450 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) TL08_08455 ENOG4105F44 Two component transcriptional regulator, winged helix family TL08_08460 ENOG4106F60 Histidine kinase TL08_08475 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) TL08_08480 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) TL08_08485 ENOG4105KC9 Modulates RecA activity (By similarity) TL08_08495 ENOG4108UHU Aldolase TL08_08500 ENOG4105C01 Dihydroxy-acid dehydratase TL08_08515 ENOG4105DRP amino acid AbC transporter TL08_08520 ENOG4105E5Q amino acid AbC transporter TL08_08525 ENOG4107UBR Extracellular solute-binding protein family 3 TL08_08530 ENOG4105CDA abc transporter atp-binding protein TL08_08535 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TL08_08545 ENOG4105C99 atpase involved in dna repair TL08_08555 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TL08_08560 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) TL08_08570 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) TL08_08580 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) TL08_08590 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) TL08_08595 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TL08_08605 ENOG4105CYP glycoside hydrolase, family TL08_08640 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) TL08_08645 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) TL08_08655 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein TL08_08665 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) TL08_08675 ENOG4105KHC sulfurtransferase TL08_08685 ENOG4105DGU Histone deacetylase TL08_08690 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain TL08_08700 ENOG4105BZU Histidine kinase TL08_08705 ENOG4108KXV response regulator TL08_08715 ENOG4105C6Z Gluconate TL08_08720 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family TL08_08760 ENOG4105K5M 30s ribosomal protein S16 TL08_08770 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) TL08_08775 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) TL08_08780 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) TL08_08785 ENOG4107QYR Signal peptidase i TL08_08790 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TL08_08810 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TL08_08815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_08825 ENOG4108JQ6 ABC transporter TL08_08835 ENOG4105DKQ ROK family TL08_08840 ENOG41080R2 UPF0102 protein TL08_08845 ENOG4105C0P Mg chelatase subunit ChlI TL08_08855 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TL08_08860 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TL08_08870 ENOG4105CE9 30S ribosomal protein S2 TL08_08875 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) TL08_08880 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) TL08_08885 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) TL08_08895 ENOG41089UC methyltransferase, type 11 TL08_08900 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs TL08_08910 ENOG41068X0 Protein of unknown function (DUF2631) TL08_08915 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TL08_08920 ENOG4108HM4 ABC transporter TL08_08925 ENOG4105F38 ABC transporter, permease TL08_08930 ENOG4105D38 putrescine abc transporter TL08_08935 ENOG4105Y3U Transglycosylase-associated protein TL08_08940 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) TL08_08950 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) TL08_08955 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) TL08_08975 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) TL08_09000 ENOG4105C6F GntR Family Transcriptional Regulator TL08_09025 ENOG4108V1U phospholipid-binding protein TL08_09035 ENOG4105BZU Histidine kinase TL08_09040 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_09060 ENOG4105W1N transcriptional regulator TL08_09065 ENOG4108RWP Major Facilitator Superfamily protein TL08_09075 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap TL08_09085 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TL08_09090 ENOG4106A3M Cytochrome p-450 TL08_09100 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TL08_09105 ENOG4105C1J atp-dependent rna helicase TL08_09115 ENOG4107XFJ UPF0246 protein TL08_09125 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) TL08_09135 ENOG4105DEN Luciferase family TL08_09165 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) TL08_09180 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) TL08_09190 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) TL08_09195 ENOG41061TZ Short-chain dehydrogenase reductase Sdr TL08_09200 ENOG41080VW acetyltransferase TL08_09230 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) TL08_09265 ENOG4107QZF nitrite reductase NADPH large subunit TL08_09270 ENOG4105DQQ Major facilitator superfamily MFS_1 TL08_09275 ENOG4108IFG nitrite reductase, (NAD(P)H) TL08_09280 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) TL08_09285 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) TL08_09290 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) TL08_09295 ENOG4105C1V Peptidase, M16 TL08_09300 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) TL08_09335 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) TL08_09340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TL08_09345 ENOG4105CN5 Metallo-Beta-Lactamase TL08_09350 ENOG4107QZI cell division protein FtsK TL08_09370 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) TL08_09380 ENOG4105CEV competence damage-inducible protein TL08_09385 ENOG4105WBV Transcriptional regulator TL08_09405 ENOG4105C2W permease TL08_09410 ENOG4107QJE Chromosome Partitioning Protein TL08_09435 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TL08_09440 ENOG4108V6E Cell division protein mraZ TL08_09445 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) TL08_09455 ENOG4105CJN penicillin-binding protein TL08_09470 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) TL08_09490 ENOG4105DFU Cell wall formation (By similarity) TL08_09495 ENOG4105ME9 cell division protein FtsQ TL08_09500 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone TL08_09510 ENOG4107R7A Allophanate hydrolase subunit 2 TL08_09520 ENOG4105E7W lamb ycsf family protein TL08_09525 ENOG4105CMG Carbohydrate kinase TL08_09540 ENOG4105DFA alanine racemase domain protein TL08_09545 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) TL08_09560 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TL08_09605 ENOG4106A3M Cytochrome p-450 TL08_09610 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TL08_09615 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) TL08_09625 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) TL08_09645 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) TL08_09650 ENOG4108IYU L-aspartate oxidase TL08_09680 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) TL08_09685 ENOG4105CIH Imidazole acetol-phosphate transaminase TL08_09700 ENOG4108KPJ rna polymerase sigma factor TL08_09705 ENOG4105ECC imidazole-glycerol-phosphate dehydratase TL08_09715 ENOG4108Z4X TRANSCRIPTIONal TL08_09720 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) TL08_09730 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase TL08_09745 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) TL08_09755 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase TL08_09760 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) TL08_09765 ENOG4105CRQ synthase (Component I) TL08_09780 ENOG4105DK0 Indole-3-glycerol phosphate synthase TL08_09785 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) TL08_09790 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) TL08_09800 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) TL08_09805 ENOG4105CAT Cytidine monophosphate kinase TL08_09815 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) TL08_09825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TL08_09830 ENOG4105JHE Major Facilitator Superfamily TL08_09835 ENOG4105CZE histidine utilization repressor TL08_09840 ENOG4107TEJ This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) TL08_09845 ENOG4105N14 lysine exporter protein LysE YggA TL08_09850 ENOG4105F7P transcriptional regulator AsnC family TL08_09900 ENOG4105DIA mandelate racemase muconate lactonizing TL08_09905 ENOG4105ERH Fumarylacetoacetate hydrolase TL08_09930 ENOG4105CHP RNA polymerase TL08_09945 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) TL08_09950 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase TL08_09960 ENOG4105E4C Lytic transglycosylase catalytic TL08_09970 ENOG4105EW9 transcriptional regulator AsnC family TL08_10025 ENOG4105C31 Tryptophanyl-tRNA synthetase TL08_10030 ENOG4105WCJ ec 1.1.1.193 TL08_10055 ENOG4106T9R serine protease TL08_10090 ENOG4105C9U ATP-dependent DNA helicase RecQ TL08_10095 ENOG4108ZHJ Organic hydroperoxide resistance protein TL08_10150 ENOG4105CNU cell division protein FtsK TL08_10195 ENOG4105C32 Amino acid ABC transporter (Permease) TL08_10200 ENOG4105CF8 branched-chain amino acid ABC transporter, permease TL08_10205 ENOG4105C0Z ABC transporter TL08_10210 ENOG4108IV0 ABC, transporter TL08_10215 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) TL08_10225 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase TL08_10245 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) TL08_10250 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) TL08_10255 ENOG4105EXC Acyl-transferase TL08_10260 ENOG4105EXC Acyl-transferase TL08_10265 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) TL08_10305 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein TL08_10335 ENOG4105C22 threonyL-tRNA synthetase TL08_10350 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase TL08_10360 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) TL08_10375 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) TL08_10380 ENOG4108IMY Transcriptional regulator TL08_10395 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) TL08_10400 ENOG4105CDY transcriptional regulatory protein TL08_10420 ENOG4105DUX Transporter TL08_10425 ENOG4105CHR reductase TL08_10435 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TL08_10475 ENOG4106ARF phosphopantetheine-binding protein TL08_10485 ENOG4107EXU Short-chain dehydrogenase reductase Sdr TL08_10510 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) TL08_10515 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) TL08_10520 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) TL08_10530 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) TL08_10535 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) TL08_10580 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) TL08_10585 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) TL08_10625 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap TL08_10635 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TL08_10640 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TL08_10645 ENOG4107SIG periplasmic solute binding protein TL08_10650 ENOG4105DIK (ABC) transporter TL08_10655 ENOG4107RPQ ABC transporter TL08_10660 ENOG4107RBD ABC, transporter TL08_10665 ENOG4107STQ Multicopper oxidase TL08_10685 ENOG4108S4H thioesterase Superfamily protein TL08_10705 ENOG4105F76 Sarcosine oxidase TL08_10745 ENOG4108UW8 fha domain-containing protein TL08_10765 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TL08_10770 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) TL08_10795 ENOG4108Q5F Tetr family transcriptional regulator TL08_10800 ENOG4105D1K glutamate--cysteine ligase TL08_10805 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process TL08_10810 ENOG4108V75 Glutamine amidotransferase TL08_10815 ENOG41067HS methyltransferase TL08_10835 ENOG4107QM5 aconitate hydratase TL08_10850 ENOG4105ZXU NLP P60 protein TL08_10860 ENOG4107RSM transcriptional regulator TL08_10865 ENOG4105FDR Membrane TL08_10875 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TL08_10890 ENOG4105CHR reductase TL08_10895 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH TL08_10900 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) TL08_10910 ENOG4108UF8 TL08_10935 ENOG4105C26 Dehydrogenase TL08_10955 ENOG4105DV0 amidase (EC 3.5.1.4 TL08_10980 ENOG41073TP transcriptional regulator TL08_10990 ENOG4108JPW Aminotransferase TL08_11000 ENOG4105CT1 (ABC) transporter TL08_11015 ENOG4105D9P serine threonine protein kinase TL08_11025 ENOG4107U9H DNA polymerase TL08_11030 ENOG4105CHU acetyl-coa acetyltransferase TL08_11035 ENOG4105EE5 Membrane protein terC TL08_11050 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase TL08_11055 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) TL08_11100 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) TL08_11165 ENOG4105JXH GntR family transcriptional regulator TL08_11170 ENOG4105CX8 fg-gap repeat protein TL08_11235 ENOG4105CPP Dehydrogenase, E1 component TL08_11240 ENOG4108JYK Dehydrogenase TL08_11265 ENOG4105CQ7 ATP-dependent helicase TL08_11305 ENOG4105C9M aspartyl-trna synthetase TL08_11315 ENOG41082W1 Cupin 2, conserved barrel domain protein TL08_11360 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TL08_11380 ENOG4105E2X shikimate dehydrogenase TL08_11395 ENOG4105FDP GntR family transcriptional regulator TL08_11405 ENOG4105C5Y PTS System TL08_11415 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase TL08_11420 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) TL08_11430 ENOG4105D49 3-dehydroquinate synthase TL08_11435 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) TL08_11450 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) TL08_11455 ENOG4105DC7 peptidase M24 TL08_11460 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) TL08_11465 ENOG410803B Involved in the transcription termination process (By similarity) TL08_11480 ENOG4105CXT aspartate transcarbamylase TL08_11495 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain TL08_11505 ENOG4105SKN orotidine 5''-phosphate decarboxylase TL08_11515 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) TL08_11520 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) TL08_11530 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP TL08_11550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) TL08_11565 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) TL08_11570 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TL08_11585 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) TL08_11590 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) TL08_11605 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TL08_11610 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) TL08_11620 ENOG4105CIE May be required for sporulation (By similarity) TL08_11625 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase TL08_11630 ENOG4105BZA Phosphoglycerate kinase TL08_11635 ENOG4105CP7 Triose-phosphate isomerase TL08_11650 ENOG4108KPJ rna polymerase sigma factor TL08_11655 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) TL08_11660 ENOG4105DTD Dehydrogenase TL08_11675 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) TL08_11690 ENOG4107QP8 phosphohexose isomerase TL08_11695 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) TL08_11705 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) TL08_11730 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein TL08_11750 ENOG4105CJ1 ABC, transporter TL08_11755 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_11760 ENOG4105BZU Histidine kinase TL08_11775 ENOG410600Z Regulatory protein MarR TL08_11790 ENOG4105CJ1 ABC, transporter TL08_11795 ENOG4107JC6 Membrane TL08_11820 ENOG4105C3K feS assembly ATPase SufC TL08_11830 ENOG4108UNV SUF system FeS assembly protein, NifU family TL08_11835 ENOG4105VG1 fes assembly suf system protein TL08_11850 ENOG4105BZU Histidine kinase TL08_11860 ENOG4105EBR Carboxylesterase TL08_11875 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein TL08_11890 ENOG4105C5H ABC transporter TL08_11900 ENOG4105CGU Enoyl-CoA hydratase TL08_11910 ENOG4105KVH Transcriptional regulator TL08_11935 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TL08_11945 ENOG4108478 ec 3.2.1.18 TL08_11955 ENOG4105EAH synthase TL08_11960 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) TL08_11965 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase TL08_11970 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) TL08_11975 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) TL08_12005 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) TL08_12040 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) TL08_12055 ENOG4105E5F proteasome TL08_12060 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) TL08_12065 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) TL08_12070 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) TL08_12085 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) TL08_12095 ENOG4107TMB Transcriptional regulator TL08_12125 ENOG4105HHS UPF0256 protein TL08_12140 ENOG4105J0Q Transcriptional regulator TL08_12155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TL08_12160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TL08_12170 ENOG4105FS0 cytoplasmic membrane protein TL08_12190 ENOG4107NHD transcriptional regulator TL08_12240 ENOG4105BZ1 (ABC) transporter TL08_12285 ENOG4105D9P serine threonine protein kinase TL08_12295 ENOG4105DQE DNA ligase TL08_12300 ENOG4105DQE DNA ligase TL08_12310 ENOG4105CH6 catalase TL08_12320 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) TL08_12330 ENOG4105C09 Bile acid TL08_12350 ENOG4105DQ5 transport system permease protein TL08_12355 ENOG4105TVJ transport system, permease TL08_12360 ENOG4105E0A ABC, transporter TL08_12365 ENOG4105BZ1 (ABC) transporter TL08_12370 ENOG4105BZ1 (ABC) transporter TL08_12385 ENOG4105EKC TL08_12405 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) TL08_12410 ENOG4108IG5 Transcriptional regulator TL08_12430 ENOG4105FCA ABC transporter periplasmic-binding protein YphF TL08_12435 ENOG4108F37 ATP-binding component of a transport system TL08_12440 ENOG4105CNN ABC, transporter TL08_12445 ENOG4105CPQ Dehydrogenase TL08_12460 ENOG4107EJG GntR family transcriptional regulator TL08_12465 ENOG4105CXK mandelate racemase muconate lactonizing TL08_12470 ENOG4108UHU Aldolase TL08_12475 ENOG4105D7K pfkb domain protein TL08_12500 ENOG4107YUH hydrolase TL08_12505 ENOG4107SQD Transcriptional regulator, GntR family TL08_12525 ENOG4105C6X Major Facilitator TL08_12545 ENOG4105C1G acyl-Coa dehydrogenase TL08_12550 ENOG4105CHR reductase TL08_12555 ENOG4105EMU Dehydrogenase TL08_12570 ENOG4108IV0 ABC, transporter TL08_12575 ENOG4105C0Z ABC transporter TL08_12580 ENOG4105C32 Amino acid ABC transporter (Permease) TL08_12585 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane TL08_12595 ENOG4105C1G acyl-Coa dehydrogenase TL08_12600 ENOG4105CEY Amp-dependent synthetase and ligase TL08_12605 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein TL08_12630 ENOG4105CHU acetyl-coa acetyltransferase TL08_12655 ENOG4105GVF (ABC) transporter TL08_12660 ENOG4105E2Y ABC, transporter TL08_12665 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component TL08_12675 ENOG4105KVH Transcriptional regulator TL08_12690 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) TL08_12700 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) TL08_12705 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) TL08_12710 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) TL08_12715 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) TL08_12725 ENOG4108I5U Uridine phosphorylase TL08_12740 ENOG4108JQ9 ABC transporter TL08_12765 ENOG4105CPU Monooxygenase TL08_12775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_12780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TL08_12785 ENOG4105DEF Extracellular solute-binding protein, family 5 TL08_12790 ENOG4105MXW flavin reductase domain protein, FMN-binding TL08_12795 ENOG4108UZX fmn reductase TL08_12800 ENOG4105YIP Tetr family transcriptional regulator TL08_12825 ENOG4105GWZ Roadblock lc7 family protein TL08_12880 ENOG4105CNN ABC, transporter TL08_12885 ENOG4105C2J ABC transporter TL08_12890 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F TL08_12905 ENOG4105CSH Transporter TL08_12910 ENOG4105C7K acetolactate synthase TL08_12915 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F TL08_12920 ENOG4105FDP GntR family transcriptional regulator TL08_12930 ENOG4105C26 Dehydrogenase TL08_13015 ENOG4108IY8 ABC, transporter TL08_13025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component TL08_13035 ENOG4108Z4X TRANSCRIPTIONal TL08_13055 ENOG4105C0R drug resistance transporter emrb qaca subfamily TL08_13070 ENOG4105DEF Extracellular solute-binding protein, family 5 TL08_13075 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TL08_13080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_13085 ENOG4108JQ6 ABC transporter TL08_13100 ENOG4105VEQ Cold shock protein TL08_13120 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A TL08_13165 ENOG4105EET magnesium chelatase TL08_13190 ENOG4105C8N cysteinyl-tRNA synthetase TL08_13210 ENOG4105C3R Methionine synthase TL08_13215 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 TL08_13220 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone TL08_13225 ENOG4105BZN citrate synthase TL08_13235 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) TL08_13240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TL08_13250 ENOG4105C57 major facilitator superfamily TL08_13255 ENOG4105BZ1 (ABC) transporter TL08_13270 ENOG410769Z extracellular solute-binding protein family 1 TL08_13285 ENOG4105FB2 class II Aldolase TL08_13290 ENOG4105G63 Type III effector Hrp-dependent TL08_13300 ENOG4105C6Z Gluconate TL08_13305 ENOG4105MVE transcriptional regulator TL08_13315 ENOG4105J7D transcriptional regulator TL08_13330 ENOG4105CHH sulfate transporter TL08_13355 ENOG4105F27 Major Facilitator TL08_13370 ENOG4105CVK Glutamate decarboxylase TL08_13395 ENOG4105QE3 oxidoreductase TL08_13410 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) TL08_13555 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein TL08_13560 ENOG4105Q26 Siderophore-interacting protein TL08_13575 ENOG4105CUC YeeE YedE family protein TL08_13590 ENOG4105D01 (LipO)protein TL08_13595 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TL08_13600 ENOG4108UMI ABC transporter, permease TL08_13605 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) TL08_13620 ENOG4108UZX fmn reductase TL08_13625 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone TL08_13650 ENOG4105ETE Transcriptional regulator (LacI family TL08_13655 ENOG4108JE9 extracellular solute-binding protein family 1 TL08_13660 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component TL08_13675 ENOG4105ETE Transcriptional regulator (LacI family TL08_13685 ENOG4107SYN Glycosyl hydrolases family 43 TL08_13695 ENOG4107RTD sua5 ycio yrdc ywlc family protein TL08_13700 ENOG4105E0A ABC, transporter TL08_13705 ENOG4105TVJ transport system, permease TL08_13710 ENOG4105DQ5 transport system permease protein TL08_13735 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family TL08_13740 ENOG4105C5H ABC transporter TL08_13745 ENOG4105CPQ Dehydrogenase TL08_13755 ENOG4105FBA Phospholipase Carboxylesterase TL08_13760 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase TL08_13765 ENOG41090MY MarR family Transcriptional regulator TL08_13770 ENOG4105F32 YngK protein TL08_13785 ENOG4105C6T cysteine synthase TL08_13835 ENOG4105CPC Aldo Keto reductase TL08_13855 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein TL08_13910 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) TL08_13920 ENOG4107W53 thymidine kinase TL08_13940 ENOG4105BZU Histidine kinase TL08_13990 ENOG4105BZ1 (ABC) transporter TL08_14015 ENOG4105C0D helicase TL08_14025 ENOG4105CHR reductase TL08_14035 ENOG4108Z6Z Transcriptional regulator TL08_14050 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TL08_14055 ENOG4108V8F Transcriptional regulator, MarR family TL08_14080 ENOG4105ECR NmrA family TL08_14085 ENOG4105KVH Transcriptional regulator TL08_14110 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) TL08_14115 ENOG4105DDN Pentapeptide repeat-containing protein TL08_14120 ENOG4105YIP Tetr family transcriptional regulator TL08_14150 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) TL08_14155 ENOG4105EBR Carboxylesterase TL08_14170 ENOG4105DR5 peptidase TL08_14185 ENOG4105DV0 amidase (EC 3.5.1.4 TL08_14200 ENOG4105EE1 crotonyl-CoA reductase TL08_14205 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase TL08_14215 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) TL08_14250 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein TL08_14265 ENOG41067TZ transcriptional regulator, MarR family TL08_14270 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TL08_14275 ENOG4105DYW oxidoreductase TL08_14315 ENOG4105KRM Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) TL08_14355 ENOG4107QRT dEAD DEAH box helicase TL08_14435 ENOG4105C0W non-ribosomal peptide synthetase TL08_14445 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase TL08_14525 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_14615 ENOG4105EE1 crotonyl-CoA reductase TL08_14635 ENOG4108YRB methyltransferase TL08_14685 ENOG4105K5B UPF0225 protein TL08_14710 ENOG4105ETE Transcriptional regulator (LacI family TL08_14725 ENOG4105E1F short-chain dehydrogenase reductase TL08_14740 ENOG4105E1F short-chain dehydrogenase reductase TL08_14745 ENOG4108XG4 DNA-binding transcriptional regulator TL08_14750 ENOG4105CTU Proline racemase TL08_14770 ENOG4105MWK D-amino acid dehydrogenase, small subunit TL08_14775 ENOG4105G3Z GntR family transcriptional regulator TL08_14795 ENOG4105C3U ABC transporter TL08_14805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_14810 ENOG4105DEF Extracellular solute-binding protein, family 5 TL08_14890 ENOG4105CEY Amp-dependent synthetase and ligase TL08_14900 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TL08_14910 ENOG4105C6T cysteine synthase TL08_14915 ENOG4105DBV ornithine carbamoyltransferase TL08_14930 ENOG4108X07 Tetr family transcriptional regulator TL08_14935 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) TL08_14940 ENOG4105CX8 fg-gap repeat protein TL08_14955 ENOG4105JSC dimethylmenaquinone methyltransferase TL08_14975 ENOG4107RSM transcriptional regulator TL08_14990 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) TL08_14995 ENOG4105E0T Short-chain dehydrogenase reductase Sdr TL08_15020 ENOG4105ETE Transcriptional regulator (LacI family TL08_15025 ENOG4105C4C beta-galactosidase TL08_15035 ENOG4105DRS transport system, permease TL08_15045 ENOG4105EBR Carboxylesterase TL08_15055 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_15065 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) TL08_15075 ENOG4105EBM Alpha Beta Hydrolase Fold protein TL08_15100 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TL08_15125 ENOG41061TZ Short-chain dehydrogenase reductase Sdr TL08_15140 ENOG4105EPH radical SAM domain protein TL08_15165 ENOG41062B0 ABC transporter, permease TL08_15170 ENOG4107R9N ABC transporter TL08_15175 ENOG4105C2J ABC transporter TL08_15180 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TL08_15190 ENOG4105CNT hydrolase family 2 TL08_15195 ENOG4105E98 transcriptional regulator DeoR family TL08_15205 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_15225 ENOG4107S5I aldo keto reductase TL08_15325 ENOG4105DR5 peptidase TL08_15350 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) TL08_15385 ENOG4107FKK extracellular solute-binding protein family 1 TL08_15390 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component TL08_15400 ENOG4105CXK mandelate racemase muconate lactonizing TL08_15425 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TL08_15430 ENOG4105EMY transcriptional regulator TL08_15435 ENOG4108UZ3 Transporter TL08_15445 ENOG4105ETE Transcriptional regulator (LacI family TL08_15485 ENOG4105DR3 abc transporter permease protein TL08_15490 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component TL08_15500 ENOG4107QK4 glycoside hydrolase, family 3 domain protein TL08_15535 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase TL08_15540 ENOG4105MHT Transcriptional regulator, ARSR family TL08_15550 ENOG41080RH Thioredoxin TL08_15560 ENOG4105RHY Pfam:UPF0157 TL08_15575 ENOG4105C38 Glycyl-tRNA synthetase beta subunit TL08_15590 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) TL08_15595 ENOG4105EHG Permease protein TL08_15610 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TL08_15615 ENOG4105CGD Nad-dependent epimerase dehydratase TL08_15635 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) TL08_15680 ENOG4105G6Z alkaline phosphatase TL08_15690 ENOG4105DXI Major Facilitator superfamily TL08_15720 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) TL08_15730 ENOG4108KDT Molybdate metabolism regulator TL08_15755 ENOG4105DIA mandelate racemase muconate lactonizing TL08_15760 ENOG4105CQB FAD linked oxidase domain protein TL08_15785 ENOG4108S8N class II Aldolase TL08_15825 ENOG4105CEY Amp-dependent synthetase and ligase TL08_15835 ENOG4105T38 integral membrane protein TL08_15905 ENOG4106A3M Cytochrome p-450 TL08_16015 ENOG4105CN2 monooxygenase, FAD-binding TL08_16040 ENOG4107STQ Multicopper oxidase TL08_16060 ENOG4108IUW ABC transporter TL08_16090 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) TL08_16095 ENOG4105EYF MMPL domain protein TL08_16105 ENOG4108Z6Z Transcriptional regulator TL08_16110 ENOG4108IXY short-chain dehydrogenase reductase TL08_16130 ENOG4105CJ1 ABC, transporter TL08_16155 ENOG4105CQB FAD linked oxidase domain protein TL08_16160 ENOG4105DWT malate dehydrogenase (quinone) TL08_16165 ENOG4105DIA mandelate racemase muconate lactonizing TL08_16195 ENOG4105C6N Formate acetyltransferase TL08_16245 ENOG4105EBR Carboxylesterase TL08_16265 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region TL08_16270 ENOG4107R9S Malate synthase TL08_16275 ENOG4108IG5 Transcriptional regulator TL08_16280 ENOG4105C57 major facilitator superfamily TL08_16290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TL08_16295 ENOG4107QZB decarboxylase TL08_16305 ENOG4105CM2 brancheD-chain amino acid aminotransferase TL08_16335 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TL08_16340 ENOG4105CRP Part of the ABC transporter FtsEX involved in TL08_16345 ENOG4105CDH Citrulline--aspartate ligase TL08_16360 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_16385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TL08_16405 ENOG4105CWX Alpha-1,2-mannosidase TL08_16410 ENOG4105C7K acetolactate synthase TL08_16495 ENOG4106UW1 Major Facilitator superfamily TL08_16500 ENOG4108RFG Tetr family transcriptional regulator TL08_16510 ENOG4105DEN Luciferase family TL08_16555 ENOG4105CPC Aldo Keto reductase TL08_16575 ENOG4105CIR epoxide hydrolase TL08_16665 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein TL08_16670 ENOG4105EQ2 LysR family Transcriptional regulator TL08_16675 ENOG4108TVX serine protease TL08_16685 ENOG4105KVH Transcriptional regulator TL08_16705 ENOG4105CQB FAD linked oxidase domain protein TL08_16725 ENOG4108IG5 Transcriptional regulator TL08_16740 ENOG4105DE4 1-phosphofructokinase TL08_16745 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) TL08_16750 ENOG4107QNK )-transporter TL08_16755 ENOG4105E2D ec 3.2.1.52 TL08_16765 ENOG4108KDT Molybdate metabolism regulator TL08_16790 ENOG4108KDT Molybdate metabolism regulator TL08_16795 ENOG4108KDT Molybdate metabolism regulator TL08_16800 ENOG4105KKX ATPase associated with various cellular activities aaa_5 TL08_16805 ENOG4105RD5 TL08_16810 ENOG4105DEG Vwa containing coxe family protein TL08_16815 ENOG410903U zinc ion binding TL08_16855 ENOG4107SCJ type I restriction enzyme EcoKI subunit R TL08_16865 ENOG4105CVR type I restriction-modification system TL08_16910 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) TL08_16915 ENOG4105KME endoribonuclease L-psp TL08_16920 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) TL08_16930 ENOG4107U2T alpha beta TL08_16935 ENOG4108IJ9 (ABC) transporter TL08_17005 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TL08_17030 ENOG4105XPP Protein of unknown function (DUF1275) TL08_17050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_17070 ENOG4107S9F NmrA family TL08_17075 ENOG4105D9P serine threonine protein kinase TL08_17100 ENOG4106A3M Cytochrome p-450 TL08_17135 ENOG4105TVJ transport system, permease TL08_17140 ENOG4105DQ5 transport system permease protein TL08_17150 ENOG4108478 ec 3.2.1.18 TL08_17215 ENOG41082YX Transcriptional regulator, arsr family TL08_17240 ENOG4105VEQ Cold shock protein TL08_17265 ENOG4108MRH transcriptional regulatory protein TL08_17270 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism TL08_17275 ENOG4107QJT sodium dicarboxylate symporter TL08_17280 ENOG4105DR5 peptidase TL08_17290 ENOG4105K6H D-cysteine desulfhydrase TL08_17310 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin TL08_17390 ENOG4105CPQ Dehydrogenase TL08_17395 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) TL08_17405 ENOG41080R8 Conserved Protein TL08_17415 ENOG41061TZ Short-chain dehydrogenase reductase Sdr TL08_17425 ENOG4107TTA Xylose isomerase domain protein TIM barrel TL08_17440 ENOG4105CNN ABC, transporter TL08_17520 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TL08_17525 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TL08_17625 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes TL08_17640 ENOG41064E2 Xylose isomerase-like TIM barrel TL08_17650 ENOG4105CYP glycoside hydrolase, family TL08_17665 ENOG4105DRS transport system, permease TL08_17680 ENOG4105ETE Transcriptional regulator (LacI family TL08_17690 ENOG4105DAA L-lactate TL08_17700 ENOG4105CHR reductase TL08_17705 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) TL08_17715 ENOG4105NRA 50s ribosomal protein l31 type b TL08_17720 ENOG4105KDC 50s ribosomal protein l28 TL08_17725 ENOG4105W0E 50S ribosomal protein L33 TL08_17730 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) TL08_17735 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) TL08_17740 ENOG4105CV8 reductase TL08_17750 ENOG4105BZF Glycosyl transferase (Group 1 TL08_17755 ENOG4108RZE Tetr family transcriptional regulator TL08_17780 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase TL08_17785 ENOG4105DR5 peptidase TL08_17810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TL08_17815 ENOG4105BZ4 penicillin-binding protein TL08_17825 ENOG4105CHH sulfate transporter TL08_17845 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) TL08_17855 ENOG4105C29 acyl-CoA thioesterase TL08_17870 ENOG4105IIU Aminopeptidase TL08_17885 ENOG4105CBC glutamate synthase TL08_17890 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) TL08_17895 ENOG4105EHG Permease protein TL08_17900 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) TL08_17910 ENOG4107S91 Sodium hydrogen exchanger TL08_17915 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) TL08_17945 ENOG4105C26 Dehydrogenase TL08_17960 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) TL08_17965 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) TL08_17990 ENOG4108ZGX Histidine kinase TL08_17995 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_18015 ENOG4108YZ4 nudix hydrolase TL08_18020 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) TL08_18040 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TL08_18055 ENOG4105DSU hydrolase TL08_18090 ENOG4108VX5 3-methyladenine DNA glycosylase TL08_18095 ENOG4105CH7 arginosuccinase TL08_18100 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) TL08_18105 ENOG4105DBV ornithine carbamoyltransferase TL08_18115 ENOG4105CAS nag kinase TL08_18120 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) TL08_18125 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase TL08_18150 ENOG4107QV8 Conserved hypothetical protein 698 TL08_18155 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) TL08_18160 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) TL08_18175 ENOG4108RWN rrna methyltransferase TL08_18180 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) TL08_18185 ENOG41084BS 50S ribosomal protein L35 TL08_18225 ENOG4107VMB Beta-lactamase domain protein TL08_18235 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TL08_18245 ENOG4108K8S endonuclease I TL08_18305 ENOG4105M6F mutator MutT protein TL08_18315 ENOG4105BZW Glycerate kinase TL08_18330 ENOG4105BZU Histidine kinase TL08_18355 ENOG4107EEY synthase TL08_18380 ENOG4105EMU Dehydrogenase TL08_18390 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone TL08_18430 ENOG4105ETE Transcriptional regulator (LacI family TL08_18435 ENOG4107QK4 glycoside hydrolase, family 3 domain protein TL08_18455 ENOG4105FQP Beta-lactamase TL08_18460 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_18465 ENOG4105BZU Histidine kinase TL08_18475 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) TL08_18480 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) TL08_18525 ENOG4105CTB Polyprenyl synthetase TL08_18545 ENOG4107258 Transcriptional regulator TL08_18555 ENOG4106A3M Cytochrome p-450 TL08_18680 ENOG4105KF0 sporulation and cell division protein, SsgA TL08_18720 ENOG4105C01 Dihydroxy-acid dehydratase TL08_18740 ENOG4105E7U AraC family transcriptional regulator TL08_18800 ENOG4105DQ4 alcohol dehydrogenase TL08_18845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TL08_18890 ENOG4105S6R Iron-hydroxamate transporter permease subunit TL08_18900 ENOG4105E0A ABC, transporter TL08_18945 ENOG4107TPY serine threonine protein kinase TL08_18960 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_18965 ENOG4105ENE Histidine kinase TL08_18975 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TL08_18990 ENOG4105D5U fad dependent oxidoreductase TL08_19025 ENOG4105KKX ATPase associated with various cellular activities aaa_5 TL08_19030 ENOG4105DEG Vwa containing coxe family protein TL08_19065 ENOG410905P Pyridoxamine 5-phosphate TL08_19080 ENOG4105DSE periplasmic solute binding protein TL08_19090 ENOG4105CC5 ABC transporter TL08_19120 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TL08_19165 ENOG4108M0I Transcriptional regulator TL08_19170 ENOG4105D4T Citrate transporter TL08_19270 ENOG4105F0K SARP family transcriptional regulator TL08_19275 ENOG4105CHR reductase TL08_19290 ENOG410849S phosphocarrier protein (HPr) TL08_19295 ENOG4105DM4 PTS System TL08_19305 ENOG4105DE4 1-phosphofructokinase TL08_19310 ENOG4105E98 transcriptional regulator DeoR family TL08_19315 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) TL08_19320 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) TL08_19325 ENOG4107EXU Short-chain dehydrogenase reductase Sdr TL08_19355 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TL08_19380 ENOG4105DRS transport system, permease TL08_19405 ENOG41082A2 Alpha beta hydrolase TL08_19415 ENOG4108PSK reductase TL08_19425 ENOG4106A3M Cytochrome p-450 TL08_19440 ENOG4105FF5 Membrane TL08_19445 ENOG4105UNS Pfam:DUF419 TL08_19450 ENOG4105HDK L-asparaginase TL08_19465 ENOG4105DEF Extracellular solute-binding protein, family 5 TL08_19475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_19495 ENOG41069M3 Transcriptional regulator TL08_19505 ENOG4105F6U Short-chain dehydrogenase reductase Sdr TL08_19515 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) TL08_19525 ENOG4105CYX Short-chain dehydrogenase reductase Sdr TL08_19545 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) TL08_19570 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase TL08_19575 ENOG4105DKP glycosyl transferase, family 9 TL08_19580 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) TL08_19585 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) TL08_19600 ENOG4105C6Y Udp-glucose 6-dehydrogenase TL08_19610 ENOG4105C0B DNA polymerase III (alpha subunit) TL08_19630 ENOG4105EJ2 Transcriptional regulator TL08_19645 ENOG4107STQ Multicopper oxidase TL08_19650 ENOG4105C5I Dehydrogenase TL08_19660 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase TL08_19665 ENOG4106NZI LysR family Transcriptional regulator TL08_19670 ENOG4108J59 Extracellular solute-binding protein, family 5 TL08_19680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TL08_19685 ENOG4105C3U ABC transporter TL08_19690 ENOG4108JQ7 (ABC) transporter TL08_19705 ENOG4105MHT Transcriptional regulator, ARSR family TL08_19725 ENOG4107TCW O-succinylbenzoate synthase TL08_19730 ENOG4105C5I Dehydrogenase TL08_19735 ENOG4105EQX glucarate dehydratase TL08_19740 ENOG4107258 Transcriptional regulator TL08_19760 ENOG4105DUM transcriptional regulator, lysR family TL08_19765 ENOG4105EQ0 Major Facilitator superfamily TL08_19775 ENOG4105CPC Aldo Keto reductase TL08_19835 ENOG4105N14 lysine exporter protein LysE YggA TL08_19850 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) TL08_19855 ENOG4107QNK )-transporter TL08_19875 ENOG4105C57 major facilitator superfamily TL08_19880 ENOG4105C57 major facilitator superfamily TL08_19910 ENOG4105DKT Transcriptional regulator TL08_19915 ENOG4105CPQ Dehydrogenase TL08_19935 ENOG41082JN Transcriptional regulator TL08_19955 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) TL08_19975 ENOG4107SET aldo keto reductase TL08_19980 ENOG4105ES5 Histidine kinase TL08_19985 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TL08_20000 ENOG4106A3M Cytochrome p-450 TL08_20005 ENOG4106A3M Cytochrome p-450 TL08_20010 ENOG4108RNG Permease of the drug metabolite transporter TL08_20045 ENOG4108Y7V CRISPR-associated protein, Cse3 family TL08_20055 ENOG41060M0 Crispr-associated protein, cse4 family TL08_20090 ENOG4105CX8 fg-gap repeat protein TL08_20095 ENOG4108IG5 Transcriptional regulator TL08_20135 ENOG41060M0 Crispr-associated protein, cse4 family TL08_20140 ENOG4108VWQ crispr-associated protein TL08_20170 ENOG4105DWV Homoserine O-trans-acetylase TL08_20180 ENOG4105BZM domain protein TL08_20195 ENOG4105BZU Histidine kinase TL08_20200 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_20205 ENOG4105C4M (Ubiquinol oxidase) subunit I TL08_20215 ENOG4108JJ9 ABC, transporter TL08_20220 ENOG4105BZ1 (ABC) transporter TL08_20255 ENOG4105E0A ABC, transporter TL08_20260 ENOG4105EHG Permease protein TL08_20305 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) TL08_20310 ENOG4105WN5 stage II sporulation protein TL08_20345 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) TL08_20355 ENOG4107R7Y intracellular protease Pfpi family TL08_20390 ENOG4107R33 ppx gppa phosphatase TL08_20395 ENOG4108IJ9 (ABC) transporter TL08_20400 ENOG4105ETE Transcriptional regulator (LacI family TL08_20415 ENOG41060NJ transcriptional regulator TL08_20445 ENOG4108TCJ secreted hydrolase TL08_20450 ENOG4105C8Y Acetylornithine aminotransferase TL08_20460 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) TL08_20465 ENOG4105VBF alkaline shock protein TL08_20505 ENOG4105CUT histidyl-tRNA synthetase TL08_20515 ENOG4105KJM monovalent cation h antiporter subunit g TL08_20525 ENOG4105SC1 monovalent cation H antiporter subunit E TL08_20530 ENOG4108JPZ Monovalent cation H antiporter subunit D TL08_20535 ENOG4108ZE9 Monovalent cation H antiporter subunit C TL08_20540 ENOG4105D65 subunit l TL08_20560 ENOG4105E0X reductase TL08_20570 ENOG4107JTW chlorite dismutase TL08_20575 ENOG4105C1Q protoporphyrinogen oxidase TL08_20580 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) TL08_20590 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_20620 ENOG4105CHU acetyl-coa acetyltransferase TL08_20625 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase TL08_20640 ENOG4105DIA mandelate racemase muconate lactonizing TL08_20645 ENOG4105CMR udp-glucose 4-epimerase TL08_20655 ENOG410769Z extracellular solute-binding protein family 1 TL08_20660 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component TL08_20665 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component TL08_20690 ENOG4108J20 pectate lyase TL08_20695 ENOG4108J20 pectate lyase TL08_20700 ENOG4105DSG hydrolase family 43 TL08_20725 ENOG4105DET Rhamnulokinase TL08_20740 ENOG4105C9F isomerase TL08_20745 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) TL08_20750 ENOG4105ETE Transcriptional regulator (LacI family TL08_20775 ENOG4105C4C beta-galactosidase TL08_20780 ENOG4105DDC Oxidoreductase domain protein TL08_20795 ENOG4108E16 pectate lyase TL08_20815 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) TL08_20830 ENOG410870F Cyclic nucleotide-binding protein TL08_20850 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein TL08_20910 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_21010 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) TL08_21045 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) TL08_21060 ENOG4105BZU Histidine kinase TL08_21120 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_21125 ENOG4105BZU Histidine kinase TL08_21175 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_21180 ENOG4105BZU Histidine kinase TL08_21190 ENOG4105CJ1 ABC, transporter TL08_21200 ENOG4105CIR epoxide hydrolase TL08_21210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TL08_21225 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) TL08_21235 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) TL08_21240 ENOG4108KPJ rna polymerase sigma factor TL08_21250 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein TL08_21260 ENOG4105EC3 peptidase S51, dipeptidase E TL08_21265 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) TL08_21300 ENOG4108PJD permease TL08_21310 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) TL08_21335 ENOG4105CZV ABC transporter TL08_21340 ENOG4105FDP GntR family transcriptional regulator TL08_21345 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) TL08_21360 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) TL08_21380 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) TL08_21390 ENOG4107YU2 histidine triad (hIT) protein TL08_21400 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TL08_21405 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) TL08_21425 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) TL08_21445 ENOG4108IY8 ABC, transporter TL08_21450 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component TL08_21460 ENOG4108IPT Naphthoate synthase TL08_21480 ENOG4105CB2 alcohol dehydrogenase TL08_21490 ENOG4107QWG 2-Nitropropane dioxygenase TL08_21510 ENOG4105CFG Acts as a chaperone (By similarity) TL08_21515 ENOG4107QRT dEAD DEAH box helicase TL08_21560 ENOG41090CE integral membrane protein TL08_21565 ENOG4105KYH transcriptional regulatory protein TL08_21580 ENOG4105DZ6 Band 7 protein TL08_21600 ENOG4107VXM glycerophosphoryl diester phosphodiesterase TL08_21605 ENOG4105CHR reductase TL08_21610 ENOG4107RSM transcriptional regulator TL08_21625 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase TL08_21630 ENOG4105CNA YD repeat protein TL08_21640 ENOG4105CNA YD repeat protein TL08_21665 ENOG4105E9Q Acyl-transferase TL08_21680 ENOG4105DKQ ROK family TL08_21690 ENOG4105D0U Arsenite-activated ATPase (ArsA) TL08_21715 ENOG4105JNK Glycosyl transferase (Group 1 TL08_21755 ENOG4107UDY cytochrome C TL08_21760 ENOG4105CCU oxidase (Subunit III) TL08_21775 ENOG4107S1N anthranilate phosphoribosyltransferase TL08_21780 ENOG4108ZRS Part of cytochrome c oxidase, its function is TL08_21785 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) TL08_21815 ENOG4105CPC Aldo Keto reductase TL08_21825 ENOG4108YZT Adenosylcobinamide kinase TL08_21830 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) TL08_21835 ENOG41080Z7 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) TL08_21840 ENOG4105CM2 brancheD-chain amino acid aminotransferase TL08_21855 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TL08_21880 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) TL08_21890 ENOG41061TZ Short-chain dehydrogenase reductase Sdr TL08_21895 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) TL08_21915 ENOG4105C5F glutamine synthetase TL08_21925 ENOG4105KVH Transcriptional regulator TL08_21945 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) TL08_21980 ENOG4105C5F glutamine synthetase TL08_21990 ENOG4105C4K Nad synthetase TL08_22000 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) TL08_22005 ENOG4105CHF Glutathione S-transferase TL08_22080 ENOG4105CVJ phosphoglycerate mutase TL08_22135 ENOG4105MC2 DSBA oxidoreductase TL08_22155 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) TL08_22175 ENOG4105CJW magnesium transporter TL08_22210 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TL08_22215 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TL08_22245 ENOG4107QN2 dihydrolipoyl dehydrogenase TL08_22290 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) TL08_22330 ENOG4108375 Acylphosphatase (EC 3.6.1.7) TL08_22335 ENOG4105K4I Scp-like extracellular TL08_22355 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) TL08_22365 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) TL08_22380 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) TL08_22385 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) TL08_22390 ENOG41084BZ 50S ribosomal protein L32 TL08_22410 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) TL08_22415 ENOG4106H78 methyltransferase TL08_22425 ENOG4108ZT1 Transcriptional regulator TL08_22430 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) TL08_22480 ENOG4105RHY Pfam:UPF0157 TL08_22490 ENOG4105DUU IucA IucC family protein TL08_22500 ENOG4107EFR Flavocytochrome c TL08_22520 ENOG4105CB5 ATP-dependent DNA helicase recG TL08_22525 ENOG4105DP4 dak2 domain fusion protein ylov TL08_22530 ENOG4105VB9 50S ribosomal protein l28 TL08_22535 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) TL08_22545 ENOG4108Z0R Transferase TL08_22570 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TL08_22575 ENOG4105DVE abc transporter atp-binding protein TL08_22590 ENOG4105CPF Cell wall formation (By similarity) TL08_22595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TL08_22610 ENOG4105C28 cystathionine TL08_22615 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase TL08_22625 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) TL08_22645 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TL08_22650 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) TL08_22670 ENOG4105PAD Hydrolase TL08_22675 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) TL08_22685 ENOG4105ERH Fumarylacetoacetate hydrolase TL08_22690 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) TL08_22700 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TL08_22705 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin TL08_22725 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase TL08_22730 ENOG4108ZP8 Acetolactate synthase small subunit TL08_22745 ENOG4105C01 Dihydroxy-acid dehydratase TL08_22765 ENOG4108762 serine threonine protein kinase TL08_22785 ENOG4108VGI doxx family TL08_22805 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TL08_22820 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) TL08_22825 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TL08_22830 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TL08_22850 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) TL08_22870 ENOG4105C7B Threonine dehydratase TL08_22875 ENOG4105FDF Could be involved in DNA repair (By similarity) TL08_22895 ENOG4107TTQ Alpha beta hydrolase fold TL08_22915 ENOG4105C1G acyl-Coa dehydrogenase TL08_22925 ENOG4107QX3 carboxylase TL08_22965 ENOG4105VG5 Membrane TL08_22975 ENOG4108K8K Transcriptional regulator TL08_22980 ENOG4105DCF alanine dehydrogenase TL08_23005 ENOG4105BZ1 (ABC) transporter TL08_23010 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 TL08_23040 ENOG4105CI2 imidazolone-5-propionate hydrolase TL08_23075 ENOG4105CGP Urocanate hydratase TL08_23080 ENOG4105C84 Histidine ammonia-lyase TL08_23105 ENOG4105E90 ABC transporter TL08_23110 ENOG4105E90 ABC transporter TL08_23115 ENOG4108IJ8 ABC transporter TL08_23120 ENOG4108JVH Protein of unknown function DUF43 TL08_23130 ENOG4105BZU Histidine kinase TL08_23145 ENOG4108ZM9 phosphoglycerate mutase TL08_23165 ENOG4105CBD Diacylglycerol kinase TL08_23180 ENOG4105WMN AntiSigma factor TL08_23190 ENOG4108Z66 YbaK ebsC protein TL08_23200 ENOG4108RAV Conserved protein TL08_23205 ENOG4108RAV Conserved protein TL08_23210 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase TL08_23215 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) TL08_23230 ENOG4105C26 Dehydrogenase TL08_23245 ENOG4105C2N RNA methyltransferase TrmH family group 3 TL08_23260 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TL08_23265 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea TL08_23290 ENOG4105BZU Histidine kinase TL08_23295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TL08_23310 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) TL08_23335 ENOG4105CUB amino acid TL08_23340 ENOG4105EIP mannose-6-phosphate isomerase TL08_23350 ENOG4105W49 UPF0434 protein TL08_23370 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) TL08_23380 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase TL08_23385 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) TL08_23425 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) TL08_23440 ENOG4107TB5 TRANSCRIPTIONal TL08_23445 ENOG4107TB5 TRANSCRIPTIONal TL08_23470 ENOG4105CJ1 ABC, transporter TL08_23495 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane TL08_23500 ENOG4105C2J ABC transporter TL08_23505 ENOG4105CB5 ATP-dependent DNA helicase recG TL08_23515 ENOG4105E0Y RtcB Protein TL08_23520 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) TL08_23550 ENOG4108S0S Nucleotidyl transferase TL08_23555 ENOG41065SU Two-component system sensor kinase TL08_23560 ENOG4105ETX regulatoR TL08_23565 ENOG4107TK4 histidinol-phosphate phosphatase TL08_23595 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase TL08_23620 ENOG4105D8K carboxyl transferase TL08_23645 ENOG4105DR5 peptidase TL08_23705 ENOG4105C4Y ABC transporter TL08_23715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TL08_23720 ENOG4105C7F AcnD-accessory protein PrpF TL08_23725 ENOG41080UQ Transcriptional regulator TL08_23730 ENOG4107WR6 Maf-like protein TL08_23740 ENOG4108ETY sodium dicarboxylate symporter TL08_23745 ENOG4108JIK carboxylase TL08_23785 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TL08_23790 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) TL08_23795 ENOG4105C6V Glycerol-3-phosphate dehydrogenase TL08_23820 ENOG4107RM1 amidohydrolase TL08_23855 ENOG4105F8V Hydrolase, tatD family TL08_23870 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) TL08_23895 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TL08_23900 ENOG4105CNN ABC, transporter TL08_23905 ENOG4105C2J ABC transporter TL08_23915 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) TL08_23935 ENOG4105GFG DUF218 domain TL08_23945 ENOG4105BZU Histidine kinase TL08_23950 ENOG4108M15 ABC transporter TL08_23960 ENOG4105E2R ROK family TL08_23985 ENOG4105KJM monovalent cation h antiporter subunit g TL08_24000 ENOG4108JPZ Monovalent cation H antiporter subunit D TL08_24005 ENOG4105MKQ Monovalent cation H antiporter subunit C TL08_24015 ENOG4105D65 subunit l TL08_24020 ENOG4105D5P Methylmalonyl-coA mutase TL08_24025 ENOG4107TPY serine threonine protein kinase TL08_24035 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain TL08_24040 ENOG4108FN7 Aldo keto reductase TL08_24060 ENOG4107QX3 carboxylase TL08_24070 ENOG4105BZU Histidine kinase TL08_24075 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_24085 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TL08_24090 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TL08_24105 ENOG4105CHR reductase TL08_24125 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) TL08_24145 ENOG410900P UPF0336 protein TL08_24160 ENOG4107R13 MMPL domain protein TL08_24180 ENOG4107R13 MMPL domain protein TL08_24185 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) TL08_24250 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family TL08_24255 ENOG4105D5G Transposase TL08_24260 ENOG4108R86 Transcriptional regulator TL08_24295 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) TL08_24300 ENOG4105C26 Dehydrogenase TL08_24305 ENOG4105C26 Dehydrogenase TL08_24335 ENOG4105DA5 (ABC) transporter TL08_24360 ENOG4108M15 ABC transporter TL08_24385 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) TL08_24415 ENOG4108JQ9 ABC transporter TL08_24420 ENOG4105DIH basic membrane TL08_24445 ENOG4105DZ1 carboxypeptidase TL08_24450 ENOG4107H3J ribonuclease TL08_24465 ENOG4105CGK Exodeoxyribonuclease III TL08_24505 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) TL08_24520 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TL08_24550 ENOG4105C0B DNA polymerase III (alpha subunit) TL08_24595 ENOG4105CMV Succinyl-CoA synthetase subunit beta TL08_24610 ENOG4105DR5 peptidase TL08_24615 ENOG4105DR5 peptidase TL08_24655 ENOG4105DQR SNARE associated Golgi TL08_24670 ENOG4108TN2 lmbE family TL08_24735 ENOG4105ETE Transcriptional regulator (LacI family TL08_24740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TL08_24755 ENOG4108KTG Membrane protein, drug metabolite transporter TL08_24765 ENOG4107QVP Dehydrogenase TL08_24800 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) TL08_24805 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TL08_24810 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) TL08_24815 ENOG4105DGI Alkaline phosphatase TL08_24820 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TL08_24825 ENOG41080E2 ribosomal-protein-alanine acetyltransferase TL08_24835 ENOG4107R9S Malate synthase TL08_24845 ENOG4108097 ATP-binding protein TL08_24865 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TL08_24915 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) TL08_24920 ENOG4108UJD 30S ribosomal protein S9 TL08_24925 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) TL08_24950 ENOG4105EC2 ftsk spoIIIe TL08_24960 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin TL08_25020 ENOG4105BZU Histidine kinase TL08_25060 ENOG4105EC2 ftsk spoIIIe TL08_25070 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) TL08_25075 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein TL08_25080 ENOG4105CFF transcriptional regulator TL08_25090 ENOG4108IUX (ABC) transporter TL08_25095 ENOG4105RHA ABC transporter, permease TL08_25115 ENOG4105CI2 imidazolone-5-propionate hydrolase TL08_25120 ENOG4107WI4 Aldose-1-epimerase TL08_25125 ENOG4105DVH amino acid TL08_25130 ENOG4105E8G Major facilitator Superfamily TL08_25135 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) TL08_25140 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) TL08_25165 ENOG4105BZ1 (ABC) transporter TL08_25170 ENOG4105BZ1 (ABC) transporter TL08_25180 ENOG4105FCS tRNA rRNA methyltransferase TL08_25190 ENOG4107SFI Major Facilitator superfamily TL08_25200 ENOG4105C7N Xanthine uracil vitamin C permease TL08_25225 ENOG4108N0W Major Facilitator superfamily TL08_25235 ENOG4105VEQ Cold shock protein TL08_25250 ENOG4107TIF Phenazine biosynthesis protein, PhzF family TL08_25260 ENOG4105F4R Transcriptional regulator mode TL08_25265 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TL08_25275 ENOG4105MS9 Resuscitation-promoting factor TL08_25315 ENOG4105GWZ Roadblock lc7 family protein TL08_25340 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component TL08_25350 ENOG4105CFI type iii restriction protein res subunit TL08_25385 ENOG4106N3A copper homeostasis protein cutc TL08_25410 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TL08_25440 ENOG4107S5I aldo keto reductase TL08_25450 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) TL08_25495 ENOG4106BRA Membrane TL08_25520 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin TL08_25545 ENOG4105EEM helicase TL08_25565 ENOG4105KVH Transcriptional regulator TL08_25575 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TL08_25585 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TL08_25595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TL08_25600 ENOG4108VW9 Membrane TL08_25610 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase TL08_25615 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family TL08_25625 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) TL08_25655 ENOG4105K64 Glycosyl transferase, family 2 TL08_25665 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase TL08_25720 ENOG4108KGH TRANSCRIPTIONal TL08_25740 ENOG4105C1G acyl-Coa dehydrogenase TL08_25770 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) TL08_25825 ENOG4105JN3 extra-cytoplasmic solute receptor family protein TL08_25830 ENOG4107258 Transcriptional regulator TL08_25835 ENOG4105JSC dimethylmenaquinone methyltransferase TL08_25840 ENOG4108JQ1 Dehydrogenase TL08_25860 ENOG4105BZU Histidine kinase TL08_25875 ENOG4108UTW Plays a role in the regulation of phosphate uptake TL08_25885 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) TL08_25890 ENOG4105E2Z phosphate ABC transporter (Permease TL08_25905 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) TL08_25910 ENOG4107NHD transcriptional regulator TL08_25935 ENOG4105KHC sulfurtransferase TL08_25940 ENOG4105PKJ carbohydrate binding TL08_25945 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands TL08_25960 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) TL08_26010 ENOG4105CXB phosphoribosylaminoimidazole synthetase TL08_26025 ENOG4105BZP glycoside hydrolase 15-related TL08_26030 ENOG4105BZU Histidine kinase TL08_26045 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii TL08_26050 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I TL08_26055 ENOG410839H phosphoribosylformylglycinamidine synthase TL08_26060 ENOG4105C8V SAICAR synthetase TL08_26080 ENOG4105C83 adenylosuccinate lyase TL08_26090 ENOG4105NAF rna polymerase sigma factor TL08_26095 ENOG4107TXC Transcriptional regulator TL08_26110 ENOG4105KPY Small multidrug resistance protein TL08_26140 ENOG4105CHM Aminotransferase TL08_26160 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis TL08_26225 ENOG4105CE4 GlcNAc 6-P deacetylase TL08_26235 ENOG4105CQB FAD linked oxidase domain protein TL08_26245 ENOG4105WH1 Two component transcriptional regulator luxr family TL08_26270 ENOG4105CFG Acts as a chaperone (By similarity) TL08_26320 ENOG4105BZG amino acid carrier protein TL08_26325 ENOG4105C8P )-transporter TL08_26330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TL08_26355 ENOG4106JDR secreted TL08_26380 ENOG4108V0P LemA family TL08_26385 ENOG4105C2N RNA methyltransferase TrmH family group 3 TL08_26405 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) TL08_26415 ENOG4105KNI merR family transcriptional Regulator TL08_26420 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TL08_26425 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ TL08_26430 ENOG4105CFG Acts as a chaperone (By similarity) TL08_26440 ENOG4105DF6 Fe-S oxidoreductase TL08_26445 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) TL08_26450 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TL08_26470 ENOG4105DCF alanine dehydrogenase TL08_26490 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) TL08_26535 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) TL08_26540 ENOG4105EHG Permease protein TL08_26555 ENOG4105EWN Heme oxygenase TL08_26565 ENOG4108PSK reductase TL08_26575 ENOG4108Z6Z Transcriptional regulator TL08_26590 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) TL08_26600 ENOG4105DHP deoxycytidine triphosphate deaminase TL08_26605 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 TL08_26630 ENOG4106NZI LysR family Transcriptional regulator TL08_26635 ENOG4105E8R UPF0173 metal-dependent hydrolase TL08_26640 ENOG4105CSU acyl-Coa dehydrogenase TL08_26665 ENOG4108RZE Tetr family transcriptional regulator TL08_26675 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) TL08_26710 ENOG4105CFC Transporter TL08_26720 ENOG4105CDA abc transporter atp-binding protein TL08_26725 ENOG4105E5Q amino acid AbC transporter TL08_26730 ENOG4107R0W ABC transporter TL08_26740 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) TL08_26750 ENOG4105CPP Dehydrogenase, E1 component TL08_26755 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 TL08_26780 ENOG4105E1F short-chain dehydrogenase reductase TL08_26795 ENOG4105CZA synthase TL08_26815 ENOG4105BZ4 penicillin-binding protein TL08_26840 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) TL08_26845 ENOG4107YH6 single-stranded DNA-binding protein TL08_26850 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) TL08_26855 ENOG4105K9Q Binds to the 23S rRNA (By similarity) TL08_26900 ENOG4105C22 threonyL-tRNA synthetase TL08_26935 ENOG4105BZU Histidine kinase TL08_26955 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) TL08_26960 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) TL08_26965 ENOG4108RVA ribokinase TL08_26970 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TL08_26975 ENOG4105CNN ABC, transporter TL08_26980 ENOG4105C2J ABC transporter TL08_26985 ENOG4105ETE Transcriptional regulator (LacI family TL08_27005 ENOG4105C8T Leucyl-tRNA synthetase TL08_27035 ENOG41081DT UPF0301 protein TL08_27050 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate TL08_27070 ENOG4107QPV Serine Threonine protein kinase TL08_27085 ENOG4105C3M thioredoxin reductase TL08_27090 ENOG4105K63 Thioredoxin TL08_27095 ENOG4108E1C hydrolase TL08_27105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TL08_27110 ENOG4105CPF Cell wall formation (By similarity) TL08_27120 ENOG4107QJE Chromosome Partitioning Protein TL08_27125 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) TL08_27130 ENOG4105CS9 pantothenic acid kinase TL08_27145 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) TL08_27150 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) TL08_27155 ENOG41084CH 50S ribosomal protein l34