locus-tag	class	description
TL08_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TL08_00010	COG0592	DNA-directed DNA polymerase activity
TL08_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TL08_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TL08_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TL08_00030	COG0187	DNA topoisomerase II activity
TL08_00095	COG3764	Sortase (surface protein transpeptidase)
TL08_00120	COG0515	serine threonine protein kinase
TL08_00120	COG2815	serine threonine protein kinase
TL08_00125	COG0515	serine threonine protein kinase
TL08_00130	COG0768	penicillin binding
TL08_00145	COG1716	ATPase activity
TL08_00155	COG1716	ATPase activity
TL08_00170	COG0018	arginyl-trna synthetase
TL08_00195	COG1309	transcriptional regulator
TL08_00250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TL08_00265	COG1174	glycine betaine transport
TL08_00290	COG0667	Aldo Keto reductase
TL08_00315	COG0438	transferase activity, transferring glycosyl groups
TL08_00330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TL08_00340	COG1404	Belongs to the peptidase S8 family
TL08_00355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TL08_00365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TL08_00365	COG0425	Belongs to the sulfur carrier protein TusA family
TL08_00375	COG1595	DNA-templated transcription, initiation
TL08_00380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TL08_00390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TL08_00400	COG3279	Response regulator of the LytR AlgR family
TL08_00410	COG3275	phosphorelay sensor kinase activity
TL08_00430	COG0653	protein targeting
TL08_00490	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_00495	COG1309	transcriptional regulator
TL08_00500	COG1528	Iron-storage protein
TL08_00505	COG2235	arginine
TL08_00560	COG1271	oxidase subunit
TL08_00565	COG1294	oxidase, subunit
TL08_00570	COG4988	ABC transporter
TL08_00600	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TL08_00630	COG0754	glutathionylspermidine amidase activity
TL08_00635	COG3766	membrane
TL08_00645	COG1396	sequence-specific DNA binding
TL08_00660	COG0561	phosphatase activity
TL08_00665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TL08_00705	COG1216	Glycosyl transferase, family 2
TL08_00710	COG1216	Glycosyl transferase, family 2
TL08_00745	COG2234	aminopeptidase activity
TL08_00755	COG1846	Transcriptional regulator
TL08_00775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TL08_00780	COG0412	Dienelactone hydrolase
TL08_00785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TL08_00815	COG0183	Belongs to the thiolase family
TL08_00825	COG0287	Prephenate dehydrogenase
TL08_00845	COG1595	DNA-templated transcription, initiation
TL08_00860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TL08_00880	COG1309	transcriptional regulator
TL08_00890	COG1349	DNA-binding transcription factor activity
TL08_00895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TL08_00905	COG0601	transmembrane transport
TL08_00910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_00915	COG0444	Belongs to the ABC transporter superfamily
TL08_00920	COG4608	Belongs to the ABC transporter superfamily
TL08_00925	COG0667	Aldo Keto reductase
TL08_00940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TL08_00945	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_00950	COG1914	H( )-stimulated, divalent metal cation uptake system
TL08_01040	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_01070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TL08_01075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TL08_01085	COG0747	negative chemotaxis
TL08_01100	COG0444	Belongs to the ABC transporter superfamily
TL08_01105	COG4608	Belongs to the ABC transporter superfamily
TL08_01165	COG1764	response to oxidative stress
TL08_01195	COG1408	metallophosphoesterase
TL08_01205	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
TL08_01210	COG4499	WXG100 protein secretion system (Wss), protein YukC
TL08_01210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL08_01220	COG0003	Pfam Anion-transporting ATPase
TL08_01255	COG0673	inositol 2-dehydrogenase activity
TL08_01270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TL08_01315	COG0596	Alpha beta hydrolase
TL08_01325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TL08_01330	COG0730	response to heat
TL08_01360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TL08_01395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TL08_01400	COG1737	Transcriptional regulator
TL08_01425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL08_01430	COG3876	Protein conserved in bacteria
TL08_01435	COG1472	Belongs to the glycosyl hydrolase 3 family
TL08_01490	COG1205	dead DEAH box helicase
TL08_01490	COG1111	helicase
TL08_01495	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TL08_01505	COG1754	DNA topoisomerase type I activity
TL08_01505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TL08_01515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TL08_01520	COG0470	DNA polymerase III
TL08_01530	COG0582	viral genome integration into host DNA
TL08_01570	COG2816	NAD+ diphosphatase activity
TL08_01620	COG2267	carboxylic ester hydrolase activity
TL08_01640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TL08_01655	COG0037	tRNA processing
TL08_01665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TL08_01670	COG0302	gtp cyclohydrolase
TL08_01675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TL08_01715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TL08_01720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TL08_01725	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TL08_01730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TL08_01745	COG0542	response to heat
TL08_01755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TL08_01780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TL08_01790	COG1329	Transcriptional regulator
TL08_01795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TL08_01800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TL08_01865	COG0215	cysteine-tRNA ligase activity
TL08_01880	COG2226	methyltransferase
TL08_01895	COG2311	Membrane
TL08_01910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_01915	COG1121	(ABC) transporter
TL08_01920	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL08_01935	COG3842	ATPase activity
TL08_01940	COG3833	ABC-type maltose transport systems, permease component
TL08_01945	COG1175	transmembrane transport
TL08_01960	COG1609	Transcriptional regulator
TL08_01970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TL08_01985	COG0667	Aldo Keto reductase
TL08_01990	COG0456	acetyltransferase
TL08_01995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TL08_02000	COG1917	Cupin 2, conserved barrel domain protein
TL08_02005	COG5285	phytanoyl-CoA dioxygenase
TL08_02015	COG3629	intracellular signal transduction
TL08_02015	COG3903	Transcriptional regulator
TL08_02030	COG2186	Transcriptional regulator
TL08_02045	COG0242	peptide deformylase activity
TL08_02050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TL08_02055	COG0351	phosphomethylpyrimidine kinase
TL08_02075	COG2022	thiamine diphosphate biosynthetic process
TL08_02085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TL08_02085	COG2022	thiamine diphosphate biosynthetic process
TL08_02125	COG2188	Transcriptional regulator
TL08_02145	COG1472	Belongs to the glycosyl hydrolase 3 family
TL08_02150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TL08_02165	COG2197	response regulator
TL08_02180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TL08_02205	COG0788	formyltetrahydrofolate deformylase activity
TL08_02210	COG1309	transcriptional regulator
TL08_02230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TL08_02235	COG4133	protoheme IX ABC transporter activity
TL08_02275	COG0477	Major facilitator Superfamily
TL08_02280	COG0438	transferase activity, transferring glycosyl groups
TL08_02290	COG0588	phosphoglycerate mutase activity
TL08_02295	COG5002	protein histidine kinase activity
TL08_02315	COG0506	proline dehydrogenase activity
TL08_02340	COG0560	Phosphoserine phosphatase
TL08_02350	COG1960	acyl-CoA dehydrogenase activity
TL08_02375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TL08_02380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TL08_02395	COG0113	porphobilinogen synthase activity
TL08_02425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TL08_02430	COG0406	alpha-ribazole phosphatase activity
TL08_02435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TL08_02450	COG0785	Cytochrome C biogenesis protein
TL08_02460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TL08_02480	COG1522	sequence-specific DNA binding
TL08_02490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TL08_02515	COG1575	Belongs to the MenA family. Type 1 subfamily
TL08_02525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TL08_02530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TL08_02545	COG1169	isochorismate synthase
TL08_02560	COG3396	Phenylacetate-CoA oxygenase
TL08_02565	COG3460	Phenylacetate-CoA oxygenase
TL08_02570	COG3396	Phenylacetate-CoA oxygenase
TL08_02575	COG2151	metal-sulfur cluster biosynthetic enzyme
TL08_02580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TL08_02595	COG2226	methyltransferase
TL08_02610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TL08_02615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TL08_02620	COG0649	NAD binding
TL08_02630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TL08_02635	COG1034	ATP synthesis coupled electron transport
TL08_02640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TL08_02645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TL08_02650	COG0839	Belongs to the complex I subunit 6 family
TL08_02655	COG0713	ATP synthesis coupled electron transport
TL08_02670	COG1007	ATP synthesis coupled electron transport
TL08_02690	COG1013	pyruvate-flavodoxin oxidoreductase activity
TL08_02695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TL08_02695	COG0674	pyruvate-flavodoxin oxidoreductase activity
TL08_02700	COG1522	sequence-specific DNA binding
TL08_02705	COG1834	amidinotransferase
TL08_02710	COG2205	protein histidine kinase activity
TL08_02715	COG0745	RESPONSE REGULATOR receiver
TL08_02730	COG1136	(ABC) transporter
TL08_02730	COG0577	efflux transmembrane transporter activity
TL08_02735	COG1136	(ABC) transporter
TL08_02735	COG0577	efflux transmembrane transporter activity
TL08_02750	COG0515	serine threonine protein kinase
TL08_02750	COG2815	serine threonine protein kinase
TL08_02780	COG0596	Alpha beta hydrolase
TL08_02790	COG0501	Belongs to the peptidase M48B family
TL08_02800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TL08_02830	COG1666	GTP binding
TL08_02850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TL08_02855	COG2030	dehydratase
TL08_02865	COG0436	Aminotransferase
TL08_02885	COG0081	regulation of translation
TL08_02895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TL08_02905	COG0085	RNA polymerase activity
TL08_02910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TL08_02930	COG1131	(ABC) transporter
TL08_02940	COG2197	response regulator
TL08_02955	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TL08_02960	COG0049	tRNA binding
TL08_02965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TL08_02975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TL08_02980	COG0051	transcription antitermination factor activity, RNA binding
TL08_02985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TL08_02990	COG0088	Forms part of the polypeptide exit tunnel
TL08_02995	COG0089	rRNA binding
TL08_03000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TL08_03005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TL08_03010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TL08_03015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TL08_03020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TL08_03025	COG0255	Belongs to the universal ribosomal protein uL29 family
TL08_03030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TL08_03035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TL08_03040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TL08_03045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TL08_03050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TL08_03055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TL08_03060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TL08_03070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TL08_03075	COG1841	ribosomal large subunit assembly
TL08_03080	COG0200	Binds to the 23S rRNA
TL08_03095	COG0563	adenylate kinase activity
TL08_03120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TL08_03125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TL08_03130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TL08_03135	COG0202	RNA polymerase activity
TL08_03140	COG0203	ribosomal protein L17
TL08_03145	COG0101	tRNA pseudouridine synthase activity
TL08_03155	COG2197	response regulator
TL08_03165	COG3903	Transcriptional regulator
TL08_03165	COG3629	intracellular signal transduction
TL08_03200	COG3706	GGDEF domain
TL08_03200	COG0745	RESPONSE REGULATOR receiver
TL08_03210	COG2860	membrane
TL08_03215	COG0745	RESPONSE REGULATOR receiver
TL08_03220	COG2205	protein histidine kinase activity
TL08_03230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TL08_03235	COG0521	Mo-molybdopterin cofactor biosynthetic process
TL08_03235	COG0315	cyclic pyranopterin monophosphate synthase activity
TL08_03250	COG1970	mechanosensitive ion channel activity
TL08_03265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TL08_03270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TL08_03280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TL08_03370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL08_03375	COG0574	Belongs to the PEP-utilizing enzyme family
TL08_03375	COG3848	Pyruvate phosphate dikinase
TL08_03385	COG2205	protein histidine kinase activity
TL08_03390	COG0745	RESPONSE REGULATOR receiver
TL08_03425	COG0640	Transcriptional regulator
TL08_03435	COG4989	oxidoreductase activity
TL08_03460	COG0714	Associated with various cellular activities
TL08_03485	COG3850	Histidine kinase
TL08_03490	COG2197	response regulator
TL08_03530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL08_03535	COG0084	hydrolase, TatD family'
TL08_03540	COG1652	LysM domain
TL08_03565	COG1309	transcriptional regulator
TL08_03615	COG1595	DNA-templated transcription, initiation
TL08_03625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TL08_03630	COG2011	ABC-type metal ion transport system permease component
TL08_03635	COG1464	Belongs to the NlpA lipoprotein family
TL08_03640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TL08_03655	COG0488	(ABC) transporter
TL08_03680	COG0193	aminoacyl-tRNA hydrolase activity
TL08_03685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TL08_03700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TL08_03705	COG0745	RESPONSE REGULATOR receiver
TL08_03705	COG3706	GGDEF domain
TL08_03720	COG1309	transcriptional regulator
TL08_03745	COG0793	Belongs to the peptidase S41A family
TL08_03745	COG4946	Tricorn protease homolog
TL08_03770	COG0148	phosphopyruvate hydratase activity
TL08_03820	COG1252	NADH dehydrogenase
TL08_03860	COG0183	Belongs to the thiolase family
TL08_03885	COG1414	Transcriptional regulator
TL08_03900	COG2182	Extracellular solute-binding protein
TL08_03910	COG0395	ABC-type sugar transport system, permease component
TL08_03925	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_03980	COG2130	NADP-dependent
TL08_03995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_04000	COG3386	PFAM SMP-30 Gluconolaconase
TL08_04010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TL08_04025	COG3708	Transcriptional regulator
TL08_04025	COG2207	Transcriptional regulator
TL08_04030	COG3185	4-Hydroxyphenylpyruvate dioxygenase
TL08_04045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TL08_04070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TL08_04085	COG3866	Pectate lyase
TL08_04100	COG1331	Highly conserved protein containing a thioredoxin domain
TL08_04125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TL08_04135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_04145	COG0584	glycerophosphoryl diester phosphodiesterase
TL08_04150	COG0114	fumarate hydratase activity
TL08_04155	COG0492	ferredoxin-NADP+ reductase activity
TL08_04190	COG1722	exodeoxyribonuclease VII activity
TL08_04200	COG1570	exodeoxyribonuclease VII activity
TL08_04210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TL08_04225	COG0420	3'-5' exonuclease activity
TL08_04230	COG0419	ATPase involved in DNA repair
TL08_04240	COG0012	GTP binding
TL08_04265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TL08_04275	COG1309	transcriptional regulator
TL08_04280	COG0778	Nitroreductase
TL08_04350	COG4585	Histidine kinase
TL08_04370	COG2154	pterin-4-alpha-carbinolamine dehydratase
TL08_04380	COG4149	molybdate abc transporter
TL08_04385	COG3842	ATPase activity
TL08_04395	COG1131	(ABC) transporter
TL08_04405	COG0745	RESPONSE REGULATOR receiver
TL08_04425	COG0747	negative chemotaxis
TL08_04430	COG0747	negative chemotaxis
TL08_04440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_04450	COG4608	Belongs to the ABC transporter superfamily
TL08_04455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TL08_04475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TL08_04490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TL08_04510	COG0655	NAD(P)H dehydrogenase (quinone) activity
TL08_04515	COG1611	Belongs to the LOG family
TL08_04520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TL08_04600	COG1024	Enoyl-CoA hydratase
TL08_04615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TL08_04620	COG0583	DNA-binding transcription factor activity
TL08_04625	COG2814	Major facilitator Superfamily
TL08_04630	COG0297	glycogen (starch) synthase activity
TL08_04635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TL08_04640	COG4122	O-methyltransferase activity
TL08_04645	COG1595	DNA-templated transcription, initiation
TL08_04660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TL08_04715	COG0598	Magnesium transport protein CorA
TL08_04735	COG0613	PHP domain protein
TL08_04760	COG0513	Belongs to the DEAD box helicase family
TL08_04810	COG1587	Uroporphyrinogen-III synthase
TL08_04820	COG0210	DNA helicase
TL08_04825	COG0210	DNA helicase
TL08_04840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TL08_04865	COG0612	Peptidase, M16
TL08_04900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TL08_04925	COG3480	Lon protease (S16) C-terminal proteolytic domain
TL08_04935	COG1615	UPF0182 protein
TL08_04955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TL08_04960	COG2884	Cell division ATP-binding protein ftsE
TL08_04965	COG2177	Part of the ABC transporter FtsEX involved in
TL08_04970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TL08_04985	COG0778	Nitroreductase
TL08_05025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_05100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TL08_05120	COG0640	Transcriptional regulator
TL08_05125	COG0586	Pfam SNARE associated Golgi protein
TL08_05130	COG2197	response regulator
TL08_05135	COG4585	Histidine kinase
TL08_05145	COG0737	Belongs to the 5'-nucleotidase family
TL08_05150	COG1643	Atp-dependent helicase
TL08_05155	COG2814	Major facilitator Superfamily
TL08_05170	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_05180	COG3903	Transcriptional regulator
TL08_05180	COG3629	intracellular signal transduction
TL08_05195	COG2814	Major facilitator Superfamily
TL08_05205	COG3629	intracellular signal transduction
TL08_05205	COG3903	Transcriptional regulator
TL08_05220	COG2197	response regulator
TL08_05240	COG1335	isochorismatase
TL08_05245	COG0583	DNA-binding transcription factor activity
TL08_05265	COG1253	flavin adenine dinucleotide binding
TL08_05270	COG1253	flavin adenine dinucleotide binding
TL08_05275	COG4221	oxidoreductase activity
TL08_05320	COG1131	(ABC) transporter
TL08_05350	COG0667	Aldo Keto reductase
TL08_05360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TL08_05365	COG4221	oxidoreductase activity
TL08_05390	COG0583	DNA-binding transcription factor activity
TL08_05400	COG2130	NADP-dependent
TL08_05420	COG0477	Major facilitator Superfamily
TL08_05430	COG1064	alcohol dehydrogenase
TL08_05440	COG1063	alcohol dehydrogenase
TL08_05465	COG1012	belongs to the aldehyde dehydrogenase family
TL08_05495	COG1131	(ABC) transporter
TL08_05510	COG2197	response regulator
TL08_05530	COG0745	RESPONSE REGULATOR receiver
TL08_05535	COG2205	protein histidine kinase activity
TL08_05545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TL08_05545	COG2755	lipolytic protein G-D-S-L family
TL08_05550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TL08_05555	COG0583	DNA-binding transcription factor activity
TL08_05575	COG0583	DNA-binding transcription factor activity
TL08_05585	COG4941	Belongs to the sigma-70 factor family
TL08_05600	COG1122	ATPase activity
TL08_05645	COG1819	glycosyl
TL08_05655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TL08_05675	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_05680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_05690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TL08_05695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_05700	COG0778	Nitroreductase
TL08_05710	COG0596	Alpha beta hydrolase
TL08_05715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TL08_05720	COG0736	holo-[acyl-carrier-protein] synthase activity
TL08_05745	COG1131	(ABC) transporter
TL08_05750	COG0842	Transport permease protein
TL08_05750	COG1511	domain protein
TL08_05755	COG0842	Transport permease protein
TL08_05810	COG0596	Alpha beta hydrolase
TL08_05820	COG2197	response regulator
TL08_05830	COG3831	ATPase activity
TL08_05835	COG0596	Alpha beta hydrolase
TL08_05870	COG2226	methyltransferase
TL08_05925	COG2226	methyltransferase
TL08_05960	COG2124	cytochrome p450
TL08_05970	COG1937	Protein conserved in bacteria
TL08_05975	COG2217	Heavy metal translocating P-type atpase
TL08_06005	COG0110	maltose O-acetyltransferase activity
TL08_06015	COG0477	Major facilitator Superfamily
TL08_06025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TL08_06025	COG2124	cytochrome p450
TL08_06040	COG1733	regulation of RNA biosynthetic process
TL08_06045	COG4335	DNA alkylation repair
TL08_06060	COG0006	proline dipeptidase activity
TL08_06070	COG0659	secondary active sulfate transmembrane transporter activity
TL08_06075	COG0789	Transcriptional regulator
TL08_06085	COG1309	transcriptional regulator
TL08_06090	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_06170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_06185	COG1846	Transcriptional regulator
TL08_06205	COG3639	organic phosphonate transmembrane transporter activity
TL08_06210	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TL08_06215	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TL08_06225	COG2188	Transcriptional regulator
TL08_06230	COG1063	alcohol dehydrogenase
TL08_06260	COG1276	copper resistance
TL08_06260	COG2372	response to copper ion
TL08_06280	COG4221	oxidoreductase activity
TL08_06285	COG1309	transcriptional regulator
TL08_06310	COG3397	chitin binding
TL08_06350	COG0484	heat shock protein binding
TL08_06370	COG1136	(ABC) transporter
TL08_06375	COG0577	efflux transmembrane transporter activity
TL08_06385	COG1733	regulation of RNA biosynthetic process
TL08_06430	COG0560	Phosphoserine phosphatase
TL08_06430	COG3830	Belongs to the UPF0237 family
TL08_06450	COG1335	isochorismatase
TL08_06460	COG1063	alcohol dehydrogenase
TL08_06470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TL08_06485	COG3191	aminopeptidase activity
TL08_06530	COG0598	Magnesium transport protein CorA
TL08_06535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TL08_06540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TL08_06555	COG0058	SHG alpha-glucan phosphorylase activity
TL08_06560	COG0739	heme binding
TL08_06605	COG1119	ATPase activity
TL08_06610	COG1024	Enoyl-CoA hydratase
TL08_06625	COG0110	maltose O-acetyltransferase activity
TL08_06650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_06655	COG0488	(ABC) transporter
TL08_06680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TL08_06690	COG0482	sulfurtransferase activity
TL08_06705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_06715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_06730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_06775	COG1414	Transcriptional regulator
TL08_06785	COG4638	Rieske (2fe-2S)
TL08_06795	COG5297	Belongs to the glycosyl hydrolase family 6
TL08_06825	COG4585	Histidine kinase
TL08_06830	COG2197	response regulator
TL08_06835	COG2267	carboxylic ester hydrolase activity
TL08_06870	COG1082	Xylose isomerase domain protein TIM barrel
TL08_06895	COG1376	ErfK ybiS ycfS ynhG family protein
TL08_06905	COG0402	S-adenosylhomocysteine deaminase activity
TL08_06915	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_06925	COG0596	Alpha beta hydrolase
TL08_06930	COG1595	DNA-templated transcription, initiation
TL08_06950	COG1131	(ABC) transporter
TL08_06975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TL08_06990	COG0318	PFAM AMP-dependent synthetase and ligase
TL08_07040	COG1175	transmembrane transport
TL08_07050	COG2723	6-phospho-beta-galactosidase activity
TL08_07055	COG2318	DinB family
TL08_07065	COG2267	carboxylic ester hydrolase activity
TL08_07090	COG2197	response regulator
TL08_07170	COG2814	Major facilitator Superfamily
TL08_07195	COG1917	Cupin 2, conserved barrel domain protein
TL08_07215	COG1309	transcriptional regulator
TL08_07230	COG0018	arginyl-trna synthetase
TL08_07235	COG0019	diaminopimelate decarboxylase activity
TL08_07240	COG0460	homoserine dehydrogenase
TL08_07245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TL08_07250	COG0083	homoserine kinase activity
TL08_07255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TL08_07255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TL08_07265	COG0254	rRNA binding
TL08_07270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TL08_07280	COG2890	protein-(glutamine-N5) methyltransferase activity
TL08_07290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TL08_07295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TL08_07305	COG0356	it plays a direct role in the translocation of protons across the membrane
TL08_07315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TL08_07320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TL08_07325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TL08_07330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TL08_07335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TL08_07360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TL08_07375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TL08_07385	COG0765	amino acid transport
TL08_07390	COG0765	amino acid transport
TL08_07395	COG1126	abc transporter atp-binding protein
TL08_07410	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TL08_07435	COG2376	Dihydroxyacetone kinase
TL08_07440	COG1461	Dihydroxyacetone kinase
TL08_07460	COG0346	lactoylglutathione lyase activity
TL08_07470	COG0183	Belongs to the thiolase family
TL08_07485	COG2409	Drug exporters of the RND superfamily
TL08_07490	COG1846	Transcriptional regulator
TL08_07525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TL08_07530	COG0366	Alpha amylase catalytic
TL08_07560	COG2608	mercury ion transmembrane transporter activity
TL08_07580	COG1472	Belongs to the glycosyl hydrolase 3 family
TL08_07585	COG1609	Transcriptional regulator
TL08_07600	COG4209	transmembrane transport
TL08_07605	COG0395	ABC-type sugar transport system, permease component
TL08_07620	COG0640	Transcriptional regulator
TL08_07635	COG2272	Belongs to the type-B carboxylesterase lipase family
TL08_07675	COG3629	intracellular signal transduction
TL08_07720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_07745	COG2205	protein histidine kinase activity
TL08_07750	COG0745	RESPONSE REGULATOR receiver
TL08_07765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_07775	COG1741	Belongs to the pirin family
TL08_07800	COG2197	response regulator
TL08_07810	COG0596	Alpha beta hydrolase
TL08_07840	COG2902	Dehydrogenase
TL08_07855	COG0366	Alpha amylase catalytic
TL08_07865	COG0668	transmembrane transport
TL08_07895	COG1505	serine-type exopeptidase activity
TL08_07915	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TL08_07925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TL08_07975	COG4552	Acetyltransferase involved in intracellular survival and related
TL08_08005	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TL08_08035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TL08_08045	COG0544	peptidyl-prolyl cis-trans isomerase activity
TL08_08050	COG0740	serine-type endopeptidase activity
TL08_08055	COG0740	serine-type endopeptidase activity
TL08_08060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TL08_08075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TL08_08100	COG0525	valine-tRNA ligase activity
TL08_08105	COG0285	dihydrofolate synthase activity
TL08_08115	COG0105	UTP biosynthetic process
TL08_08120	COG1131	(ABC) transporter
TL08_08130	COG0842	Transport permease protein
TL08_08140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TL08_08155	COG1530	ribonuclease E activity
TL08_08155	COG1530	ribonuclease E activity
TL08_08160	COG3842	ATPase activity
TL08_08180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TL08_08185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TL08_08190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TL08_08195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TL08_08205	COG0514	ATP-dependent DNA helicase (RecQ)
TL08_08210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TL08_08225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TL08_08230	COG0799	negative regulation of ribosome biogenesis
TL08_08235	COG0406	alpha-ribazole phosphatase activity
TL08_08240	COG2755	lipolytic protein G-D-S-L family
TL08_08245	COG1307	EDD domain protein, DegV family
TL08_08250	COG1596	polysaccharide export
TL08_08250	COG1555	photosystem II stabilization
TL08_08270	COG0268	Binds directly to 16S ribosomal RNA
TL08_08285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TL08_08295	COG0346	lactoylglutathione lyase activity
TL08_08310	COG1490	D-aminoacyl-tRNA deacylase activity
TL08_08315	COG0204	Acyl-transferase
TL08_08315	COG0318	PFAM AMP-dependent synthetase and ligase
TL08_08330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TL08_08335	COG2313	pseudouridylate synthase activity
TL08_08365	COG4214	carbohydrate transport
TL08_08370	COG1940	carbohydrate kinase activity
TL08_08385	COG1940	carbohydrate kinase activity
TL08_08390	COG0483	inositol monophosphate 1-phosphatase activity
TL08_08410	COG0756	dUTP diphosphatase activity
TL08_08435	COG0569	domain protein
TL08_08440	COG0531	amino acid
TL08_08445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TL08_08450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TL08_08455	COG0745	RESPONSE REGULATOR receiver
TL08_08460	COG2205	protein histidine kinase activity
TL08_08465	COG1231	oxidoreductase activity
TL08_08475	COG0481	GTPase activity
TL08_08480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TL08_08485	COG2137	regulation of response to DNA damage stimulus
TL08_08495	COG0800	Aldolase
TL08_08515	COG0765	amino acid transport
TL08_08520	COG0765	amino acid transport
TL08_08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL08_08530	COG1126	abc transporter atp-binding protein
TL08_08535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TL08_08545	COG1196	nuclear chromosome segregation
TL08_08555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TL08_08570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TL08_08580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TL08_08590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TL08_08630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TL08_08635	COG3395	kinase activity
TL08_08655	COG1506	peptidase
TL08_08655	COG0823	Involved in the tonB-independent uptake of proteins
TL08_08665	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TL08_08675	COG2897	thiosulfate sulfurtransferase activity
TL08_08685	COG0123	including yeast histone deacetylase and acetoin utilization protein
TL08_08690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TL08_08700	COG5002	protein histidine kinase activity
TL08_08705	COG0745	RESPONSE REGULATOR receiver
TL08_08720	COG3265	gluconokinase activity
TL08_08760	COG0228	four-way junction DNA binding
TL08_08770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TL08_08775	COG0336	Belongs to the RNA methyltransferase TrmD family
TL08_08780	COG0335	large ribosomal subunit rRNA binding
TL08_08785	COG0681	Belongs to the peptidase S26 family
TL08_08790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TL08_08810	COG0601	transmembrane transport
TL08_08815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_08820	COG0444	Belongs to the ABC transporter superfamily
TL08_08825	COG4172	Belongs to the ABC transporter superfamily
TL08_08835	COG1940	carbohydrate kinase activity
TL08_08840	COG0792	nuclease activity
TL08_08845	COG0606	chelatase, subunit chli
TL08_08860	COG1191	sigma factor activity
TL08_08870	COG0052	Belongs to the universal ribosomal protein uS2 family
TL08_08875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TL08_08880	COG0528	UMP kinase activity
TL08_08885	COG0233	cytoplasmic translational termination
TL08_08895	COG2226	methyltransferase
TL08_08900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TL08_08915	COG3842	ATPase activity
TL08_08925	COG1176	ABC-type spermidine putrescine transport system, permease component I
TL08_08930	COG1177	transmembrane transport
TL08_08935	COG2261	transglycosylase associated protein
TL08_08940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TL08_08950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TL08_08955	COG0456	acetyltransferase
TL08_08975	COG1492	cobalamin metabolic process
TL08_09000	COG2186	Transcriptional regulator
TL08_09025	COG1881	PFAM PEBP family protein
TL08_09035	COG4585	Histidine kinase
TL08_09040	COG2197	response regulator
TL08_09060	COG3226	Transcriptional regulator
TL08_09065	COG2814	Major facilitator Superfamily
TL08_09090	COG2124	cytochrome p450
TL08_09100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TL08_09100	COG1648	precorrin-2 dehydrogenase activity
TL08_09105	COG0513	Belongs to the DEAD box helicase family
TL08_09115	COG3022	response to hydroperoxide
TL08_09125	COG0442	prolyl-tRNA aminoacylation
TL08_09135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_09165	COG0779	Required for maturation of 30S ribosomal subunits
TL08_09180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TL08_09190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TL08_09195	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_09200	COG3153	acetyltransferase
TL08_09230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TL08_09265	COG2146	nitrite reductase [NAD(P)H] activity
TL08_09265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TL08_09270	COG2223	nitrite transmembrane transporter activity
TL08_09275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TL08_09280	COG0243	molybdopterin cofactor binding
TL08_09285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TL08_09290	COG1185	polyribonucleotide nucleotidyltransferase activity
TL08_09295	COG0612	Peptidase, M16
TL08_09300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TL08_09335	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TL08_09340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_09345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TL08_09350	COG1674	ftsk spoiiie
TL08_09360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TL08_09370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TL08_09380	COG1546	Belongs to the CinA family
TL08_09380	COG1058	Belongs to the CinA family
TL08_09385	COG1396	sequence-specific DNA binding
TL08_09405	COG2233	PERMEase
TL08_09410	COG1192	Involved in chromosome partitioning
TL08_09435	COG0714	Associated with various cellular activities
TL08_09440	COG2001	Belongs to the MraZ family
TL08_09445	COG0275	rRNA processing
TL08_09455	COG0768	penicillin binding
TL08_09470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TL08_09475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TL08_09485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TL08_09490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TL08_09495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TL08_09500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_09510	COG1984	allophanate hydrolase subunit 2
TL08_09520	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TL08_09525	COG1070	Carbohydrate kinase
TL08_09540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TL08_09545	COG1799	cell septum assembly
TL08_09560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TL08_09605	COG2124	cytochrome p450
TL08_09610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TL08_09615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TL08_09625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TL08_09645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TL08_09650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TL08_09680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TL08_09685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TL08_09690	COG2318	DinB family
TL08_09695	COG1252	NADH dehydrogenase
TL08_09700	COG1595	DNA-templated transcription, initiation
TL08_09705	COG0131	Imidazoleglycerol-phosphate dehydratase
TL08_09715	COG0789	Transcriptional regulator
TL08_09720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TL08_09730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TL08_09745	COG0107	imidazoleglycerol-phosphate synthase activity
TL08_09755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TL08_09760	COG1309	transcriptional regulator
TL08_09765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TL08_09780	COG0134	indole-3-glycerol-phosphate synthase activity
TL08_09785	COG0133	tryptophan synthase activity
TL08_09790	COG0159	tryptophan synthase activity
TL08_09800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TL08_09815	COG1160	GTP binding
TL08_09825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_09835	COG2188	Transcriptional regulator
TL08_09840	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TL08_09845	COG1280	lysine exporter protein (LysE YggA)
TL08_09850	COG1522	sequence-specific DNA binding
TL08_09900	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_09905	COG0179	Fumarylacetoacetate (FAA) hydrolase
TL08_09930	COG4941	Belongs to the sigma-70 factor family
TL08_09945	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TL08_09950	COG0671	phosphoesterase, PA-phosphatase related
TL08_09960	COG0739	heme binding
TL08_09960	COG1196	nuclear chromosome segregation
TL08_09960	COG0741	lytic transglycosylase activity
TL08_09970	COG1522	sequence-specific DNA binding
TL08_10030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_10090	COG0514	ATP-dependent DNA helicase (RecQ)
TL08_10095	COG1764	response to oxidative stress
TL08_10150	COG1674	ftsk spoiiie
TL08_10205	COG0411	ABC transporter
TL08_10210	COG0410	ABC transporter
TL08_10215	COG2050	protein possibly involved in aromatic compounds catabolism
TL08_10245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_10250	COG0539	negative regulation of cytoplasmic translation
TL08_10255	COG2755	lipolytic protein G-D-S-L family
TL08_10255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TL08_10260	COG2755	lipolytic protein G-D-S-L family
TL08_10260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TL08_10265	COG0237	dephospho-CoA kinase activity
TL08_10265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TL08_10300	COG0861	Integral membrane protein TerC family
TL08_10305	COG4946	Tricorn protease homolog
TL08_10305	COG1506	peptidase
TL08_10305	COG0823	Involved in the tonB-independent uptake of proteins
TL08_10335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TL08_10350	COG1560	Kdo2-lipid A biosynthetic process
TL08_10360	COG1051	belongs to the nudix hydrolase family
TL08_10375	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TL08_10380	COG1396	sequence-specific DNA binding
TL08_10395	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TL08_10400	COG0217	transcriptional regulatory protein
TL08_10415	COG3903	Transcriptional regulator
TL08_10415	COG3629	intracellular signal transduction
TL08_10435	COG2084	Dehydrogenase
TL08_10445	COG0475	glutathione-regulated potassium exporter activity
TL08_10465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_10470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_10475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_10510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TL08_10515	COG0632	four-way junction helicase activity
TL08_10520	COG2255	four-way junction helicase activity
TL08_10530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TL08_10535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TL08_10580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TL08_10585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TL08_10600	COG1404	Belongs to the peptidase S8 family
TL08_10600	COG4412	M6 family metalloprotease domain protein
TL08_10605	COG4412	M6 family metalloprotease domain protein
TL08_10605	COG1404	Belongs to the peptidase S8 family
TL08_10635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TL08_10640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TL08_10640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TL08_10645	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL08_10650	COG1121	(ABC) transporter
TL08_10655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_10660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_10665	COG2132	Multicopper oxidase
TL08_10670	COG1309	transcriptional regulator
TL08_10685	COG1607	acyl-coa hydrolase
TL08_10705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TL08_10745	COG1716	ATPase activity
TL08_10765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TL08_10765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TL08_10770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TL08_10795	COG1309	transcriptional regulator
TL08_10800	COG3572	ergothioneine biosynthetic process
TL08_10805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TL08_10810	COG0121	glutamine amidotransferase
TL08_10815	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TL08_10835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TL08_10850	COG0791	NLP P60 protein
TL08_10850	COG3883	PFAM NLP P60 protein
TL08_10860	COG0583	DNA-binding transcription factor activity
TL08_10865	COG0697	spore germination
TL08_10875	COG0714	Associated with various cellular activities
TL08_10890	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_10895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TL08_10935	COG1012	belongs to the aldehyde dehydrogenase family
TL08_10980	COG2186	Transcriptional regulator
TL08_11000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL08_11025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TL08_11030	COG0183	Belongs to the thiolase family
TL08_11035	COG1253	flavin adenine dinucleotide binding
TL08_11050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TL08_11055	COG0438	transferase activity, transferring glycosyl groups
TL08_11100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TL08_11105	COG0542	response to heat
TL08_11165	COG2186	Transcriptional regulator
TL08_11170	COG3401	FG-GAP repeat protein
TL08_11190	COG3618	amidohydrolase
TL08_11230	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_11235	COG0022	dehydrogenase e1 component
TL08_11240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TL08_11265	COG1643	Atp-dependent helicase
TL08_11305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TL08_11315	COG0662	Cupin 2, conserved barrel domain protein
TL08_11360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TL08_11380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TL08_11390	COG1263	PTS System
TL08_11390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL08_11400	COG1263	PTS System
TL08_11400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TL08_11405	COG2190	(PTS) system
TL08_11415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TL08_11420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TL08_11430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TL08_11435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TL08_11455	COG0006	proline dipeptidase activity
TL08_11460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TL08_11465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TL08_11480	COG0540	Belongs to the ATCase OTCase family
TL08_11495	COG0505	Belongs to the CarA family
TL08_11505	COG0284	orotidine-5'-phosphate decarboxylase activity
TL08_11515	COG0194	GDP metabolic process
TL08_11520	COG1758	RNA polymerase activity
TL08_11530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TL08_11550	COG2226	methyltransferase
TL08_11565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TL08_11570	COG0242	peptide deformylase activity
TL08_11585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TL08_11585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TL08_11590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TL08_11605	COG0322	excinuclease ABC activity
TL08_11610	COG1660	Displays ATPase and GTPase activities
TL08_11620	COG1481	regulation of sporulation
TL08_11625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TL08_11630	COG0126	phosphoglycerate kinase activity
TL08_11635	COG0149	triose-phosphate isomerase activity
TL08_11640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TL08_11650	COG1595	DNA-templated transcription, initiation
TL08_11655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TL08_11660	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_11675	COG0363	glucosamine-6-phosphate deaminase activity
TL08_11690	COG0166	Belongs to the GPI family
TL08_11695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TL08_11705	COG0109	protoheme IX farnesyltransferase activity
TL08_11750	COG1131	(ABC) transporter
TL08_11755	COG2197	response regulator
TL08_11760	COG4585	Histidine kinase
TL08_11775	COG1510	regulation of RNA biosynthetic process
TL08_11790	COG1131	(ABC) transporter
TL08_11820	COG0396	ATPase activity
TL08_11830	COG0822	iron-sulfur transferase activity
TL08_11835	COG2151	metal-sulfur cluster biosynthetic enzyme
TL08_11855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TL08_11875	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TL08_11890	COG0488	(ABC) transporter
TL08_11900	COG1024	Enoyl-CoA hydratase
TL08_11910	COG1733	regulation of RNA biosynthetic process
TL08_11935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TL08_11935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TL08_11955	COG0142	geranyltranstransferase activity
TL08_11960	COG2264	protein methyltransferase activity
TL08_11965	COG0140	phosphoribosyl-ATP diphosphatase activity
TL08_11970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TL08_11975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TL08_12005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TL08_12015	COG0517	IMP dehydrogenase activity
TL08_12015	COG1994	Peptidase M50
TL08_12040	COG1222	aaa ATPase
TL08_12065	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_12070	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_12085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_12095	COG2378	regulation of single-species biofilm formation
TL08_12160	COG1136	(ABC) transporter
TL08_12170	COG3030	protein affecting phage T7 exclusion by the F plasmid
TL08_12190	COG0745	RESPONSE REGULATOR receiver
TL08_12240	COG3845	ABC transporter
TL08_12285	COG0515	serine threonine protein kinase
TL08_12285	COG2815	serine threonine protein kinase
TL08_12295	COG3285	dna ligase
TL08_12295	COG1793	dna ligase
TL08_12320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TL08_12330	COG0385	Bile acid
TL08_12340	COG3629	intracellular signal transduction
TL08_12340	COG3903	Transcriptional regulator
TL08_12345	COG4607	ABC-type enterochelin transport system periplasmic component
TL08_12350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_12355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_12360	COG1120	ATPase activity
TL08_12365	COG1132	(ABC) transporter
TL08_12370	COG1132	(ABC) transporter
TL08_12405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TL08_12410	COG1309	transcriptional regulator
TL08_12430	COG1879	ABC-type sugar transport system periplasmic component
TL08_12435	COG1129	ABC transporter
TL08_12440	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_12445	COG1063	alcohol dehydrogenase
TL08_12460	COG2186	Transcriptional regulator
TL08_12465	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_12470	COG0800	Aldolase
TL08_12475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TL08_12500	COG2267	carboxylic ester hydrolase activity
TL08_12505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_12525	COG2814	Major facilitator Superfamily
TL08_12545	COG1960	acyl-CoA dehydrogenase activity
TL08_12555	COG4221	oxidoreductase activity
TL08_12575	COG0411	ABC transporter
TL08_12580	COG0559	Belongs to the binding-protein-dependent transport system permease family
TL08_12585	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_12595	COG1960	acyl-CoA dehydrogenase activity
TL08_12600	COG0318	PFAM AMP-dependent synthetase and ligase
TL08_12605	COG0604	alcohol dehydrogenase
TL08_12630	COG0183	Belongs to the thiolase family
TL08_12655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TL08_12660	COG1116	anion transmembrane transporter activity
TL08_12665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_12675	COG1733	regulation of RNA biosynthetic process
TL08_12690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_12700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TL08_12705	COG0235	Class ii aldolase
TL08_12710	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TL08_12725	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TL08_12775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_12780	COG0601	transmembrane transport
TL08_12785	COG0747	negative chemotaxis
TL08_12795	COG0431	NADPH-dependent FMN reductase
TL08_12800	COG1309	transcriptional regulator
TL08_12805	COG1132	(ABC) transporter
TL08_12825	COG2018	Roadblock/LC7 domain
TL08_12880	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_12890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TL08_12905	COG0477	Major facilitator Superfamily
TL08_12910	COG0028	Belongs to the TPP enzyme family
TL08_12915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TL08_12930	COG1012	belongs to the aldehyde dehydrogenase family
TL08_13010	COG0673	inositol 2-dehydrogenase activity
TL08_13015	COG1116	anion transmembrane transporter activity
TL08_13025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_13055	COG0477	Major facilitator Superfamily
TL08_13070	COG0747	negative chemotaxis
TL08_13075	COG0601	transmembrane transport
TL08_13080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_13100	COG1278	Cold shock
TL08_13120	COG1619	proteins homologs of microcin C7 resistance protein MccF
TL08_13190	COG0215	cysteine-tRNA ligase activity
TL08_13200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TL08_13210	COG1410	methionine synthase
TL08_13210	COG0646	methionine synthase
TL08_13215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TL08_13220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_13225	COG0372	Belongs to the citrate synthase family
TL08_13230	COG0372	Belongs to the citrate synthase family
TL08_13235	COG1515	deoxyribonuclease V activity
TL08_13240	COG0242	peptide deformylase activity
TL08_13250	COG0477	Major facilitator Superfamily
TL08_13255	COG1132	(ABC) transporter
TL08_13270	COG1653	transport
TL08_13285	COG0235	Class ii aldolase
TL08_13290	COG3395	kinase activity
TL08_13305	COG1349	DNA-binding transcription factor activity
TL08_13315	COG1309	transcriptional regulator
TL08_13330	COG0659	secondary active sulfate transmembrane transporter activity
TL08_13355	COG2814	Major facilitator Superfamily
TL08_13370	COG0076	glutamate decarboxylase activity
TL08_13395	COG0277	FAD linked oxidase domain protein
TL08_13410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_13425	COG1755	Isoprenylcysteine carboxyl methyltransferase
TL08_13450	COG0395	ABC-type sugar transport system, permease component
TL08_13455	COG1175	transmembrane transport
TL08_13505	COG2267	carboxylic ester hydrolase activity
TL08_13555	COG2130	NADP-dependent
TL08_13560	COG2375	cellular response to nickel ion
TL08_13575	COG2391	methyltransferase activity
TL08_13595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TL08_13600	COG2011	ABC-type metal ion transport system permease component
TL08_13605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TL08_13620	COG0431	NADPH-dependent FMN reductase
TL08_13625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_13655	COG1653	transport
TL08_13660	COG1175	transmembrane transport
TL08_13685	COG3507	Belongs to the glycosyl hydrolase 43 family
TL08_13695	COG0009	L-threonylcarbamoyladenylate synthase
TL08_13700	COG1120	ATPase activity
TL08_13705	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_13710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_13735	COG2027	D-alanyl-D-alanine carboxypeptidase
TL08_13740	COG0488	(ABC) transporter
TL08_13745	COG1063	alcohol dehydrogenase
TL08_13755	COG0400	carboxylic ester hydrolase activity
TL08_13760	COG0346	lactoylglutathione lyase activity
TL08_13765	COG1846	Transcriptional regulator
TL08_13770	COG1649	PFAM Uncharacterised BCR, COG1649
TL08_13785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TL08_13835	COG0667	Aldo Keto reductase
TL08_13845	COG2226	methyltransferase
TL08_13850	COG0488	(ABC) transporter
TL08_13855	COG1739	Uncharacterized protein family UPF0029
TL08_13910	COG0463	Glycosyl transferase, family 2
TL08_13920	COG1435	thymidine kinase activity
TL08_13940	COG3300	MHYT domain
TL08_13940	COG5001	Diguanylate cyclase
TL08_13990	COG1132	(ABC) transporter
TL08_14015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TL08_14025	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_14055	COG1846	Transcriptional regulator
TL08_14080	COG0702	epimerase
TL08_14085	COG1733	regulation of RNA biosynthetic process
TL08_14100	COG1309	transcriptional regulator
TL08_14110	COG2267	carboxylic ester hydrolase activity
TL08_14115	COG1357	PFAM Pentapeptide repeats (8 copies)
TL08_14120	COG1309	transcriptional regulator
TL08_14150	COG1309	transcriptional regulator
TL08_14170	COG0739	heme binding
TL08_14185	COG0154	amidase activity
TL08_14190	COG1309	transcriptional regulator
TL08_14215	COG2890	protein-(glutamine-N5) methyltransferase activity
TL08_14250	COG2249	NAD(P)H dehydrogenase (quinone) activity
TL08_14265	COG1846	Transcriptional regulator
TL08_14270	COG1968	undecaprenyl-diphosphatase activity
TL08_14275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_14355	COG1201	RNA secondary structure unwinding
TL08_14405	COG1169	isochorismate synthase
TL08_14435	COG3433	isochorismatase activity
TL08_14435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_14435	COG2226	methyltransferase
TL08_14445	COG1021	2,3-dihydroxybenzoate-AMP ligase
TL08_14525	COG2197	response regulator
TL08_14530	COG1733	regulation of RNA biosynthetic process
TL08_14635	COG2226	methyltransferase
TL08_14685	COG3012	SEC-C Motif Domain Protein
TL08_14710	COG1609	Transcriptional regulator
TL08_14725	COG0300	oxidoreductase activity
TL08_14740	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_14745	COG1309	transcriptional regulator
TL08_14750	COG3938	Belongs to the proline racemase family
TL08_14770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TL08_14775	COG1802	Transcriptional regulator
TL08_14795	COG0444	Belongs to the ABC transporter superfamily
TL08_14800	COG0601	transmembrane transport
TL08_14805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TL08_14810	COG0747	negative chemotaxis
TL08_14840	COG1051	belongs to the nudix hydrolase family
TL08_14840	COG1056	cytidyltransferase-related domain
TL08_14845	COG1051	belongs to the nudix hydrolase family
TL08_14845	COG1056	cytidyltransferase-related domain
TL08_14890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_14900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TL08_14910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TL08_14915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TL08_14930	COG1309	transcriptional regulator
TL08_14935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TL08_14940	COG3401	FG-GAP repeat protein
TL08_14955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TL08_14960	COG3181	Tripartite tricarboxylate transporter family receptor
TL08_14975	COG0583	DNA-binding transcription factor activity
TL08_14990	COG0326	Molecular chaperone. Has ATPase activity
TL08_14995	COG0300	oxidoreductase activity
TL08_15020	COG1609	Transcriptional regulator
TL08_15035	COG0395	ABC-type sugar transport system, permease component
TL08_15045	COG2272	Belongs to the type-B carboxylesterase lipase family
TL08_15055	COG2197	response regulator
TL08_15065	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TL08_15070	COG3629	intracellular signal transduction
TL08_15070	COG3903	Transcriptional regulator
TL08_15075	COG0596	Alpha beta hydrolase
TL08_15100	COG0346	lactoylglutathione lyase activity
TL08_15125	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_15140	COG1032	radical SAM domain protein
TL08_15165	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_15170	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_15175	COG1129	ABC transporter
TL08_15180	COG1879	ABC-type sugar transport system periplasmic component
TL08_15190	COG3250	beta-galactosidase activity
TL08_15195	COG1349	DNA-binding transcription factor activity
TL08_15205	COG2197	response regulator
TL08_15220	COG3629	intracellular signal transduction
TL08_15220	COG3903	Transcriptional regulator
TL08_15225	COG0667	Aldo Keto reductase
TL08_15265	COG0564	pseudouridine synthase activity
TL08_15325	COG0739	heme binding
TL08_15350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TL08_15355	COG3959	Transketolase, thiamine diphosphate binding domain
TL08_15360	COG3958	Transketolase
TL08_15385	COG2182	Extracellular solute-binding protein
TL08_15390	COG1175	transmembrane transport
TL08_15400	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_15425	COG0740	serine-type endopeptidase activity
TL08_15430	COG0583	DNA-binding transcription factor activity
TL08_15435	COG0697	spore germination
TL08_15445	COG1609	Transcriptional regulator
TL08_15455	COG0673	inositol 2-dehydrogenase activity
TL08_15485	COG0395	ABC-type sugar transport system, permease component
TL08_15490	COG1175	transmembrane transport
TL08_15535	COG0346	lactoylglutathione lyase activity
TL08_15540	COG0640	Transcriptional regulator
TL08_15550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TL08_15560	COG0456	acetyltransferase
TL08_15560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TL08_15590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TL08_15595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_15610	COG0653	protein targeting
TL08_15615	COG0702	epimerase
TL08_15635	COG3340	Belongs to the peptidase S51 family
TL08_15680	COG1785	Belongs to the alkaline phosphatase family
TL08_15690	COG0477	Major facilitator Superfamily
TL08_15720	COG1309	transcriptional regulator
TL08_15730	COG3831	ATPase activity
TL08_15750	COG0028	Belongs to the TPP enzyme family
TL08_15755	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_15760	COG0247	lactate metabolic process
TL08_15760	COG0277	FAD linked oxidase domain protein
TL08_15785	COG0235	Class ii aldolase
TL08_15825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_15835	COG0697	spore germination
TL08_15840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_15855	COG3959	Transketolase, thiamine diphosphate binding domain
TL08_15905	COG2124	cytochrome p450
TL08_16040	COG2132	Multicopper oxidase
TL08_16060	COG4555	ABC transporter
TL08_16090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TL08_16095	COG2409	Drug exporters of the RND superfamily
TL08_16105	COG0789	Transcriptional regulator
TL08_16110	COG0300	oxidoreductase activity
TL08_16115	COG2197	response regulator
TL08_16130	COG1131	(ABC) transporter
TL08_16155	COG0277	FAD linked oxidase domain protein
TL08_16160	COG0579	oxidoreductase
TL08_16190	COG2814	Major facilitator Superfamily
TL08_16235	COG0477	Major facilitator Superfamily
TL08_16265	COG1414	Transcriptional regulator
TL08_16280	COG0477	Major facilitator Superfamily
TL08_16290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_16295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TL08_16305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TL08_16335	COG0577	efflux transmembrane transporter activity
TL08_16335	COG1136	(ABC) transporter
TL08_16340	COG2177	Part of the ABC transporter FtsEX involved in
TL08_16345	COG0137	argininosuccinate synthase activity
TL08_16360	COG2197	response regulator
TL08_16385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TL08_16400	COG3510	cephalosporin hydroxylase
TL08_16405	COG3537	Alpha-1,2-mannosidase
TL08_16410	COG0028	Belongs to the TPP enzyme family
TL08_16485	COG0738	Major facilitator superfamily
TL08_16495	COG0738	Major facilitator superfamily
TL08_16500	COG3226	Transcriptional regulator
TL08_16510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_16555	COG0667	Aldo Keto reductase
TL08_16575	COG0596	Alpha beta hydrolase
TL08_16640	COG0583	DNA-binding transcription factor activity
TL08_16650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_16660	COG1505	serine-type exopeptidase activity
TL08_16665	COG2130	NADP-dependent
TL08_16675	COG5640	endopeptidase activity
TL08_16685	COG1733	regulation of RNA biosynthetic process
TL08_16705	COG0247	lactate metabolic process
TL08_16705	COG0277	FAD linked oxidase domain protein
TL08_16740	COG1105	Belongs to the carbohydrate kinase PfkB family
TL08_16745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TL08_16750	COG2814	Major facilitator Superfamily
TL08_16755	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TL08_16765	COG3831	ATPase activity
TL08_16790	COG3831	ATPase activity
TL08_16795	COG3831	ATPase activity
TL08_16800	COG0714	Associated with various cellular activities
TL08_16805	COG2425	protein containing a von Willebrand factor type A (vWA) domain
TL08_16810	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TL08_16815	COG4715	Zinc finger, swim domain protein
TL08_16855	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TL08_16865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TL08_16910	COG2706	6-phosphogluconolactonase activity
TL08_16915	COG0251	oxidation-reduction process
TL08_16920	COG1921	L-seryl-tRNASec selenium transferase activity
TL08_16935	COG3842	ATPase activity
TL08_17005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TL08_17030	COG3619	membrane
TL08_17070	COG0702	epimerase
TL08_17075	COG0515	serine threonine protein kinase
TL08_17075	COG2815	serine threonine protein kinase
TL08_17100	COG2124	cytochrome p450
TL08_17135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_17140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_17215	COG0640	Transcriptional regulator
TL08_17220	COG0798	PFAM Bile acid sodium symporter
TL08_17240	COG1278	Cold shock
TL08_17265	COG4565	transcriptional regulatory protein
TL08_17270	COG3290	protein histidine kinase activity
TL08_17275	COG1301	dicarboxylic acid transport
TL08_17280	COG0739	heme binding
TL08_17290	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TL08_17385	COG1432	Conserved Protein
TL08_17390	COG1063	alcohol dehydrogenase
TL08_17395	COG0247	lactate metabolic process
TL08_17405	COG1556	Lactate utilization protein
TL08_17415	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_17440	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_17445	COG1129	ABC transporter
TL08_17520	COG0525	valine-tRNA ligase activity
TL08_17525	COG1136	(ABC) transporter
TL08_17525	COG0577	efflux transmembrane transporter activity
TL08_17530	COG1136	(ABC) transporter
TL08_17530	COG0577	efflux transmembrane transporter activity
TL08_17560	COG0464	growth
TL08_17575	COG2197	response regulator
TL08_17590	COG3903	Transcriptional regulator
TL08_17590	COG3629	intracellular signal transduction
TL08_17625	COG1846	Transcriptional regulator
TL08_17630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TL08_17640	COG1082	Xylose isomerase domain protein TIM barrel
TL08_17650	COG5297	Belongs to the glycosyl hydrolase family 6
TL08_17650	COG4733	cellulase activity
TL08_17660	COG2723	6-phospho-beta-galactosidase activity
TL08_17665	COG0395	ABC-type sugar transport system, permease component
TL08_17690	COG1620	l-lactate permease
TL08_17700	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_17705	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TL08_17715	COG0254	rRNA binding
TL08_17720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TL08_17730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TL08_17735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TL08_17740	COG0656	L-ascorbic acid biosynthetic process
TL08_17750	COG0438	transferase activity, transferring glycosyl groups
TL08_17755	COG1309	transcriptional regulator
TL08_17760	COG4133	protoheme IX ABC transporter activity
TL08_17780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TL08_17785	COG0739	heme binding
TL08_17805	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TL08_17810	COG0473	3-isopropylmalate dehydrogenase activity
TL08_17815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL08_17820	COG0586	Pfam SNARE associated Golgi protein
TL08_17825	COG0659	secondary active sulfate transmembrane transporter activity
TL08_17845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TL08_17855	COG1946	Acyl-CoA thioesterase
TL08_17870	COG2234	aminopeptidase activity
TL08_17885	COG0069	glutamate synthase activity
TL08_17885	COG0067	glutamate synthase
TL08_17885	COG0070	glutamate synthase
TL08_17890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TL08_17895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_17900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TL08_17910	COG0475	glutathione-regulated potassium exporter activity
TL08_17915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TL08_17945	COG1012	belongs to the aldehyde dehydrogenase family
TL08_17960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TL08_17965	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TL08_17990	COG4585	Histidine kinase
TL08_17995	COG2197	response regulator
TL08_18015	COG0494	nUDIX hydrolase
TL08_18020	COG0504	CTP synthase activity
TL08_18040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TL08_18055	COG0647	UMP catabolic process
TL08_18090	COG2094	Belongs to the DNA glycosylase MPG family
TL08_18095	COG0165	Argininosuccinate lyase
TL08_18100	COG1438	arginine binding
TL08_18105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TL08_18115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TL08_18120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TL08_18125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TL08_18150	COG2855	membrane
TL08_18155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TL08_18155	COG0072	phenylalanine-tRNA ligase activity
TL08_18160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TL08_18175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_18180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TL08_18185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TL08_18215	COG1309	transcriptional regulator
TL08_18220	COG0574	Belongs to the PEP-utilizing enzyme family
TL08_18220	COG3848	Pyruvate phosphate dikinase
TL08_18225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TL08_18235	COG0328	RNA-DNA hybrid ribonuclease activity
TL08_18245	COG2356	endonuclease I
TL08_18305	COG0494	nUDIX hydrolase
TL08_18315	COG1929	Belongs to the glycerate kinase type-1 family
TL08_18330	COG2205	protein histidine kinase activity
TL08_18355	COG3321	synthase
TL08_18355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TL08_18380	COG4221	oxidoreductase activity
TL08_18390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TL08_18450	COG2072	flavoprotein involved in K transport
TL08_18455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TL08_18460	COG2197	response regulator
TL08_18465	COG4585	Histidine kinase
TL08_18475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TL08_18480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TL08_18525	COG0142	geranyltranstransferase activity
TL08_18545	COG1414	Transcriptional regulator
TL08_18555	COG2124	cytochrome p450
TL08_18720	COG0129	dihydroxy-acid dehydratase activity
TL08_18730	COG2318	DinB family
TL08_18740	COG4977	sequence-specific DNA binding
TL08_18740	COG1917	Cupin 2, conserved barrel domain protein
TL08_18800	COG1064	alcohol dehydrogenase
TL08_18805	COG1309	transcriptional regulator
TL08_18845	COG0439	Biotin carboxylase
TL08_18900	COG1120	ATPase activity
TL08_18945	COG0515	serine threonine protein kinase
TL08_18960	COG2197	response regulator
TL08_18965	COG4585	Histidine kinase
TL08_18975	COG0577	efflux transmembrane transporter activity
TL08_18975	COG1136	(ABC) transporter
TL08_18990	COG0579	oxidoreductase
TL08_19025	COG0714	Associated with various cellular activities
TL08_19030	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TL08_19065	COG3467	pyridoxamine 5'-phosphate
TL08_19080	COG0803	Belongs to the bacterial solute-binding protein 9 family
TL08_19090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TL08_19120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_19165	COG0583	DNA-binding transcription factor activity
TL08_19170	COG2851	Citrate transporter
TL08_19275	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_19290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TL08_19310	COG1349	DNA-binding transcription factor activity
TL08_19315	COG2264	protein methyltransferase activity
TL08_19320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_19320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_19325	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_19330	COG1404	Belongs to the peptidase S8 family
TL08_19335	COG1404	Belongs to the peptidase S8 family
TL08_19375	COG1175	transmembrane transport
TL08_19380	COG0395	ABC-type sugar transport system, permease component
TL08_19400	COG2357	RelA SpoT domain protein
TL08_19415	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_19425	COG2124	cytochrome p450
TL08_19440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TL08_19445	COG2315	Protein conserved in bacteria
TL08_19465	COG0747	negative chemotaxis
TL08_19495	COG1414	Transcriptional regulator
TL08_19505	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_19515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TL08_19525	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_19545	COG0297	glycogen (starch) synthase activity
TL08_19565	COG2192	nodulation
TL08_19570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TL08_19575	COG0859	PFAM glycosyl transferase family 9
TL08_19580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TL08_19585	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TL08_19585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TL08_19600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TL08_19610	COG0587	DNA-directed DNA polymerase activity
TL08_19645	COG2132	Multicopper oxidase
TL08_19650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TL08_19660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TL08_19665	COG0583	DNA-binding transcription factor activity
TL08_19670	COG4166	transmembrane transport
TL08_19675	COG0601	transmembrane transport
TL08_19685	COG0444	Belongs to the ABC transporter superfamily
TL08_19690	COG4608	Belongs to the ABC transporter superfamily
TL08_19705	COG0640	Transcriptional regulator
TL08_19725	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_19730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TL08_19735	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_19740	COG1414	Transcriptional regulator
TL08_19760	COG0583	DNA-binding transcription factor activity
TL08_19765	COG2814	Major facilitator Superfamily
TL08_19775	COG0667	Aldo Keto reductase
TL08_19835	COG1280	lysine exporter protein (LysE YggA)
TL08_19875	COG0477	Major facilitator Superfamily
TL08_19880	COG0477	Major facilitator Superfamily
TL08_19910	COG2390	Transcriptional regulator
TL08_19915	COG1063	alcohol dehydrogenase
TL08_19930	COG0395	ABC-type sugar transport system, permease component
TL08_19935	COG1309	transcriptional regulator
TL08_19955	COG0243	molybdopterin cofactor binding
TL08_19975	COG0667	Aldo Keto reductase
TL08_19980	COG5000	phosphorelay sensor kinase activity
TL08_19985	COG0590	tRNA wobble adenosine to inosine editing
TL08_19985	COG0037	tRNA processing
TL08_20000	COG2124	cytochrome p450
TL08_20005	COG2124	cytochrome p450
TL08_20010	COG0697	spore germination
TL08_20015	COG3903	Transcriptional regulator
TL08_20015	COG3629	intracellular signal transduction
TL08_20055	COG1857	crispr-associated protein
TL08_20090	COG3401	FG-GAP repeat protein
TL08_20095	COG1309	transcriptional regulator
TL08_20135	COG1857	crispr-associated protein
TL08_20170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TL08_20180	COG2183	response to ionizing radiation
TL08_20195	COG4585	Histidine kinase
TL08_20200	COG2197	response regulator
TL08_20205	COG1271	oxidase subunit
TL08_20215	COG4988	ABC transporter
TL08_20220	COG1132	(ABC) transporter
TL08_20255	COG1120	ATPase activity
TL08_20260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_20310	COG1366	Belongs to the anti-sigma-factor antagonist family
TL08_20345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TL08_20355	COG0693	protein deglycase activity
TL08_20390	COG0248	Ppx GppA phosphatase
TL08_20395	COG3842	ATPase activity
TL08_20400	COG1609	Transcriptional regulator
TL08_20415	COG1609	Transcriptional regulator
TL08_20445	COG2755	lipolytic protein G-D-S-L family
TL08_20450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TL08_20460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_20460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TL08_20465	COG1302	Protein conserved in bacteria
TL08_20495	COG1793	dna ligase
TL08_20505	COG0124	histidyl-tRNA synthetase
TL08_20515	COG1320	monovalent cation:proton antiporter activity
TL08_20535	COG1006	Multisubunit Na H antiporter MnhC subunit
TL08_20540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TL08_20540	COG2111	Na H antiporter
TL08_20560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TL08_20580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TL08_20590	COG2197	response regulator
TL08_20620	COG0183	Belongs to the thiolase family
TL08_20625	COG1250	3-hydroxyacyl-CoA dehydrogenase
TL08_20625	COG1024	Enoyl-CoA hydratase
TL08_20640	COG4948	Mandelate Racemase Muconate Lactonizing
TL08_20645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TL08_20650	COG0673	inositol 2-dehydrogenase activity
TL08_20655	COG1653	transport
TL08_20660	COG1175	transmembrane transport
TL08_20665	COG0395	ABC-type sugar transport system, permease component
TL08_20690	COG3866	Pectate lyase
TL08_20695	COG3866	Pectate lyase
TL08_20700	COG3507	Belongs to the glycosyl hydrolase 43 family
TL08_20725	COG1070	Carbohydrate kinase
TL08_20735	COG3347	Dehydrogenase
TL08_20735	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_20740	COG4952	isomerase
TL08_20745	COG3254	rhamnose metabolic process
TL08_20780	COG0673	inositol 2-dehydrogenase activity
TL08_20795	COG5297	Belongs to the glycosyl hydrolase family 6
TL08_20830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TL08_20830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TL08_20850	COG0823	Involved in the tonB-independent uptake of proteins
TL08_20850	COG1506	peptidase
TL08_20910	COG2197	response regulator
TL08_20950	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TL08_20990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TL08_21010	COG1309	transcriptional regulator
TL08_21045	COG0494	nUDIX hydrolase
TL08_21060	COG5001	Diguanylate cyclase
TL08_21120	COG2197	response regulator
TL08_21125	COG4585	Histidine kinase
TL08_21160	COG2311	Membrane
TL08_21175	COG2197	response regulator
TL08_21180	COG4585	Histidine kinase
TL08_21190	COG1131	(ABC) transporter
TL08_21200	COG0596	Alpha beta hydrolase
TL08_21210	COG1902	pentaerythritol trinitrate reductase activity
TL08_21225	COG4106	trans-aconitate 2-methyltransferase activity
TL08_21235	COG0358	DNA primase activity
TL08_21240	COG1595	DNA-templated transcription, initiation
TL08_21250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TL08_21260	COG3340	Belongs to the peptidase S51 family
TL08_21265	COG0423	glycine-tRNA ligase activity
TL08_21300	COG0701	Predicted permease
TL08_21310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TL08_21335	COG1131	(ABC) transporter
TL08_21345	COG1381	Involved in DNA repair and RecF pathway recombination
TL08_21360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TL08_21380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TL08_21390	COG0537	adenosine 5'-monophosphoramidase activity
TL08_21400	COG0484	heat shock protein binding
TL08_21405	COG1420	regulation of RNA biosynthetic process
TL08_21445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TL08_21450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_21480	COG0604	alcohol dehydrogenase
TL08_21510	COG0443	Heat shock 70 kDa protein
TL08_21515	COG1201	RNA secondary structure unwinding
TL08_21570	COG2815	serine threonine protein kinase
TL08_21570	COG0515	serine threonine protein kinase
TL08_21580	COG2268	Band 7 protein
TL08_21600	COG0584	glycerophosphoryl diester phosphodiesterase
TL08_21610	COG0583	DNA-binding transcription factor activity
TL08_21625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TL08_21630	COG3209	COG3209 Rhs family protein
TL08_21640	COG3209	COG3209 Rhs family protein
TL08_21680	COG1940	carbohydrate kinase activity
TL08_21690	COG0003	Pfam Anion-transporting ATPase
TL08_21715	COG0438	transferase activity, transferring glycosyl groups
TL08_21755	COG2010	Cytochrome c
TL08_21760	COG1845	cytochrome c oxidase, subunit III
TL08_21775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TL08_21785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TL08_21815	COG0667	Aldo Keto reductase
TL08_21830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TL08_21835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TL08_21840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TL08_21855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TL08_21865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TL08_21880	COG0321	lipoyl(octanoyl) transferase activity
TL08_21890	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_21895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TL08_21915	COG0174	glutamine synthetase
TL08_21925	COG1733	regulation of RNA biosynthetic process
TL08_21945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TL08_21980	COG0174	glutamine synthetase
TL08_21990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TL08_21990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TL08_21995	COG2318	DinB family
TL08_22000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TL08_22005	COG0435	Glutathione S-transferase
TL08_22080	COG0406	alpha-ribazole phosphatase activity
TL08_22080	COG0328	RNA-DNA hybrid ribonuclease activity
TL08_22135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TL08_22155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TL08_22175	COG2239	Acts as a magnesium transporter
TL08_22190	COG3201	nicotinamide mononucleotide transporter
TL08_22195	COG0668	transmembrane transport
TL08_22210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TL08_22215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TL08_22290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TL08_22330	COG1254	Belongs to the acylphosphatase family
TL08_22335	COG2340	Cysteine-rich secretory protein family
TL08_22355	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TL08_22365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TL08_22380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TL08_22385	COG0571	ribonuclease III activity
TL08_22390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TL08_22410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TL08_22415	COG0742	ribosomal rna small subunit methyltransferase
TL08_22425	COG1846	Transcriptional regulator
TL08_22430	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TL08_22480	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TL08_22485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TL08_22500	COG3976	FMN-binding domain protein
TL08_22500	COG1053	succinate dehydrogenase
TL08_22500	COG0431	NADPH-dependent FMN reductase
TL08_22520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TL08_22525	COG1461	Dihydroxyacetone kinase
TL08_22530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TL08_22535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TL08_22545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TL08_22570	COG1725	Transcriptional regulator
TL08_22575	COG1131	(ABC) transporter
TL08_22595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_22610	COG0626	cystathionine gamma-synthase activity
TL08_22615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TL08_22645	COG0066	3-isopropylmalate dehydratase activity
TL08_22650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TL08_22670	COG1011	Hydrolase
TL08_22675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TL08_22685	COG0179	Fumarylacetoacetate (FAA) hydrolase
TL08_22690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TL08_22700	COG0473	3-isopropylmalate dehydrogenase activity
TL08_22705	COG1404	Belongs to the peptidase S8 family
TL08_22725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TL08_22730	COG0440	acetolactate synthase activity
TL08_22745	COG0129	dihydroxy-acid dehydratase activity
TL08_22765	COG0515	serine threonine protein kinase
TL08_22765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TL08_22785	COG2259	Doxx family
TL08_22805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TL08_22820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TL08_22825	COG0154	amidase activity
TL08_22830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TL08_22845	COG1214	PFAM Peptidase M22, glycoprotease
TL08_22845	COG0456	acetyltransferase
TL08_22850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TL08_22855	COG1253	flavin adenine dinucleotide binding
TL08_22870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TL08_22875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TL08_22895	COG0596	Alpha beta hydrolase
TL08_22895	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_22915	COG1960	acyl-CoA dehydrogenase activity
TL08_22925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TL08_22930	COG1309	transcriptional regulator
TL08_22965	COG2149	membrane
TL08_22975	COG2508	Transcriptional regulator
TL08_22975	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TL08_22980	COG0686	Belongs to the AlaDH PNT family
TL08_23005	COG1132	(ABC) transporter
TL08_23010	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_23010	COG0567	Dehydrogenase, E1 component
TL08_23040	COG1228	amidohydrolase
TL08_23075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TL08_23080	COG2986	histidine ammonia-lyase
TL08_23105	COG1174	glycine betaine transport
TL08_23110	COG1174	glycine betaine transport
TL08_23115	COG1125	glycine betaine transport
TL08_23115	COG0517	IMP dehydrogenase activity
TL08_23145	COG0406	alpha-ribazole phosphatase activity
TL08_23165	COG1597	lipid kinase activity
TL08_23180	COG5662	AntiSigma factor
TL08_23200	COG2135	peptidase activity
TL08_23205	COG2135	peptidase activity
TL08_23210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TL08_23215	COG1162	GTPase activity
TL08_23230	COG1012	belongs to the aldehyde dehydrogenase family
TL08_23245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_23260	COG0653	protein targeting
TL08_23265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TL08_23290	COG5000	phosphorelay sensor kinase activity
TL08_23290	COG5002	protein histidine kinase activity
TL08_23295	COG0745	RESPONSE REGULATOR receiver
TL08_23335	COG0531	amino acid
TL08_23340	COG1482	cell wall glycoprotein biosynthetic process
TL08_23350	COG2835	tetraacyldisaccharide 4'-kinase activity
TL08_23385	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TL08_23385	COG0778	Nitroreductase
TL08_23425	COG0438	transferase activity, transferring glycosyl groups
TL08_23440	COG1316	TRANSCRIPTIONal
TL08_23445	COG1316	TRANSCRIPTIONal
TL08_23470	COG1131	(ABC) transporter
TL08_23495	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_23500	COG1129	ABC transporter
TL08_23515	COG1690	Belongs to the RtcB family
TL08_23520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TL08_23550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TL08_23555	COG2205	protein histidine kinase activity
TL08_23560	COG0745	RESPONSE REGULATOR receiver
TL08_23565	COG0483	inositol monophosphate 1-phosphatase activity
TL08_23620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TL08_23645	COG0739	heme binding
TL08_23650	COG2936	dipeptidyl-peptidase activity
TL08_23705	COG1840	ABC-type Fe3 transport system, periplasmic component
TL08_23715	COG3842	ATPase activity
TL08_23720	COG2828	Protein conserved in bacteria
TL08_23725	COG0583	DNA-binding transcription factor activity
TL08_23745	COG4770	biotin carboxylase activity
TL08_23785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TL08_23790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TL08_23795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TL08_23820	COG1473	amidohydrolase
TL08_23820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TL08_23855	COG0084	hydrolase, TatD family'
TL08_23870	COG0109	protoheme IX farnesyltransferase activity
TL08_23895	COG1879	ABC-type sugar transport system periplasmic component
TL08_23900	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_23905	COG1129	ABC transporter
TL08_23915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_23935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TL08_23945	COG4585	Histidine kinase
TL08_23950	COG1131	(ABC) transporter
TL08_23960	COG1940	carbohydrate kinase activity
TL08_23965	COG1070	Carbohydrate kinase
TL08_23985	COG1320	monovalent cation:proton antiporter activity
TL08_24020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_24020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_24025	COG0515	serine threonine protein kinase
TL08_24035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TL08_24040	COG0667	Aldo Keto reductase
TL08_24060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TL08_24070	COG4585	Histidine kinase
TL08_24075	COG2197	response regulator
TL08_24085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TL08_24090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TL08_24105	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_24125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TL08_24140	COG3629	intracellular signal transduction
TL08_24145	COG2030	dehydratase
TL08_24160	COG2409	Drug exporters of the RND superfamily
TL08_24180	COG2409	Drug exporters of the RND superfamily
TL08_24250	COG0604	alcohol dehydrogenase
TL08_24260	COG1309	transcriptional regulator
TL08_24295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TL08_24300	COG1012	belongs to the aldehyde dehydrogenase family
TL08_24305	COG1012	belongs to the aldehyde dehydrogenase family
TL08_24335	COG1131	(ABC) transporter
TL08_24345	COG1595	DNA-templated transcription, initiation
TL08_24360	COG1131	(ABC) transporter
TL08_24385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TL08_24420	COG1744	ABC transporter substrate-binding protein PnrA-like
TL08_24425	COG2009	succinate dehydrogenase
TL08_24440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TL08_24445	COG1686	Belongs to the peptidase S11 family
TL08_24450	COG1295	ribonuclease BN
TL08_24465	COG0708	Exodeoxyribonuclease III
TL08_24505	COG0039	L-malate dehydrogenase activity
TL08_24520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TL08_24550	COG0587	DNA-directed DNA polymerase activity
TL08_24595	COG0045	succinate-CoA ligase (ADP-forming) activity
TL08_24600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TL08_24610	COG0739	heme binding
TL08_24615	COG0739	heme binding
TL08_24655	COG0586	Pfam SNARE associated Golgi protein
TL08_24690	COG0583	DNA-binding transcription factor activity
TL08_24740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TL08_24740	COG0519	Catalyzes the synthesis of GMP from XMP
TL08_24745	COG1012	belongs to the aldehyde dehydrogenase family
TL08_24755	COG0697	spore germination
TL08_24765	COG0516	GMP reductase activity
TL08_24805	COG0459	protein refolding
TL08_24810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TL08_24815	COG3540	Alkaline phosphatase
TL08_24820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TL08_24825	COG0456	acetyltransferase
TL08_24845	COG0802	atpase or kinase
TL08_24865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TL08_24915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TL08_24920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TL08_24925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TL08_24950	COG1674	ftsk spoiiie
TL08_24960	COG1404	Belongs to the peptidase S8 family
TL08_25060	COG1674	ftsk spoiiie
TL08_25070	COG0456	acetyltransferase
TL08_25075	COG2130	NADP-dependent
TL08_25080	COG3800	Transcriptional regulator
TL08_25080	COG1396	sequence-specific DNA binding
TL08_25090	COG4152	abc transporter atp-binding protein
TL08_25095	COG1668	transmembrane transport
TL08_25100	COG0415	Belongs to the DNA photolyase family
TL08_25115	COG1228	amidohydrolase
TL08_25120	COG2017	converts alpha-aldose to the beta-anomer
TL08_25125	COG0531	amino acid
TL08_25130	COG0477	Major facilitator Superfamily
TL08_25135	COG0259	pyridoxamine-phosphate oxidase activity
TL08_25165	COG1132	(ABC) transporter
TL08_25170	COG1132	(ABC) transporter
TL08_25180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_25190	COG2814	Major facilitator Superfamily
TL08_25200	COG2252	PERMEase
TL08_25225	COG2814	Major facilitator Superfamily
TL08_25235	COG1278	Cold shock
TL08_25250	COG0384	phenazine biosynthesis protein PhzF
TL08_25265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TL08_25275	COG1652	LysM domain
TL08_25315	COG2018	Roadblock/LC7 domain
TL08_25340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TL08_25345	COG1116	anion transmembrane transporter activity
TL08_25350	COG1061	Type III restriction enzyme res subunit
TL08_25410	COG0459	protein refolding
TL08_25435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TL08_25440	COG0667	Aldo Keto reductase
TL08_25450	COG0167	dihydroorotate dehydrogenase activity
TL08_25495	COG2733	membrane
TL08_25520	COG1404	Belongs to the peptidase S8 family
TL08_25545	COG3973	AAA domain
TL08_25565	COG1733	regulation of RNA biosynthetic process
TL08_25575	COG2169	Transcriptional regulator
TL08_25575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TL08_25585	COG0519	Catalyzes the synthesis of GMP from XMP
TL08_25595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_25600	COG2364	Membrane
TL08_25610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TL08_25635	COG0463	Glycosyl transferase, family 2
TL08_25655	COG1216	Glycosyl transferase, family 2
TL08_25720	COG1316	TRANSCRIPTIONal
TL08_25740	COG1960	acyl-CoA dehydrogenase activity
TL08_25745	COG1522	sequence-specific DNA binding
TL08_25830	COG1414	Transcriptional regulator
TL08_25835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TL08_25840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TL08_25860	COG3706	GGDEF domain
TL08_25860	COG0745	RESPONSE REGULATOR receiver
TL08_25875	COG0704	Plays a role in the regulation of phosphate uptake
TL08_25885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TL08_25890	COG0581	inorganic phosphate transmembrane transporter activity
TL08_25905	COG0456	acetyltransferase
TL08_25910	COG0745	RESPONSE REGULATOR receiver
TL08_25945	COG4044	May play a role in the intracellular transport of hydrophobic ligands
TL08_26010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TL08_26025	COG3387	PFAM Glycoside hydrolase 15-related
TL08_26050	COG0047	phosphoribosylformylglycinamidine synthase activity
TL08_26055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TL08_26060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TL08_26080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TL08_26090	COG1595	DNA-templated transcription, initiation
TL08_26095	COG0789	Transcriptional regulator
TL08_26110	COG2076	Multidrug Resistance protein
TL08_26120	COG1595	DNA-templated transcription, initiation
TL08_26140	COG0436	Aminotransferase
TL08_26160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TL08_26180	COG4129	membrane
TL08_26235	COG0277	FAD linked oxidase domain protein
TL08_26245	COG2197	response regulator
TL08_26260	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TL08_26270	COG0443	Heat shock 70 kDa protein
TL08_26320	COG1115	amino acid carrier protein
TL08_26325	COG0471	metal ion transport
TL08_26330	COG0542	response to heat
TL08_26355	COG0596	Alpha beta hydrolase
TL08_26380	COG1704	LemA family
TL08_26385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TL08_26405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TL08_26415	COG0789	Transcriptional regulator
TL08_26420	COG0484	heat shock protein binding
TL08_26425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TL08_26430	COG0443	Heat shock 70 kDa protein
TL08_26440	COG0247	lactate metabolic process
TL08_26440	COG2181	nitrate reductase activity
TL08_26445	COG1051	belongs to the nudix hydrolase family
TL08_26470	COG0686	Belongs to the AlaDH PNT family
TL08_26490	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TL08_26535	COG1120	ATPase activity
TL08_26540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TL08_26555	COG5398	heme oxygenase
TL08_26565	COG1028	Short-chain dehydrogenase reductase Sdr
TL08_26590	COG0546	phosphoglycolate phosphatase activity
TL08_26605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TL08_26615	COG0477	Major facilitator Superfamily
TL08_26630	COG0583	DNA-binding transcription factor activity
TL08_26635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TL08_26640	COG1960	acyl-CoA dehydrogenase activity
TL08_26665	COG1309	transcriptional regulator
TL08_26675	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TL08_26710	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TL08_26720	COG1126	abc transporter atp-binding protein
TL08_26725	COG0765	amino acid transport
TL08_26730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TL08_26740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TL08_26750	COG0022	dehydrogenase e1 component
TL08_26755	COG0508	dehydrogenase complex catalyzes the overall conversion of
TL08_26780	COG0300	oxidoreductase activity
TL08_26790	COG3339	Conserved Protein
TL08_26795	COG1260	myo-inositol-1-phosphate synthase
TL08_26815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TL08_26840	COG0360	Binds together with S18 to 16S ribosomal RNA
TL08_26845	COG0629	single-stranded DNA binding
TL08_26850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TL08_26855	COG0359	binds to the 23S rRNA
TL08_26865	COG0305	Participates in initiation and elongation during chromosome replication
TL08_26900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TL08_26935	COG0745	RESPONSE REGULATOR receiver
TL08_26935	COG3706	GGDEF domain
TL08_26955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TL08_26960	COG1869	D-ribose catabolic process
TL08_26965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TL08_26970	COG1879	ABC-type sugar transport system periplasmic component
TL08_26975	COG1172	Belongs to the binding-protein-dependent transport system permease family
TL08_26980	COG1129	ABC transporter
TL08_26985	COG1609	Transcriptional regulator
TL08_27005	COG0495	leucyl-tRNA aminoacylation
TL08_27035	COG1678	Uncharacterized ACR, COG1678
TL08_27050	COG0617	tRNA 3'-terminal CCA addition
TL08_27070	COG0515	serine threonine protein kinase
TL08_27070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TL08_27095	COG3409	Peptidoglycan-binding domain 1 protein
TL08_27095	COG0860	N-Acetylmuramoyl-L-alanine amidase
TL08_27105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TL08_27110	COG1181	Belongs to the D-alanine--D-alanine ligase family
TL08_27120	COG1192	Involved in chromosome partitioning
TL08_27125	COG0357	Ribosomal RNA small subunit methyltransferase G
TL08_27130	COG1072	(Pantothenic acid kinase))
TL08_27145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TL08_27150	COG0594	ribonuclease P activity
TL08_27155	COG0230	Belongs to the bacterial ribosomal protein bL34 family