locus-tag class description UA74_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) UA74_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) UA74_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase UA74_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA74_00025 ENOG4105K7N UPF0232 protein UA74_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) UA74_00070 ENOG4105DHF Membrane UA74_00095 ENOG4105XBB septation inhibitor protein UA74_00105 ENOG4108U4N (sortase) family UA74_00135 ENOG4107TPY serine threonine protein kinase UA74_00140 ENOG4105CJN penicillin-binding protein UA74_00155 ENOG4105HZM Fha domain containing protein UA74_00160 ENOG4105TV9 FHA Domain-Containing protein UA74_00170 ENOG4105C75 arginyL-tRNA synthetase UA74_00195 ENOG4108SGK Tetr family transcriptional regulator UA74_00230 ENOG4108T5E Copper resistance protein UA74_00245 ENOG4105C94 Transporter UA74_00250 ENOG4105E90 ABC transporter UA74_00255 ENOG4108IJ8 ABC transporter UA74_00260 ENOG4105E90 ABC transporter UA74_00265 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system UA74_00285 ENOG4107SET aldo keto reductase UA74_00335 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) UA74_00340 ENOG4105KRQ Addiction module toxin, Txe YoeB family UA74_00345 ENOG4105VTW prevent-host-death family UA74_00415 ENOG4107QN1 sodium solute UA74_00435 ENOG4105DY9 regulatoR UA74_00445 ENOG4108HRK Histidine kinase UA74_00465 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving UA74_00500 ENOG4107YEV ferritin UA74_00505 ENOG4105CEU Arginine dihydrolase UA74_00550 ENOG4105C4M (Ubiquinol oxidase) subunit I UA74_00555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii UA74_00560 ENOG4108JJ9 ABC, transporter UA74_00580 ENOG4108UVJ appr-1-p processing domain protein UA74_00610 ENOG4106032 Glutathionylspermidine synthase UA74_00615 ENOG4105P3N Membrane UA74_00640 ENOG410667J hydrolase UA74_00645 ENOG4105C1B dTDP-glucose 4-6-dehydratase UA74_00675 ENOG4105D5U fad dependent oxidoreductase UA74_00685 ENOG410602S Transferase UA74_00695 ENOG4108MKI Glycosyl transferase, family 2 UA74_00725 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein UA74_00735 ENOG4105IIU Aminopeptidase UA74_00800 ENOG4105CIH Imidazole acetol-phosphate transaminase UA74_00805 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) UA74_00810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) UA74_00840 ENOG4105CHU acetyl-coa acetyltransferase UA74_00850 ENOG4105EVN Prephenate dehydrogenase UA74_00860 ENOG4108Z6B deaminase UA74_00885 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) UA74_00910 ENOG410804X Transcriptional regulator UA74_00915 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) UA74_00925 ENOG4107QSI ABC, transporter UA74_00930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA74_00935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_00950 ENOG4105CPC Aldo Keto reductase UA74_00955 ENOG4105CNV Aldolase UA74_00965 ENOG4108JQ1 Dehydrogenase UA74_00970 ENOG4105CXK mandelate racemase muconate lactonizing UA74_00975 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) UA74_00995 ENOG4105CNN ABC, transporter UA74_01000 ENOG4105C2J ABC transporter UA74_01005 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator UA74_01030 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) UA74_01040 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein UA74_01045 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA74_01050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_01055 ENOG4105C3U ABC transporter UA74_01060 ENOG4108JQ7 (ABC) transporter UA74_01090 ENOG4105CFH Aspartokinase UA74_01105 ENOG4105CH6 catalase UA74_01120 ENOG4108ZHJ Organic hydroperoxide resistance protein UA74_01130 ENOG4106UDK Cellulose-binding, family II UA74_01145 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases UA74_01160 ENOG4105DIN metallophosphoesterase UA74_01175 ENOG4105BZ4 penicillin-binding protein UA74_01240 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) UA74_01280 ENOG4105D74 hydrolase UA74_01295 ENOG4105HF0 Membrane UA74_01320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) UA74_01325 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) UA74_01335 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate UA74_01340 ENOG4106KNT transcriptional regulator UA74_01365 ENOG4105FQP Beta-lactamase UA74_01370 ENOG4105EHZ conserved protein UCP016719 UA74_01375 ENOG4105D17 glycoside hydrolase, family 3 domain protein UA74_01430 ENOG4108I5C dEAD DEAH box helicase UA74_01435 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for UA74_01445 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) UA74_01455 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) UA74_01460 ENOG4107QRG dna polymerase iii UA74_01470 ENOG41068WN UA74_01480 ENOG4105C0B DNA polymerase III (alpha subunit) UA74_01485 ENOG4105EEM helicase UA74_01505 ENOG4105F0N pyrophosphate phospho-hydrolase UA74_01535 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) UA74_01545 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) UA74_01550 ENOG4105EUJ GTP cyclohydrolase i UA74_01595 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) UA74_01600 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) UA74_01605 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) UA74_01610 ENOG4105CRK lysyL-tRNA synthetase UA74_01625 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit UA74_01635 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) UA74_01650 ENOG4105CEN a g-specific adenine glycosylase UA74_01655 ENOG4106T9R serine protease UA74_01660 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) UA74_01670 ENOG4108VJ1 Transcriptional regulator (CarD family UA74_01675 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) UA74_01680 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) UA74_01690 ENOG4105C8N cysteinyl-tRNA synthetase UA74_01695 ENOG4105C2N RNA methyltransferase TrmH family group 3 UA74_01700 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein UA74_01740 ENOG4105ECY inositol monophosphatase UA74_01745 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) UA74_01755 ENOG4105CC5 ABC transporter UA74_01760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UA74_01765 ENOG4105DSE periplasmic solute binding protein UA74_01775 ENOG4105EG2 ABC transporter, permease UA74_01780 ENOG4105D56 permease protein UA74_01805 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase UA74_01825 ENOG4105CPC Aldo Keto reductase UA74_01830 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase UA74_01835 ENOG4108JPW Aminotransferase UA74_01840 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) UA74_01845 ENOG4105EV8 ectoine hydroxylase UA74_01850 ENOG41065RQ ADP-ribosylation crystallin J1 UA74_01850 ENOG41065RQ ADP-ribosylation crystallin J1 UA74_01875 ENOG41073TP transcriptional regulator UA74_01890 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UA74_01895 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) UA74_01900 ENOG4105DWF phosphomethylpyrimidine kinase UA74_01915 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) UA74_01925 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) UA74_01930 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) UA74_01940 ENOG4105D9U N-acetyltransferase UA74_01950 ENOG4106T9R serine protease UA74_01955 ENOG4106T9R serine protease UA74_01960 ENOG4106T9R serine protease UA74_01965 ENOG4106T9R serine protease UA74_01970 ENOG4105FDP GntR family transcriptional regulator UA74_01980 ENOG4105D56 permease protein UA74_01985 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component UA74_01990 ENOG4105D17 glycoside hydrolase, family 3 domain protein UA74_01995 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) UA74_02005 ENOG4105BZU Histidine kinase UA74_02010 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_02020 ENOG41084I6 Protein CrcB homolog UA74_02025 ENOG41082CG Protein CrcB homolog UA74_02035 ENOG4105V9F hemagglutinin UA74_02040 ENOG4105TT9 Protein of unknown function (DUF2516) UA74_02105 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase UA74_02155 ENOG4105XEA Tetr family transcriptional regulator UA74_02175 ENOG4107R4N Cell wall formation (By similarity) UA74_02210 ENOG4105C57 major facilitator superfamily UA74_02220 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA74_02230 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) UA74_02235 ENOG4105BZU Histidine kinase UA74_02260 ENOG4105II7 pyrroline-5-carboxylate reductase UA74_02285 ENOG4108RXW HAD-superfamily subfamily IB hydrolase UA74_02295 ENOG4105C1G acyl-Coa dehydrogenase UA74_02315 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) UA74_02320 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) UA74_02330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) UA74_02335 ENOG4105D52 delta-aminolevulinic acid dehydratase UA74_02370 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase UA74_02375 ENOG4108RH7 phosphoglycerate mutase UA74_02390 ENOG4108762 serine threonine protein kinase UA74_02395 ENOG4107QIV Cytochrome c biogenesis protein UA74_02405 ENOG4105CRE cytochrome C UA74_02490 ENOG4108IPT Naphthoate synthase UA74_02495 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) UA74_02500 ENOG4105E4F Isochorismate synthase UA74_02515 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit UA74_02520 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit UA74_02525 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit UA74_02530 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit UA74_02535 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) UA74_02550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA74_02565 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA74_02570 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain UA74_02575 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA74_02585 ENOG4107QIZ NADH dehydrogenase UA74_02590 ENOG4108IEH NADH dehydrogenase subunit g UA74_02595 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) UA74_02600 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA74_02605 ENOG41087XN oxidoreductase UA74_02610 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA74_02625 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA74_02645 ENOG4105DQU oxidoreductase, subunit beta UA74_02650 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein UA74_02655 ENOG4105F7P transcriptional regulator AsnC family UA74_02660 ENOG4105CIK Amidinotransferase UA74_02665 ENOG4106F60 Histidine kinase UA74_02670 ENOG4105F44 Two component transcriptional regulator, winged helix family UA74_02685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA74_02690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA74_02700 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) UA74_02745 ENOG4105D0M Protease HtpX homolog UA74_02750 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) UA74_02765 ENOG4107S9F NmrA family UA74_02785 ENOG4108VPT UPF0234 protein UA74_02790 ENOG4105BZU Histidine kinase UA74_02805 ENOG4105WDJ 50S ribosomal protein L33 UA74_02810 ENOG410900P UPF0336 protein UA74_02840 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) UA74_02850 ENOG4108VZM 50s ribosomal protein L10 UA74_02855 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) UA74_02860 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UA74_02865 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UA74_02920 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) UA74_02925 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) UA74_02930 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) UA74_02935 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) UA74_02945 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) UA74_02950 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) UA74_02955 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) UA74_02960 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity UA74_02965 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) UA74_02970 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) UA74_02975 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) UA74_02980 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) UA74_02985 ENOG41082SA 50s ribosomal protein l29 UA74_02990 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal UA74_02995 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) UA74_03000 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) UA74_03005 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits UA74_03010 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) UA74_03015 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) UA74_03020 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) UA74_03025 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) UA74_03030 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) UA74_03035 ENOG410849U 50S ribosomal protein L30 UA74_03040 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) UA74_03100 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) UA74_03125 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits UA74_03130 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) UA74_03135 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) UA74_03140 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UA74_03145 ENOG4108ZT0 50S ribosomal protein l17 UA74_03150 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) UA74_03170 ENOG4105BZU Histidine kinase UA74_03185 ENOG4105HNP -acetyltransferase UA74_03205 ENOG4105BZU Histidine kinase UA74_03215 ENOG4105EN6 Membrane UA74_03220 ENOG4105ETX regulatoR UA74_03225 ENOG41062D9 Histidine kinase UA74_03235 ENOG4105C0H protease UA74_03240 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) UA74_03255 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) UA74_03270 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase UA74_03275 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase UA74_03285 ENOG4105D9U N-acetyltransferase UA74_03325 ENOG4107QM2 Aldo Keto reductase UA74_03405 ENOG4105BZU Histidine kinase UA74_03430 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) UA74_03435 ENOG4105F8V Hydrolase, tatD family UA74_03440 ENOG4105MS9 Resuscitation-promoting factor UA74_03445 ENOG4108KE4 O-methyltransferase UA74_03460 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) UA74_03540 ENOG4108KPJ rna polymerase sigma factor UA74_03545 ENOG4105CEP NADH dehydrogenase UA74_03550 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) UA74_03555 ENOG4108UMI ABC transporter, permease UA74_03560 ENOG4105D01 (LipO)protein UA74_03570 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) UA74_03575 ENOG4107Y80 Major Facilitator superfamily UA74_03585 ENOG4105C5H ABC transporter UA74_03595 ENOG41061H0 Monooxygenase UA74_03615 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) UA74_03620 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) UA74_03635 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) UA74_03640 ENOG4105BZU Histidine kinase UA74_03655 ENOG41067SE Tetr family transcriptional regulator UA74_03690 ENOG4105C6Z Gluconate UA74_03695 ENOG4105C01 Dihydroxy-acid dehydratase UA74_03705 ENOG4107RE3 peptidase, S41 UA74_03730 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) UA74_03785 ENOG4105C7R Atpase associated with various cellular activities aaa_3 UA74_03800 ENOG4105CEP NADH dehydrogenase UA74_03840 ENOG4105CHU acetyl-coa acetyltransferase UA74_03865 ENOG4107HP6 Transcriptional regulator UA74_03870 ENOG4105E4C Lytic transglycosylase catalytic UA74_03890 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component UA74_03895 ENOG4105DRS transport system, permease UA74_03910 ENOG4105CXK mandelate racemase muconate lactonizing UA74_03975 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein UA74_03985 ENOG4105C7B Threonine dehydratase UA74_04005 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase UA74_04015 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) UA74_04025 ENOG4105T1M mycothiol conjugate amidase mca UA74_04035 ENOG4105DXX methyltransferase UA74_04040 ENOG4107S1Q Phosphatase UA74_04070 ENOG4105C7Z Conserved Protein UA74_04095 ENOG4108IAB Phoh family UA74_04105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA74_04115 ENOG4107VXM glycerophosphoryl diester phosphodiesterase UA74_04120 ENOG4105C9Q fumarate hydratase class II UA74_04125 ENOG4105CAY ferredoxin--nadp reductase UA74_04170 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) UA74_04180 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) UA74_04200 ENOG4105EYH Exonuclease UA74_04210 ENOG4105C3G gtp-binding protein UA74_04265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family UA74_04270 ENOG410842T Pterin carbinolamine dehydratase UA74_04280 ENOG4105E0C molybdate abc transporter UA74_04285 ENOG4108UCS ABC, transporter UA74_04335 ENOG4105CJ1 ABC, transporter UA74_04345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family UA74_04350 ENOG4105E0F Histidine kinase UA74_04380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_04390 ENOG4108JQ7 (ABC) transporter UA74_04395 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) UA74_04405 ENOG4108Z4U Ferredoxin UA74_04415 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) UA74_04430 ENOG4107R4C succinyl-diaminopimelate desuccinylase UA74_04450 ENOG4105CS1 NAD(P)H quinone oxidoreductase UA74_04455 ENOG4108URH decarboxylase UA74_04460 ENOG4105EEI dihydropteroate synthase UA74_04535 ENOG4108UKI Enoyl-CoA hydratase UA74_04540 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein UA74_04550 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) UA74_04555 ENOG4105DDW LysR family Transcriptional regulator UA74_04560 ENOG4105D94 Major Facilitator Superfamily UA74_04565 ENOG4107QPH glycogen) synthase UA74_04570 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) UA74_04575 ENOG4107ZBN O-methyltransferase UA74_04590 ENOG4105C0H protease UA74_04595 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) UA74_04610 ENOG4105CI0 Citrate lyase UA74_04660 ENOG4105D7N magnesium and cobalt transport protein CorA UA74_04680 ENOG4105DB7 PHP domain protein UA74_04705 ENOG4105C1J atp-dependent rna helicase UA74_04725 ENOG4106HB6 Alpha beta hydrolase UA74_04770 ENOG4105C4R Atp-dependent dna helicase UA74_04790 ENOG4107SVH Potassium channel protein UA74_04815 ENOG4105C1V Peptidase, M16 UA74_04840 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA74_04890 ENOG41063PX domain protein UA74_04900 ENOG4105DJZ UPF0182 protein UA74_04920 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) UA74_04925 ENOG4105CAK Cell division ATP-binding protein ftsE UA74_04930 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) UA74_04935 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) UA74_04960 ENOG41080HT Transcriptional regulator, arsr family UA74_04965 ENOG4107T5V SNARE associated Golgi UA74_04980 ENOG4105CGH 5'-nucleotidase UA74_04985 ENOG4105CQ7 ATP-dependent helicase UA74_04990 ENOG4107RGD Major Facilitator superfamily UA74_05030 ENOG4107J0C type IIi UA74_05035 ENOG4107QMH DNA methylase UA74_05070 ENOG4105K64 Glycosyl transferase, family 2 UA74_05090 ENOG4107TB6 phosphoglycerate mutase UA74_05120 ENOG4108RWN rrna methyltransferase UA74_05130 ENOG4105BZ1 (ABC) transporter UA74_05135 ENOG4108JJ8 (ABC) transporter UA74_05140 ENOG4105CEY Amp-dependent synthetase and ligase UA74_05170 ENOG4105CEY Amp-dependent synthetase and ligase UA74_05180 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) UA74_05205 ENOG4105CEY Amp-dependent synthetase and ligase UA74_05215 ENOG4105CEY Amp-dependent synthetase and ligase UA74_05230 ENOG4105C37 (CBS) domain UA74_05235 ENOG4108M15 ABC transporter UA74_05245 ENOG4105BZU Histidine kinase UA74_05250 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_05255 ENOG4105CHJ isochorismatase hydrolase UA74_05260 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_05280 ENOG4105KVH Transcriptional regulator UA74_05315 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA74_05320 ENOG4106JDR secreted UA74_05325 ENOG4105ENE Histidine kinase UA74_05330 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_05340 ENOG4105PDP Short chain dehydrogenase UA74_05420 ENOG4108M15 ABC transporter UA74_05440 ENOG4105C57 major facilitator superfamily UA74_05450 ENOG41060BG Tetr family transcriptional regulator UA74_05500 ENOG4108PSK reductase UA74_05515 ENOG4105E1F short-chain dehydrogenase reductase UA74_05525 ENOG4106NZI LysR family Transcriptional regulator UA74_05530 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA74_05540 ENOG4105DWT malate dehydrogenase (quinone) UA74_05545 ENOG4105DIA mandelate racemase muconate lactonizing UA74_05595 ENOG4105BZN citrate synthase UA74_05615 ENOG4105JN3 extra-cytoplasmic solute receptor family protein UA74_05620 ENOG4107258 Transcriptional regulator UA74_05625 ENOG4105JSC dimethylmenaquinone methyltransferase UA74_05630 ENOG4108JQ1 Dehydrogenase UA74_05635 ENOG4105D9P serine threonine protein kinase UA74_05665 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase UA74_05680 ENOG41087PP glycosyltransferase MGT family UA74_05710 ENOG4105CHR reductase UA74_05720 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) UA74_05725 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) UA74_05730 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) UA74_05745 ENOG4105D74 hydrolase UA74_05755 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) UA74_05780 ENOG4105CJ1 ABC, transporter UA74_05785 ENOG41090VJ ABC-2 type transporter UA74_05805 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_05865 ENOG4105VPX protein, conserved in bacteria UA74_05890 ENOG4108UW5 maltose o-acetyltransferase UA74_05900 ENOG4107T6F Xaa-Pro aminopeptidase UA74_06035 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily UA74_06040 ENOG4108K01 transcriptional regulator UA74_06065 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_06070 ENOG4105BZU Histidine kinase UA74_06085 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA74_06090 ENOG4107R34 abc transporter permease protein UA74_06105 ENOG4107YPT transcriptional regulator UA74_06155 ENOG4105EAC phosphoserine phosphatase UA74_06170 ENOG4107ZYJ bioY protein UA74_06175 ENOG4108RWI nicotinamidase UA74_06185 ENOG4105CB2 alcohol dehydrogenase UA74_06195 ENOG4107RKP Nicotinate phosphoribosyltransferase UA74_06200 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) UA74_06210 ENOG4105KXX peptidase s58 dmpa UA74_06240 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) UA74_06250 ENOG4105D7N magnesium and cobalt transport protein CorA UA74_06255 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) UA74_06260 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) UA74_06275 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) UA74_06280 ENOG4108D32 Methyltransferase UA74_06360 ENOG4105DKW ABC transporter UA74_06370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA74_06375 ENOG4105EVB acetyltransferase UA74_06400 ENOG4108KQJ Type 11 methyltransferase UA74_06410 ENOG410905P Pyridoxamine 5-phosphate UA74_06440 ENOG4105C10 Electron transfer flavoprotein UA74_06450 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) UA74_06515 ENOG4105H3G oxidoreductase UA74_06585 ENOG4105VQD rieske 2fe-2S domain-containing protein UA74_06590 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region UA74_06600 ENOG4105DVW rieske (2Fe-2S) UA74_06610 ENOG41065HY 1,4-beta-cellobiosidase UA74_06655 ENOG4106A3M Cytochrome p-450 UA74_06670 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) UA74_06685 ENOG4105CEY Amp-dependent synthetase and ligase UA74_06700 ENOG4107AQZ Membrane UA74_06715 ENOG4108594 Permease of the drug metabolite transporter UA74_06720 ENOG4105XYF acetyltransferase UA74_06775 ENOG4107WAU Protein tyrosine phosphatase UA74_06785 ENOG4105CIR epoxide hydrolase UA74_06810 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr UA74_06870 ENOG4108URH decarboxylase UA74_06875 ENOG4105C2C drug resistance transporter, Bcr CflA UA74_06910 ENOG4105D82 Glutamate dehydrogenase UA74_06915 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) UA74_06920 ENOG4105CPN adenine deaminase UA74_06930 ENOG4105PGM cation diffusion facilitator family transporter UA74_06935 ENOG4108KPJ rna polymerase sigma factor UA74_06960 ENOG4105C75 arginyL-tRNA synthetase UA74_06965 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) UA74_06970 ENOG4105D6E homoserine dehydrogenase UA74_06975 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) UA74_06980 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) UA74_06985 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) UA74_06985 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) UA74_06995 ENOG4105VFB Binds the 23S rRNA (By similarity) UA74_07000 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) UA74_07005 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) UA74_07020 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) UA74_07025 ENOG4105ESV Glycosyl transferase, family 4 UA74_07035 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) UA74_07045 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) UA74_07050 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) UA74_07055 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) UA74_07060 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) UA74_07065 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) UA74_07075 ENOG4105NAF rna polymerase sigma factor UA74_07080 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) UA74_07095 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) UA74_07100 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) UA74_07125 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA74_07130 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) UA74_07155 ENOG4105CMT Dihydroxyacetone kinase UA74_07165 ENOG4105VDH Dihydroxyacetone kinase UA74_07175 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 UA74_07185 ENOG4108ZVT methylmalonyl-coA epimerase UA74_07195 ENOG4105CHU acetyl-coa acetyltransferase UA74_07215 ENOG4105EYF MMPL domain protein UA74_07220 ENOG41067TZ transcriptional regulator, MarR family UA74_07230 ENOG4105D5P Methylmalonyl-coA mutase UA74_07255 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) UA74_07260 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) UA74_07275 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) UA74_07325 ENOG4105FKQ transcriptional regulator UA74_07345 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component UA74_07375 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_07390 ENOG4105MHT Transcriptional regulator, ARSR family UA74_07455 ENOG4105BZU Histidine kinase UA74_07460 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_07480 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) UA74_07495 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) UA74_07500 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) UA74_07505 ENOG4105CG3 alpha amylase, catalytic region UA74_07525 ENOG4105CPC Aldo Keto reductase UA74_07540 ENOG4105DTD Dehydrogenase UA74_07585 ENOG4107R7Y intracellular protease Pfpi family UA74_07610 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) UA74_07615 ENOG4105EBR Carboxylesterase UA74_07655 ENOG4105CIG ABC transporter UA74_07715 ENOG4105DEN Luciferase family UA74_07755 ENOG4105CYX Short-chain dehydrogenase reductase Sdr UA74_07770 ENOG4108KDT Molybdate metabolism regulator UA74_07785 ENOG4106F60 Histidine kinase UA74_07790 ENOG4105F44 Two component transcriptional regulator, winged helix family UA74_07795 ENOG4106JDR secreted UA74_07870 ENOG4105C7I Dehydrogenase UA74_07885 ENOG4105CG3 alpha amylase, catalytic region UA74_07895 ENOG4105D8X mechanosensitive ion channel UA74_07940 ENOG4109057 UA74_07950 ENOG4105MC2 DSBA oxidoreductase UA74_08020 ENOG4107QRI Phosphoketolase UA74_08035 ENOG4108RZE Tetr family transcriptional regulator UA74_08065 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation UA74_08070 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UA74_08075 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UA74_08080 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) UA74_08100 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) UA74_08125 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) UA74_08130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase UA74_08140 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) UA74_08150 ENOG4105HAC ABC-2 type transporter UA74_08155 ENOG4105HAC ABC-2 type transporter UA74_08165 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) UA74_08170 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA74_08180 ENOG4105C03 ribonuclease UA74_08180 ENOG4105C03 ribonuclease UA74_08205 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) UA74_08210 ENOG4105K46 50S ribosomal protein l27 UA74_08215 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control UA74_08220 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) UA74_08230 ENOG4105C9U ATP-dependent DNA helicase RecQ UA74_08235 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) UA74_08250 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) UA74_08255 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) UA74_08265 ENOG4108TZC UA74_08270 ENOG4105EPR degv family UA74_08275 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein UA74_08290 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) UA74_08300 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) UA74_08315 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) UA74_08355 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) UA74_08360 ENOG4105CEY Amp-dependent synthetase and ligase UA74_08375 ENOG4108RVA ribokinase UA74_08380 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) UA74_08410 ENOG4105C2J ABC transporter UA74_08415 ENOG4108HWW ABC transporter UA74_08420 ENOG4105E2R ROK family UA74_08430 ENOG4105CYX Short-chain dehydrogenase reductase Sdr UA74_08440 ENOG4105DFK Polyphosphate glucokinase UA74_08465 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) UA74_08490 ENOG4107VEG TrkA-N domain protein UA74_08495 ENOG4105C0X amino acid UA74_08500 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) UA74_08505 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) UA74_08510 ENOG4105F44 Two component transcriptional regulator, winged helix family UA74_08515 ENOG4106F60 Histidine kinase UA74_08530 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) UA74_08535 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) UA74_08540 ENOG4105KC9 Modulates RecA activity (By similarity) UA74_08550 ENOG4108UHU Aldolase UA74_08555 ENOG4105C01 Dihydroxy-acid dehydratase UA74_08570 ENOG4105DRP amino acid AbC transporter UA74_08575 ENOG4105E5Q amino acid AbC transporter UA74_08585 ENOG4105CDA abc transporter atp-binding protein UA74_08590 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) UA74_08600 ENOG4105C99 atpase involved in dna repair UA74_08610 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) UA74_08615 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) UA74_08625 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) UA74_08635 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) UA74_08645 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) UA74_08650 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UA74_08690 ENOG41073TP transcriptional regulator UA74_08705 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) UA74_08710 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) UA74_08720 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA74_08730 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) UA74_08750 ENOG4105DGU Histone deacetylase UA74_08770 ENOG4105BZU Histidine kinase UA74_08775 ENOG4108KXV response regulator UA74_08785 ENOG4105C6Z Gluconate UA74_08790 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family UA74_08825 ENOG4105K5M 30s ribosomal protein S16 UA74_08835 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) UA74_08840 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) UA74_08845 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) UA74_08850 ENOG4107QYR Signal peptidase i UA74_08855 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) UA74_08875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA74_08880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_08890 ENOG4108JQ7 (ABC) transporter UA74_08895 ENOG4105CNT hydrolase family 2 UA74_08900 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) UA74_08905 ENOG41080R2 UPF0102 protein UA74_08910 ENOG4105C0P Mg chelatase subunit ChlI UA74_08920 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UA74_08925 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) UA74_08940 ENOG4105CE9 30S ribosomal protein S2 UA74_08945 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) UA74_08950 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) UA74_08955 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) UA74_08965 ENOG41089UC methyltransferase, type 11 UA74_08970 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs UA74_08985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UA74_08995 ENOG4105F38 ABC transporter, permease UA74_09000 ENOG4105D38 putrescine abc transporter UA74_09005 ENOG4105Y3U Transglycosylase-associated protein UA74_09010 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) UA74_09020 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) UA74_09040 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) UA74_09065 ENOG4105DJ2 Major Facilitator Superfamily UA74_09085 ENOG4108V1U phospholipid-binding protein UA74_09095 ENOG4105BZU Histidine kinase UA74_09100 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_09130 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap UA74_09165 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) UA74_09170 ENOG4105C1J atp-dependent rna helicase UA74_09180 ENOG4107XFJ UPF0246 protein UA74_09190 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) UA74_09200 ENOG4105DEN Luciferase family UA74_09230 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) UA74_09255 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) UA74_09260 ENOG41061TZ Short-chain dehydrogenase reductase Sdr UA74_09340 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) UA74_09365 ENOG4107QZF nitrite reductase NADPH large subunit UA74_09370 ENOG4107QZF nitrite reductase NADPH large subunit UA74_09375 ENOG4105DQQ Major facilitator superfamily MFS_1 UA74_09380 ENOG4108IFG nitrite reductase, (NAD(P)H) UA74_09385 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) UA74_09390 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) UA74_09400 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) UA74_09405 ENOG4105C1V Peptidase, M16 UA74_09410 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) UA74_09435 ENOG4108JJA ABC, transporter UA74_09465 ENOG4105T0Z Conserved Protein UA74_09480 ENOG4105E4C Lytic transglycosylase catalytic UA74_09485 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) UA74_09490 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA74_09495 ENOG4105CN5 Metallo-Beta-Lactamase UA74_09510 ENOG4107QZI cell division protein FtsK UA74_09530 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) UA74_09540 ENOG4108I62 cina-like protein UA74_09545 ENOG4105WBV Transcriptional regulator UA74_09565 ENOG4105C2W permease UA74_09570 ENOG4107SKI cobyrinic Acid a,c-diamide synthase UA74_09595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 UA74_09600 ENOG4108V6E Cell division protein mraZ UA74_09605 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) UA74_09615 ENOG4105CJN penicillin-binding protein UA74_09630 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) UA74_09635 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) UA74_09650 ENOG4105DFU Cell wall formation (By similarity) UA74_09655 ENOG4105ME9 cell division protein FtsQ UA74_09660 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone UA74_09670 ENOG4107R7A Allophanate hydrolase subunit 2 UA74_09680 ENOG4105E7W lamb ycsf family protein UA74_09685 ENOG4105CMG Carbohydrate kinase UA74_09700 ENOG4105DFA alanine racemase domain protein UA74_09705 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) UA74_09715 ENOG4107VQS DivIVA family UA74_09720 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) UA74_09750 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) UA74_09775 ENOG4105CHR reductase UA74_09785 ENOG4106A3M Cytochrome p-450 UA74_09790 ENOG4106A3M Cytochrome p-450 UA74_09795 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) UA74_09800 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) UA74_09810 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) UA74_09830 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) UA74_09835 ENOG4108IYU L-aspartate oxidase UA74_09875 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_09885 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) UA74_09890 ENOG4105CIH Imidazole acetol-phosphate transaminase UA74_09915 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase UA74_09925 ENOG4105ECC imidazole-glycerol-phosphate dehydratase UA74_09935 ENOG4108Z4X TRANSCRIPTIONal UA74_09940 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) UA74_09950 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase UA74_09965 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) UA74_09975 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase UA74_10025 ENOG4108X07 Tetr family transcriptional regulator UA74_10040 ENOG4105DK0 Indole-3-glycerol phosphate synthase UA74_10045 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) UA74_10050 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) UA74_10060 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) UA74_10065 ENOG4105CAT Cytidine monophosphate kinase UA74_10075 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) UA74_10095 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA74_10100 ENOG4105JHE Major Facilitator Superfamily UA74_10105 ENOG4105CZE histidine utilization repressor UA74_10110 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) UA74_10120 ENOG4105N14 lysine exporter protein LysE YggA UA74_10125 ENOG4105J0Q Transcriptional regulator UA74_10165 ENOG4105DIA mandelate racemase muconate lactonizing UA74_10170 ENOG4105ERH Fumarylacetoacetate hydrolase UA74_10195 ENOG4105EQK -acetyltransferase UA74_10235 ENOG4107XZC Restriction modification system DNA (Specificity UA74_10245 ENOG4105D9P serine threonine protein kinase UA74_10265 ENOG4105CHP RNA polymerase UA74_10270 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) UA74_10285 ENOG4105KVH Transcriptional regulator UA74_10290 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase UA74_10300 ENOG4105E4C Lytic transglycosylase catalytic UA74_10305 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) UA74_10325 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) UA74_10350 ENOG4105CAT Cytidine monophosphate kinase UA74_10385 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA74_10400 ENOG4105C1B dTDP-glucose 4-6-dehydratase UA74_10410 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase UA74_10415 ENOG4105DKP glycosyl transferase, family 9 UA74_10420 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) UA74_10425 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) UA74_10430 ENOG4105CHR reductase UA74_10440 ENOG4105C6Y Udp-glucose 6-dehydrogenase UA74_10455 ENOG4105C31 Tryptophanyl-tRNA synthetase UA74_10460 ENOG4105WCJ ec 1.1.1.193 UA74_10465 ENOG4107TXC Transcriptional regulator UA74_10470 ENOG4105CHH sulfate transporter UA74_10485 ENOG4107SET aldo keto reductase UA74_10500 ENOG4106T9R serine protease UA74_10520 ENOG4108YV4 Universal stress protein UA74_10535 ENOG4105C9U ATP-dependent DNA helicase RecQ UA74_10555 ENOG4105D22 carbon starvation protein UA74_10565 ENOG4105D0U Arsenite-activated ATPase (ArsA) UA74_10570 ENOG4105S6R Iron-hydroxamate transporter permease subunit UA74_10580 ENOG4105E0A ABC, transporter UA74_10610 ENOG4105C32 Amino acid ABC transporter (Permease) UA74_10615 ENOG4105CF8 branched-chain amino acid ABC transporter, permease UA74_10620 ENOG4105C0Z ABC transporter UA74_10625 ENOG4108IV0 ABC, transporter UA74_10630 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) UA74_10640 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase UA74_10660 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) UA74_10665 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) UA74_10670 ENOG4105EXC Acyl-transferase UA74_10675 ENOG4105EXC Acyl-transferase UA74_10680 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) UA74_10710 ENOG4105CJ1 ABC, transporter UA74_10720 ENOG4105CI2 imidazolone-5-propionate hydrolase UA74_10725 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA74_10755 ENOG4105C22 threonyL-tRNA synthetase UA74_10770 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase UA74_10775 ENOG4105E2K Glycosyl transferase (Group 1 UA74_10780 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) UA74_10795 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) UA74_10810 ENOG4108IMY Transcriptional regulator UA74_10825 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) UA74_10830 ENOG4105CDY transcriptional regulatory protein UA74_10850 ENOG4106A3M Cytochrome p-450 UA74_10855 ENOG4105DTD Dehydrogenase UA74_10870 ENOG4107STQ Multicopper oxidase UA74_10880 ENOG4105DUX Transporter UA74_10885 ENOG4107EXU Short-chain dehydrogenase reductase Sdr UA74_10895 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase UA74_10970 ENOG4105CAQ asparagine synthetase UA74_10975 ENOG4108K6T Protein of unknown function (DUF1205) UA74_10980 ENOG4105CHR reductase UA74_10995 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein UA74_11005 ENOG4105CZS beta-ketoacyl synthase UA74_11025 ENOG4105CHR reductase UA74_11040 ENOG4108DUX Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) UA74_11045 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein UA74_11050 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase UA74_11070 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily UA74_11075 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) UA74_11080 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) UA74_11085 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) UA74_11095 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) UA74_11100 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) UA74_11105 ENOG4107VMB Beta-lactamase domain protein UA74_11160 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) UA74_11165 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) UA74_11240 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap UA74_11255 ENOG4105KVH Transcriptional regulator UA74_11260 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UA74_11265 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UA74_11270 ENOG4107SIG periplasmic solute binding protein UA74_11275 ENOG4105DIK (ABC) transporter UA74_11280 ENOG4105CC5 ABC transporter UA74_11285 ENOG4107RBD ABC, transporter UA74_11290 ENOG4107STQ Multicopper oxidase UA74_11315 ENOG4108S4H thioesterase Superfamily protein UA74_11320 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) UA74_11335 ENOG4105F76 Sarcosine oxidase UA74_11385 ENOG4108UW8 fha domain-containing protein UA74_11405 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor UA74_11410 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) UA74_11430 ENOG4105DUX Transporter UA74_11435 ENOG4108Q5F Tetr family transcriptional regulator UA74_11440 ENOG4105D1K glutamate--cysteine ligase UA74_11445 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process UA74_11450 ENOG4108V75 Glutamine amidotransferase UA74_11455 ENOG41067HS methyltransferase UA74_11475 ENOG4107QM5 aconitate hydratase UA74_11490 ENOG4105ZXU NLP P60 protein UA74_11495 ENOG4107RSM transcriptional regulator UA74_11500 ENOG4105FDR Membrane UA74_11510 ENOG4105C7R Atpase associated with various cellular activities aaa_3 UA74_11520 ENOG4107QVM von Willebrand factor, type A UA74_11525 ENOG4105CHR reductase UA74_11535 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH UA74_11540 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) UA74_11545 ENOG410651K Teichoic acid biosynthesis protein C UA74_11555 ENOG4108UF8 UA74_11585 ENOG4105C26 Dehydrogenase UA74_11610 ENOG4105DV0 amidase (EC 3.5.1.4 UA74_11635 ENOG41073TP transcriptional regulator UA74_11645 ENOG4108JPW Aminotransferase UA74_11655 ENOG4105CT1 (ABC) transporter UA74_11680 ENOG4108UW8 fha domain-containing protein UA74_11685 ENOG4105D9P serine threonine protein kinase UA74_11700 ENOG4105CHU acetyl-coa acetyltransferase UA74_11705 ENOG4105EE5 Membrane protein terC UA74_11720 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase UA74_11725 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA74_11775 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) UA74_11840 ENOG410769Z extracellular solute-binding protein family 1 UA74_11850 ENOG4105JXH GntR family transcriptional regulator UA74_11855 ENOG4105CX8 fg-gap repeat protein UA74_11925 ENOG4105CPP Dehydrogenase, E1 component UA74_11930 ENOG4108JYK Dehydrogenase UA74_11955 ENOG4105CQ7 ATP-dependent helicase UA74_11975 ENOG4108VBZ doxx family UA74_11990 ENOG4105C9M aspartyl-trna synthetase UA74_12000 ENOG41082W1 Cupin 2, conserved barrel domain protein UA74_12045 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) UA74_12060 ENOG4105E2X shikimate dehydrogenase UA74_12100 ENOG4105FDP GntR family transcriptional regulator UA74_12110 ENOG4105C5Y PTS System UA74_12125 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase UA74_12130 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) UA74_12140 ENOG4105D49 3-dehydroquinate synthase UA74_12145 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) UA74_12150 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase UA74_12160 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) UA74_12165 ENOG4105DC7 peptidase M24 UA74_12170 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) UA74_12175 ENOG410803B Involved in the transcription termination process (By similarity) UA74_12185 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) UA74_12190 ENOG4105CXT aspartate transcarbamylase UA74_12205 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain UA74_12215 ENOG4105SKN orotidine 5''-phosphate decarboxylase UA74_12230 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) UA74_12240 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP UA74_12275 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) UA74_12280 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UA74_12295 ENOG4108J5H Homocysteine s-methyltransferase UA74_12310 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) UA74_12315 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) UA74_12330 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) UA74_12335 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) UA74_12345 ENOG4105CIE May be required for sporulation (By similarity) UA74_12350 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase UA74_12355 ENOG4105BZA Phosphoglycerate kinase UA74_12360 ENOG4105CP7 Triose-phosphate isomerase UA74_12395 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) UA74_12410 ENOG4107QP8 phosphohexose isomerase UA74_12415 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) UA74_12425 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) UA74_12470 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein UA74_12490 ENOG410600Z Regulatory protein MarR UA74_12505 ENOG4105CJ1 ABC, transporter UA74_12510 ENOG4107JC6 Membrane UA74_12535 ENOG4105C3K feS assembly ATPase SufC UA74_12545 ENOG4108UNV SUF system FeS assembly protein, NifU family UA74_12550 ENOG4105VG1 fes assembly suf system protein UA74_12570 ENOG4107XTP (EAL) domain protein UA74_12590 ENOG4105CHR reductase UA74_12600 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) UA74_12620 ENOG4105C5H ABC transporter UA74_12630 ENOG4105CGU Enoyl-CoA hydratase UA74_12645 ENOG4105KVH Transcriptional regulator UA74_12675 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) UA74_12705 ENOG4105CPQ Dehydrogenase UA74_12740 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) UA74_12750 ENOG4105EWU Squalene--hopene cyclase UA74_12755 ENOG4105EAH synthase UA74_12765 ENOG4105EBR Carboxylesterase UA74_12780 ENOG4105CJA serine threonine protein kinase UA74_12800 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase UA74_12805 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) UA74_12810 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) UA74_12815 ENOG41061CK Antibiotic biosynthesis monooxygenase UA74_12855 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) UA74_12870 ENOG4105PTV Nudix Hydrolase UA74_12875 ENOG4105E5F proteasome UA74_12880 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) UA74_12885 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) UA74_12890 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) UA74_12905 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) UA74_12915 ENOG4107TMB Transcriptional regulator UA74_12945 ENOG4105HHS UPF0256 protein UA74_12965 ENOG4105J0Q Transcriptional regulator UA74_12985 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) UA74_12990 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA74_13000 ENOG4105FS0 cytoplasmic membrane protein UA74_13005 ENOG4105EFZ amidohydrolase UA74_13015 ENOG4107NHD transcriptional regulator UA74_13035 ENOG4105CPC Aldo Keto reductase UA74_13070 ENOG4105BZ1 (ABC) transporter UA74_13080 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain UA74_13125 ENOG4105D9P serine threonine protein kinase UA74_13140 ENOG4105DQE DNA ligase UA74_13145 ENOG4105DQE DNA ligase UA74_13150 ENOG41080XP Cbs domain UA74_13155 ENOG4105CH6 catalase UA74_13165 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) UA74_13175 ENOG4105C09 Bile acid UA74_13185 ENOG4105F0K SARP family transcriptional regulator UA74_13190 ENOG4105CJA serine threonine protein kinase UA74_13210 ENOG4107ZR7 Membrane UA74_13225 ENOG4105DQ5 transport system permease protein UA74_13230 ENOG4105TVJ transport system, permease UA74_13235 ENOG4105E0A ABC, transporter UA74_13240 ENOG4105BZ1 (ABC) transporter UA74_13245 ENOG4105BZ1 (ABC) transporter UA74_13260 ENOG41082A2 Alpha beta hydrolase UA74_13265 ENOG4105EKC UA74_13300 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) UA74_13305 ENOG4108IG5 Transcriptional regulator UA74_13310 ENOG4105FCA ABC transporter periplasmic-binding protein YphF UA74_13315 ENOG4108F37 ATP-binding component of a transport system UA74_13320 ENOG4105CNN ABC, transporter UA74_13325 ENOG4105CPQ Dehydrogenase UA74_13340 ENOG4105EMF GntR family transcriptional regulator UA74_13345 ENOG4105CXK mandelate racemase muconate lactonizing UA74_13350 ENOG4108UHU Aldolase UA74_13355 ENOG4105D7K pfkb domain protein UA74_13380 ENOG4108IMY Transcriptional regulator UA74_13415 ENOG4107RSM transcriptional regulator UA74_13435 ENOG4107U9B transcriptional regulator UA74_13455 ENOG41080S5 HTH_DTXR UA74_13485 ENOG4105CHR reductase UA74_13490 ENOG4105EWI Short-chain dehydrogenase reductase Sdr UA74_13500 ENOG4108IV0 ABC, transporter UA74_13505 ENOG4105C0Z ABC transporter UA74_13515 ENOG4105C1G acyl-Coa dehydrogenase UA74_13520 ENOG4105CEY Amp-dependent synthetase and ligase UA74_13535 ENOG4105G9B Transcriptional regulator UA74_13550 ENOG4105CHU acetyl-coa acetyltransferase UA74_13555 ENOG4105C1G acyl-Coa dehydrogenase UA74_13580 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) UA74_13585 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) UA74_13590 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) UA74_13595 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) UA74_13620 ENOG4108JQ9 ABC transporter UA74_13640 ENOG4105CHR reductase UA74_13645 ENOG4107RSM transcriptional regulator UA74_13650 ENOG4105YIP Tetr family transcriptional regulator UA74_13675 ENOG4105GWZ Roadblock lc7 family protein UA74_13690 ENOG4105NAF rna polymerase sigma factor UA74_13775 ENOG4105FB9 CRISPR-associated protein UA74_13795 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) UA74_13800 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) UA74_13835 ENOG410905P Pyridoxamine 5-phosphate UA74_13860 ENOG4108IY8 ABC, transporter UA74_13870 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component UA74_13905 ENOG4108Z4X TRANSCRIPTIONal UA74_13925 ENOG4105C0R drug resistance transporter emrb qaca subfamily UA74_13930 ENOG4108ME1 Peptidase M55 D-aminopeptidase UA74_13940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA74_13945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_13965 ENOG4105VEQ Cold shock protein UA74_13975 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) UA74_13985 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A UA74_14035 ENOG4105EET magnesium chelatase UA74_14055 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_14095 ENOG4105C8N cysteinyl-tRNA synthetase UA74_14110 ENOG410814C multidrug resistance protein UA74_14120 ENOG4105C3R Methionine synthase UA74_14125 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) UA74_14135 ENOG4105BZN citrate synthase UA74_14150 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) UA74_14155 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UA74_14165 ENOG4108ZHR arsR family transcriptional regulator UA74_14175 ENOG4105C57 major facilitator superfamily UA74_14180 ENOG4105BZ1 (ABC) transporter UA74_14190 ENOG410769Z extracellular solute-binding protein family 1 UA74_14205 ENOG4105FB2 class II Aldolase UA74_14210 ENOG4105G63 Type III effector Hrp-dependent UA74_14220 ENOG4105C6Z Gluconate UA74_14225 ENOG4105MVE transcriptional regulator UA74_14240 ENOG4105J7D transcriptional regulator UA74_14250 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b UA74_14285 ENOG4105F27 Major Facilitator UA74_14300 ENOG4105CVK Glutamate decarboxylase UA74_14330 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 UA74_14355 ENOG4105QE3 oxidoreductase UA74_14370 ENOG4105C6N Formate acetyltransferase UA74_14380 ENOG4105C26 Dehydrogenase UA74_14405 ENOG4105G6Z alkaline phosphatase UA74_14415 ENOG4107RTD sua5 ycio yrdc ywlc family protein UA74_14420 ENOG4105E0A ABC, transporter UA74_14425 ENOG4105TVJ transport system, permease UA74_14430 ENOG4105DQ5 transport system permease protein UA74_14455 ENOG4105C57 major facilitator superfamily UA74_14465 ENOG4105YIP Tetr family transcriptional regulator UA74_14475 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family UA74_14480 ENOG4105C5H ABC transporter UA74_14485 ENOG4105CN8 Transcriptional regulator UA74_14500 ENOG4108UZX fmn reductase UA74_14510 ENOG4105CPQ Dehydrogenase UA74_14520 ENOG4105FBA Phospholipase Carboxylesterase UA74_14525 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase UA74_14530 ENOG4105CS1 NAD(P)H quinone oxidoreductase UA74_14535 ENOG41090MY MarR family Transcriptional regulator UA74_14540 ENOG4105F32 YngK protein UA74_14610 ENOG4105CPC Aldo Keto reductase UA74_14635 ENOG4105D74 hydrolase UA74_14640 ENOG4105DHI Methyltransferase UA74_14650 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein UA74_14670 ENOG4108V9W transcriptional regulatory protein UA74_14700 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) UA74_14710 ENOG4107W53 thymidine kinase UA74_14715 ENOG4105DEU major facilitator superfamily UA74_14730 ENOG4105BZU Histidine kinase UA74_14745 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UA74_14790 ENOG4105K6H D-cysteine desulfhydrase UA74_14830 ENOG4105KNA -acetyltransferase UA74_14835 ENOG4105ECR NmrA family UA74_14845 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase UA74_14860 ENOG4105BZ1 (ABC) transporter UA74_14865 ENOG4105BZ1 (ABC) transporter UA74_14890 ENOG4105C3M thioredoxin reductase UA74_14900 ENOG4105C0D helicase UA74_14920 ENOG4105V75 Transcriptional regulator UA74_14935 ENOG4105CSU acyl-Coa dehydrogenase UA74_14945 ENOG4108V8F Transcriptional regulator, MarR family UA74_14950 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase UA74_14965 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) UA74_14970 ENOG4107S9F NmrA family UA74_15015 ENOG4105ECR NmrA family UA74_15020 ENOG4105KVH Transcriptional regulator UA74_15030 ENOG4108IG5 Transcriptional regulator UA74_15045 ENOG4107SCK Monooxygenase UA74_15050 ENOG4105DDN Pentapeptide repeat-containing protein UA74_15055 ENOG4105YIP Tetr family transcriptional regulator UA74_15065 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr UA74_15100 ENOG4105E4C Lytic transglycosylase catalytic UA74_15115 ENOG4108R86 Transcriptional regulator UA74_15180 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) UA74_15185 ENOG4105EBR Carboxylesterase UA74_15200 ENOG4105CHP RNA polymerase UA74_15205 ENOG4105GRZ Ycii-related protein UA74_15215 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase UA74_15230 ENOG4108IG5 Transcriptional regulator UA74_15245 ENOG4108KTG Membrane protein, drug metabolite transporter UA74_15255 ENOG41065SU Two-component system sensor kinase UA74_15260 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_15285 ENOG4105GRZ Ycii-related protein UA74_15290 ENOG4105CHP RNA polymerase UA74_15295 ENOG4105C57 major facilitator superfamily UA74_15345 ENOG4105GRZ Ycii-related protein UA74_15360 ENOG4108IND Tetr family transcriptional regulator UA74_15365 ENOG4105DND Transcriptional regulator UA74_15370 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase UA74_15400 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) UA74_15410 ENOG4105C57 major facilitator superfamily UA74_15415 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) UA74_15430 ENOG4105CPC Aldo Keto reductase UA74_15440 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA74_15445 ENOG4105M2Z protein tyrosine serine phosphatase UA74_15465 ENOG4105C0D helicase UA74_15475 ENOG4105NAE bifunctional deaminase-reductase domain protein UA74_15480 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) UA74_15525 ENOG4105ECQ AraC Family Transcriptional Regulator UA74_15530 ENOG4108X0B nad(p)h dehydrogenase (quinone) UA74_15535 ENOG4107SET aldo keto reductase UA74_15560 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase UA74_15580 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) UA74_15585 ENOG4105DYW oxidoreductase UA74_15605 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) UA74_15675 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA74_15730 ENOG4105GFG DUF218 domain UA74_15765 ENOG4108IAJ Nad-dependent epimerase dehydratase UA74_15775 ENOG4105CEY Amp-dependent synthetase and ligase UA74_15785 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) UA74_15790 ENOG4108I0Q anthranilate phosphoribosyltransferase UA74_15820 ENOG4105DTT CRISPR-associated helicase, cas3 UA74_15830 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) UA74_15845 ENOG4105VTR Integrase UA74_15910 ENOG4105CVR type I restriction-modification system UA74_15920 ENOG4105CVR type I restriction-modification system UA74_15930 ENOG4105DZR Type I site-specific deoxyribonuclease UA74_16000 ENOG4105E6M Sulphatase-modifying factor protein UA74_16020 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) UA74_16050 ENOG4105C75 arginyL-tRNA synthetase UA74_16075 ENOG4105BZU Histidine kinase UA74_16170 ENOG4105GMT ATPase associated with various cellular activities aaa_5 UA74_16215 ENOG4105F9F transposase UA74_16225 ENOG41068JE domain protein UA74_16270 ENOG4105CEC DNA methylase N-4 N-6 UA74_16405 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_16635 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) UA74_16660 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) UA74_16675 ENOG410849S phosphocarrier protein (HPr) UA74_16680 ENOG4105DM4 PTS System UA74_16685 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN UA74_16690 ENOG4105DE4 1-phosphofructokinase UA74_16695 ENOG4105E98 transcriptional regulator DeoR family UA74_16705 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) UA74_16740 ENOG4105CHR reductase UA74_16745 ENOG4105H3G oxidoreductase UA74_16785 ENOG4105C57 major facilitator superfamily UA74_16840 ENOG4105EBR Carboxylesterase UA74_16845 ENOG4108W6C Dehydrogenase UA74_16865 ENOG4105QV4 Tryptophan halogenase UA74_16890 ENOG4105K5B UPF0225 protein UA74_16895 ENOG4105CIG ABC transporter UA74_16935 ENOG4105FKQ transcriptional regulator UA74_16940 ENOG4107VFM Dehydrogenase UA74_16965 ENOG4105CEY Amp-dependent synthetase and ligase UA74_16970 ENOG4105CEY Amp-dependent synthetase and ligase UA74_16975 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) UA74_16985 ENOG4105CTU Proline racemase UA74_17010 ENOG4105G3Z GntR family transcriptional regulator UA74_17030 ENOG4105C3U ABC transporter UA74_17040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_17045 ENOG4105DEF Extracellular solute-binding protein, family 5 UA74_17055 ENOG4108EUP Glycosyl hydrolase family 62 UA74_17090 ENOG4108YZG isomerase UA74_17095 ENOG4105CSH Transporter UA74_17100 ENOG4105CDH Citrulline--aspartate ligase UA74_17120 ENOG4105CEY Amp-dependent synthetase and ligase UA74_17140 ENOG4105CIF Ornithine Cyclodeaminase UA74_17160 ENOG41088SP formiminoglutamate hydrolase UA74_17175 ENOG4105E0A ABC, transporter UA74_17180 ENOG4105EHG Permease protein UA74_17225 ENOG4105CX8 fg-gap repeat protein UA74_17255 ENOG4105EEM helicase UA74_17285 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase UA74_17300 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_17325 ENOG4105C0R drug resistance transporter emrb qaca subfamily UA74_17425 ENOG4106NZI LysR family Transcriptional regulator UA74_17445 ENOG41061TZ Short-chain dehydrogenase reductase Sdr UA74_17455 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) UA74_17470 ENOG4105C6Y Udp-glucose 6-dehydrogenase UA74_17475 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) UA74_17480 ENOG4106YKD Cytochrome p-450 UA74_17485 ENOG4108DMH HTH_ARAC UA74_17505 ENOG41082YX Transcriptional regulator, arsr family UA74_17525 ENOG4108VQT Alpha beta hydrolase fold protein UA74_17530 ENOG4105C57 major facilitator superfamily UA74_17550 ENOG4105CMR udp-glucose 4-epimerase UA74_17565 ENOG4106YKD Cytochrome p-450 UA74_17645 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) UA74_17650 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) UA74_17680 ENOG4105D1F ATP-binding protein UA74_17685 ENOG4105PWE CRISPR-associated protein cas2 UA74_17690 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) UA74_17695 ENOG4108Y7V CRISPR-associated protein, Cse3 family UA74_17700 ENOG4108VWQ crispr-associated protein UA74_17730 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) UA74_17735 ENOG4108KPJ rna polymerase sigma factor UA74_17800 ENOG4105CJ1 ABC, transporter UA74_17810 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_17820 ENOG4105XEA Tetr family transcriptional regulator UA74_17835 ENOG4107SYN Glycosyl hydrolases family 43 UA74_17845 ENOG4105ETE Transcriptional regulator (LacI family UA74_17860 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component UA74_17865 ENOG4108JE9 extracellular solute-binding protein family 1 UA74_17870 ENOG4105ETE Transcriptional regulator (LacI family UA74_17890 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone UA74_17895 ENOG4108UZX fmn reductase UA74_17910 ENOG4107TXC Transcriptional regulator UA74_17915 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) UA74_17935 ENOG4105CUC YeeE YedE family protein UA74_17955 ENOG4105F0K SARP family transcriptional regulator UA74_17985 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein UA74_17990 ENOG4105EWK phytoene UA74_18055 ENOG4107Z3H Transcriptional regulator, TetR family UA74_18060 ENOG4107R13 MMPL domain protein UA74_18065 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase UA74_18070 ENOG4107SWG transcriptional regulator MERR family UA74_18080 ENOG4105CG3 alpha amylase, catalytic region UA74_18125 ENOG4105BZU Histidine kinase UA74_18160 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) UA74_18165 ENOG4105ETE Transcriptional regulator (LacI family UA74_18215 ENOG4105CKI cobalamin synthesis protein UA74_18220 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_18235 ENOG4105CNN ABC, transporter UA74_18240 ENOG4105C2J ABC transporter UA74_18250 ENOG4105JXH GntR family transcriptional regulator UA74_18255 ENOG4105H9W Short-chain dehydrogenase reductase Sdr UA74_18285 ENOG4105E2A Dehydrogenase UA74_18310 ENOG41062B0 ABC transporter, permease UA74_18315 ENOG4107R9N ABC transporter UA74_18320 ENOG4105C2J ABC transporter UA74_18325 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator UA74_18330 ENOG4105CNT hydrolase family 2 UA74_18335 ENOG4105E98 transcriptional regulator DeoR family UA74_18360 ENOG4107S5I aldo keto reductase UA74_18420 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_18560 ENOG4105CHP RNA polymerase UA74_18585 ENOG4107SQU synthase UA74_18595 ENOG41068W2 Cytochrome p-450 UA74_18655 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) UA74_18675 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) UA74_18720 ENOG4105XN3 extracellular solute-binding protein family 1 UA74_18730 ENOG4105DRS transport system, permease UA74_18740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA74_18745 ENOG4105C5I Dehydrogenase UA74_18760 ENOG4107HP6 Transcriptional regulator UA74_18765 ENOG4107FKK extracellular solute-binding protein family 1 UA74_18770 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component UA74_18780 ENOG4105CXK mandelate racemase muconate lactonizing UA74_18790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) UA74_18800 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UA74_18810 ENOG4107RSM transcriptional regulator UA74_18815 ENOG4107AQZ Membrane UA74_18820 ENOG4105ETE Transcriptional regulator (LacI family UA74_18860 ENOG4105DR3 abc transporter permease protein UA74_18865 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component UA74_18875 ENOG4107QK4 glycoside hydrolase, family 3 domain protein UA74_18890 ENOG4108VW9 Membrane UA74_18895 ENOG410905P Pyridoxamine 5-phosphate UA74_18925 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase UA74_18930 ENOG4105MHT Transcriptional regulator, ARSR family UA74_18940 ENOG41080RH Thioredoxin UA74_18945 ENOG4105RHY Pfam:UPF0157 UA74_18950 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UA74_18970 ENOG4105C38 Glycyl-tRNA synthetase beta subunit UA74_18985 ENOG4105E0A ABC, transporter UA74_18990 ENOG4105EHG Permease protein UA74_19005 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving UA74_19010 ENOG4105CGD Nad-dependent epimerase dehydratase UA74_19015 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA74_19100 ENOG4108I5C dEAD DEAH box helicase UA74_19110 ENOG4105C0D helicase UA74_19150 ENOG4105SC1 monovalent cation H antiporter subunit E UA74_19155 ENOG4108JPZ Monovalent cation H antiporter subunit D UA74_19160 ENOG4105MKQ Monovalent cation H antiporter subunit C UA74_19165 ENOG4105D65 subunit l UA74_19180 ENOG4105CIG ABC transporter UA74_19185 ENOG4107ZYR domain protein UA74_19190 ENOG4105CZN Potassium uptake protein UA74_19195 ENOG4106F60 Histidine kinase UA74_19200 ENOG4105F44 Two component transcriptional regulator, winged helix family UA74_19210 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) UA74_19255 ENOG4105EYF MMPL domain protein UA74_19320 ENOG4105C01 Dihydroxy-acid dehydratase UA74_19355 ENOG4105KPY Small multidrug resistance protein UA74_19360 ENOG4105F6U Short-chain dehydrogenase reductase Sdr UA74_19365 ENOG4108IND Tetr family transcriptional regulator UA74_19385 ENOG4105TVJ transport system, permease UA74_19390 ENOG4105DQ5 transport system permease protein UA74_19415 ENOG4105Y3U Transglycosylase-associated protein UA74_19430 ENOG4105KKX ATPase associated with various cellular activities aaa_5 UA74_19435 ENOG4105DEG Vwa containing coxe family protein UA74_19460 ENOG4105C57 major facilitator superfamily UA74_19480 ENOG41082BM Transcriptional regulator, arsr family UA74_19485 ENOG4105CAY ferredoxin--nadp reductase UA74_19515 ENOG4105CPQ Dehydrogenase UA74_19520 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component UA74_19525 ENOG4105D56 permease protein UA74_19535 ENOG4108UHU Aldolase UA74_19565 ENOG4105C22 threonyL-tRNA synthetase UA74_19570 ENOG4105F1N DNA alkylation repair UA74_19600 ENOG4105CC5 ABC transporter UA74_19605 ENOG4105E0A ABC, transporter UA74_19610 ENOG4105C7K acetolactate synthase UA74_19630 ENOG4105EPH radical SAM domain protein UA74_19640 ENOG4106A3M Cytochrome p-450 UA74_19660 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) UA74_19690 ENOG41082BM Transcriptional regulator, arsr family UA74_19695 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase UA74_19790 ENOG4105CQB FAD linked oxidase domain protein UA74_19805 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_19825 ENOG4105DE4 1-phosphofructokinase UA74_19845 ENOG4107QNK )-transporter UA74_19850 ENOG4105E2D ec 3.2.1.52 UA74_19880 ENOG4108KDT Molybdate metabolism regulator UA74_19890 ENOG4108KDT Molybdate metabolism regulator UA74_19895 ENOG4105KKX ATPase associated with various cellular activities aaa_5 UA74_19900 ENOG4105RD5 UA74_19905 ENOG4105DEG Vwa containing coxe family protein UA74_19910 ENOG410903U zinc ion binding UA74_19915 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_19930 ENOG4108MXF Alpha Beta Hydrolase UA74_19960 ENOG41073TP transcriptional regulator UA74_19970 ENOG4105CMT Dihydroxyacetone kinase UA74_19975 ENOG4107YVI ribose 5-phosphate isomerase UA74_19980 ENOG4105CP7 Triose-phosphate isomerase UA74_19985 ENOG4108KFM Xylose Isomerase Domain-Containing protein UA74_19990 ENOG4106J7G oxidoreductase UA74_20000 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) UA74_20010 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) UA74_20020 ENOG4107U2T alpha beta UA74_20025 ENOG4108IJ9 (ABC) transporter UA74_20080 ENOG4105FS7 Transcriptional regulator UA74_20085 ENOG4105CIR epoxide hydrolase UA74_20130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_20135 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) UA74_20165 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) UA74_20270 ENOG4105D9P serine threonine protein kinase UA74_20315 ENOG4106A3M Cytochrome p-450 UA74_20325 ENOG4105TVJ transport system, permease UA74_20330 ENOG4105DQ5 transport system permease protein UA74_20335 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein UA74_20340 ENOG4108478 ec 3.2.1.18 UA74_20355 ENOG4108IND Tetr family transcriptional regulator UA74_20380 ENOG4108V15 phosphotransferase enzyme family UA74_20425 ENOG4105VEQ Cold shock protein UA74_20430 ENOG4105W1N transcriptional regulator UA74_20445 ENOG4105K6H D-cysteine desulfhydrase UA74_20450 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA74_20470 ENOG4105GZI Transcriptional regulator UA74_20475 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA74_20490 ENOG4105EFA 4-hydroxyphenylacetate UA74_20495 ENOG4105KME endoribonuclease L-psp UA74_20505 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit UA74_20510 ENOG4105RE0 Asp Glu hydantoin racemase UA74_20520 ENOG4105CG6 trap dicarboxylate transporter dctm subunit UA74_20525 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA74_20550 ENOG4105D9P serine threonine protein kinase UA74_20585 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) UA74_20620 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) UA74_20630 ENOG4105EX0 alpha-galactosidase UA74_20640 ENOG4105CPQ Dehydrogenase UA74_20645 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) UA74_20655 ENOG41080R8 Conserved Protein UA74_20660 ENOG4105M6F mutator MutT protein UA74_20675 ENOG4108KXV response regulator UA74_20680 ENOG41065SU Two-component system sensor kinase UA74_20690 ENOG4105EXC Acyl-transferase UA74_20700 ENOG4107TTA Xylose isomerase domain protein TIM barrel UA74_20710 ENOG4105CNN ABC, transporter UA74_20715 ENOG4105CNN ABC, transporter UA74_20720 ENOG4105C2J ABC transporter UA74_20800 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) UA74_20805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA74_20845 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA74_20850 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_20860 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) UA74_20930 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_21015 ENOG41088YS Glycosyl transferase (Group 1 UA74_21025 ENOG4108YUY UA74_21035 ENOG4105CHR reductase UA74_21040 ENOG41064E2 Xylose isomerase-like TIM barrel UA74_21045 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 UA74_21050 ENOG4108KK4 3-dehydroquinate synthase UA74_21060 ENOG4105CYP glycoside hydrolase, family UA74_21075 ENOG4105DRS transport system, permease UA74_21090 ENOG4105ETE Transcriptional regulator (LacI family UA74_21100 ENOG4105DAA L-lactate UA74_21110 ENOG4105CHR reductase UA74_21115 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) UA74_21130 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA74_21135 ENOG4108BT0 50S ribosomal protein L32 UA74_21140 ENOG4105NRA 50s ribosomal protein l31 type b UA74_21155 ENOG4105W0E 50S ribosomal protein L33 UA74_21160 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) UA74_21165 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) UA74_21170 ENOG4105CV8 reductase UA74_21180 ENOG4105BZF Glycosyl transferase (Group 1 UA74_21185 ENOG4108RZE Tetr family transcriptional regulator UA74_21190 ENOG4105CJ1 ABC, transporter UA74_21200 ENOG4105WX6 Membrane UA74_21210 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase UA74_21230 ENOG4105DR5 peptidase UA74_21260 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) UA74_21265 ENOG4105BZ4 penicillin-binding protein UA74_21275 ENOG4105CHH sulfate transporter UA74_21295 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) UA74_21300 ENOG4105DY8 decarboxylase UA74_21310 ENOG4105C29 acyl-CoA thioesterase UA74_21325 ENOG4105IIU Aminopeptidase UA74_21340 ENOG4105CBC glutamate synthase UA74_21345 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) UA74_21350 ENOG4105EHG Permease protein UA74_21355 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) UA74_21380 ENOG4105CPP Dehydrogenase, E1 component UA74_21455 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) UA74_21460 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) UA74_21495 ENOG4108ZGX Histidine kinase UA74_21500 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_21520 ENOG4108YZ4 nudix hydrolase UA74_21525 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) UA74_21545 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) UA74_21560 ENOG4105DSU hydrolase UA74_21590 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) UA74_21595 ENOG4108VX5 3-methyladenine DNA glycosylase UA74_21600 ENOG4105CH7 arginosuccinase UA74_21610 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) UA74_21615 ENOG4105DBV ornithine carbamoyltransferase UA74_21625 ENOG4105CAS nag kinase UA74_21630 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) UA74_21635 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase UA74_21660 ENOG4105D63 family UPF0324 UA74_21665 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) UA74_21670 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) UA74_21685 ENOG4108RWN rrna methyltransferase UA74_21690 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) UA74_21695 ENOG41084BS 50S ribosomal protein L35 UA74_21740 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) UA74_21765 ENOG4108K8S endonuclease I UA74_21810 ENOG4105BZW Glycerate kinase UA74_21825 ENOG4105BZU Histidine kinase UA74_21850 ENOG4107EEY synthase UA74_21885 ENOG4105EMU Dehydrogenase UA74_21895 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone UA74_21940 ENOG41082BM Transcriptional regulator, arsr family UA74_21965 ENOG4108TKH Nitroreductase UA74_21985 ENOG4105K6V RNA polymerase UA74_21990 ENOG4105KF0 sporulation and cell division protein, SsgA UA74_22065 ENOG4105CPC Aldo Keto reductase UA74_22075 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) UA74_22095 ENOG4108RFG Tetr family transcriptional regulator UA74_22100 ENOG4106UW1 Major Facilitator superfamily UA74_22115 ENOG4105DDC Oxidoreductase domain protein UA74_22135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_22140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA74_22150 ENOG4105CK5 oxidoreductase UA74_22165 ENOG4105ETE Transcriptional regulator (LacI family UA74_22170 ENOG4105DEI Mannitol dehydrogenase UA74_22175 ENOG4105CTX dehydratase UA74_22180 ENOG4105CE4 GlcNAc 6-P deacetylase UA74_22185 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) UA74_22190 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA74_22195 ENOG4108X07 Tetr family transcriptional regulator UA74_22220 ENOG4105E0A ABC, transporter UA74_22235 ENOG4105EHG Permease protein UA74_22265 ENOG4105EMF GntR family transcriptional regulator UA74_22280 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component UA74_22285 ENOG4105DRS transport system, permease UA74_22300 ENOG4108KEZ Dehydrogenase UA74_22310 ENOG41082A2 Alpha beta hydrolase UA74_22315 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F UA74_22335 ENOG4105DJB Major Facilitator Superfamily UA74_22345 ENOG4105EBM Alpha Beta Hydrolase Fold protein UA74_22390 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_22395 ENOG4108ZGX Histidine kinase UA74_22405 ENOG4107STQ Multicopper oxidase UA74_22420 ENOG4106A3M Cytochrome p-450 UA74_22425 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) UA74_22440 ENOG4105UNS Pfam:DUF419 UA74_22445 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit UA74_22470 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) UA74_22480 ENOG4105DEF Extracellular solute-binding protein, family 5 UA74_22490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_22500 ENOG4108JQ7 (ABC) transporter UA74_22515 ENOG4105KVH Transcriptional regulator UA74_22520 ENOG41069M3 Transcriptional regulator UA74_22525 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_22575 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) UA74_22625 ENOG4105C5I Dehydrogenase UA74_22635 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase UA74_22640 ENOG4106NZI LysR family Transcriptional regulator UA74_22645 ENOG4105DEF Extracellular solute-binding protein, family 5 UA74_22655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA74_22665 ENOG4108JQ7 (ABC) transporter UA74_22680 ENOG4105MHT Transcriptional regulator, ARSR family UA74_22690 ENOG4107TCW O-succinylbenzoate synthase UA74_22700 ENOG4105C5I Dehydrogenase UA74_22710 ENOG4105EQX glucarate dehydratase UA74_22715 ENOG4105KME endoribonuclease L-psp UA74_22720 ENOG4105J4Q Transcriptional regulator UA74_22725 ENOG4105D7K pfkb domain protein UA74_22730 ENOG4108UHU Aldolase UA74_22735 ENOG4105CWC Acetylornithine deacetylase UA74_22750 ENOG4108I5G Major Facilitator superfamily UA74_22775 ENOG4105CPC Aldo Keto reductase UA74_22785 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA74_22855 ENOG4107QNK )-transporter UA74_22875 ENOG4105C57 major facilitator superfamily UA74_22880 ENOG4105C57 major facilitator superfamily UA74_22900 ENOG4105DKT Transcriptional regulator UA74_22905 ENOG4105CPQ Dehydrogenase UA74_22950 ENOG4108TAG Histidine kinase UA74_22955 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) UA74_22975 ENOG4106A3M Cytochrome p-450 UA74_22980 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) UA74_22985 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_22995 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) UA74_23005 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) UA74_23080 ENOG4108VWQ crispr-associated protein UA74_23085 ENOG41060M0 Crispr-associated protein, cse4 family UA74_23120 ENOG4105CX8 fg-gap repeat protein UA74_23125 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) UA74_23185 ENOG41060M0 Crispr-associated protein, cse4 family UA74_23190 ENOG4108VWQ crispr-associated protein UA74_23215 ENOG4105DWV Homoserine O-trans-acetylase UA74_23225 ENOG4105BZM domain protein UA74_23250 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid UA74_23275 ENOG4105BZU Histidine kinase UA74_23280 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_23285 ENOG4105C4M (Ubiquinol oxidase) subunit I UA74_23295 ENOG4108JJ9 ABC, transporter UA74_23300 ENOG4108JJ8 (ABC) transporter UA74_23325 ENOG4105CX8 fg-gap repeat protein UA74_23380 ENOG4105Q26 Siderophore-interacting protein UA74_23435 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA74_23440 ENOG41082AN stage II sporulation protein UA74_23480 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) UA74_23490 ENOG4108Z0Z intracellular protease Pfpi family UA74_23545 ENOG4107R33 ppx gppa phosphatase UA74_23555 ENOG4105ETE Transcriptional regulator (LacI family UA74_23575 ENOG41060NJ transcriptional regulator UA74_23625 ENOG4105C8Y Acetylornithine aminotransferase UA74_23630 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) UA74_23680 ENOG4105CUT histidyl-tRNA synthetase UA74_23700 ENOG4105E0X reductase UA74_23710 ENOG4107JTW chlorite dismutase UA74_23715 ENOG4105C1Q protoporphyrinogen oxidase UA74_23720 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) UA74_23730 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_23745 ENOG4105CHU acetyl-coa acetyltransferase UA74_23750 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase UA74_23765 ENOG4105DIA mandelate racemase muconate lactonizing UA74_23785 ENOG410769Z extracellular solute-binding protein family 1 UA74_23790 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component UA74_23795 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component UA74_23810 ENOG4108J20 pectate lyase UA74_23815 ENOG4108J20 pectate lyase UA74_23820 ENOG4105E4I Glycoside hydrolase family 28 UA74_23835 ENOG410769Z extracellular solute-binding protein family 1 UA74_23840 ENOG4105DET Rhamnulokinase UA74_23855 ENOG4105C9F isomerase UA74_23865 ENOG4105ETE Transcriptional regulator (LacI family UA74_23870 ENOG4105C4C beta-galactosidase UA74_23875 ENOG4105DDC Oxidoreductase domain protein UA74_23915 ENOG4108E16 pectate lyase UA74_23920 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) UA74_23940 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA74_23950 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_23970 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component UA74_23980 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component UA74_23990 ENOG4108I5U Uridine phosphorylase UA74_23995 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) UA74_24020 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) UA74_24025 ENOG4105CD3 dihydroorotase UA74_24060 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) UA74_24105 ENOG4107V2S Transcriptional regulator UA74_24115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA74_24120 ENOG4105ETE Transcriptional regulator (LacI family UA74_24160 ENOG4105ETE Transcriptional regulator (LacI family UA74_24165 ENOG4105ETE Transcriptional regulator (LacI family UA74_24180 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component UA74_24185 ENOG4105I1K ABC transporter UA74_24220 ENOG4105DRS transport system, permease UA74_24230 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) UA74_24250 ENOG4107S1E Beta-lactamase UA74_24260 ENOG4105DHF Membrane UA74_24275 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_24280 ENOG4105BZU Histidine kinase UA74_24290 ENOG4108M15 ABC transporter UA74_24300 ENOG4105ECQ AraC Family Transcriptional Regulator UA74_24310 ENOG4105DTD Dehydrogenase UA74_24320 ENOG4105CIR epoxide hydrolase UA74_24340 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) UA74_24350 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) UA74_24355 ENOG4108KPJ rna polymerase sigma factor UA74_24365 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein UA74_24375 ENOG4105EC3 peptidase S51, dipeptidase E UA74_24380 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) UA74_24415 ENOG4108PJD permease UA74_24425 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) UA74_24450 ENOG4105CZV ABC transporter UA74_24455 ENOG4105FDP GntR family transcriptional regulator UA74_24460 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) UA74_24465 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) UA74_24490 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) UA74_24500 ENOG4107YU2 histidine triad (hIT) protein UA74_24510 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) UA74_24515 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) UA74_24525 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) UA74_24535 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) UA74_24555 ENOG4108IY8 ABC, transporter UA74_24585 ENOG41067XF inhibitor UA74_24595 ENOG4105CB2 alcohol dehydrogenase UA74_24610 ENOG4107QWG 2-Nitropropane dioxygenase UA74_24625 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA74_24630 ENOG4107QRT dEAD DEAH box helicase UA74_24680 ENOG41090CE integral membrane protein UA74_24705 ENOG4105DZ6 Band 7 protein UA74_24725 ENOG4108QXE glycerophosphoryl diester phosphodiesterase UA74_24765 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase UA74_24780 ENOG4105CNA YD repeat protein UA74_24825 ENOG4105E9Q Acyl-transferase UA74_24840 ENOG4105DKQ ROK family UA74_24875 ENOG4105JNK Glycosyl transferase (Group 1 UA74_24885 ENOG4105K4H Nlp p60 protein UA74_24915 ENOG4107UDY cytochrome C UA74_24920 ENOG4105CCU oxidase (Subunit III) UA74_24935 ENOG4107S1N anthranilate phosphoribosyltransferase UA74_24940 ENOG4108ZRS Part of cytochrome c oxidase, its function is UA74_24945 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) UA74_25015 ENOG4105CPC Aldo Keto reductase UA74_25025 ENOG4108YZT Adenosylcobinamide kinase UA74_25030 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) UA74_25035 ENOG41080Z7 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) UA74_25040 ENOG4105CM2 brancheD-chain amino acid aminotransferase UA74_25055 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) UA74_25080 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) UA74_25095 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) UA74_25110 ENOG4105C5F glutamine synthetase UA74_25125 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) UA74_25130 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UA74_25155 ENOG4105C5F glutamine synthetase UA74_25165 ENOG4105C4K Nad synthetase UA74_25175 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) UA74_25180 ENOG4105CHF Glutathione S-transferase UA74_25210 ENOG4105ZXU NLP P60 protein UA74_25255 ENOG4105CVJ phosphoglycerate mutase UA74_25320 ENOG4105DQ4 alcohol dehydrogenase UA74_25345 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) UA74_25360 ENOG4105CJW magnesium transporter UA74_25420 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) UA74_25425 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) UA74_25455 ENOG4107QN2 dihydrolipoyl dehydrogenase UA74_25500 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) UA74_25505 ENOG4105CK7 Sodium proline symporter UA74_25540 ENOG4108375 Acylphosphatase (EC 3.6.1.7) UA74_25545 ENOG4105K4I Scp-like extracellular UA74_25565 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) UA74_25570 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) UA74_25575 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) UA74_25585 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) UA74_25590 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) UA74_25595 ENOG41084BZ 50S ribosomal protein L32 UA74_25615 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) UA74_25620 ENOG4106H78 methyltransferase UA74_25625 ENOG4105CHR reductase UA74_25635 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) UA74_25650 ENOG4105RHY Pfam:UPF0157 UA74_25695 ENOG4105CB5 ATP-dependent DNA helicase recG UA74_25705 ENOG4105VB9 50S ribosomal protein l28 UA74_25715 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) UA74_25735 ENOG4108Z0R Transferase UA74_25760 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family UA74_25770 ENOG4105DA5 (ABC) transporter UA74_25785 ENOG4105CPF Cell wall formation (By similarity) UA74_25790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA74_25805 ENOG4105C28 cystathionine UA74_25810 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase UA74_25820 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) UA74_25840 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) UA74_25845 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) UA74_25870 ENOG4105PAD Hydrolase UA74_25875 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) UA74_25885 ENOG4105ERH Fumarylacetoacetate hydrolase UA74_25905 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) UA74_25910 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) UA74_25915 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA74_25930 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase UA74_25935 ENOG4108ZP8 Acetolactate synthase small subunit UA74_25950 ENOG4105C01 Dihydroxy-acid dehydratase UA74_25975 ENOG4108762 serine threonine protein kinase UA74_25985 ENOG4108VGI doxx family UA74_25990 ENOG4108VGI doxx family UA74_26020 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) UA74_26035 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA74_26040 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) UA74_26045 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) UA74_26085 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) UA74_26105 ENOG4105C7B Threonine dehydratase UA74_26110 ENOG4105FDF Could be involved in DNA repair (By similarity) UA74_26145 ENOG4105C57 major facilitator superfamily UA74_26160 ENOG4105C1G acyl-Coa dehydrogenase UA74_26170 ENOG4107QX3 carboxylase UA74_26220 ENOG4105VG5 Membrane UA74_26235 ENOG4105EBM Alpha Beta Hydrolase Fold protein UA74_26240 ENOG4108K8K Transcriptional regulator UA74_26245 ENOG4105DCF alanine dehydrogenase UA74_26275 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 UA74_26300 ENOG4105CI2 imidazolone-5-propionate hydrolase UA74_26325 ENOG4105CGP Urocanate hydratase UA74_26330 ENOG4105C84 Histidine ammonia-lyase UA74_26360 ENOG4105E90 ABC transporter UA74_26365 ENOG4105E90 ABC transporter UA74_26370 ENOG4108IJ8 ABC transporter UA74_26380 ENOG4105BZU Histidine kinase UA74_26395 ENOG4108ZM9 phosphoglycerate mutase UA74_26415 ENOG4105CBD Diacylglycerol kinase UA74_26435 ENOG4105WMN AntiSigma factor UA74_26445 ENOG4108Z66 YbaK ebsC protein UA74_26455 ENOG4108RAV Conserved protein UA74_26465 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase UA74_26485 ENOG4105C26 Dehydrogenase UA74_26500 ENOG4105C2N RNA methyltransferase TrmH family group 3 UA74_26505 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 UA74_26515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving UA74_26520 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea UA74_26530 ENOG4108MKR lipoprotein lpqb UA74_26535 ENOG4105BZU Histidine kinase UA74_26540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family UA74_26555 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) UA74_26565 ENOG4105CUB amino acid UA74_26570 ENOG4105EIP mannose-6-phosphate isomerase UA74_26580 ENOG4105W49 UPF0434 protein UA74_26600 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA74_26610 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase UA74_26615 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) UA74_26635 ENOG4105C6F GntR Family Transcriptional Regulator UA74_26655 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA74_26660 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA74_26675 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA74_26690 ENOG4107TB5 TRANSCRIPTIONal UA74_26695 ENOG4107TB5 TRANSCRIPTIONal UA74_26715 ENOG4105CJ1 ABC, transporter UA74_26725 ENOG4105D4B ABC, transporter UA74_26730 ENOG4105CNN ABC, transporter UA74_26735 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane UA74_26740 ENOG4105C2J ABC transporter UA74_26755 ENOG4105C8V SAICAR synthetase UA74_26765 ENOG4105E0Y RtcB Protein UA74_26800 ENOG4108S0S Nucleotidyl transferase UA74_26805 ENOG4105E0F Histidine kinase UA74_26810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family UA74_26815 ENOG4107TK4 histidinol-phosphate phosphatase UA74_26845 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase UA74_26865 ENOG4105D8K carboxyl transferase UA74_26880 ENOG4105GRZ Ycii-related protein UA74_26890 ENOG4105VT3 DNA binding domain protein, excisionase family UA74_26900 ENOG4105C4Y ABC transporter UA74_26910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UA74_26915 ENOG4105C7F AcnD-accessory protein PrpF UA74_26920 ENOG4107R11 Transcriptional regulator UA74_26925 ENOG4107WR6 Maf-like protein UA74_26935 ENOG4105CK2 sodium dicarboxylate symporter UA74_26940 ENOG4108JIK carboxylase UA74_26970 ENOG4105C6V Glycerol-3-phosphate dehydrogenase UA74_26980 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) UA74_27020 ENOG4107RM1 amidohydrolase UA74_27070 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) UA74_27100 ENOG4105CNN ABC, transporter UA74_27105 ENOG4105C2J ABC transporter UA74_27115 ENOG4107S9F NmrA family UA74_27130 ENOG4105BZU Histidine kinase UA74_27135 ENOG4108M15 ABC transporter UA74_27145 ENOG4105E2R ROK family UA74_27155 ENOG4105W1N transcriptional regulator UA74_27185 ENOG4108JPZ Monovalent cation H antiporter subunit D UA74_27190 ENOG4105MKQ Monovalent cation H antiporter subunit C UA74_27200 ENOG4105D65 subunit l UA74_27205 ENOG4105D5P Methylmalonyl-coA mutase UA74_27210 ENOG4107TPY serine threonine protein kinase UA74_27220 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain UA74_27225 ENOG4105CPC Aldo Keto reductase UA74_27235 ENOG41086VY Fic/DOC family UA74_27255 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) UA74_27270 ENOG4107S5I aldo keto reductase UA74_27275 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) UA74_27280 ENOG4107RZZ dna polymerase iii epsilon subunit UA74_27395 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) UA74_27400 ENOG4105C26 Dehydrogenase UA74_27405 ENOG4105C26 Dehydrogenase UA74_27455 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) UA74_27485 ENOG4108JQ9 ABC transporter UA74_27490 ENOG4105DIH basic membrane UA74_27520 ENOG4107H3J ribonuclease UA74_27540 ENOG4105CGK Exodeoxyribonuclease III UA74_27580 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) UA74_27595 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) UA74_27630 ENOG4105C0B DNA polymerase III (alpha subunit) UA74_27655 ENOG4105DC1 bifunctional purine biosynthesis protein purh UA74_27680 ENOG4105CMV Succinyl-CoA synthetase subunit beta UA74_27695 ENOG4105DR5 peptidase UA74_27700 ENOG41063SB peptidase UA74_27710 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_27790 ENOG4107TPY serine threonine protein kinase UA74_27795 ENOG4105RQF LysR family Transcriptional regulator UA74_27800 ENOG4105FR1 rard protein UA74_27825 ENOG4105ETE Transcriptional regulator (LacI family UA74_27830 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UA74_27870 ENOG4107QVP Dehydrogenase UA74_27905 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA74_27910 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) UA74_27915 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) UA74_27920 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA74_27935 ENOG4105DGI Alkaline phosphatase UA74_27940 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) UA74_27945 ENOG41080E2 ribosomal-protein-alanine acetyltransferase UA74_27955 ENOG4107R9S Malate synthase UA74_27960 ENOG41069M3 Transcriptional regulator UA74_27970 ENOG4108097 ATP-binding protein UA74_27980 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) UA74_27990 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) UA74_28030 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) UA74_28035 ENOG4108UJD 30S ribosomal protein S9 UA74_28040 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) UA74_28060 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA74_28065 ENOG4105EC2 ftsk spoIIIe UA74_28075 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin UA74_28135 ENOG4105BZU Histidine kinase UA74_28180 ENOG4105EC2 ftsk spoIIIe UA74_28190 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) UA74_28195 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein UA74_28215 ENOG4108IUX (ABC) transporter UA74_28220 ENOG4105RHA ABC transporter, permease UA74_28225 ENOG4105CVP deoxyribo-dipyrimidine photolyase UA74_28240 ENOG4105CI2 imidazolone-5-propionate hydrolase UA74_28245 ENOG4107WI4 Aldose-1-epimerase UA74_28250 ENOG4105DVH amino acid UA74_28255 ENOG4105E8G Major facilitator Superfamily UA74_28260 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) UA74_28265 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) UA74_28295 ENOG4105BZ1 (ABC) transporter UA74_28305 ENOG4105FCS tRNA rRNA methyltransferase UA74_28315 ENOG4105E8G Major facilitator Superfamily UA74_28325 ENOG4105C7N Xanthine uracil vitamin C permease UA74_28350 ENOG4108N0W Major Facilitator superfamily UA74_28370 ENOG4105VEQ Cold shock protein UA74_28380 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) UA74_28390 ENOG4105JAB phenazine biosynthesis protein, phzf family UA74_28400 ENOG4105F4R Transcriptional regulator mode UA74_28405 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) UA74_28415 ENOG4105MS9 Resuscitation-promoting factor UA74_28465 ENOG4105GWZ Roadblock lc7 family protein UA74_28485 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component UA74_28500 ENOG4105CFI type iii restriction protein res subunit UA74_28525 ENOG4106N3A copper homeostasis protein cutc UA74_28550 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) UA74_28580 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) UA74_28615 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) UA74_28635 ENOG4106BRA Membrane UA74_28710 ENOG4105KVH Transcriptional regulator UA74_28725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) UA74_28735 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UA74_28745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA74_28750 ENOG4108VW9 Membrane UA74_28760 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase UA74_28765 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family UA74_28805 ENOG4105K64 Glycosyl transferase, family 2 UA74_28820 ENOG4105CMR udp-glucose 4-epimerase UA74_28840 ENOG4105D3Q Sugar transferase UA74_28870 ENOG4108KGH TRANSCRIPTIONal UA74_28880 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F UA74_28885 ENOG4105C1G acyl-Coa dehydrogenase UA74_28900 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) UA74_28925 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) UA74_28930 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 UA74_28995 ENOG4105CNU cell division protein FtsK UA74_29070 ENOG4105BZU Histidine kinase UA74_29085 ENOG4108UTW Plays a role in the regulation of phosphate uptake UA74_29095 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) UA74_29100 ENOG4105E2Z phosphate ABC transporter (Permease UA74_29115 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) UA74_29120 ENOG4107NHD transcriptional regulator UA74_29145 ENOG4105KHC sulfurtransferase UA74_29150 ENOG4105PKJ carbohydrate binding UA74_29155 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands UA74_29215 ENOG4105CXB phosphoribosylaminoimidazole synthetase UA74_29230 ENOG4105BZP glycoside hydrolase 15-related UA74_29235 ENOG4105BZU Histidine kinase UA74_29250 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii UA74_29255 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I UA74_29260 ENOG410839H phosphoribosylformylglycinamidine synthase UA74_29285 ENOG4105C83 adenylosuccinate lyase UA74_29295 ENOG4105NAF rna polymerase sigma factor UA74_29300 ENOG4107TXC Transcriptional regulator UA74_29315 ENOG4105KPY Small multidrug resistance protein UA74_29360 ENOG4105EEQ Na H antiporter UA74_29365 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis UA74_29430 ENOG4108RWP Major Facilitator Superfamily protein UA74_29485 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) UA74_29490 ENOG4105CE4 GlcNAc 6-P deacetylase UA74_29500 ENOG4105CQB FAD linked oxidase domain protein UA74_29510 ENOG4105WH1 Two component transcriptional regulator luxr family UA74_29520 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) UA74_29540 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) UA74_29545 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA74_29590 ENOG4105BZG amino acid carrier protein UA74_29595 ENOG4105C8P )-transporter UA74_29600 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit UA74_29610 ENOG4105PDP Short chain dehydrogenase UA74_29620 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) UA74_29665 ENOG4108V0P LemA family UA74_29670 ENOG4105C2N RNA methyltransferase TrmH family group 3 UA74_29685 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) UA74_29695 ENOG4105KNI merR family transcriptional Regulator UA74_29700 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) UA74_29705 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ UA74_29710 ENOG4105CFG Acts as a chaperone (By similarity) UA74_29720 ENOG4105DF6 Fe-S oxidoreductase UA74_29725 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) UA74_29730 ENOG4105EHG Permease protein UA74_29755 ENOG4108PSK reductase UA74_29780 ENOG4105DHP deoxycytidine triphosphate deaminase UA74_29785 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 UA74_29805 ENOG4105CSU acyl-Coa dehydrogenase UA74_29835 ENOG4108RZE Tetr family transcriptional regulator UA74_29845 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) UA74_29880 ENOG4105CFC Transporter UA74_29890 ENOG4105CDA abc transporter atp-binding protein UA74_29895 ENOG4105E5Q amino acid AbC transporter UA74_29900 ENOG4107R0W ABC transporter UA74_29905 ENOG4105EAB amino acid AbC transporter UA74_29910 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) UA74_29920 ENOG4105CPP Dehydrogenase, E1 component UA74_29925 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 UA74_29940 ENOG4105EMU Dehydrogenase UA74_29980 ENOG4105BZ4 penicillin-binding protein UA74_30000 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) UA74_30005 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) UA74_30010 ENOG4107YH6 single-stranded DNA-binding protein UA74_30015 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) UA74_30020 ENOG4105K9Q Binds to the 23S rRNA (By similarity) UA74_30050 ENOG4106YKD Cytochrome p-450 UA74_30055 ENOG4108Z6Z Transcriptional regulator UA74_30065 ENOG4105VUF Transcriptional regulator UA74_30075 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA74_30080 ENOG4105F27 Major Facilitator UA74_30120 ENOG4105BZU Histidine kinase UA74_30140 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) UA74_30145 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) UA74_30150 ENOG4108RVA ribokinase UA74_30155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator UA74_30160 ENOG4105CNN ABC, transporter UA74_30165 ENOG4105C2J ABC transporter UA74_30170 ENOG4105ETE Transcriptional regulator (LacI family UA74_30195 ENOG4105C8T Leucyl-tRNA synthetase UA74_30205 ENOG4108UJU UPF0301 protein UA74_30215 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate UA74_30235 ENOG4107QPV Serine Threonine protein kinase UA74_30250 ENOG4105C3M thioredoxin reductase UA74_30255 ENOG4105K63 Thioredoxin UA74_30260 ENOG4108E1C hydrolase UA74_30270 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA74_30280 ENOG4105FA0 parb-like partition protein UA74_30285 ENOG4107QJE Chromosome Partitioning Protein UA74_30290 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) UA74_30295 ENOG4105CS9 pantothenic acid kinase UA74_30310 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) UA74_30315 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) UA74_30320 ENOG41084CH 50S ribosomal protein l34