locus-tag class description UA75_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) UA75_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) UA75_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase UA75_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA75_00025 ENOG4105K7N UPF0232 protein UA75_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) UA75_00070 ENOG4105DHF Membrane UA75_00095 ENOG4105XBB septation inhibitor protein UA75_00105 ENOG4108U4N (sortase) family UA75_00130 ENOG4105D9P serine threonine protein kinase UA75_00135 ENOG4107TPY serine threonine protein kinase UA75_00140 ENOG4105CJN penicillin-binding protein UA75_00155 ENOG4105HZM Fha domain containing protein UA75_00160 ENOG4105TV9 FHA Domain-Containing protein UA75_00170 ENOG4105C75 arginyL-tRNA synthetase UA75_00195 ENOG4108SGK Tetr family transcriptional regulator UA75_00230 ENOG4108T5E Copper resistance protein UA75_00245 ENOG4105C94 Transporter UA75_00250 ENOG4105E90 ABC transporter UA75_00255 ENOG4108IJ8 ABC transporter UA75_00260 ENOG4105E90 ABC transporter UA75_00265 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system UA75_00285 ENOG4107SET aldo keto reductase UA75_00335 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) UA75_00340 ENOG4105KRQ Addiction module toxin, Txe YoeB family UA75_00345 ENOG4105VTW prevent-host-death family UA75_00415 ENOG4107QN1 sodium solute UA75_00435 ENOG4105DY9 regulatoR UA75_00445 ENOG4108HRK Histidine kinase UA75_00465 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving UA75_00500 ENOG4107YEV ferritin UA75_00505 ENOG4105CEU Arginine dihydrolase UA75_00550 ENOG4105C4M (Ubiquinol oxidase) subunit I UA75_00555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii UA75_00560 ENOG4108JJ9 ABC, transporter UA75_00580 ENOG4108UVJ appr-1-p processing domain protein UA75_00610 ENOG4106032 Glutathionylspermidine synthase UA75_00615 ENOG4105P3N Membrane UA75_00640 ENOG410667J hydrolase UA75_00645 ENOG4105C1B dTDP-glucose 4-6-dehydratase UA75_00675 ENOG4105D5U fad dependent oxidoreductase UA75_00685 ENOG410602S Transferase UA75_00695 ENOG4108MKI Glycosyl transferase, family 2 UA75_00725 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein UA75_00735 ENOG4105IIU Aminopeptidase UA75_00800 ENOG4105CIH Imidazole acetol-phosphate transaminase UA75_00805 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) UA75_00810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) UA75_00840 ENOG4105CHU acetyl-coa acetyltransferase UA75_00850 ENOG4105EVN Prephenate dehydrogenase UA75_00860 ENOG4108Z6B deaminase UA75_00885 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) UA75_00910 ENOG410804X Transcriptional regulator UA75_00915 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) UA75_00925 ENOG4107QSI ABC, transporter UA75_00930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA75_00935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_00950 ENOG4105CPC Aldo Keto reductase UA75_00955 ENOG4105CNV Aldolase UA75_00965 ENOG4108JQ1 Dehydrogenase UA75_00970 ENOG4105CXK mandelate racemase muconate lactonizing UA75_00975 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) UA75_00995 ENOG4105CNN ABC, transporter UA75_01000 ENOG4105C2J ABC transporter UA75_01005 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator UA75_01030 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) UA75_01040 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein UA75_01045 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA75_01050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_01055 ENOG4105C3U ABC transporter UA75_01060 ENOG4108JQ7 (ABC) transporter UA75_01090 ENOG4105CFH Aspartokinase UA75_01105 ENOG4105CH6 catalase UA75_01120 ENOG4108ZHJ Organic hydroperoxide resistance protein UA75_01130 ENOG4106UDK Cellulose-binding, family II UA75_01145 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases UA75_01160 ENOG4105DIN metallophosphoesterase UA75_01175 ENOG4105BZ4 penicillin-binding protein UA75_01240 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) UA75_01280 ENOG4105D74 hydrolase UA75_01295 ENOG4105HF0 Membrane UA75_01320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) UA75_01325 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) UA75_01335 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate UA75_01340 ENOG4106KNT transcriptional regulator UA75_01365 ENOG4105FQP Beta-lactamase UA75_01370 ENOG4105EHZ conserved protein UCP016719 UA75_01375 ENOG4105D17 glycoside hydrolase, family 3 domain protein UA75_01430 ENOG4108I5C dEAD DEAH box helicase UA75_01435 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for UA75_01445 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) UA75_01455 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) UA75_01460 ENOG4107QRG dna polymerase iii UA75_01470 ENOG41068WN UA75_01480 ENOG4105C0B DNA polymerase III (alpha subunit) UA75_01485 ENOG4105EEM helicase UA75_01505 ENOG4105F0N pyrophosphate phospho-hydrolase UA75_01535 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) UA75_01545 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) UA75_01550 ENOG4105EUJ GTP cyclohydrolase i UA75_01600 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) UA75_01605 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) UA75_01610 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) UA75_01615 ENOG4105CRK lysyL-tRNA synthetase UA75_01630 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit UA75_01640 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) UA75_01655 ENOG4105CEN a g-specific adenine glycosylase UA75_01660 ENOG4106T9R serine protease UA75_01665 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) UA75_01675 ENOG4108VJ1 Transcriptional regulator (CarD family UA75_01680 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) UA75_01685 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) UA75_01695 ENOG4105C8N cysteinyl-tRNA synthetase UA75_01700 ENOG4105C2N RNA methyltransferase TrmH family group 3 UA75_01705 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein UA75_01745 ENOG4105ECY inositol monophosphatase UA75_01750 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) UA75_01760 ENOG4105CC5 ABC transporter UA75_01765 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UA75_01770 ENOG4105DSE periplasmic solute binding protein UA75_01780 ENOG4105EG2 ABC transporter, permease UA75_01785 ENOG4105D56 permease protein UA75_01810 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase UA75_01830 ENOG4105CPC Aldo Keto reductase UA75_01835 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase UA75_01840 ENOG4108JPW Aminotransferase UA75_01845 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) UA75_01850 ENOG4105EV8 ectoine hydroxylase UA75_01855 ENOG41065RQ ADP-ribosylation crystallin J1 UA75_01855 ENOG41065RQ ADP-ribosylation crystallin J1 UA75_01880 ENOG41073TP transcriptional regulator UA75_01895 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UA75_01900 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) UA75_01905 ENOG4105DWF phosphomethylpyrimidine kinase UA75_01920 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) UA75_01930 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) UA75_01935 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) UA75_01945 ENOG4105D9U N-acetyltransferase UA75_01950 ENOG4106T9R serine protease UA75_01955 ENOG4106T9R serine protease UA75_01960 ENOG4106T9R serine protease UA75_01965 ENOG4106T9R serine protease UA75_01970 ENOG4106T9R serine protease UA75_01975 ENOG4105FDP GntR family transcriptional regulator UA75_01985 ENOG4105D56 permease protein UA75_01990 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component UA75_01995 ENOG4105D17 glycoside hydrolase, family 3 domain protein UA75_02000 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) UA75_02010 ENOG4105BZU Histidine kinase UA75_02015 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_02025 ENOG41084I6 Protein CrcB homolog UA75_02030 ENOG41082CG Protein CrcB homolog UA75_02040 ENOG4105V9F hemagglutinin UA75_02045 ENOG4105TT9 Protein of unknown function (DUF2516) UA75_02115 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase UA75_02165 ENOG4105XEA Tetr family transcriptional regulator UA75_02185 ENOG4107R4N Cell wall formation (By similarity) UA75_02220 ENOG4105C57 major facilitator superfamily UA75_02230 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA75_02240 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) UA75_02245 ENOG4105BZU Histidine kinase UA75_02270 ENOG4105II7 pyrroline-5-carboxylate reductase UA75_02290 ENOG4108RXW HAD-superfamily subfamily IB hydrolase UA75_02300 ENOG4105C1G acyl-Coa dehydrogenase UA75_02320 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) UA75_02325 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) UA75_02335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) UA75_02340 ENOG4105D52 delta-aminolevulinic acid dehydratase UA75_02375 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase UA75_02380 ENOG4108RH7 phosphoglycerate mutase UA75_02395 ENOG4108762 serine threonine protein kinase UA75_02400 ENOG4107QIV Cytochrome c biogenesis protein UA75_02410 ENOG4105CRE cytochrome C UA75_02495 ENOG4108IPT Naphthoate synthase UA75_02500 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) UA75_02505 ENOG4105E4F Isochorismate synthase UA75_02520 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit UA75_02525 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit UA75_02530 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit UA75_02535 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit UA75_02540 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) UA75_02555 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA75_02570 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA75_02575 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain UA75_02580 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA75_02590 ENOG4107QIZ NADH dehydrogenase UA75_02595 ENOG4108IEH NADH dehydrogenase subunit g UA75_02600 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) UA75_02605 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA75_02610 ENOG41087XN oxidoreductase UA75_02615 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA75_02630 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) UA75_02650 ENOG4105DQU oxidoreductase, subunit beta UA75_02655 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein UA75_02660 ENOG4105F7P transcriptional regulator AsnC family UA75_02665 ENOG4105CIK Amidinotransferase UA75_02670 ENOG4106F60 Histidine kinase UA75_02675 ENOG4105F44 Two component transcriptional regulator, winged helix family UA75_02690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA75_02695 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA75_02705 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) UA75_02750 ENOG4105D0M Protease HtpX homolog UA75_02755 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) UA75_02770 ENOG4107S9F NmrA family UA75_02830 ENOG4105CNU cell division protein FtsK UA75_02860 ENOG4107ZVI PhiRv2 prophage protein UA75_02875 ENOG4108VPT UPF0234 protein UA75_02880 ENOG4105BZU Histidine kinase UA75_02895 ENOG4105WDJ 50S ribosomal protein L33 UA75_02900 ENOG410900P UPF0336 protein UA75_02930 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) UA75_02940 ENOG4108VZM 50s ribosomal protein L10 UA75_02945 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) UA75_02950 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UA75_02955 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UA75_03010 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) UA75_03015 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) UA75_03020 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) UA75_03025 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) UA75_03035 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) UA75_03040 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) UA75_03045 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) UA75_03050 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity UA75_03055 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) UA75_03060 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) UA75_03065 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) UA75_03070 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) UA75_03075 ENOG41082SA 50s ribosomal protein l29 UA75_03080 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal UA75_03085 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) UA75_03090 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) UA75_03095 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits UA75_03100 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) UA75_03105 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) UA75_03110 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) UA75_03115 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) UA75_03120 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) UA75_03125 ENOG410849U 50S ribosomal protein L30 UA75_03130 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) UA75_03190 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) UA75_03215 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits UA75_03220 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) UA75_03225 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) UA75_03230 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) UA75_03235 ENOG4108ZT0 50S ribosomal protein l17 UA75_03240 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) UA75_03260 ENOG4105BZU Histidine kinase UA75_03275 ENOG4105HNP -acetyltransferase UA75_03295 ENOG4105BZU Histidine kinase UA75_03305 ENOG4105EN6 Membrane UA75_03310 ENOG4105ETX regulatoR UA75_03315 ENOG41062D9 Histidine kinase UA75_03325 ENOG4105C0H protease UA75_03330 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) UA75_03345 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) UA75_03360 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase UA75_03365 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase UA75_03375 ENOG4105D9U N-acetyltransferase UA75_03420 ENOG4107QM2 Aldo Keto reductase UA75_03500 ENOG4105BZU Histidine kinase UA75_03525 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) UA75_03530 ENOG4105F8V Hydrolase, tatD family UA75_03535 ENOG4105MS9 Resuscitation-promoting factor UA75_03540 ENOG4108KE4 O-methyltransferase UA75_03550 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) UA75_03555 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UA75_03640 ENOG4108KPJ rna polymerase sigma factor UA75_03645 ENOG4105CEP NADH dehydrogenase UA75_03650 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) UA75_03655 ENOG4108UMI ABC transporter, permease UA75_03660 ENOG4105D01 (LipO)protein UA75_03670 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) UA75_03675 ENOG4107Y80 Major Facilitator superfamily UA75_03685 ENOG4105C5H ABC transporter UA75_03695 ENOG41061H0 Monooxygenase UA75_03715 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) UA75_03720 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) UA75_03735 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) UA75_03740 ENOG4105BZU Histidine kinase UA75_03755 ENOG41067SE Tetr family transcriptional regulator UA75_03790 ENOG4105C6Z Gluconate UA75_03795 ENOG4105C01 Dihydroxy-acid dehydratase UA75_03805 ENOG4107RE3 peptidase, S41 UA75_03830 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) UA75_03885 ENOG4105C7R Atpase associated with various cellular activities aaa_3 UA75_03900 ENOG4105CEP NADH dehydrogenase UA75_03940 ENOG4105CHU acetyl-coa acetyltransferase UA75_03965 ENOG4107HP6 Transcriptional regulator UA75_03970 ENOG4105E4C Lytic transglycosylase catalytic UA75_03990 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component UA75_03995 ENOG4105DRS transport system, permease UA75_04010 ENOG4105CXK mandelate racemase muconate lactonizing UA75_04075 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein UA75_04085 ENOG4105C7B Threonine dehydratase UA75_04105 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase UA75_04115 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) UA75_04125 ENOG4105T1M mycothiol conjugate amidase mca UA75_04135 ENOG4105DXX methyltransferase UA75_04140 ENOG4107S1Q Phosphatase UA75_04170 ENOG4105C7Z Conserved Protein UA75_04195 ENOG4108IAB Phoh family UA75_04205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA75_04215 ENOG4107VXM glycerophosphoryl diester phosphodiesterase UA75_04220 ENOG4105C9Q fumarate hydratase class II UA75_04225 ENOG4105CAY ferredoxin--nadp reductase UA75_04270 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) UA75_04280 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) UA75_04300 ENOG4105EYH Exonuclease UA75_04310 ENOG4105C3G gtp-binding protein UA75_04365 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family UA75_04370 ENOG410842T Pterin carbinolamine dehydratase UA75_04380 ENOG4105E0C molybdate abc transporter UA75_04385 ENOG4108UCS ABC, transporter UA75_04440 ENOG4105CJ1 ABC, transporter UA75_04450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family UA75_04455 ENOG4105E0F Histidine kinase UA75_04485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_04495 ENOG4108JQ7 (ABC) transporter UA75_04500 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) UA75_04510 ENOG4108Z4U Ferredoxin UA75_04520 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) UA75_04535 ENOG4107R4C succinyl-diaminopimelate desuccinylase UA75_04555 ENOG4105CS1 NAD(P)H quinone oxidoreductase UA75_04560 ENOG4108URH decarboxylase UA75_04565 ENOG4105EEI dihydropteroate synthase UA75_04650 ENOG4108UKI Enoyl-CoA hydratase UA75_04655 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein UA75_04665 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) UA75_04670 ENOG4105DDW LysR family Transcriptional regulator UA75_04675 ENOG4105D94 Major Facilitator Superfamily UA75_04680 ENOG4107QPH glycogen) synthase UA75_04685 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) UA75_04690 ENOG4107ZBN O-methyltransferase UA75_04695 ENOG4105DU6 RNA polymerase UA75_04705 ENOG4105C0H protease UA75_04710 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) UA75_04725 ENOG4105CI0 Citrate lyase UA75_04775 ENOG4105D7N magnesium and cobalt transport protein CorA UA75_04795 ENOG4105DB7 PHP domain protein UA75_04820 ENOG4105C1J atp-dependent rna helicase UA75_04840 ENOG4106HB6 Alpha beta hydrolase UA75_04885 ENOG4105C4R Atp-dependent dna helicase UA75_04905 ENOG4107SVH Potassium channel protein UA75_04930 ENOG4105C1V Peptidase, M16 UA75_04955 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA75_05005 ENOG41063PX domain protein UA75_05015 ENOG4105DJZ UPF0182 protein UA75_05035 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) UA75_05040 ENOG4105CAK Cell division ATP-binding protein ftsE UA75_05045 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) UA75_05050 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) UA75_05075 ENOG41080HT Transcriptional regulator, arsr family UA75_05080 ENOG4107T5V SNARE associated Golgi UA75_05095 ENOG4105CGH 5'-nucleotidase UA75_05100 ENOG4105CQ7 ATP-dependent helicase UA75_05105 ENOG4107RGD Major Facilitator superfamily UA75_05125 ENOG4108RWN rrna methyltransferase UA75_05135 ENOG4105BZ1 (ABC) transporter UA75_05140 ENOG4108JJ8 (ABC) transporter UA75_05145 ENOG4105CEY Amp-dependent synthetase and ligase UA75_05175 ENOG4105CEY Amp-dependent synthetase and ligase UA75_05185 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) UA75_05210 ENOG4105CEY Amp-dependent synthetase and ligase UA75_05220 ENOG4105CEY Amp-dependent synthetase and ligase UA75_05235 ENOG4105C37 (CBS) domain UA75_05240 ENOG4108M15 ABC transporter UA75_05250 ENOG4105BZU Histidine kinase UA75_05255 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_05260 ENOG4105CHJ isochorismatase hydrolase UA75_05265 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_05285 ENOG4105KVH Transcriptional regulator UA75_05315 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA75_05320 ENOG4106JDR secreted UA75_05325 ENOG4105ENE Histidine kinase UA75_05330 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_05340 ENOG4105PDP Short chain dehydrogenase UA75_05420 ENOG4108M15 ABC transporter UA75_05440 ENOG4105C57 major facilitator superfamily UA75_05450 ENOG41060BG Tetr family transcriptional regulator UA75_05500 ENOG4108PSK reductase UA75_05515 ENOG4105E1F short-chain dehydrogenase reductase UA75_05530 ENOG4106NZI LysR family Transcriptional regulator UA75_05535 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA75_05545 ENOG4105DWT malate dehydrogenase (quinone) UA75_05550 ENOG4105DIA mandelate racemase muconate lactonizing UA75_05600 ENOG4105BZN citrate synthase UA75_05620 ENOG4105JN3 extra-cytoplasmic solute receptor family protein UA75_05625 ENOG4107258 Transcriptional regulator UA75_05630 ENOG4105JSC dimethylmenaquinone methyltransferase UA75_05635 ENOG4108JQ1 Dehydrogenase UA75_05640 ENOG4105D9P serine threonine protein kinase UA75_05670 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase UA75_05685 ENOG41087PP glycosyltransferase MGT family UA75_05715 ENOG4105CHR reductase UA75_05725 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) UA75_05730 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) UA75_05735 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) UA75_05750 ENOG4105D74 hydrolase UA75_05760 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) UA75_05785 ENOG4105CJ1 ABC, transporter UA75_05790 ENOG41090VJ ABC-2 type transporter UA75_05810 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_05870 ENOG4105VPX protein, conserved in bacteria UA75_05895 ENOG4108UW5 maltose o-acetyltransferase UA75_05905 ENOG4107T6F Xaa-Pro aminopeptidase UA75_06040 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily UA75_06045 ENOG4108K01 transcriptional regulator UA75_06070 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_06075 ENOG4105BZU Histidine kinase UA75_06090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA75_06095 ENOG4107R34 abc transporter permease protein UA75_06110 ENOG4107YPT transcriptional regulator UA75_06155 ENOG4105EAC phosphoserine phosphatase UA75_06170 ENOG4107ZYJ bioY protein UA75_06175 ENOG4108RWI nicotinamidase UA75_06185 ENOG4105CB2 alcohol dehydrogenase UA75_06195 ENOG4107RKP Nicotinate phosphoribosyltransferase UA75_06200 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) UA75_06210 ENOG4105KXX peptidase s58 dmpa UA75_06240 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) UA75_06250 ENOG4105D7N magnesium and cobalt transport protein CorA UA75_06255 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) UA75_06260 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) UA75_06275 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) UA75_06280 ENOG4108D32 Methyltransferase UA75_06360 ENOG4105DKW ABC transporter UA75_06370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA75_06375 ENOG4105EVB acetyltransferase UA75_06400 ENOG4108KQJ Type 11 methyltransferase UA75_06410 ENOG410905P Pyridoxamine 5-phosphate UA75_06440 ENOG4105C10 Electron transfer flavoprotein UA75_06450 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) UA75_06515 ENOG4105H3G oxidoreductase UA75_06585 ENOG4105VQD rieske 2fe-2S domain-containing protein UA75_06590 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region UA75_06600 ENOG4105DVW rieske (2Fe-2S) UA75_06610 ENOG41065HY 1,4-beta-cellobiosidase UA75_06655 ENOG4106A3M Cytochrome p-450 UA75_06670 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) UA75_06685 ENOG4105CEY Amp-dependent synthetase and ligase UA75_06700 ENOG4107AQZ Membrane UA75_06715 ENOG4108594 Permease of the drug metabolite transporter UA75_06720 ENOG4105XYF acetyltransferase UA75_06775 ENOG4107WAU Protein tyrosine phosphatase UA75_06780 ENOG4105CIR epoxide hydrolase UA75_06805 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr UA75_06865 ENOG4108URH decarboxylase UA75_06870 ENOG4105C2C drug resistance transporter, Bcr CflA UA75_06905 ENOG4105D82 Glutamate dehydrogenase UA75_06910 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) UA75_06915 ENOG4105CPN adenine deaminase UA75_06925 ENOG4105PGM cation diffusion facilitator family transporter UA75_06930 ENOG4108KPJ rna polymerase sigma factor UA75_06955 ENOG4105C75 arginyL-tRNA synthetase UA75_06960 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) UA75_06965 ENOG4105D6E homoserine dehydrogenase UA75_06970 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) UA75_06975 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) UA75_06980 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) UA75_06980 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) UA75_06990 ENOG4105VFB Binds the 23S rRNA (By similarity) UA75_06995 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) UA75_07000 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) UA75_07015 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) UA75_07020 ENOG4105ESV Glycosyl transferase, family 4 UA75_07030 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) UA75_07040 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) UA75_07045 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) UA75_07050 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) UA75_07055 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) UA75_07060 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) UA75_07070 ENOG4105NAF rna polymerase sigma factor UA75_07075 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) UA75_07090 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) UA75_07095 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) UA75_07120 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA75_07125 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) UA75_07150 ENOG4105CMT Dihydroxyacetone kinase UA75_07160 ENOG4105VDH Dihydroxyacetone kinase UA75_07170 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 UA75_07180 ENOG4108ZVT methylmalonyl-coA epimerase UA75_07190 ENOG4105CHU acetyl-coa acetyltransferase UA75_07210 ENOG4105EYF MMPL domain protein UA75_07215 ENOG41067TZ transcriptional regulator, MarR family UA75_07225 ENOG4105D5P Methylmalonyl-coA mutase UA75_07250 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) UA75_07255 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) UA75_07270 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) UA75_07320 ENOG4105FKQ transcriptional regulator UA75_07340 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component UA75_07370 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_07385 ENOG4105MHT Transcriptional regulator, ARSR family UA75_07440 ENOG4105BZU Histidine kinase UA75_07445 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_07465 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) UA75_07480 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) UA75_07485 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) UA75_07490 ENOG4105CG3 alpha amylase, catalytic region UA75_07495 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) UA75_07510 ENOG4105CPC Aldo Keto reductase UA75_07525 ENOG4105DTD Dehydrogenase UA75_07570 ENOG4107R7Y intracellular protease Pfpi family UA75_07595 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) UA75_07600 ENOG4105EBR Carboxylesterase UA75_07640 ENOG4105CIG ABC transporter UA75_07700 ENOG4105DEN Luciferase family UA75_07735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr UA75_07750 ENOG4108KDT Molybdate metabolism regulator UA75_07765 ENOG4106F60 Histidine kinase UA75_07770 ENOG4105F44 Two component transcriptional regulator, winged helix family UA75_07775 ENOG4106JDR secreted UA75_07850 ENOG4105C7I Dehydrogenase UA75_07865 ENOG4105CG3 alpha amylase, catalytic region UA75_07875 ENOG4105D8X mechanosensitive ion channel UA75_07920 ENOG4109057 UA75_07930 ENOG4105MC2 DSBA oxidoreductase UA75_08000 ENOG4107QRI Phosphoketolase UA75_08015 ENOG4108RZE Tetr family transcriptional regulator UA75_08045 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation UA75_08050 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UA75_08055 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UA75_08060 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) UA75_08080 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) UA75_08105 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) UA75_08110 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase UA75_08120 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) UA75_08130 ENOG4105HAC ABC-2 type transporter UA75_08135 ENOG4105HAC ABC-2 type transporter UA75_08145 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) UA75_08150 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA75_08160 ENOG4105C03 ribonuclease UA75_08160 ENOG4105C03 ribonuclease UA75_08185 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) UA75_08190 ENOG4105K46 50S ribosomal protein l27 UA75_08195 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control UA75_08200 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) UA75_08210 ENOG4105C9U ATP-dependent DNA helicase RecQ UA75_08215 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) UA75_08230 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) UA75_08235 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) UA75_08245 ENOG4108TZC UA75_08250 ENOG4105EPR degv family UA75_08255 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein UA75_08270 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) UA75_08280 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) UA75_08295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) UA75_08330 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) UA75_08335 ENOG4105CEY Amp-dependent synthetase and ligase UA75_08350 ENOG4108RVA ribokinase UA75_08355 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) UA75_08385 ENOG4105C2J ABC transporter UA75_08390 ENOG4108HWW ABC transporter UA75_08395 ENOG4105E2R ROK family UA75_08405 ENOG4105CYX Short-chain dehydrogenase reductase Sdr UA75_08415 ENOG4105DFK Polyphosphate glucokinase UA75_08440 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) UA75_08465 ENOG4107VEG TrkA-N domain protein UA75_08470 ENOG4105C0X amino acid UA75_08475 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) UA75_08480 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) UA75_08485 ENOG4105F44 Two component transcriptional regulator, winged helix family UA75_08490 ENOG4106F60 Histidine kinase UA75_08505 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) UA75_08510 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) UA75_08515 ENOG4105KC9 Modulates RecA activity (By similarity) UA75_08525 ENOG4108UHU Aldolase UA75_08530 ENOG4105C01 Dihydroxy-acid dehydratase UA75_08545 ENOG4105DRP amino acid AbC transporter UA75_08550 ENOG4105E5Q amino acid AbC transporter UA75_08560 ENOG4105CDA abc transporter atp-binding protein UA75_08565 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) UA75_08575 ENOG4105C99 atpase involved in dna repair UA75_08585 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) UA75_08590 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) UA75_08600 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) UA75_08610 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) UA75_08620 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) UA75_08625 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UA75_08660 ENOG41073TP transcriptional regulator UA75_08675 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) UA75_08680 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) UA75_08690 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA75_08700 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) UA75_08720 ENOG4105DGU Histone deacetylase UA75_08740 ENOG4105BZU Histidine kinase UA75_08745 ENOG4108KXV response regulator UA75_08755 ENOG4105C6Z Gluconate UA75_08760 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family UA75_08795 ENOG4105K5M 30s ribosomal protein S16 UA75_08805 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) UA75_08810 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) UA75_08815 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) UA75_08820 ENOG4107QYR Signal peptidase i UA75_08825 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) UA75_08845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA75_08850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_08860 ENOG4108JQ7 (ABC) transporter UA75_08865 ENOG4105CNT hydrolase family 2 UA75_08870 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) UA75_08875 ENOG41080R2 UPF0102 protein UA75_08880 ENOG4105C0P Mg chelatase subunit ChlI UA75_08890 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UA75_08895 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) UA75_08910 ENOG4105CE9 30S ribosomal protein S2 UA75_08915 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) UA75_08920 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) UA75_08925 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) UA75_08935 ENOG41089UC methyltransferase, type 11 UA75_08940 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs UA75_08955 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UA75_08965 ENOG4105F38 ABC transporter, permease UA75_08970 ENOG4105D38 putrescine abc transporter UA75_08975 ENOG4105Y3U Transglycosylase-associated protein UA75_08980 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) UA75_08990 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) UA75_09010 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) UA75_09035 ENOG4105DJ2 Major Facilitator Superfamily UA75_09055 ENOG4108V1U phospholipid-binding protein UA75_09065 ENOG4105BZU Histidine kinase UA75_09070 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_09100 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap UA75_09135 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) UA75_09140 ENOG4105C1J atp-dependent rna helicase UA75_09150 ENOG4107XFJ UPF0246 protein UA75_09160 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) UA75_09170 ENOG4105DEN Luciferase family UA75_09200 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) UA75_09225 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) UA75_09230 ENOG41061TZ Short-chain dehydrogenase reductase Sdr UA75_09310 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) UA75_09335 ENOG4107QZF nitrite reductase NADPH large subunit UA75_09340 ENOG4107QZF nitrite reductase NADPH large subunit UA75_09345 ENOG4105DQQ Major facilitator superfamily MFS_1 UA75_09350 ENOG4108IFG nitrite reductase, (NAD(P)H) UA75_09355 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) UA75_09360 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) UA75_09370 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) UA75_09375 ENOG4105C1V Peptidase, M16 UA75_09380 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) UA75_09405 ENOG4108JJA ABC, transporter UA75_09435 ENOG4105T0Z Conserved Protein UA75_09450 ENOG4105E4C Lytic transglycosylase catalytic UA75_09455 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) UA75_09460 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA75_09465 ENOG4105CN5 Metallo-Beta-Lactamase UA75_09480 ENOG4107QZI cell division protein FtsK UA75_09500 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) UA75_09510 ENOG4108I62 cina-like protein UA75_09515 ENOG4105WBV Transcriptional regulator UA75_09535 ENOG4105C2W permease UA75_09540 ENOG4107SKI cobyrinic Acid a,c-diamide synthase UA75_09565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 UA75_09570 ENOG4108V6E Cell division protein mraZ UA75_09575 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) UA75_09585 ENOG4105CJN penicillin-binding protein UA75_09600 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) UA75_09605 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) UA75_09620 ENOG4105DFU Cell wall formation (By similarity) UA75_09625 ENOG4105ME9 cell division protein FtsQ UA75_09630 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone UA75_09640 ENOG4107R7A Allophanate hydrolase subunit 2 UA75_09650 ENOG4105E7W lamb ycsf family protein UA75_09655 ENOG4105CMG Carbohydrate kinase UA75_09670 ENOG4105DFA alanine racemase domain protein UA75_09675 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) UA75_09685 ENOG4107VQS DivIVA family UA75_09690 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) UA75_09720 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) UA75_09745 ENOG4105CHR reductase UA75_09755 ENOG4106A3M Cytochrome p-450 UA75_09760 ENOG4106A3M Cytochrome p-450 UA75_09765 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) UA75_09770 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) UA75_09780 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) UA75_09800 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) UA75_09805 ENOG4108IYU L-aspartate oxidase UA75_09845 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_09855 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) UA75_09860 ENOG4105CIH Imidazole acetol-phosphate transaminase UA75_09885 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase UA75_09895 ENOG4105ECC imidazole-glycerol-phosphate dehydratase UA75_09905 ENOG4108Z4X TRANSCRIPTIONal UA75_09910 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) UA75_09920 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase UA75_09935 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) UA75_09945 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase UA75_10000 ENOG4108X07 Tetr family transcriptional regulator UA75_10015 ENOG4105DK0 Indole-3-glycerol phosphate synthase UA75_10020 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) UA75_10025 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) UA75_10035 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) UA75_10040 ENOG4105CAT Cytidine monophosphate kinase UA75_10050 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) UA75_10070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA75_10075 ENOG4105JHE Major Facilitator Superfamily UA75_10080 ENOG4105CZE histidine utilization repressor UA75_10085 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) UA75_10095 ENOG4105N14 lysine exporter protein LysE YggA UA75_10100 ENOG4105J0Q Transcriptional regulator UA75_10140 ENOG4105DIA mandelate racemase muconate lactonizing UA75_10145 ENOG4105ERH Fumarylacetoacetate hydrolase UA75_10175 ENOG4105EQK -acetyltransferase UA75_10215 ENOG4107XZC Restriction modification system DNA (Specificity UA75_10225 ENOG4105D9P serine threonine protein kinase UA75_10240 ENOG4105CHP RNA polymerase UA75_10245 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) UA75_10260 ENOG4105KVH Transcriptional regulator UA75_10265 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase UA75_10275 ENOG4105E4C Lytic transglycosylase catalytic UA75_10280 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) UA75_10300 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) UA75_10320 ENOG4105CAT Cytidine monophosphate kinase UA75_10355 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA75_10370 ENOG4105C1B dTDP-glucose 4-6-dehydratase UA75_10380 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase UA75_10385 ENOG4105DKP glycosyl transferase, family 9 UA75_10390 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) UA75_10395 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) UA75_10400 ENOG4105CHR reductase UA75_10410 ENOG4105C6Y Udp-glucose 6-dehydrogenase UA75_10425 ENOG4105C31 Tryptophanyl-tRNA synthetase UA75_10430 ENOG4105WCJ ec 1.1.1.193 UA75_10435 ENOG4107TXC Transcriptional regulator UA75_10440 ENOG4105CHH sulfate transporter UA75_10455 ENOG4107SET aldo keto reductase UA75_10470 ENOG4106T9R serine protease UA75_10490 ENOG4108YV4 Universal stress protein UA75_10505 ENOG4105C9U ATP-dependent DNA helicase RecQ UA75_10525 ENOG4105D22 carbon starvation protein UA75_10535 ENOG4105D0U Arsenite-activated ATPase (ArsA) UA75_10540 ENOG4105S6R Iron-hydroxamate transporter permease subunit UA75_10550 ENOG4105E0A ABC, transporter UA75_10575 ENOG4105FDP GntR family transcriptional regulator UA75_10635 ENOG4105BZU Histidine kinase UA75_10655 ENOG4107RHI Cytosine-specific methyltransferase UA75_10695 ENOG4105C32 Amino acid ABC transporter (Permease) UA75_10700 ENOG4105CF8 branched-chain amino acid ABC transporter, permease UA75_10705 ENOG4105C0Z ABC transporter UA75_10710 ENOG4108IV0 ABC, transporter UA75_10715 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) UA75_10725 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase UA75_10745 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) UA75_10750 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) UA75_10755 ENOG4105EXC Acyl-transferase UA75_10760 ENOG4105EXC Acyl-transferase UA75_10765 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) UA75_10795 ENOG4105CJ1 ABC, transporter UA75_10805 ENOG4105CI2 imidazolone-5-propionate hydrolase UA75_10810 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA75_10840 ENOG4105C22 threonyL-tRNA synthetase UA75_10855 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase UA75_10860 ENOG4105E2K Glycosyl transferase (Group 1 UA75_10865 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) UA75_10880 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) UA75_10895 ENOG4108IMY Transcriptional regulator UA75_10910 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) UA75_10915 ENOG4105CDY transcriptional regulatory protein UA75_10935 ENOG4106A3M Cytochrome p-450 UA75_10940 ENOG4105DTD Dehydrogenase UA75_10955 ENOG4107STQ Multicopper oxidase UA75_10965 ENOG4105DUX Transporter UA75_10970 ENOG4107EXU Short-chain dehydrogenase reductase Sdr UA75_10980 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase UA75_11060 ENOG4105CAQ asparagine synthetase UA75_11065 ENOG4108K6T Protein of unknown function (DUF1205) UA75_11070 ENOG4105CHR reductase UA75_11085 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein UA75_11095 ENOG4105CZS beta-ketoacyl synthase UA75_11115 ENOG4105CHR reductase UA75_11130 ENOG4108DUX Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) UA75_11135 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein UA75_11140 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase UA75_11160 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily UA75_11165 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) UA75_11170 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) UA75_11175 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) UA75_11185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) UA75_11190 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) UA75_11195 ENOG4107VMB Beta-lactamase domain protein UA75_11245 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) UA75_11250 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) UA75_11325 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap UA75_11340 ENOG4105KVH Transcriptional regulator UA75_11345 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UA75_11350 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) UA75_11355 ENOG4107SIG periplasmic solute binding protein UA75_11360 ENOG4105DIK (ABC) transporter UA75_11365 ENOG4105CC5 ABC transporter UA75_11370 ENOG4107RBD ABC, transporter UA75_11375 ENOG4107STQ Multicopper oxidase UA75_11400 ENOG4108S4H thioesterase Superfamily protein UA75_11405 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) UA75_11420 ENOG4105F76 Sarcosine oxidase UA75_11470 ENOG4108UW8 fha domain-containing protein UA75_11490 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor UA75_11495 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) UA75_11515 ENOG4105DUX Transporter UA75_11520 ENOG4108Q5F Tetr family transcriptional regulator UA75_11525 ENOG4105D1K glutamate--cysteine ligase UA75_11530 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process UA75_11535 ENOG4108V75 Glutamine amidotransferase UA75_11540 ENOG41067HS methyltransferase UA75_11560 ENOG4107QM5 aconitate hydratase UA75_11575 ENOG4105ZXU NLP P60 protein UA75_11580 ENOG4107RSM transcriptional regulator UA75_11585 ENOG4105FDR Membrane UA75_11595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 UA75_11605 ENOG4107QVM von Willebrand factor, type A UA75_11610 ENOG4105CHR reductase UA75_11620 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH UA75_11625 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) UA75_11630 ENOG410651K Teichoic acid biosynthesis protein C UA75_11640 ENOG4108UF8 UA75_11670 ENOG4105C26 Dehydrogenase UA75_11695 ENOG4105DV0 amidase (EC 3.5.1.4 UA75_11720 ENOG41073TP transcriptional regulator UA75_11730 ENOG4108JPW Aminotransferase UA75_11740 ENOG4105CT1 (ABC) transporter UA75_11765 ENOG4108UW8 fha domain-containing protein UA75_11770 ENOG4105D9P serine threonine protein kinase UA75_11785 ENOG4105CHU acetyl-coa acetyltransferase UA75_11790 ENOG4105EE5 Membrane protein terC UA75_11805 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase UA75_11810 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA75_11860 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) UA75_11925 ENOG410769Z extracellular solute-binding protein family 1 UA75_11935 ENOG4105JXH GntR family transcriptional regulator UA75_11940 ENOG4105CX8 fg-gap repeat protein UA75_12010 ENOG4105CPP Dehydrogenase, E1 component UA75_12015 ENOG4108JYK Dehydrogenase UA75_12040 ENOG4105CQ7 ATP-dependent helicase UA75_12060 ENOG4108VBZ doxx family UA75_12075 ENOG4105C9M aspartyl-trna synthetase UA75_12085 ENOG41082W1 Cupin 2, conserved barrel domain protein UA75_12130 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) UA75_12145 ENOG4105E2X shikimate dehydrogenase UA75_12185 ENOG4105FDP GntR family transcriptional regulator UA75_12195 ENOG4105C5Y PTS System UA75_12205 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase UA75_12210 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) UA75_12220 ENOG4105D49 3-dehydroquinate synthase UA75_12225 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) UA75_12230 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase UA75_12240 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) UA75_12245 ENOG4105DC7 peptidase M24 UA75_12250 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) UA75_12255 ENOG410803B Involved in the transcription termination process (By similarity) UA75_12265 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) UA75_12270 ENOG4105CXT aspartate transcarbamylase UA75_12285 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain UA75_12295 ENOG4105SKN orotidine 5''-phosphate decarboxylase UA75_12310 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) UA75_12320 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP UA75_12355 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) UA75_12360 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UA75_12375 ENOG4108J5H Homocysteine s-methyltransferase UA75_12390 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) UA75_12395 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) UA75_12410 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) UA75_12415 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) UA75_12425 ENOG4105CIE May be required for sporulation (By similarity) UA75_12430 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase UA75_12435 ENOG4105BZA Phosphoglycerate kinase UA75_12440 ENOG4105CP7 Triose-phosphate isomerase UA75_12475 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) UA75_12490 ENOG4107QP8 phosphohexose isomerase UA75_12495 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) UA75_12505 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) UA75_12550 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein UA75_12570 ENOG410600Z Regulatory protein MarR UA75_12585 ENOG4105CJ1 ABC, transporter UA75_12590 ENOG4107JC6 Membrane UA75_12615 ENOG4105C3K feS assembly ATPase SufC UA75_12625 ENOG4108UNV SUF system FeS assembly protein, NifU family UA75_12630 ENOG4105VG1 fes assembly suf system protein UA75_12650 ENOG4107XTP (EAL) domain protein UA75_12670 ENOG4105CHR reductase UA75_12680 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) UA75_12700 ENOG4105C5H ABC transporter UA75_12710 ENOG4105CGU Enoyl-CoA hydratase UA75_12725 ENOG4105KVH Transcriptional regulator UA75_12755 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) UA75_12785 ENOG4105CPQ Dehydrogenase UA75_12820 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) UA75_12830 ENOG4105EWU Squalene--hopene cyclase UA75_12835 ENOG4105EAH synthase UA75_12845 ENOG4105EBR Carboxylesterase UA75_12860 ENOG4105CJA serine threonine protein kinase UA75_12880 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase UA75_12885 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) UA75_12890 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) UA75_12895 ENOG41061CK Antibiotic biosynthesis monooxygenase UA75_12935 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) UA75_12950 ENOG4105PTV Nudix Hydrolase UA75_12955 ENOG4105E5F proteasome UA75_12960 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) UA75_12965 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) UA75_12970 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) UA75_12985 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) UA75_12995 ENOG4107TMB Transcriptional regulator UA75_13025 ENOG4105HHS UPF0256 protein UA75_13045 ENOG4105J0Q Transcriptional regulator UA75_13065 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) UA75_13070 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA75_13080 ENOG4105FS0 cytoplasmic membrane protein UA75_13085 ENOG4105EFZ amidohydrolase UA75_13095 ENOG4107NHD transcriptional regulator UA75_13115 ENOG4105CPC Aldo Keto reductase UA75_13150 ENOG4105BZ1 (ABC) transporter UA75_13160 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain UA75_13205 ENOG4105D9P serine threonine protein kinase UA75_13220 ENOG4105DQE DNA ligase UA75_13225 ENOG4105DQE DNA ligase UA75_13230 ENOG41080XP Cbs domain UA75_13235 ENOG4105CH6 catalase UA75_13245 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) UA75_13255 ENOG4105C09 Bile acid UA75_13265 ENOG4105F0K SARP family transcriptional regulator UA75_13270 ENOG4105CJA serine threonine protein kinase UA75_13290 ENOG4107ZR7 Membrane UA75_13305 ENOG4105DQ5 transport system permease protein UA75_13310 ENOG4105TVJ transport system, permease UA75_13315 ENOG4105E0A ABC, transporter UA75_13320 ENOG4105BZ1 (ABC) transporter UA75_13325 ENOG4105BZ1 (ABC) transporter UA75_13340 ENOG41082A2 Alpha beta hydrolase UA75_13345 ENOG4105EKC UA75_13380 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) UA75_13385 ENOG4108IG5 Transcriptional regulator UA75_13390 ENOG4105FCA ABC transporter periplasmic-binding protein YphF UA75_13395 ENOG4108F37 ATP-binding component of a transport system UA75_13400 ENOG4105CNN ABC, transporter UA75_13405 ENOG4105CPQ Dehydrogenase UA75_13420 ENOG4105EMF GntR family transcriptional regulator UA75_13425 ENOG4105CXK mandelate racemase muconate lactonizing UA75_13430 ENOG4108UHU Aldolase UA75_13435 ENOG4105D7K pfkb domain protein UA75_13460 ENOG4108IMY Transcriptional regulator UA75_13500 ENOG4107RSM transcriptional regulator UA75_13520 ENOG4107U9B transcriptional regulator UA75_13540 ENOG41080S5 HTH_DTXR UA75_13570 ENOG4105CHR reductase UA75_13575 ENOG4105EMU Dehydrogenase UA75_13585 ENOG4108IV0 ABC, transporter UA75_13590 ENOG4105C0Z ABC transporter UA75_13595 ENOG4105C32 Amino acid ABC transporter (Permease) UA75_13610 ENOG4105C1G acyl-Coa dehydrogenase UA75_13615 ENOG4105CEY Amp-dependent synthetase and ligase UA75_13630 ENOG4105G9B Transcriptional regulator UA75_13645 ENOG4105CHU acetyl-coa acetyltransferase UA75_13650 ENOG4105C1G acyl-Coa dehydrogenase UA75_13675 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) UA75_13680 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) UA75_13685 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) UA75_13690 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) UA75_13715 ENOG4108JQ9 ABC transporter UA75_13735 ENOG4105CHR reductase UA75_13740 ENOG4107RSM transcriptional regulator UA75_13745 ENOG4105YIP Tetr family transcriptional regulator UA75_13770 ENOG4105GWZ Roadblock lc7 family protein UA75_13785 ENOG4105NAF rna polymerase sigma factor UA75_13860 ENOG4105FB9 CRISPR-associated protein UA75_13880 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) UA75_13885 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) UA75_13920 ENOG410905P Pyridoxamine 5-phosphate UA75_13945 ENOG4108IY8 ABC, transporter UA75_13955 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component UA75_13990 ENOG4108Z4X TRANSCRIPTIONal UA75_14010 ENOG4105C0R drug resistance transporter emrb qaca subfamily UA75_14015 ENOG4108ME1 Peptidase M55 D-aminopeptidase UA75_14025 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA75_14030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_14050 ENOG4105VEQ Cold shock protein UA75_14060 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) UA75_14070 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A UA75_14120 ENOG4105EET magnesium chelatase UA75_14140 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_14180 ENOG4105C8N cysteinyl-tRNA synthetase UA75_14195 ENOG410814C multidrug resistance protein UA75_14205 ENOG4105C3R Methionine synthase UA75_14210 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) UA75_14220 ENOG4105BZN citrate synthase UA75_14235 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) UA75_14240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) UA75_14250 ENOG4108ZHR arsR family transcriptional regulator UA75_14260 ENOG4105C57 major facilitator superfamily UA75_14265 ENOG4105BZ1 (ABC) transporter UA75_14280 ENOG410769Z extracellular solute-binding protein family 1 UA75_14295 ENOG4105FB2 class II Aldolase UA75_14300 ENOG4105G63 Type III effector Hrp-dependent UA75_14310 ENOG4105C6Z Gluconate UA75_14315 ENOG4105MVE transcriptional regulator UA75_14330 ENOG4105J7D transcriptional regulator UA75_14340 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b UA75_14460 ENOG4105CDU Replicative dna helicase UA75_14875 ENOG4105F27 Major Facilitator UA75_14890 ENOG4105CVK Glutamate decarboxylase UA75_14920 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 UA75_14945 ENOG4105QE3 oxidoreductase UA75_14960 ENOG4105C6N Formate acetyltransferase UA75_14970 ENOG4105C26 Dehydrogenase UA75_14995 ENOG4105G6Z alkaline phosphatase UA75_15005 ENOG4107RTD sua5 ycio yrdc ywlc family protein UA75_15010 ENOG4105E0A ABC, transporter UA75_15015 ENOG4105TVJ transport system, permease UA75_15020 ENOG4105DQ5 transport system permease protein UA75_15045 ENOG4105C57 major facilitator superfamily UA75_15055 ENOG4105YIP Tetr family transcriptional regulator UA75_15065 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family UA75_15070 ENOG4105C5H ABC transporter UA75_15075 ENOG4105CN8 Transcriptional regulator UA75_15090 ENOG4108UZX fmn reductase UA75_15100 ENOG4105CPQ Dehydrogenase UA75_15110 ENOG4105FBA Phospholipase Carboxylesterase UA75_15115 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase UA75_15120 ENOG4105CS1 NAD(P)H quinone oxidoreductase UA75_15125 ENOG41090MY MarR family Transcriptional regulator UA75_15130 ENOG4105F32 YngK protein UA75_15205 ENOG4105D74 hydrolase UA75_15210 ENOG4105DHI Methyltransferase UA75_15220 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein UA75_15240 ENOG4108V9W transcriptional regulatory protein UA75_15270 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) UA75_15280 ENOG4107W53 thymidine kinase UA75_15285 ENOG4105DEU major facilitator superfamily UA75_15300 ENOG4105BZU Histidine kinase UA75_15315 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UA75_15360 ENOG4105K6H D-cysteine desulfhydrase UA75_15400 ENOG4105KNA -acetyltransferase UA75_15405 ENOG4105ECR NmrA family UA75_15415 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase UA75_15430 ENOG4105BZ1 (ABC) transporter UA75_15435 ENOG4105BZ1 (ABC) transporter UA75_15460 ENOG4105C3M thioredoxin reductase UA75_15470 ENOG4105C0D helicase UA75_15490 ENOG4105V75 Transcriptional regulator UA75_15505 ENOG4105CSU acyl-Coa dehydrogenase UA75_15515 ENOG4108V8F Transcriptional regulator, MarR family UA75_15520 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase UA75_15535 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) UA75_15540 ENOG4107S9F NmrA family UA75_15585 ENOG4105ECR NmrA family UA75_15590 ENOG4105KVH Transcriptional regulator UA75_15600 ENOG4108IG5 Transcriptional regulator UA75_15615 ENOG4107SCK Monooxygenase UA75_15620 ENOG4105DDN Pentapeptide repeat-containing protein UA75_15625 ENOG4105YIP Tetr family transcriptional regulator UA75_15635 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr UA75_15665 ENOG4105E4C Lytic transglycosylase catalytic UA75_15680 ENOG4108R86 Transcriptional regulator UA75_15745 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) UA75_15750 ENOG4105EBR Carboxylesterase UA75_15760 ENOG4105CHP RNA polymerase UA75_15765 ENOG4105GRZ Ycii-related protein UA75_15775 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase UA75_15790 ENOG4108IG5 Transcriptional regulator UA75_15805 ENOG4108KTG Membrane protein, drug metabolite transporter UA75_15815 ENOG41065SU Two-component system sensor kinase UA75_15820 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_15845 ENOG4105GRZ Ycii-related protein UA75_15850 ENOG4105CHP RNA polymerase UA75_15855 ENOG4105C57 major facilitator superfamily UA75_15905 ENOG4105GRZ Ycii-related protein UA75_15920 ENOG4108IND Tetr family transcriptional regulator UA75_15925 ENOG4105DND Transcriptional regulator UA75_15930 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase UA75_15960 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) UA75_15970 ENOG4105C57 major facilitator superfamily UA75_15975 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) UA75_15990 ENOG4105CPC Aldo Keto reductase UA75_16000 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA75_16005 ENOG4105M2Z protein tyrosine serine phosphatase UA75_16025 ENOG4105C0D helicase UA75_16035 ENOG4105NAE bifunctional deaminase-reductase domain protein UA75_16040 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) UA75_16045 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UA75_16090 ENOG4105ECQ AraC Family Transcriptional Regulator UA75_16095 ENOG4108X0B nad(p)h dehydrogenase (quinone) UA75_16100 ENOG4107SET aldo keto reductase UA75_16125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase UA75_16145 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) UA75_16150 ENOG4105DYW oxidoreductase UA75_16170 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) UA75_16240 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA75_16320 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 UA75_16355 ENOG4106A3M Cytochrome p-450 UA75_16360 ENOG4107S9R deoxycytidine triphosphate deaminase UA75_16375 ENOG4105CRK lysyL-tRNA synthetase UA75_16395 ENOG4105DK7 lysyl-tRNA synthetase UA75_16420 ENOG4107TB6 phosphoglycerate mutase UA75_16440 ENOG4105K64 Glycosyl transferase, family 2 UA75_16500 ENOG4105BZU Histidine kinase UA75_16595 ENOG4105GMT ATPase associated with various cellular activities aaa_5 UA75_16640 ENOG4105F9F transposase UA75_16645 ENOG4105CM2 brancheD-chain amino acid aminotransferase UA75_16660 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) UA75_16690 ENOG4105Q56 cytochrome P450 UA75_16700 ENOG4105CEY Amp-dependent synthetase and ligase UA75_16720 ENOG4105CEY Amp-dependent synthetase and ligase UA75_16755 ENOG4105CEY Amp-dependent synthetase and ligase UA75_16760 ENOG4106YKD Cytochrome p-450 UA75_16790 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase UA75_16805 ENOG4108JA1 polyketide synthase UA75_16850 ENOG4105CPC Aldo Keto reductase UA75_16855 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase UA75_17170 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) UA75_17195 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) UA75_17210 ENOG410849S phosphocarrier protein (HPr) UA75_17215 ENOG4105DM4 PTS System UA75_17220 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN UA75_17225 ENOG4105DE4 1-phosphofructokinase UA75_17230 ENOG4105E98 transcriptional regulator DeoR family UA75_17240 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) UA75_17275 ENOG4105CHR reductase UA75_17280 ENOG4105H3G oxidoreductase UA75_17320 ENOG4105C57 major facilitator superfamily UA75_17375 ENOG4105EBR Carboxylesterase UA75_17380 ENOG4108W6C Dehydrogenase UA75_17400 ENOG4105QV4 Tryptophan halogenase UA75_17410 ENOG4105CJ1 ABC, transporter UA75_17430 ENOG4105K5B UPF0225 protein UA75_17435 ENOG4105CIG ABC transporter UA75_17475 ENOG4105FKQ transcriptional regulator UA75_17480 ENOG4107VFM Dehydrogenase UA75_17505 ENOG4105CEY Amp-dependent synthetase and ligase UA75_17510 ENOG4105CEY Amp-dependent synthetase and ligase UA75_17515 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) UA75_17525 ENOG4105CTU Proline racemase UA75_17550 ENOG4105G3Z GntR family transcriptional regulator UA75_17570 ENOG4105C3U ABC transporter UA75_17580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_17585 ENOG4105DEF Extracellular solute-binding protein, family 5 UA75_17595 ENOG4108EUP Glycosyl hydrolase family 62 UA75_17630 ENOG4108YZG isomerase UA75_17640 ENOG4105CDH Citrulline--aspartate ligase UA75_17680 ENOG4105CIF Ornithine Cyclodeaminase UA75_17700 ENOG41088SP formiminoglutamate hydrolase UA75_17715 ENOG4105E0A ABC, transporter UA75_17720 ENOG4105EHG Permease protein UA75_17760 ENOG4105CX8 fg-gap repeat protein UA75_17790 ENOG4105EEM helicase UA75_17820 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase UA75_17835 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_17860 ENOG4105C0R drug resistance transporter emrb qaca subfamily UA75_17950 ENOG4106NZI LysR family Transcriptional regulator UA75_17970 ENOG41061TZ Short-chain dehydrogenase reductase Sdr UA75_17980 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) UA75_17995 ENOG4105C6Y Udp-glucose 6-dehydrogenase UA75_18000 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) UA75_18005 ENOG4106YKD Cytochrome p-450 UA75_18010 ENOG4108DMH HTH_ARAC UA75_18030 ENOG41082YX Transcriptional regulator, arsr family UA75_18050 ENOG4108VQT Alpha beta hydrolase fold protein UA75_18055 ENOG4105C57 major facilitator superfamily UA75_18075 ENOG4105CMR udp-glucose 4-epimerase UA75_18090 ENOG4106YKD Cytochrome p-450 UA75_18170 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) UA75_18175 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) UA75_18205 ENOG4105D1F ATP-binding protein UA75_18210 ENOG4105DWV Homoserine O-trans-acetylase UA75_18215 ENOG4108X07 Tetr family transcriptional regulator UA75_18225 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) UA75_18230 ENOG4108KPJ rna polymerase sigma factor UA75_18290 ENOG4105CJ1 ABC, transporter UA75_18300 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_18310 ENOG4105XEA Tetr family transcriptional regulator UA75_18325 ENOG4107SYN Glycosyl hydrolases family 43 UA75_18335 ENOG4105ETE Transcriptional regulator (LacI family UA75_18350 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component UA75_18360 ENOG4105ETE Transcriptional regulator (LacI family UA75_18380 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone UA75_18385 ENOG4108UZX fmn reductase UA75_18400 ENOG4107TXC Transcriptional regulator UA75_18405 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) UA75_18425 ENOG4105CUC YeeE YedE family protein UA75_18445 ENOG4105F0K SARP family transcriptional regulator UA75_18475 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein UA75_18480 ENOG4105EWK phytoene UA75_18545 ENOG4107Z3H Transcriptional regulator, TetR family UA75_18550 ENOG4107R13 MMPL domain protein UA75_18555 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase UA75_18560 ENOG4107SWG transcriptional regulator MERR family UA75_18570 ENOG4105CG3 alpha amylase, catalytic region UA75_18615 ENOG4105BZU Histidine kinase UA75_18650 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) UA75_18655 ENOG4105ETE Transcriptional regulator (LacI family UA75_18705 ENOG4105CKI cobalamin synthesis protein UA75_18710 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_18725 ENOG4105CNN ABC, transporter UA75_18730 ENOG4105C2J ABC transporter UA75_18740 ENOG4105JXH GntR family transcriptional regulator UA75_18745 ENOG4105H9W Short-chain dehydrogenase reductase Sdr UA75_18775 ENOG4105E2A Dehydrogenase UA75_18800 ENOG41062B0 ABC transporter, permease UA75_18805 ENOG4107R9N ABC transporter UA75_18810 ENOG4105C2J ABC transporter UA75_18815 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator UA75_18820 ENOG4105CNT hydrolase family 2 UA75_18825 ENOG4105E98 transcriptional regulator DeoR family UA75_18850 ENOG4107S5I aldo keto reductase UA75_18910 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_19050 ENOG4105CHP RNA polymerase UA75_19075 ENOG4107SQU synthase UA75_19085 ENOG41068W2 Cytochrome p-450 UA75_19145 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) UA75_19165 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) UA75_19210 ENOG4105XN3 extracellular solute-binding protein family 1 UA75_19220 ENOG4105DRS transport system, permease UA75_19230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA75_19235 ENOG4105C5I Dehydrogenase UA75_19250 ENOG4107HP6 Transcriptional regulator UA75_19255 ENOG4107FKK extracellular solute-binding protein family 1 UA75_19260 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component UA75_19270 ENOG4105CXK mandelate racemase muconate lactonizing UA75_19280 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) UA75_19290 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) UA75_19300 ENOG4107RSM transcriptional regulator UA75_19305 ENOG4107AQZ Membrane UA75_19310 ENOG4105ETE Transcriptional regulator (LacI family UA75_19350 ENOG4105DR3 abc transporter permease protein UA75_19355 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component UA75_19365 ENOG4107QK4 glycoside hydrolase, family 3 domain protein UA75_19380 ENOG4108VW9 Membrane UA75_19385 ENOG410905P Pyridoxamine 5-phosphate UA75_19415 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase UA75_19420 ENOG4105MHT Transcriptional regulator, ARSR family UA75_19430 ENOG41080RH Thioredoxin UA75_19435 ENOG4105RHY Pfam:UPF0157 UA75_19440 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) UA75_19460 ENOG4105C38 Glycyl-tRNA synthetase beta subunit UA75_19475 ENOG4105E0A ABC, transporter UA75_19480 ENOG4105EHG Permease protein UA75_19495 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving UA75_19500 ENOG4105CGD Nad-dependent epimerase dehydratase UA75_19505 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA75_19555 ENOG4107SCK Monooxygenase UA75_19590 ENOG4108I5C dEAD DEAH box helicase UA75_19600 ENOG4105C0D helicase UA75_19625 ENOG4108W6C Dehydrogenase UA75_19640 ENOG4105SC1 monovalent cation H antiporter subunit E UA75_19645 ENOG4108JPZ Monovalent cation H antiporter subunit D UA75_19650 ENOG4105MKQ Monovalent cation H antiporter subunit C UA75_19655 ENOG4105D65 subunit l UA75_19670 ENOG4105CIG ABC transporter UA75_19675 ENOG4107ZYR domain protein UA75_19680 ENOG4105CZN Potassium uptake protein UA75_19685 ENOG4106F60 Histidine kinase UA75_19690 ENOG4105F44 Two component transcriptional regulator, winged helix family UA75_19700 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) UA75_19745 ENOG4105EYF MMPL domain protein UA75_19810 ENOG4105C01 Dihydroxy-acid dehydratase UA75_19845 ENOG4105KPY Small multidrug resistance protein UA75_19850 ENOG4105F6U Short-chain dehydrogenase reductase Sdr UA75_19855 ENOG4108IND Tetr family transcriptional regulator UA75_19875 ENOG4105TVJ transport system, permease UA75_19880 ENOG4105DQ5 transport system permease protein UA75_19905 ENOG4105Y3U Transglycosylase-associated protein UA75_19920 ENOG4105KKX ATPase associated with various cellular activities aaa_5 UA75_19925 ENOG4105DEG Vwa containing coxe family protein UA75_19950 ENOG4105C57 major facilitator superfamily UA75_19970 ENOG41082BM Transcriptional regulator, arsr family UA75_19975 ENOG4105CAY ferredoxin--nadp reductase UA75_20005 ENOG4105CPQ Dehydrogenase UA75_20010 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component UA75_20015 ENOG4105D56 permease protein UA75_20025 ENOG4108UHU Aldolase UA75_20055 ENOG4105C22 threonyL-tRNA synthetase UA75_20060 ENOG4105F1N DNA alkylation repair UA75_20095 ENOG4105CC5 ABC transporter UA75_20100 ENOG4105E0A ABC, transporter UA75_20105 ENOG4105C7K acetolactate synthase UA75_20125 ENOG4105EPH radical SAM domain protein UA75_20135 ENOG4106A3M Cytochrome p-450 UA75_20155 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) UA75_20185 ENOG41082BM Transcriptional regulator, arsr family UA75_20190 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase UA75_20290 ENOG4105CQB FAD linked oxidase domain protein UA75_20305 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_20325 ENOG4105DE4 1-phosphofructokinase UA75_20340 ENOG4107QNK )-transporter UA75_20345 ENOG4105E2D ec 3.2.1.52 UA75_20375 ENOG4108KDT Molybdate metabolism regulator UA75_20385 ENOG4108KDT Molybdate metabolism regulator UA75_20390 ENOG4105KKX ATPase associated with various cellular activities aaa_5 UA75_20395 ENOG4105RD5 UA75_20400 ENOG4105DEG Vwa containing coxe family protein UA75_20405 ENOG410903U zinc ion binding UA75_20410 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_20425 ENOG4108MXF Alpha Beta Hydrolase UA75_20460 ENOG41073TP transcriptional regulator UA75_20470 ENOG4105CMT Dihydroxyacetone kinase UA75_20475 ENOG4107YVI ribose 5-phosphate isomerase UA75_20480 ENOG4105CP7 Triose-phosphate isomerase UA75_20485 ENOG4108KFM Xylose Isomerase Domain-Containing protein UA75_20490 ENOG4106J7G oxidoreductase UA75_20500 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) UA75_20510 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) UA75_20520 ENOG4107U2T alpha beta UA75_20525 ENOG4108IJ9 (ABC) transporter UA75_20590 ENOG4105FS7 Transcriptional regulator UA75_20595 ENOG4105CIR epoxide hydrolase UA75_20640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_20645 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) UA75_20675 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) UA75_20775 ENOG4105D9P serine threonine protein kinase UA75_20820 ENOG4106A3M Cytochrome p-450 UA75_20830 ENOG4105TVJ transport system, permease UA75_20835 ENOG4105DQ5 transport system permease protein UA75_20840 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein UA75_20845 ENOG4108478 ec 3.2.1.18 UA75_20860 ENOG4108IND Tetr family transcriptional regulator UA75_20885 ENOG4108V15 phosphotransferase enzyme family UA75_20930 ENOG4105VEQ Cold shock protein UA75_20935 ENOG4105W1N transcriptional regulator UA75_20950 ENOG4105K6H D-cysteine desulfhydrase UA75_20965 ENOG4105GZI Transcriptional regulator UA75_20970 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA75_20985 ENOG4105EFA 4-hydroxyphenylacetate UA75_20990 ENOG4105KME endoribonuclease L-psp UA75_21000 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit UA75_21005 ENOG4105RE0 Asp Glu hydantoin racemase UA75_21015 ENOG4105CG6 trap dicarboxylate transporter dctm subunit UA75_21020 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA75_21045 ENOG4105D9P serine threonine protein kinase UA75_21080 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) UA75_21115 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) UA75_21125 ENOG4105EX0 alpha-galactosidase UA75_21135 ENOG4105CPQ Dehydrogenase UA75_21140 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) UA75_21150 ENOG41080R8 Conserved Protein UA75_21155 ENOG4105M6F mutator MutT protein UA75_21170 ENOG4108KXV response regulator UA75_21175 ENOG41065SU Two-component system sensor kinase UA75_21185 ENOG4105EXC Acyl-transferase UA75_21195 ENOG4107TTA Xylose isomerase domain protein TIM barrel UA75_21205 ENOG4105CNN ABC, transporter UA75_21210 ENOG4105CNN ABC, transporter UA75_21215 ENOG4105C2J ABC transporter UA75_21290 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) UA75_21295 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) UA75_21335 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA75_21350 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) UA75_21415 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_21495 ENOG41088YS Glycosyl transferase (Group 1 UA75_21505 ENOG4108YUY UA75_21515 ENOG4105CHR reductase UA75_21520 ENOG41064E2 Xylose isomerase-like TIM barrel UA75_21525 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 UA75_21530 ENOG4108KK4 3-dehydroquinate synthase UA75_21540 ENOG4105CYP glycoside hydrolase, family UA75_21555 ENOG4105DRS transport system, permease UA75_21570 ENOG4105ETE Transcriptional regulator (LacI family UA75_21580 ENOG4105DAA L-lactate UA75_21590 ENOG4105CHR reductase UA75_21595 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) UA75_21610 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) UA75_21615 ENOG4108BT0 50S ribosomal protein L32 UA75_21620 ENOG4105NRA 50s ribosomal protein l31 type b UA75_21635 ENOG4105W0E 50S ribosomal protein L33 UA75_21640 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) UA75_21645 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) UA75_21650 ENOG4105CV8 reductase UA75_21660 ENOG4105BZF Glycosyl transferase (Group 1 UA75_21665 ENOG4108RZE Tetr family transcriptional regulator UA75_21670 ENOG4105CJ1 ABC, transporter UA75_21680 ENOG4105WX6 Membrane UA75_21690 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase UA75_21710 ENOG4105DR5 peptidase UA75_21740 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) UA75_21745 ENOG4105BZ4 penicillin-binding protein UA75_21755 ENOG4105CHH sulfate transporter UA75_21775 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) UA75_21780 ENOG4105DY8 decarboxylase UA75_21790 ENOG4105C29 acyl-CoA thioesterase UA75_21805 ENOG4105IIU Aminopeptidase UA75_21820 ENOG4105CBC glutamate synthase UA75_21825 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) UA75_21830 ENOG4105EHG Permease protein UA75_21835 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) UA75_21855 ENOG4105CPP Dehydrogenase, E1 component UA75_21930 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) UA75_21935 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) UA75_21970 ENOG4108ZGX Histidine kinase UA75_21975 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_21995 ENOG4108YZ4 nudix hydrolase UA75_22000 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) UA75_22020 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) UA75_22035 ENOG4105DSU hydrolase UA75_22065 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) UA75_22070 ENOG4108VX5 3-methyladenine DNA glycosylase UA75_22075 ENOG4105CH7 arginosuccinase UA75_22085 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) UA75_22090 ENOG4105DBV ornithine carbamoyltransferase UA75_22100 ENOG4105CAS nag kinase UA75_22105 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) UA75_22110 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase UA75_22130 ENOG4105D63 family UPF0324 UA75_22135 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) UA75_22140 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) UA75_22155 ENOG4108RWN rrna methyltransferase UA75_22160 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) UA75_22165 ENOG41084BS 50S ribosomal protein L35 UA75_22210 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) UA75_22235 ENOG4108K8S endonuclease I UA75_22280 ENOG4105BZW Glycerate kinase UA75_22295 ENOG4105BZU Histidine kinase UA75_22320 ENOG4107EEY synthase UA75_22355 ENOG4105EMU Dehydrogenase UA75_22365 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone UA75_22410 ENOG41082BM Transcriptional regulator, arsr family UA75_22435 ENOG4108TKH Nitroreductase UA75_22455 ENOG4105K6V RNA polymerase UA75_22460 ENOG4105KF0 sporulation and cell division protein, SsgA UA75_22535 ENOG4105CPC Aldo Keto reductase UA75_22545 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) UA75_22570 ENOG4108RFG Tetr family transcriptional regulator UA75_22575 ENOG4106UW1 Major Facilitator superfamily UA75_22590 ENOG4105DDC Oxidoreductase domain protein UA75_22610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_22615 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component UA75_22625 ENOG4105CK5 oxidoreductase UA75_22640 ENOG4105ETE Transcriptional regulator (LacI family UA75_22645 ENOG4105DEI Mannitol dehydrogenase UA75_22650 ENOG4105CTX dehydratase UA75_22655 ENOG4105CE4 GlcNAc 6-P deacetylase UA75_22660 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) UA75_22665 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA75_22670 ENOG4108X07 Tetr family transcriptional regulator UA75_22695 ENOG4105E0A ABC, transporter UA75_22710 ENOG4105EHG Permease protein UA75_22740 ENOG4105EMF GntR family transcriptional regulator UA75_22755 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component UA75_22760 ENOG4105DRS transport system, permease UA75_22775 ENOG4108KEZ Dehydrogenase UA75_22780 ENOG4105CHR reductase UA75_22785 ENOG41082A2 Alpha beta hydrolase UA75_22810 ENOG4105DJB Major Facilitator Superfamily UA75_22820 ENOG4105EBM Alpha Beta Hydrolase Fold protein UA75_22865 ENOG4108762 serine threonine protein kinase UA75_22870 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) UA75_22885 ENOG41088T4 Helicase IV UA75_22910 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_22915 ENOG4108ZGX Histidine kinase UA75_22925 ENOG4107STQ Multicopper oxidase UA75_22940 ENOG4106A3M Cytochrome p-450 UA75_22945 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) UA75_22960 ENOG4105UNS Pfam:DUF419 UA75_22965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit UA75_22990 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) UA75_23000 ENOG4105DEF Extracellular solute-binding protein, family 5 UA75_23010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_23020 ENOG4108JQ7 (ABC) transporter UA75_23035 ENOG4105KVH Transcriptional regulator UA75_23040 ENOG41069M3 Transcriptional regulator UA75_23045 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_23095 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) UA75_23145 ENOG4105C5I Dehydrogenase UA75_23155 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase UA75_23160 ENOG4106NZI LysR family Transcriptional regulator UA75_23165 ENOG4105DEF Extracellular solute-binding protein, family 5 UA75_23175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component UA75_23185 ENOG4108JQ7 (ABC) transporter UA75_23200 ENOG4105MHT Transcriptional regulator, ARSR family UA75_23210 ENOG4107TCW O-succinylbenzoate synthase UA75_23220 ENOG4105C5I Dehydrogenase UA75_23225 ENOG4105EQX glucarate dehydratase UA75_23230 ENOG4105KME endoribonuclease L-psp UA75_23235 ENOG4105J4Q Transcriptional regulator UA75_23245 ENOG4108UHU Aldolase UA75_23250 ENOG4105CWC Acetylornithine deacetylase UA75_23260 ENOG4108I5G Major Facilitator superfamily UA75_23285 ENOG4108FN7 Aldo keto reductase UA75_23295 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA75_23365 ENOG4107QNK )-transporter UA75_23385 ENOG4105C57 major facilitator superfamily UA75_23390 ENOG4105C57 major facilitator superfamily UA75_23410 ENOG4105DKT Transcriptional regulator UA75_23415 ENOG4105CPQ Dehydrogenase UA75_23460 ENOG4108TAG Histidine kinase UA75_23465 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) UA75_23485 ENOG4106A3M Cytochrome p-450 UA75_23490 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) UA75_23495 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_23505 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) UA75_23515 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) UA75_23590 ENOG4108VWQ crispr-associated protein UA75_23595 ENOG41060M0 Crispr-associated protein, cse4 family UA75_23630 ENOG4105CX8 fg-gap repeat protein UA75_23635 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) UA75_23695 ENOG41060M0 Crispr-associated protein, cse4 family UA75_23700 ENOG4108VWQ crispr-associated protein UA75_23725 ENOG4105DWV Homoserine O-trans-acetylase UA75_23735 ENOG4105BZM domain protein UA75_23760 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid UA75_23785 ENOG4105BZU Histidine kinase UA75_23790 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_23795 ENOG4105C4M (Ubiquinol oxidase) subunit I UA75_23805 ENOG4108JJ9 ABC, transporter UA75_23810 ENOG4108JJ8 (ABC) transporter UA75_23835 ENOG4105CX8 fg-gap repeat protein UA75_23890 ENOG4105Q26 Siderophore-interacting protein UA75_23945 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA75_23950 ENOG41082AN stage II sporulation protein UA75_23990 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) UA75_24000 ENOG4108Z0Z intracellular protease Pfpi family UA75_24055 ENOG4107R33 ppx gppa phosphatase UA75_24065 ENOG4105ETE Transcriptional regulator (LacI family UA75_24085 ENOG41060NJ transcriptional regulator UA75_24135 ENOG4105C8Y Acetylornithine aminotransferase UA75_24140 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) UA75_24190 ENOG4105CUT histidyl-tRNA synthetase UA75_24205 ENOG4105E0X reductase UA75_24215 ENOG4107JTW chlorite dismutase UA75_24220 ENOG4105C1Q protoporphyrinogen oxidase UA75_24225 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) UA75_24235 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_24250 ENOG4105CHU acetyl-coa acetyltransferase UA75_24255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase UA75_24270 ENOG4105DIA mandelate racemase muconate lactonizing UA75_24290 ENOG410769Z extracellular solute-binding protein family 1 UA75_24295 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component UA75_24300 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component UA75_24315 ENOG4108J20 pectate lyase UA75_24320 ENOG4108J20 pectate lyase UA75_24325 ENOG4105E4I Glycoside hydrolase family 28 UA75_24340 ENOG410769Z extracellular solute-binding protein family 1 UA75_24345 ENOG4105DET Rhamnulokinase UA75_24360 ENOG4105C9F isomerase UA75_24370 ENOG4105ETE Transcriptional regulator (LacI family UA75_24375 ENOG4105C4C beta-galactosidase UA75_24380 ENOG4105DDC Oxidoreductase domain protein UA75_24420 ENOG4108E16 pectate lyase UA75_24425 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) UA75_24445 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein UA75_24455 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_24475 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component UA75_24485 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component UA75_24495 ENOG4108I5U Uridine phosphorylase UA75_24500 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) UA75_24525 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) UA75_24530 ENOG4105CD3 dihydroorotase UA75_24565 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) UA75_24610 ENOG4107V2S Transcriptional regulator UA75_24620 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) UA75_24625 ENOG4105ETE Transcriptional regulator (LacI family UA75_24665 ENOG4105ETE Transcriptional regulator (LacI family UA75_24670 ENOG4105ETE Transcriptional regulator (LacI family UA75_24685 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component UA75_24690 ENOG4105I1K ABC transporter UA75_24725 ENOG4105DRS transport system, permease UA75_24735 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) UA75_24830 ENOG4107S1E Beta-lactamase UA75_24840 ENOG4105DHF Membrane UA75_24855 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_24860 ENOG4105BZU Histidine kinase UA75_24870 ENOG4108M15 ABC transporter UA75_24880 ENOG4105ECQ AraC Family Transcriptional Regulator UA75_24890 ENOG4105DTD Dehydrogenase UA75_24900 ENOG4105CIR epoxide hydrolase UA75_24920 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) UA75_24930 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) UA75_24935 ENOG4108KPJ rna polymerase sigma factor UA75_24945 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein UA75_24955 ENOG4105EC3 peptidase S51, dipeptidase E UA75_24960 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) UA75_24995 ENOG4108PJD permease UA75_25005 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) UA75_25030 ENOG4105CZV ABC transporter UA75_25035 ENOG4105FDP GntR family transcriptional regulator UA75_25040 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) UA75_25045 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) UA75_25070 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) UA75_25080 ENOG4107YU2 histidine triad (hIT) protein UA75_25090 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) UA75_25095 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) UA75_25105 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) UA75_25115 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) UA75_25135 ENOG4108IY8 ABC, transporter UA75_25165 ENOG41067XF inhibitor UA75_25175 ENOG4105CB2 alcohol dehydrogenase UA75_25190 ENOG4107QWG 2-Nitropropane dioxygenase UA75_25205 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA75_25210 ENOG4107QRT dEAD DEAH box helicase UA75_25260 ENOG41090CE integral membrane protein UA75_25285 ENOG4105DZ6 Band 7 protein UA75_25305 ENOG4108QXE glycerophosphoryl diester phosphodiesterase UA75_25345 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase UA75_25360 ENOG4105CNA YD repeat protein UA75_25405 ENOG4105E9Q Acyl-transferase UA75_25420 ENOG4105DKQ ROK family UA75_25455 ENOG4105JNK Glycosyl transferase (Group 1 UA75_25465 ENOG4105K4H Nlp p60 protein UA75_25495 ENOG4107UDY cytochrome C UA75_25500 ENOG4105CCU oxidase (Subunit III) UA75_25515 ENOG4107S1N anthranilate phosphoribosyltransferase UA75_25520 ENOG4108ZRS Part of cytochrome c oxidase, its function is UA75_25525 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) UA75_25595 ENOG4105CPC Aldo Keto reductase UA75_25605 ENOG4108YZT Adenosylcobinamide kinase UA75_25610 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) UA75_25615 ENOG41080Z7 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) UA75_25620 ENOG4105CM2 brancheD-chain amino acid aminotransferase UA75_25635 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) UA75_25660 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) UA75_25675 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) UA75_25690 ENOG4105C5F glutamine synthetase UA75_25705 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) UA75_25710 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UA75_25740 ENOG4105C5F glutamine synthetase UA75_25750 ENOG4105C4K Nad synthetase UA75_25760 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) UA75_25765 ENOG4105CHF Glutathione S-transferase UA75_25795 ENOG4105ZXU NLP P60 protein UA75_25840 ENOG4105CVJ phosphoglycerate mutase UA75_25905 ENOG4105DQ4 alcohol dehydrogenase UA75_25930 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) UA75_25945 ENOG4105CJW magnesium transporter UA75_26005 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) UA75_26010 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) UA75_26035 ENOG4107QN2 dihydrolipoyl dehydrogenase UA75_26080 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) UA75_26085 ENOG4105CK7 Sodium proline symporter UA75_26120 ENOG4108375 Acylphosphatase (EC 3.6.1.7) UA75_26125 ENOG4105K4I Scp-like extracellular UA75_26145 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) UA75_26150 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) UA75_26155 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) UA75_26165 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) UA75_26170 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) UA75_26175 ENOG41084BZ 50S ribosomal protein L32 UA75_26195 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) UA75_26200 ENOG4106H78 methyltransferase UA75_26205 ENOG4105CHR reductase UA75_26215 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) UA75_26230 ENOG4105RHY Pfam:UPF0157 UA75_26275 ENOG4105CB5 ATP-dependent DNA helicase recG UA75_26285 ENOG4105VB9 50S ribosomal protein l28 UA75_26295 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) UA75_26315 ENOG4108Z0R Transferase UA75_26340 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family UA75_26355 ENOG4105DA5 (ABC) transporter UA75_26370 ENOG4105CPF Cell wall formation (By similarity) UA75_26375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA75_26390 ENOG4105C28 cystathionine UA75_26395 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase UA75_26405 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) UA75_26425 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) UA75_26430 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) UA75_26455 ENOG4105PAD Hydrolase UA75_26460 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) UA75_26470 ENOG4105ERH Fumarylacetoacetate hydrolase UA75_26490 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) UA75_26495 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) UA75_26500 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin UA75_26515 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase UA75_26520 ENOG4108ZP8 Acetolactate synthase small subunit UA75_26535 ENOG4105C01 Dihydroxy-acid dehydratase UA75_26560 ENOG4108762 serine threonine protein kinase UA75_26570 ENOG4108VGI doxx family UA75_26575 ENOG4108VGI doxx family UA75_26605 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) UA75_26620 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) UA75_26625 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) UA75_26630 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) UA75_26670 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) UA75_26690 ENOG4105C7B Threonine dehydratase UA75_26695 ENOG4105FDF Could be involved in DNA repair (By similarity) UA75_26730 ENOG4105C57 major facilitator superfamily UA75_26745 ENOG4105C1G acyl-Coa dehydrogenase UA75_26755 ENOG4107QX3 carboxylase UA75_26805 ENOG4105VG5 Membrane UA75_26820 ENOG4105EBM Alpha Beta Hydrolase Fold protein UA75_26825 ENOG4108K8K Transcriptional regulator UA75_26830 ENOG4105DCF alanine dehydrogenase UA75_26860 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 UA75_26885 ENOG4105CI2 imidazolone-5-propionate hydrolase UA75_26910 ENOG4105CGP Urocanate hydratase UA75_26915 ENOG4105C84 Histidine ammonia-lyase UA75_26945 ENOG4105E90 ABC transporter UA75_26950 ENOG4105E90 ABC transporter UA75_26955 ENOG4108IJ8 ABC transporter UA75_26965 ENOG4105BZU Histidine kinase UA75_26980 ENOG4108ZM9 phosphoglycerate mutase UA75_27000 ENOG4105CBD Diacylglycerol kinase UA75_27020 ENOG4105WMN AntiSigma factor UA75_27030 ENOG4108Z66 YbaK ebsC protein UA75_27040 ENOG4108RAV Conserved protein UA75_27050 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase UA75_27070 ENOG4105C26 Dehydrogenase UA75_27085 ENOG4105C2N RNA methyltransferase TrmH family group 3 UA75_27090 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 UA75_27100 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving UA75_27110 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea UA75_27120 ENOG4108MKR lipoprotein lpqb UA75_27125 ENOG4105BZU Histidine kinase UA75_27130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family UA75_27145 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) UA75_27155 ENOG4105CUB amino acid UA75_27160 ENOG4105EIP mannose-6-phosphate isomerase UA75_27170 ENOG4105W49 UPF0434 protein UA75_27190 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA75_27195 ENOG4107XZ0 Peptidase M50 UA75_27200 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase UA75_27205 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) UA75_27225 ENOG4105C6F GntR Family Transcriptional Regulator UA75_27245 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA75_27250 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA75_27265 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) UA75_27280 ENOG4107TB5 TRANSCRIPTIONal UA75_27285 ENOG4107TB5 TRANSCRIPTIONal UA75_27305 ENOG4105CJ1 ABC, transporter UA75_27315 ENOG4105D4B ABC, transporter UA75_27320 ENOG4105CNN ABC, transporter UA75_27325 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane UA75_27330 ENOG4105C2J ABC transporter UA75_27345 ENOG4105C8V SAICAR synthetase UA75_27355 ENOG4105E0Y RtcB Protein UA75_27390 ENOG4108S0S Nucleotidyl transferase UA75_27395 ENOG4105E0F Histidine kinase UA75_27400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family UA75_27405 ENOG4107TK4 histidinol-phosphate phosphatase UA75_27435 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase UA75_27455 ENOG4105D8K carboxyl transferase UA75_27470 ENOG4105GRZ Ycii-related protein UA75_27480 ENOG4105VT3 DNA binding domain protein, excisionase family UA75_27490 ENOG4105C4Y ABC transporter UA75_27500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) UA75_27505 ENOG4105C7F AcnD-accessory protein PrpF UA75_27510 ENOG4107R11 Transcriptional regulator UA75_27515 ENOG4107WR6 Maf-like protein UA75_27525 ENOG4105CK2 sodium dicarboxylate symporter UA75_27530 ENOG4108JIK carboxylase UA75_27560 ENOG4105C6V Glycerol-3-phosphate dehydrogenase UA75_27570 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) UA75_27610 ENOG4107RM1 amidohydrolase UA75_27660 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) UA75_27690 ENOG4105CNN ABC, transporter UA75_27695 ENOG4105C2J ABC transporter UA75_27705 ENOG4107S9F NmrA family UA75_27720 ENOG4105BZU Histidine kinase UA75_27725 ENOG4108M15 ABC transporter UA75_27735 ENOG4105E2R ROK family UA75_27745 ENOG4105W1N transcriptional regulator UA75_27775 ENOG4108JPZ Monovalent cation H antiporter subunit D UA75_27780 ENOG4105MKQ Monovalent cation H antiporter subunit C UA75_27790 ENOG4105D65 subunit l UA75_27795 ENOG4105D5P Methylmalonyl-coA mutase UA75_27800 ENOG4107TPY serine threonine protein kinase UA75_27810 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain UA75_27815 ENOG4105CPC Aldo Keto reductase UA75_27825 ENOG41086VY Fic/DOC family UA75_27845 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) UA75_27855 ENOG4107RZZ dna polymerase iii epsilon subunit UA75_27940 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) UA75_27945 ENOG4105C26 Dehydrogenase UA75_27950 ENOG4105C26 Dehydrogenase UA75_28000 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) UA75_28030 ENOG4108JQ9 ABC transporter UA75_28035 ENOG4105DIH basic membrane UA75_28065 ENOG4107H3J ribonuclease UA75_28085 ENOG4105CGK Exodeoxyribonuclease III UA75_28125 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) UA75_28140 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) UA75_28175 ENOG4105C0B DNA polymerase III (alpha subunit) UA75_28195 ENOG4105DC1 bifunctional purine biosynthesis protein purh UA75_28220 ENOG4105CMV Succinyl-CoA synthetase subunit beta UA75_28235 ENOG4105DR5 peptidase UA75_28240 ENOG41063SB peptidase UA75_28250 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_28330 ENOG4107TPY serine threonine protein kinase UA75_28335 ENOG4107RSM transcriptional regulator UA75_28340 ENOG4105FR1 rard protein UA75_28365 ENOG4105ETE Transcriptional regulator (LacI family UA75_28370 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UA75_28410 ENOG4107QVP Dehydrogenase UA75_28445 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) UA75_28450 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) UA75_28455 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) UA75_28460 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_28465 ENOG4105DGI Alkaline phosphatase UA75_28470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) UA75_28475 ENOG41080E2 ribosomal-protein-alanine acetyltransferase UA75_28485 ENOG4107R9S Malate synthase UA75_28490 ENOG41069M3 Transcriptional regulator UA75_28500 ENOG4108097 ATP-binding protein UA75_28510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) UA75_28520 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) UA75_28560 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) UA75_28565 ENOG4108UJD 30S ribosomal protein S9 UA75_28570 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) UA75_28590 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA75_28595 ENOG4105EC2 ftsk spoIIIe UA75_28605 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin UA75_28665 ENOG4105BZU Histidine kinase UA75_28710 ENOG4105EC2 ftsk spoIIIe UA75_28720 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) UA75_28725 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein UA75_28745 ENOG4108IUX (ABC) transporter UA75_28750 ENOG4105RHA ABC transporter, permease UA75_28755 ENOG4105CVP deoxyribo-dipyrimidine photolyase UA75_28770 ENOG4105CI2 imidazolone-5-propionate hydrolase UA75_28775 ENOG4107WI4 Aldose-1-epimerase UA75_28780 ENOG4105DVH amino acid UA75_28785 ENOG4105E8G Major facilitator Superfamily UA75_28790 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) UA75_28795 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) UA75_28825 ENOG4105BZ1 (ABC) transporter UA75_28835 ENOG4105FCS tRNA rRNA methyltransferase UA75_28850 ENOG4105E8G Major facilitator Superfamily UA75_28860 ENOG4105C7N Xanthine uracil vitamin C permease UA75_28885 ENOG4108N0W Major Facilitator superfamily UA75_28905 ENOG4105VEQ Cold shock protein UA75_28915 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) UA75_28925 ENOG4105JAB phenazine biosynthesis protein, phzf family UA75_28935 ENOG4105F4R Transcriptional regulator mode UA75_28940 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) UA75_28950 ENOG4105MS9 Resuscitation-promoting factor UA75_28995 ENOG4105GWZ Roadblock lc7 family protein UA75_29015 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component UA75_29030 ENOG4105CFI type iii restriction protein res subunit UA75_29055 ENOG4106N3A copper homeostasis protein cutc UA75_29080 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) UA75_29110 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) UA75_29145 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) UA75_29165 ENOG4106BRA Membrane UA75_29240 ENOG4105KVH Transcriptional regulator UA75_29255 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) UA75_29265 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) UA75_29275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA75_29280 ENOG4108VW9 Membrane UA75_29290 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase UA75_29295 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family UA75_29335 ENOG4105K64 Glycosyl transferase, family 2 UA75_29350 ENOG4105CMR udp-glucose 4-epimerase UA75_29370 ENOG4105D3Q Sugar transferase UA75_29400 ENOG4108KGH TRANSCRIPTIONal UA75_29410 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F UA75_29415 ENOG4105C1G acyl-Coa dehydrogenase UA75_29430 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) UA75_29455 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) UA75_29460 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 UA75_29530 ENOG4105CNU cell division protein FtsK UA75_29600 ENOG4105BZU Histidine kinase UA75_29615 ENOG4108UTW Plays a role in the regulation of phosphate uptake UA75_29625 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) UA75_29630 ENOG4105E2Z phosphate ABC transporter (Permease UA75_29645 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) UA75_29650 ENOG4107NHD transcriptional regulator UA75_29675 ENOG4105KHC sulfurtransferase UA75_29680 ENOG4105PKJ carbohydrate binding UA75_29685 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands UA75_29745 ENOG4105CXB phosphoribosylaminoimidazole synthetase UA75_29760 ENOG4105BZP glycoside hydrolase 15-related UA75_29765 ENOG4105BZU Histidine kinase UA75_29780 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii UA75_29785 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I UA75_29790 ENOG410839H phosphoribosylformylglycinamidine synthase UA75_29815 ENOG4105C83 adenylosuccinate lyase UA75_29825 ENOG4105NAF rna polymerase sigma factor UA75_29830 ENOG4107TXC Transcriptional regulator UA75_29845 ENOG4105KPY Small multidrug resistance protein UA75_29890 ENOG4105EEQ Na H antiporter UA75_29895 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis UA75_29960 ENOG4108RWP Major Facilitator Superfamily protein UA75_30015 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) UA75_30020 ENOG4105CE4 GlcNAc 6-P deacetylase UA75_30030 ENOG4105CQB FAD linked oxidase domain protein UA75_30040 ENOG4105WH1 Two component transcriptional regulator luxr family UA75_30050 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) UA75_30070 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) UA75_30075 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB UA75_30120 ENOG4105BZG amino acid carrier protein UA75_30125 ENOG4105C8P )-transporter UA75_30130 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit UA75_30140 ENOG4105PDP Short chain dehydrogenase UA75_30150 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) UA75_30195 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) UA75_30200 ENOG4108V0P LemA family UA75_30205 ENOG4105C2N RNA methyltransferase TrmH family group 3 UA75_30220 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) UA75_30230 ENOG4105KNI merR family transcriptional Regulator UA75_30235 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) UA75_30240 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ UA75_30245 ENOG4105CFG Acts as a chaperone (By similarity) UA75_30255 ENOG4105DF6 Fe-S oxidoreductase UA75_30260 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) UA75_30265 ENOG4105EHG Permease protein UA75_30290 ENOG4108PSK reductase UA75_30315 ENOG4105DHP deoxycytidine triphosphate deaminase UA75_30320 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 UA75_30340 ENOG4105CSU acyl-Coa dehydrogenase UA75_30370 ENOG4108RZE Tetr family transcriptional regulator UA75_30380 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) UA75_30415 ENOG4105CFC Transporter UA75_30425 ENOG4105CDA abc transporter atp-binding protein UA75_30430 ENOG4105E5Q amino acid AbC transporter UA75_30435 ENOG4107R0W ABC transporter UA75_30440 ENOG4105EAB amino acid AbC transporter UA75_30445 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) UA75_30455 ENOG4105CPP Dehydrogenase, E1 component UA75_30460 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 UA75_30475 ENOG4105EMU Dehydrogenase UA75_30515 ENOG4105BZ4 penicillin-binding protein UA75_30535 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) UA75_30540 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) UA75_30545 ENOG4107YH6 single-stranded DNA-binding protein UA75_30550 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) UA75_30555 ENOG4105K9Q Binds to the 23S rRNA (By similarity) UA75_30585 ENOG4106YKD Cytochrome p-450 UA75_30590 ENOG4108Z6Z Transcriptional regulator UA75_30600 ENOG4105VUF Transcriptional regulator UA75_30610 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) UA75_30615 ENOG4105F27 Major Facilitator UA75_30655 ENOG4105BZU Histidine kinase UA75_30675 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) UA75_30680 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) UA75_30685 ENOG4108RVA ribokinase UA75_30690 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator UA75_30695 ENOG4105CNN ABC, transporter UA75_30700 ENOG4105C2J ABC transporter UA75_30705 ENOG4105ETE Transcriptional regulator (LacI family UA75_30730 ENOG4105C8T Leucyl-tRNA synthetase UA75_30740 ENOG4108UJU UPF0301 protein UA75_30750 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate UA75_30770 ENOG4107QPV Serine Threonine protein kinase UA75_30785 ENOG4105C3M thioredoxin reductase UA75_30790 ENOG4105K63 Thioredoxin UA75_30795 ENOG4108E1C hydrolase UA75_30805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family UA75_30815 ENOG4105FA0 parb-like partition protein UA75_30820 ENOG4107QJE Chromosome Partitioning Protein UA75_30825 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) UA75_30830 ENOG4105CS9 pantothenic acid kinase UA75_30845 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) UA75_30850 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) UA75_30855 ENOG41084CH 50S ribosomal protein l34 UA75_30940 ENOG4105CDU Replicative dna helicase