locus-tag class description ACEE_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ACEE_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ACEE_00020 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ACEE_00025 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ACEE_00035 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ACEE_00040 ENOG4105ERU peptidase ACEE_00050 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ACEE_00055 ENOG4105VEJ Heat shock protein ACEE_00060 ENOG4107RK2 ADP-ribose diphosphatase NudE ACEE_00070 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ACEE_00075 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) ACEE_00080 ENOG4105D2S major facilitator superfamily ACEE_00090 ENOG4108TGC Acyltransferase ACEE_00095 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ACEE_00115 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ACEE_00125 ENOG4105DAY polysaccharide export protein ACEE_00160 ENOG4105CMR udp-glucose 4-epimerase ACEE_00165 ENOG4105EYM Major Facilitator superfamily ACEE_00195 ENOG4105ECP epimerase ACEE_00200 ENOG4105C0H protease ACEE_00205 ENOG4105DHJ ABC, transporter ACEE_00210 ENOG4105CY3 ABC transporter, permease ACEE_00215 ENOG4107PE3 Mammalian cell entry related domain protein ACEE_00220 ENOG4105E3I toluene tolerance ACEE_00230 ENOG4105VFK BolA family ACEE_00235 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ACEE_00250 ENOG4105C5H ABC transporter ACEE_00255 ENOG4107RZZ dna polymerase iii epsilon subunit ACEE_00275 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) ACEE_00280 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ACEE_00285 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ACEE_00290 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ACEE_00295 ENOG4105W49 UPF0434 protein ACEE_00335 ENOG41090FY type IV pilus biogenesis stability protein PilW ACEE_00340 ENOG4105BZM domain protein ACEE_00345 ENOG4105CEP NADH dehydrogenase ACEE_00350 ENOG4105GPY SprT protein ACEE_00355 ENOG41083KI ribonuclease, T2 ACEE_00360 ENOG4105D07 Signal peptide peptidase, SppA ACEE_00365 ENOG41069NU Nitroreductase ACEE_00370 ENOG4105E1F short-chain dehydrogenase reductase ACEE_00375 ENOG4105C59 p-type ATPase ACEE_00380 ENOG4105C59 p-type ATPase ACEE_00385 ENOG4108Z6Z Transcriptional regulator ACEE_00390 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ACEE_00400 ENOG4105C8U phosphate abc transporter ACEE_00405 ENOG4105E2Z phosphate ABC transporter (Permease ACEE_00415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACEE_00420 ENOG4105BZU Histidine kinase ACEE_00425 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACEE_00430 ENOG4105C8P )-transporter ACEE_00435 ENOG4105C8P )-transporter ACEE_00440 ENOG4105C8P )-transporter ACEE_00445 ENOG4105BZA Phosphoglycerate kinase ACEE_00450 ENOG4105D2N Aldolase ACEE_00470 ENOG4108TVJ Nitroreductase ACEE_00475 ENOG4108TEB UPF0114 protein ACEE_00480 ENOG4105DC8 reductase ACEE_00490 ENOG4105EYA deoxyribonuclease ACEE_00500 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ACEE_00505 ENOG4105EG2 ABC transporter, permease ACEE_00510 ENOG4105D56 permease protein ACEE_00515 ENOG4107FKK extracellular solute-binding protein family 1 ACEE_00520 ENOG4108IJ9 (ABC) transporter ACEE_00525 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) ACEE_00530 ENOG4107W52 maltose operon periplasmic protein ACEE_00535 ENOG41061ZR Transcriptional regulator ACEE_00540 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ACEE_00555 ENOG4105EAC phosphoserine phosphatase ACEE_00560 ENOG41062Z9 Membrane ACEE_00565 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ACEE_00570 ENOG4105CBX hi0933 family ACEE_00575 ENOG41090EX DsrE family ACEE_00580 ENOG4105C7N Xanthine uracil vitamin C permease ACEE_00585 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ACEE_00590 ENOG4108Z66 YbaK ebsC protein ACEE_00595 ENOG4105NNH LexA regulated protein ACEE_00600 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ACEE_00605 ENOG41090R7 Ferric uptake ACEE_00610 ENOG4105DY2 Paraquat-inducible protein b ACEE_00615 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ACEE_00620 ENOG4105BZ1 (ABC) transporter ACEE_00625 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 ACEE_00635 ENOG4106RHG Yeca family ACEE_00640 ENOG4105D9R oxidoreductase ACEE_00645 ENOG4107QN2 dihydrolipoyl dehydrogenase ACEE_00660 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) ACEE_00665 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ACEE_00675 ENOG4105N21 Membrane ACEE_00685 ENOG4105C12 Phosphoribosylglycinamide synthetase ACEE_00695 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) ACEE_00710 ENOG4105Z2P Protein of unknown function (DUF465) ACEE_00715 ENOG4105RHG ACEE_00720 ENOG4105D4X repressor ACEE_00725 ENOG4105DMQ Methyltransferase ACEE_00735 ENOG4105DDQ anthranilate synthase ACEE_00740 ENOG4105CRQ synthase (Component I) ACEE_00745 ENOG4105EZR dyp-type peroxidase family protein ACEE_00750 ENOG4107RTD sua5 ycio yrdc ywlc family protein ACEE_00755 ENOG4105FE9 pseudouridine synthase ACEE_00765 ENOG4105DZ2 Transcriptional regulator ACEE_00800 ENOG4107RAN Peptidase, M16 ACEE_00805 ENOG4105CQ0 ABC transporter ACEE_00810 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ACEE_00820 ENOG4105CDY transcriptional regulatory protein ACEE_00825 ENOG4108TIT dATP pyrophosphohydrolase ACEE_00850 ENOG4105DP9 ABC transporter ACEE_00855 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) ACEE_00860 ENOG4105DJ0 Poly(A) Polymerase ACEE_00865 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ACEE_00875 ENOG4107H52 Dicarboxylate transport ACEE_00885 ENOG4108UYE Lactoylglutathione lyase ACEE_00890 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) ACEE_00895 ENOG4105K3M )-transporter ACEE_00900 ENOG4105CSH Transporter ACEE_00910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ACEE_00915 ENOG4107T0K Adenylate cyclase ACEE_00920 ENOG4105CKD glutathione-regulated potassium-efflux system protein ACEE_00925 ENOG4105DA4 cytochrome c-type biogenesis protein ACEE_00930 ENOG4107QX9 Thiol disulfide interChange protein ACEE_00935 ENOG4108DMF Cytochrome C biogenesis protein ACEE_00940 ENOG4108W0S formate-dependent nitrite reductase complex ACEE_00945 ENOG4108ZPB UPF0306 protein ACEE_00950 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related ACEE_00960 ENOG4105CQC Prephenate dehydratase ACEE_00965 ENOG4105DGW oligopeptidase A ACEE_00970 ENOG4105UGU tonB-dependent Receptor ACEE_00975 ENOG4105F1A Pyruvate formate-lyase ACEE_00980 ENOG4105C6N Formate acetyltransferase ACEE_00985 ENOG4105TMB Formate nitrite transporter ACEE_00990 ENOG4105W39 Membrane ACEE_00995 ENOG4105D0M Protease HtpX homolog ACEE_01005 ENOG4105DWU Membrane ACEE_01010 ENOG4105E4F Isochorismate synthase ACEE_01015 ENOG4105CHM Aminotransferase ACEE_01020 ENOG4105DTR rard protein ACEE_01025 ENOG4105DTR rard protein ACEE_01030 ENOG4105C25 Primosomal protein n' ACEE_01035 ENOG41080C8 DUF218 domain ACEE_01045 ENOG4105D2T synthase ACEE_01060 ENOG4108MY6 biosynthesis protein ACEE_01065 ENOG4105P7J Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide ACEE_01070 ENOG41068D6 Glycosyltransferase ACEE_01080 ENOG4108RJ9 Glycosyl transferase, family 2 ACEE_01085 ENOG4108RYC glycosyltransferase ACEE_01090 ENOG4105E0X reductase ACEE_01100 ENOG4105D9N nucleoside ACEE_01110 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ACEE_01115 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ACEE_01125 ENOG4105C8Y Acetylornithine aminotransferase ACEE_01135 ENOG4108MVK Receptor ACEE_01140 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ACEE_01145 ENOG4105C6T cysteine synthase ACEE_01150 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ACEE_01155 ENOG4105CFH Aspartokinase ACEE_01165 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ACEE_01170 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ACEE_01175 ENOG4107QYX exodeoxyribonuclease v alpha ACEE_01205 ENOG4105CIN aminoacyl-histidine dipeptidase ACEE_01210 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) ACEE_01215 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ACEE_01220 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ACEE_01230 ENOG4108Z1B Cyclase dehydrase ACEE_01235 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) ACEE_01240 ENOG4105E0C molybdate abc transporter ACEE_01245 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ACEE_01250 ENOG4105E3A (ABC) transporter ACEE_01255 ENOG4105DA5 (ABC) transporter ACEE_01260 ENOG4107QMP dna polymerase iii subunits gamma and tau ACEE_01265 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ACEE_01275 ENOG4105KME endoribonuclease L-psp ACEE_01280 ENOG4105C6T cysteine synthase ACEE_01285 ENOG4108KXH Ybak prolyl-tRNA synthetase associated ACEE_01290 ENOG4105DIK (ABC) transporter ACEE_01300 ENOG4108Z0T Part of a sulfur-relay system (By similarity) ACEE_01305 ENOG4108MN8 Membrane ACEE_01310 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase ACEE_01335 ENOG4105K63 Thioredoxin ACEE_01340 ENOG4107QJR hflk protein ACEE_01345 ENOG4105EPW hflc protein ACEE_01355 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) ACEE_01360 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACEE_01375 ENOG4105E4P ATPase (AAA ACEE_01410 ENOG4108Z03 MAF-like protein ACEE_01415 ENOG4105C7N Xanthine uracil vitamin C permease ACEE_01420 ENOG41090A1 ferritin ACEE_01425 ENOG41090A1 ferritin ACEE_01430 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ACEE_01435 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ACEE_01445 ENOG4108UUE Transcriptional regulator ACEE_01455 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACEE_01465 ENOG4105C5H ABC transporter ACEE_01475 ENOG4105CUZ uba thif-type nad fad binding protein ACEE_01480 ENOG4108EKI Dehydrogenase ACEE_01485 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ACEE_01490 ENOG41076E6 Uroporphyrinogen-III Synthase ACEE_01495 ENOG4105ECF c-methyltransferase ACEE_01500 ENOG410601J HemY protein ACEE_01505 ENOG4105CKW Inner membrane protein yedI ACEE_01510 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ACEE_01515 ENOG4105EEQ Na H antiporter ACEE_01520 ENOG4105EIN peptidylprolyl cis-trans isomerase ACEE_01525 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ACEE_01530 ENOG4107TSG Extracellular solute-binding protein, family 5 ACEE_01535 ENOG4105D1F ATP-binding protein ACEE_01590 ENOG4105CNT hydrolase family 2 ACEE_01595 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ACEE_01600 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ACEE_01605 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ACEE_01615 ENOG4105DHQ Histidine kinase ACEE_01620 ENOG4105XJC Two component transcriptional regulator (Winged helix family ACEE_01630 ENOG4105WXI Bacterial OB fold (BOF) protein ACEE_01645 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ACEE_01685 ENOG4106B0W Curli production assembly transport component CsgG ACEE_01695 ENOG4107Y60 (LipO)protein ACEE_01700 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ACEE_01705 ENOG41082NX 50s ribosomal protein l35 ACEE_01710 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ACEE_01715 ENOG4108QD6 ACEE_01725 ENOG4105C37 (CBS) domain ACEE_01730 ENOG4108W1A pseudouridine synthase ACEE_01735 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ACEE_01740 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ACEE_01745 ENOG4108UJU UPF0301 protein ACEE_01750 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ACEE_01760 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACEE_01765 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACEE_01770 ENOG4107RN3 metallophosphoesterase ACEE_01775 ENOG4105CH6 catalase ACEE_01785 ENOG4105C28 cystathionine ACEE_01790 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) ACEE_01805 ENOG4105C9A Phoh family ACEE_01810 ENOG4105CV1 Transketolase (EC 2.2.1.1) ACEE_01815 ENOG4105VFB Binds the 23S rRNA (By similarity) ACEE_01825 ENOG4105EMY transcriptional regulator ACEE_01830 ENOG4105CGK Exodeoxyribonuclease III ACEE_01835 ENOG4105D3Y Na H antiporter ACEE_01845 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) ACEE_01850 ENOG4105PQ6 UPF0208 membrane protein ACEE_01865 ENOG4105NAU thioesterase Superfamily protein ACEE_01870 ENOG4105K9H YciI-like protein ACEE_01875 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ACEE_01885 ENOG4105D6U Sodium Glutamate Symporter ACEE_01900 ENOG4105XCT Protein of unknown function (DUF2489) ACEE_01905 ENOG4105D4P Coproporphyrinogen iii oxidase ACEE_01910 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ACEE_01915 ENOG4105D5K Hemolysin activator protein ACEE_01920 ENOG4105CKT filamentous hemagglutinin ACEE_01955 ENOG4105DC1 bifunctional purine biosynthesis protein purh ACEE_01965 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ACEE_01970 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ACEE_01975 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ACEE_01980 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ACEE_01985 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ACEE_01990 ENOG4105HSA Protein of unknown function (DUF452) ACEE_01995 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ACEE_02000 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ACEE_02005 ENOG4108DG9 Smr protein MutS2 ACEE_02010 ENOG4108TZV Membrane ACEE_02015 ENOG4105BZU Histidine kinase ACEE_02020 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ACEE_02025 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ACEE_02030 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ACEE_02035 ENOG4105C3J Cysteine desulfurase ACEE_02040 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ACEE_02045 ENOG4108Z4V iron-sulfur cluster assembly ACEE_02050 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) ACEE_02060 ENOG4108RF1 Protein of unknown function DUF2625 ACEE_02070 ENOG4108ZIT Ferredoxin, 2FE-2S ACEE_02075 ENOG4105WVQ Fe-S assembly protein IscX ACEE_02080 ENOG4105UGU tonB-dependent Receptor ACEE_02085 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ACEE_02090 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ACEE_02095 ENOG4105C8N cysteinyl-tRNA synthetase ACEE_02100 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ACEE_02105 ENOG4108UMI ABC transporter, permease ACEE_02110 ENOG4105D01 (LipO)protein ACEE_02115 ENOG4105D01 (LipO)protein ACEE_02120 ENOG4105D01 (LipO)protein ACEE_02125 ENOG4105EQ2 LysR family Transcriptional regulator ACEE_02130 ENOG4105ENX hydrolase ACEE_02135 ENOG4108UW5 maltose o-acetyltransferase ACEE_02145 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) ACEE_02150 ENOG4105EUJ GTP cyclohydrolase i ACEE_02160 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ACEE_02165 ENOG4105D1S lipid A biosynthesis ACEE_02170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACEE_02180 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ACEE_02195 ENOG4108WV1 Pfam:DUF477 ACEE_02205 ENOG4108V0P LemA family ACEE_02210 ENOG4105DM4 PTS System ACEE_02215 ENOG4105DE4 1-phosphofructokinase ACEE_02220 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ACEE_02230 ENOG4108ESZ Glycogen debranching enzyme ACEE_02235 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ACEE_02240 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) ACEE_02245 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ACEE_02250 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ACEE_02265 ENOG4105DNI Converts SHCHC to OSB (By similarity) ACEE_02270 ENOG4105I08 Pseudouridine synthase ACEE_02275 ENOG4105C2C drug resistance transporter, Bcr CflA ACEE_02285 ENOG4107XHZ cytoplasmic chaperone TorD family protein ACEE_02295 ENOG4107TT5 NLP P60 protein ACEE_02305 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) ACEE_02310 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ACEE_02320 ENOG4105CQ7 ATP-dependent helicase ACEE_02325 ENOG4108VMM UPF0756 membrane protein ACEE_02330 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ACEE_02335 ENOG4107RUE extracellular solute-binding protein family 1 ACEE_02340 ENOG4107QI1 Mate efflux family protein ACEE_02345 ENOG4107QKA exodeoxyribonuclease V beta ACEE_02350 ENOG4105D9N nucleoside ACEE_02355 ENOG41076CZ activating enzyme ACEE_02360 ENOG4105G0K glycine radical enzyme YjjI family ACEE_02365 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ACEE_02370 ENOG4108JU5 Magnesium and cobalt efflux protein ACEE_02375 ENOG4108Q67 UPF0319 protein ACEE_02380 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ACEE_02385 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACEE_02395 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ACEE_02400 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ACEE_02410 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ACEE_02415 ENOG4105DZP Membrane-associated zinc metalloprotease ACEE_02420 ENOG4105KNE Phosphatidate cytidylyltransferase ACEE_02425 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ACEE_02430 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ACEE_02440 ENOG4105EYK Phosphatidylglycerophosphatase B ACEE_02445 ENOG4105HBR Rna-binding protein ACEE_02450 ENOG4106WTF Glycosyl transferase, family 2 ACEE_02455 ENOG41061WM D-Alanyl-D-Alanine ACEE_02460 ENOG4105M5K heptosyltransferase ACEE_02470 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ACEE_02475 ENOG4105E96 Colicin v production protein ACEE_02480 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ACEE_02490 ENOG4105D82 Glutamate dehydrogenase ACEE_02495 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ACEE_02505 ENOG4105KME endoribonuclease L-psp ACEE_02510 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ACEE_02520 ENOG4105DFP Integrase ACEE_02600 ENOG4105E0X reductase ACEE_02605 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ACEE_02610 ENOG4105DFF Rod shape-determining protein mreb ACEE_02615 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ACEE_02625 ENOG4105D1H recombination factor protein RarA ACEE_02630 ENOG4105FAV ABC, transporter ACEE_02635 ENOG4105E7A Glutamine amidotransferase ACEE_02650 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ACEE_02655 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase ACEE_02660 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ACEE_02665 ENOG4105CMV Succinyl-CoA synthetase subunit beta ACEE_02670 ENOG4108MJ5 VirK protein ACEE_02675 ENOG4105C7S Dehydrogenase ACEE_02680 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ACEE_02685 ENOG4105FDK ABC transporter ACEE_02690 ENOG4105DR5 peptidase ACEE_02695 ENOG4105T95 Thiol disulfide interChange protein ACEE_02700 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ACEE_02710 ENOG4108K4B hydrolase ACEE_02715 ENOG4105BZU Histidine kinase ACEE_02720 ENOG4107TCE N-acetyltransferase ACEE_02725 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ACEE_02730 ENOG4105K8R UPF0145 protein ACEE_02735 ENOG4105CKU formyltetrahydrofolate synthetase ACEE_02740 ENOG4108ZZ3 UPF0260 protein ACEE_02745 ENOG4105EMU Dehydrogenase ACEE_02765 ENOG4105DVT helicase ACEE_02770 ENOG4105VAW lrga family ACEE_02775 ENOG41067MG lrgb family ACEE_02780 ENOG4105BZ1 (ABC) transporter ACEE_02790 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ACEE_02795 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ACEE_02800 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ACEE_02805 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ACEE_02810 ENOG4107QSN dihydrolipoamide acetyltransferase ACEE_02815 ENOG4107QN2 dihydrolipoyl dehydrogenase ACEE_02830 ENOG4105DFP Integrase ACEE_02860 ENOG4108UUM single-stranded DNA-binding protein ACEE_02910 ENOG4105UPP uncharacterized protein ydcA ACEE_02915 ENOG4107H6E ACEE_03010 ENOG4105EFV Major head subunit ACEE_03015 ENOG4108TVE i protein ACEE_03020 ENOG4107XYH virion morphogenesis protein ACEE_03030 ENOG4105QIB mu-like prophage Flumu protein gp29 ACEE_03105 ENOG41065S5 ACEE_03125 ENOG4105IKI host-nuclease inhibitor protein ACEE_03150 ENOG4108WTW DNA transposition protein ACEE_03160 ENOG4105R8V Transcriptional regulator ACEE_03165 ENOG4105M7P phage repressor ACEE_03175 ENOG4105ED4 portal protein ACEE_03190 ENOG4105CGH 5'-nucleotidase ACEE_03195 ENOG41080IJ Diacylglycerol kinase ACEE_03200 ENOG4108IYC Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ACEE_03205 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ACEE_03215 ENOG4105CHW UPF0052 protein ACEE_03225 ENOG4105DVA methyltransferase ACEE_03230 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system ACEE_03240 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ACEE_03245 ENOG41067MG lrgb family ACEE_03250 ENOG4105VAW lrga family ACEE_03265 ENOG4105QYK bacteriophage lambda Bor protein homolog ACEE_03270 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ACEE_03275 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) ACEE_03280 ENOG4105EV9 Alpha Beta Hydrolase ACEE_03285 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) ACEE_03290 ENOG4105CEY Amp-dependent synthetase and ligase ACEE_03295 ENOG4105EGS Mechanosensitive ion channel ACEE_03300 ENOG4105EGS Mechanosensitive ion channel ACEE_03310 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) ACEE_03315 ENOG4105G6Z alkaline phosphatase ACEE_03320 ENOG4108IYH Dna topoisomerase ACEE_03340 ENOG4105C0H protease ACEE_03345 ENOG4105CAT Cytidine monophosphate kinase ACEE_03350 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ACEE_03355 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ACEE_03360 ENOG4105Q4A inner membrane protein yciS ACEE_03365 ENOG4105CFV Tetratricopeptide repeat protein ACEE_03370 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) ACEE_03375 ENOG4108ZJT translation initiation factor, Sui1 ACEE_03380 ENOG4108ZPB UPF0306 protein ACEE_03385 ENOG4108UQV Membrane ACEE_03390 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ACEE_03400 ENOG4105N42 UPF0307 protein ACEE_03405 ENOG4105CMS peptidase U62, modulator of DNA gyrase ACEE_03410 ENOG4108ZP8 Acetolactate synthase small subunit ACEE_03415 ENOG4105C7K acetolactate synthase ACEE_03420 ENOG41077A9 carbonic anhydrase ACEE_03425 ENOG4105VEQ Cold shock protein ACEE_03430 ENOG4105F3T (LipO)protein ACEE_03440 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ACEE_03445 ENOG4105NSG hemerythrin hhe cation binding domain protein ACEE_03455 ENOG4105CJ3 phosphate transporter ACEE_03460 ENOG4107IX6 phosphate transport regulator ACEE_03465 ENOG4108IPW abc transporter atp-binding protein ACEE_03470 ENOG4105CM4 permease protein ACEE_03475 ENOG4105DHS permease protein ACEE_03485 ENOG4105CDU Replicative dna helicase ACEE_03490 ENOG4105VNG YcgL domain-containing protein ACEE_03495 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ACEE_03500 ENOG4105CFH Aspartokinase ACEE_03510 ENOG4105C9X ppx gppa phosphatase ACEE_03515 ENOG4108R66 Conserved Protein ACEE_03520 ENOG4105QEK Transcriptional regulator ACEE_03525 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ACEE_03535 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ACEE_03540 ENOG4108EKC n-acetylglutamate synthase ACEE_03545 ENOG4105CC0 LysR family Transcriptional regulator ACEE_03550 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ACEE_03555 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) ACEE_03560 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ACEE_03565 ENOG4108ZAF Molybdopterin ACEE_03570 ENOG4105M00 molybdopterin converting factor, subunit 1 ACEE_03575 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ACEE_03585 ENOG4105CUW cytochrome C-TYPE protein ACEE_03590 ENOG4107QY8 reductase ACEE_03595 ENOG4105M08 Membrane ACEE_03610 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ACEE_03615 ENOG4105C28 cystathionine ACEE_03625 ENOG4108UGV hypoxanthine phosphoribosyltransferase ACEE_03630 ENOG4107SC1 transglycosylase ACEE_03650 ENOG4105CX6 glutaminyL-tRNA synthetase ACEE_03655 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ACEE_03665 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ACEE_03670 ENOG4105C5S asparaginyl-tRNA synthetase ACEE_03675 ENOG4105CJB Exodeoxyribonuclease I ACEE_03685 ENOG4105DB7 PHP domain protein ACEE_03695 ENOG4105DBE peroxidase ACEE_03705 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ACEE_03715 ENOG4107RAQ aminopeptidase ACEE_03720 ENOG4105CGF Aromatic amino acid aminotransferase ACEE_03725 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ACEE_03730 ENOG4105HDK L-asparaginase ACEE_03735 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ACEE_03740 ENOG4107MKT Stringent starvation protein a ACEE_03745 ENOG4105KB2 stringent starvation protein b ACEE_03750 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ACEE_03765 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ACEE_03770 ENOG4108J3C UTP-glucose-1-phosphate uridylyltransferase ACEE_03915 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ACEE_03925 ENOG4108DNC Involved in acetate metabolism (By similarity) ACEE_03930 ENOG4107EPN Domain of unknown function (DUF1508) ACEE_03935 ENOG4105CXG d-lactate dehydrogenase ACEE_03940 ENOG4105CVE Lytic murein transglycosylase ACEE_03945 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ACEE_03950 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ACEE_03955 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ACEE_03960 ENOG4105CHV Transcription elongation factor NusA ACEE_03965 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ACEE_03975 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ACEE_03990 ENOG4105DXN mazG family ACEE_03995 ENOG4105E3W Two component transcriptional regulator (Winged helix family ACEE_04000 ENOG4105E0F Histidine kinase ACEE_04005 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACEE_04010 ENOG4107QNR UPF0135 protein ACEE_04015 ENOG4105CBT Fructose-1,6-bisphosphatase ACEE_04025 ENOG4107104 thymidine kinase ACEE_04030 ENOG41072GX Peptidase M22 Glycoprotease ACEE_04035 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ACEE_04040 ENOG4105CGZ zinc metallopeptidase ACEE_04045 ENOG4105CNU cell division protein FtsK ACEE_04050 ENOG4105EW9 transcriptional regulator AsnC family ACEE_04055 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ACEE_04060 ENOG4105E2R ROK family ACEE_04065 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ACEE_04070 ENOG4108QBX (LipO)protein ACEE_04075 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ACEE_04080 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ACEE_04085 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ACEE_04090 ENOG4108RCM Nitroreductase ACEE_04095 ENOG4107R6U sodium dicarboxylate symporter ACEE_04100 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein ACEE_04105 ENOG41076HS cation diffusion facilitator family transporter ACEE_04130 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ACEE_04135 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III ACEE_04140 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ACEE_04145 ENOG4105E0U tyrosine-specific transport protein ACEE_04150 ENOG4105E0U tyrosine-specific transport protein ACEE_04155 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACEE_04160 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ACEE_04165 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ACEE_04180 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ACEE_04185 ENOG4105TWJ Domain of unknown function (DUF1919) ACEE_04200 ENOG4105BZS acriflavin resistance protein ACEE_04205 ENOG410624X efflux transporter, rnd family, mfp subunit ACEE_04210 ENOG4105Y7M Transcriptional regulator, TetR family ACEE_04220 ENOG4105E68 Sulfatase ACEE_04225 ENOG4105C7F AcnD-accessory protein PrpF ACEE_04230 ENOG4107QPK )-transporter ACEE_04235 ENOG4105FDP GntR family transcriptional regulator ACEE_04240 ENOG4107QIJ Aconitate hydratase 2 ACEE_04245 ENOG4105F27 Major Facilitator ACEE_04255 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) ACEE_04265 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACEE_04270 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ACEE_04275 ENOG4105RT1 May be involved in cell division (By similarity) ACEE_04280 ENOG4105C1J atp-dependent rna helicase ACEE_04285 ENOG4108Z6B deaminase ACEE_04295 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) ACEE_04300 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACEE_04305 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ACEE_04310 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ACEE_04315 ENOG4108I6E Sulfatase ACEE_04320 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ACEE_04335 ENOG4105CQ0 ABC transporter ACEE_04345 ENOG4107RCV ABC transporter, permease ACEE_04350 ENOG4105C4Y ABC transporter ACEE_04355 ENOG4105D7A ATP-binding protein ACEE_04365 ENOG4105C1J atp-dependent rna helicase ACEE_04445 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ACEE_04450 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ACEE_04455 ENOG4105C3F Signal peptidase i ACEE_04460 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ACEE_04470 ENOG4105DWF phosphomethylpyrimidine kinase ACEE_04475 ENOG4107Z6I Thiamine biosynthesis protein ACEE_04480 ENOG4105ETU transcriptional activator (TenA ACEE_04485 ENOG4105D41 biosynthesis protein thiH ACEE_04490 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ACEE_04500 ENOG4105D06 uba thif-type nad fad binding protein ACEE_04505 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component ACEE_04510 ENOG4108YI8 ABC transporter ACEE_04520 ENOG4105BZG amino acid carrier protein ACEE_04525 ENOG4105D7X high-affinity nickel-transporter ACEE_04530 ENOG41065CD Exported protein ACEE_04535 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ACEE_04540 ENOG4105C6K Malic enzyme ACEE_04545 ENOG4107QPK )-transporter ACEE_04550 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ACEE_04555 ENOG4105CHY citrate lyase, alpha ACEE_04560 ENOG4105CI0 Citrate lyase ACEE_04565 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) ACEE_04570 ENOG4105SYT Methylenetetrahydrofolate reductase ACEE_04575 ENOG41080C8 DUF218 domain ACEE_04590 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase ACEE_04595 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) ACEE_04600 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) ACEE_04605 ENOG4105C2M dna polymerase I ACEE_04615 ENOG4105X5T ACEE_04620 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ACEE_04625 ENOG4108UUM single-stranded DNA-binding protein ACEE_04645 ENOG4105E0M Sulfatase ACEE_04650 ENOG4105QVC MOSC domain-containing protein ACEE_04660 ENOG4105CTB Polyprenyl synthetase ACEE_04670 ENOG4105CRK lysyL-tRNA synthetase ACEE_04675 ENOG4105C03 ribonuclease ACEE_04680 ENOG4105DDY UPF0142 protein ycaO ACEE_04685 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) ACEE_04695 ENOG4105CA3 membrane-bound lytic murein transglycosylase ACEE_04720 ENOG4105CDU Replicative dna helicase ACEE_04755 ENOG4108UUM single-stranded DNA-binding protein ACEE_04770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ACEE_04955 ENOG4108C33 Resolvase ACEE_04985 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein ACEE_04990 ENOG4108EU3 peptide transport system, permease ACEE_05000 ENOG4108EVY peptide transport periplasmic protein ACEE_05005 ENOG4108JU8 Transcriptional regulator ACEE_05010 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ACEE_05015 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator ACEE_05020 ENOG4107S6Z Na H antiporter ACEE_05025 ENOG4108SAU DNA-binding protein H-ns ACEE_05030 ENOG4105DAA L-lactate ACEE_05035 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ACEE_05040 ENOG4107QR9 Iron-sulfur cluster binding protein ACEE_05045 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) ACEE_05050 ENOG4107GZ4 SanA protein ACEE_05055 ENOG4105DWV Homoserine O-trans-acetylase ACEE_05070 ENOG4108VD1 dedA family ACEE_05075 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACEE_05080 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) ACEE_05085 ENOG4105E98 transcriptional regulator DeoR family ACEE_05090 ENOG4107QTF adenylosuccinate lyase ACEE_05095 ENOG41075W9 High frequency lysogenization protein HflD homolog ACEE_05105 ENOG4108JJ8 (ABC) transporter ACEE_05110 ENOG4108JJ9 ABC, transporter ACEE_05115 ENOG4105MA0 exported protein ACEE_05120 ENOG4105CFU surface antigen ACEE_05125 ENOG4105PXI polysaccharide deacetylase ACEE_05130 ENOG41063SB peptidase ACEE_05135 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ACEE_05140 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ACEE_05145 ENOG4105DBI uridine monophosphokinase ACEE_05150 ENOG4105DHP deoxycytidine triphosphate deaminase ACEE_05155 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ACEE_05160 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ACEE_05165 ENOG4105CVS RNA methyltransferase TrmH family, group 1 ACEE_05175 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ACEE_05180 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ACEE_05185 ENOG4105CSA Coproporphyrinogen iii oxidase ACEE_05190 ENOG4107QSI ABC, transporter ACEE_05205 ENOG4108JQ7 (ABC) transporter ACEE_05220 ENOG4105DEF Extracellular solute-binding protein, family 5 ACEE_05225 ENOG4105C44 Serine transporter ACEE_05230 ENOG4105EJQ L-serine dehydratase ACEE_05245 ENOG4105DK0 Indole-3-glycerol phosphate synthase ACEE_05250 ENOG4105WP7 tRNA pseudouridine synthase C ACEE_05255 ENOG4105DR9 pseudouridine synthase ACEE_05270 ENOG4105I7R Adenylate cyclase ACEE_05275 ENOG4105CM6 amino acid regulated cytosolic protein ACEE_05280 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ACEE_05295 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) ACEE_05305 ENOG4105C8T Leucyl-tRNA synthetase ACEE_05315 ENOG4105DJF DNA polymerase III, delta' subunit ACEE_05320 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) ACEE_05325 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ACEE_05335 ENOG4105D7Q type ii secretion system ACEE_05340 ENOG4107QHF type ii secretion system protein e ACEE_05350 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ACEE_05360 ENOG4105C2X Arabinose 5-phosphate isomerase ACEE_05365 ENOG4108RRZ Transcription elongation factor GreB ACEE_05380 ENOG4108R6K riboflavin synthase, subunit alpha ACEE_05385 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ACEE_05395 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ACEE_05400 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B ACEE_05405 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ACEE_05410 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ACEE_05415 ENOG4105CXY transporter ACEE_05425 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ACEE_05435 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACEE_05445 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ACEE_05450 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) ACEE_05455 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) ACEE_05460 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ACEE_05465 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ACEE_05470 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ACEE_05475 ENOG4105CEY Amp-dependent synthetase and ligase ACEE_05485 ENOG41069PW sigma-e factor negative regulatory protein ACEE_05490 ENOG4105EMN RNA polymerase sigma factor ACEE_05500 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ACEE_05505 ENOG4105DQF Hydrolase ACEE_05515 ENOG4105C09 Bile acid ACEE_05520 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family ACEE_05530 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) ACEE_05535 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ACEE_05540 ENOG4105EJ9 Membrane ACEE_05545 ENOG4105CSM endonuclease III ACEE_05570 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ACEE_05575 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACEE_05580 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACEE_05585 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ACEE_05590 ENOG4108MG3 formate dehydrogenase ACEE_05595 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) ACEE_05600 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ACEE_05605 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) ACEE_05610 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ACEE_05615 ENOG4108IUZ ABC transporter ACEE_05620 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ACEE_05625 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ACEE_05630 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ACEE_05650 ENOG4105D0A hydroxylase ACEE_05660 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) ACEE_05665 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ACEE_05680 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ACEE_05685 ENOG4105D6S protein involved in catabolism of external DNA ACEE_05690 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ACEE_05695 ENOG4105D3G Pseudouridine synthase ACEE_05710 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ACEE_05715 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ACEE_05725 ENOG4105D06 uba thif-type nad fad binding protein ACEE_05730 ENOG4105CVM Molybdenum cofactor synthesis domain protein ACEE_05735 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ACEE_05740 ENOG4105C5H ABC transporter ACEE_05745 ENOG4106K28 UPF0283 membrane protein ACEE_05750 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ACEE_05760 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) ACEE_05765 ENOG4105KCK Peptidoglycan-associated lipoprotein ACEE_05770 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ACEE_05785 ENOG4105E02 MotA TolQ exbB proton channel ACEE_05790 ENOG4107YD3 Thioesterase ACEE_05805 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ACEE_05810 ENOG4105C4M (Ubiquinol oxidase) subunit I ACEE_05830 ENOG4105M6F mutator MutT protein ACEE_05870 ENOG4105M85 Bola protein ACEE_05880 ENOG4106NDP Transcriptional regulator ACEE_05895 ENOG4108JQ5 ABC transporter ACEE_05900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACEE_05905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACEE_05920 ENOG4105D38 putrescine abc transporter ACEE_05925 ENOG4105F38 ABC transporter, permease ACEE_05930 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACEE_05935 ENOG4105C4R Atp-dependent dna helicase ACEE_05940 ENOG4108RE7 deoxyribonuclease ACEE_05955 ENOG4105D5Q Arginine ornithine antiporter ACEE_05960 ENOG4105D5Q Arginine ornithine antiporter ACEE_05970 ENOG4105CWC Acetylornithine deacetylase ACEE_05975 ENOG4105EIF outer membrane protein W ACEE_05980 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACEE_05985 ENOG4108IJ0 Aspartate ammonia-lyase ACEE_05995 ENOG4105CXB phosphoribosylaminoimidazole synthetase ACEE_06000 ENOG41069UX Beta-N-acetyl-hexosaminidase ACEE_06010 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ACEE_06015 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ACEE_06020 ENOG4105CXY transporter ACEE_06025 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ACEE_06035 ENOG4108M8S permease YjgP YjgQ family protein ACEE_06040 ENOG4108K5H permease YjgP YjgQ family protein ACEE_06045 ENOG4105C0B DNA polymerase III (alpha subunit) ACEE_06050 ENOG4108JJA ABC, transporter ACEE_06055 ENOG4108MBX Secretion Protein ACEE_06065 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ACEE_06075 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACEE_06085 ENOG4105EE5 Membrane protein terC ACEE_06095 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) ACEE_06100 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ACEE_06105 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) ACEE_06115 ENOG4105C9U ATP-dependent DNA helicase RecQ ACEE_06120 ENOG4105XQ6 frataxin-like protein ACEE_06130 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ACEE_06135 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ACEE_06140 ENOG4105C34 Pseudouridine synthase ACEE_06145 ENOG4108VTV Inherit from NOG: Membrane ACEE_06150 ENOG4105CTQ phosphohexokinase ACEE_06155 ENOG4105C9B Cysteine desulfurase ACEE_06165 ENOG4105BZG amino acid carrier protein ACEE_06170 ENOG4105DSF transport protein ACEE_06180 ENOG4105CFP Peptidase U32 ACEE_06185 ENOG4105PF3 O-Antigen polymerase ACEE_06190 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ACEE_06200 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ACEE_06210 ENOG4105K8N protein family UPF0079, ATPase ACEE_06215 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ACEE_06220 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ACEE_06225 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ACEE_06230 ENOG4108BY2 phosphohistidine phosphatase ACEE_06235 ENOG4105CA9 Pyruvate kinase ACEE_06240 ENOG4105DKP glycosyl transferase, family 9 ACEE_06245 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ACEE_06250 ENOG4105EHE chorismate mutase- prephenate dehydrogenase ACEE_06255 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ACEE_06260 ENOG4105ECY inositol monophosphatase ACEE_06265 ENOG4105EIB trna rrna methyltransferase ACEE_06270 ENOG4105CCF Lysine exporter protein (Lyse ygga) ACEE_06275 ENOG4108ZAI phosphatidylglycerophosphatase a ACEE_06280 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ACEE_06285 ENOG4107YIM Involved in the transcription termination process (By similarity) ACEE_06290 ENOG4105E4G Type IV pilus ACEE_06315 ENOG4108JQC penicillin-binding protein 1A ACEE_06320 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ACEE_06325 ENOG4105D49 3-dehydroquinate synthase ACEE_06330 ENOG4105DFE Dna adenine methylase ACEE_06335 ENOG4105C8J )-transporter ACEE_06340 ENOG4107QP8 phosphohexose isomerase ACEE_06345 ENOG4105W0Z cytoplasmic protein ACEE_06370 ENOG4105E2X shikimate dehydrogenase ACEE_06380 ENOG4108WI1 Dna topoisomerase ACEE_06385 ENOG41060QA UPF0267 protein ACEE_06390 ENOG4105Y3E Modulates RecA activity (By similarity) ACEE_06395 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ACEE_06405 ENOG4105CRQ synthase (Component I) ACEE_06410 ENOG4105CGY Dna recombination protein ACEE_06415 ENOG4105DDQ anthranilate synthase ACEE_06425 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ACEE_06440 ENOG4105D6A Electron transport complex ACEE_06445 ENOG4105EN6 Membrane ACEE_06450 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) ACEE_06455 ENOG4108R3D Electron transport complex ACEE_06460 ENOG4105DGN Electron transport complex ACEE_06470 ENOG4108JJA ABC, transporter ACEE_06490 ENOG4105HEI LysR family (Transcriptional regulator ACEE_06500 ENOG4108RYK Nad-dependent epimerase dehydratase ACEE_06505 ENOG4107VXZ Hydrolase ACEE_06515 ENOG4105II7 pyrroline-5-carboxylate reductase ACEE_06520 ENOG4105D8G Major Facilitator superfamily ACEE_06525 ENOG4105DUA (citrate (pro-3S)-lyase ligase ACEE_06540 ENOG4105CJ2 (LipO)protein ACEE_06545 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) ACEE_06550 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACEE_06555 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACEE_06560 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACEE_06565 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACEE_06570 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACEE_06575 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) ACEE_06580 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ACEE_06585 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACEE_06600 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ACEE_06605 ENOG4105EWT decarboxylase family ACEE_06610 ENOG4105CPB ATP-dependent endonuclease of the OLD family ACEE_06615 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ACEE_06620 ENOG4105BZW Glycerate kinase ACEE_06625 ENOG4107QQ0 gntp family ACEE_06630 ENOG4107VHA regulatoR ACEE_06635 ENOG4108J59 Extracellular solute-binding protein, family 5 ACEE_06665 ENOG4105HDK L-asparaginase ACEE_06675 ENOG4107R11 Transcriptional regulator ACEE_06680 ENOG4105PAD Hydrolase ACEE_06685 ENOG4105ETT transcriptional Regulator, LysR family ACEE_06690 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ACEE_06700 ENOG4105CC5 ABC transporter ACEE_06705 ENOG4105CC5 ABC transporter ACEE_06710 ENOG4105K59 histidine triad (HIT) protein ACEE_06725 ENOG4105C5X domain protein ACEE_06730 ENOG4105EAQ (twin-arginine translocation) pathway signal ACEE_06735 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ACEE_06740 ENOG4105CN1 protease ACEE_06745 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) ACEE_06750 ENOG4105VEQ Cold shock protein ACEE_06755 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ACEE_06765 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ACEE_06770 ENOG4105K70 DNA-binding protein ACEE_06775 ENOG4105R2J Conserved Protein ACEE_06785 ENOG4105E07 UPF0149 protein ACEE_06795 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ACEE_06800 ENOG41069M3 Transcriptional regulator ACEE_06805 ENOG4105CK7 Sodium proline symporter ACEE_06810 ENOG4105C26 Dehydrogenase ACEE_06815 ENOG4105C2W permease ACEE_06905 ENOG4105CKT filamentous hemagglutinin ACEE_06910 ENOG4105D5K Hemolysin activator protein ACEE_06920 ENOG4105DVI reductase, NrfD ACEE_06925 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ACEE_06930 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit ACEE_06935 ENOG4105EAU Plays a role in nitrite reduction (By similarity) ACEE_06940 ENOG4105C5I Dehydrogenase ACEE_06950 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit ACEE_06955 ENOG4105F0N pyrophosphate phospho-hydrolase ACEE_06960 ENOG4105C01 Dihydroxy-acid dehydratase ACEE_06975 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ACEE_06980 ENOG41068D6 Glycosyltransferase ACEE_06995 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) ACEE_07000 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 ACEE_07010 ENOG4108R99 pseudouridine synthase ACEE_07020 ENOG4105VP5 Bacterial protein of unknown function (DUF937) ACEE_07025 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) ACEE_07030 ENOG4105C3M thioredoxin reductase ACEE_07035 ENOG4105CMT Dihydroxyacetone kinase ACEE_07040 ENOG4108UTZ Dihydroxyacetone kinase ACEE_07045 ENOG4105VDH Dihydroxyacetone kinase ACEE_07050 ENOG4107QR8 Thioredoxin ACEE_07060 ENOG4105M8K biopolymer transport protein ACEE_07065 ENOG4105M15 transport protein ExbD ACEE_07075 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) ACEE_07080 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ACEE_07085 ENOG4105M2J Glutaredoxin ACEE_07090 ENOG4105CM2 brancheD-chain amino acid aminotransferase ACEE_07095 ENOG4105M4H endoribonuclease L-psp ACEE_07105 ENOG4108JQ7 (ABC) transporter ACEE_07110 ENOG4105C3U ABC transporter ACEE_07115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACEE_07120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACEE_07125 ENOG4105DEF Extracellular solute-binding protein, family 5 ACEE_07130 ENOG4105DEF Extracellular solute-binding protein, family 5 ACEE_07160 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ACEE_07170 ENOG4105WH1 Two component transcriptional regulator luxr family ACEE_07175 ENOG4105CG3 alpha amylase, catalytic region ACEE_07180 ENOG4105C5Y PTS System ACEE_07185 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ACEE_07190 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ACEE_07195 ENOG4105DSJ YicC domain protein ACEE_07205 ENOG41090BQ Glutaredoxin ACEE_07215 ENOG4105CI3 gtp-binding protein typa ACEE_07220 ENOG4105DFA alanine racemase domain protein ACEE_07225 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ACEE_07235 ENOG41065U4 response regulator ACEE_07240 ENOG4108VVQ metallophosphoesterase ACEE_07245 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase ACEE_07250 ENOG4105DTN riboflavin biosynthesis protein ribF ACEE_07255 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ACEE_07260 ENOG4105JIM Phosphatidylserine synthase ACEE_07265 ENOG4105C2N RNA methyltransferase TrmH family group 3 ACEE_07270 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) ACEE_07280 ENOG4105C75 arginyL-tRNA synthetase ACEE_07285 ENOG4105NBI YecM protein ACEE_07290 ENOG4108XTF Outer Membrane Lipoprotein ACEE_07305 ENOG4105C3G gtp-binding protein ACEE_07310 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ACEE_07335 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein ACEE_07340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACEE_07345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACEE_07350 ENOG4108JQ5 ABC transporter ACEE_07355 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ACEE_07360 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ACEE_07365 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ACEE_07370 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ACEE_07380 ENOG4105CPF Cell wall formation (By similarity) ACEE_07390 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ACEE_07395 ENOG4105CNI cell division protein FtsW ACEE_07400 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ACEE_07410 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ACEE_07415 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ACEE_07420 ENOG4105CJN penicillin-binding protein ACEE_07430 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ACEE_07440 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ACEE_07445 ENOG4105F0S class B acid phosphatase ACEE_07455 ENOG4105DBV ornithine carbamoyltransferase ACEE_07460 ENOG4105C5B carbamate kinase ACEE_07465 ENOG4105C5Y PTS System ACEE_07470 ENOG4107T0D ABC, transporter ACEE_07475 ENOG4106SMU thiamine transporter membrane protein ACEE_07480 ENOG4105KZ7 phosphocarrier protein hpr ACEE_07485 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ACEE_07490 ENOG4105C5Y PTS System ACEE_07495 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ACEE_07500 ENOG4108KBJ Inner membrane protein YkgB ACEE_07505 ENOG4105CEI nitrite reductase ACEE_07510 ENOG4105D7K pfkb domain protein ACEE_07520 ENOG4105WBN Transcriptional regulator (LacI family ACEE_07560 ENOG4108JA2 transcriptioN-repair coupling factor ACEE_07570 ENOG4105CD8 aminopeptidase N ACEE_07575 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ACEE_07580 ENOG4107ZVW dihydroneopterin aldolase ACEE_07585 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) ACEE_07590 ENOG4105QYV Membrane ACEE_07595 ENOG4105K46 50S ribosomal protein l27 ACEE_07600 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ACEE_07605 ENOG4105MGM doxx family ACEE_07610 ENOG4108YYH Nadph-dependent fmn reductase ACEE_07615 ENOG4105EAH synthase ACEE_07620 ENOG4105WPN DNA integration recombination invertion protein ACEE_07625 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ACEE_07630 ENOG4105CHR reductase ACEE_07635 ENOG4105CWM branched-chain amino acid transport system II carrier protein ACEE_07650 ENOG4105D52 delta-aminolevulinic acid dehydratase ACEE_07655 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ACEE_07660 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ACEE_07665 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ACEE_07670 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ACEE_07680 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACEE_07685 ENOG4107QUT magnesium and cobalt transport protein CorA ACEE_07705 ENOG4108WFC UPF0438 protein yifE ACEE_07710 ENOG4105DY8 decarboxylase ACEE_07715 ENOG4108JPW Aminotransferase ACEE_07720 ENOG4105W0E 50S ribosomal protein L33 ACEE_07725 ENOG4105KDC 50s ribosomal protein l28 ACEE_07730 ENOG4105W5Q DNA repair protein (RadC ACEE_07735 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ACEE_07745 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) ACEE_07750 ENOG4105YP7 UPF0270 protein ACEE_07755 ENOG4107RYR Transcriptional regulator, Crp Fnr family ACEE_07760 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain ACEE_07765 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ACEE_07770 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ACEE_07805 ENOG4107S2Z UPF0761 membrane protein ACEE_07810 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ACEE_07820 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ACEE_07830 ENOG4105W8Z 4'-phosphopantetheinyl transferase ACEE_07840 ENOG41087AY ADP-Ribose pyrophosphatase ACEE_07845 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ACEE_07850 ENOG4105C5F glutamine synthetase ACEE_07855 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ACEE_07860 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ACEE_07865 ENOG4105VG0 50S ribosomal protein l34 ACEE_07875 ENOG41074DU domain protein ACEE_07880 ENOG4108P2H Inner membrane protein YjiG ACEE_07890 ENOG4108R3E Dna-3-methyladenine glycosylase i ACEE_07900 ENOG4108K5P (LipO)protein ACEE_07915 ENOG4108UM1 dedA family ACEE_07920 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ACEE_07925 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) ACEE_07930 ENOG4105CP7 Triose-phosphate isomerase ACEE_07945 ENOG4105CND Glycosyl transferase, family 2 ACEE_07950 ENOG4107BJW polysaccharide deacetylase ACEE_07960 ENOG4108IQE Amp-dependent synthetase and ligase ACEE_07970 ENOG4105DSB aldose 1-epimerase ACEE_07975 ENOG410903C (LipO)protein ACEE_07980 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) ACEE_07985 ENOG4105RG0 Membrane ACEE_07990 ENOG4108IA2 Sodium pantothenate symporter ACEE_08015 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ACEE_08020 ENOG4108I5D sulfate abc transporter ACEE_08025 ENOG4105ECW sulfate abc transporter ACEE_08030 ENOG4108IJ6 ABC transporter ACEE_08045 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ACEE_08050 ENOG4105H2K paraquat-inducible protein a ACEE_08055 ENOG4108KS2 transglutaminase domain protein ACEE_08065 ENOG410681U heavy metal transport detoxification protein ACEE_08070 ENOG4105C26 Dehydrogenase ACEE_08075 ENOG4108W3Q Transcriptional regulator ACEE_08085 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein ACEE_08090 ENOG4105E4P ATPase (AAA ACEE_08110 ENOG4105EXG Transcriptional regulator ACEE_08145 ENOG4105ECQ AraC Family Transcriptional Regulator ACEE_08160 ENOG4107ZXU DSBA oxidoreductase ACEE_08175 ENOG4105CBP Major Facilitator ACEE_08195 ENOG4108ZHJ Organic hydroperoxide resistance protein ACEE_08200 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACEE_08215 ENOG4108ZHJ Organic hydroperoxide resistance protein ACEE_08240 ENOG4105CF7 AraC family transcriptional regulator ACEE_08245 ENOG4108RCM Nitroreductase ACEE_08260 ENOG4105CY2 Citrate transporter ACEE_08270 ENOG4105CHU acetyl-coa acetyltransferase ACEE_08275 ENOG4105CRW Short chain fatty acid transporter ACEE_08280 ENOG4107QNJ CoA-transferase subunit B ACEE_08285 ENOG4107QP7 CoA-transferase subunit A ACEE_08290 ENOG4105CMU LysR family (Transcriptional regulator ACEE_08295 ENOG4108PTX LysR family Transcriptional regulator ACEE_08300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACEE_08305 ENOG4105DEN Luciferase family ACEE_08310 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ACEE_08315 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ACEE_08320 ENOG4107T7U Sulfatase ACEE_08325 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ACEE_08330 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ACEE_08335 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b ACEE_08345 ENOG4108Z33 Thiol disulfide Interchange Protein ACEE_08355 ENOG41063M6 Cell Division Protein ACEE_08355 ENOG41063M6 Cell Division Protein ACEE_08360 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) ACEE_08375 ENOG4105KUZ arsenate reductase ACEE_08385 ENOG4105EEI dihydropteroate synthase ACEE_08400 ENOG4105EI2 Pseudouridine synthase ACEE_08410 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ACEE_08425 ENOG4105TMB Formate nitrite transporter ACEE_08430 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ACEE_08450 ENOG4105HF0 Membrane ACEE_08475 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ACEE_08480 ENOG4105C31 Tryptophanyl-tRNA synthetase ACEE_08490 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) ACEE_08495 ENOG4105DAN ATP-dependent protease ACEE_08500 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) ACEE_08525 ENOG4105DSY exodeoxyribonuclease V, gamma ACEE_08530 ENOG4107QXK peptidase ACEE_08540 ENOG4105CFG Acts as a chaperone (By similarity) ACEE_08545 ENOG4105CMG Carbohydrate kinase ACEE_08550 ENOG4105C93 Xylose Isomerase ACEE_08555 ENOG4105DFW ABC transporter ACEE_08560 ENOG4105C2J ABC transporter ACEE_08565 ENOG4108HWW ABC transporter ACEE_08570 ENOG4105CT4 transporter ACEE_08575 ENOG4105DSG hydrolase family 43 ACEE_08580 ENOG4105T16 Transcriptional regulator (AraC family) ACEE_08585 ENOG4105C9K Endothelin-converting enzyme 1 ACEE_08595 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ACEE_08635 ENOG4108UHE carbonic anhydrase ACEE_08640 ENOG410807V Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) ACEE_08645 ENOG4108I5U Uridine phosphorylase ACEE_08650 ENOG4108VVK transcriptional Regulator, AsnC ACEE_08655 ENOG4105CU9 asparagine synthetase A ACEE_08660 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) ACEE_08665 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) ACEE_08670 ENOG4108WQI RNA Polymerase ACEE_08680 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ACEE_08685 ENOG4105CB5 ATP-dependent DNA helicase recG ACEE_08690 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ACEE_08715 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACEE_08720 ENOG4108IPT Naphthoate synthase ACEE_08725 ENOG4105BZ4 penicillin-binding protein ACEE_08730 ENOG4105YK5 50S ribosomal protein L36 ACEE_08735 ENOG4105NRA 50s ribosomal protein l31 type b ACEE_08740 ENOG4105DJV ribulose-phosphate 3-epimerase ACEE_08745 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ACEE_08765 ENOG4105HHA aminodeoxychorismate lyase ACEE_08770 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ACEE_08775 ENOG4107QRG dna polymerase iii ACEE_08780 ENOG4105F8V Hydrolase, tatD family ACEE_08785 ENOG4105RX8 Protein of unknown function (DUF1523) ACEE_08790 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) ACEE_08795 ENOG4105K64 Glycosyl transferase, family 2 ACEE_08800 ENOG4105WD1 Membrane ACEE_08845 ENOG4108J2R molybdopterin oxidoreductase ACEE_08875 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) ACEE_08880 ENOG4105S10 periplasmic binding protein ACEE_08885 ENOG4105EZE Cupin 4 family protein ACEE_08890 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ACEE_08895 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ACEE_08900 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ACEE_08905 ENOG4105K5M 30s ribosomal protein S16 ACEE_08915 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ACEE_08920 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ACEE_08925 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ACEE_08930 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ACEE_08940 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ACEE_08945 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ACEE_08950 ENOG4105VPB 50S ribosomal protein L30 ACEE_08955 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ACEE_08960 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ACEE_08965 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ACEE_08970 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ACEE_08975 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ACEE_08980 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ACEE_08985 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ACEE_08995 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ACEE_09000 ENOG41083MP 50s ribosomal protein l29 ACEE_09005 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ACEE_09010 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ACEE_09015 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ACEE_09020 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ACEE_09025 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ACEE_09030 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ACEE_09035 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ACEE_09040 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ACEE_09055 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ACEE_09060 ENOG4105CJR Integral membrane protein (MviN ACEE_09080 ENOG4105EM7 Selenocysteine-specific translation elongation factor ACEE_09085 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ACEE_09090 ENOG4105C1A potassium transporter peripheral membrane ACEE_09095 ENOG4105C9Q fumarate hydratase class II ACEE_09100 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ACEE_09105 ENOG4105D1U peptidase U62 modulator of DNA gyrase ACEE_09110 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ACEE_09120 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACEE_09180 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family ACEE_09185 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) ACEE_09195 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) ACEE_09200 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ACEE_09205 ENOG4105EGZ biosynthesis protein ACEE_09210 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACEE_09220 ENOG4108IJ1 Dehydrogenase ACEE_09225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ACEE_09235 ENOG4105ESV Glycosyl transferase, family 4 ACEE_09255 ENOG4105C42 Type I secretion membrane fusion protein (HlyD ACEE_09265 ENOG4105CE4 GlcNAc 6-P deacetylase ACEE_09270 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ACEE_09275 ENOG4108MB0 N-acetylneuraminate lyase ACEE_09280 ENOG4105EVU fructokinase ACEE_09285 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) ACEE_09295 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ACEE_09300 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ACEE_09305 ENOG4106IIQ Outer membrane lipoprotein ACEE_09310 ENOG4105C0P Mg chelatase subunit ChlI ACEE_09315 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ACEE_09320 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ACEE_09340 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ACEE_09345 ENOG4108VZM 50s ribosomal protein L10 ACEE_09350 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ACEE_09355 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ACEE_09360 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ACEE_09365 ENOG4105PM1 preprotein translocase subunit SecE ACEE_09380 ENOG4105EPD Oligopeptide transporter, Opt family ACEE_09385 ENOG4105C79 DNA protecting protein DprA ACEE_09395 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ACEE_09400 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) ACEE_09405 ENOG410814C multidrug resistance protein ACEE_09410 ENOG4105KZW UPF0381 protein ACEE_09425 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) ACEE_09430 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) ACEE_09435 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) ACEE_09440 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) ACEE_09460 ENOG4108YZ9 Urea amidohydrolase subunit gamma ACEE_09470 ENOG4108JJB ABC transporter ACEE_09480 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein ACEE_09485 ENOG4108A51 ACEE_09490 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component ACEE_09495 ENOG4108M0I Transcriptional regulator ACEE_09505 ENOG4107QWE )-transporter ACEE_09510 ENOG4107QWE )-transporter ACEE_09525 ENOG4105CTS PTS system mannitol-specific ACEE_09530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ACEE_09535 ENOG410804X Transcriptional regulator ACEE_09545 ENOG4106YJS accessory processing protein ACEE_09550 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) ACEE_09555 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ACEE_09565 ENOG4105VRX Protein slyX homolog ACEE_09570 ENOG4108V1T peptidylprolyl cis-trans isomerase ACEE_09575 ENOG4105WWK YheO domain protein ACEE_09580 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) ACEE_09585 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ACEE_09625 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ACEE_09630 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ACEE_09635 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ACEE_09640 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ACEE_09650 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ACEE_09665 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ACEE_09670 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ACEE_09675 ENOG410667J hydrolase ACEE_09685 ENOG4105F3R pts system mannose fructose sorbose family iid ACEE_09690 ENOG4105ETZ PTS System ACEE_09695 ENOG4108EQA pts system ACEE_09700 ENOG4105C6Z Gluconate ACEE_09705 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ACEE_09710 ENOG4105DIQ Transcriptional regulator ACEE_09715 ENOG4105ETE Transcriptional regulator (LacI family ACEE_09720 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ACEE_09730 ENOG4105CNN ABC, transporter ACEE_09735 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ACEE_09740 ENOG4108RVA ribokinase ACEE_09750 ENOG4105EAB amino acid AbC transporter ACEE_09755 ENOG4105E5Q amino acid AbC transporter ACEE_09760 ENOG4105CDA abc transporter atp-binding protein ACEE_09770 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ACEE_09775 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ACEE_09780 ENOG4105CJN penicillin-binding protein ACEE_09785 ENOG4105CNI cell division protein FtsW ACEE_09795 ENOG4105DZ1 carboxypeptidase ACEE_09805 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ACEE_09810 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ACEE_09825 ENOG4107QM2 Aldo Keto reductase ACEE_09830 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction ACEE_09835 ENOG4105C2I pirin domain protein ACEE_09840 ENOG4105VUC UPF0237 protein ACEE_09855 ENOG4105CEM UPF0597 protein ACEE_09870 ENOG4108V1T peptidylprolyl cis-trans isomerase ACEE_09875 ENOG41066VF YeeE YedE family protein ACEE_09880 ENOG4105KSU Redox protein ACEE_09885 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase ACEE_09890 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase ACEE_09920 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ACEE_09935 ENOG4105CT1 (ABC) transporter ACEE_09940 ENOG4105CDA abc transporter atp-binding protein ACEE_09950 ENOG4105E5Q amino acid AbC transporter ACEE_09955 ENOG4105R3P Inner membrane protein yagU ACEE_09965 ENOG4105EHG Permease protein ACEE_09970 ENOG4107R4I Periplasmic binding protein ACEE_09995 ENOG4105CXY transporter ACEE_10000 ENOG4105D98 threonine synthase ACEE_10005 ENOG4105EM2 membrane ACEE_10025 ENOG4105DWT malate dehydrogenase (quinone) ACEE_10030 ENOG4105DMF Dehydrogenase ACEE_10045 ENOG4105WBD 4-oxalocrotonate tautomerase ACEE_10055 ENOG4105CXY transporter ACEE_10060 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACEE_10065 ENOG4108HWV )-transporter ACEE_10070 ENOG4105C2J ABC transporter ACEE_10075 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator ACEE_10085 ENOG4105C94 Transporter ACEE_10090 ENOG4105CKD glutathione-regulated potassium-efflux system protein ACEE_10105 ENOG4105DQ4 alcohol dehydrogenase ACEE_10110 ENOG4108RCM Nitroreductase ACEE_10150 ENOG410863D Flavinator of succinate dehydrogenase ACEE_10160 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ACEE_10165 ENOG4108YZA Nitrogen regulatory protein pii ACEE_10175 ENOG4108RIR Molybdenum cofactor biosynthesis protein ACEE_10180 ENOG4108M1T Cytochrome c-type biogenesis protein ACEE_10185 ENOG4108M1T Cytochrome c-type biogenesis protein ACEE_10195 ENOG4107QX9 Thiol disulfide interChange protein ACEE_10200 ENOG4105CS9 pantothenic acid kinase ACEE_10225 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ACEE_10245 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ACEE_10255 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ACEE_10260 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ACEE_10275 ENOG4105CQB FAD linked oxidase domain protein ACEE_10280 ENOG4105KA0 thioesterase Superfamily protein ACEE_10300 ENOG4105QTB Flavodoxin ACEE_10305 ENOG4105CMG Carbohydrate kinase ACEE_10310 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ACEE_10315 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ACEE_10320 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ACEE_10325 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter ACEE_10330 ENOG4108R66 Conserved Protein ACEE_10335 ENOG4105DG4 malate L-lactate dehydrogenase ACEE_10340 ENOG4105MJ9 esterase ACEE_10350 ENOG4105D4P Coproporphyrinogen iii oxidase ACEE_10355 ENOG4108K3A Glutathione S-transferase ACEE_10360 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ACEE_10375 ENOG4105DKW ABC transporter ACEE_10390 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ACEE_10395 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ACEE_10400 ENOG4108RR8 protoporphyrinogen oxidase ACEE_10405 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ACEE_10425 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ACEE_10435 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ACEE_10440 ENOG4105CEN a g-specific adenine glycosylase ACEE_10445 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) ACEE_10450 ENOG4105E4C Lytic transglycosylase catalytic ACEE_10475 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ACEE_10480 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ACEE_10485 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ACEE_10500 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ACEE_10510 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) ACEE_10515 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ACEE_10520 ENOG4105E33 succinate dehydrogenase ACEE_10525 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ACEE_10530 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ACEE_10535 ENOG4105DYS nad(p)h dehydrogenase (quinone) ACEE_10550 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACEE_10555 ENOG4108BGM Quinol dehydrogenase periplasmic component ACEE_10560 ENOG4105GXZ Ferredoxin-type protein NapH ACEE_10565 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) ACEE_10570 ENOG4105CUW cytochrome C-TYPE protein ACEE_10575 ENOG4105D4A Cell wall formation (By similarity) ACEE_10580 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ACEE_10585 ENOG4105KZW UPF0381 protein ACEE_10590 ENOG4105CIC tryptophan-specific transport protein ACEE_10600 ENOG4105D9M gamma-glutamylcysteine synthetase ACEE_10605 ENOG4105DJ4 phosphatidylserine decarboxylase ACEE_10610 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ACEE_10615 ENOG4108UBT opacity-associated protein ACEE_10625 ENOG4105XA0 heptosyltransferase ii ACEE_10630 ENOG4105D16 lipopolysaccharide heptosyltransferase i ACEE_10635 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ACEE_10640 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ACEE_10645 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ACEE_10650 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ACEE_10655 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ACEE_10660 ENOG4108R96 Methyltransferase, YaeB family ACEE_10670 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ACEE_10680 ENOG4108YZY peptidylprolyl cis-trans isomerase ACEE_10685 ENOG4105C7B Threonine dehydratase ACEE_10690 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ACEE_10695 ENOG4105E66 phosphoriboisomerase A ACEE_10700 ENOG4108JQ1 Dehydrogenase ACEE_10705 ENOG4105NXV High-affinity zinc uptake system protein ACEE_10710 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ACEE_10715 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase ACEE_10725 ENOG4105C03 ribonuclease ACEE_10745 ENOG4107YB6 acetyltransferase, (GNAT) family ACEE_10750 ENOG4105MYG DNA polymerase iii, chi subunit ACEE_10755 ENOG4108WZM domain protein ACEE_10760 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ACEE_10765 ENOG4107YZP Rhodanese domain protein ACEE_10770 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) ACEE_10775 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ACEE_10780 ENOG4105D7W serine acetyltransferase ACEE_10785 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ACEE_10800 ENOG4105ER6 polysaccharide biosynthesis protein ACEE_10805 ENOG4105D5D udp-galactopyranose mutase ACEE_10815 ENOG4105KPE licD family ACEE_10820 ENOG4105CG5 Glycosyl transferase (Group 1 ACEE_10825 ENOG4108SHN Glycosyl transferase, family 2 ACEE_10830 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ACEE_10835 ENOG4105EJJ Dehydrogenase ACEE_10845 ENOG4105D3Q Sugar transferase ACEE_10855 ENOG4105C1B dTDP-glucose 4-6-dehydratase ACEE_10860 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ACEE_10865 ENOG4105VCC 30S ribosomal protein S21 ACEE_10870 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ACEE_10875 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACEE_10880 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ACEE_10885 ENOG4105CA0 peroxidase ACEE_10895 ENOG4108VIA integral membrane protein ACEE_10900 ENOG41090ED Protein with unknown function (DUF469) ACEE_10905 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ACEE_10910 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ACEE_10915 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ACEE_10920 ENOG4105VGS 50s ribosomal protein l32 ACEE_10925 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ACEE_10930 ENOG4106KVJ cytochrome C assembly protein ACEE_10935 ENOG4108JU6 CBS domain protein ACEE_10940 ENOG4105C8J )-transporter ACEE_10950 ENOG4108EQA pts system ACEE_10955 ENOG4105ETZ PTS System ACEE_10960 ENOG4105F3R pts system mannose fructose sorbose family iid ACEE_10965 ENOG4108NK4 UPF0266 membrane protein ACEE_10970 ENOG4105EIP mannose-6-phosphate isomerase ACEE_10980 ENOG4105C4Y ABC transporter ACEE_10985 ENOG4107RCV ABC transporter, permease ACEE_10990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACEE_11000 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ACEE_11010 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ACEE_11015 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ACEE_11020 ENOG4105EJ2 Transcriptional regulator ACEE_11025 ENOG4105C5Q Transcriptional regulator ACEE_11030 ENOG4105EHV domain protein ACEE_11040 ENOG4105DFU Cell wall formation (By similarity) ACEE_11045 ENOG4105C4W S-formylglutathione hydrolase ACEE_11060 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ACEE_11065 ENOG4105DZR Type I site-specific deoxyribonuclease ACEE_11075 ENOG4105EKX Restriction modification system DNA (Specificity ACEE_11085 ENOG4105D9Q decarboxylase (Beta subunit) ACEE_11090 ENOG4107QSA Oxaloacetate decarboxylase ACEE_11135 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) ACEE_11140 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ACEE_11145 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ACEE_11150 ENOG41060IM Heme exporter protein ACEE_11155 ENOG4105X3C heme exporter protein ACEE_11165 ENOG4105DA4 cytochrome c-type biogenesis protein ACEE_11185 ENOG4105CJP fad dependent oxidoreductase ACEE_11200 ENOG4105W4M Transport-associated protein ACEE_11205 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ACEE_11210 ENOG41082RQ UPF0102 protein ACEE_11215 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) ACEE_11220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ACEE_11225 ENOG4108BPE -transporting atpase ACEE_11230 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ACEE_11240 ENOG4105KDP XRE family ACEE_11250 ENOG4108V1U phospholipid-binding protein ACEE_11255 ENOG4105E5Z arginine transporter ATP-binding subunit ACEE_11260 ENOG4106PMH Extracellular solute-binding protein family 3 ACEE_11265 ENOG4105GBT ABC transporter ACEE_11270 ENOG4105DMR ABC, transporter ACEE_11280 ENOG4107UWN reductase ACEE_11285 ENOG4105XW2 UPF0263 protein ACEE_11290 ENOG4106H78 methyltransferase ACEE_11295 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ACEE_11300 ENOG4105CAK Cell division ATP-binding protein ftsE ACEE_11305 ENOG4105CRP Part of the ABC transporter FtsEX involved in ACEE_11325 ENOG4105MJ2 Competence protein ACEE_11330 ENOG4105CR8 Transcriptional regulator ACEE_11335 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ACEE_11345 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ACEE_11350 ENOG4105C1J atp-dependent rna helicase ACEE_11360 ENOG4105DEF Extracellular solute-binding protein, family 5 ACEE_11365 ENOG4106HK8 GPR1 FUN34 yaaH family protein ACEE_11370 ENOG4107RUE extracellular solute-binding protein family 1 ACEE_11375 ENOG4105E0A ABC, transporter ACEE_11385 ENOG4105S6R Iron-hydroxamate transporter permease subunit ACEE_11400 ENOG4105C8V SAICAR synthetase ACEE_11405 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ACEE_11410 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ACEE_11415 ENOG4105CIH Imidazole acetol-phosphate transaminase ACEE_11420 ENOG4108RS6 transposase ACEE_11435 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ACEE_11455 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ACEE_11460 ENOG4105EX9 Membrane ACEE_11465 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ACEE_11470 ENOG4105C4R Atp-dependent dna helicase ACEE_11480 ENOG4105D60 lipoprotein releasing system transmembrane protein ACEE_11485 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ACEE_11490 ENOG4105D60 lipoprotein releasing system transmembrane protein ACEE_11495 ENOG4105C5I Dehydrogenase ACEE_11505 ENOG41063JG Transcriptional regulator ACEE_11510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)