locus-tag	class	description
D1111_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1111_00010	COG0592	DNA-directed DNA polymerase activity
D1111_00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1111_00040	COG0616	signal peptide processing
D1111_00055	COG3116	cell division
D1111_00060	COG0768	penicillin binding
D1111_00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1111_00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1111_00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1111_00085	COG0772	Belongs to the SEDS family
D1111_00090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1111_00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1111_00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1111_00110	COG0849	cell division
D1111_00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1111_00120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D1111_00125	COG0497	DNA recombination
D1111_00135	COG4172	Belongs to the ABC transporter superfamily
D1111_00140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1111_00145	COG0601	transmembrane transport
D1111_00170	COG0193	aminoacyl-tRNA hydrolase activity
D1111_00175	COG0012	GTP binding
D1111_00180	COG2020	methyltransferase activity
D1111_00190	COG3133	Outer membrane lipoprotein
D1111_00195	COG3102	Protein conserved in bacteria
D1111_00200	COG0018	arginyl-trna synthetase
D1111_00215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1111_00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1111_00225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1111_00230	COG0196	riboflavin kinase activity
D1111_00235	COG3172	ATPase kinase involved in NAD metabolism
D1111_00240	COG2129	metallophosphoesterase
D1111_00245	COG0745	RESPONSE REGULATOR receiver
D1111_00255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1111_00260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1111_00270	COG1217	gtp-binding protein TYPA
D1111_00275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1111_00280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1111_00285	COG1561	YicC-like family, N-terminal region
D1111_00290	COG0354	folic acid binding
D1111_00295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1111_00300	COG2197	response regulator
D1111_00310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1111_00355	COG0747	negative chemotaxis
D1111_00360	COG0747	negative chemotaxis
D1111_00365	COG0601	transmembrane transport
D1111_00370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1111_00375	COG0444	Belongs to the ABC transporter superfamily
D1111_00380	COG4608	Belongs to the ABC transporter superfamily
D1111_00395	COG0251	oxidation-reduction process
D1111_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1111_00405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1111_00410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1111_00415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1111_00420	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D1111_00425	COG0848	biopolymer transport protein
D1111_00430	COG0811	peptide transport
D1111_00440	COG3118	belongs to the thioredoxin family
D1111_00445	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D1111_00445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1111_00445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1111_00450	COG1461	Dihydroxyacetone kinase
D1111_00455	COG2376	Dihydroxyacetone kinase
D1111_00460	COG0492	ferredoxin-NADP+ reductase activity
D1111_00465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D1111_00470	COG3753	Protein conserved in bacteria
D1111_00490	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1111_00495	COG0006	proline dipeptidase activity
D1111_00505	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D1111_00525	COG0129	dihydroxy-acid dehydratase activity
D1111_00530	COG3978	acetolactate synthase activity
D1111_00545	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D1111_00550	COG0437	4 iron, 4 sulfur cluster binding
D1111_00555	COG3301	Polysulphide reductase, NrfD
D1111_00560	COG5295	Hep Hag repeat protein
D1111_00560	COG5295	Hep Hag repeat protein
D1111_00560	COG5295	Hep Hag repeat protein
D1111_00560	COG5295	Hep Hag repeat protein
D1111_00575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1111_00580	COG1414	Transcriptional regulator
D1111_00585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1111_00595	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D1111_00605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1111_00610	COG3068	Protein conserved in bacteria
D1111_00635	COG1278	Cold shock
D1111_00640	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D1111_00645	COG0793	Belongs to the peptidase S41A family
D1111_00650	COG2989	Protein conserved in bacteria
D1111_00655	COG3108	Peptidase M15
D1111_00660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1111_00675	COG0537	adenosine 5'-monophosphoramidase activity
D1111_00680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1111_00685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1111_00695	COG1162	GTPase activity
D1111_00700	COG0583	DNA-binding transcription factor activity
D1111_00705	COG1011	Hydrolase
D1111_00710	COG0583	DNA-binding transcription factor activity
D1111_00720	COG0252	asparaginase activity
D1111_00725	COG0504	CTP synthase activity
D1111_00730	COG5413	integral membrane protein
D1111_00745	COG3835	regulator
D1111_00750	COG2610	gluconate transmembrane transporter activity
D1111_00755	COG1929	Belongs to the glycerate kinase type-1 family
D1111_00760	COG1254	Belongs to the acylphosphatase family
D1111_00765	COG3593	DNA synthesis involved in DNA repair
D1111_00770	COG1611	Belongs to the LOG family
D1111_00775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1111_00785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1111_00790	COG0316	Belongs to the HesB IscA family
D1111_00790	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D1111_00795	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1111_00800	COG1805	sodium ion transport
D1111_00805	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1111_00810	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1111_00815	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1111_00820	COG2871	sodium ion transport
D1111_00825	COG1477	protein flavinylation
D1111_00830	COG2991	Protein conserved in bacteria
D1111_00835	COG0482	sulfurtransferase activity
D1111_00840	COG2814	Major facilitator Superfamily
D1111_00845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1111_00855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1111_00870	COG4657	Part of a membrane complex involved in electron transport
D1111_00875	COG2878	Part of a membrane complex involved in electron transport
D1111_00880	COG4656	Part of a membrane complex involved in electron transport
D1111_00890	COG4658	electron transport chain
D1111_00905	COG1560	Kdo2-lipid A biosynthetic process
D1111_00910	COG0402	S-adenosylhomocysteine deaminase activity
D1111_00915	COG4143	(ABC) transporter
D1111_00920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1111_00925	COG0617	tRNA 3'-terminal CCA addition
D1111_00930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1111_00940	COG2911	Protein conserved in bacteria
D1111_00950	COG0346	lactoylglutathione lyase activity
D1111_00955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1111_00965	COG0287	Prephenate dehydrogenase
D1111_00965	COG1605	Chorismate mutase
D1111_00970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1111_00975	COG0859	PFAM glycosyl transferase family 9
D1111_00980	COG0469	pyruvate kinase activity
D1111_00985	COG2062	phosphohistidine phosphatase, SixA
D1111_00990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1111_00995	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D1111_01000	COG0733	neurotransmitter:sodium symporter activity
D1111_01005	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D1111_01010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1111_01015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1111_01020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1111_01025	COG4972	Pilus assembly protein
D1111_01045	COG4796	Type ii and iii secretion system protein
D1111_01050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1111_01055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1111_01060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D1111_01065	COG1280	lysine exporter protein (LysE YggA)
D1111_01070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1111_01080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1111_01095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1111_01150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1111_01155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1111_01160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1111_01175	COG1253	flavin adenine dinucleotide binding
D1111_01180	COG0564	pseudouridine synthase activity
D1111_01185	COG0588	phosphoglycerate mutase activity
D1111_01195	COG1678	Uncharacterized ACR, COG1678
D1111_01200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1111_01210	COG0271	Belongs to the BolA IbaG family
D1111_01245	COG0494	nUDIX hydrolase
D1111_01250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1111_01260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1111_01270	COG1629	transport
D1111_01270	COG4771	TonB-dependent receptor
D1111_01275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1111_01280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1111_01285	COG0083	homoserine kinase activity
D1111_01290	COG0460	homoserine dehydrogenase
D1111_01290	COG0527	aspartate kinase activity
D1111_01295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1111_01300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1111_01305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1111_01335	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1111_01340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1111_01345	COG0194	GDP metabolic process
D1111_01350	COG1538	Outer membrane efflux protein
D1111_01355	COG2914	Belongs to the UPF0125 (RnfH) family
D1111_01360	COG2867	negative regulation of translational initiation
D1111_01365	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1111_01370	COG4149	molybdate abc transporter
D1111_01375	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1111_01380	COG0842	Transport permease protein
D1111_01385	COG1131	(ABC) transporter
D1111_01390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1111_01395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1111_01405	COG0251	oxidation-reduction process
D1111_01410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1111_01415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1111_01420	COG1121	(ABC) transporter
D1111_01430	COG2920	part of a sulfur-relay system
D1111_01435	COG0670	Belongs to the BI1 family
D1111_01440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1111_01455	COG0084	hydrolase, TatD family'
D1111_01460	COG0210	DNA helicase
D1111_01465	COG3842	ATPase activity
D1111_01470	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1111_01475	COG1177	transmembrane transport
D1111_01480	COG0632	four-way junction helicase activity
D1111_01485	COG2255	four-way junction helicase activity
D1111_01490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1111_01495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1111_01545	COG0488	(ABC) transporter
D1111_01550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1111_01560	COG1271	oxidase subunit
D1111_01565	COG1294	oxidase, subunit
D1111_01580	COG0824	Thioesterase
D1111_01585	COG0811	peptide transport
D1111_01590	COG0848	biopolymer transport protein
D1111_01595	COG3064	Membrane
D1111_01595	COG3064	Membrane
D1111_01600	COG0823	Involved in the tonB-independent uptake of proteins
D1111_01615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1111_01620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1111_01630	COG0488	(ABC) transporter
D1111_01640	COG0303	'Molybdopterin
D1111_01645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1111_01660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1111_01670	COG0564	pseudouridine synthase activity
D1111_01675	COG3023	N-Acetylmuramoyl-L-alanine amidase
D1111_01680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1111_01685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1111_01690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1111_01695	COG0626	cystathionine gamma-synthase activity
D1111_01700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1111_01715	COG1702	phosphate starvation-inducible protein PhoH
D1111_01740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1111_01760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1111_01770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1111_01775	COG1137	ATPase activity
D1111_01780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D1111_01790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1111_01795	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D1111_01805	COG1704	LemA family
D1111_01815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1111_01815	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D1111_01815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1111_01820	COG1105	Belongs to the carbohydrate kinase PfkB family
D1111_01825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1111_01825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1111_01835	COG1523	belongs to the glycosyl hydrolase 13 family
D1111_01840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1111_01845	COG0297	glycogen (starch) synthase activity
D1111_01850	COG0058	SHG alpha-glucan phosphorylase activity
D1111_01880	COG1187	pseudouridine synthase activity
D1111_01885	COG2814	Major facilitator Superfamily
D1111_01895	COG3381	protein complex oligomerization
D1111_01905	COG0791	NLP P60 protein
D1111_01910	COG2932	Transcriptional regulator
D1111_01915	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D1111_01920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1111_01925	COG2990	Protein conserved in bacteria
D1111_01935	COG1643	Atp-dependent helicase
D1111_01940	COG2707	UPF0756 membrane protein
D1111_01945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1111_01950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1111_01955	COG0534	Mate efflux family protein
D1111_01960	COG1074	ATP-dependent DNA helicase activity
D1111_01965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1111_01970	COG4535	Mg2 and Co2 transporter CorC
D1111_01980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1111_01985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1111_01990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1111_01995	COG2271	Major facilitator Superfamily
D1111_02000	COG0584	glycerophosphoryl diester phosphodiesterase
D1111_02005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1111_02010	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
D1111_02015	COG0247	lactate metabolic process
D1111_02045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1111_02045	COG0517	IMP dehydrogenase activity
D1111_02055	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D1111_02060	COG0385	Bile acid
D1111_02065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1111_02070	COG0561	phosphatase activity
D1111_02080	COG1595	DNA-templated transcription, initiation
D1111_02085	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D1111_02095	COG0318	PFAM AMP-dependent synthetase and ligase
D1111_02100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1111_02105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1111_02110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1111_02115	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1111_02120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1111_02120	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1111_02125	COG1160	GTP binding
D1111_02130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1111_02135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1111_02150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1111_02155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1111_02170	COG0750	zinc metalloprotease
D1111_02175	COG0575	Belongs to the CDS family
D1111_02180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1111_02185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1111_02195	COG0671	phosphoesterase, PA-phosphatase related
D1111_02200	COG1534	Rna-binding protein
D1111_02205	COG0463	Glycosyl transferase, family 2
D1111_02210	COG1686	Belongs to the peptidase S11 family
D1111_02215	COG0859	PFAM glycosyl transferase family 9
D1111_02225	COG0328	RNA-DNA hybrid ribonuclease activity
D1111_02230	COG1286	toxin biosynthetic process
D1111_02235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1111_02245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1111_02250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1111_02260	COG0251	oxidation-reduction process
D1111_02265	COG1496	oxidoreductase activity
D1111_02275	COG5645	(Lipo)protein
D1111_02290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1111_02300	COG1792	Involved in formation and maintenance of cell shape
D1111_02305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D1111_02310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1111_02315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1111_02320	COG0121	glutamine amidotransferase
D1111_02325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1111_02330	COG2949	membrane
D1111_02340	COG1556	Lactate utilization protein
D1111_02345	COG1139	Iron-sulfur cluster binding protein
D1111_02350	COG0247	lactate metabolic process
D1111_02355	COG1620	l-lactate permease
D1111_02360	COG2916	Histone family protein nucleoid-structuring protein H-NS
D1111_02365	COG1757	Na H antiporter
D1111_02370	COG1879	ABC-type sugar transport system periplasmic component
D1111_02375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1111_02385	COG2990	Protein conserved in bacteria
D1111_02390	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1111_02395	COG0567	Dehydrogenase, E1 component
D1111_02400	COG1121	(ABC) transporter
D1111_02405	COG0739	heme binding
D1111_02410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1111_02415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1111_02430	COG3850	Histidine kinase
D1111_02440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1111_02445	COG0393	Putative heavy-metal-binding
D1111_02450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1111_02460	COG4221	oxidoreductase activity
D1111_02465	COG0133	tryptophan synthase activity
D1111_02485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1111_02485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1111_02490	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D1111_02500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1111_02505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1111_02530	COG0640	Transcriptional regulator
D1111_02540	COG0189	ligase activity
D1111_02545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1111_02550	COG0281	malic enzyme
D1111_02550	COG0280	phosphate acetyltransferase
D1111_02565	COG3683	transport system, periplasmic component
D1111_02570	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D1111_02575	COG1115	amino acid carrier protein
D1111_02580	COG1116	anion transmembrane transporter activity
D1111_02585	COG1116	anion transmembrane transporter activity
D1111_02590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1111_02595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1111_02600	COG2022	thiamine diphosphate biosynthetic process
D1111_02605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1111_02610	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1111_02615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1111_02620	COG0351	phosphomethylpyrimidine kinase
D1111_02630	COG0481	GTPase activity
D1111_02635	COG0681	Belongs to the peptidase S26 family
D1111_02640	COG0571	ribonuclease III activity
D1111_02645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1111_02730	COG0433	COG0433 Predicted ATPase
D1111_02745	COG1840	ABC-type Fe3 transport system, periplasmic component
D1111_02760	COG4178	(ABC) transporter
D1111_02770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1111_02775	COG2194	sulfuric ester hydrolase activity
D1111_02780	COG0528	UMP kinase activity
D1111_02785	COG0233	cytoplasmic translational termination
D1111_02790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1111_02805	COG0590	tRNA wobble adenosine to inosine editing
D1111_02810	COG0513	Belongs to the DEAD box helicase family
D1111_02815	COG4785	May be involved in cell division
D1111_02820	COG1185	polyribonucleotide nucleotidyltransferase activity
D1111_02825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1111_02840	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D1111_02855	COG3083	sulfuric ester hydrolase activity
D1111_02860	COG3082	Protein of unknown function (DUF1414)
D1111_02865	COG1309	transcriptional regulator
D1111_02870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1111_02875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1111_02890	COG3955	Domain of unknown function (DUF1919)
D1111_02895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1111_02910	COG0517	IMP dehydrogenase activity
D1111_02910	COG0516	GMP reductase activity
D1111_02915	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1111_02920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1111_02925	COG0814	amino acid
D1111_02930	COG0814	amino acid
D1111_02940	COG3105	Protein conserved in bacteria
D1111_02945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1111_02955	COG3022	response to hydroperoxide
D1111_02970	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D1111_02975	COG1823	symporter activity
D1111_02980	COG0778	Nitroreductase
D1111_02985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1111_02990	COG0072	phenylalanine-tRNA ligase activity
D1111_02995	COG0776	regulation of translation
D1111_03000	COG0791	NLP P60 protein
D1111_03010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1111_03015	COG1846	Transcriptional regulator
D1111_03015	COG1940	carbohydrate kinase activity
D1111_03020	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1111_03025	COG1522	sequence-specific DNA binding
D1111_03030	COG1674	ftsk spoiiie
D1111_03035	COG2321	neutral zinc metallopeptidase
D1111_03040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1111_03045	COG1214	PFAM Peptidase M22, glycoprotease
D1111_03050	COG1435	thymidine kinase activity
D1111_03055	COG3074	FtsZ-dependent cytokinesis
D1111_03060	COG1494	fructose-1,6-bisphosphatase
D1111_03065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1111_03070	COG0577	efflux transmembrane transporter activity
D1111_03070	COG1136	(ABC) transporter
D1111_03075	COG2205	protein histidine kinase activity
D1111_03080	COG0745	RESPONSE REGULATOR receiver
D1111_03085	COG3956	TIGRFAM MazG family protein
D1111_03095	COG0285	dihydrofolate synthase activity
D1111_03105	COG0779	Required for maturation of 30S ribosomal subunits
D1111_03110	COG0195	Participates in both transcription termination and antitermination
D1111_03115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1111_03120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1111_03125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1111_03130	COG2951	lytic endotransglycosylase activity
D1111_03140	COG0857	belongs to the CobB CobQ family
D1111_03140	COG0280	phosphate acetyltransferase
D1111_03150	COG0737	Belongs to the 5'-nucleotidase family
D1111_03170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1111_03180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D1111_03190	COG0589	response to stress
D1111_03200	COG2969	positive regulation of protein catabolic process
D1111_03205	COG0625	glutathione transferase activity
D1111_03210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1111_03220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1111_03225	COG1448	Aminotransferase
D1111_03230	COG0006	proline dipeptidase activity
D1111_03240	COG0556	nucleotide-excision repair
D1111_03250	COG2822	iron ion transport
D1111_03255	COG2837	iron assimilation
D1111_03265	COG0613	PHP domain protein
D1111_03275	COG2925	Exonuclease
D1111_03280	COG0038	chloride channel
D1111_03290	COG1509	lysine 2,3-aminomutase activity
D1111_03300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1111_03305	COG1476	TRANSCRIPTIONal
D1111_03320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1111_03325	COG2814	Major facilitator Superfamily
D1111_03330	COG0741	lytic transglycosylase activity
D1111_03335	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1111_03340	COG0626	cystathionine gamma-synthase activity
D1111_03345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1111_03355	COG2363	Small membrane protein
D1111_03360	COG0277	FAD linked oxidase domain protein
D1111_03365	COG0243	molybdopterin cofactor binding
D1111_03370	COG3005	denitrification pathway
D1111_03375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1111_03380	COG0315	cyclic pyranopterin monophosphate synthase activity
D1111_03385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D1111_03390	COG0314	molybdopterin synthase activity
D1111_03395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1111_03400	COG1444	tRNA N-acetyltransferase activity
D1111_03410	COG0583	DNA-binding transcription factor activity
D1111_03420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1111_03435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1111_03440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1111_03460	COG1737	Transcriptional regulator
D1111_03465	COG2731	YhcH YjgK YiaL family protein
D1111_03470	COG0248	Ppx GppA phosphatase
D1111_03480	COG0527	aspartate kinase activity
D1111_03485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1111_03490	COG3100	YcgL domain-containing protein
D1111_03495	COG0305	Participates in initiation and elongation during chromosome replication
D1111_03500	COG4607	ABC-type enterochelin transport system periplasmic component
D1111_03505	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1111_03510	COG4605	iron ion homeostasis
D1111_03515	COG4604	ABC transporter, ATP-binding protein
D1111_03520	COG1392	Phosphate transport regulator
D1111_03525	COG0306	phosphate transporter
D1111_03530	COG4991	sh3 domain protein
D1111_03540	COG3945	hemerythrin HHE cation binding domain
D1111_03545	COG0343	queuine tRNA-ribosyltransferase activity
D1111_03555	COG1278	Cold shock
D1111_03560	COG0288	reversible hydration of carbon dioxide
D1111_03565	COG0028	Belongs to the TPP enzyme family
D1111_03570	COG0440	acetolactate synthase activity
D1111_03575	COG0312	modulator of DNA gyrase
D1111_03580	COG3028	Belongs to the UPF0307 family
D1111_03585	COG3094	Invasion gene expression up-regulator, SirB
D1111_03595	COG1811	Na channel or pump
D1111_03600	COG3787	Belongs to the UPF0306 family
D1111_03605	COG0023	Translation Initiation Factor
D1111_03610	COG0284	orotidine-5'-phosphate decarboxylase activity
D1111_03615	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D1111_03620	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D1111_03625	COG0776	regulation of translation
D1111_03630	COG0539	negative regulation of cytoplasmic translation
D1111_03640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1111_03650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1111_03660	COG1785	Belongs to the alkaline phosphatase family
D1111_03665	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D1111_03675	COG3264	Mechanosensitive ion channel
D1111_03675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1111_03680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1111_03680	COG3264	Mechanosensitive ion channel
D1111_03685	COG0318	PFAM AMP-dependent synthetase and ligase
D1111_03690	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D1111_03695	COG0596	Alpha beta hydrolase
D1111_03705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1111_03725	COG1380	Effector of murein hydrolase LrgA
D1111_03730	COG1346	cytolysis
D1111_03745	COG3036	rescue of stalled ribosome
D1111_03750	COG2226	methyltransferase
D1111_03765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1111_03770	COG2333	competence protein COMEC
D1111_03770	COG0658	competence protein
D1111_03775	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D1111_03780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1111_03785	COG0737	Belongs to the 5'-nucleotidase family
D1111_03805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1111_03810	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1111_03815	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1111_03820	COG0167	dihydroorotate dehydrogenase activity
D1111_03825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1111_03840	COG1132	(ABC) transporter
D1111_03845	COG1346	cytolysis
D1111_03855	COG1199	ATP-dependent helicase activity
D1111_03865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1111_03870	COG0629	single-stranded DNA binding
D1111_03910	COG2070	2-Nitropropane dioxygenase
D1111_03920	COG2315	Protein conserved in bacteria
D1111_03925	COG4172	Belongs to the ABC transporter superfamily
D1111_03930	COG4171	peptide transport system, permease
D1111_03935	COG4168	peptide transport system, permease
D1111_03940	COG4166	transmembrane transport
D1111_03945	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D1111_03950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1111_03955	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1111_03960	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D1111_03980	COG1368	sulfuric ester hydrolase activity
D1111_03985	COG3217	Mosc domain protein beta barrel domain protein
D1111_03985	COG0633	Ferredoxin
D1111_03990	COG1722	exodeoxyribonuclease VII activity
D1111_03995	COG0142	geranyltranstransferase activity
D1111_04005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1111_04010	COG1530	ribonuclease E activity
D1111_04015	COG1944	ATP diphosphatase activity
D1111_04030	COG0500	methyltransferase
D1111_04040	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D1111_04060	COG2351	hydroxyisourate hydrolase activity
D1111_04070	COG0586	Pfam SNARE associated Golgi protein
D1111_04075	COG0187	DNA topoisomerase II activity
D1111_04080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1111_04085	COG1349	DNA-binding transcription factor activity
D1111_04090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1111_04095	COG2915	High frequency lysogenization protein hflD homolog
D1111_04100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D1111_04105	COG4988	ABC transporter
D1111_04110	COG2911	Protein conserved in bacteria
D1111_04115	COG0729	surface antigen
D1111_04120	COG2861	carbohydrate metabolic process
D1111_04125	COG4942	peptidase
D1111_04130	COG0588	phosphoglycerate mutase activity
D1111_04140	COG0572	uridine kinase
D1111_04145	COG0717	Belongs to the dCTP deaminase family
D1111_04150	COG1309	transcriptional regulator
D1111_04155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1111_04160	COG1129	ABC transporter
D1111_04160	COG0842	Transport permease protein
D1111_04165	COG0842	Transport permease protein
D1111_04175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1111_04180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1111_04185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1111_04195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1111_04200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1111_04205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1111_04210	COG4166	transmembrane transport
D1111_04220	COG0444	Belongs to the ABC transporter superfamily
D1111_04225	COG4608	Belongs to the ABC transporter superfamily
D1111_04235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1111_04245	COG0747	negative chemotaxis
D1111_04250	COG0814	amino acid
D1111_04255	COG1760	l-serine dehydratase
D1111_04260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1111_04260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1111_04265	COG0134	indole-3-glycerol-phosphate synthase activity
D1111_04265	COG0135	phosphoribosylanthranilate isomerase activity
D1111_04270	COG3177	Filamentation induced by cAMP protein fic
D1111_04275	COG3098	single-species biofilm formation
D1111_04280	COG0564	pseudouridine synthase activity
D1111_04285	COG3140	Belongs to the UPF0181 family
D1111_04295	COG3025	triphosphatase activity
D1111_04300	COG3106	COG3106 Predicted ATPase
D1111_04305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1111_04315	COG1473	amidohydrolase
D1111_04320	COG3069	C4-dicarboxylate transmembrane transporter activity
D1111_04325	COG3340	Belongs to the peptidase S51 family
D1111_04330	COG0495	leucyl-tRNA aminoacylation
D1111_04335	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D1111_04340	COG1466	dna polymerase III delta subunit
D1111_04345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1111_04350	COG0237	dephospho-CoA kinase activity
D1111_04365	COG2801	Transposase and inactivated derivatives
D1111_04375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1111_04380	COG4969	Belongs to the N-Me-Phe pilin family
D1111_04385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1111_04395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1111_04400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1111_04405	COG0730	response to heat
D1111_04410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1111_04415	COG0183	Belongs to the thiolase family
D1111_04420	COG1024	Enoyl-CoA hydratase
D1111_04420	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1111_04435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1111_04440	COG3383	formate dehydrogenase (NAD+) activity
D1111_04440	COG0243	molybdopterin cofactor binding
D1111_04445	COG3383	formate dehydrogenase (NAD+) activity
D1111_04445	COG0243	molybdopterin cofactor binding
D1111_04450	COG0437	4 iron, 4 sulfur cluster binding
D1111_04455	COG2864	formate dehydrogenase
D1111_04460	COG3058	Necessary for formate dehydrogenase activity
D1111_04490	COG1560	Kdo2-lipid A biosynthetic process
D1111_04495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1111_04505	COG0302	gtp cyclohydrolase
D1111_04510	COG3642	lipopolysaccharide core region biosynthetic process
D1111_04520	COG0110	maltose O-acetyltransferase activity
D1111_04550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1111_04560	COG0215	cysteine-tRNA ligase activity
D1111_04565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1111_04570	COG0617	tRNA 3'-terminal CCA addition
D1111_04600	COG2975	iron-sulfur cluster assembly
D1111_04605	COG0633	Ferredoxin
D1111_04625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1111_04635	COG0822	iron-sulfur transferase activity
D1111_04640	COG1104	cysteine desulfurase activity
D1111_04645	COG1959	2 iron, 2 sulfur cluster binding
D1111_04660	COG0784	Response regulator, receiver
D1111_04660	COG5002	protein histidine kinase activity
D1111_04660	COG2198	Histidine kinase
D1111_04665	COG0697	spore germination
D1111_04670	COG2840	Smr protein MutS2
D1111_04675	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1111_04680	COG2226	methyltransferase
D1111_04685	COG2830	Protein of unknown function (DUF452)
D1111_04690	COG0156	8-amino-7-oxononanoate synthase activity
D1111_04695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1111_04710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1111_04715	COG2027	D-alanyl-D-alanine carboxypeptidase
D1111_04750	COG1444	tRNA N-acetyltransferase activity
D1111_04755	COG0138	bifunctional purine biosynthesis protein purh
D1111_04775	COG3210	domain, Protein
D1111_04785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1111_04790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1111_04810	COG0786	glutamate:sodium symporter activity
D1111_04825	COG2350	Protein conserved in bacteria
D1111_04830	COG1607	acyl-coa hydrolase
D1111_04845	COG3092	negative regulation of chromosome organization
D1111_04850	COG0037	tRNA processing
D1111_04855	COG2056	Na+-H+ antiporter family
D1111_04860	COG0708	Exodeoxyribonuclease III
D1111_04865	COG0583	DNA-binding transcription factor activity
D1111_04885	COG0254	rRNA binding
D1111_04900	COG0753	catalase activity
D1111_04910	COG1408	metallophosphoesterase
D1111_04915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1111_04920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1111_04925	COG1085	galactose-1-phosphate uridylyltransferase
D1111_04935	COG2017	converts alpha-aldose to the beta-anomer
D1111_04970	COG0489	protein tyrosine kinase activity
D1111_04980	COG2095	MarC family integral membrane protein
D1111_04985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1111_04995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1111_05000	COG2354	Protein conserved in bacteria
D1111_05005	COG3071	HemY protein
D1111_05010	COG2959	enzyme of heme biosynthesis
D1111_05020	COG0181	hydroxymethylbilane synthase activity
D1111_05025	COG1012	belongs to the aldehyde dehydrogenase family
D1111_05025	COG1454	alcohol dehydrogenase
D1111_05040	COG0813	purine-nucleoside phosphorylase activity
D1111_05050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1111_05055	COG2364	Membrane
D1111_05060	COG0800	Aldolase
D1111_05065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1111_05070	COG1904	glucuronate isomerase
D1111_05085	COG2186	Transcriptional regulator
D1111_05095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1111_05095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1111_05100	COG1216	Glycosyl transferase, family 2
D1111_05105	COG1216	Glycosyl transferase, family 2
D1111_05115	COG3306	glycosyltransferase involved in LPS biosynthesis
D1111_05125	COG5039	Polysaccharide pyruvyl transferase
D1111_05130	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1111_05135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1111_05140	COG0077	Prephenate dehydratase
D1111_05140	COG1605	Chorismate mutase
D1111_05145	COG0339	signal peptide processing
D1111_05150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1111_05155	COG1882	Formate acetyltransferase
D1111_05160	COG2116	formate transmembrane transporter activity
D1111_05165	COG1238	metal cluster binding
D1111_05170	COG0501	Belongs to the peptidase M48B family
D1111_05175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1111_05180	COG2431	L-lysine efflux transmembrane transporter activity
D1111_05185	COG1169	isochorismate synthase
D1111_05190	COG0436	Aminotransferase
D1111_05195	COG2962	Rard protein
D1111_05200	COG2962	Rard protein
D1111_05205	COG1280	lysine exporter protein (LysE YggA)
D1111_05210	COG1629	transport
D1111_05210	COG4771	TonB-dependent receptor
D1111_05215	COG0748	coenzyme F420 binding
D1111_05225	COG4235	cytochrome complex assembly
D1111_05225	COG3088	subunit of a heme lyase
D1111_05230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1111_05235	COG1138	Cytochrome C-type biogenesis protein
D1111_05240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1111_05240	COG0475	glutathione-regulated potassium exporter activity
D1111_05250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1111_05260	COG3111	PFAM Bacterial OB fold (BOF) protein
D1111_05275	COG0745	RESPONSE REGULATOR receiver
D1111_05280	COG0642	Histidine kinase
D1111_05285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D1111_05290	COG1862	Preprotein translocase
D1111_05295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1111_05300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1111_05305	COG1528	Iron-storage protein
D1111_05310	COG1528	Iron-storage protein
D1111_05320	COG2252	PERMEase
D1111_05325	COG0424	maF-like protein
D1111_05335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1111_05335	COG0301	tRNA thio-modification
D1111_05345	COG0330	HflC and HflK could
D1111_05350	COG0330	HflC and HflK could
D1111_05355	COG3118	belongs to the thioredoxin family
D1111_05375	COG0531	amino acid
D1111_05380	COG0531	amino acid
D1111_05395	COG3047	cAMP biosynthetic process
D1111_05400	COG0542	response to heat
D1111_05405	COG0798	PFAM Bile acid sodium symporter
D1111_05410	COG1393	Belongs to the ArsC family
D1111_05420	COG1027	Aspartate ammonia-lyase
D1111_05430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1111_05445	COG0720	synthase
D1111_05450	COG0602	queuosine metabolic process
D1111_05475	COG0795	lipopolysaccharide-transporting ATPase activity
D1111_05480	COG0795	lipopolysaccharide-transporting ATPase activity
D1111_05525	COG0861	Integral membrane protein TerC family
D1111_05530	COG1472	Belongs to the glycosyl hydrolase 3 family
D1111_05535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1111_05540	COG0148	phosphopyruvate hydratase activity
D1111_05545	COG1051	belongs to the nudix hydrolase family
D1111_05550	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
D1111_05560	COG1965	Belongs to the frataxin family
D1111_05575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1111_05580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1111_05585	COG0564	pseudouridine synthase activity
D1111_05595	COG0205	6-phosphofructokinase activity
D1111_05600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1111_05605	COG1525	nuclease
D1111_05610	COG1115	amino acid carrier protein
D1111_05615	COG0628	permease
D1111_05625	COG0826	peptidase U32
D1111_05630	COG3307	-O-antigen
D1111_05635	COG1519	Transferase
D1111_05645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1111_05650	COG0802	atpase or kinase
D1111_05655	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1111_05655	COG1388	LysM domain
D1111_05660	COG0166	Belongs to the GPI family
D1111_05665	COG2960	long-chain fatty acid transporting porin activity
D1111_05690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1111_05700	COG0551	DNA topoisomerase type I activity
D1111_05710	COG2137	regulation of response to DNA damage stimulus
D1111_05715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1111_05720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1111_05730	COG1322	Protein conserved in bacteria
D1111_05735	COG0512	Glutamine amidotransferase of anthranilate synthase
D1111_05750	COG0494	nUDIX hydrolase
D1111_05755	COG0217	transcriptional regulatory protein
D1111_05765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1111_05770	COG0612	Peptidase, M16
D1111_05785	COG0583	DNA-binding transcription factor activity
D1111_05790	COG3266	domain, Protein
D1111_05795	COG1187	pseudouridine synthase activity
D1111_05800	COG0009	L-threonylcarbamoyladenylate synthase
D1111_05810	COG2837	iron assimilation
D1111_05815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1111_05820	COG0512	Glutamine amidotransferase of anthranilate synthase
D1111_05830	COG2226	methyltransferase
D1111_05835	COG2268	Band 7 protein
D1111_05840	COG2841	Protein conserved in bacteria
D1111_05845	COG0359	binds to the 23S rRNA
D1111_05855	COG2965	DNA replication, synthesis of RNA primer
D1111_05870	COG3201	nicotinamide mononucleotide transporter
D1111_05875	COG2976	Protein conserved in bacteria
D1111_05885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1111_05890	COG1426	Protein conserved in bacteria
D1111_05895	COG0659	secondary active sulfate transmembrane transporter activity
D1111_05910	COG0673	inositol 2-dehydrogenase activity
D1111_05915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1111_05915	COG0475	glutathione-regulated potassium exporter activity
D1111_05955	COG1902	pentaerythritol trinitrate reductase activity
D1111_05960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1111_05965	COG2084	Dehydrogenase
D1111_05970	COG0778	Nitroreductase
D1111_05975	COG2095	MarC family integral membrane protein
D1111_05985	COG0625	glutathione transferase activity
D1111_06005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1111_06020	COG1275	C4-dicarboxylate transporter malic acid transport protein
D1111_06025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1111_06040	COG1132	(ABC) transporter
D1111_06045	COG1854	S-ribosylhomocysteine lyase activity
D1111_06050	COG3008	intermembrane lipid transfer
D1111_06055	COG0735	belongs to the Fur family
D1111_06060	COG0716	FMN binding
D1111_06070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1111_06075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1111_06080	COG2252	PERMEase
D1111_06085	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1111_06090	COG2081	HI0933 family
D1111_06095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1111_06105	COG0560	Phosphoserine phosphatase
D1111_06110	COG1666	GTP binding
D1111_06120	COG0058	SHG alpha-glucan phosphorylase activity
D1111_06125	COG2909	trisaccharide binding
D1111_06135	COG4580	involved in the transport of maltose and maltodextrins
D1111_06140	COG3842	ATPase activity
D1111_06155	COG3833	ABC-type maltose transport systems, permease component
D1111_06160	COG1640	4-alpha-glucanotransferase
D1111_06165	COG1966	Carbon starvation protein
D1111_06170	COG0084	hydrolase, TatD family'
D1111_06175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1111_06185	COG0778	Nitroreductase
D1111_06200	COG4172	Belongs to the ABC transporter superfamily
D1111_06205	COG0191	fructose-bisphosphate aldolase activity
D1111_06210	COG0126	phosphoglycerate kinase activity
D1111_06215	COG0471	metal ion transport
D1111_06220	COG0471	metal ion transport
D1111_06225	COG0471	metal ion transport
D1111_06230	COG0187	DNA topoisomerase II activity
D1111_06235	COG5002	protein histidine kinase activity
D1111_06240	COG0745	RESPONSE REGULATOR receiver
D1111_06265	COG0789	Transcriptional regulator
D1111_06275	COG2217	Heavy metal translocating P-type atpase
D1111_06285	COG0300	oxidoreductase activity
D1111_06290	COG0778	Nitroreductase
D1111_06295	COG0616	signal peptide processing
D1111_06300	COG3719	Belongs to the RNase T2 family
D1111_06310	COG1252	NADH dehydrogenase
D1111_06315	COG2183	response to ionizing radiation
D1111_06320	COG3063	Type IV pilus biogenesis stability protein PilW
D1111_06360	COG2161	toxin-antitoxin pair type II binding
D1111_06365	COG4115	mRNA cleavage
D1111_06370	COG2835	tetraacyldisaccharide 4'-kinase activity
D1111_06375	COG1663	tetraacyldisaccharide 4'-kinase activity
D1111_06380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1111_06385	COG0740	serine-type endopeptidase activity
D1111_06390	COG2166	iron-sulfur cluster assembly
D1111_06410	COG0488	(ABC) transporter
D1111_06415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1111_06430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1111_06435	COG5007	Belongs to the BolA IbaG family
D1111_06445	COG2854	intermembrane phospholipid transfer
D1111_06450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1111_06455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1111_06460	COG1127	ABC transporter
D1111_06465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1111_06470	COG1090	epimerase
D1111_06490	COG0563	adenylate kinase activity
D1111_06500	COG2814	Major facilitator Superfamily
D1111_06530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1111_06550	COG3759	membrane
D1111_06560	COG2814	Major facilitator Superfamily
D1111_06565	COG0363	glucosamine-6-phosphate deaminase activity
D1111_06570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1111_06575	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1111_06580	COG0494	nUDIX hydrolase
D1111_06585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1111_06595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1111_06605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1111_06610	COG0549	Belongs to the carbamate kinase family
D1111_06620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D1111_06625	COG1178	ABC-type Fe3 transport system permease component
D1111_06630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1111_06635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1111_06640	COG2190	(PTS) system
D1111_06645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1111_06650	COG0210	DNA helicase
D1111_06655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1111_06660	COG0409	Hydrogenase expression formation protein
D1111_06665	COG0309	Hydrogenase expression formation protein (HypE)
D1111_06670	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D1111_06675	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D1111_06680	COG0437	4 iron, 4 sulfur cluster binding
D1111_06685	COG5557	Pfam Polysulphide reductase, NrfD
D1111_06690	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D1111_06695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D1111_06700	COG1773	rubredoxin
D1111_06705	COG0298	carbon dioxide binding
D1111_06710	COG0375	protein maturation
D1111_06745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1111_06750	COG0308	aminopeptidase N
D1111_06755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1111_06760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1111_06765	COG0295	cytidine deaminase activity
D1111_06770	COG2177	Part of the ABC transporter FtsEX involved in
D1111_06775	COG2884	Cell division ATP-binding protein ftsE
D1111_06780	COG0552	protein localization to endoplasmic reticulum
D1111_06785	COG0742	ribosomal rna small subunit methyltransferase
D1111_06790	COG3099	Belongs to the UPF0263 family
D1111_06795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1111_06805	COG4160	amino acid transport
D1111_06810	COG4215	(ABC) transporter
D1111_06815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1111_06820	COG1126	abc transporter atp-binding protein
D1111_06825	COG1881	PFAM PEBP family protein
D1111_06835	COG3620	sequence-specific DNA binding
D1111_06845	COG4232	protein-disulfide reductase activity
D1111_06850	COG3101	peptidyl-lysine hydroxylation
D1111_06860	COG3107	peptidoglycan biosynthetic process
D1111_06865	COG0792	nuclease activity
D1111_06870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1111_06900	COG1138	Cytochrome C-type biogenesis protein
D1111_06910	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1111_06915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1111_06920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1111_06925	COG4133	protoheme IX ABC transporter activity
D1111_06930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1111_06970	COG3630	sodium ion export across plasma membrane
D1111_06980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D1111_06985	COG2824	Alkylphosphonate utilization operon protein PhnA
D1111_06990	COG1858	cytochrome C peroxidase
D1111_07000	COG0762	integral membrane protein
D1111_07005	COG3171	Protein conserved in bacteria
D1111_07010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1111_07015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1111_07020	COG0416	fatty acid biosynthetic process
D1111_07025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1111_07030	COG1399	metal-binding, possibly nucleic acid-binding protein
D1111_07035	COG4137	Cytochrome C assembly protein
D1111_07040	COG4536	flavin adenine dinucleotide binding
D1111_07045	COG0733	neurotransmitter:sodium symporter activity
D1111_07055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1111_07055	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1111_07060	COG3715	PTS system
D1111_07065	COG3716	PTS system mannose fructose sorbose family IID component
D1111_07100	COG1840	ABC-type Fe3 transport system, periplasmic component
D1111_07115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1111_07130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1111_07135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1111_07140	COG0049	tRNA binding
D1111_07145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1111_07150	COG0859	PFAM glycosyl transferase family 9
D1111_07155	COG0859	PFAM glycosyl transferase family 9
D1111_07165	COG3266	domain, Protein
D1111_07165	COG3061	Opacity-associated protein A
D1111_07170	COG1555	photosystem II stabilization
D1111_07195	COG0732	type I restriction modification DNA specificity domain
D1111_07200	COG4974	Belongs to the 'phage' integrase family
D1111_07220	COG0814	amino acid
D1111_07225	COG3691	Protein conserved in bacteria
D1111_07230	COG4989	oxidoreductase activity
D1111_07235	COG1022	Amp-dependent synthetase and ligase
D1111_07260	COG4211	Belongs to the binding-protein-dependent transport system permease family
D1111_07265	COG1129	ABC transporter
D1111_07270	COG1879	ABC-type sugar transport system periplasmic component
D1111_07280	COG0277	FAD linked oxidase domain protein
D1111_07280	COG0247	lactate metabolic process
D1111_07285	COG2050	protein possibly involved in aromatic compounds catabolism
D1111_07295	COG3005	denitrification pathway
D1111_07300	COG3043	anaerobic respiration
D1111_07305	COG0348	domain, Protein
D1111_07310	COG0437	4 iron, 4 sulfur cluster binding
D1111_07315	COG0243	molybdopterin cofactor binding
D1111_07325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1111_07330	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1111_07345	COG1530	ribonuclease E activity
D1111_07355	COG1755	Isoprenylcysteine carboxyl methyltransferase
D1111_07365	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D1111_07380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1111_07385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1111_07390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1111_07405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1111_07415	COG1720	tRNA m6t6A37 methyltransferase activity
D1111_07425	COG1575	Belongs to the MenA family. Type 1 subfamily
D1111_07435	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D1111_07440	COG1088	dTDP-glucose 4,6-dehydratase activity
D1111_07465	COG1215	transferase activity, transferring glycosyl groups
D1111_07485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1111_07490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1111_07500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1111_07505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1111_07515	COG0557	exoribonuclease II activity
D1111_07520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1111_07525	COG1309	transcriptional regulator
D1111_07530	COG0583	DNA-binding transcription factor activity
D1111_07535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1111_07535	COG0678	peroxiredoxin activity
D1111_07545	COG2801	Transposase and inactivated derivatives
D1111_07570	COG0825	malonyl-CoA metabolic process
D1111_07580	COG0204	Acyl-transferase
D1111_07585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D1111_07610	COG0783	Belongs to the Dps family
D1111_07625	COG1289	transmembrane transporter activity
D1111_07630	COG1803	Methylglyoxal synthase
D1111_07635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1111_07645	COG0525	valine-tRNA ligase activity
D1111_07655	COG2153	protein acetylation
D1111_07660	COG2927	DNA polymerase III (CHI subunit)
D1111_07665	COG1652	LysM domain
D1111_07675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1111_07680	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D1111_07685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1111_07690	COG1045	serine acetyltransferase
D1111_07695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1111_07725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1111_07740	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1111_07750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1111_07760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1111_07775	COG0625	glutathione transferase activity
D1111_07780	COG0019	diaminopimelate decarboxylase activity
D1111_07790	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D1111_07795	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D1111_07800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1111_07805	COG1053	succinate dehydrogenase
D1111_07810	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D1111_07815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1111_07820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1111_07825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1111_07835	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1111_07840	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1111_07845	COG2264	protein methyltransferase activity
D1111_07875	COG4974	Belongs to the 'phage' integrase family
D1111_07930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D1111_07945	COG1151	hydroxylamine reductase activity
D1111_07950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1111_07955	COG2244	polysaccharide biosynthetic process
D1111_07960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1111_07970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1111_07975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D1111_07980	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D1111_07990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1111_08000	COG0728	peptidoglycan biosynthetic process
D1111_08005	COG0268	Binds directly to 16S ribosomal RNA
D1111_08010	COG0569	domain protein
D1111_08015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1111_08020	COG3276	selenocysteine insertion sequence binding
D1111_08035	COG0716	FMN binding
D1111_08060	COG1629	transport
D1111_08060	COG4771	TonB-dependent receptor
D1111_08085	COG2431	L-lysine efflux transmembrane transporter activity
D1111_08100	COG3545	Serine hydrolase
D1111_08125	COG1215	transferase activity, transferring glycosyl groups
D1111_08125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1111_08155	COG1119	ATPase activity
D1111_08170	COG1739	Uncharacterized protein family UPF0029
D1111_08175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1111_08180	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D1111_08185	COG1970	mechanosensitive ion channel activity
D1111_08190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1111_08195	COG0321	lipoyl(octanoyl) transferase activity
D1111_08200	COG2921	Belongs to the UPF0250 family
D1111_08205	COG1686	Belongs to the peptidase S11 family
D1111_08210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1111_08215	COG0772	Belongs to the SEDS family
D1111_08220	COG0768	penicillin binding
D1111_08225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1111_08230	COG0799	negative regulation of ribosome biogenesis
D1111_08240	COG1126	abc transporter atp-binding protein
D1111_08245	COG0765	amino acid transport
D1111_08250	COG3681	Belongs to the UPF0597 family
D1111_08255	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D1111_08265	COG3691	Protein conserved in bacteria
D1111_08285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1111_08310	COG0832	Belongs to the urease beta subunit family
D1111_08315	COG0831	urea catabolic process
D1111_08325	COG1122	ATPase activity
D1111_08330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D1111_08335	COG0310	cobalt ion transport
D1111_08340	COG0310	cobalt ion transport
D1111_08345	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D1111_08350	COG0583	DNA-binding transcription factor activity
D1111_08360	COG0471	metal ion transport
D1111_08360	COG0490	domain, Protein
D1111_08365	COG3722	fumarate hydratase activity
D1111_08370	COG0246	Mannitol dehydrogenase
D1111_08380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1111_08385	COG1349	DNA-binding transcription factor activity
D1111_08400	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
D1111_08410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1111_08415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1111_08420	COG2900	Belongs to the SlyX family
D1111_08425	COG0545	Peptidyl-prolyl cis-trans isomerase
D1111_08430	COG2964	Protein conserved in bacteria
D1111_08435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1111_08445	COG2168	tRNA wobble position uridine thiolation
D1111_08475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1111_08480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1111_08490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1111_08520	COG0445	tRNA wobble uridine modification
D1111_08525	COG0561	phosphatase activity
D1111_08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1111_08535	COG3012	SEC-C Motif Domain Protein
D1111_08545	COG3716	PTS system mannose fructose sorbose family IID component
D1111_08550	COG3715	PTS system
D1111_08555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1111_08555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1111_08560	COG2610	gluconate transmembrane transporter activity
D1111_08565	COG3265	gluconokinase activity
D1111_08570	COG1609	Transcriptional regulator
D1111_08575	COG1609	Transcriptional regulator
D1111_08590	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1111_08595	COG1879	ABC-type sugar transport system periplasmic component
D1111_08600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1111_08605	COG0243	molybdopterin cofactor binding
D1111_08610	COG0437	4 iron, 4 sulfur cluster binding
D1111_08615	COG3302	dmso reductase anchor subunit
D1111_08620	COG3381	protein complex oligomerization
D1111_08625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1111_08625	COG2221	Nitrite and sulphite reductase 4Fe-4S
D1111_08650	COG1349	DNA-binding transcription factor activity
D1111_08655	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
D1111_08660	COG1070	Carbohydrate kinase
D1111_08665	COG4154	Belongs to the RbsD FucU family
D1111_08670	COG0235	Class ii aldolase
D1111_08675	COG0738	Major facilitator superfamily
D1111_08680	COG1454	alcohol dehydrogenase
D1111_08685	COG3477	response to acidic pH
D1111_08690	COG0765	amino acid transport
D1111_08700	COG1126	abc transporter atp-binding protein
D1111_08705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1111_08725	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D1111_08750	COG3623	hexulose-6-phosphate isomerase
D1111_08755	COG0235	Class ii aldolase
D1111_08760	COG0545	Peptidyl-prolyl cis-trans isomerase
D1111_08780	COG4783	chaperone-mediated protein folding
D1111_08785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1111_08795	COG0758	DNA mediated transformation
D1111_08800	COG1297	OPT oligopeptide transporter protein
D1111_08815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1111_08825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1111_08830	COG0081	regulation of translation
D1111_08835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1111_08840	COG0222	ribosome binding
D1111_08875	COG0085	RNA polymerase activity
D1111_08895	COG1487	ribonuclease activity
D1111_08920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1111_08930	COG0346	lactoylglutathione lyase activity
D1111_08935	COG1194	a g-specific adenine glycosylase
D1111_08940	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D1111_08945	COG0741	lytic transglycosylase activity
D1111_08970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1111_08975	COG0737	Belongs to the 5'-nucleotidase family
D1111_08980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1111_08985	COG0606	chelatase, subunit chli
D1111_08995	COG2267	carboxylic ester hydrolase activity
D1111_09000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D1111_09010	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D1111_09020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1111_09025	COG0363	glucosamine-6-phosphate deaminase activity
D1111_09030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1111_09045	COG0051	transcription antitermination factor activity, RNA binding
D1111_09050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1111_09055	COG0088	Forms part of the polypeptide exit tunnel
D1111_09060	COG0089	rRNA binding
D1111_09065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1111_09070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1111_09075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1111_09080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1111_09085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1111_09090	COG0255	Belongs to the universal ribosomal protein uL29 family
D1111_09095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1111_09105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1111_09110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1111_09115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1111_09120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1111_09125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1111_09130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1111_09135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1111_09140	COG1841	ribosomal large subunit assembly
D1111_09145	COG0200	Binds to the 23S rRNA
D1111_09150	COG0201	protein transport
D1111_09160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1111_09165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1111_09170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1111_09175	COG0202	RNA polymerase activity
D1111_09185	COG0228	four-way junction DNA binding
D1111_09190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1111_09195	COG0336	Belongs to the RNA methyltransferase TrmD family
D1111_09200	COG0335	large ribosomal subunit rRNA binding
D1111_09205	COG2850	peptidyl-arginine hydroxylation
D1111_09210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1111_09215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1111_09260	COG2852	Protein conserved in bacteria
D1111_09285	COG2832	Protein of unknown function (DUF454)
D1111_09295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1111_09305	COG0084	hydrolase, TatD family'
D1111_09325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1111_09335	COG0470	DNA polymerase III
D1111_09340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1111_09345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1111_09365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1111_09370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1111_09375	COG0254	rRNA binding
D1111_09380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1111_09385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1111_09390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1111_09395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1111_09405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1111_09430	COG1595	DNA-templated transcription, initiation
D1111_09435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1111_09445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1111_09470	COG2502	aspartate--ammonia ligase
D1111_09475	COG1522	sequence-specific DNA binding
D1111_09480	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D1111_09485	COG3161	chorismate lyase activity
D1111_09525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1111_09550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D1111_09560	COG4208	sulfate ABC transporter
D1111_09565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1111_09570	COG1304	FMN binding
D1111_09580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1111_09590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1111_09595	COG2995	paraquat-inducible protein a
D1111_09600	COG1305	Transglutaminase-like
D1111_09610	COG2608	mercury ion transmembrane transporter activity
D1111_09615	COG1979	alcohol dehydrogenase
D1111_09620	COG0583	DNA-binding transcription factor activity
D1111_09625	COG2171	N-acyltransferase activity
D1111_09630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1111_09640	COG0511	ligase activity, forming carbon-carbon bonds
D1111_09645	COG0439	Biotin carboxylase
D1111_09655	COG3084	Protein conserved in bacteria
D1111_09660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1111_09670	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1111_09670	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1111_09680	COG1876	peptidase activity
D1111_09685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1111_09690	COG1393	Belongs to the ArsC family
D1111_09700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1111_09705	COG0564	pseudouridine synthase activity
D1111_09715	COG0668	transmembrane transport
D1111_09720	COG0439	Biotin carboxylase
D1111_09730	COG1025	Belongs to the peptidase M16 family
D1111_09735	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D1111_09760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1111_09765	COG1067	ATP-dependent peptidase activity
D1111_09770	COG3120	sequence-specific DNA binding
D1111_09775	COG0180	Tryptophanyl-tRNA synthetase
D1111_09790	COG0730	response to heat
D1111_09805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1111_09815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1111_09820	COG2116	formate transmembrane transporter activity
D1111_09850	COG1070	Carbohydrate kinase
D1111_09855	COG2115	Belongs to the xylose isomerase family
D1111_09860	COG4213	ABC transporter substrate-binding protein
D1111_09865	COG1129	ABC transporter
D1111_09870	COG4214	carbohydrate transport
D1111_09875	COG1609	Transcriptional regulator
D1111_09875	COG2207	Transcriptional regulator
D1111_09880	COG3590	peptidase
D1111_09890	COG4145	pantothenate transmembrane transporter activity
D1111_09895	COG3924	membrane
D1111_09900	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D1111_09905	COG2853	Lipoprotein
D1111_09910	COG0676	glucose-6-phosphate 1-epimerase activity
D1111_09925	COG1649	PFAM Uncharacterised BCR, COG1649
D1111_09925	COG0726	polysaccharide deacetylase
D1111_09930	COG1215	transferase activity, transferring glycosyl groups
D1111_09940	COG0149	triose-phosphate isomerase activity
D1111_09950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1111_09955	COG1238	metal cluster binding
D1111_09970	COG4942	peptidase
D1111_09970	COG1388	LysM domain
D1111_09975	COG2818	Glycosylase
D1111_09985	COG0700	Nucleoside recognition
D1111_09990	COG3366	ferrous iron transmembrane transporter activity
D1111_09995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1111_10000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1111_10005	COG0594	ribonuclease P activity
D1111_10010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1111_10015	COG0174	glutamine synthetase
D1111_10020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1111_10025	COG0494	nUDIX hydrolase
D1111_10045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1111_10055	COG1490	D-aminoacyl-tRNA deacylase activity
D1111_10060	COG1295	ribonuclease BN
D1111_10100	COG1923	regulation of RNA biosynthetic process
D1111_10105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1111_10115	COG1694	Mazg nucleotide pyrophosphohydrolase
D1111_10130	COG1309	transcriptional regulator
D1111_10140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1111_10145	COG2003	Belongs to the UPF0758 family
D1111_10150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1111_10155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1111_10165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1111_10170	COG0076	glutamate decarboxylase activity
D1111_10175	COG0425	Belongs to the sulfur carrier protein TusA family
D1111_10180	COG2391	methyltransferase activity
D1111_10185	COG3085	chromosome segregation
D1111_10205	COG0598	Magnesium transport protein CorA
D1111_10210	COG2226	methyltransferase
D1111_10220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1111_10225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1111_10230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1111_10235	COG0805	protein transport
D1111_10255	COG1114	Component of the transport system for branched-chain amino acids
D1111_10260	COG1028	Short-chain dehydrogenase reductase Sdr
D1111_10265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1111_10270	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1111_10275	COG0142	geranyltranstransferase activity
D1111_10285	COG0431	NADPH-dependent FMN reductase
D1111_10290	COG2259	Doxx family
D1111_10295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1111_10300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1111_10305	COG0697	spore germination
D1111_10310	COG4783	chaperone-mediated protein folding
D1111_10320	COG1040	competence protein
D1111_10325	COG2813	Specifically methylates the guanine in position
D1111_10335	COG0456	acetyltransferase
D1111_10340	COG0513	Belongs to the DEAD box helicase family
D1111_10350	COG0747	negative chemotaxis
D1111_10360	COG1584	GPR1 FUN34 yaaH family protein
D1111_10365	COG1120	ATPase activity
D1111_10370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1111_10375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1111_10395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1111_10400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1111_10405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1111_10425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1111_10440	COG0140	phosphoribosyl-ATP diphosphatase activity
D1111_10440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1111_10445	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D1111_10450	COG0024	Methionine aminopeptidase
D1111_10465	COG1621	beta-fructofuranosidase activity
D1111_10470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1111_10480	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1111_10485	COG1136	(ABC) transporter
D1111_10490	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1111_10495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family