locus-tag	class	description
JS559_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JS559_00010	COG0592	DNA-directed DNA polymerase activity
JS559_00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JS559_00040	COG0616	signal peptide processing
JS559_00045	COG2001	Belongs to the MraZ family
JS559_00050	COG0275	rRNA processing
JS559_00055	COG3116	cell division
JS559_00060	COG0768	penicillin binding
JS559_00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JS559_00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JS559_00075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JS559_00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JS559_00085	COG0772	Belongs to the SEDS family
JS559_00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JS559_00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
JS559_00110	COG0849	cell division
JS559_00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JS559_00125	COG0497	DNA recombination
JS559_00130	COG4172	Belongs to the ABC transporter superfamily
JS559_00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS559_00140	COG0601	transmembrane transport
JS559_00170	COG0012	GTP binding
JS559_00175	COG2020	methyltransferase activity
JS559_00185	COG3133	Outer membrane lipoprotein
JS559_00190	COG3102	Protein conserved in bacteria
JS559_00195	COG0018	arginyl-trna synthetase
JS559_00200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JS559_00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JS559_00215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JS559_00220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JS559_00225	COG0196	riboflavin kinase activity
JS559_00230	COG3172	ATPase kinase involved in NAD metabolism
JS559_00235	COG2129	metallophosphoesterase
JS559_00240	COG0745	RESPONSE REGULATOR receiver
JS559_00250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JS559_00255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JS559_00260	COG1217	gtp-binding protein TYPA
JS559_00265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JS559_00270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JS559_00275	COG1561	YicC-like family, N-terminal region
JS559_00280	COG0354	folic acid binding
JS559_00285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JS559_00290	COG2197	response regulator
JS559_00300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JS559_00340	COG0747	negative chemotaxis
JS559_00345	COG0747	negative chemotaxis
JS559_00350	COG0601	transmembrane transport
JS559_00355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS559_00360	COG0444	Belongs to the ABC transporter superfamily
JS559_00365	COG4608	Belongs to the ABC transporter superfamily
JS559_00380	COG0251	oxidation-reduction process
JS559_00385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JS559_00390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JS559_00395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JS559_00400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JS559_00405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JS559_00410	COG0848	biopolymer transport protein
JS559_00415	COG0811	peptide transport
JS559_00420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JS559_00425	COG3118	belongs to the thioredoxin family
JS559_00430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS559_00430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS559_00430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JS559_00435	COG1461	Dihydroxyacetone kinase
JS559_00440	COG2376	Dihydroxyacetone kinase
JS559_00445	COG0492	ferredoxin-NADP+ reductase activity
JS559_00455	COG3753	Protein conserved in bacteria
JS559_00475	COG3030	protein affecting phage T7 exclusion by the F plasmid
JS559_00480	COG0006	proline dipeptidase activity
JS559_00490	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
JS559_00510	COG0129	dihydroxy-acid dehydratase activity
JS559_00515	COG3978	acetolactate synthase activity
JS559_00530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JS559_00535	COG0437	4 iron, 4 sulfur cluster binding
JS559_00540	COG3301	Polysulphide reductase, NrfD
JS559_00550	COG5295	Hep Hag repeat protein
JS559_00550	COG5295	Hep Hag repeat protein
JS559_00550	COG5295	Hep Hag repeat protein
JS559_00550	COG5295	Hep Hag repeat protein
JS559_00565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JS559_00570	COG1414	Transcriptional regulator
JS559_00575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JS559_00585	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JS559_00595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JS559_00600	COG3068	Protein conserved in bacteria
JS559_00620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JS559_00625	COG1278	Cold shock
JS559_00630	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JS559_00635	COG0793	Belongs to the peptidase S41A family
JS559_00640	COG2989	Protein conserved in bacteria
JS559_00645	COG3108	Peptidase M15
JS559_00650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JS559_00665	COG0537	adenosine 5'-monophosphoramidase activity
JS559_00670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JS559_00675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JS559_00685	COG1162	GTPase activity
JS559_00690	COG0583	DNA-binding transcription factor activity
JS559_00695	COG1011	Hydrolase
JS559_00700	COG0583	DNA-binding transcription factor activity
JS559_00710	COG0252	asparaginase activity
JS559_00715	COG0504	CTP synthase activity
JS559_00720	COG5413	integral membrane protein
JS559_00725	COG0066	3-isopropylmalate dehydratase activity
JS559_00730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JS559_00735	COG3835	regulator
JS559_00740	COG2610	gluconate transmembrane transporter activity
JS559_00745	COG1929	Belongs to the glycerate kinase type-1 family
JS559_00750	COG1254	Belongs to the acylphosphatase family
JS559_00755	COG3593	DNA synthesis involved in DNA repair
JS559_00760	COG1611	Belongs to the LOG family
JS559_00765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JS559_00775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JS559_00785	COG0316	Belongs to the HesB IscA family
JS559_00785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JS559_00790	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JS559_00795	COG1805	sodium ion transport
JS559_00800	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JS559_00805	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JS559_00810	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JS559_00815	COG2871	sodium ion transport
JS559_00820	COG1477	protein flavinylation
JS559_00825	COG2991	Protein conserved in bacteria
JS559_00830	COG0482	sulfurtransferase activity
JS559_00835	COG2814	Major facilitator Superfamily
JS559_00840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JS559_00850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JS559_00870	COG4657	Part of a membrane complex involved in electron transport
JS559_00875	COG2878	Part of a membrane complex involved in electron transport
JS559_00880	COG4656	Part of a membrane complex involved in electron transport
JS559_00890	COG4658	electron transport chain
JS559_00905	COG1560	Kdo2-lipid A biosynthetic process
JS559_00910	COG0402	S-adenosylhomocysteine deaminase activity
JS559_00915	COG4143	(ABC) transporter
JS559_00920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JS559_00925	COG0617	tRNA 3'-terminal CCA addition
JS559_00930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JS559_00940	COG2911	Protein conserved in bacteria
JS559_00950	COG0346	lactoylglutathione lyase activity
JS559_00955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JS559_00965	COG1605	Chorismate mutase
JS559_00965	COG0287	Prephenate dehydrogenase
JS559_00970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JS559_00975	COG0859	PFAM glycosyl transferase family 9
JS559_00980	COG0469	pyruvate kinase activity
JS559_00985	COG2062	phosphohistidine phosphatase, SixA
JS559_00990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JS559_00995	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JS559_01000	COG0733	neurotransmitter:sodium symporter activity
JS559_01005	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JS559_01010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JS559_01015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JS559_01020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JS559_01025	COG4972	Pilus assembly protein
JS559_01045	COG4796	Type ii and iii secretion system protein
JS559_01050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JS559_01055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JS559_01060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JS559_01065	COG1280	lysine exporter protein (LysE YggA)
JS559_01070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JS559_01095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JS559_01150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JS559_01155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JS559_01160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JS559_01175	COG1253	flavin adenine dinucleotide binding
JS559_01180	COG0564	pseudouridine synthase activity
JS559_01185	COG0588	phosphoglycerate mutase activity
JS559_01190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JS559_01195	COG1678	Uncharacterized ACR, COG1678
JS559_01200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JS559_01210	COG0271	Belongs to the BolA IbaG family
JS559_01235	COG0653	protein targeting
JS559_01245	COG0494	nUDIX hydrolase
JS559_01250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JS559_01260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JS559_01270	COG1629	transport
JS559_01270	COG4771	TonB-dependent receptor
JS559_01275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JS559_01280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JS559_01285	COG0083	homoserine kinase activity
JS559_01290	COG0460	homoserine dehydrogenase
JS559_01290	COG0527	aspartate kinase activity
JS559_01295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JS559_01300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JS559_01305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JS559_01330	COG2195	Cleaves the N-terminal amino acid of tripeptides
JS559_01335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JS559_01340	COG0194	GDP metabolic process
JS559_01345	COG1538	Outer membrane efflux protein
JS559_01350	COG2914	Belongs to the UPF0125 (RnfH) family
JS559_01355	COG2867	negative regulation of translational initiation
JS559_01360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JS559_01365	COG4149	molybdate abc transporter
JS559_01370	COG0725	ABC transporter, periplasmic molybdate-binding protein
JS559_01375	COG0842	Transport permease protein
JS559_01380	COG1131	(ABC) transporter
JS559_01385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JS559_01390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JS559_01400	COG0251	oxidation-reduction process
JS559_01410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JS559_01415	COG1121	(ABC) transporter
JS559_01425	COG2920	part of a sulfur-relay system
JS559_01430	COG0670	Belongs to the BI1 family
JS559_01435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JS559_01450	COG0084	hydrolase, TatD family'
JS559_01455	COG0210	DNA helicase
JS559_01460	COG3842	ATPase activity
JS559_01465	COG1176	ABC-type spermidine putrescine transport system, permease component I
JS559_01470	COG1177	transmembrane transport
JS559_01475	COG0632	four-way junction helicase activity
JS559_01480	COG2255	four-way junction helicase activity
JS559_01485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JS559_01490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JS559_01520	COG0488	(ABC) transporter
JS559_01525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JS559_01540	COG1271	oxidase subunit
JS559_01545	COG1294	oxidase, subunit
JS559_01560	COG0824	Thioesterase
JS559_01565	COG0811	peptide transport
JS559_01570	COG0848	biopolymer transport protein
JS559_01575	COG3064	Membrane
JS559_01575	COG3064	Membrane
JS559_01580	COG0823	Involved in the tonB-independent uptake of proteins
JS559_01595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JS559_01600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JS559_01610	COG0488	(ABC) transporter
JS559_01620	COG0303	'Molybdopterin
JS559_01625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JS559_01635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JS559_01640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JS559_01650	COG0564	pseudouridine synthase activity
JS559_01655	COG3023	N-Acetylmuramoyl-L-alanine amidase
JS559_01660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JS559_01665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JS559_01670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JS559_01675	COG2801	Transposase and inactivated derivatives
JS559_01695	COG2027	D-alanyl-D-alanine carboxypeptidase
JS559_01700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JS559_01710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JS559_01715	COG0156	8-amino-7-oxononanoate synthase activity
JS559_01720	COG2830	Protein of unknown function (DUF452)
JS559_01725	COG2226	methyltransferase
JS559_01730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JS559_01735	COG2840	Smr protein MutS2
JS559_01740	COG0697	spore germination
JS559_01745	COG0784	Response regulator, receiver
JS559_01745	COG5002	protein histidine kinase activity
JS559_01745	COG2198	Histidine kinase
JS559_01750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JS559_01760	COG1959	2 iron, 2 sulfur cluster binding
JS559_01765	COG1104	cysteine desulfurase activity
JS559_01770	COG0822	iron-sulfur transferase activity
JS559_01780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JS559_01795	COG0443	Heat shock 70 kDa protein
JS559_01800	COG0633	Ferredoxin
JS559_01805	COG2975	iron-sulfur cluster assembly
JS559_01835	COG0617	tRNA 3'-terminal CCA addition
JS559_01840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JS559_01850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JS559_01870	COG0583	DNA-binding transcription factor activity
JS559_01880	COG0110	maltose O-acetyltransferase activity
JS559_01890	COG3642	lipopolysaccharide core region biosynthetic process
JS559_01895	COG0302	gtp cyclohydrolase
JS559_01905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JS559_01910	COG1560	Kdo2-lipid A biosynthetic process
JS559_01915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JS559_01940	COG3058	Necessary for formate dehydrogenase activity
JS559_01945	COG2864	formate dehydrogenase
JS559_01950	COG0437	4 iron, 4 sulfur cluster binding
JS559_01960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JS559_01975	COG1250	3-hydroxyacyl-CoA dehydrogenase
JS559_01975	COG1024	Enoyl-CoA hydratase
JS559_01980	COG0183	Belongs to the thiolase family
JS559_01985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JS559_01990	COG0730	response to heat
JS559_01995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JS559_02000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JS559_02010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JS559_02015	COG4969	Belongs to the N-Me-Phe pilin family
JS559_02020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JS559_02025	COG1459	type II secretion system
JS559_02035	COG0237	dephospho-CoA kinase activity
JS559_02040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JS559_02045	COG1466	dna polymerase III delta subunit
JS559_02050	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JS559_02055	COG0495	leucyl-tRNA aminoacylation
JS559_02060	COG3340	Belongs to the peptidase S51 family
JS559_02065	COG3069	C4-dicarboxylate transmembrane transporter activity
JS559_02070	COG1473	amidohydrolase
JS559_02080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JS559_02085	COG3106	COG3106 Predicted ATPase
JS559_02090	COG3025	triphosphatase activity
JS559_02100	COG3140	Belongs to the UPF0181 family
JS559_02105	COG0564	pseudouridine synthase activity
JS559_02110	COG3098	single-species biofilm formation
JS559_02115	COG3177	Filamentation induced by cAMP protein fic
JS559_02120	COG0134	indole-3-glycerol-phosphate synthase activity
JS559_02120	COG0135	phosphoribosylanthranilate isomerase activity
JS559_02125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JS559_02125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JS559_02130	COG1760	l-serine dehydratase
JS559_02135	COG0814	amino acid
JS559_02140	COG0747	negative chemotaxis
JS559_02150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JS559_02160	COG4608	Belongs to the ABC transporter superfamily
JS559_02165	COG0444	Belongs to the ABC transporter superfamily
JS559_02175	COG4166	transmembrane transport
JS559_02180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JS559_02185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JS559_02190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JS559_02200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JS559_02205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JS559_02210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JS559_02220	COG0842	Transport permease protein
JS559_02225	COG0842	Transport permease protein
JS559_02225	COG1129	ABC transporter
JS559_02230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JS559_02235	COG1309	transcriptional regulator
JS559_02240	COG0717	Belongs to the dCTP deaminase family
JS559_02245	COG0572	uridine kinase
JS559_02255	COG0588	phosphoglycerate mutase activity
JS559_02260	COG4942	peptidase
JS559_02265	COG2861	carbohydrate metabolic process
JS559_02270	COG0729	surface antigen
JS559_02275	COG2911	Protein conserved in bacteria
JS559_02280	COG4988	ABC transporter
JS559_02285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JS559_02295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JS559_02300	COG1349	DNA-binding transcription factor activity
JS559_02305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JS559_02310	COG0187	DNA topoisomerase II activity
JS559_02315	COG0586	Pfam SNARE associated Golgi protein
JS559_02320	COG1609	Transcriptional regulator
JS559_02325	COG2351	hydroxyisourate hydrolase activity
JS559_02345	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JS559_02355	COG0500	methyltransferase
JS559_02370	COG1944	ATP diphosphatase activity
JS559_02375	COG1530	ribonuclease E activity
JS559_02380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JS559_02390	COG0142	geranyltranstransferase activity
JS559_02395	COG1722	exodeoxyribonuclease VII activity
JS559_02400	COG3217	Mosc domain protein beta barrel domain protein
JS559_02400	COG0633	Ferredoxin
JS559_02405	COG1368	sulfuric ester hydrolase activity
JS559_02415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JS559_02425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JS559_02430	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JS559_02440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JS559_02445	COG3283	Transcriptional regulator of aromatic amino acids metabolism
JS559_02450	COG4166	transmembrane transport
JS559_02455	COG4168	peptide transport system, permease
JS559_02460	COG4171	peptide transport system, permease
JS559_02465	COG4172	Belongs to the ABC transporter superfamily
JS559_02470	COG2315	Protein conserved in bacteria
JS559_02480	COG2070	2-Nitropropane dioxygenase
JS559_02515	COG0629	single-stranded DNA binding
JS559_02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JS559_02530	COG1199	ATP-dependent helicase activity
JS559_02540	COG1346	cytolysis
JS559_02545	COG1132	(ABC) transporter
JS559_02560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JS559_02570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JS559_02575	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS559_02580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JS559_02605	COG0737	Belongs to the 5'-nucleotidase family
JS559_02610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JS559_02615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JS559_02625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JS559_02640	COG2226	methyltransferase
JS559_02645	COG3036	rescue of stalled ribosome
JS559_02655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JS559_02660	COG1346	cytolysis
JS559_02665	COG1380	Effector of murein hydrolase LrgA
JS559_02685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JS559_02695	COG0596	Alpha beta hydrolase
JS559_02700	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JS559_02705	COG0318	PFAM AMP-dependent synthetase and ligase
JS559_02710	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JS559_02710	COG3264	Mechanosensitive ion channel
JS559_02715	COG3264	Mechanosensitive ion channel
JS559_02715	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JS559_02725	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
JS559_02730	COG1785	Belongs to the alkaline phosphatase family
JS559_02740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JS559_02750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JS559_02760	COG0539	negative regulation of cytoplasmic translation
JS559_02765	COG0776	regulation of translation
JS559_02770	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JS559_02775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JS559_02780	COG0284	orotidine-5'-phosphate decarboxylase activity
JS559_02785	COG0023	Translation Initiation Factor
JS559_02790	COG3787	Belongs to the UPF0306 family
JS559_02795	COG1811	Na channel or pump
JS559_02805	COG3094	Invasion gene expression up-regulator, SirB
JS559_02810	COG3028	Belongs to the UPF0307 family
JS559_02815	COG0312	modulator of DNA gyrase
JS559_02820	COG0440	acetolactate synthase activity
JS559_02825	COG0028	Belongs to the TPP enzyme family
JS559_02830	COG0288	reversible hydration of carbon dioxide
JS559_02835	COG1278	Cold shock
JS559_02850	COG2932	Transcriptional regulator
JS559_02855	COG3423	Transcriptional regulator
JS559_02865	COG2842	Transposition protein
JS559_02925	COG3561	AntA/AntB antirepressor
JS559_02945	COG3023	N-Acetylmuramoyl-L-alanine amidase
JS559_02990	COG4383	Mu-like prophage protein gp29
JS559_02995	COG2369	cell adhesion
JS559_03000	COG5005	Phage virion morphogenesis
JS559_03005	COG4388	Caudovirus prohead serine protease
JS559_03010	COG4397	Mu-like prophage major head subunit gpT
JS559_03110	COG0433	COG0433 Predicted ATPase
JS559_03115	COG1840	ABC-type Fe3 transport system, periplasmic component
JS559_03140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JS559_03145	COG2194	sulfuric ester hydrolase activity
JS559_03150	COG0528	UMP kinase activity
JS559_03155	COG0233	cytoplasmic translational termination
JS559_03160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS559_03175	COG0590	tRNA wobble adenosine to inosine editing
JS559_03180	COG0513	Belongs to the DEAD box helicase family
JS559_03185	COG4785	May be involved in cell division
JS559_03190	COG1185	polyribonucleotide nucleotidyltransferase activity
JS559_03195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JS559_03205	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JS559_03220	COG3083	sulfuric ester hydrolase activity
JS559_03225	COG3082	Protein of unknown function (DUF1414)
JS559_03230	COG1309	transcriptional regulator
JS559_03235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JS559_03240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JS559_03245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JS559_03255	COG3955	Domain of unknown function (DUF1919)
JS559_03260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS559_03275	COG0516	GMP reductase activity
JS559_03275	COG0517	IMP dehydrogenase activity
JS559_03280	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JS559_03285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JS559_03290	COG0814	amino acid
JS559_03295	COG0814	amino acid
JS559_03305	COG3105	Protein conserved in bacteria
JS559_03310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JS559_03320	COG3022	response to hydroperoxide
JS559_03335	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JS559_03340	COG1823	symporter activity
JS559_03345	COG0778	Nitroreductase
JS559_03350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JS559_03355	COG0072	phenylalanine-tRNA ligase activity
JS559_03360	COG0776	regulation of translation
JS559_03365	COG0791	NLP P60 protein
JS559_03375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JS559_03380	COG1846	Transcriptional regulator
JS559_03380	COG1940	carbohydrate kinase activity
JS559_03385	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JS559_03390	COG1522	sequence-specific DNA binding
JS559_03395	COG1674	ftsk spoiiie
JS559_03400	COG2321	neutral zinc metallopeptidase
JS559_03405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JS559_03410	COG1214	PFAM Peptidase M22, glycoprotease
JS559_03415	COG1435	thymidine kinase activity
JS559_03420	COG3074	FtsZ-dependent cytokinesis
JS559_03425	COG1494	fructose-1,6-bisphosphatase
JS559_03430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JS559_03435	COG1136	(ABC) transporter
JS559_03435	COG0577	efflux transmembrane transporter activity
JS559_03440	COG2205	protein histidine kinase activity
JS559_03445	COG0745	RESPONSE REGULATOR receiver
JS559_03450	COG3956	TIGRFAM MazG family protein
JS559_03460	COG0285	dihydrofolate synthase activity
JS559_03470	COG0779	Required for maturation of 30S ribosomal subunits
JS559_03475	COG0195	Participates in both transcription termination and antitermination
JS559_03480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JS559_03485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JS559_03490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JS559_03495	COG2951	lytic endotransglycosylase activity
JS559_03505	COG0280	phosphate acetyltransferase
JS559_03505	COG0857	belongs to the CobB CobQ family
JS559_03515	COG0737	Belongs to the 5'-nucleotidase family
JS559_03535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JS559_03545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JS559_03555	COG0589	response to stress
JS559_03565	COG2969	positive regulation of protein catabolic process
JS559_03570	COG0625	glutathione transferase activity
JS559_03575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JS559_03585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JS559_03590	COG1448	Aminotransferase
JS559_03595	COG2801	Transposase and inactivated derivatives
JS559_03600	COG0006	proline dipeptidase activity
JS559_03620	COG0556	nucleotide-excision repair
JS559_03625	COG2822	iron ion transport
JS559_03630	COG2837	iron assimilation
JS559_03640	COG0613	PHP domain protein
JS559_03650	COG2925	Exonuclease
JS559_03655	COG0038	chloride channel
JS559_03660	COG0017	Asparaginyl-tRNA synthetase
JS559_03665	COG1509	lysine 2,3-aminomutase activity
JS559_03675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JS559_03680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JS559_03685	COG2814	Major facilitator Superfamily
JS559_03690	COG0741	lytic transglycosylase activity
JS559_03695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JS559_03700	COG0626	cystathionine gamma-synthase activity
JS559_03705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JS559_03710	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JS559_03715	COG2363	Small membrane protein
JS559_03720	COG0277	FAD linked oxidase domain protein
JS559_03725	COG0243	molybdopterin cofactor binding
JS559_03730	COG3005	denitrification pathway
JS559_03735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JS559_03740	COG0315	cyclic pyranopterin monophosphate synthase activity
JS559_03745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JS559_03750	COG0314	molybdopterin synthase activity
JS559_03755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JS559_03760	COG1444	tRNA N-acetyltransferase activity
JS559_03770	COG0583	DNA-binding transcription factor activity
JS559_03775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JS559_03775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JS559_03780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JS559_03795	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JS559_03800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS559_03815	COG1737	Transcriptional regulator
JS559_03820	COG2731	YhcH YjgK YiaL family protein
JS559_03825	COG0248	Ppx GppA phosphatase
JS559_03830	COG2926	Belongs to the UPF0265 family
JS559_03835	COG0527	aspartate kinase activity
JS559_03840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JS559_03845	COG3100	YcgL domain-containing protein
JS559_03850	COG0305	Participates in initiation and elongation during chromosome replication
JS559_03855	COG4607	ABC-type enterochelin transport system periplasmic component
JS559_03860	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JS559_03865	COG4605	iron ion homeostasis
JS559_03870	COG4604	ABC transporter, ATP-binding protein
JS559_03875	COG1392	Phosphate transport regulator
JS559_03880	COG0306	phosphate transporter
JS559_03885	COG4991	sh3 domain protein
JS559_03895	COG3945	hemerythrin HHE cation binding domain
JS559_03985	COG4397	Mu-like prophage major head subunit gpT
JS559_03990	COG4388	Caudovirus prohead serine protease
JS559_03995	COG5005	Phage virion morphogenesis
JS559_04000	COG2369	cell adhesion
JS559_04005	COG4383	Mu-like prophage protein gp29
JS559_04050	COG3023	N-Acetylmuramoyl-L-alanine amidase
JS559_04070	COG3561	AntA/AntB antirepressor
JS559_04130	COG2842	Transposition protein
JS559_04140	COG3423	Transcriptional regulator
JS559_04145	COG2932	Transcriptional regulator
JS559_04220	COG1381	Involved in DNA repair and RecF pathway recombination
JS559_04225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JS559_04230	COG0571	ribonuclease III activity
JS559_04235	COG0681	Belongs to the peptidase S26 family
JS559_04240	COG0481	GTPase activity
JS559_04250	COG0351	phosphomethylpyrimidine kinase
JS559_04255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JS559_04260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JS559_04265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JS559_04270	COG2022	thiamine diphosphate biosynthetic process
JS559_04280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JS559_04285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JS559_04290	COG1116	anion transmembrane transporter activity
JS559_04295	COG1116	anion transmembrane transporter activity
JS559_04300	COG1115	amino acid carrier protein
JS559_04305	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
JS559_04310	COG3683	transport system, periplasmic component
JS559_04435	COG1802	Transcriptional regulator
JS559_04435	COG4626	Terminase
JS559_04480	COG1403	HNH endonuclease
JS559_04505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JS559_04590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JS559_04595	COG0281	malic enzyme
JS559_04595	COG0280	phosphate acetyltransferase
JS559_04600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JS559_04605	COG0189	ligase activity
JS559_04615	COG0640	Transcriptional regulator
JS559_04640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JS559_04645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JS559_04655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JS559_04670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JS559_04670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JS559_04695	COG4221	oxidoreductase activity
JS559_04705	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JS559_04710	COG0393	Putative heavy-metal-binding
JS559_04715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JS559_04725	COG3850	Histidine kinase
JS559_04730	COG0561	phosphatase activity
JS559_04740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JS559_04745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JS559_04750	COG0739	heme binding
JS559_04755	COG1121	(ABC) transporter
JS559_04760	COG0567	Dehydrogenase, E1 component
JS559_04765	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS559_04770	COG2990	Protein conserved in bacteria
JS559_04775	COG0045	succinate-CoA ligase (ADP-forming) activity
JS559_04780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JS559_04785	COG1879	ABC-type sugar transport system periplasmic component
JS559_04790	COG1757	Na H antiporter
JS559_04795	COG2916	Histone family protein nucleoid-structuring protein H-NS
JS559_04800	COG1620	l-lactate permease
JS559_04805	COG0247	lactate metabolic process
JS559_04810	COG1139	Iron-sulfur cluster binding protein
JS559_04815	COG1556	Lactate utilization protein
JS559_04825	COG2801	Transposase and inactivated derivatives
JS559_04835	COG2949	membrane
JS559_04840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JS559_04845	COG0121	glutamine amidotransferase
JS559_04850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JS559_04855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JS559_04860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JS559_04865	COG1792	Involved in formation and maintenance of cell shape
JS559_04875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JS559_04890	COG5645	(Lipo)protein
JS559_04940	COG0582	viral genome integration into host DNA
JS559_04950	COG1496	oxidoreductase activity
JS559_04955	COG0251	oxidation-reduction process
JS559_04960	COG3081	Nucleoid-associated protein
JS559_04965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JS559_04970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JS559_04980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JS559_04985	COG1286	toxin biosynthetic process
JS559_04990	COG0328	RNA-DNA hybrid ribonuclease activity
JS559_05000	COG0859	PFAM glycosyl transferase family 9
JS559_05005	COG1686	Belongs to the peptidase S11 family
JS559_05010	COG0463	Glycosyl transferase, family 2
JS559_05015	COG1534	Rna-binding protein
JS559_05020	COG0671	phosphoesterase, PA-phosphatase related
JS559_05030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JS559_05035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JS559_05040	COG0575	Belongs to the CDS family
JS559_05045	COG0750	zinc metalloprotease
JS559_05060	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JS559_05065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JS559_05070	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JS559_05080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JS559_05090	COG1160	GTP binding
JS559_05095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JS559_05095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JS559_05100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JS559_05105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JS559_05115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JS559_05120	COG0318	PFAM AMP-dependent synthetase and ligase
JS559_05130	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JS559_05135	COG1595	DNA-templated transcription, initiation
JS559_05145	COG0561	phosphatase activity
JS559_05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JS559_05155	COG0385	Bile acid
JS559_05160	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JS559_05170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JS559_05170	COG0517	IMP dehydrogenase activity
JS559_05200	COG0247	lactate metabolic process
JS559_05205	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
JS559_05210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JS559_05215	COG0584	glycerophosphoryl diester phosphodiesterase
JS559_05220	COG2271	Major facilitator Superfamily
JS559_05225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JS559_05230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JS559_05235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JS559_05245	COG4535	Mg2 and Co2 transporter CorC
JS559_05250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JS559_05255	COG1074	ATP-dependent DNA helicase activity
JS559_05260	COG0534	Mate efflux family protein
JS559_05265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JS559_05270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JS559_05275	COG2707	UPF0756 membrane protein
JS559_05280	COG1643	Atp-dependent helicase
JS559_05290	COG2990	Protein conserved in bacteria
JS559_05295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JS559_05300	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JS559_05305	COG2932	Transcriptional regulator
JS559_05310	COG0791	NLP P60 protein
JS559_05320	COG3381	protein complex oligomerization
JS559_05335	COG1187	pseudouridine synthase activity
JS559_05350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JS559_05350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JS559_05355	COG0105	UTP biosynthetic process
JS559_05360	COG0058	SHG alpha-glucan phosphorylase activity
JS559_05365	COG0297	glycogen (starch) synthase activity
JS559_05370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JS559_05375	COG1523	belongs to the glycosyl hydrolase 13 family
JS559_05380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JS559_05385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS559_05385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS559_05390	COG1105	Belongs to the carbohydrate kinase PfkB family
JS559_05395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JS559_05395	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JS559_05395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JS559_05400	COG1704	LemA family
JS559_05410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JS559_05415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JS559_05425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JS559_05430	COG1137	ATPase activity
JS559_05435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS559_05445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JS559_05465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JS559_05490	COG1702	phosphate starvation-inducible protein PhoH
JS559_05505	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JS559_05510	COG0626	cystathionine gamma-synthase activity
JS559_05515	COG2801	Transposase and inactivated derivatives
JS559_05525	COG2856	Zn peptidase
JS559_05530	COG3620	sequence-specific DNA binding
JS559_05565	COG1444	tRNA N-acetyltransferase activity
JS559_05570	COG0138	bifunctional purine biosynthesis protein purh
JS559_05595	COG3210	domain, Protein
JS559_05600	COG2831	hemolysin activation secretion protein
JS559_05605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JS559_05610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JS559_05620	COG3078	GTPase activator activity
JS559_05625	COG2985	domain, Protein
JS559_05625	COG0569	domain protein
JS559_05630	COG0786	glutamate:sodium symporter activity
JS559_05640	COG3112	Uncharacterised protein family (UPF0231)
JS559_05650	COG2350	Protein conserved in bacteria
JS559_05655	COG1607	acyl-coa hydrolase
JS559_05670	COG3092	negative regulation of chromosome organization
JS559_05675	COG0037	tRNA processing
JS559_05680	COG2056	Na+-H+ antiporter family
JS559_05685	COG0708	Exodeoxyribonuclease III
JS559_05690	COG0583	DNA-binding transcription factor activity
JS559_05710	COG0254	rRNA binding
JS559_05725	COG0753	catalase activity
JS559_05735	COG1408	metallophosphoesterase
JS559_05740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JS559_05745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JS559_05750	COG1085	galactose-1-phosphate uridylyltransferase
JS559_05760	COG2017	converts alpha-aldose to the beta-anomer
JS559_05780	COG0489	protein tyrosine kinase activity
JS559_05785	COG4166	transmembrane transport
JS559_05790	COG2095	MarC family integral membrane protein
JS559_05795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JS559_05805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JS559_05810	COG2354	Protein conserved in bacteria
JS559_05815	COG3071	HemY protein
JS559_05820	COG2959	enzyme of heme biosynthesis
JS559_05830	COG0181	hydroxymethylbilane synthase activity
JS559_05835	COG1454	alcohol dehydrogenase
JS559_05835	COG1012	belongs to the aldehyde dehydrogenase family
JS559_05840	COG0459	protein refolding
JS559_05850	COG0813	purine-nucleoside phosphorylase activity
JS559_05855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JS559_05860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JS559_05865	COG2364	Membrane
JS559_05870	COG0800	Aldolase
JS559_05875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS559_05880	COG1904	glucuronate isomerase
JS559_05890	COG2186	Transcriptional regulator
JS559_05900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JS559_05900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JS559_05905	COG1216	Glycosyl transferase, family 2
JS559_05910	COG1216	Glycosyl transferase, family 2
JS559_05920	COG3306	glycosyltransferase involved in LPS biosynthesis
JS559_05930	COG5039	Polysaccharide pyruvyl transferase
JS559_05935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JS559_05940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JS559_05945	COG1605	Chorismate mutase
JS559_05945	COG0077	Prephenate dehydratase
JS559_05950	COG0339	signal peptide processing
JS559_05955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JS559_05960	COG1882	Formate acetyltransferase
JS559_05965	COG2116	formate transmembrane transporter activity
JS559_05970	COG1238	metal cluster binding
JS559_05975	COG0501	Belongs to the peptidase M48B family
JS559_05980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JS559_05985	COG2431	L-lysine efflux transmembrane transporter activity
JS559_05990	COG1169	isochorismate synthase
JS559_05995	COG0436	Aminotransferase
JS559_06000	COG2962	Rard protein
JS559_06005	COG2962	Rard protein
JS559_06015	COG4771	TonB-dependent receptor
JS559_06015	COG1629	transport
JS559_06020	COG0748	coenzyme F420 binding
JS559_06030	COG3088	subunit of a heme lyase
JS559_06030	COG4235	cytochrome complex assembly
JS559_06035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JS559_06040	COG1138	Cytochrome C-type biogenesis protein
JS559_06045	COG0475	glutathione-regulated potassium exporter activity
JS559_06045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JS559_06055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JS559_06065	COG3111	PFAM Bacterial OB fold (BOF) protein
JS559_06080	COG0745	RESPONSE REGULATOR receiver
JS559_06085	COG0642	Histidine kinase
JS559_06090	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JS559_06095	COG1862	Preprotein translocase
JS559_06100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JS559_06105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JS559_06110	COG1528	Iron-storage protein
JS559_06115	COG1528	Iron-storage protein
JS559_06120	COG2252	PERMEase
JS559_06125	COG0424	maF-like protein
JS559_06135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JS559_06135	COG0301	tRNA thio-modification
JS559_06140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JS559_06145	COG0330	HflC and HflK could
JS559_06150	COG0330	HflC and HflK could
JS559_06155	COG3118	belongs to the thioredoxin family
JS559_06165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JS559_06175	COG0531	amino acid
JS559_06180	COG0531	amino acid
JS559_06195	COG3047	cAMP biosynthetic process
JS559_06200	COG0542	response to heat
JS559_06205	COG0798	PFAM Bile acid sodium symporter
JS559_06220	COG1027	Aspartate ammonia-lyase
JS559_06230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JS559_06235	COG3583	domain protein
JS559_06235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JS559_06235	COG3064	Membrane
JS559_06245	COG0720	synthase
JS559_06250	COG0602	queuosine metabolic process
JS559_06265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JS559_06275	COG0795	lipopolysaccharide-transporting ATPase activity
JS559_06280	COG0795	lipopolysaccharide-transporting ATPase activity
JS559_06290	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JS559_06295	COG2937	Belongs to the GPAT DAPAT family
JS559_06300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JS559_06305	COG3066	DNA modification
JS559_06310	COG0861	Integral membrane protein TerC family
JS559_06315	COG1472	Belongs to the glycosyl hydrolase 3 family
JS559_06325	COG0148	phosphopyruvate hydratase activity
JS559_06330	COG1051	belongs to the nudix hydrolase family
JS559_06335	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
JS559_06345	COG1965	Belongs to the frataxin family
JS559_06355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JS559_06360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JS559_06365	COG0564	pseudouridine synthase activity
JS559_06375	COG0205	6-phosphofructokinase activity
JS559_06380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JS559_06385	COG1525	nuclease
JS559_06390	COG1115	amino acid carrier protein
JS559_06395	COG0628	permease
JS559_06405	COG0826	peptidase U32
JS559_06410	COG3307	-O-antigen
JS559_06415	COG1519	Transferase
JS559_06425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JS559_06430	COG0802	atpase or kinase
JS559_06435	COG1388	LysM domain
JS559_06435	COG0860	N-Acetylmuramoyl-L-alanine amidase
JS559_06440	COG0166	Belongs to the GPI family
JS559_06445	COG2960	long-chain fatty acid transporting porin activity
JS559_06475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JS559_06485	COG0551	DNA topoisomerase type I activity
JS559_06495	COG2137	regulation of response to DNA damage stimulus
JS559_06500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JS559_06505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JS559_06515	COG1322	Protein conserved in bacteria
JS559_06520	COG0512	Glutamine amidotransferase of anthranilate synthase
JS559_06535	COG0494	nUDIX hydrolase
JS559_06540	COG0217	transcriptional regulatory protein
JS559_06550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JS559_06555	COG0612	Peptidase, M16
JS559_06570	COG0583	DNA-binding transcription factor activity
JS559_06575	COG3266	domain, Protein
JS559_06585	COG1187	pseudouridine synthase activity
JS559_06590	COG0009	L-threonylcarbamoyladenylate synthase
JS559_06600	COG2837	iron assimilation
JS559_06605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JS559_06610	COG0512	Glutamine amidotransferase of anthranilate synthase
JS559_06620	COG2226	methyltransferase
JS559_06625	COG2268	Band 7 protein
JS559_06630	COG2841	Protein conserved in bacteria
JS559_06645	COG2965	DNA replication, synthesis of RNA primer
JS559_06660	COG3201	nicotinamide mononucleotide transporter
JS559_06665	COG2976	Protein conserved in bacteria
JS559_06675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JS559_06680	COG1426	Protein conserved in bacteria
JS559_06685	COG0659	secondary active sulfate transmembrane transporter activity
JS559_06695	COG0673	inositol 2-dehydrogenase activity
JS559_06700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JS559_06700	COG0475	glutathione-regulated potassium exporter activity
JS559_06705	COG1373	ATPase (AAA superfamily
JS559_06750	COG1902	pentaerythritol trinitrate reductase activity
JS559_06775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JS559_06780	COG2084	Dehydrogenase
JS559_06785	COG0778	Nitroreductase
JS559_06790	COG2095	MarC family integral membrane protein
JS559_06820	COG0625	glutathione transferase activity
JS559_06835	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JS559_06840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JS559_06855	COG1275	C4-dicarboxylate transporter malic acid transport protein
JS559_06860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JS559_06875	COG1132	(ABC) transporter
JS559_06880	COG1854	S-ribosylhomocysteine lyase activity
JS559_06885	COG3008	intermembrane lipid transfer
JS559_06890	COG0735	belongs to the Fur family
JS559_06895	COG0716	FMN binding
JS559_06905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JS559_06910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JS559_06915	COG2252	PERMEase
JS559_06920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JS559_06925	COG2081	HI0933 family
JS559_06930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JS559_06940	COG0560	Phosphoserine phosphatase
JS559_06955	COG0058	SHG alpha-glucan phosphorylase activity
JS559_06960	COG2909	trisaccharide binding
JS559_06970	COG4580	involved in the transport of maltose and maltodextrins
JS559_06975	COG3842	ATPase activity
JS559_06990	COG3833	ABC-type maltose transport systems, permease component
JS559_06995	COG1640	4-alpha-glucanotransferase
JS559_07000	COG1966	Carbon starvation protein
JS559_07005	COG0084	hydrolase, TatD family'
JS559_07010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JS559_07025	COG0778	Nitroreductase
JS559_07040	COG4172	Belongs to the ABC transporter superfamily
JS559_07045	COG0191	fructose-bisphosphate aldolase activity
JS559_07050	COG0126	phosphoglycerate kinase activity
JS559_07055	COG0471	metal ion transport
JS559_07060	COG0471	metal ion transport
JS559_07065	COG0471	metal ion transport
JS559_07070	COG0187	DNA topoisomerase II activity
JS559_07075	COG5002	protein histidine kinase activity
JS559_07080	COG0745	RESPONSE REGULATOR receiver
JS559_07105	COG0789	Transcriptional regulator
JS559_07125	COG0300	oxidoreductase activity
JS559_07130	COG0778	Nitroreductase
JS559_07135	COG0616	signal peptide processing
JS559_07140	COG3719	Belongs to the RNase T2 family
JS559_07150	COG1252	NADH dehydrogenase
JS559_07155	COG2183	response to ionizing radiation
JS559_07160	COG3063	Type IV pilus biogenesis stability protein PilW
JS559_07165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JS559_07200	COG2161	toxin-antitoxin pair type II binding
JS559_07205	COG4115	mRNA cleavage
JS559_07215	COG2835	tetraacyldisaccharide 4'-kinase activity
JS559_07220	COG1663	tetraacyldisaccharide 4'-kinase activity
JS559_07225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JS559_07235	COG2166	iron-sulfur cluster assembly
JS559_07255	COG0488	(ABC) transporter
JS559_07260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JS559_07275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JS559_07280	COG5007	Belongs to the BolA IbaG family
JS559_07290	COG2854	intermembrane phospholipid transfer
JS559_07295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JS559_07300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JS559_07305	COG1127	ABC transporter
JS559_07310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JS559_07315	COG1090	epimerase
JS559_07345	COG2814	Major facilitator Superfamily
JS559_07355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JS559_07360	COG3115	cell septum assembly
JS559_07375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JS559_07390	COG2814	Major facilitator Superfamily
JS559_07395	COG0363	glucosamine-6-phosphate deaminase activity
JS559_07400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JS559_07405	COG1218	3'(2'),5'-bisphosphate nucleotidase
JS559_07410	COG0494	nUDIX hydrolase
JS559_07415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JS559_07420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JS559_07425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JS559_07430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JS559_07435	COG0549	Belongs to the carbamate kinase family
JS559_07445	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JS559_07450	COG1178	ABC-type Fe3 transport system permease component
JS559_07455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS559_07460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS559_07465	COG2190	(PTS) system
JS559_07470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JS559_07475	COG0210	DNA helicase
JS559_07480	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JS559_07485	COG0409	Hydrogenase expression formation protein
JS559_07490	COG0309	Hydrogenase expression formation protein (HypE)
JS559_07495	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JS559_07500	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
JS559_07505	COG0437	4 iron, 4 sulfur cluster binding
JS559_07510	COG5557	Pfam Polysulphide reductase, NrfD
JS559_07515	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
JS559_07520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JS559_07525	COG1773	rubredoxin
JS559_07530	COG0298	carbon dioxide binding
JS559_07535	COG0375	protein maturation
JS559_07570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JS559_07575	COG0308	aminopeptidase N
JS559_07580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JS559_07585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JS559_07590	COG0295	cytidine deaminase activity
JS559_07595	COG2177	Part of the ABC transporter FtsEX involved in
JS559_07600	COG2884	Cell division ATP-binding protein ftsE
JS559_07605	COG0552	protein localization to endoplasmic reticulum
JS559_07610	COG0742	ribosomal rna small subunit methyltransferase
JS559_07615	COG3099	Belongs to the UPF0263 family
JS559_07620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JS559_07630	COG4160	amino acid transport
JS559_07635	COG4215	(ABC) transporter
JS559_07640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JS559_07645	COG1126	abc transporter atp-binding protein
JS559_07650	COG1881	PFAM PEBP family protein
JS559_07660	COG3620	sequence-specific DNA binding
JS559_07670	COG4232	protein-disulfide reductase activity
JS559_07675	COG3101	peptidyl-lysine hydroxylation
JS559_07685	COG3107	peptidoglycan biosynthetic process
JS559_07690	COG0792	nuclease activity
JS559_07695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JS559_07730	COG1138	Cytochrome C-type biogenesis protein
JS559_07735	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JS559_07740	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JS559_07745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JS559_07750	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JS559_07755	COG4133	protoheme IX ABC transporter activity
JS559_07760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JS559_07795	COG3630	sodium ion export across plasma membrane
JS559_07805	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JS559_07810	COG2824	Alkylphosphonate utilization operon protein PhnA
JS559_07815	COG1858	cytochrome C peroxidase
JS559_07820	COG1872	DUF167
JS559_07825	COG0762	integral membrane protein
JS559_07830	COG3171	Protein conserved in bacteria
JS559_07835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JS559_07840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JS559_07845	COG0416	fatty acid biosynthetic process
JS559_07850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JS559_07855	COG1399	metal-binding, possibly nucleic acid-binding protein
JS559_07865	COG4536	flavin adenine dinucleotide binding
JS559_07870	COG0733	neurotransmitter:sodium symporter activity
JS559_07880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JS559_07880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS559_07885	COG3715	PTS system
JS559_07890	COG3716	PTS system mannose fructose sorbose family IID component
JS559_07915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JS559_07915	COG0678	peroxiredoxin activity
JS559_07920	COG0583	DNA-binding transcription factor activity
JS559_07925	COG1309	transcriptional regulator
JS559_07930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JS559_07935	COG0557	exoribonuclease II activity
JS559_07945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JS559_07950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JS559_07960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JS559_07965	COG1088	dTDP-glucose 4,6-dehydratase activity
JS559_07970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JS559_07995	COG1442	glycosyl transferase family 8
JS559_07995	COG1216	Glycosyl transferase, family 2
JS559_08015	COG0316	Belongs to the HesB IscA family
JS559_08020	COG1575	Belongs to the MenA family. Type 1 subfamily
JS559_08025	COG4804	nuclease activity
JS559_08030	COG1720	tRNA m6t6A37 methyltransferase activity
JS559_08040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JS559_08060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS559_08065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JS559_08070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JS559_08080	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JS559_08090	COG1755	Isoprenylcysteine carboxyl methyltransferase
JS559_08100	COG1530	ribonuclease E activity
JS559_08115	COG2249	NAD(P)H dehydrogenase (quinone) activity
JS559_08120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JS559_08130	COG0243	molybdopterin cofactor binding
JS559_08135	COG0437	4 iron, 4 sulfur cluster binding
JS559_08140	COG0348	domain, Protein
JS559_08145	COG3043	anaerobic respiration
JS559_08150	COG3005	denitrification pathway
JS559_08160	COG2050	protein possibly involved in aromatic compounds catabolism
JS559_08165	COG0277	FAD linked oxidase domain protein
JS559_08165	COG0247	lactate metabolic process
JS559_08170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
JS559_08170	COG2885	chlorophyll binding
JS559_08175	COG1879	ABC-type sugar transport system periplasmic component
JS559_08180	COG1129	ABC transporter
JS559_08185	COG4211	Belongs to the binding-protein-dependent transport system permease family
JS559_08210	COG1022	Amp-dependent synthetase and ligase
JS559_08215	COG4989	oxidoreductase activity
JS559_08220	COG3691	Protein conserved in bacteria
JS559_08225	COG0814	amino acid
JS559_08235	COG2918	glutathione biosynthetic process
JS559_08235	COG1181	Belongs to the D-alanine--D-alanine ligase family
JS559_08240	COG0688	phosphatidylethanolamine metabolic process
JS559_08245	COG1555	photosystem II stabilization
JS559_08250	COG3266	domain, Protein
JS559_08250	COG3061	Opacity-associated protein A
JS559_08260	COG0859	PFAM glycosyl transferase family 9
JS559_08265	COG0859	PFAM glycosyl transferase family 9
JS559_08270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JS559_08275	COG0049	tRNA binding
JS559_08280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JS559_08285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JS559_08300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JS559_08315	COG1840	ABC-type Fe3 transport system, periplasmic component
JS559_08360	COG0825	malonyl-CoA metabolic process
JS559_08370	COG0204	Acyl-transferase
JS559_08375	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JS559_08385	COG2848	UPF0210 protein
JS559_08400	COG0783	Belongs to the Dps family
JS559_08415	COG1289	transmembrane transporter activity
JS559_08420	COG1803	Methylglyoxal synthase
JS559_08425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JS559_08435	COG0525	valine-tRNA ligase activity
JS559_08450	COG2153	protein acetylation
JS559_08455	COG2927	DNA polymerase III (CHI subunit)
JS559_08460	COG1652	LysM domain
JS559_08470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JS559_08475	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JS559_08480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JS559_08485	COG1045	serine acetyltransferase
JS559_08490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JS559_08520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JS559_08535	COG0521	Mo-molybdopterin cofactor biosynthetic process
JS559_08545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JS559_08555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JS559_08570	COG0625	glutathione transferase activity
JS559_08575	COG0019	diaminopimelate decarboxylase activity
JS559_08585	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JS559_08590	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JS559_08595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JS559_08600	COG1053	succinate dehydrogenase
JS559_08605	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JS559_08615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JS559_08620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JS559_08640	COG2264	protein methyltransferase activity
JS559_08660	COG0037	tRNA processing
JS559_08670	COG4974	Belongs to the 'phage' integrase family
JS559_08725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JS559_08740	COG1151	hydroxylamine reductase activity
JS559_08745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JS559_08750	COG2244	polysaccharide biosynthetic process
JS559_08755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JS559_08765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JS559_08770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JS559_08775	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
JS559_08785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JS559_08795	COG0728	peptidoglycan biosynthetic process
JS559_08800	COG0268	Binds directly to 16S ribosomal RNA
JS559_08805	COG0569	domain protein
JS559_08810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JS559_08815	COG3276	selenocysteine insertion sequence binding
JS559_08820	COG1921	L-seryl-tRNASec selenium transferase activity
JS559_08830	COG0716	FMN binding
JS559_08850	COG1629	transport
JS559_08850	COG4771	TonB-dependent receptor
JS559_08875	COG2431	L-lysine efflux transmembrane transporter activity
JS559_08890	COG3545	Serine hydrolase
JS559_08915	COG1216	Glycosyl transferase, family 2
JS559_08915	COG0463	Glycosyl transferase, family 2
JS559_08925	COG0463	Glycosyl transferase, family 2
JS559_08950	COG1119	ATPase activity
JS559_08965	COG1739	Uncharacterized protein family UPF0029
JS559_08970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JS559_08975	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
JS559_08980	COG1970	mechanosensitive ion channel activity
JS559_08985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JS559_08990	COG0321	lipoyl(octanoyl) transferase activity
JS559_08995	COG2921	Belongs to the UPF0250 family
JS559_09000	COG1686	Belongs to the peptidase S11 family
JS559_09005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS559_09010	COG0772	Belongs to the SEDS family
JS559_09015	COG0768	penicillin binding
JS559_09020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JS559_09025	COG0799	negative regulation of ribosome biogenesis
JS559_09035	COG1126	abc transporter atp-binding protein
JS559_09040	COG0765	amino acid transport
JS559_09045	COG3681	Belongs to the UPF0597 family
JS559_09050	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JS559_09060	COG3691	Protein conserved in bacteria
JS559_09075	COG0829	nickel cation binding
JS559_09080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JS559_09085	COG0830	nickel cation binding
JS559_09110	COG0831	urea catabolic process
JS559_09120	COG1122	ATPase activity
JS559_09125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JS559_09130	COG0310	cobalt ion transport
JS559_09135	COG0310	cobalt ion transport
JS559_09140	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
JS559_09145	COG0583	DNA-binding transcription factor activity
JS559_09155	COG0490	domain, Protein
JS559_09155	COG0471	metal ion transport
JS559_09160	COG3722	fumarate hydratase activity
JS559_09175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JS559_09180	COG1349	DNA-binding transcription factor activity
JS559_09195	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
JS559_09205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JS559_09210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JS559_09215	COG2900	Belongs to the SlyX family
JS559_09220	COG0545	Peptidyl-prolyl cis-trans isomerase
JS559_09225	COG2964	Protein conserved in bacteria
JS559_09230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JS559_09240	COG2168	tRNA wobble position uridine thiolation
JS559_09270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JS559_09275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JS559_09280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JS559_09285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JS559_09290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JS559_09310	COG0357	Ribosomal RNA small subunit methyltransferase G
JS559_09315	COG0445	tRNA wobble uridine modification
JS559_09320	COG0561	phosphatase activity
JS559_09325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JS559_09330	COG3012	SEC-C Motif Domain Protein
JS559_09340	COG3716	PTS system mannose fructose sorbose family IID component
JS559_09345	COG3715	PTS system
JS559_09350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS559_09350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JS559_09355	COG2610	gluconate transmembrane transporter activity
JS559_09360	COG3265	gluconokinase activity
JS559_09365	COG1609	Transcriptional regulator
JS559_09370	COG1609	Transcriptional regulator
JS559_09375	COG1869	D-ribose catabolic process
JS559_09385	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS559_09390	COG1879	ABC-type sugar transport system periplasmic component
JS559_09395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS559_09400	COG0243	molybdopterin cofactor binding
JS559_09405	COG0437	4 iron, 4 sulfur cluster binding
JS559_09410	COG3302	dmso reductase anchor subunit
JS559_09415	COG3381	protein complex oligomerization
JS559_09420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JS559_09420	COG2221	Nitrite and sulphite reductase 4Fe-4S
JS559_09455	COG0738	Major facilitator superfamily
JS559_09460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS559_09465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JS559_09470	COG1349	DNA-binding transcription factor activity
JS559_09475	COG1349	DNA-binding transcription factor activity
JS559_09480	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
JS559_09485	COG1070	Carbohydrate kinase
JS559_09490	COG4154	Belongs to the RbsD FucU family
JS559_09495	COG0235	Class ii aldolase
JS559_09500	COG0738	Major facilitator superfamily
JS559_09505	COG1454	alcohol dehydrogenase
JS559_09510	COG3477	response to acidic pH
JS559_09515	COG0765	amino acid transport
JS559_09525	COG1126	abc transporter atp-binding protein
JS559_09530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JS559_09550	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JS559_09575	COG3623	hexulose-6-phosphate isomerase
JS559_09580	COG0235	Class ii aldolase
JS559_09585	COG0545	Peptidyl-prolyl cis-trans isomerase
JS559_09605	COG4783	chaperone-mediated protein folding
JS559_09610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JS559_09620	COG0758	DNA mediated transformation
JS559_09625	COG1297	OPT oligopeptide transporter protein
JS559_09640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JS559_09650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JS559_09655	COG0081	regulation of translation
JS559_09660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JS559_09665	COG0222	ribosome binding
JS559_09710	COG0085	RNA polymerase activity
JS559_09720	COG0827	DNA restriction-modification system
JS559_09735	COG1487	ribonuclease activity
JS559_09755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JS559_09760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JS559_09765	COG1489	DNA binding
JS559_09770	COG0346	lactoylglutathione lyase activity
JS559_09775	COG1194	a g-specific adenine glycosylase
JS559_09780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JS559_09785	COG0741	lytic transglycosylase activity
JS559_09810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JS559_09815	COG0737	Belongs to the 5'-nucleotidase family
JS559_09820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JS559_09825	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JS559_09830	COG3657	addiction module killer protein
JS559_09835	COG0606	chelatase, subunit chli
JS559_09845	COG2267	carboxylic ester hydrolase activity
JS559_09850	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JS559_09860	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JS559_09870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JS559_09875	COG0363	glucosamine-6-phosphate deaminase activity
JS559_09880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JS559_09895	COG0051	transcription antitermination factor activity, RNA binding
JS559_09900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JS559_09905	COG0088	Forms part of the polypeptide exit tunnel
JS559_09910	COG0089	rRNA binding
JS559_09915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JS559_09920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JS559_09925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JS559_09930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JS559_09935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JS559_09940	COG0255	Belongs to the universal ribosomal protein uL29 family
JS559_09945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JS559_09955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JS559_09960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JS559_09965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JS559_09970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JS559_09975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JS559_09980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JS559_09985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JS559_09990	COG1841	ribosomal large subunit assembly
JS559_09995	COG0200	Binds to the 23S rRNA
JS559_10000	COG0201	protein transport
JS559_10010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JS559_10015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JS559_10020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JS559_10025	COG0202	RNA polymerase activity
JS559_10035	COG0228	four-way junction DNA binding
JS559_10040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JS559_10045	COG0336	Belongs to the RNA methyltransferase TrmD family
JS559_10050	COG0335	large ribosomal subunit rRNA binding
JS559_10055	COG2850	peptidyl-arginine hydroxylation
JS559_10060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JS559_10065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JS559_10105	COG0752	glycyl-tRNA synthetase alpha subunit
JS559_10110	COG2852	Protein conserved in bacteria
JS559_10120	COG0751	glycine-tRNA ligase activity
JS559_10135	COG2832	Protein of unknown function (DUF454)
JS559_10145	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JS559_10155	COG0084	hydrolase, TatD family'
JS559_10170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JS559_10180	COG0470	DNA polymerase III
JS559_10185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JS559_10190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JS559_10210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JS559_10215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JS559_10220	COG0254	rRNA binding
JS559_10225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JS559_10230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JS559_10235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JS559_10240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JS559_10250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JS559_10265	COG0442	prolyl-tRNA aminoacylation
JS559_10270	COG1595	DNA-templated transcription, initiation
JS559_10275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JS559_10285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JS559_10310	COG2502	aspartate--ammonia ligase
JS559_10315	COG1522	sequence-specific DNA binding
JS559_10320	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JS559_10330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JS559_10360	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JS559_10390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JS559_10400	COG4208	sulfate ABC transporter
JS559_10405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JS559_10410	COG1304	FMN binding
JS559_10420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JS559_10430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JS559_10435	COG2995	paraquat-inducible protein a
JS559_10450	COG2608	mercury ion transmembrane transporter activity
JS559_10455	COG1979	alcohol dehydrogenase
JS559_10460	COG0583	DNA-binding transcription factor activity
JS559_10465	COG2171	N-acyltransferase activity
JS559_10470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JS559_10480	COG0511	ligase activity, forming carbon-carbon bonds
JS559_10485	COG0439	Biotin carboxylase
JS559_10495	COG3084	Protein conserved in bacteria
JS559_10500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JS559_10510	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS559_10510	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS559_10520	COG1876	peptidase activity
JS559_10525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS559_10530	COG1393	Belongs to the ArsC family
JS559_10540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JS559_10545	COG0564	pseudouridine synthase activity
JS559_10555	COG0668	transmembrane transport
JS559_10560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JS559_10570	COG1025	Belongs to the peptidase M16 family
JS559_10575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JS559_10600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JS559_10605	COG1067	ATP-dependent peptidase activity
JS559_10610	COG3120	sequence-specific DNA binding
JS559_10615	COG0180	Tryptophanyl-tRNA synthetase
JS559_10635	COG0730	response to heat
JS559_10650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JS559_10660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JS559_10665	COG2116	formate transmembrane transporter activity
JS559_10685	COG0484	heat shock protein binding
JS559_10690	COG0443	Heat shock 70 kDa protein
JS559_10695	COG1070	Carbohydrate kinase
JS559_10700	COG2115	Belongs to the xylose isomerase family
JS559_10705	COG4213	ABC transporter substrate-binding protein
JS559_10710	COG1129	ABC transporter
JS559_10715	COG4214	carbohydrate transport
JS559_10720	COG2207	Transcriptional regulator
JS559_10720	COG1609	Transcriptional regulator
JS559_10725	COG3590	peptidase
JS559_10735	COG4145	pantothenate transmembrane transporter activity
JS559_10740	COG3924	membrane
JS559_10745	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
JS559_10750	COG2853	Lipoprotein
JS559_10755	COG0676	glucose-6-phosphate 1-epimerase activity
JS559_10770	COG0726	polysaccharide deacetylase
JS559_10770	COG1649	PFAM Uncharacterised BCR, COG1649
JS559_10775	COG1215	transferase activity, transferring glycosyl groups
JS559_10785	COG0149	triose-phosphate isomerase activity
JS559_10795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JS559_10800	COG1238	metal cluster binding
JS559_10815	COG4942	peptidase
JS559_10815	COG1388	LysM domain
JS559_10820	COG2818	Glycosylase
JS559_10830	COG0700	Nucleoside recognition
JS559_10835	COG3366	ferrous iron transmembrane transporter activity
JS559_10845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JS559_10850	COG0594	ribonuclease P activity
JS559_10855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JS559_10860	COG0174	glutamine synthetase
JS559_10865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JS559_10870	COG0494	nUDIX hydrolase
JS559_10900	COG1490	D-aminoacyl-tRNA deacylase activity
JS559_10905	COG1295	ribonuclease BN
JS559_10910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JS559_10935	COG1064	alcohol dehydrogenase
JS559_10945	COG1923	regulation of RNA biosynthetic process
JS559_10950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JS559_10960	COG1694	Mazg nucleotide pyrophosphohydrolase
JS559_10975	COG1309	transcriptional regulator
JS559_10985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JS559_10990	COG2003	Belongs to the UPF0758 family
JS559_10995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JS559_11000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JS559_11010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JS559_11015	COG0076	glutamate decarboxylase activity
JS559_11020	COG0425	Belongs to the sulfur carrier protein TusA family
JS559_11025	COG2391	methyltransferase activity
JS559_11030	COG3085	chromosome segregation
JS559_11035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JS559_11050	COG0598	Magnesium transport protein CorA
JS559_11055	COG2226	methyltransferase
JS559_11070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JS559_11075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JS559_11080	COG0805	protein transport
JS559_11095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JS559_11100	COG1114	Component of the transport system for branched-chain amino acids
JS559_11105	COG1028	Short-chain dehydrogenase reductase Sdr
JS559_11110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JS559_11115	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JS559_11120	COG0142	geranyltranstransferase activity
JS559_11130	COG0431	NADPH-dependent FMN reductase
JS559_11135	COG2259	Doxx family
JS559_11140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JS559_11145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JS559_11150	COG0697	spore germination
JS559_11155	COG4783	chaperone-mediated protein folding
JS559_11165	COG1040	competence protein
JS559_11170	COG2813	Specifically methylates the guanine in position
JS559_11180	COG0456	acetyltransferase
JS559_11185	COG0513	Belongs to the DEAD box helicase family
JS559_11190	COG0259	pyridoxamine-phosphate oxidase activity
JS559_11195	COG0747	negative chemotaxis
JS559_11205	COG1584	GPR1 FUN34 yaaH family protein
JS559_11210	COG1120	ATPase activity
JS559_11215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JS559_11220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JS559_11245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JS559_11250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JS559_11260	COG0131	Imidazoleglycerol-phosphate dehydratase
JS559_11260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JS559_11270	COG4804	nuclease activity
JS559_11275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JS559_11295	COG0140	phosphoribosyl-ATP diphosphatase activity
JS559_11295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JS559_11300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JS559_11305	COG0024	Methionine aminopeptidase
JS559_11320	COG1621	beta-fructofuranosidase activity
JS559_11325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS559_11335	COG4591	ABC-type transport system involved in lipoprotein release permease component
JS559_11340	COG1136	(ABC) transporter
JS559_11345	COG4591	ABC-type transport system involved in lipoprotein release permease component
JS559_11350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JS559_11380	COG2897	thiosulfate sulfurtransferase activity
JS559_11385	COG2391	methyltransferase activity