locus-tag	class	description
IOD66_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IOD66_00010	COG0592	DNA-directed DNA polymerase activity
IOD66_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IOD66_00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD66_00035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_00040	COG0616	signal peptide processing
IOD66_00045	COG2001	Belongs to the MraZ family
IOD66_00050	COG0275	rRNA processing
IOD66_00055	COG3116	cell division
IOD66_00060	COG0768	penicillin binding
IOD66_00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOD66_00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOD66_00075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOD66_00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IOD66_00085	COG0772	Belongs to the SEDS family
IOD66_00090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IOD66_00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD66_00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD66_00110	COG0849	cell division
IOD66_00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOD66_00120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IOD66_00125	COG0497	DNA recombination
IOD66_00130	COG4172	Belongs to the ABC transporter superfamily
IOD66_00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD66_00140	COG0601	transmembrane transport
IOD66_00150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IOD66_00265	COG2003	Belongs to the UPF0758 family
IOD66_00290	COG0714	Associated with various cellular activities
IOD66_00310	COG0629	single-stranded DNA binding
IOD66_00325	COG0789	Transcriptional regulator
IOD66_00380	COG1902	pentaerythritol trinitrate reductase activity
IOD66_00430	COG0789	Transcriptional regulator
IOD66_00450	COG2356	endonuclease I
IOD66_00480	COG0681	Belongs to the peptidase S26 family
IOD66_00495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_00545	COG1484	DNA-dependent DNA replication
IOD66_00560	COG4584	PFAM Integrase catalytic
IOD66_00605	COG1401	restriction endodeoxyribonuclease activity
IOD66_00610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD66_00625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IOD66_00650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD66_00735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD66_00795	COG0193	aminoacyl-tRNA hydrolase activity
IOD66_00800	COG0012	GTP binding
IOD66_00805	COG2020	methyltransferase activity
IOD66_00815	COG3133	Outer membrane lipoprotein
IOD66_00820	COG3102	Protein conserved in bacteria
IOD66_00825	COG0018	arginyl-trna synthetase
IOD66_00830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IOD66_00840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD66_00845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOD66_00850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOD66_00855	COG0196	riboflavin kinase activity
IOD66_00860	COG3172	ATPase kinase involved in NAD metabolism
IOD66_00865	COG2129	metallophosphoesterase
IOD66_00870	COG0745	RESPONSE REGULATOR receiver
IOD66_00885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IOD66_00890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IOD66_00895	COG1217	gtp-binding protein TYPA
IOD66_00900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD66_00905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IOD66_00910	COG1561	YicC-like family, N-terminal region
IOD66_00915	COG0354	folic acid binding
IOD66_00920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD66_00925	COG2197	response regulator
IOD66_00930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IOD66_00930	COG0116	Belongs to the methyltransferase superfamily
IOD66_00935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOD66_00970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IOD66_00975	COG4133	protoheme IX ABC transporter activity
IOD66_00980	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD66_00985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD66_00990	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOD66_00995	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IOD66_01000	COG1138	Cytochrome C-type biogenesis protein
IOD66_01020	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IOD66_01035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IOD66_01040	COG0792	nuclease activity
IOD66_01045	COG3107	peptidoglycan biosynthetic process
IOD66_01055	COG3101	peptidyl-lysine hydroxylation
IOD66_01060	COG4232	protein-disulfide reductase activity
IOD66_01070	COG3620	sequence-specific DNA binding
IOD66_01080	COG1881	PFAM PEBP family protein
IOD66_01085	COG1126	abc transporter atp-binding protein
IOD66_01090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD66_01095	COG4215	(ABC) transporter
IOD66_01100	COG4160	amino acid transport
IOD66_01110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOD66_01115	COG3099	Belongs to the UPF0263 family
IOD66_01120	COG0742	ribosomal rna small subunit methyltransferase
IOD66_01125	COG0552	protein localization to endoplasmic reticulum
IOD66_01130	COG2884	Cell division ATP-binding protein ftsE
IOD66_01135	COG2177	Part of the ABC transporter FtsEX involved in
IOD66_01140	COG0295	cytidine deaminase activity
IOD66_01145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IOD66_01150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IOD66_01155	COG0308	aminopeptidase N
IOD66_01160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOD66_01200	COG0375	protein maturation
IOD66_01205	COG0298	carbon dioxide binding
IOD66_01210	COG1773	rubredoxin
IOD66_01215	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IOD66_01220	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IOD66_01225	COG5557	Pfam Polysulphide reductase, NrfD
IOD66_01230	COG0437	4 iron, 4 sulfur cluster binding
IOD66_01235	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IOD66_01240	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOD66_01245	COG0309	Hydrogenase expression formation protein (HypE)
IOD66_01250	COG0409	Hydrogenase expression formation protein
IOD66_01255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD66_01260	COG0210	DNA helicase
IOD66_01265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD66_01270	COG2190	(PTS) system
IOD66_01275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD66_01280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_01285	COG1178	ABC-type Fe3 transport system permease component
IOD66_01290	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IOD66_01300	COG0549	Belongs to the carbamate kinase family
IOD66_01305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IOD66_01310	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD66_01315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IOD66_01320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOD66_01325	COG0494	nUDIX hydrolase
IOD66_01330	COG1218	3'(2'),5'-bisphosphate nucleotidase
IOD66_01335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IOD66_01340	COG0363	glucosamine-6-phosphate deaminase activity
IOD66_01345	COG2814	Major facilitator Superfamily
IOD66_01355	COG4804	nuclease activity
IOD66_01365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IOD66_01380	COG3115	cell septum assembly
IOD66_01385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOD66_01395	COG2814	Major facilitator Superfamily
IOD66_01405	COG0563	adenylate kinase activity
IOD66_01415	COG0039	L-malate dehydrogenase activity
IOD66_01420	COG1438	arginine binding
IOD66_01425	COG1090	epimerase
IOD66_01430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD66_01435	COG1127	ABC transporter
IOD66_01440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOD66_01445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOD66_01450	COG2854	intermembrane phospholipid transfer
IOD66_01460	COG5007	Belongs to the BolA IbaG family
IOD66_01465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOD66_01480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD66_01485	COG0488	(ABC) transporter
IOD66_01505	COG2166	iron-sulfur cluster assembly
IOD66_01510	COG0740	serine-type endopeptidase activity
IOD66_01515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IOD66_01520	COG1663	tetraacyldisaccharide 4'-kinase activity
IOD66_01525	COG2835	tetraacyldisaccharide 4'-kinase activity
IOD66_01530	COG4115	mRNA cleavage
IOD66_01535	COG2161	toxin-antitoxin pair type II binding
IOD66_01570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IOD66_01575	COG3063	Type IV pilus biogenesis stability protein PilW
IOD66_01580	COG2183	response to ionizing radiation
IOD66_01585	COG1252	NADH dehydrogenase
IOD66_01595	COG3719	Belongs to the RNase T2 family
IOD66_01600	COG0616	signal peptide processing
IOD66_01605	COG0778	Nitroreductase
IOD66_01610	COG0300	oxidoreductase activity
IOD66_01620	COG2217	Heavy metal translocating P-type atpase
IOD66_01630	COG0789	Transcriptional regulator
IOD66_01655	COG0745	RESPONSE REGULATOR receiver
IOD66_01660	COG5002	protein histidine kinase activity
IOD66_01665	COG0187	DNA topoisomerase II activity
IOD66_01670	COG0471	metal ion transport
IOD66_01675	COG0471	metal ion transport
IOD66_01680	COG0471	metal ion transport
IOD66_01685	COG0126	phosphoglycerate kinase activity
IOD66_01690	COG0191	fructose-bisphosphate aldolase activity
IOD66_01695	COG4172	Belongs to the ABC transporter superfamily
IOD66_01710	COG0778	Nitroreductase
IOD66_01725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD66_01730	COG0084	hydrolase, TatD family'
IOD66_01735	COG1966	Carbon starvation protein
IOD66_01740	COG1640	4-alpha-glucanotransferase
IOD66_01745	COG3833	ABC-type maltose transport systems, permease component
IOD66_01760	COG3842	ATPase activity
IOD66_01765	COG4580	involved in the transport of maltose and maltodextrins
IOD66_01775	COG2909	trisaccharide binding
IOD66_01780	COG0058	SHG alpha-glucan phosphorylase activity
IOD66_01790	COG1666	GTP binding
IOD66_01795	COG0560	Phosphoserine phosphatase
IOD66_01805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IOD66_01815	COG2081	HI0933 family
IOD66_01820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOD66_01825	COG2252	PERMEase
IOD66_01830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOD66_01835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD66_01845	COG0716	FMN binding
IOD66_01850	COG0735	belongs to the Fur family
IOD66_01855	COG3008	intermembrane lipid transfer
IOD66_01860	COG1854	S-ribosylhomocysteine lyase activity
IOD66_01865	COG1132	(ABC) transporter
IOD66_01880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD66_01885	COG1275	C4-dicarboxylate transporter malic acid transport protein
IOD66_01900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOD66_01905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IOD66_01920	COG0625	glutathione transferase activity
IOD66_01950	COG2095	MarC family integral membrane protein
IOD66_01955	COG0778	Nitroreductase
IOD66_01960	COG2084	Dehydrogenase
IOD66_01965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD66_01985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOD66_01990	COG1902	pentaerythritol trinitrate reductase activity
IOD66_02035	COG1373	ATPase (AAA superfamily
IOD66_02040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD66_02040	COG0475	glutathione-regulated potassium exporter activity
IOD66_02045	COG0673	inositol 2-dehydrogenase activity
IOD66_02050	COG0165	Argininosuccinate lyase
IOD66_02055	COG0659	secondary active sulfate transmembrane transporter activity
IOD66_02060	COG1426	Protein conserved in bacteria
IOD66_02065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IOD66_02075	COG2976	Protein conserved in bacteria
IOD66_02080	COG3201	nicotinamide mononucleotide transporter
IOD66_02095	COG2965	DNA replication, synthesis of RNA primer
IOD66_02105	COG0359	binds to the 23S rRNA
IOD66_02110	COG2841	Protein conserved in bacteria
IOD66_02115	COG2268	Band 7 protein
IOD66_02120	COG2226	methyltransferase
IOD66_02125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOD66_02130	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD66_02135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOD66_02140	COG2837	iron assimilation
IOD66_02150	COG0009	L-threonylcarbamoyladenylate synthase
IOD66_02155	COG1187	pseudouridine synthase activity
IOD66_02165	COG3266	domain, Protein
IOD66_02170	COG0583	DNA-binding transcription factor activity
IOD66_02180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD66_02185	COG0612	Peptidase, M16
IOD66_02190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IOD66_02200	COG0217	transcriptional regulatory protein
IOD66_02205	COG0494	nUDIX hydrolase
IOD66_02210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IOD66_02220	COG0512	Glutamine amidotransferase of anthranilate synthase
IOD66_02225	COG1322	Protein conserved in bacteria
IOD66_02225	COG1322	Protein conserved in bacteria
IOD66_02235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD66_02240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IOD66_02245	COG2137	regulation of response to DNA damage stimulus
IOD66_02255	COG0551	DNA topoisomerase type I activity
IOD66_02265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOD66_02290	COG2960	long-chain fatty acid transporting porin activity
IOD66_02295	COG0166	Belongs to the GPI family
IOD66_02300	COG1388	LysM domain
IOD66_02300	COG0860	N-Acetylmuramoyl-L-alanine amidase
IOD66_02305	COG0802	atpase or kinase
IOD66_02310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IOD66_02315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IOD66_02320	COG1519	Transferase
IOD66_02325	COG3307	-O-antigen
IOD66_02330	COG0826	peptidase U32
IOD66_02340	COG0628	permease
IOD66_02345	COG1115	amino acid carrier protein
IOD66_02350	COG1525	nuclease
IOD66_02355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOD66_02360	COG0205	6-phosphofructokinase activity
IOD66_02370	COG0564	pseudouridine synthase activity
IOD66_02375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD66_02380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IOD66_02395	COG1965	Belongs to the frataxin family
IOD66_02405	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
IOD66_02410	COG1051	belongs to the nudix hydrolase family
IOD66_02415	COG0148	phosphopyruvate hydratase activity
IOD66_02420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD66_02425	COG1472	Belongs to the glycosyl hydrolase 3 family
IOD66_02430	COG0861	Integral membrane protein TerC family
IOD66_02435	COG3066	DNA modification
IOD66_02440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOD66_02445	COG2937	Belongs to the GPAT DAPAT family
IOD66_02450	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IOD66_02460	COG0795	lipopolysaccharide-transporting ATPase activity
IOD66_02465	COG0795	lipopolysaccharide-transporting ATPase activity
IOD66_02475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IOD66_02490	COG0602	queuosine metabolic process
IOD66_02495	COG0720	synthase
IOD66_02505	COG3583	domain protein
IOD66_02505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IOD66_02505	COG3064	Membrane
IOD66_02510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IOD66_02515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD66_02530	COG1027	Aspartate ammonia-lyase
IOD66_02540	COG1393	Belongs to the ArsC family
IOD66_02545	COG0798	PFAM Bile acid sodium symporter
IOD66_02550	COG0542	response to heat
IOD66_02555	COG3047	cAMP biosynthetic process
IOD66_02570	COG0531	amino acid
IOD66_02575	COG0531	amino acid
IOD66_02585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IOD66_02595	COG3118	belongs to the thioredoxin family
IOD66_02600	COG0330	HflC and HflK could
IOD66_02605	COG0330	HflC and HflK could
IOD66_02610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOD66_02615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD66_02615	COG0301	tRNA thio-modification
IOD66_02625	COG0424	maF-like protein
IOD66_02630	COG2252	PERMEase
IOD66_02635	COG1528	Iron-storage protein
IOD66_02640	COG1528	Iron-storage protein
IOD66_02645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD66_02650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOD66_02655	COG1862	Preprotein translocase
IOD66_02660	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IOD66_02665	COG0642	Histidine kinase
IOD66_02670	COG0745	RESPONSE REGULATOR receiver
IOD66_02685	COG3111	PFAM Bacterial OB fold (BOF) protein
IOD66_02695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOD66_02705	COG0475	glutathione-regulated potassium exporter activity
IOD66_02705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOD66_02710	COG1138	Cytochrome C-type biogenesis protein
IOD66_02715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD66_02720	COG3088	subunit of a heme lyase
IOD66_02720	COG4235	cytochrome complex assembly
IOD66_02730	COG0748	coenzyme F420 binding
IOD66_02735	COG4771	TonB-dependent receptor
IOD66_02735	COG1629	transport
IOD66_02740	COG1280	lysine exporter protein (LysE YggA)
IOD66_02745	COG2962	Rard protein
IOD66_02750	COG2962	Rard protein
IOD66_02755	COG0436	Aminotransferase
IOD66_02760	COG1169	isochorismate synthase
IOD66_02765	COG2431	L-lysine efflux transmembrane transporter activity
IOD66_02770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOD66_02775	COG0501	Belongs to the peptidase M48B family
IOD66_02780	COG1238	metal cluster binding
IOD66_02785	COG2116	formate transmembrane transporter activity
IOD66_02790	COG1882	Formate acetyltransferase
IOD66_02795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IOD66_02800	COG0339	signal peptide processing
IOD66_02805	COG1605	Chorismate mutase
IOD66_02805	COG0077	Prephenate dehydratase
IOD66_02810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOD66_02815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD66_02820	COG5039	Polysaccharide pyruvyl transferase
IOD66_02830	COG3306	glycosyltransferase involved in LPS biosynthesis
IOD66_02840	COG1216	Glycosyl transferase, family 2
IOD66_02845	COG1216	Glycosyl transferase, family 2
IOD66_02850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD66_02850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOD66_02860	COG2186	Transcriptional regulator
IOD66_02870	COG1904	glucuronate isomerase
IOD66_02875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD66_02880	COG0800	Aldolase
IOD66_02885	COG2364	Membrane
IOD66_02890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IOD66_02895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IOD66_02900	COG0813	purine-nucleoside phosphorylase activity
IOD66_02905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IOD66_02910	COG0459	protein refolding
IOD66_02915	COG1012	belongs to the aldehyde dehydrogenase family
IOD66_02915	COG1454	alcohol dehydrogenase
IOD66_02920	COG0181	hydroxymethylbilane synthase activity
IOD66_02930	COG2959	enzyme of heme biosynthesis
IOD66_02935	COG3071	HemY protein
IOD66_02940	COG2354	Protein conserved in bacteria
IOD66_02945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IOD66_02955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD66_02960	COG2095	MarC family integral membrane protein
IOD66_02970	COG0489	protein tyrosine kinase activity
IOD66_02990	COG2017	converts alpha-aldose to the beta-anomer
IOD66_02995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IOD66_03000	COG1085	galactose-1-phosphate uridylyltransferase
IOD66_03005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD66_03010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD66_03015	COG1408	metallophosphoesterase
IOD66_03025	COG0753	catalase activity
IOD66_03030	COG0326	Molecular chaperone. Has ATPase activity
IOD66_03045	COG0254	rRNA binding
IOD66_03065	COG0583	DNA-binding transcription factor activity
IOD66_03070	COG0708	Exodeoxyribonuclease III
IOD66_03080	COG0037	tRNA processing
IOD66_03085	COG3092	negative regulation of chromosome organization
IOD66_03100	COG1607	acyl-coa hydrolase
IOD66_03105	COG2350	Protein conserved in bacteria
IOD66_03115	COG3112	Uncharacterised protein family (UPF0231)
IOD66_03120	COG0786	glutamate:sodium symporter activity
IOD66_03125	COG0569	domain protein
IOD66_03125	COG2985	domain, Protein
IOD66_03130	COG3078	GTPase activator activity
IOD66_03140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD66_03145	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IOD66_03150	COG2831	hemolysin activation secretion protein
IOD66_03155	COG2831	hemolysin activation secretion protein
IOD66_03160	COG3210	domain, Protein
IOD66_03180	COG0138	bifunctional purine biosynthesis protein purh
IOD66_03185	COG1444	tRNA N-acetyltransferase activity
IOD66_03220	COG3620	sequence-specific DNA binding
IOD66_03225	COG2856	Zn peptidase
IOD66_03235	COG2801	Transposase and inactivated derivatives
IOD66_03255	COG2027	D-alanyl-D-alanine carboxypeptidase
IOD66_03260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOD66_03270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOD66_03275	COG0156	8-amino-7-oxononanoate synthase activity
IOD66_03280	COG2830	Protein of unknown function (DUF452)
IOD66_03285	COG2226	methyltransferase
IOD66_03290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD66_03295	COG2840	Smr protein MutS2
IOD66_03300	COG0697	spore germination
IOD66_03305	COG5002	protein histidine kinase activity
IOD66_03305	COG2198	Histidine kinase
IOD66_03305	COG0784	Response regulator, receiver
IOD66_03310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOD66_03320	COG1959	2 iron, 2 sulfur cluster binding
IOD66_03325	COG1104	cysteine desulfurase activity
IOD66_03330	COG0822	iron-sulfur transferase activity
IOD66_03340	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IOD66_03355	COG0443	Heat shock 70 kDa protein
IOD66_03360	COG0633	Ferredoxin
IOD66_03365	COG2975	iron-sulfur cluster assembly
IOD66_03400	COG0617	tRNA 3'-terminal CCA addition
IOD66_03405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOD66_03410	COG0215	cysteine-tRNA ligase activity
IOD66_03415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOD66_03435	COG0583	DNA-binding transcription factor activity
IOD66_03445	COG0110	maltose O-acetyltransferase activity
IOD66_03455	COG3642	lipopolysaccharide core region biosynthetic process
IOD66_03460	COG0302	gtp cyclohydrolase
IOD66_03470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IOD66_03475	COG1560	Kdo2-lipid A biosynthetic process
IOD66_03480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD66_03490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOD66_03505	COG3058	Necessary for formate dehydrogenase activity
IOD66_03510	COG2864	formate dehydrogenase
IOD66_03515	COG0437	4 iron, 4 sulfur cluster binding
IOD66_03525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOD66_03540	COG1024	Enoyl-CoA hydratase
IOD66_03540	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOD66_03550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOD66_03555	COG0730	response to heat
IOD66_03560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IOD66_03565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOD66_03575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOD66_03580	COG4969	Belongs to the N-Me-Phe pilin family
IOD66_03585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOD66_03590	COG1459	type II secretion system
IOD66_03600	COG0237	dephospho-CoA kinase activity
IOD66_03605	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IOD66_03610	COG1466	dna polymerase III delta subunit
IOD66_03615	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IOD66_03620	COG0495	leucyl-tRNA aminoacylation
IOD66_03625	COG3340	Belongs to the peptidase S51 family
IOD66_03630	COG3069	C4-dicarboxylate transmembrane transporter activity
IOD66_03635	COG1473	amidohydrolase
IOD66_03640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IOD66_03645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IOD66_03650	COG3106	COG3106 Predicted ATPase
IOD66_03655	COG3025	triphosphatase activity
IOD66_03665	COG3140	Belongs to the UPF0181 family
IOD66_03670	COG0564	pseudouridine synthase activity
IOD66_03675	COG3098	single-species biofilm formation
IOD66_03680	COG3177	Filamentation induced by cAMP protein fic
IOD66_03685	COG0135	phosphoribosylanthranilate isomerase activity
IOD66_03685	COG0134	indole-3-glycerol-phosphate synthase activity
IOD66_03690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IOD66_03690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOD66_03695	COG1760	l-serine dehydratase
IOD66_03700	COG0814	amino acid
IOD66_03705	COG0747	negative chemotaxis
IOD66_03715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD66_03725	COG4608	Belongs to the ABC transporter superfamily
IOD66_03730	COG0444	Belongs to the ABC transporter superfamily
IOD66_03740	COG4166	transmembrane transport
IOD66_03745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOD66_03750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOD66_03755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOD66_03760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IOD66_03760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IOD66_03765	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IOD66_03770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOD66_03775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IOD66_03785	COG0842	Transport permease protein
IOD66_03790	COG1129	ABC transporter
IOD66_03790	COG0842	Transport permease protein
IOD66_03795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_03800	COG1309	transcriptional regulator
IOD66_03805	COG0717	Belongs to the dCTP deaminase family
IOD66_03810	COG0572	uridine kinase
IOD66_03820	COG0588	phosphoglycerate mutase activity
IOD66_03825	COG4942	peptidase
IOD66_03830	COG2861	carbohydrate metabolic process
IOD66_03835	COG0729	surface antigen
IOD66_03840	COG2911	Protein conserved in bacteria
IOD66_03845	COG4988	ABC transporter
IOD66_03850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IOD66_03855	COG2915	High frequency lysogenization protein hflD homolog
IOD66_03860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOD66_03865	COG1349	DNA-binding transcription factor activity
IOD66_03870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOD66_03875	COG0187	DNA topoisomerase II activity
IOD66_03880	COG0586	Pfam SNARE associated Golgi protein
IOD66_03885	COG1609	Transcriptional regulator
IOD66_03890	COG2351	hydroxyisourate hydrolase activity
IOD66_03910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IOD66_03920	COG0500	methyltransferase
IOD66_03935	COG1944	ATP diphosphatase activity
IOD66_03940	COG1530	ribonuclease E activity
IOD66_03945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IOD66_03955	COG0142	geranyltranstransferase activity
IOD66_03960	COG1722	exodeoxyribonuclease VII activity
IOD66_03965	COG3217	Mosc domain protein beta barrel domain protein
IOD66_03965	COG0633	Ferredoxin
IOD66_03970	COG1368	sulfuric ester hydrolase activity
IOD66_03980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IOD66_03985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IOD66_03990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IOD66_03995	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IOD66_04005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IOD66_04010	COG3283	Transcriptional regulator of aromatic amino acids metabolism
IOD66_04015	COG4166	transmembrane transport
IOD66_04020	COG4168	peptide transport system, permease
IOD66_04025	COG4171	peptide transport system, permease
IOD66_04030	COG4172	Belongs to the ABC transporter superfamily
IOD66_04035	COG2315	Protein conserved in bacteria
IOD66_04050	COG2070	2-Nitropropane dioxygenase
IOD66_04085	COG0629	single-stranded DNA binding
IOD66_04090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOD66_04100	COG1199	ATP-dependent helicase activity
IOD66_04110	COG1346	cytolysis
IOD66_04115	COG1132	(ABC) transporter
IOD66_04120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IOD66_04130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOD66_04135	COG0167	dihydroorotate dehydrogenase activity
IOD66_04140	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IOD66_04145	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD66_04150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOD66_04180	COG0737	Belongs to the 5'-nucleotidase family
IOD66_04185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IOD66_04190	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IOD66_04195	COG0658	competence protein
IOD66_04195	COG2333	competence protein COMEC
IOD66_04200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IOD66_04215	COG2226	methyltransferase
IOD66_04220	COG3036	rescue of stalled ribosome
IOD66_04230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOD66_04235	COG1346	cytolysis
IOD66_04240	COG1380	Effector of murein hydrolase LrgA
IOD66_04245	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IOD66_04260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IOD66_04265	COG2226	methyltransferase
IOD66_04270	COG0596	Alpha beta hydrolase
IOD66_04275	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IOD66_04280	COG0318	PFAM AMP-dependent synthetase and ligase
IOD66_04285	COG3264	Mechanosensitive ion channel
IOD66_04285	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IOD66_04290	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IOD66_04290	COG3264	Mechanosensitive ion channel
IOD66_04295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IOD66_04300	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IOD66_04315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD66_04325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOD66_04335	COG0539	negative regulation of cytoplasmic translation
IOD66_04340	COG0776	regulation of translation
IOD66_04345	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IOD66_04350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IOD66_04355	COG0284	orotidine-5'-phosphate decarboxylase activity
IOD66_04360	COG0023	Translation Initiation Factor
IOD66_04365	COG3787	Belongs to the UPF0306 family
IOD66_04370	COG1811	Na channel or pump
IOD66_04380	COG3094	Invasion gene expression up-regulator, SirB
IOD66_04385	COG3028	Belongs to the UPF0307 family
IOD66_04390	COG0312	modulator of DNA gyrase
IOD66_04395	COG0440	acetolactate synthase activity
IOD66_04400	COG0028	Belongs to the TPP enzyme family
IOD66_04405	COG0288	reversible hydration of carbon dioxide
IOD66_04410	COG1278	Cold shock
IOD66_04420	COG0343	queuine tRNA-ribosyltransferase activity
IOD66_04425	COG3945	hemerythrin HHE cation binding domain
IOD66_04435	COG4991	sh3 domain protein
IOD66_04440	COG0306	phosphate transporter
IOD66_04445	COG1392	Phosphate transport regulator
IOD66_04450	COG4604	ABC transporter, ATP-binding protein
IOD66_04455	COG4605	iron ion homeostasis
IOD66_04460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOD66_04465	COG4607	ABC-type enterochelin transport system periplasmic component
IOD66_04470	COG0305	Participates in initiation and elongation during chromosome replication
IOD66_04475	COG3100	YcgL domain-containing protein
IOD66_04480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IOD66_04485	COG0527	aspartate kinase activity
IOD66_04490	COG2926	Belongs to the UPF0265 family
IOD66_04495	COG0248	Ppx GppA phosphatase
IOD66_04500	COG2731	YhcH YjgK YiaL family protein
IOD66_04505	COG1737	Transcriptional regulator
IOD66_04520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD66_04525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IOD66_04540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOD66_04545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD66_04545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IOD66_04560	COG1444	tRNA N-acetyltransferase activity
IOD66_04565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IOD66_04570	COG0314	molybdopterin synthase activity
IOD66_04575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IOD66_04580	COG0315	cyclic pyranopterin monophosphate synthase activity
IOD66_04585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOD66_04590	COG3005	denitrification pathway
IOD66_04595	COG0243	molybdopterin cofactor binding
IOD66_04600	COG0277	FAD linked oxidase domain protein
IOD66_04605	COG2363	Small membrane protein
IOD66_04610	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IOD66_04615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IOD66_04620	COG0626	cystathionine gamma-synthase activity
IOD66_04625	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IOD66_04630	COG0741	lytic transglycosylase activity
IOD66_04635	COG2814	Major facilitator Superfamily
IOD66_04645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOD66_04650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IOD66_04660	COG1509	lysine 2,3-aminomutase activity
IOD66_04665	COG0017	Asparaginyl-tRNA synthetase
IOD66_04670	COG0038	chloride channel
IOD66_04675	COG2925	Exonuclease
IOD66_04685	COG0613	PHP domain protein
IOD66_04695	COG2837	iron assimilation
IOD66_04700	COG2822	iron ion transport
IOD66_04705	COG0556	nucleotide-excision repair
IOD66_04715	COG1487	ribonuclease activity
IOD66_04725	COG0006	proline dipeptidase activity
IOD66_04730	COG1448	Aminotransferase
IOD66_04735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOD66_04745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IOD66_04750	COG0625	glutathione transferase activity
IOD66_04755	COG2969	positive regulation of protein catabolic process
IOD66_04765	COG0589	response to stress
IOD66_04775	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IOD66_04785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOD66_04805	COG0737	Belongs to the 5'-nucleotidase family
IOD66_04815	COG0857	belongs to the CobB CobQ family
IOD66_04815	COG0280	phosphate acetyltransferase
IOD66_04825	COG2951	lytic endotransglycosylase activity
IOD66_04830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOD66_04835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IOD66_04840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IOD66_04845	COG0195	Participates in both transcription termination and antitermination
IOD66_04850	COG0779	Required for maturation of 30S ribosomal subunits
IOD66_04860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IOD66_04870	COG0732	type I restriction modification DNA specificity domain
IOD66_04875	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IOD66_04880	COG0285	dihydrofolate synthase activity
IOD66_04890	COG3956	TIGRFAM MazG family protein
IOD66_04895	COG0745	RESPONSE REGULATOR receiver
IOD66_04905	COG1136	(ABC) transporter
IOD66_04905	COG0577	efflux transmembrane transporter activity
IOD66_04910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOD66_04915	COG1494	fructose-1,6-bisphosphatase
IOD66_04920	COG3074	FtsZ-dependent cytokinesis
IOD66_04925	COG1435	thymidine kinase activity
IOD66_04930	COG1214	PFAM Peptidase M22, glycoprotease
IOD66_04935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD66_04940	COG2321	neutral zinc metallopeptidase
IOD66_04945	COG1674	ftsk spoiiie
IOD66_04950	COG1522	sequence-specific DNA binding
IOD66_04955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IOD66_04960	COG1940	carbohydrate kinase activity
IOD66_04960	COG1846	Transcriptional regulator
IOD66_04965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOD66_04975	COG0791	NLP P60 protein
IOD66_04980	COG0776	regulation of translation
IOD66_04985	COG0072	phenylalanine-tRNA ligase activity
IOD66_04990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IOD66_04995	COG0778	Nitroreductase
IOD66_05000	COG1823	symporter activity
IOD66_05020	COG3022	response to hydroperoxide
IOD66_05030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IOD66_05035	COG3105	Protein conserved in bacteria
IOD66_05045	COG0814	amino acid
IOD66_05055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOD66_05060	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IOD66_05065	COG0517	IMP dehydrogenase activity
IOD66_05065	COG0516	GMP reductase activity
IOD66_05080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD66_05085	COG3955	Domain of unknown function (DUF1919)
IOD66_05095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOD66_05100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOD66_05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_05110	COG1309	transcriptional regulator
IOD66_05115	COG3082	Protein of unknown function (DUF1414)
IOD66_05120	COG3083	sulfuric ester hydrolase activity
IOD66_05130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IOD66_05135	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IOD66_05145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD66_05150	COG1185	polyribonucleotide nucleotidyltransferase activity
IOD66_05155	COG4785	May be involved in cell division
IOD66_05160	COG0513	Belongs to the DEAD box helicase family
IOD66_05165	COG0590	tRNA wobble adenosine to inosine editing
IOD66_05170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IOD66_05175	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IOD66_05180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOD66_05185	COG0233	cytoplasmic translational termination
IOD66_05190	COG0528	UMP kinase activity
IOD66_05195	COG2194	sulfuric ester hydrolase activity
IOD66_05200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IOD66_05225	COG1840	ABC-type Fe3 transport system, periplasmic component
IOD66_05230	COG0433	COG0433 Predicted ATPase
IOD66_05265	COG1381	Involved in DNA repair and RecF pathway recombination
IOD66_05270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOD66_05275	COG0571	ribonuclease III activity
IOD66_05280	COG0681	Belongs to the peptidase S26 family
IOD66_05285	COG0481	GTPase activity
IOD66_05300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOD66_05305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOD66_05310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOD66_05320	COG2104	thiamine diphosphate biosynthetic process
IOD66_05330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOD66_05340	COG1115	amino acid carrier protein
IOD66_05345	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IOD66_05350	COG3683	transport system, periplasmic component
IOD66_05365	COG0281	malic enzyme
IOD66_05365	COG0280	phosphate acetyltransferase
IOD66_05370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IOD66_05375	COG0189	ligase activity
IOD66_05385	COG0640	Transcriptional regulator
IOD66_05410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOD66_05415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD66_05425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IOD66_05440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD66_05440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IOD66_05455	COG0159	tryptophan synthase activity
IOD66_05460	COG0133	tryptophan synthase activity
IOD66_05465	COG4221	oxidoreductase activity
IOD66_05475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IOD66_05480	COG0393	Putative heavy-metal-binding
IOD66_05485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IOD66_05495	COG3850	Histidine kinase
IOD66_05500	COG0561	phosphatase activity
IOD66_05510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOD66_05515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_05520	COG0739	heme binding
IOD66_05525	COG1121	(ABC) transporter
IOD66_05530	COG0567	Dehydrogenase, E1 component
IOD66_05535	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOD66_05540	COG2990	Protein conserved in bacteria
IOD66_05545	COG0045	succinate-CoA ligase (ADP-forming) activity
IOD66_05550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IOD66_05555	COG1879	ABC-type sugar transport system periplasmic component
IOD66_05560	COG1757	Na H antiporter
IOD66_05565	COG2916	Histone family protein nucleoid-structuring protein H-NS
IOD66_05570	COG1620	l-lactate permease
IOD66_05575	COG0247	lactate metabolic process
IOD66_05580	COG1139	Iron-sulfur cluster binding protein
IOD66_05585	COG1556	Lactate utilization protein
IOD66_05605	COG2949	membrane
IOD66_05610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOD66_05615	COG0121	glutamine amidotransferase
IOD66_05620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD66_05625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOD66_05630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IOD66_05635	COG1792	Involved in formation and maintenance of cell shape
IOD66_05645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOD66_05660	COG5645	(Lipo)protein
IOD66_05670	COG1496	oxidoreductase activity
IOD66_05675	COG0251	oxidation-reduction process
IOD66_05680	COG3081	Nucleoid-associated protein
IOD66_05685	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOD66_05690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOD66_05700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IOD66_05705	COG1286	toxin biosynthetic process
IOD66_05710	COG0328	RNA-DNA hybrid ribonuclease activity
IOD66_05720	COG0859	PFAM glycosyl transferase family 9
IOD66_05725	COG1686	Belongs to the peptidase S11 family
IOD66_05730	COG0463	Glycosyl transferase, family 2
IOD66_05735	COG1534	Rna-binding protein
IOD66_05740	COG0671	phosphoesterase, PA-phosphatase related
IOD66_05750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD66_05755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOD66_05760	COG0575	Belongs to the CDS family
IOD66_05765	COG0750	zinc metalloprotease
IOD66_05780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_05785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD66_05790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_05795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IOD66_05800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD66_05805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IOD66_05810	COG1160	GTP binding
IOD66_05815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IOD66_05815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IOD66_05820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IOD66_05825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOD66_05830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOD66_05835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IOD66_05840	COG0318	PFAM AMP-dependent synthetase and ligase
IOD66_05850	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IOD66_05855	COG1595	DNA-templated transcription, initiation
IOD66_05865	COG0561	phosphatase activity
IOD66_05870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_05875	COG0385	Bile acid
IOD66_05880	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IOD66_05890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOD66_05890	COG0517	IMP dehydrogenase activity
IOD66_05905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD66_05905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOD66_05920	COG0247	lactate metabolic process
IOD66_05925	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
IOD66_05930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IOD66_05935	COG0584	glycerophosphoryl diester phosphodiesterase
IOD66_05940	COG2271	Major facilitator Superfamily
IOD66_05945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOD66_05950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOD66_05955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD66_05965	COG4535	Mg2 and Co2 transporter CorC
IOD66_05970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IOD66_05975	COG1074	ATP-dependent DNA helicase activity
IOD66_05980	COG0534	Mate efflux family protein
IOD66_05985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IOD66_05990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IOD66_05995	COG2707	UPF0756 membrane protein
IOD66_06000	COG1643	Atp-dependent helicase
IOD66_06010	COG2990	Protein conserved in bacteria
IOD66_06015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IOD66_06020	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IOD66_06025	COG2932	Transcriptional regulator
IOD66_06030	COG0791	NLP P60 protein
IOD66_06035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IOD66_06040	COG3381	protein complex oligomerization
IOD66_06050	COG2814	Major facilitator Superfamily
IOD66_06055	COG1187	pseudouridine synthase activity
IOD66_06070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD66_06070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOD66_06075	COG0105	UTP biosynthetic process
IOD66_06080	COG0058	SHG alpha-glucan phosphorylase activity
IOD66_06085	COG0297	glycogen (starch) synthase activity
IOD66_06090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IOD66_06095	COG1523	belongs to the glycosyl hydrolase 13 family
IOD66_06100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IOD66_06105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_06105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_06110	COG1105	Belongs to the carbohydrate kinase PfkB family
IOD66_06115	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOD66_06115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD66_06115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOD66_06120	COG1704	LemA family
IOD66_06130	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IOD66_06135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IOD66_06145	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IOD66_06150	COG1137	ATPase activity
IOD66_06155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_06160	COG1660	Displays ATPase and GTPase activities
IOD66_06165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD66_06185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD66_06210	COG1702	phosphate starvation-inducible protein PhoH
IOD66_06225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IOD66_06230	COG0626	cystathionine gamma-synthase activity
IOD66_06235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOD66_06240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IOD66_06245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IOD66_06250	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOD66_06255	COG0564	pseudouridine synthase activity
IOD66_06260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IOD66_06265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IOD66_06270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD66_06280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IOD66_06285	COG0303	'Molybdopterin
IOD66_06295	COG0488	(ABC) transporter
IOD66_06305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD66_06310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IOD66_06325	COG0823	Involved in the tonB-independent uptake of proteins
IOD66_06330	COG3064	Membrane
IOD66_06330	COG3064	Membrane
IOD66_06335	COG0848	biopolymer transport protein
IOD66_06340	COG0811	peptide transport
IOD66_06345	COG0824	Thioesterase
IOD66_06360	COG1294	oxidase, subunit
IOD66_06365	COG1271	oxidase subunit
IOD66_06375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOD66_06380	COG0488	(ABC) transporter
IOD66_06410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOD66_06415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOD66_06420	COG2255	four-way junction helicase activity
IOD66_06425	COG0632	four-way junction helicase activity
IOD66_06430	COG1177	transmembrane transport
IOD66_06435	COG1176	ABC-type spermidine putrescine transport system, permease component I
IOD66_06440	COG3842	ATPase activity
IOD66_06445	COG0210	DNA helicase
IOD66_06450	COG0084	hydrolase, TatD family'
IOD66_06455	COG0322	excinuclease ABC activity
IOD66_06465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOD66_06470	COG0670	Belongs to the BI1 family
IOD66_06475	COG2920	part of a sulfur-relay system
IOD66_06485	COG1121	(ABC) transporter
IOD66_06490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOD66_06495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD66_06500	COG0251	oxidation-reduction process
IOD66_06510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOD66_06515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IOD66_06520	COG1131	(ABC) transporter
IOD66_06525	COG0842	Transport permease protein
IOD66_06530	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOD66_06535	COG4149	molybdate abc transporter
IOD66_06540	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IOD66_06545	COG2867	negative regulation of translational initiation
IOD66_06550	COG2914	Belongs to the UPF0125 (RnfH) family
IOD66_06555	COG1538	Outer membrane efflux protein
IOD66_06560	COG0194	GDP metabolic process
IOD66_06565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IOD66_06570	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOD66_06595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD66_06600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOD66_06605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOD66_06610	COG0527	aspartate kinase activity
IOD66_06610	COG0460	homoserine dehydrogenase
IOD66_06615	COG0083	homoserine kinase activity
IOD66_06620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOD66_06625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOD66_06640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOD66_06645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IOD66_06650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IOD66_06655	COG0494	nUDIX hydrolase
IOD66_06665	COG0653	protein targeting
IOD66_06690	COG0271	Belongs to the BolA IbaG family
IOD66_06700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOD66_06705	COG1678	Uncharacterized ACR, COG1678
IOD66_06710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOD66_06715	COG0588	phosphoglycerate mutase activity
IOD66_06720	COG0564	pseudouridine synthase activity
IOD66_06725	COG1253	flavin adenine dinucleotide binding
IOD66_06740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IOD66_06745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IOD66_06750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IOD66_06770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IOD66_06805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOD66_06810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IOD66_06820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IOD66_06830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOD66_06835	COG1280	lysine exporter protein (LysE YggA)
IOD66_06840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOD66_06845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IOD66_06850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IOD66_06855	COG4796	Type ii and iii secretion system protein
IOD66_06875	COG4972	Pilus assembly protein
IOD66_06880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IOD66_06885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOD66_06890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IOD66_06895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IOD66_06900	COG0733	neurotransmitter:sodium symporter activity
IOD66_06905	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IOD66_06910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD66_06915	COG2062	phosphohistidine phosphatase, SixA
IOD66_06920	COG0469	pyruvate kinase activity
IOD66_06925	COG0859	PFAM glycosyl transferase family 9
IOD66_06930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOD66_06935	COG0287	Prephenate dehydrogenase
IOD66_06935	COG1605	Chorismate mutase
IOD66_06945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOD66_06950	COG0346	lactoylglutathione lyase activity
IOD66_06960	COG2911	Protein conserved in bacteria
IOD66_06970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOD66_06975	COG0617	tRNA 3'-terminal CCA addition
IOD66_06980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOD66_06985	COG4143	(ABC) transporter
IOD66_06990	COG0402	S-adenosylhomocysteine deaminase activity
IOD66_06995	COG1560	Kdo2-lipid A biosynthetic process
IOD66_07010	COG4658	electron transport chain
IOD66_07020	COG4656	Part of a membrane complex involved in electron transport
IOD66_07025	COG2878	Part of a membrane complex involved in electron transport
IOD66_07030	COG4657	Part of a membrane complex involved in electron transport
IOD66_07045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOD66_07050	COG2974	May be involved in recombination
IOD66_07055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOD66_07060	COG2814	Major facilitator Superfamily
IOD66_07065	COG0482	sulfurtransferase activity
IOD66_07070	COG2991	Protein conserved in bacteria
IOD66_07075	COG1477	protein flavinylation
IOD66_07080	COG2871	sodium ion transport
IOD66_07085	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_07090	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_07095	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_07100	COG1805	sodium ion transport
IOD66_07105	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IOD66_07110	COG0316	Belongs to the HesB IscA family
IOD66_07110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IOD66_07115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOD66_07125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOD66_07130	COG1611	Belongs to the LOG family
IOD66_07135	COG3593	DNA synthesis involved in DNA repair
IOD66_07140	COG1254	Belongs to the acylphosphatase family
IOD66_07145	COG1929	Belongs to the glycerate kinase type-1 family
IOD66_07150	COG2610	gluconate transmembrane transporter activity
IOD66_07155	COG3835	regulator
IOD66_07160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IOD66_07165	COG0066	3-isopropylmalate dehydratase activity
IOD66_07170	COG5413	integral membrane protein
IOD66_07175	COG0504	CTP synthase activity
IOD66_07180	COG0252	asparaginase activity
IOD66_07190	COG0583	DNA-binding transcription factor activity
IOD66_07195	COG1011	Hydrolase
IOD66_07200	COG0583	DNA-binding transcription factor activity
IOD66_07205	COG1162	GTPase activity
IOD66_07210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOD66_07215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD66_07220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOD66_07225	COG0537	adenosine 5'-monophosphoramidase activity
IOD66_07240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOD66_07245	COG3108	Peptidase M15
IOD66_07250	COG2989	Protein conserved in bacteria
IOD66_07255	COG0793	Belongs to the peptidase S41A family
IOD66_07260	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IOD66_07265	COG1278	Cold shock
IOD66_07270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOD66_07290	COG3068	Protein conserved in bacteria
IOD66_07295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IOD66_07305	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IOD66_07315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOD66_07320	COG1414	Transcriptional regulator
IOD66_07325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOD66_07350	COG3301	Polysulphide reductase, NrfD
IOD66_07355	COG0437	4 iron, 4 sulfur cluster binding
IOD66_07360	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IOD66_07375	COG3978	acetolactate synthase activity
IOD66_07380	COG0129	dihydroxy-acid dehydratase activity
IOD66_07400	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IOD66_07410	COG0006	proline dipeptidase activity
IOD66_07415	COG3030	protein affecting phage T7 exclusion by the F plasmid
IOD66_07435	COG3753	Protein conserved in bacteria
IOD66_07440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IOD66_07445	COG0492	ferredoxin-NADP+ reductase activity
IOD66_07450	COG2376	Dihydroxyacetone kinase
IOD66_07455	COG1461	Dihydroxyacetone kinase
IOD66_07460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOD66_07460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_07460	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IOD66_07465	COG3118	belongs to the thioredoxin family
IOD66_07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD66_07475	COG0811	peptide transport
IOD66_07480	COG0848	biopolymer transport protein
IOD66_07485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IOD66_07490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IOD66_07495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOD66_07500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IOD66_07505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOD66_07510	COG0251	oxidation-reduction process
IOD66_07525	COG4608	Belongs to the ABC transporter superfamily
IOD66_07535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOD66_07540	COG0601	transmembrane transport
IOD66_07545	COG0747	negative chemotaxis
IOD66_07550	COG0747	negative chemotaxis
IOD66_07590	COG3630	sodium ion export across plasma membrane
IOD66_07600	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IOD66_07605	COG2824	Alkylphosphonate utilization operon protein PhnA
IOD66_07610	COG1858	cytochrome C peroxidase
IOD66_07615	COG1872	DUF167
IOD66_07620	COG0762	integral membrane protein
IOD66_07625	COG3171	Protein conserved in bacteria
IOD66_07630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOD66_07635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOD66_07640	COG0416	fatty acid biosynthetic process
IOD66_07645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IOD66_07650	COG1399	metal-binding, possibly nucleic acid-binding protein
IOD66_07655	COG4137	Cytochrome C assembly protein
IOD66_07660	COG4536	flavin adenine dinucleotide binding
IOD66_07665	COG0733	neurotransmitter:sodium symporter activity
IOD66_07675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD66_07675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_07680	COG3715	PTS system
IOD66_07685	COG3716	PTS system mannose fructose sorbose family IID component
IOD66_07710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOD66_07715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IOD66_07720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOD66_07740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IOD66_07750	COG1720	tRNA m6t6A37 methyltransferase activity
IOD66_07755	COG4804	nuclease activity
IOD66_07760	COG1575	Belongs to the MenA family. Type 1 subfamily
IOD66_07765	COG0316	Belongs to the HesB IscA family
IOD66_07785	COG1442	glycosyl transferase family 8
IOD66_07785	COG1216	Glycosyl transferase, family 2
IOD66_07810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOD66_07815	COG1088	dTDP-glucose 4,6-dehydratase activity
IOD66_07820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IOD66_07830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD66_07835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOD66_07845	COG0557	exoribonuclease II activity
IOD66_07850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD66_07855	COG1309	transcriptional regulator
IOD66_07860	COG0583	DNA-binding transcription factor activity
IOD66_07865	COG0678	peroxiredoxin activity
IOD66_07865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOD66_07875	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IOD66_07880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOD66_07895	COG1840	ABC-type Fe3 transport system, periplasmic component
IOD66_07925	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IOD66_07930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOD66_07935	COG1755	Isoprenylcysteine carboxyl methyltransferase
IOD66_07945	COG1530	ribonuclease E activity
IOD66_07960	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOD66_07965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD66_07975	COG0243	molybdopterin cofactor binding
IOD66_07980	COG0437	4 iron, 4 sulfur cluster binding
IOD66_07985	COG0348	domain, Protein
IOD66_07990	COG3043	anaerobic respiration
IOD66_07995	COG3005	denitrification pathway
IOD66_08005	COG2050	protein possibly involved in aromatic compounds catabolism
IOD66_08010	COG0247	lactate metabolic process
IOD66_08010	COG0277	FAD linked oxidase domain protein
IOD66_08015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOD66_08015	COG2885	chlorophyll binding
IOD66_08020	COG1879	ABC-type sugar transport system periplasmic component
IOD66_08025	COG1129	ABC transporter
IOD66_08030	COG4211	Belongs to the binding-protein-dependent transport system permease family
IOD66_08050	COG0579	oxidoreductase
IOD66_08055	COG1022	Amp-dependent synthetase and ligase
IOD66_08060	COG4989	oxidoreductase activity
IOD66_08065	COG3691	Protein conserved in bacteria
IOD66_08070	COG0814	amino acid
IOD66_08080	COG2918	glutathione biosynthetic process
IOD66_08080	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOD66_08085	COG0688	phosphatidylethanolamine metabolic process
IOD66_08090	COG1555	photosystem II stabilization
IOD66_08095	COG3266	domain, Protein
IOD66_08095	COG3061	Opacity-associated protein A
IOD66_08105	COG0859	PFAM glycosyl transferase family 9
IOD66_08110	COG0859	PFAM glycosyl transferase family 9
IOD66_08115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IOD66_08120	COG0049	tRNA binding
IOD66_08125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOD66_08130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD66_08145	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IOD66_08155	COG0825	malonyl-CoA metabolic process
IOD66_08165	COG0204	Acyl-transferase
IOD66_08170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IOD66_08175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IOD66_08180	COG2848	UPF0210 protein
IOD66_08195	COG0783	Belongs to the Dps family
IOD66_08210	COG1289	transmembrane transporter activity
IOD66_08215	COG1803	Methylglyoxal synthase
IOD66_08220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOD66_08230	COG0525	valine-tRNA ligase activity
IOD66_08245	COG2153	protein acetylation
IOD66_08250	COG2927	DNA polymerase III (CHI subunit)
IOD66_08255	COG1652	LysM domain
IOD66_08260	COG0544	peptidyl-prolyl cis-trans isomerase activity
IOD66_08265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOD66_08270	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IOD66_08275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOD66_08280	COG1045	serine acetyltransferase
IOD66_08285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOD66_08310	COG1072	(Pantothenic acid kinase))
IOD66_08315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IOD66_08330	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOD66_08340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IOD66_08345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IOD66_08350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IOD66_08365	COG0625	glutathione transferase activity
IOD66_08370	COG0019	diaminopimelate decarboxylase activity
IOD66_08380	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IOD66_08385	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IOD66_08390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOD66_08395	COG1053	succinate dehydrogenase
IOD66_08400	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IOD66_08405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IOD66_08410	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOD66_08415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOD66_08425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IOD66_08430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IOD66_08435	COG2264	protein methyltransferase activity
IOD66_08455	COG0037	tRNA processing
IOD66_08465	COG4974	Belongs to the 'phage' integrase family
IOD66_08510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOD66_08520	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IOD66_08525	COG1522	sequence-specific DNA binding
IOD66_08530	COG2502	aspartate--ammonia ligase
IOD66_08545	COG3311	Transcriptional regulator
IOD66_08575	COG3210	domain, Protein
IOD66_08575	COG3210	domain, Protein
IOD66_08580	COG2831	hemolysin activation secretion protein
IOD66_08610	COG0640	Transcriptional regulator
IOD66_08625	COG0786	glutamate:sodium symporter activity
IOD66_08650	COG0582	viral genome integration into host DNA
IOD66_08665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOD66_08675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IOD66_08680	COG1595	DNA-templated transcription, initiation
IOD66_08685	COG0442	prolyl-tRNA aminoacylation
IOD66_08700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOD66_08710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOD66_08715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IOD66_08720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOD66_08725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOD66_08730	COG0254	rRNA binding
IOD66_08735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOD66_08740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOD66_08760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOD66_08765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IOD66_08770	COG0470	DNA polymerase III
IOD66_08780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOD66_08795	COG0084	hydrolase, TatD family'
IOD66_08805	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOD66_08810	COG1215	transferase activity, transferring glycosyl groups
IOD66_08830	COG0751	glycine-tRNA ligase activity
IOD66_08840	COG2852	Protein conserved in bacteria
IOD66_08845	COG0752	glycyl-tRNA synthetase alpha subunit
IOD66_08885	COG4139	cobalamin transport
IOD66_08890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD66_08895	COG2850	peptidyl-arginine hydroxylation
IOD66_08900	COG0335	large ribosomal subunit rRNA binding
IOD66_08905	COG0336	Belongs to the RNA methyltransferase TrmD family
IOD66_08910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOD66_08915	COG0228	four-way junction DNA binding
IOD66_08925	COG0202	RNA polymerase activity
IOD66_08930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IOD66_08935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IOD66_08940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IOD66_08945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOD66_08950	COG0201	protein transport
IOD66_08955	COG0200	Binds to the 23S rRNA
IOD66_08960	COG1841	ribosomal large subunit assembly
IOD66_08965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IOD66_08970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IOD66_08975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IOD66_08980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IOD66_08985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOD66_08990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IOD66_08995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IOD66_09005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IOD66_09010	COG0255	Belongs to the universal ribosomal protein uL29 family
IOD66_09015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IOD66_09020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IOD66_09025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IOD66_09030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOD66_09035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IOD66_09040	COG0089	rRNA binding
IOD66_09045	COG0088	Forms part of the polypeptide exit tunnel
IOD66_09050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IOD66_09055	COG0051	transcription antitermination factor activity, RNA binding
IOD66_09070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IOD66_09075	COG0363	glucosamine-6-phosphate deaminase activity
IOD66_09080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOD66_09090	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IOD66_09100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IOD66_09105	COG2267	carboxylic ester hydrolase activity
IOD66_09115	COG0606	chelatase, subunit chli
IOD66_09120	COG3657	addiction module killer protein
IOD66_09125	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOD66_09130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOD66_09135	COG0737	Belongs to the 5'-nucleotidase family
IOD66_09140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOD66_09170	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IOD66_09175	COG1194	a g-specific adenine glycosylase
IOD66_09180	COG0346	lactoylglutathione lyase activity
IOD66_09185	COG1489	DNA binding
IOD66_09190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IOD66_09195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IOD66_09215	COG1487	ribonuclease activity
IOD66_09235	COG0085	RNA polymerase activity
IOD66_09280	COG0222	ribosome binding
IOD66_09285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IOD66_09290	COG0081	regulation of translation
IOD66_09295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IOD66_09305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOD66_09320	COG1297	OPT oligopeptide transporter protein
IOD66_09325	COG0758	DNA mediated transformation
IOD66_09335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOD66_09360	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD66_09365	COG0235	Class ii aldolase
IOD66_09370	COG3623	hexulose-6-phosphate isomerase
IOD66_09395	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IOD66_09415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD66_09420	COG1126	abc transporter atp-binding protein
IOD66_09430	COG0765	amino acid transport
IOD66_09435	COG3477	response to acidic pH
IOD66_09440	COG1454	alcohol dehydrogenase
IOD66_09445	COG0738	Major facilitator superfamily
IOD66_09450	COG0235	Class ii aldolase
IOD66_09455	COG4154	Belongs to the RbsD FucU family
IOD66_09460	COG1070	Carbohydrate kinase
IOD66_09465	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
IOD66_09470	COG1349	DNA-binding transcription factor activity
IOD66_09495	COG2221	Nitrite and sulphite reductase 4Fe-4S
IOD66_09495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOD66_09500	COG3381	protein complex oligomerization
IOD66_09505	COG3302	dmso reductase anchor subunit
IOD66_09510	COG0437	4 iron, 4 sulfur cluster binding
IOD66_09515	COG0243	molybdopterin cofactor binding
IOD66_09520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD66_09525	COG1879	ABC-type sugar transport system periplasmic component
IOD66_09530	COG1172	Belongs to the binding-protein-dependent transport system permease family
IOD66_09540	COG1869	D-ribose catabolic process
IOD66_09550	COG1609	Transcriptional regulator
IOD66_09555	COG3265	gluconokinase activity
IOD66_09560	COG2610	gluconate transmembrane transporter activity
IOD66_09565	COG2801	Transposase and inactivated derivatives
IOD66_09570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IOD66_09570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOD66_09575	COG3715	PTS system
IOD66_09580	COG3716	PTS system mannose fructose sorbose family IID component
IOD66_09595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOD66_09600	COG0561	phosphatase activity
IOD66_09605	COG0445	tRNA wobble uridine modification
IOD66_09610	COG0357	Ribosomal RNA small subunit methyltransferase G
IOD66_09630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IOD66_09635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOD66_09640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IOD66_09645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IOD66_09650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IOD66_09655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IOD66_09680	COG2168	tRNA wobble position uridine thiolation
IOD66_09690	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOD66_09695	COG2964	Protein conserved in bacteria
IOD66_09700	COG0545	Peptidyl-prolyl cis-trans isomerase
IOD66_09705	COG2900	Belongs to the SlyX family
IOD66_09710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_09715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOD66_09720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOD66_09725	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
IOD66_09740	COG1349	DNA-binding transcription factor activity
IOD66_09745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOD66_09755	COG0246	Mannitol dehydrogenase
IOD66_09760	COG3722	fumarate hydratase activity
IOD66_09765	COG0471	metal ion transport
IOD66_09765	COG0490	domain, Protein
IOD66_09775	COG0583	DNA-binding transcription factor activity
IOD66_09780	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
IOD66_09785	COG0310	cobalt ion transport
IOD66_09790	COG0310	cobalt ion transport
IOD66_09795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IOD66_09800	COG1122	ATPase activity
IOD66_09810	COG0831	urea catabolic process
IOD66_09815	COG0832	Belongs to the urease beta subunit family
IOD66_09840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IOD66_09860	COG3691	Protein conserved in bacteria
IOD66_09870	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IOD66_09875	COG3681	Belongs to the UPF0597 family
IOD66_09880	COG0765	amino acid transport
IOD66_09885	COG1126	abc transporter atp-binding protein
IOD66_09895	COG0799	negative regulation of ribosome biogenesis
IOD66_09900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IOD66_09905	COG0768	penicillin binding
IOD66_09910	COG0772	Belongs to the SEDS family
IOD66_09915	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD66_09920	COG1686	Belongs to the peptidase S11 family
IOD66_09925	COG2921	Belongs to the UPF0250 family
IOD66_09930	COG0321	lipoyl(octanoyl) transferase activity
IOD66_09935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOD66_09940	COG1970	mechanosensitive ion channel activity
IOD66_09945	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IOD66_09950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IOD66_09955	COG1739	Uncharacterized protein family UPF0029
IOD66_09965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IOD66_09970	COG1119	ATPase activity
IOD66_10015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IOD66_10020	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOD66_10020	COG0517	IMP dehydrogenase activity
IOD66_10030	COG3545	Serine hydrolase
IOD66_10045	COG2431	L-lysine efflux transmembrane transporter activity
IOD66_10070	COG1629	transport
IOD66_10070	COG4771	TonB-dependent receptor
IOD66_10090	COG0716	FMN binding
IOD66_10100	COG1921	L-seryl-tRNASec selenium transferase activity
IOD66_10105	COG3276	selenocysteine insertion sequence binding
IOD66_10110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IOD66_10115	COG0569	domain protein
IOD66_10120	COG0268	Binds directly to 16S ribosomal RNA
IOD66_10125	COG0728	peptidoglycan biosynthetic process
IOD66_10135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IOD66_10145	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IOD66_10150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IOD66_10155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOD66_10165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOD66_10170	COG2244	polysaccharide biosynthetic process
IOD66_10175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOD66_10180	COG1151	hydroxylamine reductase activity
IOD66_10195	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IOD66_10235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOD66_10260	COG4208	sulfate ABC transporter
IOD66_10265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOD66_10270	COG1304	FMN binding
IOD66_10280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IOD66_10290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOD66_10295	COG2995	paraquat-inducible protein a
IOD66_10300	COG1305	Transglutaminase-like
IOD66_10310	COG2608	mercury ion transmembrane transporter activity
IOD66_10320	COG0583	DNA-binding transcription factor activity
IOD66_10325	COG2171	N-acyltransferase activity
IOD66_10330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IOD66_10340	COG0511	ligase activity, forming carbon-carbon bonds
IOD66_10345	COG0439	Biotin carboxylase
IOD66_10355	COG3084	Protein conserved in bacteria
IOD66_10360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOD66_10370	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD66_10370	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOD66_10375	COG0742	ribosomal rna small subunit methyltransferase
IOD66_10380	COG1876	peptidase activity
IOD66_10385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOD66_10390	COG1393	Belongs to the ArsC family
IOD66_10400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOD66_10405	COG0564	pseudouridine synthase activity
IOD66_10415	COG0668	transmembrane transport
IOD66_10420	COG0439	Biotin carboxylase
IOD66_10430	COG1025	Belongs to the peptidase M16 family
IOD66_10435	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IOD66_10460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOD66_10470	COG3120	sequence-specific DNA binding
IOD66_10475	COG0180	Tryptophanyl-tRNA synthetase
IOD66_10490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IOD66_10495	COG0730	response to heat
IOD66_10510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOD66_10515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IOD66_10520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOD66_10525	COG2116	formate transmembrane transporter activity
IOD66_10540	COG0484	heat shock protein binding
IOD66_10545	COG0443	Heat shock 70 kDa protein
IOD66_10550	COG1070	Carbohydrate kinase
IOD66_10555	COG2115	Belongs to the xylose isomerase family
IOD66_10560	COG4213	ABC transporter substrate-binding protein
IOD66_10565	COG1129	ABC transporter
IOD66_10570	COG4214	carbohydrate transport
IOD66_10575	COG1609	Transcriptional regulator
IOD66_10575	COG2207	Transcriptional regulator
IOD66_10580	COG3590	peptidase
IOD66_10590	COG4145	pantothenate transmembrane transporter activity
IOD66_10595	COG3924	membrane
IOD66_10600	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IOD66_10605	COG2853	Lipoprotein
IOD66_10610	COG0676	glucose-6-phosphate 1-epimerase activity
IOD66_10625	COG0726	polysaccharide deacetylase
IOD66_10625	COG1649	PFAM Uncharacterised BCR, COG1649
IOD66_10640	COG0149	triose-phosphate isomerase activity
IOD66_10650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IOD66_10655	COG1238	metal cluster binding
IOD66_10670	COG1388	LysM domain
IOD66_10670	COG4942	peptidase
IOD66_10675	COG2818	Glycosylase
IOD66_10685	COG0700	Nucleoside recognition
IOD66_10695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IOD66_10700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IOD66_10705	COG0594	ribonuclease P activity
IOD66_10710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOD66_10715	COG0174	glutamine synthetase
IOD66_10720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOD66_10725	COG0494	nUDIX hydrolase
IOD66_10745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOD66_10755	COG1490	D-aminoacyl-tRNA deacylase activity
IOD66_10760	COG1295	ribonuclease BN
IOD66_10765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IOD66_10770	COG1629	transport
IOD66_10770	COG4771	TonB-dependent receptor
IOD66_10805	COG1064	alcohol dehydrogenase
IOD66_10815	COG1923	regulation of RNA biosynthetic process
IOD66_10820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOD66_10830	COG1694	Mazg nucleotide pyrophosphohydrolase
IOD66_10845	COG1309	transcriptional regulator
IOD66_10850	COG0756	dUTP diphosphatase activity
IOD66_10855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOD66_10860	COG2003	Belongs to the UPF0758 family
IOD66_10865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOD66_10870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOD66_10880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOD66_10885	COG0076	glutamate decarboxylase activity
IOD66_10890	COG0425	Belongs to the sulfur carrier protein TusA family
IOD66_10895	COG2391	methyltransferase activity
IOD66_10900	COG3085	chromosome segregation
IOD66_10905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOD66_10930	COG0598	Magnesium transport protein CorA
IOD66_10935	COG2226	methyltransferase
IOD66_10945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOD66_10950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD66_10955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOD66_10960	COG0805	protein transport
IOD66_10975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IOD66_10980	COG1114	Component of the transport system for branched-chain amino acids
IOD66_10985	COG1028	Short-chain dehydrogenase reductase Sdr
IOD66_10990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOD66_10995	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOD66_11000	COG0142	geranyltranstransferase activity
IOD66_11010	COG0431	NADPH-dependent FMN reductase
IOD66_11015	COG2259	Doxx family
IOD66_11020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IOD66_11025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IOD66_11030	COG0697	spore germination
IOD66_11035	COG4783	chaperone-mediated protein folding
IOD66_11045	COG1040	competence protein
IOD66_11050	COG2813	Specifically methylates the guanine in position
IOD66_11060	COG0456	acetyltransferase
IOD66_11065	COG0513	Belongs to the DEAD box helicase family
IOD66_11070	COG0259	pyridoxamine-phosphate oxidase activity
IOD66_11075	COG0747	negative chemotaxis
IOD66_11085	COG1584	GPR1 FUN34 yaaH family protein
IOD66_11090	COG1120	ATPase activity
IOD66_11095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOD66_11105	COG4774	siderophore transport
IOD66_11115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IOD66_11120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOD66_11125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IOD66_11130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOD66_11140	COG0131	Imidazoleglycerol-phosphate dehydratase
IOD66_11140	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOD66_11155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOD66_11170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOD66_11170	COG0140	phosphoribosyl-ATP diphosphatase activity
IOD66_11175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IOD66_11180	COG0024	Methionine aminopeptidase
IOD66_11195	COG1621	beta-fructofuranosidase activity
IOD66_11200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOD66_11210	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD66_11215	COG1136	(ABC) transporter
IOD66_11220	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOD66_11225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOD66_11255	COG2897	thiosulfate sulfurtransferase activity
IOD66_11260	COG2391	methyltransferase activity