locus-tag	class	description
CYK57_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYK57_00002	COG0592	DNA-directed DNA polymerase activity
CYK57_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYK57_00005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYK57_00007	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYK57_00008	COG0616	signal peptide processing
CYK57_00010	COG2001	Belongs to the MraZ family
CYK57_00011	COG0275	rRNA processing
CYK57_00012	COG3116	cell division
CYK57_00013	COG0768	penicillin binding
CYK57_00014	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYK57_00015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CYK57_00016	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYK57_00017	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYK57_00018	COG0772	Belongs to the SEDS family
CYK57_00019	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYK57_00020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYK57_00021	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYK57_00023	COG0849	cell division
CYK57_00024	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYK57_00025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CYK57_00026	COG0497	DNA recombination
CYK57_00027	COG4172	Belongs to the ABC transporter superfamily
CYK57_00028	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYK57_00029	COG0601	transmembrane transport
CYK57_00031	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CYK57_00041	COG1196	nuclear chromosome segregation
CYK57_00045	COG2003	Belongs to the UPF0758 family
CYK57_00050	COG0714	Associated with various cellular activities
CYK57_00055	COG2356	endonuclease I
CYK57_00063	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYK57_00084	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CYK57_00088	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYK57_00099	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYK57_00114	COG0193	aminoacyl-tRNA hydrolase activity
CYK57_00115	COG0012	GTP binding
CYK57_00116	COG2020	methyltransferase activity
CYK57_00118	COG3133	Outer membrane lipoprotein
CYK57_00119	COG3102	Protein conserved in bacteria
CYK57_00120	COG0018	arginyl-trna synthetase
CYK57_00121	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYK57_00123	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYK57_00124	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYK57_00125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYK57_00126	COG0196	riboflavin kinase activity
CYK57_00127	COG3172	ATPase kinase involved in NAD metabolism
CYK57_00128	COG2129	metallophosphoesterase
CYK57_00129	COG0745	RESPONSE REGULATOR receiver
CYK57_00132	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CYK57_00133	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYK57_00134	COG1217	gtp-binding protein TYPA
CYK57_00135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYK57_00136	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYK57_00137	COG1561	YicC-like family, N-terminal region
CYK57_00138	COG0354	folic acid binding
CYK57_00139	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CYK57_00140	COG2197	response regulator
CYK57_00142	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CYK57_00142	COG0116	Belongs to the methyltransferase superfamily
CYK57_00143	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYK57_00151	COG0747	negative chemotaxis
CYK57_00152	COG0747	negative chemotaxis
CYK57_00153	COG0601	transmembrane transport
CYK57_00154	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYK57_00155	COG0444	Belongs to the ABC transporter superfamily
CYK57_00156	COG4608	Belongs to the ABC transporter superfamily
CYK57_00159	COG0251	oxidation-reduction process
CYK57_00160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYK57_00161	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CYK57_00162	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYK57_00163	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYK57_00164	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CYK57_00165	COG0848	biopolymer transport protein
CYK57_00166	COG0811	peptide transport
CYK57_00167	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYK57_00168	COG3118	belongs to the thioredoxin family
CYK57_00169	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYK57_00169	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYK57_00169	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CYK57_00170	COG1461	Dihydroxyacetone kinase
CYK57_00171	COG2376	Dihydroxyacetone kinase
CYK57_00172	COG0492	ferredoxin-NADP+ reductase activity
CYK57_00173	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CYK57_00174	COG3753	Protein conserved in bacteria
CYK57_00178	COG3030	protein affecting phage T7 exclusion by the F plasmid
CYK57_00179	COG0006	proline dipeptidase activity
CYK57_00181	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CYK57_00185	COG0129	dihydroxy-acid dehydratase activity
CYK57_00186	COG3978	acetolactate synthase activity
CYK57_00190	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CYK57_00191	COG0437	4 iron, 4 sulfur cluster binding
CYK57_00192	COG3301	Polysulphide reductase, NrfD
CYK57_00194	COG5295	Hep Hag repeat protein
CYK57_00194	COG5295	Hep Hag repeat protein
CYK57_00194	COG5295	Hep Hag repeat protein
CYK57_00194	COG5295	Hep Hag repeat protein
CYK57_00198	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYK57_00199	COG1414	Transcriptional regulator
CYK57_00200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CYK57_00201	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CYK57_00203	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYK57_00204	COG3068	Protein conserved in bacteria
CYK57_00208	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYK57_00209	COG1278	Cold shock
CYK57_00210	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CYK57_00211	COG0793	Belongs to the peptidase S41A family
CYK57_00212	COG2989	Protein conserved in bacteria
CYK57_00213	COG3108	Peptidase M15
CYK57_00214	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYK57_00217	COG0537	adenosine 5'-monophosphoramidase activity
CYK57_00218	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYK57_00219	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYK57_00220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYK57_00221	COG1162	GTPase activity
CYK57_00222	COG0583	DNA-binding transcription factor activity
CYK57_00223	COG1011	Hydrolase
CYK57_00224	COG0583	DNA-binding transcription factor activity
CYK57_00226	COG0252	asparaginase activity
CYK57_00227	COG0504	CTP synthase activity
CYK57_00228	COG5413	integral membrane protein
CYK57_00229	COG0066	3-isopropylmalate dehydratase activity
CYK57_00230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYK57_00231	COG3835	regulator
CYK57_00232	COG2610	gluconate transmembrane transporter activity
CYK57_00233	COG1929	Belongs to the glycerate kinase type-1 family
CYK57_00234	COG1254	Belongs to the acylphosphatase family
CYK57_00235	COG3593	DNA synthesis involved in DNA repair
CYK57_00236	COG1611	Belongs to the LOG family
CYK57_00237	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYK57_00239	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYK57_00240	COG0316	Belongs to the HesB IscA family
CYK57_00240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CYK57_00241	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CYK57_00242	COG1805	sodium ion transport
CYK57_00243	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CYK57_00244	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CYK57_00245	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CYK57_00246	COG2871	sodium ion transport
CYK57_00247	COG1477	protein flavinylation
CYK57_00248	COG2991	Protein conserved in bacteria
CYK57_00249	COG0482	sulfurtransferase activity
CYK57_00250	COG2814	Major facilitator Superfamily
CYK57_00251	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CYK57_00252	COG2974	May be involved in recombination
CYK57_00253	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYK57_00256	COG4657	Part of a membrane complex involved in electron transport
CYK57_00257	COG2878	Part of a membrane complex involved in electron transport
CYK57_00258	COG4656	Part of a membrane complex involved in electron transport
CYK57_00260	COG4658	electron transport chain
CYK57_00263	COG1560	Kdo2-lipid A biosynthetic process
CYK57_00264	COG0402	S-adenosylhomocysteine deaminase activity
CYK57_00265	COG4143	(ABC) transporter
CYK57_00266	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CYK57_00267	COG0617	tRNA 3'-terminal CCA addition
CYK57_00268	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYK57_00270	COG2911	Protein conserved in bacteria
CYK57_00272	COG0346	lactoylglutathione lyase activity
CYK57_00273	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CYK57_00275	COG0287	Prephenate dehydrogenase
CYK57_00275	COG1605	Chorismate mutase
CYK57_00276	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYK57_00277	COG0859	PFAM glycosyl transferase family 9
CYK57_00278	COG0469	pyruvate kinase activity
CYK57_00279	COG2062	phosphohistidine phosphatase, SixA
CYK57_00280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYK57_00281	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CYK57_00282	COG0733	neurotransmitter:sodium symporter activity
CYK57_00283	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CYK57_00284	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYK57_00285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYK57_00287	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYK57_00288	COG4972	Pilus assembly protein
CYK57_00292	COG4796	Type ii and iii secretion system protein
CYK57_00293	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYK57_00294	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CYK57_00295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CYK57_00296	COG1280	lysine exporter protein (LysE YggA)
CYK57_00297	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYK57_00299	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYK57_00300	COG2801	Transposase and inactivated derivatives
CYK57_00301	COG2801	Transposase and inactivated derivatives
CYK57_00302	COG2963	transposase activity
CYK57_00303	COG2963	transposase activity
CYK57_00304	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYK57_00305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYK57_00308	COG1518	maintenance of DNA repeat elements
CYK57_00314	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYK57_00318	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYK57_00319	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYK57_00320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYK57_00323	COG1253	flavin adenine dinucleotide binding
CYK57_00324	COG0564	pseudouridine synthase activity
CYK57_00325	COG0588	phosphoglycerate mutase activity
CYK57_00326	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYK57_00327	COG1678	Uncharacterized ACR, COG1678
CYK57_00328	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CYK57_00330	COG0271	Belongs to the BolA IbaG family
CYK57_00335	COG0653	protein targeting
CYK57_00337	COG0494	nUDIX hydrolase
CYK57_00338	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYK57_00339	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYK57_00340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYK57_00342	COG1629	transport
CYK57_00342	COG4771	TonB-dependent receptor
CYK57_00344	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CYK57_00346	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYK57_00347	COG0083	homoserine kinase activity
CYK57_00348	COG0527	aspartate kinase activity
CYK57_00348	COG0460	homoserine dehydrogenase
CYK57_00349	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYK57_00350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYK57_00351	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CYK57_00356	COG2195	Cleaves the N-terminal amino acid of tripeptides
CYK57_00357	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CYK57_00358	COG0194	GDP metabolic process
CYK57_00359	COG1538	Outer membrane efflux protein
CYK57_00360	COG2914	Belongs to the UPF0125 (RnfH) family
CYK57_00361	COG2867	negative regulation of translational initiation
CYK57_00362	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CYK57_00363	COG4149	molybdate abc transporter
CYK57_00364	COG0725	ABC transporter, periplasmic molybdate-binding protein
CYK57_00365	COG0842	Transport permease protein
CYK57_00366	COG1131	(ABC) transporter
CYK57_00367	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYK57_00368	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CYK57_00370	COG0251	oxidation-reduction process
CYK57_00371	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CYK57_00372	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CYK57_00373	COG1121	(ABC) transporter
CYK57_00375	COG2920	part of a sulfur-relay system
CYK57_00376	COG0670	Belongs to the BI1 family
CYK57_00377	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYK57_00379	COG0322	excinuclease ABC activity
CYK57_00381	COG0084	hydrolase, TatD family'
CYK57_00382	COG0210	DNA helicase
CYK57_00383	COG3842	ATPase activity
CYK57_00384	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYK57_00385	COG1177	transmembrane transport
CYK57_00386	COG0632	four-way junction helicase activity
CYK57_00387	COG2255	four-way junction helicase activity
CYK57_00388	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYK57_00389	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYK57_00397	COG0488	(ABC) transporter
CYK57_00398	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CYK57_00400	COG1271	oxidase subunit
CYK57_00401	COG1294	oxidase, subunit
CYK57_00402	COG0824	Thioesterase
CYK57_00403	COG0811	peptide transport
CYK57_00404	COG0848	biopolymer transport protein
CYK57_00405	COG3064	Membrane
CYK57_00406	COG0823	Involved in the tonB-independent uptake of proteins
CYK57_00409	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CYK57_00410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYK57_00412	COG0488	(ABC) transporter
CYK57_00414	COG0303	'Molybdopterin
CYK57_00415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYK57_00417	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYK57_00418	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CYK57_00420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYK57_00421	COG0564	pseudouridine synthase activity
CYK57_00422	COG3023	N-Acetylmuramoyl-L-alanine amidase
CYK57_00423	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CYK57_00424	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYK57_00425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYK57_00426	COG0626	cystathionine gamma-synthase activity
CYK57_00427	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CYK57_00430	COG1702	phosphate starvation-inducible protein PhoH
CYK57_00432	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CYK57_00434	COG0709	Synthesizes selenophosphate from selenide and ATP
CYK57_00436	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYK57_00440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYK57_00441	COG1660	Displays ATPase and GTPase activities
CYK57_00442	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYK57_00443	COG1137	ATPase activity
CYK57_00444	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CYK57_00446	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CYK57_00447	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CYK57_00449	COG1704	LemA family
CYK57_00450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CYK57_00450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CYK57_00450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CYK57_00451	COG1105	Belongs to the carbohydrate kinase PfkB family
CYK57_00452	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYK57_00452	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYK57_00453	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYK57_00454	COG1523	belongs to the glycosyl hydrolase 13 family
CYK57_00455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYK57_00456	COG0297	glycogen (starch) synthase activity
CYK57_00457	COG0058	SHG alpha-glucan phosphorylase activity
CYK57_00458	COG0105	UTP biosynthetic process
CYK57_00459	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYK57_00459	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYK57_00462	COG1187	pseudouridine synthase activity
CYK57_00463	COG2814	Major facilitator Superfamily
CYK57_00465	COG3381	protein complex oligomerization
CYK57_00466	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CYK57_00467	COG0791	NLP P60 protein
CYK57_00468	COG2932	Transcriptional regulator
CYK57_00469	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CYK57_00470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CYK57_00471	COG2990	Protein conserved in bacteria
CYK57_00473	COG1643	Atp-dependent helicase
CYK57_00475	COG2707	UPF0756 membrane protein
CYK57_00476	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYK57_00477	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CYK57_00478	COG0534	Mate efflux family protein
CYK57_00479	COG1074	ATP-dependent DNA helicase activity
CYK57_00480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYK57_00481	COG4535	Mg2 and Co2 transporter CorC
CYK57_00484	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CYK57_00485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CYK57_00486	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYK57_00487	COG2271	Major facilitator Superfamily
CYK57_00488	COG0584	glycerophosphoryl diester phosphodiesterase
CYK57_00489	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CYK57_00490	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CYK57_00491	COG0247	lactate metabolic process
CYK57_00498	COG0517	IMP dehydrogenase activity
CYK57_00498	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CYK57_00500	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CYK57_00501	COG0385	Bile acid
CYK57_00502	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYK57_00503	COG0561	phosphatase activity
CYK57_00505	COG1595	DNA-templated transcription, initiation
CYK57_00506	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CYK57_00508	COG0318	PFAM AMP-dependent synthetase and ligase
CYK57_00509	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYK57_00510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYK57_00511	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYK57_00512	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CYK57_00513	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CYK57_00513	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CYK57_00514	COG1160	GTP binding
CYK57_00516	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CYK57_00517	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYK57_00518	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYK57_00519	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYK57_00520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYK57_00521	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYK57_00524	COG0750	zinc metalloprotease
CYK57_00525	COG0575	Belongs to the CDS family
CYK57_00526	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYK57_00527	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYK57_00529	COG0671	phosphoesterase, PA-phosphatase related
CYK57_00530	COG1534	Rna-binding protein
CYK57_00531	COG0463	Glycosyl transferase, family 2
CYK57_00532	COG1686	Belongs to the peptidase S11 family
CYK57_00533	COG0859	PFAM glycosyl transferase family 9
CYK57_00535	COG0328	RNA-DNA hybrid ribonuclease activity
CYK57_00536	COG1286	toxin biosynthetic process
CYK57_00537	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYK57_00539	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYK57_00540	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYK57_00541	COG3081	Nucleoid-associated protein
CYK57_00542	COG0251	oxidation-reduction process
CYK57_00543	COG1496	oxidoreductase activity
CYK57_00545	COG5645	(Lipo)protein
CYK57_00548	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CYK57_00551	COG1792	Involved in formation and maintenance of cell shape
CYK57_00552	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CYK57_00553	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CYK57_00554	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYK57_00555	COG0121	glutamine amidotransferase
CYK57_00556	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CYK57_00557	COG2949	membrane
CYK57_00560	COG1556	Lactate utilization protein
CYK57_00561	COG1139	Iron-sulfur cluster binding protein
CYK57_00562	COG0247	lactate metabolic process
CYK57_00563	COG1620	l-lactate permease
CYK57_00564	COG2916	Histone family protein nucleoid-structuring protein H-NS
CYK57_00565	COG1757	Na H antiporter
CYK57_00566	COG1879	ABC-type sugar transport system periplasmic component
CYK57_00567	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CYK57_00568	COG0045	succinate-CoA ligase (ADP-forming) activity
CYK57_00569	COG2990	Protein conserved in bacteria
CYK57_00570	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYK57_00571	COG0567	Dehydrogenase, E1 component
CYK57_00572	COG1121	(ABC) transporter
CYK57_00573	COG0739	heme binding
CYK57_00574	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYK57_00576	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYK57_00578	COG0561	phosphatase activity
CYK57_00579	COG3850	Histidine kinase
CYK57_00581	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYK57_00582	COG0393	Putative heavy-metal-binding
CYK57_00583	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CYK57_00585	COG4221	oxidoreductase activity
CYK57_00586	COG0133	tryptophan synthase activity
CYK57_00587	COG0159	tryptophan synthase activity
CYK57_00590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYK57_00590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYK57_00593	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CYK57_00595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYK57_00596	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYK57_00601	COG0640	Transcriptional regulator
CYK57_00603	COG0189	ligase activity
CYK57_00604	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CYK57_00605	COG0280	phosphate acetyltransferase
CYK57_00605	COG0281	malic enzyme
CYK57_00606	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CYK57_00617	COG3723	Recombinational DNA repair protein, rece pathway
CYK57_00629	COG0305	Participates in initiation and elongation during chromosome replication
CYK57_00636	COG3772	lysozyme
CYK57_00642	COG0740	serine-type endopeptidase activity
CYK57_00658	COG3683	transport system, periplasmic component
CYK57_00659	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CYK57_00660	COG1115	amino acid carrier protein
CYK57_00661	COG1116	anion transmembrane transporter activity
CYK57_00662	COG1116	anion transmembrane transporter activity
CYK57_00663	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYK57_00664	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYK57_00665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CYK57_00666	COG2104	thiamine diphosphate biosynthetic process
CYK57_00667	COG2022	thiamine diphosphate biosynthetic process
CYK57_00668	COG2022	thiamine diphosphate biosynthetic process
CYK57_00669	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CYK57_00670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CYK57_00671	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYK57_00672	COG0351	phosphomethylpyrimidine kinase
CYK57_00673	COG0351	phosphomethylpyrimidine kinase
CYK57_00676	COG0481	GTPase activity
CYK57_00678	COG0681	Belongs to the peptidase S26 family
CYK57_00679	COG0571	ribonuclease III activity
CYK57_00680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYK57_00681	COG1381	Involved in DNA repair and RecF pathway recombination
CYK57_00697	COG0433	COG0433 Predicted ATPase
CYK57_00698	COG1840	ABC-type Fe3 transport system, periplasmic component
CYK57_00700	COG4178	(ABC) transporter
CYK57_00702	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYK57_00703	COG2194	sulfuric ester hydrolase activity
CYK57_00704	COG0528	UMP kinase activity
CYK57_00706	COG0233	cytoplasmic translational termination
CYK57_00707	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYK57_00708	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CYK57_00709	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CYK57_00710	COG0590	tRNA wobble adenosine to inosine editing
CYK57_00711	COG0513	Belongs to the DEAD box helicase family
CYK57_00712	COG4785	May be involved in cell division
CYK57_00713	COG1185	polyribonucleotide nucleotidyltransferase activity
CYK57_00714	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYK57_00716	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CYK57_00717	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYK57_00719	COG3083	sulfuric ester hydrolase activity
CYK57_00720	COG3082	Protein of unknown function (DUF1414)
CYK57_00721	COG1309	transcriptional regulator
CYK57_00722	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYK57_00723	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYK57_00724	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYK57_00726	COG3955	Domain of unknown function (DUF1919)
CYK57_00727	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYK57_00730	COG0517	IMP dehydrogenase activity
CYK57_00730	COG0516	GMP reductase activity
CYK57_00731	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CYK57_00732	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYK57_00733	COG0814	amino acid
CYK57_00734	COG0814	amino acid
CYK57_00736	COG3105	Protein conserved in bacteria
CYK57_00737	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYK57_00739	COG3022	response to hydroperoxide
CYK57_00742	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CYK57_00743	COG1823	symporter activity
CYK57_00744	COG0778	Nitroreductase
CYK57_00745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYK57_00746	COG0072	phenylalanine-tRNA ligase activity
CYK57_00747	COG0776	regulation of translation
CYK57_00748	COG0791	NLP P60 protein
CYK57_00749	COG2801	Transposase and inactivated derivatives
CYK57_00750	COG2963	transposase activity
CYK57_00751	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CYK57_00752	COG1940	carbohydrate kinase activity
CYK57_00752	COG1846	Transcriptional regulator
CYK57_00753	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CYK57_00754	COG1522	sequence-specific DNA binding
CYK57_00755	COG1674	ftsk spoiiie
CYK57_00756	COG2321	neutral zinc metallopeptidase
CYK57_00757	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CYK57_00758	COG1214	PFAM Peptidase M22, glycoprotease
CYK57_00759	COG1435	thymidine kinase activity
CYK57_00760	COG3074	FtsZ-dependent cytokinesis
CYK57_00761	COG1494	fructose-1,6-bisphosphatase
CYK57_00762	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CYK57_00763	COG1136	(ABC) transporter
CYK57_00763	COG0577	efflux transmembrane transporter activity
CYK57_00764	COG2205	protein histidine kinase activity
CYK57_00765	COG0745	RESPONSE REGULATOR receiver
CYK57_00766	COG3956	TIGRFAM MazG family protein
CYK57_00767	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYK57_00768	COG0285	dihydrofolate synthase activity
CYK57_00769	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CYK57_00770	COG0732	type I restriction modification DNA specificity domain
CYK57_00772	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CYK57_00774	COG0779	Required for maturation of 30S ribosomal subunits
CYK57_00775	COG0195	Participates in both transcription termination and antitermination
CYK57_00776	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYK57_00777	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYK57_00778	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYK57_00779	COG2951	lytic endotransglycosylase activity
CYK57_00781	COG0857	belongs to the CobB CobQ family
CYK57_00781	COG0280	phosphate acetyltransferase
CYK57_00783	COG0737	Belongs to the 5'-nucleotidase family
CYK57_00788	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYK57_00790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CYK57_00791	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYK57_00792	COG0589	response to stress
CYK57_00794	COG2969	positive regulation of protein catabolic process
CYK57_00795	COG0625	glutathione transferase activity
CYK57_00796	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYK57_00798	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CYK57_00799	COG1448	Aminotransferase
CYK57_00800	COG0006	proline dipeptidase activity
CYK57_00802	COG1487	ribonuclease activity
CYK57_00804	COG0556	nucleotide-excision repair
CYK57_00805	COG2822	iron ion transport
CYK57_00806	COG2837	iron assimilation
CYK57_00808	COG0613	PHP domain protein
CYK57_00810	COG2925	Exonuclease
CYK57_00811	COG0038	chloride channel
CYK57_00812	COG0017	Asparaginyl-tRNA synthetase
CYK57_00813	COG1509	lysine 2,3-aminomutase activity
CYK57_00815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYK57_00816	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYK57_00818	COG2814	Major facilitator Superfamily
CYK57_00819	COG0741	lytic transglycosylase activity
CYK57_00820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CYK57_00821	COG0626	cystathionine gamma-synthase activity
CYK57_00822	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYK57_00823	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CYK57_00825	COG2363	Small membrane protein
CYK57_00826	COG0277	FAD linked oxidase domain protein
CYK57_00827	COG0243	molybdopterin cofactor binding
CYK57_00829	COG3005	denitrification pathway
CYK57_00830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYK57_00831	COG0315	cyclic pyranopterin monophosphate synthase activity
CYK57_00832	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CYK57_00833	COG0314	molybdopterin synthase activity
CYK57_00834	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYK57_00835	COG1444	tRNA N-acetyltransferase activity
CYK57_00837	COG0583	DNA-binding transcription factor activity
CYK57_00839	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYK57_00839	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CYK57_00840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYK57_00843	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CYK57_00844	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CYK57_00847	COG1737	Transcriptional regulator
CYK57_00848	COG2731	YhcH YjgK YiaL family protein
CYK57_00849	COG0248	Ppx GppA phosphatase
CYK57_00850	COG2926	Belongs to the UPF0265 family
CYK57_00851	COG0527	aspartate kinase activity
CYK57_00852	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYK57_00853	COG3100	YcgL domain-containing protein
CYK57_00854	COG0305	Participates in initiation and elongation during chromosome replication
CYK57_00855	COG4607	ABC-type enterochelin transport system periplasmic component
CYK57_00856	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYK57_00857	COG4605	iron ion homeostasis
CYK57_00858	COG4604	ABC transporter, ATP-binding protein
CYK57_00859	COG1392	Phosphate transport regulator
CYK57_00860	COG0306	phosphate transporter
CYK57_00861	COG4991	sh3 domain protein
CYK57_00863	COG3945	hemerythrin HHE cation binding domain
CYK57_00864	COG0343	queuine tRNA-ribosyltransferase activity
CYK57_00867	COG1278	Cold shock
CYK57_00868	COG0288	reversible hydration of carbon dioxide
CYK57_00869	COG0028	Belongs to the TPP enzyme family
CYK57_00870	COG0440	acetolactate synthase activity
CYK57_00871	COG0312	modulator of DNA gyrase
CYK57_00872	COG3028	Belongs to the UPF0307 family
CYK57_00873	COG3094	Invasion gene expression up-regulator, SirB
CYK57_00875	COG1811	Na channel or pump
CYK57_00876	COG3787	Belongs to the UPF0306 family
CYK57_00877	COG0023	Translation Initiation Factor
CYK57_00878	COG0284	orotidine-5'-phosphate decarboxylase activity
CYK57_00879	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CYK57_00880	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CYK57_00881	COG0776	regulation of translation
CYK57_00882	COG0539	negative regulation of cytoplasmic translation
CYK57_00884	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYK57_00886	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYK57_00888	COG1785	Belongs to the alkaline phosphatase family
CYK57_00890	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CYK57_00891	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYK57_00892	COG3264	Mechanosensitive ion channel
CYK57_00892	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYK57_00893	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYK57_00893	COG3264	Mechanosensitive ion channel
CYK57_00894	COG0318	PFAM AMP-dependent synthetase and ligase
CYK57_00895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CYK57_00896	COG0596	Alpha beta hydrolase
CYK57_00897	COG2226	methyltransferase
CYK57_00899	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYK57_00902	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CYK57_00903	COG1380	Effector of murein hydrolase LrgA
CYK57_00904	COG1346	cytolysis
CYK57_00905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYK57_00907	COG3036	rescue of stalled ribosome
CYK57_00908	COG2226	methyltransferase
CYK57_00911	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYK57_00912	COG0658	competence protein
CYK57_00912	COG2333	competence protein COMEC
CYK57_00913	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CYK57_00914	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CYK57_00915	COG0737	Belongs to the 5'-nucleotidase family
CYK57_00920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYK57_00921	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYK57_00922	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CYK57_00923	COG0167	dihydroorotate dehydrogenase activity
CYK57_00924	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYK57_00926	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CYK57_00927	COG1132	(ABC) transporter
CYK57_00928	COG1346	cytolysis
CYK57_00930	COG1199	ATP-dependent helicase activity
CYK57_00932	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYK57_00934	COG0629	single-stranded DNA binding
CYK57_00940	COG2070	2-Nitropropane dioxygenase
CYK57_00943	COG2814	Major facilitator Superfamily
CYK57_00944	COG2315	Protein conserved in bacteria
CYK57_00945	COG4172	Belongs to the ABC transporter superfamily
CYK57_00946	COG4171	peptide transport system, permease
CYK57_00947	COG4168	peptide transport system, permease
CYK57_00948	COG4166	transmembrane transport
CYK57_00949	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CYK57_00950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CYK57_00952	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CYK57_00953	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CYK57_00954	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYK57_00955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYK57_00956	COG1368	sulfuric ester hydrolase activity
CYK57_00957	COG0633	Ferredoxin
CYK57_00957	COG3217	Mosc domain protein beta barrel domain protein
CYK57_00958	COG1722	exodeoxyribonuclease VII activity
CYK57_00959	COG0142	geranyltranstransferase activity
CYK57_00961	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYK57_00963	COG1530	ribonuclease E activity
CYK57_00964	COG1944	ATP diphosphatase activity
CYK57_00967	COG0500	methyltransferase
CYK57_00969	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CYK57_00973	COG2351	hydroxyisourate hydrolase activity
CYK57_00974	COG1609	Transcriptional regulator
CYK57_00975	COG0586	Pfam SNARE associated Golgi protein
CYK57_00976	COG0187	DNA topoisomerase II activity
CYK57_00978	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYK57_00979	COG1349	DNA-binding transcription factor activity
CYK57_00980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYK57_00981	COG2915	High frequency lysogenization protein hflD homolog
CYK57_00982	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CYK57_00983	COG4988	ABC transporter
CYK57_00985	COG2911	Protein conserved in bacteria
CYK57_00986	COG0729	surface antigen
CYK57_00987	COG2861	carbohydrate metabolic process
CYK57_00988	COG4942	peptidase
CYK57_00989	COG0588	phosphoglycerate mutase activity
CYK57_00990	COG1279	arginine transmembrane transporter activity
CYK57_00991	COG0572	uridine kinase
CYK57_00992	COG0717	Belongs to the dCTP deaminase family
CYK57_00993	COG1309	transcriptional regulator
CYK57_00995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYK57_00996	COG0842	Transport permease protein
CYK57_00996	COG1129	ABC transporter
CYK57_00997	COG0842	Transport permease protein
CYK57_00999	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CYK57_01000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CYK57_01001	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CYK57_01002	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CYK57_01002	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CYK57_01003	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CYK57_01004	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYK57_01005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYK57_01006	COG4166	transmembrane transport
CYK57_01008	COG0444	Belongs to the ABC transporter superfamily
CYK57_01009	COG4608	Belongs to the ABC transporter superfamily
CYK57_01011	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYK57_01013	COG0747	negative chemotaxis
CYK57_01014	COG0814	amino acid
CYK57_01015	COG1760	l-serine dehydratase
CYK57_01016	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYK57_01016	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CYK57_01017	COG0134	indole-3-glycerol-phosphate synthase activity
CYK57_01017	COG0135	phosphoribosylanthranilate isomerase activity
CYK57_01018	COG3177	Filamentation induced by cAMP protein fic
CYK57_01019	COG3098	single-species biofilm formation
CYK57_01020	COG0564	pseudouridine synthase activity
CYK57_01021	COG3140	Belongs to the UPF0181 family
CYK57_01023	COG3025	triphosphatase activity
CYK57_01024	COG3106	COG3106 Predicted ATPase
CYK57_01026	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYK57_01027	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYK57_01028	COG1473	amidohydrolase
CYK57_01029	COG3069	C4-dicarboxylate transmembrane transporter activity
CYK57_01030	COG3340	Belongs to the peptidase S51 family
CYK57_01031	COG0495	leucyl-tRNA aminoacylation
CYK57_01032	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CYK57_01033	COG1466	dna polymerase III delta subunit
CYK57_01034	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CYK57_01035	COG0237	dephospho-CoA kinase activity
CYK57_01037	COG1459	type II secretion system
CYK57_01038	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CYK57_01039	COG4969	Belongs to the N-Me-Phe pilin family
CYK57_01040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CYK57_01042	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CYK57_01043	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYK57_01044	COG0730	response to heat
CYK57_01045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CYK57_01046	COG0183	Belongs to the thiolase family
CYK57_01047	COG1024	Enoyl-CoA hydratase
CYK57_01047	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYK57_01050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CYK57_01051	COG3383	formate dehydrogenase (NAD+) activity
CYK57_01051	COG0243	molybdopterin cofactor binding
CYK57_01052	COG0243	molybdopterin cofactor binding
CYK57_01052	COG3383	formate dehydrogenase (NAD+) activity
CYK57_01053	COG0437	4 iron, 4 sulfur cluster binding
CYK57_01054	COG2864	formate dehydrogenase
CYK57_01055	COG3058	Necessary for formate dehydrogenase activity
CYK57_01059	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYK57_01061	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYK57_01062	COG1560	Kdo2-lipid A biosynthetic process
CYK57_01063	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYK57_01066	COG0302	gtp cyclohydrolase
CYK57_01067	COG0302	gtp cyclohydrolase
CYK57_01068	COG0302	gtp cyclohydrolase
CYK57_01069	COG3642	lipopolysaccharide core region biosynthetic process
CYK57_01071	COG0110	maltose O-acetyltransferase activity
CYK57_01073	COG0583	DNA-binding transcription factor activity
CYK57_01077	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CYK57_01078	COG0215	cysteine-tRNA ligase activity
CYK57_01079	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CYK57_01080	COG0617	tRNA 3'-terminal CCA addition
CYK57_01081	COG2963	transposase activity
CYK57_01082	COG2801	Transposase and inactivated derivatives
CYK57_01083	COG2801	Transposase and inactivated derivatives
CYK57_01084	COG2801	Transposase and inactivated derivatives
CYK57_01089	COG2975	iron-sulfur cluster assembly
CYK57_01090	COG0633	Ferredoxin
CYK57_01091	COG0443	Heat shock 70 kDa protein
CYK57_01094	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CYK57_01097	COG0822	iron-sulfur transferase activity
CYK57_01098	COG1104	cysteine desulfurase activity
CYK57_01099	COG1959	2 iron, 2 sulfur cluster binding
CYK57_01101	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CYK57_01102	COG5002	protein histidine kinase activity
CYK57_01102	COG2198	Histidine kinase
CYK57_01102	COG0784	Response regulator, receiver
CYK57_01103	COG0697	spore germination
CYK57_01104	COG2840	Smr protein MutS2
CYK57_01105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CYK57_01106	COG2226	methyltransferase
CYK57_01107	COG2830	Protein of unknown function (DUF452)
CYK57_01108	COG0156	8-amino-7-oxononanoate synthase activity
CYK57_01109	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYK57_01111	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYK57_01112	COG2027	D-alanyl-D-alanine carboxypeptidase
CYK57_01116	COG2801	Transposase and inactivated derivatives
CYK57_01119	COG3620	sequence-specific DNA binding
CYK57_01126	COG1444	tRNA N-acetyltransferase activity
CYK57_01127	COG0138	bifunctional purine biosynthesis protein purh
CYK57_01129	COG3210	domain, Protein
CYK57_01130	COG2831	hemolysin activation secretion protein
CYK57_01131	COG2831	hemolysin activation secretion protein
CYK57_01132	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CYK57_01133	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYK57_01135	COG3078	GTPase activator activity
CYK57_01137	COG0569	domain protein
CYK57_01137	COG2985	domain, Protein
CYK57_01138	COG0786	glutamate:sodium symporter activity
CYK57_01139	COG3112	Uncharacterised protein family (UPF0231)
CYK57_01142	COG2350	Protein conserved in bacteria
CYK57_01143	COG1607	acyl-coa hydrolase
CYK57_01146	COG3092	negative regulation of chromosome organization
CYK57_01148	COG0037	tRNA processing
CYK57_01149	COG2056	Na+-H+ antiporter family
CYK57_01150	COG0708	Exodeoxyribonuclease III
CYK57_01151	COG0583	DNA-binding transcription factor activity
CYK57_01155	COG0254	rRNA binding
CYK57_01157	COG2963	transposase activity
CYK57_01158	COG2801	Transposase and inactivated derivatives
CYK57_01159	COG2801	Transposase and inactivated derivatives
CYK57_01160	COG0326	Molecular chaperone. Has ATPase activity
CYK57_01161	COG0753	catalase activity
CYK57_01162	COG2963	transposase activity
CYK57_01163	COG2801	Transposase and inactivated derivatives
CYK57_01164	COG1408	metallophosphoesterase
CYK57_01165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYK57_01167	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYK57_01168	COG1085	galactose-1-phosphate uridylyltransferase
CYK57_01169	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CYK57_01170	COG2017	converts alpha-aldose to the beta-anomer
CYK57_01174	COG0489	protein tyrosine kinase activity
CYK57_01176	COG2095	MarC family integral membrane protein
CYK57_01177	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYK57_01179	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYK57_01180	COG2354	Protein conserved in bacteria
CYK57_01181	COG3071	HemY protein
CYK57_01182	COG2959	enzyme of heme biosynthesis
CYK57_01184	COG0181	hydroxymethylbilane synthase activity
CYK57_01185	COG1012	belongs to the aldehyde dehydrogenase family
CYK57_01185	COG1454	alcohol dehydrogenase
CYK57_01188	COG0813	purine-nucleoside phosphorylase activity
CYK57_01190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CYK57_01191	COG2364	Membrane
CYK57_01192	COG0800	Aldolase
CYK57_01193	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYK57_01194	COG1904	glucuronate isomerase
CYK57_01196	COG2186	Transcriptional regulator
CYK57_01198	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYK57_01198	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYK57_01199	COG1216	Glycosyl transferase, family 2
CYK57_01200	COG1216	Glycosyl transferase, family 2
CYK57_01202	COG3306	glycosyltransferase involved in LPS biosynthesis
CYK57_01204	COG5039	Polysaccharide pyruvyl transferase
CYK57_01205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CYK57_01206	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CYK57_01207	COG0077	Prephenate dehydratase
CYK57_01207	COG1605	Chorismate mutase
CYK57_01208	COG0339	signal peptide processing
CYK57_01210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CYK57_01211	COG1882	Formate acetyltransferase
CYK57_01212	COG2116	formate transmembrane transporter activity
CYK57_01213	COG1238	metal cluster binding
CYK57_01214	COG0501	Belongs to the peptidase M48B family
CYK57_01215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYK57_01216	COG2431	L-lysine efflux transmembrane transporter activity
CYK57_01217	COG1169	isochorismate synthase
CYK57_01218	COG0436	Aminotransferase
CYK57_01219	COG2962	Rard protein
CYK57_01220	COG2962	Rard protein
CYK57_01221	COG1280	lysine exporter protein (LysE YggA)
CYK57_01222	COG1629	transport
CYK57_01222	COG4771	TonB-dependent receptor
CYK57_01223	COG0748	coenzyme F420 binding
CYK57_01225	COG4235	cytochrome complex assembly
CYK57_01225	COG3088	subunit of a heme lyase
CYK57_01226	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYK57_01227	COG1138	Cytochrome C-type biogenesis protein
CYK57_01228	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYK57_01228	COG0475	glutathione-regulated potassium exporter activity
CYK57_01230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYK57_01231	COG2963	transposase activity
CYK57_01232	COG2801	Transposase and inactivated derivatives
CYK57_01233	COG2801	Transposase and inactivated derivatives
CYK57_01234	COG2801	Transposase and inactivated derivatives
CYK57_01235	COG3111	PFAM Bacterial OB fold (BOF) protein
CYK57_01238	COG0745	RESPONSE REGULATOR receiver
CYK57_01239	COG0642	Histidine kinase
CYK57_01240	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CYK57_01241	COG1862	Preprotein translocase
CYK57_01242	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYK57_01243	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CYK57_01244	COG1528	Iron-storage protein
CYK57_01245	COG1528	Iron-storage protein
CYK57_01246	COG2252	PERMEase
CYK57_01247	COG0424	maF-like protein
CYK57_01249	COG0301	tRNA thio-modification
CYK57_01249	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYK57_01250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYK57_01251	COG0330	HflC and HflK could
CYK57_01252	COG0330	HflC and HflK could
CYK57_01253	COG3118	belongs to the thioredoxin family
CYK57_01255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYK57_01257	COG0531	amino acid
CYK57_01258	COG0531	amino acid
CYK57_01261	COG3047	cAMP biosynthetic process
CYK57_01262	COG0542	response to heat
CYK57_01263	COG0798	PFAM Bile acid sodium symporter
CYK57_01266	COG1027	Aspartate ammonia-lyase
CYK57_01269	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYK57_01270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYK57_01271	COG3064	Membrane
CYK57_01271	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CYK57_01271	COG3583	domain protein
CYK57_01273	COG0720	synthase
CYK57_01274	COG0602	queuosine metabolic process
CYK57_01276	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYK57_01278	COG0795	lipopolysaccharide-transporting ATPase activity
CYK57_01279	COG0795	lipopolysaccharide-transporting ATPase activity
CYK57_01281	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CYK57_01282	COG2937	Belongs to the GPAT DAPAT family
CYK57_01283	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYK57_01284	COG3066	DNA modification
CYK57_01285	COG0861	Integral membrane protein TerC family
CYK57_01286	COG1472	Belongs to the glycosyl hydrolase 3 family
CYK57_01287	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYK57_01288	COG0148	phosphopyruvate hydratase activity
CYK57_01289	COG1051	belongs to the nudix hydrolase family
CYK57_01290	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
CYK57_01292	COG1965	Belongs to the frataxin family
CYK57_01295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYK57_01296	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYK57_01297	COG0564	pseudouridine synthase activity
CYK57_01299	COG0205	6-phosphofructokinase activity
CYK57_01300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYK57_01301	COG1525	nuclease
CYK57_01302	COG1115	amino acid carrier protein
CYK57_01303	COG0628	permease
CYK57_01305	COG0826	peptidase U32
CYK57_01306	COG3307	-O-antigen
CYK57_01307	COG1519	Transferase
CYK57_01308	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYK57_01309	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CYK57_01310	COG0802	atpase or kinase
CYK57_01311	COG1388	LysM domain
CYK57_01311	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYK57_01312	COG0166	Belongs to the GPI family
CYK57_01313	COG2960	long-chain fatty acid transporting porin activity
CYK57_01318	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYK57_01321	COG2137	regulation of response to DNA damage stimulus
CYK57_01322	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYK57_01323	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYK57_01325	COG1322	Protein conserved in bacteria
CYK57_01325	COG1322	Protein conserved in bacteria
CYK57_01326	COG0512	Glutamine amidotransferase of anthranilate synthase
CYK57_01328	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYK57_01329	COG0494	nUDIX hydrolase
CYK57_01330	COG0217	transcriptional regulatory protein
CYK57_01332	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYK57_01333	COG0612	Peptidase, M16
CYK57_01334	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYK57_01335	COG0471	metal ion transport
CYK57_01336	COG0471	metal ion transport
CYK57_01337	COG0583	DNA-binding transcription factor activity
CYK57_01338	COG3266	domain, Protein
CYK57_01339	COG1187	pseudouridine synthase activity
CYK57_01340	COG0009	L-threonylcarbamoyladenylate synthase
CYK57_01341	COG2837	iron assimilation
CYK57_01342	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYK57_01343	COG0512	Glutamine amidotransferase of anthranilate synthase
CYK57_01344	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYK57_01345	COG2226	methyltransferase
CYK57_01346	COG2268	Band 7 protein
CYK57_01347	COG2841	Protein conserved in bacteria
CYK57_01348	COG0359	binds to the 23S rRNA
CYK57_01350	COG2965	DNA replication, synthesis of RNA primer
CYK57_01353	COG3201	nicotinamide mononucleotide transporter
CYK57_01354	COG2976	Protein conserved in bacteria
CYK57_01356	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYK57_01357	COG1426	Protein conserved in bacteria
CYK57_01359	COG0659	secondary active sulfate transmembrane transporter activity
CYK57_01361	COG0165	Argininosuccinate lyase
CYK57_01362	COG0673	inositol 2-dehydrogenase activity
CYK57_01364	COG0475	glutathione-regulated potassium exporter activity
CYK57_01364	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CYK57_01365	COG1373	ATPase (AAA superfamily
CYK57_01375	COG1902	pentaerythritol trinitrate reductase activity
CYK57_01376	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYK57_01380	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CYK57_01381	COG2084	Dehydrogenase
CYK57_01382	COG0778	Nitroreductase
CYK57_01383	COG2095	MarC family integral membrane protein
CYK57_01391	COG0625	glutathione transferase activity
CYK57_01394	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CYK57_01395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CYK57_01398	COG1275	C4-dicarboxylate transporter malic acid transport protein
CYK57_01399	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYK57_01401	COG1132	(ABC) transporter
CYK57_01402	COG1854	S-ribosylhomocysteine lyase activity
CYK57_01403	COG3008	intermembrane lipid transfer
CYK57_01404	COG0735	belongs to the Fur family
CYK57_01405	COG0716	FMN binding
CYK57_01407	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CYK57_01408	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYK57_01409	COG2252	PERMEase
CYK57_01410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CYK57_01411	COG2081	HI0933 family
CYK57_01413	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYK57_01415	COG0560	Phosphoserine phosphatase
CYK57_01416	COG1666	GTP binding
CYK57_01418	COG0058	SHG alpha-glucan phosphorylase activity
CYK57_01419	COG2909	trisaccharide binding
CYK57_01421	COG4580	involved in the transport of maltose and maltodextrins
CYK57_01422	COG3842	ATPase activity
CYK57_01425	COG3833	ABC-type maltose transport systems, permease component
CYK57_01426	COG1640	4-alpha-glucanotransferase
CYK57_01427	COG1966	Carbon starvation protein
CYK57_01428	COG0084	hydrolase, TatD family'
CYK57_01429	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYK57_01432	COG0778	Nitroreductase
CYK57_01435	COG4172	Belongs to the ABC transporter superfamily
CYK57_01436	COG0191	fructose-bisphosphate aldolase activity
CYK57_01437	COG0126	phosphoglycerate kinase activity
CYK57_01438	COG0471	metal ion transport
CYK57_01439	COG0471	metal ion transport
CYK57_01440	COG0471	metal ion transport
CYK57_01441	COG0187	DNA topoisomerase II activity
CYK57_01442	COG5002	protein histidine kinase activity
CYK57_01443	COG0745	RESPONSE REGULATOR receiver
CYK57_01448	COG0789	Transcriptional regulator
CYK57_01450	COG2217	Heavy metal translocating P-type atpase
CYK57_01452	COG0300	oxidoreductase activity
CYK57_01453	COG0778	Nitroreductase
CYK57_01454	COG0616	signal peptide processing
CYK57_01455	COG3719	Belongs to the RNase T2 family
CYK57_01457	COG1252	NADH dehydrogenase
CYK57_01458	COG2183	response to ionizing radiation
CYK57_01459	COG3063	Type IV pilus biogenesis stability protein PilW
CYK57_01460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYK57_01467	COG2161	toxin-antitoxin pair type II binding
CYK57_01468	COG4115	mRNA cleavage
CYK57_01469	COG2835	tetraacyldisaccharide 4'-kinase activity
CYK57_01470	COG1663	tetraacyldisaccharide 4'-kinase activity
CYK57_01471	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYK57_01472	COG0740	serine-type endopeptidase activity
CYK57_01473	COG2166	iron-sulfur cluster assembly
CYK57_01477	COG0488	(ABC) transporter
CYK57_01478	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYK57_01481	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYK57_01482	COG5007	Belongs to the BolA IbaG family
CYK57_01484	COG2854	intermembrane phospholipid transfer
CYK57_01485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CYK57_01486	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYK57_01487	COG1127	ABC transporter
CYK57_01488	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYK57_01489	COG1090	epimerase
CYK57_01490	COG1438	arginine binding
CYK57_01491	COG0039	L-malate dehydrogenase activity
CYK57_01493	COG0563	adenylate kinase activity
CYK57_01495	COG2814	Major facilitator Superfamily
CYK57_01497	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYK57_01498	COG3115	cell septum assembly
CYK57_01501	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYK57_01503	COG4804	nuclease activity
CYK57_01505	COG2814	Major facilitator Superfamily
CYK57_01506	COG0363	glucosamine-6-phosphate deaminase activity
CYK57_01507	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYK57_01508	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYK57_01509	COG0494	nUDIX hydrolase
CYK57_01510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CYK57_01511	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CYK57_01512	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CYK57_01514	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYK57_01515	COG0549	Belongs to the carbamate kinase family
CYK57_01517	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CYK57_01518	COG1178	ABC-type Fe3 transport system permease component
CYK57_01519	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYK57_01520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYK57_01521	COG2190	(PTS) system
CYK57_01522	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYK57_01523	COG0210	DNA helicase
CYK57_01525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYK57_01526	COG0409	Hydrogenase expression formation protein
CYK57_01527	COG0309	Hydrogenase expression formation protein (HypE)
CYK57_01528	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CYK57_01529	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CYK57_01530	COG0437	4 iron, 4 sulfur cluster binding
CYK57_01531	COG5557	Pfam Polysulphide reductase, NrfD
CYK57_01532	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CYK57_01533	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CYK57_01535	COG0298	carbon dioxide binding
CYK57_01536	COG0375	protein maturation
CYK57_01543	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYK57_01544	COG0308	aminopeptidase N
CYK57_01545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CYK57_01546	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYK57_01547	COG0295	cytidine deaminase activity
CYK57_01548	COG2177	Part of the ABC transporter FtsEX involved in
CYK57_01549	COG2884	Cell division ATP-binding protein ftsE
CYK57_01550	COG0552	protein localization to endoplasmic reticulum
CYK57_01551	COG0742	ribosomal rna small subunit methyltransferase
CYK57_01552	COG3099	Belongs to the UPF0263 family
CYK57_01553	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYK57_01555	COG4160	amino acid transport
CYK57_01556	COG4215	(ABC) transporter
CYK57_01557	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYK57_01558	COG1126	abc transporter atp-binding protein
CYK57_01559	COG1881	PFAM PEBP family protein
CYK57_01561	COG3620	sequence-specific DNA binding
CYK57_01563	COG4232	protein-disulfide reductase activity
CYK57_01564	COG3101	peptidyl-lysine hydroxylation
CYK57_01566	COG3107	peptidoglycan biosynthetic process
CYK57_01567	COG0792	nuclease activity
CYK57_01568	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CYK57_01571	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CYK57_01575	COG1138	Cytochrome C-type biogenesis protein
CYK57_01576	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CYK57_01577	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYK57_01578	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYK57_01579	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYK57_01580	COG4133	protoheme IX ABC transporter activity
CYK57_01581	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYK57_01588	COG3630	sodium ion export across plasma membrane
CYK57_01590	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CYK57_01591	COG2824	Alkylphosphonate utilization operon protein PhnA
CYK57_01592	COG1858	cytochrome C peroxidase
CYK57_01593	COG1872	DUF167
CYK57_01594	COG0762	integral membrane protein
CYK57_01595	COG3171	Protein conserved in bacteria
CYK57_01596	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYK57_01597	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYK57_01598	COG0416	fatty acid biosynthetic process
CYK57_01599	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYK57_01600	COG1399	metal-binding, possibly nucleic acid-binding protein
CYK57_01601	COG4137	Cytochrome C assembly protein
CYK57_01602	COG4536	flavin adenine dinucleotide binding
CYK57_01603	COG0733	neurotransmitter:sodium symporter activity
CYK57_01604	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYK57_01604	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYK57_01605	COG3715	PTS system
CYK57_01606	COG3716	PTS system mannose fructose sorbose family IID component
CYK57_01611	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYK57_01612	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYK57_01613	COG0049	tRNA binding
CYK57_01614	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYK57_01615	COG0859	PFAM glycosyl transferase family 9
CYK57_01616	COG0859	PFAM glycosyl transferase family 9
CYK57_01618	COG3061	Opacity-associated protein A
CYK57_01618	COG3266	domain, Protein
CYK57_01619	COG1555	photosystem II stabilization
CYK57_01620	COG0688	phosphatidylethanolamine metabolic process
CYK57_01621	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYK57_01621	COG2918	glutathione biosynthetic process
CYK57_01623	COG0814	amino acid
CYK57_01624	COG3691	Protein conserved in bacteria
CYK57_01625	COG4989	oxidoreductase activity
CYK57_01626	COG1022	Amp-dependent synthetase and ligase
CYK57_01628	COG0579	oxidoreductase
CYK57_01632	COG4211	Belongs to the binding-protein-dependent transport system permease family
CYK57_01633	COG1129	ABC transporter
CYK57_01634	COG1879	ABC-type sugar transport system periplasmic component
CYK57_01635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CYK57_01635	COG2885	chlorophyll binding
CYK57_01636	COG0277	FAD linked oxidase domain protein
CYK57_01636	COG0247	lactate metabolic process
CYK57_01637	COG2050	protein possibly involved in aromatic compounds catabolism
CYK57_01639	COG3005	denitrification pathway
CYK57_01640	COG3043	anaerobic respiration
CYK57_01641	COG0348	domain, Protein
CYK57_01642	COG0437	4 iron, 4 sulfur cluster binding
CYK57_01643	COG0243	molybdopterin cofactor binding
CYK57_01645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CYK57_01646	COG2249	NAD(P)H dehydrogenase (quinone) activity
CYK57_01647	COG2801	Transposase and inactivated derivatives
CYK57_01648	COG2963	transposase activity
CYK57_01650	COG1530	ribonuclease E activity
CYK57_01652	COG1755	Isoprenylcysteine carboxyl methyltransferase
CYK57_01653	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CYK57_01654	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CYK57_01660	COG1840	ABC-type Fe3 transport system, periplasmic component
CYK57_01663	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYK57_01664	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CYK57_01666	COG0678	peroxiredoxin activity
CYK57_01666	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYK57_01667	COG0583	DNA-binding transcription factor activity
CYK57_01668	COG1309	transcriptional regulator
CYK57_01669	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYK57_01670	COG0557	exoribonuclease II activity
CYK57_01672	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYK57_01674	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYK57_01676	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYK57_01677	COG1088	dTDP-glucose 4,6-dehydratase activity
CYK57_01678	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYK57_01683	COG1442	glycosyl transferase family 8
CYK57_01683	COG1216	Glycosyl transferase, family 2
CYK57_01687	COG0316	Belongs to the HesB IscA family
CYK57_01688	COG1575	Belongs to the MenA family. Type 1 subfamily
CYK57_01689	COG4804	nuclease activity
CYK57_01690	COG1720	tRNA m6t6A37 methyltransferase activity
CYK57_01692	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CYK57_01697	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYK57_01698	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYK57_01699	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYK57_01702	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CYK57_01704	COG0825	malonyl-CoA metabolic process
CYK57_01707	COG0204	Acyl-transferase
CYK57_01708	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CYK57_01710	COG2848	UPF0210 protein
CYK57_01713	COG0783	Belongs to the Dps family
CYK57_01716	COG1289	transmembrane transporter activity
CYK57_01717	COG1803	Methylglyoxal synthase
CYK57_01718	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CYK57_01719	COG2963	transposase activity
CYK57_01720	COG2801	Transposase and inactivated derivatives
CYK57_01721	COG0525	valine-tRNA ligase activity
CYK57_01723	COG2153	protein acetylation
CYK57_01724	COG2927	DNA polymerase III (CHI subunit)
CYK57_01725	COG1652	LysM domain
CYK57_01726	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYK57_01727	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CYK57_01728	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CYK57_01729	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYK57_01730	COG1045	serine acetyltransferase
CYK57_01731	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYK57_01736	COG1072	(Pantothenic acid kinase))
CYK57_01737	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYK57_01740	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYK57_01742	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYK57_01743	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYK57_01744	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CYK57_01747	COG0625	glutathione transferase activity
CYK57_01748	COG0019	diaminopimelate decarboxylase activity
CYK57_01750	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CYK57_01751	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CYK57_01752	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CYK57_01753	COG1053	succinate dehydrogenase
CYK57_01754	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CYK57_01756	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYK57_01757	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CYK57_01758	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYK57_01760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CYK57_01761	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CYK57_01762	COG2264	protein methyltransferase activity
CYK57_01766	COG0037	tRNA processing
CYK57_01768	COG4974	Belongs to the 'phage' integrase family
CYK57_01779	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CYK57_01782	COG1151	hydroxylamine reductase activity
CYK57_01783	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CYK57_01784	COG2244	polysaccharide biosynthetic process
CYK57_01785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CYK57_01787	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CYK57_01788	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CYK57_01789	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CYK57_01791	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CYK57_01793	COG0728	peptidoglycan biosynthetic process
CYK57_01794	COG0268	Binds directly to 16S ribosomal RNA
CYK57_01795	COG0569	domain protein
CYK57_01796	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYK57_01797	COG3276	selenocysteine insertion sequence binding
CYK57_01798	COG1921	L-seryl-tRNASec selenium transferase activity
CYK57_01800	COG0716	FMN binding
CYK57_01805	COG4771	TonB-dependent receptor
CYK57_01805	COG1629	transport
CYK57_01810	COG2431	L-lysine efflux transmembrane transporter activity
CYK57_01811	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CYK57_01812	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CYK57_01813	COG3545	Serine hydrolase
CYK57_01815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CYK57_01815	COG0517	IMP dehydrogenase activity
CYK57_01816	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CYK57_01825	COG1119	ATPase activity
CYK57_01826	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYK57_01828	COG1739	Uncharacterized protein family UPF0029
CYK57_01829	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYK57_01830	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CYK57_01831	COG1970	mechanosensitive ion channel activity
CYK57_01832	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYK57_01833	COG0321	lipoyl(octanoyl) transferase activity
CYK57_01834	COG2921	Belongs to the UPF0250 family
CYK57_01835	COG1686	Belongs to the peptidase S11 family
CYK57_01836	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYK57_01837	COG0772	Belongs to the SEDS family
CYK57_01838	COG0768	penicillin binding
CYK57_01839	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CYK57_01840	COG0799	negative regulation of ribosome biogenesis
CYK57_01841	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYK57_01842	COG1126	abc transporter atp-binding protein
CYK57_01843	COG0765	amino acid transport
CYK57_01844	COG3681	Belongs to the UPF0597 family
CYK57_01845	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CYK57_01847	COG3691	Protein conserved in bacteria
CYK57_01850	COG0829	nickel cation binding
CYK57_01851	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYK57_01852	COG0830	nickel cation binding
CYK57_01857	COG0831	urea catabolic process
CYK57_01859	COG1122	ATPase activity
CYK57_01860	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CYK57_01861	COG0310	cobalt ion transport
CYK57_01862	COG0310	cobalt ion transport
CYK57_01863	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CYK57_01864	COG0583	DNA-binding transcription factor activity
CYK57_01866	COG0490	domain, Protein
CYK57_01866	COG0471	metal ion transport
CYK57_01867	COG3722	fumarate hydratase activity
CYK57_01870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYK57_01871	COG1349	DNA-binding transcription factor activity
CYK57_01874	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CYK57_01875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYK57_01876	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYK57_01877	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYK57_01878	COG2900	Belongs to the SlyX family
CYK57_01879	COG0545	Peptidyl-prolyl cis-trans isomerase
CYK57_01880	COG2964	Protein conserved in bacteria
CYK57_01881	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CYK57_01883	COG2168	tRNA wobble position uridine thiolation
CYK57_01889	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYK57_01890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYK57_01891	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYK57_01892	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYK57_01893	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYK57_01894	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYK57_01898	COG0357	Ribosomal RNA small subunit methyltransferase G
CYK57_01899	COG0445	tRNA wobble uridine modification
CYK57_01900	COG0561	phosphatase activity
CYK57_01901	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYK57_01902	COG3012	SEC-C Motif Domain Protein
CYK57_01904	COG3716	PTS system mannose fructose sorbose family IID component
CYK57_01905	COG3715	PTS system
CYK57_01906	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYK57_01906	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYK57_01907	COG2801	Transposase and inactivated derivatives
CYK57_01908	COG2963	transposase activity
CYK57_01909	COG2610	gluconate transmembrane transporter activity
CYK57_01910	COG3265	gluconokinase activity
CYK57_01911	COG1609	Transcriptional regulator
CYK57_01913	COG1869	D-ribose catabolic process
CYK57_01915	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYK57_01916	COG1879	ABC-type sugar transport system periplasmic component
CYK57_01917	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYK57_01918	COG0243	molybdopterin cofactor binding
CYK57_01919	COG0437	4 iron, 4 sulfur cluster binding
CYK57_01920	COG3302	dmso reductase anchor subunit
CYK57_01921	COG3381	protein complex oligomerization
CYK57_01922	COG2221	Nitrite and sulphite reductase 4Fe-4S
CYK57_01922	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CYK57_01927	COG1349	DNA-binding transcription factor activity
CYK57_01929	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
CYK57_01930	COG1070	Carbohydrate kinase
CYK57_01931	COG4154	Belongs to the RbsD FucU family
CYK57_01932	COG0235	Class ii aldolase
CYK57_01933	COG0738	Major facilitator superfamily
CYK57_01934	COG1454	alcohol dehydrogenase
CYK57_01935	COG3477	response to acidic pH
CYK57_01936	COG0765	amino acid transport
CYK57_01938	COG1126	abc transporter atp-binding protein
CYK57_01939	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYK57_01943	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CYK57_01948	COG3623	hexulose-6-phosphate isomerase
CYK57_01949	COG0235	Class ii aldolase
CYK57_01951	COG0545	Peptidyl-prolyl cis-trans isomerase
CYK57_01955	COG4783	chaperone-mediated protein folding
CYK57_01957	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYK57_01959	COG0758	DNA mediated transformation
CYK57_01960	COG1297	OPT oligopeptide transporter protein
CYK57_01964	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYK57_01966	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYK57_01967	COG0081	regulation of translation
CYK57_01968	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYK57_01969	COG0222	ribosome binding
CYK57_01978	COG0085	RNA polymerase activity
CYK57_01982	COG1487	ribonuclease activity
CYK57_01986	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CYK57_01987	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CYK57_01988	COG1489	DNA binding
CYK57_01989	COG0346	lactoylglutathione lyase activity
CYK57_01990	COG1194	a g-specific adenine glycosylase
CYK57_01991	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CYK57_01992	COG0741	lytic transglycosylase activity
CYK57_01997	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYK57_01998	COG0737	Belongs to the 5'-nucleotidase family
CYK57_01999	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYK57_02000	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CYK57_02001	COG3657	addiction module killer protein
CYK57_02002	COG0606	chelatase, subunit chli
CYK57_02004	COG2267	carboxylic ester hydrolase activity
CYK57_02005	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CYK57_02007	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CYK57_02009	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYK57_02010	COG0363	glucosamine-6-phosphate deaminase activity
CYK57_02011	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CYK57_02016	COG0051	transcription antitermination factor activity, RNA binding
CYK57_02017	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYK57_02018	COG0088	Forms part of the polypeptide exit tunnel
CYK57_02019	COG0089	rRNA binding
CYK57_02020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYK57_02021	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYK57_02022	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYK57_02023	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYK57_02024	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYK57_02025	COG0255	Belongs to the universal ribosomal protein uL29 family
CYK57_02026	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYK57_02028	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYK57_02029	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYK57_02030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYK57_02031	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYK57_02032	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYK57_02033	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYK57_02034	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYK57_02035	COG1841	ribosomal large subunit assembly
CYK57_02036	COG0200	Binds to the 23S rRNA
CYK57_02037	COG0201	protein transport
CYK57_02038	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYK57_02039	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYK57_02040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYK57_02041	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYK57_02042	COG0202	RNA polymerase activity
CYK57_02044	COG0228	four-way junction DNA binding
CYK57_02045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYK57_02046	COG0336	Belongs to the RNA methyltransferase TrmD family
CYK57_02047	COG0335	large ribosomal subunit rRNA binding
CYK57_02048	COG2850	peptidyl-arginine hydroxylation
CYK57_02049	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYK57_02050	COG4139	cobalamin transport
CYK57_02059	COG2852	Protein conserved in bacteria
CYK57_02064	COG2832	Protein of unknown function (DUF454)
CYK57_02066	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYK57_02068	COG0084	hydrolase, TatD family'
CYK57_02071	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYK57_02073	COG0470	DNA polymerase III
CYK57_02074	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYK57_02075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYK57_02079	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYK57_02080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CYK57_02081	COG0254	rRNA binding
CYK57_02082	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYK57_02083	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYK57_02084	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CYK57_02085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CYK57_02087	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYK57_02090	COG0442	prolyl-tRNA aminoacylation
CYK57_02092	COG1595	DNA-templated transcription, initiation
CYK57_02093	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYK57_02095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYK57_02097	COG0582	viral genome integration into host DNA
CYK57_02101	COG0786	glutamate:sodium symporter activity
CYK57_02105	COG0640	Transcriptional regulator
CYK57_02112	COG2831	hemolysin activation secretion protein
CYK57_02113	COG3210	domain, Protein
CYK57_02113	COG3210	domain, Protein
CYK57_02120	COG2502	aspartate--ammonia ligase
CYK57_02121	COG1522	sequence-specific DNA binding
CYK57_02122	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CYK57_02124	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CYK57_02130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYK57_02133	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYK57_02135	COG4208	sulfate ABC transporter
CYK57_02136	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYK57_02137	COG1304	FMN binding
CYK57_02139	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYK57_02141	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYK57_02142	COG2995	paraquat-inducible protein a
CYK57_02143	COG1305	Transglutaminase-like
CYK57_02145	COG2608	mercury ion transmembrane transporter activity
CYK57_02147	COG1979	alcohol dehydrogenase
CYK57_02148	COG0583	DNA-binding transcription factor activity
CYK57_02150	COG2171	N-acyltransferase activity
CYK57_02151	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYK57_02153	COG0511	ligase activity, forming carbon-carbon bonds
CYK57_02154	COG0439	Biotin carboxylase
CYK57_02156	COG3084	Protein conserved in bacteria
CYK57_02157	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CYK57_02160	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYK57_02160	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYK57_02161	COG0742	ribosomal rna small subunit methyltransferase
CYK57_02162	COG1876	peptidase activity
CYK57_02163	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYK57_02164	COG1393	Belongs to the ArsC family
CYK57_02166	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYK57_02167	COG0564	pseudouridine synthase activity
CYK57_02169	COG0668	transmembrane transport
CYK57_02170	COG0439	Biotin carboxylase
CYK57_02172	COG1025	Belongs to the peptidase M16 family
CYK57_02173	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CYK57_02178	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYK57_02179	COG1067	ATP-dependent peptidase activity
CYK57_02180	COG3120	sequence-specific DNA binding
CYK57_02181	COG0180	Tryptophanyl-tRNA synthetase
CYK57_02184	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYK57_02185	COG0730	response to heat
CYK57_02190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYK57_02191	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CYK57_02192	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CYK57_02193	COG2116	formate transmembrane transporter activity
CYK57_02196	COG0484	heat shock protein binding
CYK57_02197	COG0443	Heat shock 70 kDa protein
CYK57_02198	COG1070	Carbohydrate kinase
CYK57_02199	COG2115	Belongs to the xylose isomerase family
CYK57_02200	COG4213	ABC transporter substrate-binding protein
CYK57_02201	COG1129	ABC transporter
CYK57_02202	COG4214	carbohydrate transport
CYK57_02203	COG2207	Transcriptional regulator
CYK57_02203	COG1609	Transcriptional regulator
CYK57_02204	COG3590	peptidase
CYK57_02207	COG4145	pantothenate transmembrane transporter activity
CYK57_02208	COG3924	membrane
CYK57_02209	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CYK57_02210	COG2853	Lipoprotein
CYK57_02211	COG0676	glucose-6-phosphate 1-epimerase activity
CYK57_02214	COG0726	polysaccharide deacetylase
CYK57_02214	COG1649	PFAM Uncharacterised BCR, COG1649
CYK57_02215	COG1215	transferase activity, transferring glycosyl groups
CYK57_02217	COG0149	triose-phosphate isomerase activity
CYK57_02219	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYK57_02220	COG1238	metal cluster binding
CYK57_02223	COG1388	LysM domain
CYK57_02223	COG4942	peptidase
CYK57_02224	COG2818	Glycosylase
CYK57_02227	COG0700	Nucleoside recognition
CYK57_02228	COG3366	ferrous iron transmembrane transporter activity
CYK57_02231	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYK57_02232	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CYK57_02233	COG0594	ribonuclease P activity
CYK57_02234	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYK57_02235	COG0174	glutamine synthetase
CYK57_02236	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CYK57_02237	COG0494	nUDIX hydrolase
CYK57_02241	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CYK57_02243	COG1490	D-aminoacyl-tRNA deacylase activity
CYK57_02244	COG1295	ribonuclease BN
CYK57_02245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYK57_02246	COG1629	transport
CYK57_02246	COG4771	TonB-dependent receptor
CYK57_02253	COG1064	alcohol dehydrogenase
CYK57_02255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYK57_02256	COG1923	regulation of RNA biosynthetic process
CYK57_02257	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYK57_02259	COG1694	Mazg nucleotide pyrophosphohydrolase
CYK57_02262	COG1309	transcriptional regulator
CYK57_02264	COG0756	dUTP diphosphatase activity
CYK57_02265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYK57_02266	COG2003	Belongs to the UPF0758 family
CYK57_02267	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYK57_02268	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYK57_02270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CYK57_02271	COG0076	glutamate decarboxylase activity
CYK57_02272	COG0425	Belongs to the sulfur carrier protein TusA family
CYK57_02273	COG2391	methyltransferase activity
CYK57_02274	COG3085	chromosome segregation
CYK57_02275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYK57_02279	COG0598	Magnesium transport protein CorA
CYK57_02280	COG2226	methyltransferase
CYK57_02282	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYK57_02283	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYK57_02284	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYK57_02285	COG0805	protein transport
CYK57_02288	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYK57_02289	COG1114	Component of the transport system for branched-chain amino acids
CYK57_02290	COG1028	Short-chain dehydrogenase reductase Sdr
CYK57_02291	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYK57_02292	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYK57_02293	COG0142	geranyltranstransferase activity
CYK57_02295	COG0431	NADPH-dependent FMN reductase
CYK57_02296	COG2259	Doxx family
CYK57_02297	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYK57_02298	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYK57_02299	COG0697	spore germination
CYK57_02300	COG4783	chaperone-mediated protein folding
CYK57_02302	COG1040	competence protein
CYK57_02303	COG2813	Specifically methylates the guanine in position
CYK57_02305	COG0456	acetyltransferase
CYK57_02306	COG0513	Belongs to the DEAD box helicase family
CYK57_02307	COG0259	pyridoxamine-phosphate oxidase activity
CYK57_02308	COG0747	negative chemotaxis
CYK57_02310	COG1584	GPR1 FUN34 yaaH family protein
CYK57_02311	COG1120	ATPase activity
CYK57_02312	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CYK57_02314	COG4774	siderophore transport
CYK57_02316	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYK57_02317	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYK57_02318	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYK57_02319	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYK57_02321	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CYK57_02321	COG0131	Imidazoleglycerol-phosphate dehydratase
CYK57_02323	COG4804	nuclease activity
CYK57_02324	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYK57_02327	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYK57_02327	COG0140	phosphoribosyl-ATP diphosphatase activity
CYK57_02328	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CYK57_02329	COG0024	Methionine aminopeptidase
CYK57_02332	COG1621	beta-fructofuranosidase activity
CYK57_02333	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYK57_02335	COG4591	ABC-type transport system involved in lipoprotein release permease component
CYK57_02336	COG1136	(ABC) transporter
CYK57_02337	COG4591	ABC-type transport system involved in lipoprotein release permease component
CYK57_02338	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYK57_02344	COG2897	thiosulfate sulfurtransferase activity
CYK57_02345	COG2391	methyltransferase activity