locus-tag	class	description
M6G44_00050	COG0616	signal peptide processing
M6G44_00055	COG0616	signal peptide processing
M6G44_00085	COG0768	penicillin binding
M6G44_00125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M6G44_00195	COG4166	transmembrane transport
M6G44_00230	COG2020	methyltransferase activity
M6G44_00255	COG0018	arginyl-trna synthetase
M6G44_00285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M6G44_00290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M6G44_00295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M6G44_00300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M6G44_00305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M6G44_00310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M6G44_00320	COG0196	riboflavin kinase activity
M6G44_00325	COG3172	ATPase kinase involved in NAD metabolism
M6G44_00330	COG2129	metallophosphoesterase
M6G44_00335	COG0745	RESPONSE REGULATOR receiver
M6G44_00345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M6G44_00350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M6G44_00360	COG1217	gtp-binding protein TYPA
M6G44_00365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M6G44_00375	COG1561	YicC-like family, N-terminal region
M6G44_00380	COG0354	folic acid binding
M6G44_00385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M6G44_00390	COG2197	response regulator
M6G44_00400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M6G44_00435	COG0747	negative chemotaxis
M6G44_00440	COG0747	negative chemotaxis
M6G44_00445	COG0601	transmembrane transport
M6G44_00450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6G44_00455	COG0444	Belongs to the ABC transporter superfamily
M6G44_00460	COG4608	Belongs to the ABC transporter superfamily
M6G44_00475	COG0251	oxidation-reduction process
M6G44_00480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6G44_00485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M6G44_00490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M6G44_00495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M6G44_00500	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M6G44_00505	COG0848	biopolymer transport protein
M6G44_00510	COG0811	peptide transport
M6G44_00520	COG3118	belongs to the thioredoxin family
M6G44_00525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6G44_00525	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M6G44_00525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M6G44_00530	COG1461	Dihydroxyacetone kinase
M6G44_00535	COG2376	Dihydroxyacetone kinase
M6G44_00540	COG0492	ferredoxin-NADP+ reductase activity
M6G44_00550	COG3753	Protein conserved in bacteria
M6G44_00570	COG3030	protein affecting phage T7 exclusion by the F plasmid
M6G44_00585	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M6G44_00610	COG3978	acetolactate synthase activity
M6G44_00625	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M6G44_00630	COG0437	4 iron, 4 sulfur cluster binding
M6G44_00635	COG3301	Polysulphide reductase, NrfD
M6G44_00640	COG5295	Hep Hag repeat protein
M6G44_00640	COG5295	Hep Hag repeat protein
M6G44_00655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6G44_00660	COG1414	Transcriptional regulator
M6G44_00665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M6G44_00675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M6G44_00685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M6G44_00690	COG3068	Protein conserved in bacteria
M6G44_00715	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_00725	COG1278	Cold shock
M6G44_00730	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M6G44_00735	COG0793	Belongs to the peptidase S41A family
M6G44_00740	COG2989	Protein conserved in bacteria
M6G44_00745	COG3108	Peptidase M15
M6G44_00750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6G44_00765	COG0537	adenosine 5'-monophosphoramidase activity
M6G44_00770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M6G44_00775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M6G44_00785	COG1162	GTPase activity
M6G44_00790	COG0583	DNA-binding transcription factor activity
M6G44_00795	COG1011	Hydrolase
M6G44_00800	COG0583	DNA-binding transcription factor activity
M6G44_00810	COG0252	asparaginase activity
M6G44_00820	COG5413	integral membrane protein
M6G44_00835	COG3835	regulator
M6G44_00840	COG2610	gluconate transmembrane transporter activity
M6G44_00845	COG1929	Belongs to the glycerate kinase type-1 family
M6G44_00850	COG1254	Belongs to the acylphosphatase family
M6G44_00855	COG3593	DNA synthesis involved in DNA repair
M6G44_00860	COG1611	Belongs to the LOG family
M6G44_00865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6G44_00875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6G44_00880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M6G44_00880	COG0316	Belongs to the HesB IscA family
M6G44_00885	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M6G44_00890	COG1805	sodium ion transport
M6G44_00895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M6G44_00900	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M6G44_00905	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M6G44_00910	COG2871	sodium ion transport
M6G44_00915	COG1477	protein flavinylation
M6G44_00920	COG2991	Protein conserved in bacteria
M6G44_00930	COG2814	Major facilitator Superfamily
M6G44_00935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6G44_00945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M6G44_00970	COG2878	Part of a membrane complex involved in electron transport
M6G44_00975	COG4656	Part of a membrane complex involved in electron transport
M6G44_01000	COG1560	Kdo2-lipid A biosynthetic process
M6G44_01005	COG0402	S-adenosylhomocysteine deaminase activity
M6G44_01010	COG4143	(ABC) transporter
M6G44_01015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M6G44_01020	COG0617	tRNA 3'-terminal CCA addition
M6G44_01025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M6G44_01035	COG2911	Protein conserved in bacteria
M6G44_01045	COG0346	lactoylglutathione lyase activity
M6G44_01050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M6G44_01060	COG0287	Prephenate dehydrogenase
M6G44_01060	COG1605	Chorismate mutase
M6G44_01065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M6G44_01070	COG0859	PFAM glycosyl transferase family 9
M6G44_01075	COG0469	pyruvate kinase activity
M6G44_01080	COG2062	phosphohistidine phosphatase, SixA
M6G44_01085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6G44_01090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M6G44_01095	COG0733	neurotransmitter:sodium symporter activity
M6G44_01100	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M6G44_01105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M6G44_01110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M6G44_01115	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M6G44_01120	COG4972	Pilus assembly protein
M6G44_01140	COG4796	Type ii and iii secretion system protein
M6G44_01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M6G44_01150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M6G44_01155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M6G44_01160	COG1280	lysine exporter protein (LysE YggA)
M6G44_01165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6G44_01190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M6G44_01245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M6G44_01250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M6G44_01255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M6G44_01270	COG1253	flavin adenine dinucleotide binding
M6G44_01275	COG0564	pseudouridine synthase activity
M6G44_01280	COG0588	phosphoglycerate mutase activity
M6G44_01290	COG1678	Uncharacterized ACR, COG1678
M6G44_01295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M6G44_01305	COG0271	Belongs to the BolA IbaG family
M6G44_01340	COG0494	nUDIX hydrolase
M6G44_01345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M6G44_01355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M6G44_01370	COG1629	transport
M6G44_01370	COG4771	TonB-dependent receptor
M6G44_01375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M6G44_01380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M6G44_01385	COG0083	homoserine kinase activity
M6G44_01390	COG0460	homoserine dehydrogenase
M6G44_01390	COG0527	aspartate kinase activity
M6G44_01395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M6G44_01400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M6G44_01405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M6G44_01435	COG2195	Cleaves the N-terminal amino acid of tripeptides
M6G44_01440	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M6G44_01445	COG0194	GDP metabolic process
M6G44_01450	COG1538	Outer membrane efflux protein
M6G44_01455	COG2914	Belongs to the UPF0125 (RnfH) family
M6G44_01460	COG2867	negative regulation of translational initiation
M6G44_01465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M6G44_01470	COG4149	molybdate abc transporter
M6G44_01475	COG0725	ABC transporter, periplasmic molybdate-binding protein
M6G44_01480	COG0842	Transport permease protein
M6G44_01485	COG1131	(ABC) transporter
M6G44_01490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M6G44_01495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M6G44_01505	COG0251	oxidation-reduction process
M6G44_01515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M6G44_01520	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_01525	COG1121	(ABC) transporter
M6G44_01535	COG2920	part of a sulfur-relay system
M6G44_01540	COG0670	Belongs to the BI1 family
M6G44_01545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M6G44_01560	COG0084	hydrolase, TatD family'
M6G44_01565	COG0210	DNA helicase
M6G44_01570	COG3842	ATPase activity
M6G44_01575	COG1176	ABC-type spermidine putrescine transport system, permease component I
M6G44_01580	COG1177	transmembrane transport
M6G44_01595	COG2255	four-way junction helicase activity
M6G44_01605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M6G44_01630	COG0732	type I restriction modification DNA specificity domain
M6G44_01645	COG0488	(ABC) transporter
M6G44_01650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M6G44_01660	COG1271	oxidase subunit
M6G44_01665	COG1294	oxidase, subunit
M6G44_01680	COG0824	Thioesterase
M6G44_01685	COG0811	peptide transport
M6G44_01690	COG0848	biopolymer transport protein
M6G44_01695	COG3064	Membrane
M6G44_01695	COG3064	Membrane
M6G44_01700	COG0823	Involved in the tonB-independent uptake of proteins
M6G44_01715	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M6G44_01720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6G44_01730	COG0488	(ABC) transporter
M6G44_01740	COG0303	'Molybdopterin
M6G44_01745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6G44_01755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M6G44_01760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M6G44_01770	COG0564	pseudouridine synthase activity
M6G44_01775	COG3023	N-Acetylmuramoyl-L-alanine amidase
M6G44_01780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M6G44_01785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M6G44_01790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M6G44_01795	COG0626	cystathionine gamma-synthase activity
M6G44_01800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M6G44_01815	COG1702	phosphate starvation-inducible protein PhoH
M6G44_01840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6G44_01860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6G44_01870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6G44_01875	COG1137	ATPase activity
M6G44_01880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M6G44_01890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M6G44_01895	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M6G44_01905	COG1704	LemA family
M6G44_01910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6G44_01910	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M6G44_01910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6G44_01915	COG1105	Belongs to the carbohydrate kinase PfkB family
M6G44_01920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6G44_01920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6G44_01930	COG1523	belongs to the glycosyl hydrolase 13 family
M6G44_01935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M6G44_01940	COG0297	glycogen (starch) synthase activity
M6G44_01945	COG0058	SHG alpha-glucan phosphorylase activity
M6G44_01970	COG1187	pseudouridine synthase activity
M6G44_01975	COG2814	Major facilitator Superfamily
M6G44_01985	COG3381	protein complex oligomerization
M6G44_01995	COG0791	NLP P60 protein
M6G44_02000	COG2932	Transcriptional regulator
M6G44_02005	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M6G44_02010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M6G44_02015	COG2990	Protein conserved in bacteria
M6G44_02025	COG1643	Atp-dependent helicase
M6G44_02030	COG2707	UPF0756 membrane protein
M6G44_02040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M6G44_02045	COG0534	Mate efflux family protein
M6G44_02050	COG1074	ATP-dependent DNA helicase activity
M6G44_02055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M6G44_02060	COG4535	Mg2 and Co2 transporter CorC
M6G44_02070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6G44_02075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M6G44_02080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M6G44_02085	COG2271	Major facilitator Superfamily
M6G44_02095	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_02105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M6G44_02110	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
M6G44_02115	COG0247	lactate metabolic process
M6G44_02145	COG0517	IMP dehydrogenase activity
M6G44_02145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M6G44_02155	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M6G44_02160	COG0385	Bile acid
M6G44_02165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6G44_02170	COG0561	phosphatase activity
M6G44_02180	COG1595	DNA-templated transcription, initiation
M6G44_02185	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M6G44_02195	COG0318	PFAM AMP-dependent synthetase and ligase
M6G44_02200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M6G44_02210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M6G44_02215	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M6G44_02220	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M6G44_02220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M6G44_02235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M6G44_02250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M6G44_02255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M6G44_02270	COG0750	zinc metalloprotease
M6G44_02275	COG0575	Belongs to the CDS family
M6G44_02280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M6G44_02295	COG0671	phosphoesterase, PA-phosphatase related
M6G44_02300	COG1534	Rna-binding protein
M6G44_02305	COG0463	Glycosyl transferase, family 2
M6G44_02310	COG1686	Belongs to the peptidase S11 family
M6G44_02315	COG0859	PFAM glycosyl transferase family 9
M6G44_02325	COG0328	RNA-DNA hybrid ribonuclease activity
M6G44_02330	COG1286	toxin biosynthetic process
M6G44_02335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M6G44_02345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M6G44_02350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M6G44_02360	COG0251	oxidation-reduction process
M6G44_02365	COG1496	oxidoreductase activity
M6G44_02375	COG5645	(Lipo)protein
M6G44_02390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M6G44_02400	COG1792	Involved in formation and maintenance of cell shape
M6G44_02405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M6G44_02410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M6G44_02415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M6G44_02420	COG0121	glutamine amidotransferase
M6G44_02425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M6G44_02430	COG2949	membrane
M6G44_02440	COG1556	Lactate utilization protein
M6G44_02445	COG1139	Iron-sulfur cluster binding protein
M6G44_02450	COG0247	lactate metabolic process
M6G44_02455	COG1620	l-lactate permease
M6G44_02460	COG2916	Histone family protein nucleoid-structuring protein H-NS
M6G44_02465	COG1757	Na H antiporter
M6G44_02470	COG1879	ABC-type sugar transport system periplasmic component
M6G44_02475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M6G44_02485	COG2990	Protein conserved in bacteria
M6G44_02490	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6G44_02495	COG0567	Dehydrogenase, E1 component
M6G44_02500	COG1121	(ABC) transporter
M6G44_02505	COG0739	heme binding
M6G44_02510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M6G44_02515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M6G44_02525	COG0561	phosphatase activity
M6G44_02530	COG3850	Histidine kinase
M6G44_02540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M6G44_02550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M6G44_02560	COG4221	oxidoreductase activity
M6G44_02585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6G44_02585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6G44_02600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M6G44_02610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6G44_02615	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M6G44_02640	COG0640	Transcriptional regulator
M6G44_02650	COG0189	ligase activity
M6G44_02655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M6G44_02660	COG0281	malic enzyme
M6G44_02660	COG0280	phosphate acetyltransferase
M6G44_02675	COG3683	transport system, periplasmic component
M6G44_02680	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M6G44_02685	COG1115	amino acid carrier protein
M6G44_02695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6G44_02700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6G44_02715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M6G44_02720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6G44_02735	COG0481	GTPase activity
M6G44_02740	COG0681	Belongs to the peptidase S26 family
M6G44_02745	COG0571	ribonuclease III activity
M6G44_02750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M6G44_02755	COG1381	Involved in DNA repair and RecF pathway recombination
M6G44_02835	COG1840	ABC-type Fe3 transport system, periplasmic component
M6G44_02865	COG2194	sulfuric ester hydrolase activity
M6G44_02870	COG0528	UMP kinase activity
M6G44_02875	COG0233	cytoplasmic translational termination
M6G44_02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6G44_02885	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M6G44_02895	COG0590	tRNA wobble adenosine to inosine editing
M6G44_02900	COG0513	Belongs to the DEAD box helicase family
M6G44_02905	COG4785	May be involved in cell division
M6G44_02910	COG1185	polyribonucleotide nucleotidyltransferase activity
M6G44_02915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M6G44_02930	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M6G44_02960	COG3083	sulfuric ester hydrolase activity
M6G44_02970	COG1309	transcriptional regulator
M6G44_02975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6G44_02980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6G44_02995	COG3955	Domain of unknown function (DUF1919)
M6G44_03000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M6G44_03015	COG0517	IMP dehydrogenase activity
M6G44_03015	COG0516	GMP reductase activity
M6G44_03020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M6G44_03025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M6G44_03030	COG0814	amino acid
M6G44_03035	COG0814	amino acid
M6G44_03045	COG3105	Protein conserved in bacteria
M6G44_03050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M6G44_03075	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M6G44_03080	COG1823	symporter activity
M6G44_03085	COG0778	Nitroreductase
M6G44_03095	COG0072	phenylalanine-tRNA ligase activity
M6G44_03100	COG0776	regulation of translation
M6G44_03105	COG0791	NLP P60 protein
M6G44_03115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M6G44_03120	COG1940	carbohydrate kinase activity
M6G44_03120	COG1846	Transcriptional regulator
M6G44_03125	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M6G44_03130	COG1522	sequence-specific DNA binding
M6G44_03135	COG1674	ftsk spoiiie
M6G44_03140	COG2321	neutral zinc metallopeptidase
M6G44_03145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M6G44_03150	COG1214	PFAM Peptidase M22, glycoprotease
M6G44_03155	COG1435	thymidine kinase activity
M6G44_03160	COG3074	FtsZ-dependent cytokinesis
M6G44_03165	COG1494	fructose-1,6-bisphosphatase
M6G44_03170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M6G44_03175	COG0577	efflux transmembrane transporter activity
M6G44_03175	COG1136	(ABC) transporter
M6G44_03180	COG2205	protein histidine kinase activity
M6G44_03185	COG0745	RESPONSE REGULATOR receiver
M6G44_03190	COG3956	TIGRFAM MazG family protein
M6G44_03200	COG0285	dihydrofolate synthase activity
M6G44_03210	COG0779	Required for maturation of 30S ribosomal subunits
M6G44_03215	COG0195	Participates in both transcription termination and antitermination
M6G44_03220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M6G44_03225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M6G44_03230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M6G44_03235	COG2951	lytic endotransglycosylase activity
M6G44_03245	COG0857	belongs to the CobB CobQ family
M6G44_03245	COG0280	phosphate acetyltransferase
M6G44_03255	COG0737	Belongs to the 5'-nucleotidase family
M6G44_03275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M6G44_03285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M6G44_03295	COG0589	response to stress
M6G44_03305	COG2969	positive regulation of protein catabolic process
M6G44_03310	COG0625	glutathione transferase activity
M6G44_03315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M6G44_03325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M6G44_03330	COG1448	Aminotransferase
M6G44_03335	COG0006	proline dipeptidase activity
M6G44_03345	COG1487	ribonuclease activity
M6G44_03355	COG0556	nucleotide-excision repair
M6G44_03360	COG2822	iron ion transport
M6G44_03365	COG2837	iron assimilation
M6G44_03375	COG0613	PHP domain protein
M6G44_03385	COG2925	Exonuclease
M6G44_03390	COG0038	chloride channel
M6G44_03395	COG0017	Asparaginyl-tRNA synthetase
M6G44_03400	COG1509	lysine 2,3-aminomutase activity
M6G44_03410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M6G44_03415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M6G44_03420	COG2814	Major facilitator Superfamily
M6G44_03425	COG0741	lytic transglycosylase activity
M6G44_03430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M6G44_03435	COG0626	cystathionine gamma-synthase activity
M6G44_03440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M6G44_03445	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M6G44_03450	COG2363	Small membrane protein
M6G44_03455	COG0277	FAD linked oxidase domain protein
M6G44_03460	COG0243	molybdopterin cofactor binding
M6G44_03465	COG3005	denitrification pathway
M6G44_03470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M6G44_03475	COG0315	cyclic pyranopterin monophosphate synthase activity
M6G44_03480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M6G44_03485	COG0314	molybdopterin synthase activity
M6G44_03490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M6G44_03495	COG1444	tRNA N-acetyltransferase activity
M6G44_03505	COG0583	DNA-binding transcription factor activity
M6G44_03530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M6G44_03535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6G44_03550	COG1737	Transcriptional regulator
M6G44_03555	COG2731	YhcH YjgK YiaL family protein
M6G44_03560	COG0248	Ppx GppA phosphatase
M6G44_03570	COG0527	aspartate kinase activity
M6G44_03575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M6G44_03580	COG3100	YcgL domain-containing protein
M6G44_03585	COG0305	Participates in initiation and elongation during chromosome replication
M6G44_03590	COG4607	ABC-type enterochelin transport system periplasmic component
M6G44_03595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6G44_03600	COG4605	iron ion homeostasis
M6G44_03605	COG4604	ABC transporter, ATP-binding protein
M6G44_03610	COG1392	Phosphate transport regulator
M6G44_03615	COG0306	phosphate transporter
M6G44_03620	COG4991	sh3 domain protein
M6G44_03630	COG3945	hemerythrin HHE cation binding domain
M6G44_03635	COG0343	queuine tRNA-ribosyltransferase activity
M6G44_03645	COG1278	Cold shock
M6G44_03650	COG0288	reversible hydration of carbon dioxide
M6G44_03655	COG0028	Belongs to the TPP enzyme family
M6G44_03660	COG0440	acetolactate synthase activity
M6G44_03665	COG0312	modulator of DNA gyrase
M6G44_03670	COG3028	Belongs to the UPF0307 family
M6G44_03675	COG3094	Invasion gene expression up-regulator, SirB
M6G44_03685	COG1811	Na channel or pump
M6G44_03690	COG3787	Belongs to the UPF0306 family
M6G44_03695	COG0023	Translation Initiation Factor
M6G44_03700	COG0284	orotidine-5'-phosphate decarboxylase activity
M6G44_03705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M6G44_03710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M6G44_03715	COG0776	regulation of translation
M6G44_03720	COG0539	negative regulation of cytoplasmic translation
M6G44_03730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6G44_03740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M6G44_03750	COG1785	Belongs to the alkaline phosphatase family
M6G44_03755	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
M6G44_03765	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M6G44_03765	COG3264	Mechanosensitive ion channel
M6G44_03770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M6G44_03770	COG3264	Mechanosensitive ion channel
M6G44_03775	COG0318	PFAM AMP-dependent synthetase and ligase
M6G44_03780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M6G44_03785	COG0596	Alpha beta hydrolase
M6G44_03795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M6G44_03815	COG1380	Effector of murein hydrolase LrgA
M6G44_03820	COG1346	cytolysis
M6G44_03825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M6G44_03835	COG0582	viral genome integration into host DNA
M6G44_03890	COG4626	Terminase
M6G44_03890	COG1802	Transcriptional regulator
M6G44_03935	COG3036	rescue of stalled ribosome
M6G44_03940	COG2226	methyltransferase
M6G44_03960	COG0658	competence protein
M6G44_03960	COG2333	competence protein COMEC
M6G44_03965	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M6G44_03970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M6G44_03975	COG0737	Belongs to the 5'-nucleotidase family
M6G44_03995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6G44_04000	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6G44_04005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M6G44_04015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M6G44_04030	COG1132	(ABC) transporter
M6G44_04035	COG1346	cytolysis
M6G44_04045	COG1199	ATP-dependent helicase activity
M6G44_04055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6G44_04060	COG0629	single-stranded DNA binding
M6G44_04110	COG2132	Multicopper oxidase
M6G44_04170	COG2070	2-Nitropropane dioxygenase
M6G44_04180	COG2315	Protein conserved in bacteria
M6G44_04185	COG4172	Belongs to the ABC transporter superfamily
M6G44_04190	COG4171	peptide transport system, permease
M6G44_04195	COG4168	peptide transport system, permease
M6G44_04200	COG4166	transmembrane transport
M6G44_04205	COG3283	Transcriptional regulator of aromatic amino acids metabolism
M6G44_04210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M6G44_04220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M6G44_04240	COG1368	sulfuric ester hydrolase activity
M6G44_04245	COG0633	Ferredoxin
M6G44_04245	COG3217	Mosc domain protein beta barrel domain protein
M6G44_04250	COG1722	exodeoxyribonuclease VII activity
M6G44_04255	COG0142	geranyltranstransferase activity
M6G44_04270	COG1530	ribonuclease E activity
M6G44_04275	COG1944	ATP diphosphatase activity
M6G44_04290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M6G44_04310	COG2351	hydroxyisourate hydrolase activity
M6G44_04320	COG0586	Pfam SNARE associated Golgi protein
M6G44_04325	COG0187	DNA topoisomerase II activity
M6G44_04330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M6G44_04335	COG1349	DNA-binding transcription factor activity
M6G44_04340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M6G44_04345	COG2915	High frequency lysogenization protein hflD homolog
M6G44_04350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M6G44_04355	COG4988	ABC transporter
M6G44_04360	COG2911	Protein conserved in bacteria
M6G44_04365	COG0729	surface antigen
M6G44_04370	COG2861	carbohydrate metabolic process
M6G44_04375	COG4942	peptidase
M6G44_04380	COG0588	phosphoglycerate mutase activity
M6G44_04390	COG0572	uridine kinase
M6G44_04395	COG0717	Belongs to the dCTP deaminase family
M6G44_04400	COG1309	transcriptional regulator
M6G44_04405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6G44_04410	COG1129	ABC transporter
M6G44_04410	COG0842	Transport permease protein
M6G44_04415	COG0842	Transport permease protein
M6G44_04425	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M6G44_04430	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M6G44_04435	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M6G44_04445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M6G44_04450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M6G44_04455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6G44_04460	COG4166	transmembrane transport
M6G44_04470	COG0444	Belongs to the ABC transporter superfamily
M6G44_04475	COG4608	Belongs to the ABC transporter superfamily
M6G44_04485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M6G44_04495	COG0747	negative chemotaxis
M6G44_04500	COG0814	amino acid
M6G44_04505	COG1760	l-serine dehydratase
M6G44_04515	COG0134	indole-3-glycerol-phosphate synthase activity
M6G44_04515	COG0135	phosphoribosylanthranilate isomerase activity
M6G44_04520	COG3177	Filamentation induced by cAMP protein fic
M6G44_04525	COG3098	single-species biofilm formation
M6G44_04530	COG0564	pseudouridine synthase activity
M6G44_04535	COG3140	Belongs to the UPF0181 family
M6G44_04545	COG3025	triphosphatase activity
M6G44_04550	COG3106	COG3106 Predicted ATPase
M6G44_04555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M6G44_04565	COG1473	amidohydrolase
M6G44_04570	COG3069	C4-dicarboxylate transmembrane transporter activity
M6G44_04580	COG0495	leucyl-tRNA aminoacylation
M6G44_04585	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M6G44_04590	COG1466	dna polymerase III delta subunit
M6G44_04595	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M6G44_04600	COG0237	dephospho-CoA kinase activity
M6G44_04610	COG1459	type II secretion system
M6G44_04615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M6G44_04620	COG4969	Belongs to the N-Me-Phe pilin family
M6G44_04625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M6G44_04635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M6G44_04640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M6G44_04645	COG0730	response to heat
M6G44_04650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M6G44_04655	COG0183	Belongs to the thiolase family
M6G44_04660	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6G44_04660	COG1024	Enoyl-CoA hydratase
M6G44_04675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M6G44_04685	COG0437	4 iron, 4 sulfur cluster binding
M6G44_04690	COG2864	formate dehydrogenase
M6G44_04695	COG3058	Necessary for formate dehydrogenase activity
M6G44_04725	COG1560	Kdo2-lipid A biosynthetic process
M6G44_04730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M6G44_04740	COG0302	gtp cyclohydrolase
M6G44_04745	COG3642	lipopolysaccharide core region biosynthetic process
M6G44_04755	COG0110	maltose O-acetyltransferase activity
M6G44_04765	COG0583	DNA-binding transcription factor activity
M6G44_04785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M6G44_04795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M6G44_04800	COG0617	tRNA 3'-terminal CCA addition
M6G44_04825	COG2975	iron-sulfur cluster assembly
M6G44_04830	COG0633	Ferredoxin
M6G44_04850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M6G44_04860	COG0822	iron-sulfur transferase activity
M6G44_04865	COG1104	cysteine desulfurase activity
M6G44_04870	COG1959	2 iron, 2 sulfur cluster binding
M6G44_04880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M6G44_04885	COG0784	Response regulator, receiver
M6G44_04885	COG2198	Histidine kinase
M6G44_04885	COG5002	protein histidine kinase activity
M6G44_04890	COG0697	spore germination
M6G44_04895	COG2840	Smr protein MutS2
M6G44_04900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M6G44_04905	COG2226	methyltransferase
M6G44_04910	COG2830	Protein of unknown function (DUF452)
M6G44_04915	COG0156	8-amino-7-oxononanoate synthase activity
M6G44_04920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6G44_04930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M6G44_04935	COG2027	D-alanyl-D-alanine carboxypeptidase
M6G44_04950	COG2801	Transposase and inactivated derivatives
M6G44_04970	COG1444	tRNA N-acetyltransferase activity
M6G44_04975	COG0138	bifunctional purine biosynthesis protein purh
M6G44_04980	COG2801	Transposase and inactivated derivatives
M6G44_05005	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_05025	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M6G44_05030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6G44_05050	COG0786	glutamate:sodium symporter activity
M6G44_05065	COG2350	Protein conserved in bacteria
M6G44_05070	COG1607	acyl-coa hydrolase
M6G44_05085	COG3092	negative regulation of chromosome organization
M6G44_05095	COG2056	Na+-H+ antiporter family
M6G44_05100	COG0708	Exodeoxyribonuclease III
M6G44_05105	COG0583	DNA-binding transcription factor activity
M6G44_05125	COG0254	rRNA binding
M6G44_05140	COG0753	catalase activity
M6G44_05145	COG2963	transposase activity
M6G44_05155	COG1408	metallophosphoesterase
M6G44_05160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6G44_05165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6G44_05170	COG1085	galactose-1-phosphate uridylyltransferase
M6G44_05180	COG2017	converts alpha-aldose to the beta-anomer
M6G44_05220	COG0489	protein tyrosine kinase activity
M6G44_05230	COG2095	MarC family integral membrane protein
M6G44_05235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M6G44_05245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M6G44_05250	COG2354	Protein conserved in bacteria
M6G44_05255	COG3071	HemY protein
M6G44_05260	COG2959	enzyme of heme biosynthesis
M6G44_05270	COG0181	hydroxymethylbilane synthase activity
M6G44_05275	COG1454	alcohol dehydrogenase
M6G44_05275	COG1012	belongs to the aldehyde dehydrogenase family
M6G44_05290	COG0813	purine-nucleoside phosphorylase activity
M6G44_05300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6G44_05305	COG2364	Membrane
M6G44_05310	COG0800	Aldolase
M6G44_05315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M6G44_05320	COG1904	glucuronate isomerase
M6G44_05330	COG2186	Transcriptional regulator
M6G44_05340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6G44_05340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6G44_05345	COG1216	Glycosyl transferase, family 2
M6G44_05350	COG1216	Glycosyl transferase, family 2
M6G44_05360	COG3306	glycosyltransferase involved in LPS biosynthesis
M6G44_05370	COG5039	Polysaccharide pyruvyl transferase
M6G44_05375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M6G44_05380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M6G44_05385	COG0077	Prephenate dehydratase
M6G44_05385	COG1605	Chorismate mutase
M6G44_05390	COG0339	signal peptide processing
M6G44_05395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M6G44_05400	COG1882	Formate acetyltransferase
M6G44_05405	COG2116	formate transmembrane transporter activity
M6G44_05410	COG1238	metal cluster binding
M6G44_05415	COG0501	Belongs to the peptidase M48B family
M6G44_05425	COG2431	L-lysine efflux transmembrane transporter activity
M6G44_05430	COG1169	isochorismate synthase
M6G44_05435	COG0436	Aminotransferase
M6G44_05445	COG2962	Rard protein
M6G44_05450	COG1280	lysine exporter protein (LysE YggA)
M6G44_05455	COG1629	transport
M6G44_05455	COG4771	TonB-dependent receptor
M6G44_05460	COG0748	coenzyme F420 binding
M6G44_05470	COG3088	subunit of a heme lyase
M6G44_05470	COG4235	cytochrome complex assembly
M6G44_05475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6G44_05480	COG1138	Cytochrome C-type biogenesis protein
M6G44_05485	COG0475	glutathione-regulated potassium exporter activity
M6G44_05485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M6G44_05495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M6G44_05505	COG3111	PFAM Bacterial OB fold (BOF) protein
M6G44_05525	COG0745	RESPONSE REGULATOR receiver
M6G44_05530	COG0642	Histidine kinase
M6G44_05535	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M6G44_05540	COG1862	Preprotein translocase
M6G44_05545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6G44_05550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6G44_05555	COG1528	Iron-storage protein
M6G44_05560	COG1528	Iron-storage protein
M6G44_05565	COG2252	PERMEase
M6G44_05570	COG0424	maF-like protein
M6G44_05580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6G44_05580	COG0301	tRNA thio-modification
M6G44_05590	COG0330	HflC and HflK could
M6G44_05595	COG0330	HflC and HflK could
M6G44_05600	COG3118	belongs to the thioredoxin family
M6G44_05620	COG0531	amino acid
M6G44_05625	COG0531	amino acid
M6G44_05640	COG3047	cAMP biosynthetic process
M6G44_05645	COG0542	response to heat
M6G44_05650	COG0798	PFAM Bile acid sodium symporter
M6G44_05655	COG1393	Belongs to the ArsC family
M6G44_05665	COG1027	Aspartate ammonia-lyase
M6G44_05675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M6G44_05680	COG3583	domain protein
M6G44_05680	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M6G44_05680	COG3064	Membrane
M6G44_05690	COG0720	synthase
M6G44_05695	COG0602	queuosine metabolic process
M6G44_05720	COG0795	lipopolysaccharide-transporting ATPase activity
M6G44_05725	COG0795	lipopolysaccharide-transporting ATPase activity
M6G44_05750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M6G44_05770	COG0861	Integral membrane protein TerC family
M6G44_05775	COG1472	Belongs to the glycosyl hydrolase 3 family
M6G44_05785	COG0148	phosphopyruvate hydratase activity
M6G44_05790	COG1051	belongs to the nudix hydrolase family
M6G44_05795	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
M6G44_05815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M6G44_05820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M6G44_05825	COG0564	pseudouridine synthase activity
M6G44_05835	COG0205	6-phosphofructokinase activity
M6G44_05840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M6G44_05845	COG1525	nuclease
M6G44_05850	COG1115	amino acid carrier protein
M6G44_05855	COG0628	permease
M6G44_05865	COG0826	peptidase U32
M6G44_05870	COG3307	-O-antigen
M6G44_05875	COG1519	Transferase
M6G44_05885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M6G44_05890	COG0802	atpase or kinase
M6G44_05895	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6G44_05895	COG1388	LysM domain
M6G44_05900	COG0166	Belongs to the GPI family
M6G44_05905	COG2960	long-chain fatty acid transporting porin activity
M6G44_05925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M6G44_05935	COG0551	DNA topoisomerase type I activity
M6G44_05945	COG2137	regulation of response to DNA damage stimulus
M6G44_05950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M6G44_05955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6G44_05965	COG1322	Protein conserved in bacteria
M6G44_05970	COG0512	Glutamine amidotransferase of anthranilate synthase
M6G44_05985	COG0494	nUDIX hydrolase
M6G44_05990	COG0217	transcriptional regulatory protein
M6G44_06000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M6G44_06005	COG0612	Peptidase, M16
M6G44_06015	COG0471	metal ion transport
M6G44_06020	COG0583	DNA-binding transcription factor activity
M6G44_06025	COG3266	domain, Protein
M6G44_06030	COG1187	pseudouridine synthase activity
M6G44_06035	COG0009	L-threonylcarbamoyladenylate synthase
M6G44_06045	COG2837	iron assimilation
M6G44_06050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M6G44_06055	COG0512	Glutamine amidotransferase of anthranilate synthase
M6G44_06065	COG2226	methyltransferase
M6G44_06070	COG2268	Band 7 protein
M6G44_06075	COG2841	Protein conserved in bacteria
M6G44_06090	COG2965	DNA replication, synthesis of RNA primer
M6G44_06105	COG3201	nicotinamide mononucleotide transporter
M6G44_06110	COG2976	Protein conserved in bacteria
M6G44_06120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M6G44_06125	COG1426	Protein conserved in bacteria
M6G44_06130	COG0659	secondary active sulfate transmembrane transporter activity
M6G44_06140	COG0673	inositol 2-dehydrogenase activity
M6G44_06145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M6G44_06145	COG0475	glutathione-regulated potassium exporter activity
M6G44_06170	COG2207	Transcriptional regulator
M6G44_06180	COG1902	pentaerythritol trinitrate reductase activity
M6G44_06190	COG2084	Dehydrogenase
M6G44_06195	COG0778	Nitroreductase
M6G44_06200	COG2095	MarC family integral membrane protein
M6G44_06215	COG0625	glutathione transferase activity
M6G44_06230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M6G44_06235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M6G44_06250	COG1275	C4-dicarboxylate transporter malic acid transport protein
M6G44_06255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M6G44_06265	COG1132	(ABC) transporter
M6G44_06270	COG1854	S-ribosylhomocysteine lyase activity
M6G44_06275	COG3008	intermembrane lipid transfer
M6G44_06280	COG0735	belongs to the Fur family
M6G44_06285	COG0716	FMN binding
M6G44_06295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M6G44_06300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M6G44_06305	COG2252	PERMEase
M6G44_06310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M6G44_06315	COG2081	HI0933 family
M6G44_06320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M6G44_06330	COG0560	Phosphoserine phosphatase
M6G44_06345	COG0058	SHG alpha-glucan phosphorylase activity
M6G44_06350	COG2909	trisaccharide binding
M6G44_06360	COG4580	involved in the transport of maltose and maltodextrins
M6G44_06365	COG3842	ATPase activity
M6G44_06380	COG3833	ABC-type maltose transport systems, permease component
M6G44_06385	COG1640	4-alpha-glucanotransferase
M6G44_06390	COG1966	Carbon starvation protein
M6G44_06395	COG0084	hydrolase, TatD family'
M6G44_06400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6G44_06410	COG0778	Nitroreductase
M6G44_06425	COG4172	Belongs to the ABC transporter superfamily
M6G44_06430	COG0191	fructose-bisphosphate aldolase activity
M6G44_06435	COG0126	phosphoglycerate kinase activity
M6G44_06440	COG0471	metal ion transport
M6G44_06445	COG0471	metal ion transport
M6G44_06450	COG0471	metal ion transport
M6G44_06455	COG0187	DNA topoisomerase II activity
M6G44_06460	COG5002	protein histidine kinase activity
M6G44_06465	COG0745	RESPONSE REGULATOR receiver
M6G44_06490	COG0789	Transcriptional regulator
M6G44_06510	COG0300	oxidoreductase activity
M6G44_06515	COG0778	Nitroreductase
M6G44_06520	COG0616	signal peptide processing
M6G44_06525	COG3719	Belongs to the RNase T2 family
M6G44_06535	COG1252	NADH dehydrogenase
M6G44_06540	COG2183	response to ionizing radiation
M6G44_06545	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_06550	COG3063	Type IV pilus biogenesis stability protein PilW
M6G44_06590	COG2161	toxin-antitoxin pair type II binding
M6G44_06595	COG4115	mRNA cleavage
M6G44_06600	COG2835	tetraacyldisaccharide 4'-kinase activity
M6G44_06610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M6G44_06620	COG2166	iron-sulfur cluster assembly
M6G44_06640	COG0488	(ABC) transporter
M6G44_06645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M6G44_06665	COG5007	Belongs to the BolA IbaG family
M6G44_06675	COG2854	intermembrane phospholipid transfer
M6G44_06680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M6G44_06685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M6G44_06690	COG1127	ABC transporter
M6G44_06695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6G44_06700	COG1090	epimerase
M6G44_06730	COG2814	Major facilitator Superfamily
M6G44_06760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M6G44_06770	COG1794	racemase activity, acting on amino acids and derivatives
M6G44_06775	COG2814	Major facilitator Superfamily
M6G44_06780	COG0363	glucosamine-6-phosphate deaminase activity
M6G44_06785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M6G44_06790	COG1218	3'(2'),5'-bisphosphate nucleotidase
M6G44_06795	COG0494	nUDIX hydrolase
M6G44_06800	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M6G44_06810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M6G44_06815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M6G44_06830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M6G44_06835	COG1178	ABC-type Fe3 transport system permease component
M6G44_06840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6G44_06845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M6G44_06850	COG2190	(PTS) system
M6G44_06855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M6G44_06860	COG0210	DNA helicase
M6G44_06865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M6G44_06870	COG0409	Hydrogenase expression formation protein
M6G44_06875	COG0309	Hydrogenase expression formation protein (HypE)
M6G44_06880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
M6G44_06885	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
M6G44_06890	COG0437	4 iron, 4 sulfur cluster binding
M6G44_06895	COG5557	Pfam Polysulphide reductase, NrfD
M6G44_06900	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
M6G44_06905	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M6G44_06910	COG1773	rubredoxin
M6G44_06915	COG0298	carbon dioxide binding
M6G44_06920	COG0375	protein maturation
M6G44_06955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M6G44_06960	COG0308	aminopeptidase N
M6G44_06965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M6G44_06970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M6G44_06975	COG0295	cytidine deaminase activity
M6G44_06980	COG2177	Part of the ABC transporter FtsEX involved in
M6G44_06985	COG2884	Cell division ATP-binding protein ftsE
M6G44_06990	COG0552	protein localization to endoplasmic reticulum
M6G44_06995	COG0742	ribosomal rna small subunit methyltransferase
M6G44_07000	COG3099	Belongs to the UPF0263 family
M6G44_07005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M6G44_07015	COG4160	amino acid transport
M6G44_07020	COG4215	(ABC) transporter
M6G44_07025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6G44_07030	COG1126	abc transporter atp-binding protein
M6G44_07035	COG1881	PFAM PEBP family protein
M6G44_07045	COG3620	sequence-specific DNA binding
M6G44_07055	COG4232	protein-disulfide reductase activity
M6G44_07060	COG3101	peptidyl-lysine hydroxylation
M6G44_07070	COG3107	peptidoglycan biosynthetic process
M6G44_07075	COG0792	nuclease activity
M6G44_07080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M6G44_07115	COG1138	Cytochrome C-type biogenesis protein
M6G44_07125	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6G44_07130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6G44_07135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6G44_07140	COG4133	protoheme IX ABC transporter activity
M6G44_07145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M6G44_07180	COG3630	sodium ion export across plasma membrane
M6G44_07190	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M6G44_07195	COG2824	Alkylphosphonate utilization operon protein PhnA
M6G44_07200	COG1858	cytochrome C peroxidase
M6G44_07210	COG0762	integral membrane protein
M6G44_07215	COG3171	Protein conserved in bacteria
M6G44_07220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M6G44_07225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M6G44_07230	COG0416	fatty acid biosynthetic process
M6G44_07235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M6G44_07240	COG1399	metal-binding, possibly nucleic acid-binding protein
M6G44_07245	COG4137	Cytochrome C assembly protein
M6G44_07250	COG4536	flavin adenine dinucleotide binding
M6G44_07255	COG0733	neurotransmitter:sodium symporter activity
M6G44_07265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6G44_07265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6G44_07270	COG3715	PTS system
M6G44_07275	COG3716	PTS system mannose fructose sorbose family IID component
M6G44_07310	COG1840	ABC-type Fe3 transport system, periplasmic component
M6G44_07325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M6G44_07340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M6G44_07345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M6G44_07350	COG0049	tRNA binding
M6G44_07355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M6G44_07360	COG0859	PFAM glycosyl transferase family 9
M6G44_07365	COG0859	PFAM glycosyl transferase family 9
M6G44_07375	COG3061	Opacity-associated protein A
M6G44_07375	COG3266	domain, Protein
M6G44_07380	COG1555	photosystem II stabilization
M6G44_07405	COG0732	type I restriction modification DNA specificity domain
M6G44_07410	COG4974	Belongs to the 'phage' integrase family
M6G44_07420	COG2918	glutathione biosynthetic process
M6G44_07420	COG1181	Belongs to the D-alanine--D-alanine ligase family
M6G44_07430	COG0814	amino acid
M6G44_07435	COG3691	Protein conserved in bacteria
M6G44_07440	COG4989	oxidoreductase activity
M6G44_07445	COG1022	Amp-dependent synthetase and ligase
M6G44_07470	COG4211	Belongs to the binding-protein-dependent transport system permease family
M6G44_07475	COG1129	ABC transporter
M6G44_07480	COG1879	ABC-type sugar transport system periplasmic component
M6G44_07490	COG0247	lactate metabolic process
M6G44_07490	COG0277	FAD linked oxidase domain protein
M6G44_07495	COG2050	protein possibly involved in aromatic compounds catabolism
M6G44_07505	COG3005	denitrification pathway
M6G44_07510	COG3043	anaerobic respiration
M6G44_07515	COG0348	domain, Protein
M6G44_07520	COG0437	4 iron, 4 sulfur cluster binding
M6G44_07525	COG0243	molybdopterin cofactor binding
M6G44_07535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M6G44_07540	COG2249	NAD(P)H dehydrogenase (quinone) activity
M6G44_07550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M6G44_07555	COG1803	Methylglyoxal synthase
M6G44_07560	COG1289	transmembrane transporter activity
M6G44_07575	COG0783	Belongs to the Dps family
M6G44_07600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M6G44_07605	COG0204	Acyl-transferase
M6G44_07615	COG0825	malonyl-CoA metabolic process
M6G44_07635	COG2801	Transposase and inactivated derivatives
M6G44_07645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M6G44_07645	COG0678	peroxiredoxin activity
M6G44_07650	COG0583	DNA-binding transcription factor activity
M6G44_07655	COG1309	transcriptional regulator
M6G44_07660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6G44_07665	COG0557	exoribonuclease II activity
M6G44_07670	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_07685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M6G44_07740	COG0305	Participates in initiation and elongation during chromosome replication
M6G44_07770	COG0741	lytic transglycosylase activity
M6G44_07775	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M6G44_07780	COG1194	a g-specific adenine glycosylase
M6G44_07785	COG0346	lactoylglutathione lyase activity
M6G44_07790	COG1489	DNA binding
M6G44_07795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M6G44_07800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M6G44_07820	COG1487	ribonuclease activity
M6G44_07840	COG0085	RNA polymerase activity
M6G44_07870	COG0222	ribosome binding
M6G44_07875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M6G44_07880	COG0081	regulation of translation
M6G44_07885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M6G44_07895	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M6G44_07910	COG1297	OPT oligopeptide transporter protein
M6G44_07915	COG0758	DNA mediated transformation
M6G44_07930	COG4783	chaperone-mediated protein folding
M6G44_07950	COG0545	Peptidyl-prolyl cis-trans isomerase
M6G44_07955	COG0235	Class ii aldolase
M6G44_07960	COG3623	hexulose-6-phosphate isomerase
M6G44_07985	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M6G44_08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6G44_08010	COG1126	abc transporter atp-binding protein
M6G44_08020	COG0765	amino acid transport
M6G44_08025	COG3477	response to acidic pH
M6G44_08030	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_08055	COG1119	ATPase activity
M6G44_08070	COG1739	Uncharacterized protein family UPF0029
M6G44_08075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6G44_08080	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
M6G44_08085	COG1970	mechanosensitive ion channel activity
M6G44_08090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M6G44_08095	COG0321	lipoyl(octanoyl) transferase activity
M6G44_08100	COG2921	Belongs to the UPF0250 family
M6G44_08105	COG1686	Belongs to the peptidase S11 family
M6G44_08110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M6G44_08115	COG0772	Belongs to the SEDS family
M6G44_08120	COG0768	penicillin binding
M6G44_08125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M6G44_08130	COG0799	negative regulation of ribosome biogenesis
M6G44_08140	COG1126	abc transporter atp-binding protein
M6G44_08145	COG0765	amino acid transport
M6G44_08150	COG3681	Belongs to the UPF0597 family
M6G44_08155	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M6G44_08165	COG3691	Protein conserved in bacteria
M6G44_08215	COG0831	urea catabolic process
M6G44_08225	COG1122	ATPase activity
M6G44_08230	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M6G44_08235	COG0310	cobalt ion transport
M6G44_08240	COG0310	cobalt ion transport
M6G44_08245	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
M6G44_08250	COG0583	DNA-binding transcription factor activity
M6G44_08260	COG0490	domain, Protein
M6G44_08260	COG0471	metal ion transport
M6G44_08265	COG3722	fumarate hydratase activity
M6G44_08280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M6G44_08285	COG1349	DNA-binding transcription factor activity
M6G44_08310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M6G44_08315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M6G44_08320	COG2900	Belongs to the SlyX family
M6G44_08325	COG0545	Peptidyl-prolyl cis-trans isomerase
M6G44_08330	COG2964	Protein conserved in bacteria
M6G44_08335	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M6G44_08345	COG2168	tRNA wobble position uridine thiolation
M6G44_08380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M6G44_08385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M6G44_08395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M6G44_08430	COG0561	phosphatase activity
M6G44_08435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6G44_08440	COG3012	SEC-C Motif Domain Protein
M6G44_08450	COG3716	PTS system mannose fructose sorbose family IID component
M6G44_08455	COG3715	PTS system
M6G44_08460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6G44_08460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6G44_08465	COG2610	gluconate transmembrane transporter activity
M6G44_08470	COG3265	gluconokinase activity
M6G44_08475	COG1609	Transcriptional regulator
M6G44_08495	COG1172	Belongs to the binding-protein-dependent transport system permease family
M6G44_08500	COG1879	ABC-type sugar transport system periplasmic component
M6G44_08505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M6G44_08510	COG0243	molybdopterin cofactor binding
M6G44_08515	COG0437	4 iron, 4 sulfur cluster binding
M6G44_08520	COG3302	dmso reductase anchor subunit
M6G44_08525	COG3381	protein complex oligomerization
M6G44_08530	COG2221	Nitrite and sulphite reductase 4Fe-4S
M6G44_08530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M6G44_08555	COG1349	DNA-binding transcription factor activity
M6G44_08560	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
M6G44_08565	COG1070	Carbohydrate kinase
M6G44_08570	COG4154	Belongs to the RbsD FucU family
M6G44_08575	COG0235	Class ii aldolase
M6G44_08580	COG0738	Major facilitator superfamily
M6G44_08585	COG1454	alcohol dehydrogenase
M6G44_08590	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_08600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M6G44_08630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M6G44_08660	COG1629	transport
M6G44_08660	COG4771	TonB-dependent receptor
M6G44_08680	COG0716	FMN binding
M6G44_08695	COG3276	selenocysteine insertion sequence binding
M6G44_08700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M6G44_08705	COG0569	domain protein
M6G44_08710	COG0268	Binds directly to 16S ribosomal RNA
M6G44_08715	COG0728	peptidoglycan biosynthetic process
M6G44_08735	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M6G44_08740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M6G44_08745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M6G44_08755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M6G44_08760	COG2244	polysaccharide biosynthetic process
M6G44_08765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M6G44_08785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M6G44_08840	COG4974	Belongs to the 'phage' integrase family
M6G44_08890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M6G44_08895	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M6G44_08900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M6G44_08905	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M6G44_08910	COG1053	succinate dehydrogenase
M6G44_08915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M6G44_08920	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M6G44_08925	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M6G44_08935	COG0019	diaminopimelate decarboxylase activity
M6G44_08940	COG0625	glutathione transferase activity
M6G44_08955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M6G44_08965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M6G44_08975	COG0521	Mo-molybdopterin cofactor biosynthetic process
M6G44_08990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6G44_09020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M6G44_09025	COG1045	serine acetyltransferase
M6G44_09030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M6G44_09040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6G44_09050	COG1652	LysM domain
M6G44_09055	COG2927	DNA polymerase III (CHI subunit)
M6G44_09060	COG2153	protein acetylation
M6G44_09090	COG1530	ribonuclease E activity
M6G44_09100	COG1755	Isoprenylcysteine carboxyl methyltransferase
M6G44_09110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M6G44_09120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M6G44_09125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M6G44_09150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6G44_09160	COG1720	tRNA m6t6A37 methyltransferase activity
M6G44_09165	COG4804	nuclease activity
M6G44_09170	COG1575	Belongs to the MenA family. Type 1 subfamily
M6G44_09180	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M6G44_09185	COG1088	dTDP-glucose 4,6-dehydratase activity
M6G44_09210	COG1215	transferase activity, transferring glycosyl groups
M6G44_09235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M6G44_09245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M6G44_09250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M6G44_09260	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_09265	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M6G44_09270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M6G44_09275	COG0737	Belongs to the 5'-nucleotidase family
M6G44_09285	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_09290	COG0606	chelatase, subunit chli
M6G44_09300	COG2267	carboxylic ester hydrolase activity
M6G44_09315	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M6G44_09325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6G44_09330	COG0363	glucosamine-6-phosphate deaminase activity
M6G44_09335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M6G44_09355	COG0051	transcription antitermination factor activity, RNA binding
M6G44_09360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M6G44_09365	COG0088	Forms part of the polypeptide exit tunnel
M6G44_09370	COG0089	rRNA binding
M6G44_09375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M6G44_09380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M6G44_09385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M6G44_09390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M6G44_09395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M6G44_09400	COG0255	Belongs to the universal ribosomal protein uL29 family
M6G44_09405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M6G44_09415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M6G44_09420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M6G44_09425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M6G44_09430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M6G44_09435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M6G44_09440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M6G44_09445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M6G44_09450	COG1841	ribosomal large subunit assembly
M6G44_09460	COG0201	protein transport
M6G44_09470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M6G44_09475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M6G44_09480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M6G44_09485	COG0202	RNA polymerase activity
M6G44_09495	COG0228	four-way junction DNA binding
M6G44_09500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M6G44_09505	COG0336	Belongs to the RNA methyltransferase TrmD family
M6G44_09510	COG0335	large ribosomal subunit rRNA binding
M6G44_09515	COG2850	peptidyl-arginine hydroxylation
M6G44_09520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6G44_09525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6G44_09570	COG2852	Protein conserved in bacteria
M6G44_09585	COG4106	trans-aconitate 2-methyltransferase activity
M6G44_09600	COG2832	Protein of unknown function (DUF454)
M6G44_09610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M6G44_09620	COG0084	hydrolase, TatD family'
M6G44_09635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M6G44_09645	COG0470	DNA polymerase III
M6G44_09650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M6G44_09655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M6G44_09675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6G44_09680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M6G44_09685	COG0254	rRNA binding
M6G44_09690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M6G44_09695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6G44_09700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M6G44_09705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M6G44_09715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M6G44_09740	COG1595	DNA-templated transcription, initiation
M6G44_09745	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M6G44_09755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M6G44_09780	COG2502	aspartate--ammonia ligase
M6G44_09785	COG1522	sequence-specific DNA binding
M6G44_09790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M6G44_09830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M6G44_09855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M6G44_09865	COG4208	sulfate ABC transporter
M6G44_09870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M6G44_09875	COG1304	FMN binding
M6G44_09880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M6G44_09880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M6G44_09885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M6G44_09895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M6G44_09900	COG2995	paraquat-inducible protein a
M6G44_09905	COG1305	Transglutaminase-like
M6G44_09915	COG2608	mercury ion transmembrane transporter activity
M6G44_09920	COG1979	alcohol dehydrogenase
M6G44_09925	COG0583	DNA-binding transcription factor activity
M6G44_09930	COG2171	N-acyltransferase activity
M6G44_09935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M6G44_09945	COG0511	ligase activity, forming carbon-carbon bonds
M6G44_09950	COG0439	Biotin carboxylase
M6G44_09960	COG3084	Protein conserved in bacteria
M6G44_09965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M6G44_09970	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M6G44_09970	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M6G44_09975	COG0742	ribosomal rna small subunit methyltransferase
M6G44_09980	COG1876	peptidase activity
M6G44_09985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6G44_09990	COG1393	Belongs to the ArsC family
M6G44_10000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M6G44_10005	COG0564	pseudouridine synthase activity
M6G44_10015	COG0668	transmembrane transport
M6G44_10020	COG0439	Biotin carboxylase
M6G44_10030	COG1025	Belongs to the peptidase M16 family
M6G44_10035	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M6G44_10060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M6G44_10065	COG1067	ATP-dependent peptidase activity
M6G44_10070	COG3120	sequence-specific DNA binding
M6G44_10075	COG0180	Tryptophanyl-tRNA synthetase
M6G44_10095	COG0730	response to heat
M6G44_10110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M6G44_10120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M6G44_10125	COG2116	formate transmembrane transporter activity
M6G44_10155	COG1070	Carbohydrate kinase
M6G44_10160	COG2115	Belongs to the xylose isomerase family
M6G44_10165	COG4213	ABC transporter substrate-binding protein
M6G44_10170	COG1129	ABC transporter
M6G44_10175	COG4214	carbohydrate transport
M6G44_10180	COG1609	Transcriptional regulator
M6G44_10180	COG2207	Transcriptional regulator
M6G44_10185	COG3590	peptidase
M6G44_10195	COG4145	pantothenate transmembrane transporter activity
M6G44_10200	COG3924	membrane
M6G44_10205	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
M6G44_10210	COG2853	Lipoprotein
M6G44_10215	COG0676	glucose-6-phosphate 1-epimerase activity
M6G44_10230	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_10240	COG0726	polysaccharide deacetylase
M6G44_10240	COG1649	PFAM Uncharacterised BCR, COG1649
M6G44_10245	COG1215	transferase activity, transferring glycosyl groups
M6G44_10255	COG0149	triose-phosphate isomerase activity
M6G44_10265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M6G44_10270	COG1238	metal cluster binding
M6G44_10285	COG1388	LysM domain
M6G44_10285	COG4942	peptidase
M6G44_10290	COG2818	Glycosylase
M6G44_10300	COG0700	Nucleoside recognition
M6G44_10305	COG3366	ferrous iron transmembrane transporter activity
M6G44_10315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M6G44_10320	COG0594	ribonuclease P activity
M6G44_10325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M6G44_10330	COG0174	glutamine synthetase
M6G44_10335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M6G44_10340	COG0494	nUDIX hydrolase
M6G44_10370	COG1490	D-aminoacyl-tRNA deacylase activity
M6G44_10375	COG1295	ribonuclease BN
M6G44_10400	COG2826	transposase and inactivated derivatives, IS30 family
M6G44_10420	COG1064	alcohol dehydrogenase
M6G44_10430	COG1923	regulation of RNA biosynthetic process
M6G44_10435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M6G44_10440	COG1611	Belongs to the LOG family
M6G44_10445	COG1694	Mazg nucleotide pyrophosphohydrolase
M6G44_10460	COG1309	transcriptional regulator
M6G44_10470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M6G44_10475	COG2003	Belongs to the UPF0758 family
M6G44_10480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M6G44_10485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M6G44_10495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M6G44_10500	COG0076	glutamate decarboxylase activity
M6G44_10505	COG0425	Belongs to the sulfur carrier protein TusA family
M6G44_10510	COG2391	methyltransferase activity
M6G44_10515	COG3085	chromosome segregation
M6G44_10535	COG0598	Magnesium transport protein CorA
M6G44_10540	COG2226	methyltransferase
M6G44_10555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M6G44_10560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M6G44_10565	COG0805	protein transport
M6G44_10585	COG1114	Component of the transport system for branched-chain amino acids
M6G44_10590	COG1028	Short-chain dehydrogenase reductase Sdr
M6G44_10595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M6G44_10600	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M6G44_10605	COG0142	geranyltranstransferase activity
M6G44_10615	COG0431	NADPH-dependent FMN reductase
M6G44_10715	COG4139	cobalamin transport
M6G44_10730	COG4774	siderophore transport
M6G44_10740	COG4774	siderophore transport
M6G44_10765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M6G44_10820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage