locus-tag class description CHY23_00002 ENOG4105D1F ATP-binding protein CHY23_00004 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CHY23_00005 ENOG4105EIN peptidylprolyl cis-trans isomerase CHY23_00006 ENOG4105EEQ Na H antiporter CHY23_00007 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CHY23_00008 ENOG4105CKW Inner membrane protein yedI CHY23_00009 ENOG410601J HemY protein CHY23_00010 ENOG4105ECF c-methyltransferase CHY23_00011 ENOG41076E6 Uroporphyrinogen-III Synthase CHY23_00012 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CHY23_00013 ENOG4108EKI Dehydrogenase CHY23_00016 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CHY23_00017 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CHY23_00018 ENOG4105D9N nucleoside CHY23_00019 ENOG4108VW9 Membrane CHY23_00020 ENOG4108UHU Aldolase CHY23_00021 ENOG4107SS6 2-dehydro-3-deoxygluconokinase CHY23_00022 ENOG4105D2H Uronic isomerase CHY23_00025 ENOG4107YCY Transcriptional regulator CHY23_00027 ENOG4105E0X reductase CHY23_00028 ENOG4108RYC glycosyltransferase CHY23_00029 ENOG4108RJ9 Glycosyl transferase, family 2 CHY23_00031 ENOG41068D6 Glycosyltransferase CHY23_00033 ENOG4108ZPC Polysaccharide pyruvyl transferase CHY23_00034 ENOG41080C8 DUF218 domain CHY23_00035 ENOG4105C25 Primosomal protein n' CHY23_00036 ENOG4105CQC Prephenate dehydratase CHY23_00037 ENOG4105DGW oligopeptidase A CHY23_00038 ENOG4105F1A Pyruvate formate-lyase CHY23_00039 ENOG4105C6N Formate acetyltransferase CHY23_00040 ENOG4105TMB Formate nitrite transporter CHY23_00041 ENOG4105W39 Membrane CHY23_00042 ENOG4105D0M Protease HtpX homolog CHY23_00043 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CHY23_00044 ENOG4105DWU Membrane CHY23_00045 ENOG4105E4F Isochorismate synthase CHY23_00046 ENOG4105CHM Aminotransferase CHY23_00047 ENOG4105DTR rard protein CHY23_00048 ENOG4105DTR rard protein CHY23_00049 ENOG4105N14 lysine exporter protein LysE YggA CHY23_00052 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related CHY23_00054 ENOG4108DMF Cytochrome C biogenesis protein CHY23_00055 ENOG4107QX9 Thiol disulfide interChange protein CHY23_00056 ENOG4105DA4 cytochrome c-type biogenesis protein CHY23_00057 ENOG4105CKD glutathione-regulated potassium-efflux system protein CHY23_00058 ENOG4107T0K Adenylate cyclase CHY23_00059 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CHY23_00060 ENOG4105IYK transposase CHY23_00061 ENOG4105DQ6 Transposase CHY23_00063 ENOG4105WXI Bacterial OB fold (BOF) protein CHY23_00066 ENOG4105XJC Two component transcriptional regulator (Winged helix family CHY23_00067 ENOG4105DHQ Histidine kinase CHY23_00068 ENOG4108UUE Transcriptional regulator CHY23_00069 ENOG4105VIE preprotein translocase, subunit YajC CHY23_00070 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CHY23_00071 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CHY23_00072 ENOG41090A1 ferritin CHY23_00073 ENOG41090A1 ferritin CHY23_00074 ENOG4105C7N Xanthine uracil vitamin C permease CHY23_00075 ENOG4108Z03 MAF-like protein CHY23_00077 ENOG4105HEI LysR family (Transcriptional regulator CHY23_00080 ENOG4105E4P ATPase (AAA CHY23_00083 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CHY23_00084 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CHY23_00085 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CHY23_00086 ENOG4105EPW hflc protein CHY23_00087 ENOG4107QJR hflk protein CHY23_00088 ENOG4105K63 Thioredoxin CHY23_00090 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CHY23_00092 ENOG4105D5Q Arginine ornithine antiporter CHY23_00093 ENOG4105D5Q Arginine ornithine antiporter CHY23_00095 ENOG4105CWC Acetylornithine deacetylase CHY23_00096 ENOG4105EIF outer membrane protein W CHY23_00097 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CHY23_00098 ENOG4105D6J arsenicaL-resistance protein CHY23_00099 ENOG4105K89 arsenate reductase CHY23_00101 ENOG4108IJ0 Aspartate ammonia-lyase CHY23_00103 ENOG4105CXB phosphoribosylaminoimidazole synthetase CHY23_00104 ENOG41069UX Beta-N-acetyl-hexosaminidase CHY23_00106 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CHY23_00107 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CHY23_00112 ENOG4108M8S permease YjgP YjgQ family protein CHY23_00113 ENOG4108K5H permease YjgP YjgQ family protein CHY23_00114 ENOG4105C0B DNA polymerase III (alpha subunit) CHY23_00115 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CHY23_00116 ENOG4105E55 glycerol-3-phosphate acyltransferase CHY23_00117 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CHY23_00118 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) CHY23_00119 ENOG4105EE5 Membrane protein terC CHY23_00120 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CHY23_00121 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) CHY23_00122 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CHY23_00124 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) CHY23_00125 ENOG4105C9U ATP-dependent DNA helicase RecQ CHY23_00126 ENOG4105XQ6 frataxin-like protein CHY23_00127 ENOG4107J0A lipopolysaccharide biosynthetic process CHY23_00128 ENOG4107J0A lipopolysaccharide biosynthetic process CHY23_00129 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CHY23_00130 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CHY23_00131 ENOG4105C34 Pseudouridine synthase CHY23_00132 ENOG4108VTV Inherit from NOG: Membrane CHY23_00133 ENOG4105CTQ phosphohexokinase CHY23_00134 ENOG4105C9B Cysteine desulfurase CHY23_00135 ENOG4105KK6 nuclease CHY23_00136 ENOG4105BZG amino acid carrier protein CHY23_00137 ENOG4105DSF transport protein CHY23_00139 ENOG4105CFP Peptidase U32 CHY23_00140 ENOG4105PF3 O-Antigen polymerase CHY23_00141 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CHY23_00143 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CHY23_00144 ENOG4105K8N protein family UPF0079, ATPase CHY23_00145 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CHY23_00146 ENOG4107QP8 phosphohexose isomerase CHY23_00147 ENOG4105W0Z cytoplasmic protein CHY23_00152 ENOG4105E2X shikimate dehydrogenase CHY23_00154 ENOG4108WI1 Dna topoisomerase CHY23_00155 ENOG41060QA UPF0267 protein CHY23_00156 ENOG4105Y3E Modulates RecA activity (By similarity) CHY23_00157 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CHY23_00159 ENOG4105CRQ synthase (Component I) CHY23_00160 ENOG4105CGY Dna recombination protein CHY23_00161 ENOG4105DDQ anthranilate synthase CHY23_00163 ENOG4105C9M aspartyl-trna synthetase CHY23_00164 ENOG4108TIT dATP pyrophosphohydrolase CHY23_00167 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CHY23_00168 ENOG4107RAN Peptidase, M16 CHY23_00170 ENOG4107QPK )-transporter CHY23_00171 ENOG4105DZ2 Transcriptional regulator CHY23_00172 ENOG4106ZV1 Transferrin binding protein-like solute binding protein CHY23_00174 ENOG4105FE9 pseudouridine synthase CHY23_00175 ENOG4107RTD sua5 ycio yrdc ywlc family protein CHY23_00178 ENOG4105EZR dyp-type peroxidase family protein CHY23_00179 ENOG4105CRQ synthase (Component I) CHY23_00180 ENOG4105DDQ anthranilate synthase CHY23_00182 ENOG4105DMQ Methyltransferase CHY23_00183 ENOG4105RHG CHY23_00184 ENOG4105Z2P Protein of unknown function (DUF465) CHY23_00188 ENOG4105C12 Phosphoribosylglycinamide synthetase CHY23_00190 ENOG4105N21 Membrane CHY23_00192 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CHY23_00193 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CHY23_00194 ENOG4105CHH sulfate transporter CHY23_00196 ENOG4105D9R oxidoreductase CHY23_00197 ENOG4105CKD glutathione-regulated potassium-efflux system protein CHY23_00200 ENOG4105EXG Transcriptional regulator CHY23_00206 ENOG4108ZHJ Organic hydroperoxide resistance protein CHY23_00212 ENOG4105CF7 AraC family transcriptional regulator CHY23_00214 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CHY23_00215 ENOG4105DEN Luciferase family CHY23_00216 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CHY23_00217 ENOG4108RCM Nitroreductase CHY23_00218 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CHY23_00220 ENOG4105C4W S-formylglutathione hydrolase CHY23_00225 ENOG4105C94 Transporter CHY23_00228 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein CHY23_00229 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 CHY23_00232 ENOG4105BZ1 (ABC) transporter CHY23_00233 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CHY23_00234 ENOG4105DY2 Paraquat-inducible protein b CHY23_00235 ENOG41090R7 Ferric uptake CHY23_00236 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) CHY23_00237 ENOG4105NNH LexA regulated protein CHY23_00238 ENOG4108Z66 YbaK ebsC protein CHY23_00239 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CHY23_00240 ENOG4105C7N Xanthine uracil vitamin C permease CHY23_00241 ENOG41090EX DsrE family CHY23_00242 ENOG4105CBX hi0933 family CHY23_00243 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CHY23_00244 ENOG41062Z9 Membrane CHY23_00245 ENOG4105EAC phosphoserine phosphatase CHY23_00248 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CHY23_00249 ENOG41061ZR Transcriptional regulator CHY23_00250 ENOG4107W52 maltose operon periplasmic protein CHY23_00251 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CHY23_00252 ENOG4108IJ9 (ABC) transporter CHY23_00253 ENOG4107FKK extracellular solute-binding protein family 1 CHY23_00254 ENOG4105D56 permease protein CHY23_00255 ENOG4105EG2 ABC transporter, permease CHY23_00256 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CHY23_00258 ENOG4105EYA deoxyribonuclease CHY23_00259 ENOG4105DC8 reductase CHY23_00260 ENOG4108TEB UPF0114 protein CHY23_00261 ENOG4108TVJ Nitroreductase CHY23_00265 ENOG4105D2N Aldolase CHY23_00266 ENOG4105BZA Phosphoglycerate kinase CHY23_00267 ENOG4105C8P )-transporter CHY23_00268 ENOG4105C8P )-transporter CHY23_00269 ENOG4105C8P )-transporter CHY23_00270 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CHY23_00271 ENOG4105BZU Histidine kinase CHY23_00272 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CHY23_00273 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CHY23_00274 ENOG4105E2Z phosphate ABC transporter (Permease CHY23_00275 ENOG4105E2Z phosphate ABC transporter (Permease CHY23_00276 ENOG4105C8U phosphate abc transporter CHY23_00277 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CHY23_00278 ENOG4108Z6Z Transcriptional regulator CHY23_00281 ENOG4105C59 p-type ATPase CHY23_00282 ENOG4105E1F short-chain dehydrogenase reductase CHY23_00283 ENOG41069NU Nitroreductase CHY23_00284 ENOG4105D07 Signal peptide peptidase, SppA CHY23_00285 ENOG41083KI ribonuclease, T2 CHY23_00286 ENOG4105GPY SprT protein CHY23_00287 ENOG4105CEP NADH dehydrogenase CHY23_00288 ENOG4105BZM domain protein CHY23_00289 ENOG41090FY type IV pilus biogenesis stability protein PilW CHY23_00290 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CHY23_00297 ENOG4105VTW prevent-host-death family CHY23_00298 ENOG4105KRQ Addiction module toxin, Txe YoeB family CHY23_00299 ENOG4105W49 UPF0434 protein CHY23_00301 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CHY23_00302 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CHY23_00303 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CHY23_00306 ENOG4108JDX DNA polymerase iii, epsilon subunit CHY23_00307 ENOG4105C5H ABC transporter CHY23_00311 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CHY23_00312 ENOG4105VFK BolA family CHY23_00314 ENOG4105E3I toluene tolerance CHY23_00315 ENOG4107PE3 Mammalian cell entry related domain protein CHY23_00316 ENOG4105CY3 ABC transporter, permease CHY23_00317 ENOG4105DHJ ABC, transporter CHY23_00318 ENOG4105C0H protease CHY23_00319 ENOG4105ECP epimerase CHY23_00323 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CHY23_00325 ENOG4105EYM Major Facilitator superfamily CHY23_00326 ENOG4105CMR udp-glucose 4-epimerase CHY23_00331 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CHY23_00333 ENOG4105DFS Conserved Protein CHY23_00335 ENOG4105D2S major facilitator superfamily CHY23_00336 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) CHY23_00337 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CHY23_00338 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CHY23_00339 ENOG4107RK2 ADP-ribose diphosphatase NudE CHY23_00340 ENOG4105VEJ Heat shock protein CHY23_00341 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CHY23_00342 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CHY23_00344 ENOG4105DBV ornithine carbamoyltransferase CHY23_00345 ENOG4105C5B carbamate kinase CHY23_00346 ENOG4105C5Y PTS System CHY23_00347 ENOG4107T0D ABC, transporter CHY23_00348 ENOG4106SMU thiamine transporter membrane protein CHY23_00349 ENOG4105KZ7 phosphocarrier protein hpr CHY23_00350 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CHY23_00351 ENOG4105C5Y PTS System CHY23_00353 ENOG4105C4R Atp-dependent dna helicase CHY23_00354 ENOG4107RSS Hydrogenase accessory protein HypB CHY23_00355 ENOG4105CQS hydrogenase expression formation protein HypD CHY23_00356 ENOG4105C45 hydrogenase expression formation protein (HypE) CHY23_00357 ENOG4105C8H hydrogenase maturation protein Hypf CHY23_00358 ENOG4105E3S small subunit CHY23_00359 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CHY23_00360 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit CHY23_00361 ENOG4105DPX Hydrogenase, large subunit CHY23_00362 ENOG4108USZ hydrogenase CHY23_00363 ENOG4108WGS hydrogenase 2-specific chaperone CHY23_00372 ENOG4108JA2 transcriptioN-repair coupling factor CHY23_00373 ENOG4105CD8 aminopeptidase N CHY23_00374 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CHY23_00375 ENOG4107ZVW dihydroneopterin aldolase CHY23_00376 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) CHY23_00377 ENOG4105CRP Part of the ABC transporter FtsEX involved in CHY23_00378 ENOG4105CAK Cell division ATP-binding protein ftsE CHY23_00379 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CHY23_00380 ENOG4106H78 methyltransferase CHY23_00381 ENOG4105XW2 UPF0263 protein CHY23_00382 ENOG4107UWN reductase CHY23_00384 ENOG4105DMR ABC, transporter CHY23_00385 ENOG4105GBT ABC transporter CHY23_00386 ENOG4106PMH Extracellular solute-binding protein family 3 CHY23_00387 ENOG4105E5Z arginine transporter ATP-binding subunit CHY23_00388 ENOG4108V1U phospholipid-binding protein CHY23_00390 ENOG4105KDP XRE family CHY23_00392 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CHY23_00393 ENOG4108BPE -transporting atpase CHY23_00394 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CHY23_00395 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) CHY23_00396 ENOG41082RQ UPF0102 protein CHY23_00397 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CHY23_00398 ENOG4105W4M Transport-associated protein CHY23_00404 ENOG4105DA4 cytochrome c-type biogenesis protein CHY23_00406 ENOG4105X3C heme exporter protein CHY23_00407 ENOG41060IM Heme exporter protein CHY23_00408 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CHY23_00409 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) CHY23_00410 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) CHY23_00417 ENOG4107QSA Oxaloacetate decarboxylase CHY23_00418 ENOG4105D9Q decarboxylase (Beta subunit) CHY23_00419 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CHY23_00420 ENOG4105CA0 peroxidase CHY23_00421 ENOG4105VZ9 UPF0235 protein CHY23_00422 ENOG4108VIA integral membrane protein CHY23_00423 ENOG41090ED Protein with unknown function (DUF469) CHY23_00424 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CHY23_00425 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CHY23_00426 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CHY23_00427 ENOG4105VGS 50s ribosomal protein l32 CHY23_00428 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CHY23_00429 ENOG4106KVJ cytochrome C assembly protein CHY23_00430 ENOG4108JU6 CBS domain protein CHY23_00431 ENOG4105C8J )-transporter CHY23_00433 ENOG4108EQA pts system CHY23_00434 ENOG4105ETZ PTS System CHY23_00435 ENOG4105F3R pts system mannose fructose sorbose family iid CHY23_00436 ENOG4108NK4 UPF0266 membrane protein CHY23_00437 ENOG4105EIP mannose-6-phosphate isomerase CHY23_00439 ENOG4105C42 Type I secretion membrane fusion protein (HlyD CHY23_00440 ENOG4108JJA ABC, transporter CHY23_00441 ENOG4107V48 Hemolysin-type calcium-binding CHY23_00442 ENOG41090Q8 at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP CHY23_00443 ENOG4105C4Y ABC transporter CHY23_00444 ENOG4107RCV ABC transporter, permease CHY23_00445 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CHY23_00446 ENOG4105DFU Cell wall formation (By similarity) CHY23_00449 ENOG4105EHV domain protein CHY23_00450 ENOG4105C5Q Transcriptional regulator CHY23_00451 ENOG4105EJ2 Transcriptional regulator CHY23_00452 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CHY23_00453 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CHY23_00455 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CHY23_00456 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CHY23_00457 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CHY23_00458 ENOG4105VCC 30S ribosomal protein S21 CHY23_00459 ENOG4105D3Q Sugar transferase CHY23_00460 ENOG4108KBE Glycosyl transferase, family 2 CHY23_00461 ENOG4105H63 Glycosyl transferase, family 2 CHY23_00466 ENOG4105EY8 ABC transporter CHY23_00467 ENOG4105MFV ABC-2 type transporter CHY23_00468 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CHY23_00470 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CHY23_00471 ENOG4105C1B dTDP-glucose 4-6-dehydratase CHY23_00472 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CHY23_00473 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CHY23_00474 ENOG4108R96 Methyltransferase, YaeB family CHY23_00476 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CHY23_00478 ENOG4108YZY peptidylprolyl cis-trans isomerase CHY23_00479 ENOG4105C7B Threonine dehydratase CHY23_00480 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CHY23_00481 ENOG4105E66 phosphoriboisomerase A CHY23_00482 ENOG4108JQ1 Dehydrogenase CHY23_00484 ENOG4105NXV High-affinity zinc uptake system protein CHY23_00486 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase CHY23_00488 ENOG4105C03 ribonuclease CHY23_00490 ENOG4105IYK transposase CHY23_00491 ENOG4105DQ6 Transposase CHY23_00492 ENOG4105DYS nad(p)h dehydrogenase (quinone) CHY23_00495 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CHY23_00496 ENOG4108BGM Quinol dehydrogenase periplasmic component CHY23_00497 ENOG4105GXZ Ferredoxin-type protein NapH CHY23_00498 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) CHY23_00499 ENOG4105CUW cytochrome C-TYPE protein CHY23_00501 ENOG4105KA0 thioesterase Superfamily protein CHY23_00502 ENOG4105CQB FAD linked oxidase domain protein CHY23_00503 ENOG4105W44 ompa motb domain protein CHY23_00504 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator CHY23_00505 ENOG4105C2J ABC transporter CHY23_00506 ENOG4108HWV )-transporter CHY23_00511 ENOG4108IQE Amp-dependent synthetase and ligase CHY23_00512 ENOG4107QM2 Aldo Keto reductase CHY23_00513 ENOG4105KZW UPF0381 protein CHY23_00514 ENOG4105CIC tryptophan-specific transport protein CHY23_00516 ENOG4105D9M gamma-glutamylcysteine synthetase CHY23_00518 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CHY23_00519 ENOG4107QTH restriction modification system DNA specificity domain CHY23_00524 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CHY23_00525 ENOG4108UBT opacity-associated protein CHY23_00527 ENOG4105XA0 heptosyltransferase ii CHY23_00528 ENOG4105D16 lipopolysaccharide heptosyltransferase i CHY23_00529 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CHY23_00530 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CHY23_00531 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CHY23_00532 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CHY23_00537 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CHY23_00539 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase CHY23_00540 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CHY23_00543 ENOG4105VUC UPF0237 protein CHY23_00544 ENOG4105C2I pirin domain protein CHY23_00545 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CHY23_00548 ENOG4105EM2 membrane CHY23_00549 ENOG4108Z5K methylglyoxal synthase CHY23_00550 ENOG4105D98 threonine synthase CHY23_00551 ENOG4105IYK transposase CHY23_00552 ENOG4105DQ6 Transposase CHY23_00553 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CHY23_00556 ENOG4107YB6 acetyltransferase, (GNAT) family CHY23_00557 ENOG4105MYG DNA polymerase iii, chi subunit CHY23_00558 ENOG4108WZM domain protein CHY23_00560 ENOG4107YZP Rhodanese domain protein CHY23_00561 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) CHY23_00562 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CHY23_00563 ENOG4105D7W serine acetyltransferase CHY23_00564 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CHY23_00569 ENOG4105CS9 pantothenic acid kinase CHY23_00570 ENOG4107QX9 Thiol disulfide interChange protein CHY23_00571 ENOG4108M1T Cytochrome c-type biogenesis protein CHY23_00572 ENOG4108M1T Cytochrome c-type biogenesis protein CHY23_00573 ENOG4108RIR Molybdenum cofactor biosynthesis protein CHY23_00574 ENOG4108YZA Nitrogen regulatory protein pii CHY23_00575 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CHY23_00576 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CHY23_00577 ENOG410863D Flavinator of succinate dehydrogenase CHY23_00579 ENOG4105D4P Coproporphyrinogen iii oxidase CHY23_00580 ENOG4108K3A Glutathione S-transferase CHY23_00581 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CHY23_00583 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CHY23_00584 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CHY23_00585 ENOG4105E33 succinate dehydrogenase CHY23_00586 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CHY23_00587 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CHY23_00588 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CHY23_00589 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CHY23_00594 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CHY23_00595 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CHY23_00596 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CHY23_00599 ENOG4105D1U peptidase U62 modulator of DNA gyrase CHY23_00600 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CHY23_00602 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CHY23_00614 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family CHY23_00615 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) CHY23_00617 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CHY23_00618 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CHY23_00619 ENOG4105EGZ biosynthesis protein CHY23_00620 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CHY23_00622 ENOG4108IJ1 Dehydrogenase CHY23_00623 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CHY23_00626 ENOG4105ESV Glycosyl transferase, family 4 CHY23_00629 ENOG4105CJR Integral membrane protein (MviN CHY23_00630 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CHY23_00631 ENOG4105C1A potassium transporter peripheral membrane CHY23_00632 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CHY23_00633 ENOG4105EM7 Selenocysteine-specific translation elongation factor CHY23_00636 ENOG4105QTB Flavodoxin CHY23_00638 ENOG4105CMG Carbohydrate kinase CHY23_00639 ENOG4108MVK Receptor CHY23_00641 ENOG4105M8F Biopolymer transport protein exbD tolR CHY23_00644 ENOG4105DWU Membrane CHY23_00645 ENOG4105DG4 malate L-lactate dehydrogenase CHY23_00646 ENOG4105MJ9 esterase CHY23_00647 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CHY23_00652 ENOG4107VDP teichoic acid biosynthesis CHY23_00658 ENOG4105DKW ABC transporter CHY23_00659 ENOG4105DKW ABC transporter CHY23_00662 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CHY23_00663 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CHY23_00664 ENOG4108RR8 protoporphyrinogen oxidase CHY23_00665 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CHY23_00666 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CHY23_00667 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CHY23_00669 ENOG4105DZ1 carboxypeptidase CHY23_00671 ENOG4105CNI cell division protein FtsW CHY23_00672 ENOG4105CJN penicillin-binding protein CHY23_00673 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CHY23_00674 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CHY23_00676 ENOG4105CDA abc transporter atp-binding protein CHY23_00677 ENOG4105E5Q amino acid AbC transporter CHY23_00678 ENOG4105CEM UPF0597 protein CHY23_00679 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CHY23_00680 ENOG410814C multidrug resistance protein CHY23_00681 ENOG4105KZW UPF0381 protein CHY23_00685 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CHY23_00686 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CHY23_00687 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CHY23_00689 ENOG4105CQM Urea amidohydrolase subunit alpha CHY23_00691 ENOG4108YZ9 Urea amidohydrolase subunit gamma CHY23_00693 ENOG4108JJB ABC transporter CHY23_00695 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein CHY23_00696 ENOG4108A51 CHY23_00697 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component CHY23_00698 ENOG4108M0I Transcriptional regulator CHY23_00700 ENOG4107QWE )-transporter CHY23_00701 ENOG4105E61 Mannitol repressor protein CHY23_00703 ENOG4105CTS PTS system mannitol-specific CHY23_00704 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CHY23_00705 ENOG410804X Transcriptional regulator CHY23_00708 ENOG4106YJS accessory processing protein CHY23_00710 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CHY23_00712 ENOG4105VRX Protein slyX homolog CHY23_00713 ENOG4108V1T peptidylprolyl cis-trans isomerase CHY23_00714 ENOG4105WWK YheO domain protein CHY23_00715 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CHY23_00716 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CHY23_00723 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CHY23_00724 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CHY23_00725 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CHY23_00726 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CHY23_00728 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CHY23_00731 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CHY23_00732 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CHY23_00733 ENOG410667J hydrolase CHY23_00734 ENOG4105EAB amino acid AbC transporter CHY23_00735 ENOG4105K5B UPF0225 protein CHY23_00737 ENOG4105F3R pts system mannose fructose sorbose family iid CHY23_00738 ENOG4105ETZ PTS System CHY23_00739 ENOG4108EQA pts system CHY23_00740 ENOG4105C6Z Gluconate CHY23_00741 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CHY23_00742 ENOG4105DIQ Transcriptional regulator CHY23_00743 ENOG4105ETE Transcriptional regulator (LacI family CHY23_00746 ENOG4105CNN ABC, transporter CHY23_00747 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CHY23_00748 ENOG4108RVA ribokinase CHY23_00749 ENOG4107QY8 reductase CHY23_00750 ENOG4105QAX Iron-sulfur CHY23_00751 ENOG4107KGK dmso reductase anchor subunit CHY23_00752 ENOG4108NEM leader-binding protein dmsD CHY23_00753 ENOG4105N1P Ferredoxin-type protein CHY23_00757 ENOG4108ETH Formylglycinamide ribotide synthetase CHY23_00758 ENOG4107EDW L-fucose operon activator CHY23_00759 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) CHY23_00760 ENOG4105CMG Carbohydrate kinase CHY23_00761 ENOG4105CMG Carbohydrate kinase CHY23_00762 ENOG4105NWF RbsD or FucU transport CHY23_00763 ENOG4107W7X Aldolase CHY23_00764 ENOG4105EDR glucose galactose transporter CHY23_00765 ENOG4105C0A alcohol dehydrogenase CHY23_00766 ENOG4105R3P Inner membrane protein yagU CHY23_00767 ENOG4105E5Q amino acid AbC transporter CHY23_00769 ENOG4105CDA abc transporter atp-binding protein CHY23_00770 ENOG4105CT1 (ABC) transporter CHY23_00771 ENOG4105E12 capsule polysaccharide CHY23_00779 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase CHY23_00780 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CHY23_00781 ENOG4108V1T peptidylprolyl cis-trans isomerase CHY23_00786 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CHY23_00788 ENOG4105C79 DNA protecting protein DprA CHY23_00789 ENOG4105EPD Oligopeptide transporter, Opt family CHY23_00792 ENOG4105PM1 preprotein translocase subunit SecE CHY23_00793 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CHY23_00794 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CHY23_00795 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CHY23_00796 ENOG4108VZM 50s ribosomal protein L10 CHY23_00797 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CHY23_00813 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CHY23_00814 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CHY23_00816 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CHY23_00817 ENOG4105CEN a g-specific adenine glycosylase CHY23_00818 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) CHY23_00819 ENOG4105E4C Lytic transglycosylase catalytic CHY23_00824 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CHY23_00825 ENOG4105CGH 5'-nucleotidase CHY23_00826 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CHY23_00827 ENOG4105YES addiction module antidote protein CHY23_00828 ENOG4105C0P Mg chelatase subunit ChlI CHY23_00829 ENOG4106IIQ Outer membrane lipoprotein CHY23_00830 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CHY23_00831 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CHY23_00833 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CHY23_00834 ENOG4105EVU fructokinase CHY23_00835 ENOG4108MB0 N-acetylneuraminate lyase CHY23_00836 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CHY23_00837 ENOG4105CE4 GlcNAc 6-P deacetylase CHY23_00838 ENOG4105C9Q fumarate hydratase class II CHY23_00841 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CHY23_00842 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CHY23_00843 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CHY23_00844 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CHY23_00845 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CHY23_00846 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CHY23_00847 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CHY23_00848 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CHY23_00849 ENOG41083MP 50s ribosomal protein l29 CHY23_00850 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CHY23_00852 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CHY23_00853 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CHY23_00854 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CHY23_00855 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CHY23_00856 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CHY23_00857 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CHY23_00858 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CHY23_00859 ENOG4105VPB 50S ribosomal protein L30 CHY23_00860 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CHY23_00861 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CHY23_00863 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CHY23_00864 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CHY23_00865 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CHY23_00866 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CHY23_00868 ENOG4105K5M 30s ribosomal protein S16 CHY23_00869 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CHY23_00870 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CHY23_00871 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CHY23_00872 ENOG4105EZE Cupin 4 family protein CHY23_00873 ENOG4105S10 periplasmic binding protein CHY23_00874 ENOG4105EHG Permease protein CHY23_00875 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CHY23_00880 ENOG4108J2R molybdopterin oxidoreductase CHY23_00883 ENOG4105WDY DNA (cytosine-5-)-methyltransferase CHY23_00888 ENOG4105WD1 Membrane CHY23_00889 ENOG4105K64 Glycosyl transferase, family 2 CHY23_00890 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CHY23_00891 ENOG4105RX8 Protein of unknown function (DUF1523) CHY23_00892 ENOG4105F8V Hydrolase, tatD family CHY23_00895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CHY23_00896 ENOG4105DJY efflux transporter, rnd family, mfp subunit CHY23_00897 ENOG4107ZJM MltA-interacting protein MipA CHY23_00898 ENOG4107QRG dna polymerase iii CHY23_00899 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CHY23_00900 ENOG4105HHA aminodeoxychorismate lyase CHY23_00904 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CHY23_00905 ENOG4105DJV ribulose-phosphate 3-epimerase CHY23_00906 ENOG4105NRA 50s ribosomal protein l31 type b CHY23_00907 ENOG4105YK5 50S ribosomal protein L36 CHY23_00908 ENOG4105BZ4 penicillin-binding protein CHY23_00909 ENOG4108IPT Naphthoate synthase CHY23_00910 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CHY23_00912 ENOG4105CB5 ATP-dependent DNA helicase recG CHY23_00915 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CHY23_00917 ENOG4108WQI RNA Polymerase CHY23_00918 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) CHY23_00919 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CHY23_00920 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CHY23_00921 ENOG4105CXY transporter CHY23_00923 ENOG4105DFP Integrase CHY23_00926 ENOG4105RQF LysR family Transcriptional regulator CHY23_00927 ENOG4105D6U Sodium Glutamate Symporter CHY23_00930 ENOG4108ZHR arsR family transcriptional regulator CHY23_00936 ENOG4105D5K Hemolysin activator protein CHY23_00937 ENOG4105CKT filamentous hemagglutinin CHY23_00937 ENOG4105CKT filamentous hemagglutinin CHY23_00941 ENOG410679B prophage CP4-57 regulatory protein alpA CHY23_00944 ENOG4105CU9 asparagine synthetase A CHY23_00945 ENOG4108VVK transcriptional Regulator, AsnC CHY23_00946 ENOG4108I5U Uridine phosphorylase CHY23_00947 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) CHY23_00954 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CHY23_00955 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CHY23_00960 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CHY23_00961 ENOG4108I5D sulfate abc transporter CHY23_00962 ENOG4105ECW sulfate abc transporter CHY23_00963 ENOG4108IJ6 ABC transporter CHY23_00965 ENOG4105DMF Dehydrogenase CHY23_00966 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CHY23_00967 ENOG4105D4A Cell wall formation (By similarity) CHY23_00969 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CHY23_00970 ENOG4105H2K paraquat-inducible protein a CHY23_00971 ENOG4108KS2 transglutaminase domain protein CHY23_00973 ENOG410681U heavy metal transport detoxification protein CHY23_00974 ENOG4107QW4 alcohol dehydrogenase CHY23_00975 ENOG4105EMY transcriptional regulator CHY23_00976 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CHY23_00977 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CHY23_00978 ENOG4108ST3 glycosyltransferase CHY23_00979 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CHY23_00980 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CHY23_00981 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CHY23_00983 ENOG4108Z33 Thiol disulfide Interchange Protein CHY23_00985 ENOG41063M6 Cell Division Protein CHY23_00985 ENOG41063M6 Cell Division Protein CHY23_00988 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CHY23_00989 ENOG4105KUZ arsenate reductase CHY23_00991 ENOG4105EEI dihydropteroate synthase CHY23_00992 ENOG4105EI2 Pseudouridine synthase CHY23_00995 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CHY23_00997 ENOG4107QXK peptidase CHY23_00998 ENOG4105DSY exodeoxyribonuclease V, gamma CHY23_01003 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CHY23_01004 ENOG4105DAN ATP-dependent protease CHY23_01005 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) CHY23_01006 ENOG4105C31 Tryptophanyl-tRNA synthetase CHY23_01010 ENOG4105HF0 Membrane CHY23_01013 ENOG4105F0N pyrophosphate phospho-hydrolase CHY23_01015 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CHY23_01016 ENOG4105TMB Formate nitrite transporter CHY23_01018 ENOG4105DQ6 Transposase CHY23_01019 ENOG4105DQ6 Transposase CHY23_01020 ENOG4105IYK transposase CHY23_01023 ENOG4105CFG Acts as a chaperone (By similarity) CHY23_01024 ENOG4105CMG Carbohydrate kinase CHY23_01025 ENOG4105C93 Xylose Isomerase CHY23_01026 ENOG4105DFW ABC transporter CHY23_01027 ENOG4105C2J ABC transporter CHY23_01028 ENOG4108HWW ABC transporter CHY23_01029 ENOG4105T16 Transcriptional regulator (AraC family) CHY23_01030 ENOG4105C9K Endothelin-converting enzyme 1 CHY23_01032 ENOG4108IA2 Sodium pantothenate symporter CHY23_01033 ENOG4105RG0 Membrane CHY23_01034 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) CHY23_01035 ENOG410903C (LipO)protein CHY23_01036 ENOG4105DSB aldose 1-epimerase CHY23_01039 ENOG4107BJW polysaccharide deacetylase CHY23_01040 ENOG4105CND Glycosyl transferase, family 2 CHY23_01042 ENOG4105CP7 Triose-phosphate isomerase CHY23_01043 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) CHY23_01044 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CHY23_01045 ENOG4108UM1 dedA family CHY23_01048 ENOG4108K5P (LipO)protein CHY23_01049 ENOG4108R3E Dna-3-methyladenine glycosylase i CHY23_01051 ENOG4108P2H Inner membrane protein YjiG CHY23_01052 ENOG41074DU domain protein CHY23_01053 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CHY23_01054 ENOG4105VG0 50S ribosomal protein l34 CHY23_01055 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CHY23_01056 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CHY23_01057 ENOG4105C5F glutamine synthetase CHY23_01058 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CHY23_01059 ENOG41087AY ADP-Ribose pyrophosphatase CHY23_01060 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CHY23_01061 ENOG4105W8Z 4'-phosphopantetheinyl transferase CHY23_01065 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CHY23_01066 ENOG4107S2Z UPF0761 membrane protein CHY23_01067 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CHY23_01076 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CHY23_01077 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CHY23_01078 ENOG4108URH decarboxylase CHY23_01079 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain CHY23_01080 ENOG4107RYR Transcriptional regulator, Crp Fnr family CHY23_01081 ENOG4105YP7 UPF0270 protein CHY23_01082 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CHY23_01083 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CHY23_01085 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CHY23_01086 ENOG4105W5Q DNA repair protein (RadC CHY23_01087 ENOG4105KDC 50s ribosomal protein l28 CHY23_01088 ENOG4105W0E 50S ribosomal protein L33 CHY23_01091 ENOG4108JPW Aminotransferase CHY23_01092 ENOG4105DY8 decarboxylase CHY23_01093 ENOG4105KSU Redox protein CHY23_01094 ENOG41066VF YeeE YedE family protein CHY23_01095 ENOG4108WFC UPF0438 protein yifE CHY23_01099 ENOG4107QUT magnesium and cobalt transport protein CorA CHY23_01100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CHY23_01102 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CHY23_01103 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CHY23_01104 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CHY23_01105 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CHY23_01106 ENOG4105D52 delta-aminolevulinic acid dehydratase CHY23_01109 ENOG4105CWM branched-chain amino acid transport system II carrier protein CHY23_01110 ENOG4105CHR reductase CHY23_01111 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CHY23_01112 ENOG4105WPN DNA integration recombination invertion protein CHY23_01113 ENOG4105EAH synthase CHY23_01115 ENOG4108YYH Nadph-dependent fmn reductase CHY23_01116 ENOG4105MGM doxx family CHY23_01117 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CHY23_01118 ENOG4105K46 50S ribosomal protein l27 CHY23_01119 ENOG4105QYV Membrane CHY23_01122 ENOG4105MJ2 Competence protein CHY23_01125 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CHY23_01126 ENOG4105C1J atp-dependent rna helicase CHY23_01128 ENOG4105DEF Extracellular solute-binding protein, family 5 CHY23_01130 ENOG4106HK8 GPR1 FUN34 yaaH family protein CHY23_01131 ENOG4105E0A ABC, transporter CHY23_01133 ENOG4105S6R Iron-hydroxamate transporter permease subunit CHY23_01138 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CHY23_01139 ENOG4105CIH Imidazole acetol-phosphate transaminase CHY23_01143 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CHY23_01146 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CHY23_01147 ENOG4105EX9 Membrane CHY23_01148 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CHY23_01150 ENOG4105WBN Transcriptional regulator (LacI family CHY23_01152 ENOG4105D7K pfkb domain protein CHY23_01153 ENOG4105CEI nitrite reductase CHY23_01154 ENOG4105D60 lipoprotein releasing system transmembrane protein CHY23_01155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CHY23_01156 ENOG4105D60 lipoprotein releasing system transmembrane protein CHY23_01157 ENOG4105C5I Dehydrogenase CHY23_01159 ENOG41063JG Transcriptional regulator CHY23_01160 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CHY23_01163 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CHY23_01164 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CHY23_01166 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CHY23_01167 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CHY23_01170 ENOG4105ERU peptidase CHY23_01174 ENOG4105CJN penicillin-binding protein CHY23_01175 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CHY23_01176 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CHY23_01178 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CHY23_01179 ENOG4105CNI cell division protein FtsW CHY23_01181 ENOG4105DFU Cell wall formation (By similarity) CHY23_01182 ENOG4105CPF Cell wall formation (By similarity) CHY23_01184 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CHY23_01185 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CHY23_01186 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CHY23_01187 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CHY23_01188 ENOG4108JQ5 ABC transporter CHY23_01189 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CHY23_01190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CHY23_01195 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CHY23_01196 ENOG4105C3G gtp-binding protein CHY23_01199 ENOG4108XTF Outer Membrane Lipoprotein CHY23_01200 ENOG4105NBI YecM protein CHY23_01201 ENOG4105C75 arginyL-tRNA synthetase CHY23_01203 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) CHY23_01204 ENOG4105C2N RNA methyltransferase TrmH family group 3 CHY23_01205 ENOG4105JIM Phosphatidylserine synthase CHY23_01206 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CHY23_01207 ENOG4105DTN riboflavin biosynthesis protein ribF CHY23_01208 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase CHY23_01209 ENOG4108VVQ metallophosphoesterase CHY23_01210 ENOG41065U4 response regulator CHY23_01212 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CHY23_01213 ENOG4105DFA alanine racemase domain protein CHY23_01216 ENOG4105CI3 gtp-binding protein typa CHY23_01217 ENOG41090BQ Glutaredoxin CHY23_01219 ENOG4105DSJ YicC domain protein CHY23_01220 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CHY23_01221 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CHY23_01222 ENOG4105WH1 Two component transcriptional regulator luxr family CHY23_01224 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CHY23_01230 ENOG4105DEF Extracellular solute-binding protein, family 5 CHY23_01231 ENOG4105DEF Extracellular solute-binding protein, family 5 CHY23_01232 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CHY23_01233 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CHY23_01234 ENOG4105C3U ABC transporter CHY23_01235 ENOG4108JQ7 (ABC) transporter CHY23_01238 ENOG4105M4H endoribonuclease L-psp CHY23_01239 ENOG4105CM2 brancheD-chain amino acid aminotransferase CHY23_01240 ENOG4105M2J Glutaredoxin CHY23_01241 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CHY23_01242 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CHY23_01244 ENOG4105M15 transport protein ExbD CHY23_01245 ENOG4105M8K biopolymer transport protein CHY23_01246 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) CHY23_01247 ENOG4107QR8 Thioredoxin CHY23_01248 ENOG4105VDH Dihydroxyacetone kinase CHY23_01249 ENOG4108UTZ Dihydroxyacetone kinase CHY23_01250 ENOG4105CMT Dihydroxyacetone kinase CHY23_01251 ENOG4105C3M thioredoxin reductase CHY23_01252 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) CHY23_01253 ENOG4105VP5 Bacterial protein of unknown function (DUF937) CHY23_01255 ENOG4108R99 pseudouridine synthase CHY23_01257 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 CHY23_01258 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) CHY23_01261 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CHY23_01264 ENOG4105C01 Dihydroxy-acid dehydratase CHY23_01265 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit CHY23_01267 ENOG4105EAU Plays a role in nitrite reduction (By similarity) CHY23_01268 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit CHY23_01269 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CHY23_01270 ENOG4105DVI reductase, NrfD CHY23_01271 ENOG4105EUR Domain-Containing protein CHY23_01271 ENOG4105EUR Domain-Containing protein CHY23_01271 ENOG4105EUR Domain-Containing protein CHY23_01272 ENOG4105C2W permease CHY23_01273 ENOG4105C26 Dehydrogenase CHY23_01274 ENOG4105CK7 Sodium proline symporter CHY23_01275 ENOG41069M3 Transcriptional regulator CHY23_01276 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CHY23_01278 ENOG4105E07 UPF0149 protein CHY23_01279 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CHY23_01280 ENOG4105R2J Conserved Protein CHY23_01281 ENOG4105K70 DNA-binding protein CHY23_01282 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CHY23_01285 ENOG4105VEQ Cold shock protein CHY23_01286 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) CHY23_01287 ENOG4105CN1 protease CHY23_01288 ENOG4105DIT ErfK YbiS YcfS YnhG family protein CHY23_01289 ENOG4105EAQ (twin-arginine translocation) pathway signal CHY23_01290 ENOG4105C5X domain protein CHY23_01293 ENOG4105K59 histidine triad (HIT) protein CHY23_01294 ENOG4105CC5 ABC transporter CHY23_01295 ENOG4105CC5 ABC transporter CHY23_01296 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CHY23_01297 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CHY23_01298 ENOG4105ETT transcriptional Regulator, LysR family CHY23_01299 ENOG4105PAD Hydrolase CHY23_01300 ENOG4107R11 Transcriptional regulator CHY23_01302 ENOG4105HDK L-asparaginase CHY23_01307 ENOG4107VHA regulatoR CHY23_01308 ENOG4107QQ0 gntp family CHY23_01309 ENOG4105BZW Glycerate kinase CHY23_01310 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 CHY23_01311 ENOG4105CPB ATP-dependent endonuclease of the OLD family CHY23_01312 ENOG4105EWT decarboxylase family CHY23_01313 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CHY23_01315 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CHY23_01316 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) CHY23_01317 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CHY23_01318 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CHY23_01319 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CHY23_01320 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CHY23_01321 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CHY23_01322 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) CHY23_01323 ENOG4105CJ2 (LipO)protein CHY23_01326 ENOG4105D8G Major Facilitator superfamily CHY23_01327 ENOG4105II7 pyrroline-5-carboxylate reductase CHY23_01329 ENOG4107VXZ Hydrolase CHY23_01332 ENOG4105DGN Electron transport complex CHY23_01333 ENOG4108R3D Electron transport complex CHY23_01334 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CHY23_01335 ENOG4105EN6 Membrane CHY23_01336 ENOG4105D6A Electron transport complex CHY23_01339 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CHY23_01341 ENOG4105DP9 ABC transporter CHY23_01342 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CHY23_01343 ENOG4105DJ0 Poly(A) Polymerase CHY23_01344 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CHY23_01346 ENOG4107H52 Dicarboxylate transport CHY23_01348 ENOG4108UYE Lactoylglutathione lyase CHY23_01349 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CHY23_01350 ENOG4105K3M )-transporter CHY23_01351 ENOG4105EHE chorismate mutase- prephenate dehydrogenase CHY23_01352 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CHY23_01353 ENOG4105DKP glycosyl transferase, family 9 CHY23_01354 ENOG4105CA9 Pyruvate kinase CHY23_01355 ENOG4108BY2 phosphohistidine phosphatase CHY23_01356 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CHY23_01357 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CHY23_01358 ENOG4105C8J )-transporter CHY23_01359 ENOG4105DFE Dna adenine methylase CHY23_01360 ENOG4105D49 3-dehydroquinate synthase CHY23_01361 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CHY23_01362 ENOG4108JQC penicillin-binding protein 1A CHY23_01367 ENOG4105E4G Type IV pilus CHY23_01368 ENOG4107YIM Involved in the transcription termination process (By similarity) CHY23_01369 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CHY23_01370 ENOG4108ZAI phosphatidylglycerophosphatase a CHY23_01371 ENOG4105CCF Lysine exporter protein (Lyse ygga) CHY23_01372 ENOG4105EIB trna rrna methyltransferase CHY23_01373 ENOG4105ECY inositol monophosphatase CHY23_01374 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CHY23_01375 ENOG4105DQ6 Transposase CHY23_01376 ENOG4105IYK transposase CHY23_01378 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CHY23_01379 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CHY23_01387 ENOG4105DQ6 Transposase CHY23_01388 ENOG4105IYK transposase CHY23_01389 ENOG4106B0W Curli production assembly transport component CsgG CHY23_01391 ENOG4107Y60 (LipO)protein CHY23_01392 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CHY23_01393 ENOG41082NX 50s ribosomal protein l35 CHY23_01394 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CHY23_01395 ENOG4108QD6 CHY23_01397 ENOG4105IYK transposase CHY23_01398 ENOG4105DQ6 Transposase CHY23_01399 ENOG4105C37 (CBS) domain CHY23_01400 ENOG4108W1A pseudouridine synthase CHY23_01401 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CHY23_01402 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CHY23_01403 ENOG4108UJU UPF0301 protein CHY23_01404 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CHY23_01406 ENOG4105M85 Bola protein CHY23_01411 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CHY23_01413 ENOG4105M6F mutator MutT protein CHY23_01414 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CHY23_01416 ENOG4105C8Y Acetylornithine aminotransferase CHY23_01420 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CHY23_01421 ENOG4105C6T cysteine synthase CHY23_01422 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CHY23_01423 ENOG4105CFH Aspartokinase CHY23_01424 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CHY23_01425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CHY23_01426 ENOG4107QYX exodeoxyribonuclease v alpha CHY23_01432 ENOG4105CIN aminoacyl-histidine dipeptidase CHY23_01433 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CHY23_01434 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CHY23_01435 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CHY23_01437 ENOG4108Z1B Cyclase dehydrase CHY23_01438 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CHY23_01439 ENOG4105E0C molybdate abc transporter CHY23_01440 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CHY23_01441 ENOG4105E3A (ABC) transporter CHY23_01442 ENOG4105DA5 (ABC) transporter CHY23_01443 ENOG4107QMP dna polymerase iii subunits gamma and tau CHY23_01444 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CHY23_01446 ENOG4105KME endoribonuclease L-psp CHY23_01447 ENOG4105C6T cysteine synthase CHY23_01448 ENOG4108KXH Ybak prolyl-tRNA synthetase associated CHY23_01449 ENOG4105DIK (ABC) transporter CHY23_01451 ENOG4108Z0T Part of a sulfur-relay system (By similarity) CHY23_01452 ENOG4108MN8 Membrane CHY23_01453 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CHY23_01455 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CHY23_01456 ENOG4108RE7 deoxyribonuclease CHY23_01457 ENOG4105C4R Atp-dependent dna helicase CHY23_01458 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CHY23_01459 ENOG4105F38 ABC transporter, permease CHY23_01460 ENOG4105D38 putrescine abc transporter CHY23_01464 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CHY23_01473 ENOG4105C5H ABC transporter CHY23_01474 ENOG4105CUZ uba thif-type nad fad binding protein CHY23_01476 ENOG4105C4M (Ubiquinol oxidase) subunit I CHY23_01477 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CHY23_01480 ENOG4107YD3 Thioesterase CHY23_01481 ENOG4105E02 MotA TolQ exbB proton channel CHY23_01484 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CHY23_01485 ENOG4105KCK Peptidoglycan-associated lipoprotein CHY23_01487 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) CHY23_01488 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CHY23_01489 ENOG4106K28 UPF0283 membrane protein CHY23_01490 ENOG4105C5H ABC transporter CHY23_01493 ENOG4105CVM Molybdenum cofactor synthesis domain protein CHY23_01494 ENOG4105D06 uba thif-type nad fad binding protein CHY23_01496 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CHY23_01497 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CHY23_01499 ENOG4105D3G Pseudouridine synthase CHY23_01500 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CHY23_01501 ENOG4105D6S protein involved in catabolism of external DNA CHY23_01502 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CHY23_01504 ENOG4105C28 cystathionine CHY23_01505 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) CHY23_01508 ENOG4105C9A Phoh family CHY23_01509 ENOG4105DQ6 Transposase CHY23_01510 ENOG4105IYK transposase CHY23_01512 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CHY23_01518 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CHY23_01522 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) CHY23_01524 ENOG4105D0A hydroxylase CHY23_01528 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CHY23_01529 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CHY23_01530 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CHY23_01531 ENOG4108IUZ ABC transporter CHY23_01532 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CHY23_01534 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CHY23_01535 ENOG4108WV1 Pfam:DUF477 CHY23_01537 ENOG4108V0P LemA family CHY23_01539 ENOG4105DM4 PTS System CHY23_01540 ENOG4105DE4 1-phosphofructokinase CHY23_01541 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CHY23_01543 ENOG4108ESZ Glycogen debranching enzyme CHY23_01544 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CHY23_01545 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CHY23_01546 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CHY23_01549 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CHY23_01552 ENOG4105I08 Pseudouridine synthase CHY23_01553 ENOG4105C2C drug resistance transporter, Bcr CflA CHY23_01555 ENOG4107XHZ cytoplasmic chaperone TorD family protein CHY23_01557 ENOG4107TT5 NLP P60 protein CHY23_01559 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) CHY23_01560 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CHY23_01561 ENOG4108MJ5 VirK protein CHY23_01563 ENOG4105CQ7 ATP-dependent helicase CHY23_01564 ENOG4108VMM UPF0756 membrane protein CHY23_01566 ENOG4107RUE extracellular solute-binding protein family 1 CHY23_01567 ENOG4107QI1 Mate efflux family protein CHY23_01568 ENOG4107QKA exodeoxyribonuclease V beta CHY23_01569 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CHY23_01570 ENOG4108JU5 Magnesium and cobalt efflux protein CHY23_01571 ENOG4108Q67 UPF0319 protein CHY23_01572 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CHY23_01573 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CHY23_01574 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CHY23_01575 ENOG4105CXY transporter CHY23_01576 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CHY23_01577 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CHY23_01578 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B CHY23_01579 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CHY23_01580 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CHY23_01581 ENOG4108R6K riboflavin synthase, subunit alpha CHY23_01584 ENOG4108RRZ Transcription elongation factor GreB CHY23_01585 ENOG4105C2X Arabinose 5-phosphate isomerase CHY23_01587 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CHY23_01588 ENOG4105C09 Bile acid CHY23_01589 ENOG4105ENT Efflux transporter rnd family, mfp subunit CHY23_01590 ENOG4105DQF Hydrolase CHY23_01591 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CHY23_01592 ENOG4105EMN RNA polymerase sigma factor CHY23_01593 ENOG41069PW sigma-e factor negative regulatory protein CHY23_01595 ENOG4105CEY Amp-dependent synthetase and ligase CHY23_01596 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CHY23_01597 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CHY23_01598 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CHY23_01599 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CHY23_01600 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CHY23_01603 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CHY23_01605 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CHY23_01608 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CHY23_01609 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CHY23_01611 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CHY23_01612 ENOG4105DZP Membrane-associated zinc metalloprotease CHY23_01613 ENOG4105KNE Phosphatidate cytidylyltransferase CHY23_01614 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CHY23_01615 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CHY23_01617 ENOG4105EYK Phosphatidylglycerophosphatase B CHY23_01618 ENOG4105HBR Rna-binding protein CHY23_01619 ENOG4106WTF Glycosyl transferase, family 2 CHY23_01620 ENOG41061WM D-Alanyl-D-Alanine CHY23_01621 ENOG4105M5K heptosyltransferase CHY23_01623 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CHY23_01624 ENOG4105E96 Colicin v production protein CHY23_01625 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CHY23_01627 ENOG4105D82 Glutamate dehydrogenase CHY23_01628 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CHY23_01630 ENOG4105KME endoribonuclease L-psp CHY23_01631 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CHY23_01635 ENOG4105E0X reductase CHY23_01636 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CHY23_01637 ENOG4105DFF Rod shape-determining protein mreb CHY23_01638 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CHY23_01640 ENOG4105D1H recombination factor protein RarA CHY23_01641 ENOG4105FAV ABC, transporter CHY23_01642 ENOG4105E7A Glutamine amidotransferase CHY23_01643 ENOG4105DWV Homoserine O-trans-acetylase CHY23_01644 ENOG4107GZ4 SanA protein CHY23_01648 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) CHY23_01649 ENOG4107QR9 Iron-sulfur cluster binding protein CHY23_01650 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CHY23_01651 ENOG4105DAA L-lactate CHY23_01652 ENOG4108SAU DNA-binding protein H-ns CHY23_01653 ENOG4107S6Z Na H antiporter CHY23_01654 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator CHY23_01655 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CHY23_01657 ENOG4108MJ5 VirK protein CHY23_01658 ENOG4105C7S Dehydrogenase CHY23_01659 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CHY23_01660 ENOG4105FDK ABC transporter CHY23_01661 ENOG4105DR5 peptidase CHY23_01662 ENOG4105T95 Thiol disulfide interChange protein CHY23_01663 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CHY23_01665 ENOG4108K4B hydrolase CHY23_01666 ENOG4105BZU Histidine kinase CHY23_01668 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CHY23_01670 ENOG4105CKU formyltetrahydrofolate synthetase CHY23_01671 ENOG4108ZZ3 UPF0260 protein CHY23_01672 ENOG4105EMU Dehydrogenase CHY23_01673 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CHY23_01675 ENOG4105X5T CHY23_01677 ENOG4105C2M dna polymerase I CHY23_01678 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CHY23_01679 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) CHY23_01680 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CHY23_01687 ENOG41080HT Transcriptional regulator, arsr family CHY23_01690 ENOG41080C8 DUF218 domain CHY23_01691 ENOG4105C6K Malic enzyme CHY23_01692 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CHY23_01709 ENOG4105YES addiction module antidote protein CHY23_01711 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CHY23_01712 ENOG4105RDA repressor CHY23_01718 ENOG4108MXB Protein of unknown function (DUF968) CHY23_01736 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CHY23_01750 ENOG41065CD Exported protein CHY23_01751 ENOG4105D7X high-affinity nickel-transporter CHY23_01752 ENOG4105BZG amino acid carrier protein CHY23_01753 ENOG4108YI8 ABC transporter CHY23_01754 ENOG4108YI8 ABC transporter CHY23_01755 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component CHY23_01756 ENOG4105D06 uba thif-type nad fad binding protein CHY23_01757 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CHY23_01758 ENOG4105D41 biosynthesis protein thiH CHY23_01759 ENOG4105ETU transcriptional activator (TenA CHY23_01760 ENOG4107Z6I Thiamine biosynthesis protein CHY23_01761 ENOG4105DWF phosphomethylpyrimidine kinase CHY23_01762 ENOG4105DWF phosphomethylpyrimidine kinase CHY23_01764 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CHY23_01765 ENOG4105C3F Signal peptidase i CHY23_01766 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CHY23_01767 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CHY23_01768 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CHY23_01783 ENOG4105C1J atp-dependent rna helicase CHY23_01785 ENOG4105D7A ATP-binding protein CHY23_01786 ENOG4105C4Y ABC transporter CHY23_01787 ENOG4107RCV ABC transporter, permease CHY23_01790 ENOG4105CQ0 ABC transporter CHY23_01791 ENOG4105CQ0 ABC transporter CHY23_01794 ENOG4108I6E Sulfatase CHY23_01795 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CHY23_01796 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CHY23_01797 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CHY23_01800 ENOG4108Z6B deaminase CHY23_01801 ENOG4105C1J atp-dependent rna helicase CHY23_01802 ENOG4105RT1 May be involved in cell division (By similarity) CHY23_01803 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CHY23_01804 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CHY23_01806 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) CHY23_01809 ENOG4105E68 Sulfatase CHY23_01810 ENOG4105YDX UPF0352 protein CHY23_01811 ENOG4105Y7M Transcriptional regulator, TetR family CHY23_01812 ENOG410624X efflux transporter, rnd family, mfp subunit CHY23_01813 ENOG4105BZS acriflavin resistance protein CHY23_01816 ENOG4105TWJ Domain of unknown function (DUF1919) CHY23_01817 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CHY23_01820 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CHY23_01821 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CHY23_01822 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CHY23_01823 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CHY23_01824 ENOG4105E0U tyrosine-specific transport protein CHY23_01825 ENOG4105E0U tyrosine-specific transport protein CHY23_01827 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III CHY23_01828 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CHY23_01830 ENOG4105D1Q UPF0246 protein CHY23_01832 ENOG41076HS cation diffusion facilitator family transporter CHY23_01833 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein CHY23_01834 ENOG4107R6U sodium dicarboxylate symporter CHY23_01835 ENOG4108RCM Nitroreductase CHY23_01837 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CHY23_01838 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CHY23_01839 ENOG4108QBX (LipO)protein CHY23_01840 ENOG4105DQ6 Transposase CHY23_01841 ENOG4105IYK transposase CHY23_01842 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CHY23_01843 ENOG4105E2R ROK family CHY23_01844 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CHY23_01845 ENOG4105EW9 transcriptional regulator AsnC family CHY23_01846 ENOG4105CNU cell division protein FtsK CHY23_01847 ENOG4105CGZ zinc metallopeptidase CHY23_01848 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CHY23_01849 ENOG41072GX Peptidase M22 Glycoprotease CHY23_01850 ENOG4107104 thymidine kinase CHY23_01851 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) CHY23_01852 ENOG4105CBT Fructose-1,6-bisphosphatase CHY23_01853 ENOG4107QNR UPF0135 protein CHY23_01854 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CHY23_01855 ENOG4105E0F Histidine kinase CHY23_01856 ENOG4105E0F Histidine kinase CHY23_01857 ENOG4105E3W Two component transcriptional regulator (Winged helix family CHY23_01858 ENOG4105DXN mazG family CHY23_01860 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CHY23_01862 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CHY23_01863 ENOG4105CHV Transcription elongation factor NusA CHY23_01864 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CHY23_01865 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CHY23_01866 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CHY23_01867 ENOG4105CVE Lytic murein transglycosylase CHY23_01868 ENOG4107EPN Domain of unknown function (DUF1508) CHY23_01869 ENOG4108DNC Involved in acetate metabolism (By similarity) CHY23_01871 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CHY23_01875 ENOG4108J3C UTP-glucose-1-phosphate uridylyltransferase CHY23_01877 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CHY23_01880 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CHY23_01881 ENOG4105KB2 stringent starvation protein b CHY23_01882 ENOG4107MKT Stringent starvation protein a CHY23_01883 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CHY23_01884 ENOG4105HDK L-asparaginase CHY23_01885 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CHY23_01886 ENOG4105CGF Aromatic amino acid aminotransferase CHY23_01887 ENOG4107RAQ aminopeptidase CHY23_01890 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CHY23_01891 ENOG410650H (LipO)protein CHY23_01892 ENOG4105DBE peroxidase CHY23_01894 ENOG4105DB7 PHP domain protein CHY23_01896 ENOG4105CJB Exodeoxyribonuclease I CHY23_01899 ENOG4105C5S asparaginyl-tRNA synthetase CHY23_01900 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CHY23_01902 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CHY23_01903 ENOG4105CX6 glutaminyL-tRNA synthetase CHY23_01905 ENOG4105C0R drug resistance transporter emrb qaca subfamily CHY23_01906 ENOG4107SC1 transglycosylase CHY23_01907 ENOG4108UGV hypoxanthine phosphoribosyltransferase CHY23_01908 ENOG4105C28 cystathionine CHY23_01909 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CHY23_01910 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CHY23_01912 ENOG4105M08 Membrane CHY23_01913 ENOG4105CXG d-lactate dehydrogenase CHY23_01914 ENOG4107QY8 reductase CHY23_01915 ENOG4105CUW cytochrome C-TYPE protein CHY23_01917 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CHY23_01918 ENOG4105M00 molybdopterin converting factor, subunit 1 CHY23_01919 ENOG4108ZAF Molybdopterin CHY23_01920 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CHY23_01921 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) CHY23_01922 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CHY23_01923 ENOG4105CC0 LysR family Transcriptional regulator CHY23_01925 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CHY23_01928 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CHY23_01929 ENOG4105C0D helicase CHY23_01932 ENOG4105QEK Transcriptional regulator CHY23_01933 ENOG4108R66 Conserved Protein CHY23_01934 ENOG4105C9X ppx gppa phosphatase CHY23_01936 ENOG4105CFH Aspartokinase CHY23_01937 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CHY23_01938 ENOG4105VNG YcgL domain-containing protein CHY23_01939 ENOG4105CDU Replicative dna helicase CHY23_01941 ENOG4105DHS permease protein CHY23_01942 ENOG4105CM4 permease protein CHY23_01943 ENOG4108IPW abc transporter atp-binding protein CHY23_01944 ENOG4107IX6 phosphate transport regulator CHY23_01945 ENOG4105CJ3 phosphate transporter CHY23_01948 ENOG4105NSG hemerythrin hhe cation binding domain protein CHY23_01949 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CHY23_01952 ENOG4105VEQ Cold shock protein CHY23_01953 ENOG41077A9 carbonic anhydrase CHY23_01954 ENOG4105C7K acetolactate synthase CHY23_01955 ENOG4108ZP8 Acetolactate synthase small subunit CHY23_01956 ENOG4105CMS peptidase U62, modulator of DNA gyrase CHY23_01957 ENOG4105N42 UPF0307 protein CHY23_01959 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CHY23_01960 ENOG4108UQV Membrane CHY23_01961 ENOG4108ZPB UPF0306 protein CHY23_01962 ENOG4108ZJT translation initiation factor, Sui1 CHY23_01963 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CHY23_01964 ENOG4105CFV Tetratricopeptide repeat protein CHY23_01965 ENOG4105Q4A inner membrane protein yciS CHY23_01966 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CHY23_01967 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CHY23_01968 ENOG4105CAT Cytidine monophosphate kinase CHY23_01969 ENOG4105C0H protease CHY23_01972 ENOG4108IYH Dna topoisomerase CHY23_01973 ENOG4105G6Z alkaline phosphatase CHY23_01974 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CHY23_01976 ENOG4105EGS Mechanosensitive ion channel CHY23_01977 ENOG4105EGS Mechanosensitive ion channel CHY23_01978 ENOG4105CEY Amp-dependent synthetase and ligase CHY23_01979 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) CHY23_01980 ENOG4105EV9 Alpha Beta Hydrolase CHY23_01981 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) CHY23_01982 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CHY23_01985 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) CHY23_01986 ENOG4105VAW lrga family CHY23_01987 ENOG41067MG lrgb family CHY23_01988 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CHY23_01991 ENOG4105DVA methyltransferase CHY23_01993 ENOG4105CHW UPF0052 protein CHY23_01995 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CHY23_01996 ENOG4108IYC Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CHY23_01997 ENOG41080IJ Diacylglycerol kinase CHY23_01998 ENOG4105CGH 5'-nucleotidase CHY23_02003 ENOG4107QN2 dihydrolipoyl dehydrogenase CHY23_02004 ENOG4107QSN dihydrolipoamide acetyltransferase CHY23_02005 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CHY23_02006 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CHY23_02007 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CHY23_02010 ENOG4105BZ1 (ABC) transporter CHY23_02011 ENOG41067MG lrgb family CHY23_02013 ENOG4105DVT helicase CHY23_02015 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CHY23_02016 ENOG4108UUM single-stranded DNA-binding protein CHY23_02021 ENOG4105EA8 2-Nitropropane dioxygenase CHY23_02023 ENOG4107RGD Major Facilitator superfamily CHY23_02024 ENOG4105UNS Pfam:DUF419 CHY23_02025 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein CHY23_02026 ENOG4108EU3 peptide transport system, permease CHY23_02028 ENOG4108EVY peptide transport periplasmic protein CHY23_02029 ENOG4108JU8 Transcriptional regulator CHY23_02030 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CHY23_02031 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CHY23_02032 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CHY23_02035 ENOG4105E0M Sulfatase CHY23_02036 ENOG4105QVC MOSC domain-containing protein CHY23_02038 ENOG4105CTB Polyprenyl synthetase CHY23_02040 ENOG4105CRK lysyL-tRNA synthetase CHY23_02041 ENOG4105C03 ribonuclease CHY23_02042 ENOG4105DDY UPF0142 protein ycaO CHY23_02047 ENOG4107QMH DNA methylase CHY23_02048 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CHY23_02050 ENOG4105CA3 membrane-bound lytic murein transglycosylase CHY23_02054 ENOG4105VT2 5-hydroxyisourate hydrolase CHY23_02056 ENOG4108VD1 dedA family CHY23_02057 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CHY23_02059 ENOG4105E98 transcriptional regulator DeoR family CHY23_02060 ENOG4107QTF adenylosuccinate lyase CHY23_02061 ENOG41075W9 High frequency lysogenization protein HflD homolog CHY23_02062 ENOG4108JJ8 (ABC) transporter CHY23_02063 ENOG4108JJ9 ABC, transporter CHY23_02064 ENOG4105MA0 exported protein CHY23_02065 ENOG4105CFU surface antigen CHY23_02066 ENOG4105PXI polysaccharide deacetylase CHY23_02067 ENOG41063SB peptidase CHY23_02068 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CHY23_02070 ENOG4105DBI uridine monophosphokinase CHY23_02071 ENOG4105DHP deoxycytidine triphosphate deaminase CHY23_02073 ENOG4105D0S secretion protein (HlyD CHY23_02074 ENOG4105CJ1 ABC, transporter CHY23_02075 ENOG4105CMI transporter CHY23_02077 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CHY23_02078 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CHY23_02079 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CHY23_02081 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CHY23_02082 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CHY23_02083 ENOG4105CSA Coproporphyrinogen iii oxidase CHY23_02084 ENOG4107QSI ABC, transporter CHY23_02087 ENOG4108JQ7 (ABC) transporter CHY23_02090 ENOG4105SYT Methylenetetrahydrofolate reductase CHY23_02092 ENOG4105DEF Extracellular solute-binding protein, family 5 CHY23_02094 ENOG4105C44 Serine transporter CHY23_02095 ENOG4105EJQ L-serine dehydratase CHY23_02097 ENOG4105DK0 Indole-3-glycerol phosphate synthase CHY23_02099 ENOG4105WP7 tRNA pseudouridine synthase C CHY23_02100 ENOG4105DR9 pseudouridine synthase CHY23_02103 ENOG4105I7R Adenylate cyclase CHY23_02104 ENOG4105CM6 amino acid regulated cytosolic protein CHY23_02105 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CHY23_02107 ENOG4105CH2 amidohydrolase CHY23_02110 ENOG4105C8T Leucyl-tRNA synthetase CHY23_02112 ENOG4105DJF DNA polymerase III, delta' subunit CHY23_02113 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CHY23_02114 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CHY23_02116 ENOG4105D7Q type ii secretion system CHY23_02117 ENOG4107QHF type ii secretion system protein e CHY23_02119 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CHY23_02121 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CHY23_02122 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CHY23_02123 ENOG4105EJ9 Membrane CHY23_02124 ENOG4105CSM endonuclease III CHY23_02129 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CHY23_02130 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CHY23_02131 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CHY23_02132 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CHY23_02133 ENOG4108MG3 formate dehydrogenase CHY23_02134 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) CHY23_02140 ENOG4105D1S lipid A biosynthesis CHY23_02141 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA CHY23_02143 ENOG4105EUJ GTP cyclohydrolase i CHY23_02144 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) CHY23_02146 ENOG4108UW5 maltose o-acetyltransferase CHY23_02147 ENOG4105ENX hydrolase CHY23_02151 ENOG4105HVQ Regulatory factor of maltose metabolism CHY23_02152 ENOG4106YXT transposase CHY23_02153 ENOG4108WTW DNA transposition protein CHY23_02156 ENOG4105IKI host-nuclease inhibitor protein CHY23_02163 ENOG4105ZIA Phage protein gp16 CHY23_02164 ENOG41065S5 CHY23_02173 ENOG4108Z6H mu-like prophage Flumu protein gp27 CHY23_02174 ENOG4105CF2 Mu-like prophage FluMu protein GP28 CHY23_02175 ENOG4105QIB mu-like prophage Flumu protein gp29 CHY23_02176 ENOG4108QUU Morphogenesis Protein CHY23_02177 ENOG4105ZS4 g protein CHY23_02178 ENOG4108TVE i protein CHY23_02179 ENOG4105EFV Major head subunit CHY23_02181 ENOG4105Y5J prophage protein CHY23_02182 ENOG41067KA Domain of unknown function (DUF1834) CHY23_02194 ENOG4107H6E CHY23_02195 ENOG4105ENX hydrolase CHY23_02196 ENOG4105EQ2 LysR family Transcriptional regulator CHY23_02197 ENOG4105D01 (LipO)protein CHY23_02198 ENOG4105D01 (LipO)protein CHY23_02199 ENOG4108UMI ABC transporter, permease CHY23_02200 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CHY23_02202 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CHY23_02203 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CHY23_02204 ENOG4105IYK transposase CHY23_02205 ENOG4105DQ6 Transposase CHY23_02206 ENOG4105UGU tonB-dependent Receptor CHY23_02209 ENOG4105WVQ Fe-S assembly protein IscX CHY23_02210 ENOG4108ZIT Ferredoxin, 2FE-2S CHY23_02212 ENOG4108RF1 Protein of unknown function DUF2625 CHY23_02214 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) CHY23_02215 ENOG4108Z4V iron-sulfur cluster assembly CHY23_02216 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CHY23_02217 ENOG4105C3J Cysteine desulfurase CHY23_02218 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CHY23_02219 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation CHY23_02220 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CHY23_02221 ENOG4105BZU Histidine kinase CHY23_02222 ENOG4108TZV Membrane CHY23_02223 ENOG4108DG9 Smr protein MutS2 CHY23_02224 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CHY23_02225 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CHY23_02226 ENOG4105HSA Protein of unknown function (DUF452) CHY23_02227 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CHY23_02228 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CHY23_02229 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CHY23_02230 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CHY23_02231 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase CHY23_02235 ENOG4108J1Q CHY23_02238 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) CHY23_02239 ENOG4105DC1 bifunctional purine biosynthesis protein purh CHY23_02242 ENOG4105CKT filamentous hemagglutinin CHY23_02243 ENOG4105D5K Hemolysin activator protein CHY23_02244 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CHY23_02245 ENOG4105D4P Coproporphyrinogen iii oxidase CHY23_02248 ENOG4105D0C transport protein CHY23_02249 ENOG4105D6U Sodium Glutamate Symporter CHY23_02251 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CHY23_02252 ENOG4105K9H YciI-like protein CHY23_02253 ENOG4105NAU thioesterase Superfamily protein CHY23_02256 ENOG4105PQ6 UPF0208 membrane protein CHY23_02258 ENOG4105D3Y Na H antiporter CHY23_02259 ENOG4105CGK Exodeoxyribonuclease III CHY23_02260 ENOG4105EMY transcriptional regulator CHY23_02262 ENOG4105W1T Glycosyl Transferase CHY23_02265 ENOG4105VFB Binds the 23S rRNA (By similarity) CHY23_02266 ENOG4105CV1 Transketolase (EC 2.2.1.1) CHY23_02268 ENOG4105CH6 catalase CHY23_02269 ENOG4105IYK transposase CHY23_02270 ENOG4105DQ6 Transposase CHY23_02271 ENOG4107RN3 metallophosphoesterase CHY23_02272 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CHY23_02274 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CHY23_02275 ENOG4105F0Z galactose-1-phosphate uridylyltransferase CHY23_02277 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CHY23_02278 ENOG4105CNT hydrolase family 2