locus-tag	class	description
D1095_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1095_00010	COG0592	DNA-directed DNA polymerase activity
D1095_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1095_00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1095_00040	COG0616	signal peptide processing
D1095_00055	COG3116	cell division
D1095_00060	COG0768	penicillin binding
D1095_00065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1095_00070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1095_00080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1095_00085	COG0772	Belongs to the SEDS family
D1095_00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1095_00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1095_00110	COG0849	cell division
D1095_00115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1095_00125	COG0497	DNA recombination
D1095_00135	COG4172	Belongs to the ABC transporter superfamily
D1095_00140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1095_00145	COG0601	transmembrane transport
D1095_00175	COG0012	GTP binding
D1095_00180	COG2020	methyltransferase activity
D1095_00190	COG3133	Outer membrane lipoprotein
D1095_00195	COG3102	Protein conserved in bacteria
D1095_00200	COG0018	arginyl-trna synthetase
D1095_00215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1095_00220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1095_00225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1095_00230	COG0196	riboflavin kinase activity
D1095_00235	COG3172	ATPase kinase involved in NAD metabolism
D1095_00240	COG2129	metallophosphoesterase
D1095_00245	COG0745	RESPONSE REGULATOR receiver
D1095_00255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1095_00260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1095_00270	COG1217	gtp-binding protein TYPA
D1095_00275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1095_00280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1095_00285	COG1561	YicC-like family, N-terminal region
D1095_00290	COG0354	folic acid binding
D1095_00295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1095_00300	COG2197	response regulator
D1095_00310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1095_00345	COG0747	negative chemotaxis
D1095_00350	COG0601	transmembrane transport
D1095_00355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1095_00360	COG0444	Belongs to the ABC transporter superfamily
D1095_00365	COG4608	Belongs to the ABC transporter superfamily
D1095_00380	COG0251	oxidation-reduction process
D1095_00385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1095_00390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1095_00395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1095_00400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1095_00405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D1095_00410	COG0848	biopolymer transport protein
D1095_00415	COG0811	peptide transport
D1095_00420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1095_00425	COG3118	belongs to the thioredoxin family
D1095_00430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1095_00430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_00430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D1095_00435	COG1461	Dihydroxyacetone kinase
D1095_00440	COG2376	Dihydroxyacetone kinase
D1095_00445	COG0492	ferredoxin-NADP+ reductase activity
D1095_00455	COG3753	Protein conserved in bacteria
D1095_00475	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1095_00480	COG0006	proline dipeptidase activity
D1095_00490	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D1095_00515	COG3978	acetolactate synthase activity
D1095_00530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D1095_00535	COG0437	4 iron, 4 sulfur cluster binding
D1095_00540	COG3301	Polysulphide reductase, NrfD
D1095_00570	COG5295	Hep Hag repeat protein
D1095_00570	COG5295	Hep Hag repeat protein
D1095_00570	COG5295	Hep Hag repeat protein
D1095_00585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1095_00590	COG1414	Transcriptional regulator
D1095_00595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1095_00605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D1095_00615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1095_00620	COG3068	Protein conserved in bacteria
D1095_00640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1095_00645	COG1278	Cold shock
D1095_00650	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D1095_00655	COG0793	Belongs to the peptidase S41A family
D1095_00660	COG2989	Protein conserved in bacteria
D1095_00665	COG3108	Peptidase M15
D1095_00670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1095_00685	COG0537	adenosine 5'-monophosphoramidase activity
D1095_00690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1095_00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1095_00700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1095_00705	COG1162	GTPase activity
D1095_00710	COG0583	DNA-binding transcription factor activity
D1095_00715	COG1011	Hydrolase
D1095_00720	COG0583	DNA-binding transcription factor activity
D1095_00730	COG0252	asparaginase activity
D1095_00740	COG5413	integral membrane protein
D1095_00755	COG3835	regulator
D1095_00760	COG2610	gluconate transmembrane transporter activity
D1095_00765	COG1929	Belongs to the glycerate kinase type-1 family
D1095_00770	COG1254	Belongs to the acylphosphatase family
D1095_00775	COG3593	DNA synthesis involved in DNA repair
D1095_00780	COG1611	Belongs to the LOG family
D1095_00785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1095_00795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1095_00800	COG0316	Belongs to the HesB IscA family
D1095_00800	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D1095_00805	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_00810	COG1805	sodium ion transport
D1095_00815	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_00820	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_00825	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1095_00830	COG2871	sodium ion transport
D1095_00835	COG1477	protein flavinylation
D1095_00840	COG2991	Protein conserved in bacteria
D1095_00845	COG0482	sulfurtransferase activity
D1095_00850	COG2814	Major facilitator Superfamily
D1095_00855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1095_00860	COG2974	May be involved in recombination
D1095_00865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1095_00880	COG4657	Part of a membrane complex involved in electron transport
D1095_00885	COG2878	Part of a membrane complex involved in electron transport
D1095_00890	COG4656	Part of a membrane complex involved in electron transport
D1095_00915	COG1560	Kdo2-lipid A biosynthetic process
D1095_00920	COG0402	S-adenosylhomocysteine deaminase activity
D1095_00925	COG4143	(ABC) transporter
D1095_00930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1095_00935	COG0617	tRNA 3'-terminal CCA addition
D1095_00940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1095_00950	COG2911	Protein conserved in bacteria
D1095_00960	COG0346	lactoylglutathione lyase activity
D1095_00965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1095_00975	COG0287	Prephenate dehydrogenase
D1095_00975	COG1605	Chorismate mutase
D1095_00980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1095_00985	COG0859	PFAM glycosyl transferase family 9
D1095_00990	COG0469	pyruvate kinase activity
D1095_00995	COG2062	phosphohistidine phosphatase, SixA
D1095_01000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1095_01005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D1095_01010	COG0733	neurotransmitter:sodium symporter activity
D1095_01015	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D1095_01020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1095_01025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1095_01030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1095_01035	COG4972	Pilus assembly protein
D1095_01055	COG4796	Type ii and iii secretion system protein
D1095_01060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1095_01065	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1095_01070	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D1095_01075	COG1280	lysine exporter protein (LysE YggA)
D1095_01080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1095_01090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1095_01105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1095_01160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1095_01165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1095_01170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1095_01185	COG1253	flavin adenine dinucleotide binding
D1095_01190	COG0564	pseudouridine synthase activity
D1095_01195	COG0588	phosphoglycerate mutase activity
D1095_01200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1095_01205	COG1678	Uncharacterized ACR, COG1678
D1095_01210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1095_01220	COG0271	Belongs to the BolA IbaG family
D1095_01245	COG0653	protein targeting
D1095_01255	COG0494	nUDIX hydrolase
D1095_01260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1095_01270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1095_01280	COG1629	transport
D1095_01280	COG4771	TonB-dependent receptor
D1095_01285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D1095_01290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1095_01295	COG0083	homoserine kinase activity
D1095_01300	COG0460	homoserine dehydrogenase
D1095_01300	COG0527	aspartate kinase activity
D1095_01305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1095_01310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1095_01315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1095_01350	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1095_01355	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1095_01360	COG0194	GDP metabolic process
D1095_01365	COG1538	Outer membrane efflux protein
D1095_01370	COG2914	Belongs to the UPF0125 (RnfH) family
D1095_01375	COG2867	negative regulation of translational initiation
D1095_01380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1095_01385	COG4149	molybdate abc transporter
D1095_01390	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1095_01395	COG0842	Transport permease protein
D1095_01400	COG1131	(ABC) transporter
D1095_01405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1095_01410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1095_01420	COG0251	oxidation-reduction process
D1095_01425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1095_01430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1095_01435	COG1121	(ABC) transporter
D1095_01445	COG2920	part of a sulfur-relay system
D1095_01450	COG0670	Belongs to the BI1 family
D1095_01455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1095_01465	COG0322	excinuclease ABC activity
D1095_01470	COG0084	hydrolase, TatD family'
D1095_01475	COG0210	DNA helicase
D1095_01480	COG3842	ATPase activity
D1095_01485	COG1176	ABC-type spermidine putrescine transport system, permease component I
D1095_01490	COG1177	transmembrane transport
D1095_01495	COG0632	four-way junction helicase activity
D1095_01500	COG2255	four-way junction helicase activity
D1095_01505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1095_01510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1095_01560	COG0488	(ABC) transporter
D1095_01565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1095_01575	COG1271	oxidase subunit
D1095_01580	COG1294	oxidase, subunit
D1095_01595	COG0824	Thioesterase
D1095_01600	COG0811	peptide transport
D1095_01605	COG0848	biopolymer transport protein
D1095_01610	COG3064	Membrane
D1095_01610	COG3064	Membrane
D1095_01615	COG0823	Involved in the tonB-independent uptake of proteins
D1095_01630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1095_01635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1095_01645	COG0488	(ABC) transporter
D1095_01655	COG0303	'Molybdopterin
D1095_01660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1095_01670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1095_01675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1095_01680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1095_01685	COG0564	pseudouridine synthase activity
D1095_01690	COG3023	N-Acetylmuramoyl-L-alanine amidase
D1095_01695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1095_01700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1095_01705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1095_01710	COG0626	cystathionine gamma-synthase activity
D1095_01715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1095_01730	COG1702	phosphate starvation-inducible protein PhoH
D1095_01755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1095_01775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1095_01785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_01790	COG1137	ATPase activity
D1095_01795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D1095_01805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1095_01810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D1095_01820	COG1704	LemA family
D1095_01825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1095_01825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1095_01825	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D1095_01830	COG1105	Belongs to the carbohydrate kinase PfkB family
D1095_01835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_01835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_01845	COG1523	belongs to the glycosyl hydrolase 13 family
D1095_01850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1095_01855	COG0297	glycogen (starch) synthase activity
D1095_01860	COG0058	SHG alpha-glucan phosphorylase activity
D1095_01865	COG0105	UTP biosynthetic process
D1095_01885	COG1187	pseudouridine synthase activity
D1095_01890	COG2814	Major facilitator Superfamily
D1095_01900	COG3381	protein complex oligomerization
D1095_01910	COG0791	NLP P60 protein
D1095_01915	COG2932	Transcriptional regulator
D1095_01920	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D1095_01925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1095_01930	COG2990	Protein conserved in bacteria
D1095_01940	COG1643	Atp-dependent helicase
D1095_01945	COG2707	UPF0756 membrane protein
D1095_01950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1095_01955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1095_01960	COG0534	Mate efflux family protein
D1095_01965	COG1074	ATP-dependent DNA helicase activity
D1095_01970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1095_01975	COG4535	Mg2 and Co2 transporter CorC
D1095_01985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1095_01990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1095_01995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1095_02000	COG2271	Major facilitator Superfamily
D1095_02005	COG0584	glycerophosphoryl diester phosphodiesterase
D1095_02010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1095_02015	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
D1095_02020	COG0247	lactate metabolic process
D1095_02050	COG0517	IMP dehydrogenase activity
D1095_02050	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1095_02060	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D1095_02065	COG0385	Bile acid
D1095_02070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_02075	COG0561	phosphatase activity
D1095_02090	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D1095_02100	COG0318	PFAM AMP-dependent synthetase and ligase
D1095_02105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1095_02110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1095_02115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1095_02120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1095_02125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1095_02125	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1095_02130	COG1160	GTP binding
D1095_02140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1095_02155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1095_02160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1095_02175	COG0750	zinc metalloprotease
D1095_02180	COG0575	Belongs to the CDS family
D1095_02185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1095_02190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1095_02200	COG0671	phosphoesterase, PA-phosphatase related
D1095_02205	COG1534	Rna-binding protein
D1095_02210	COG0463	Glycosyl transferase, family 2
D1095_02215	COG1686	Belongs to the peptidase S11 family
D1095_02220	COG0859	PFAM glycosyl transferase family 9
D1095_02230	COG0328	RNA-DNA hybrid ribonuclease activity
D1095_02235	COG1286	toxin biosynthetic process
D1095_02240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1095_02250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1095_02255	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1095_02265	COG0251	oxidation-reduction process
D1095_02270	COG1496	oxidoreductase activity
D1095_02280	COG5645	(Lipo)protein
D1095_02295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1095_02305	COG1792	Involved in formation and maintenance of cell shape
D1095_02310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D1095_02315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1095_02320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1095_02325	COG0121	glutamine amidotransferase
D1095_02330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1095_02335	COG2949	membrane
D1095_02375	COG1556	Lactate utilization protein
D1095_02380	COG1139	Iron-sulfur cluster binding protein
D1095_02385	COG0247	lactate metabolic process
D1095_02390	COG1620	l-lactate permease
D1095_02395	COG2916	Histone family protein nucleoid-structuring protein H-NS
D1095_02400	COG1757	Na H antiporter
D1095_02405	COG1879	ABC-type sugar transport system periplasmic component
D1095_02410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1095_02415	COG0045	succinate-CoA ligase (ADP-forming) activity
D1095_02420	COG2990	Protein conserved in bacteria
D1095_02425	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1095_02430	COG0567	Dehydrogenase, E1 component
D1095_02435	COG1121	(ABC) transporter
D1095_02440	COG0739	heme binding
D1095_02445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1095_02450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1095_02460	COG0561	phosphatase activity
D1095_02465	COG3850	Histidine kinase
D1095_02475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1095_02480	COG0393	Putative heavy-metal-binding
D1095_02485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1095_02495	COG4221	oxidoreductase activity
D1095_02515	COG2801	Transposase and inactivated derivatives
D1095_02525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1095_02525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1095_02530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D1095_02540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1095_02545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1095_02570	COG0640	Transcriptional regulator
D1095_02580	COG0189	ligase activity
D1095_02585	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1095_02590	COG0281	malic enzyme
D1095_02590	COG0280	phosphate acetyltransferase
D1095_02605	COG3683	transport system, periplasmic component
D1095_02610	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D1095_02615	COG1115	amino acid carrier protein
D1095_02620	COG1116	anion transmembrane transporter activity
D1095_02625	COG1116	anion transmembrane transporter activity
D1095_02630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1095_02640	COG2104	thiamine diphosphate biosynthetic process
D1095_02650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1095_02655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1095_02660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1095_02675	COG0481	GTPase activity
D1095_02680	COG0681	Belongs to the peptidase S26 family
D1095_02685	COG0571	ribonuclease III activity
D1095_02690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1095_02695	COG1381	Involved in DNA repair and RecF pathway recombination
D1095_02745	COG4964	Belongs to the GSP D family
D1095_02760	COG0433	COG0433 Predicted ATPase
D1095_02775	COG1840	ABC-type Fe3 transport system, periplasmic component
D1095_02790	COG4178	(ABC) transporter
D1095_02800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1095_02805	COG2194	sulfuric ester hydrolase activity
D1095_02810	COG0528	UMP kinase activity
D1095_02815	COG0233	cytoplasmic translational termination
D1095_02820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1095_02825	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1095_02835	COG0590	tRNA wobble adenosine to inosine editing
D1095_02840	COG0513	Belongs to the DEAD box helicase family
D1095_02845	COG4785	May be involved in cell division
D1095_02850	COG1185	polyribonucleotide nucleotidyltransferase activity
D1095_02855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1095_02870	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D1095_02885	COG3083	sulfuric ester hydrolase activity
D1095_02890	COG3082	Protein of unknown function (DUF1414)
D1095_02895	COG1309	transcriptional regulator
D1095_02900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_02905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1095_02910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1095_02920	COG3955	Domain of unknown function (DUF1919)
D1095_02925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1095_02940	COG0517	IMP dehydrogenase activity
D1095_02940	COG0516	GMP reductase activity
D1095_02945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1095_02950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1095_02955	COG0814	amino acid
D1095_02960	COG0814	amino acid
D1095_02975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1095_02985	COG3022	response to hydroperoxide
D1095_03000	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D1095_03005	COG1823	symporter activity
D1095_03010	COG0778	Nitroreductase
D1095_03020	COG0072	phenylalanine-tRNA ligase activity
D1095_03025	COG0776	regulation of translation
D1095_03030	COG0791	NLP P60 protein
D1095_03040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1095_03045	COG1846	Transcriptional regulator
D1095_03045	COG1940	carbohydrate kinase activity
D1095_03050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D1095_03055	COG1522	sequence-specific DNA binding
D1095_03060	COG1674	ftsk spoiiie
D1095_03065	COG2321	neutral zinc metallopeptidase
D1095_03070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1095_03075	COG1214	PFAM Peptidase M22, glycoprotease
D1095_03080	COG1435	thymidine kinase activity
D1095_03085	COG3074	FtsZ-dependent cytokinesis
D1095_03090	COG1494	fructose-1,6-bisphosphatase
D1095_03095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1095_03100	COG1136	(ABC) transporter
D1095_03100	COG0577	efflux transmembrane transporter activity
D1095_03105	COG2205	protein histidine kinase activity
D1095_03110	COG0745	RESPONSE REGULATOR receiver
D1095_03115	COG3956	TIGRFAM MazG family protein
D1095_03125	COG0285	dihydrofolate synthase activity
D1095_03135	COG0779	Required for maturation of 30S ribosomal subunits
D1095_03140	COG0195	Participates in both transcription termination and antitermination
D1095_03145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1095_03150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1095_03155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1095_03160	COG2951	lytic endotransglycosylase activity
D1095_03170	COG0280	phosphate acetyltransferase
D1095_03170	COG0857	belongs to the CobB CobQ family
D1095_03180	COG0737	Belongs to the 5'-nucleotidase family
D1095_03200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1095_03210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D1095_03220	COG0589	response to stress
D1095_03230	COG2969	positive regulation of protein catabolic process
D1095_03235	COG0625	glutathione transferase activity
D1095_03240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1095_03250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1095_03255	COG1448	Aminotransferase
D1095_03260	COG0006	proline dipeptidase activity
D1095_03270	COG0556	nucleotide-excision repair
D1095_03280	COG2822	iron ion transport
D1095_03285	COG2837	iron assimilation
D1095_03295	COG0613	PHP domain protein
D1095_03305	COG2925	Exonuclease
D1095_03310	COG0038	chloride channel
D1095_03320	COG1509	lysine 2,3-aminomutase activity
D1095_03330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1095_03335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1095_03340	COG2814	Major facilitator Superfamily
D1095_03345	COG0741	lytic transglycosylase activity
D1095_03350	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1095_03355	COG0626	cystathionine gamma-synthase activity
D1095_03360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1095_03365	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D1095_03370	COG2363	Small membrane protein
D1095_03375	COG0277	FAD linked oxidase domain protein
D1095_03380	COG0243	molybdopterin cofactor binding
D1095_03385	COG3005	denitrification pathway
D1095_03390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1095_03395	COG0315	cyclic pyranopterin monophosphate synthase activity
D1095_03400	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D1095_03405	COG0314	molybdopterin synthase activity
D1095_03410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1095_03415	COG1444	tRNA N-acetyltransferase activity
D1095_03425	COG0583	DNA-binding transcription factor activity
D1095_03450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1095_03455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1095_03475	COG1737	Transcriptional regulator
D1095_03480	COG2731	YhcH YjgK YiaL family protein
D1095_03485	COG0248	Ppx GppA phosphatase
D1095_03490	COG2926	Belongs to the UPF0265 family
D1095_03495	COG0527	aspartate kinase activity
D1095_03500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1095_03505	COG3100	YcgL domain-containing protein
D1095_03510	COG0305	Participates in initiation and elongation during chromosome replication
D1095_03515	COG4607	ABC-type enterochelin transport system periplasmic component
D1095_03520	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1095_03525	COG4605	iron ion homeostasis
D1095_03530	COG4604	ABC transporter, ATP-binding protein
D1095_03535	COG1392	Phosphate transport regulator
D1095_03540	COG0306	phosphate transporter
D1095_03545	COG4991	sh3 domain protein
D1095_03555	COG3945	hemerythrin HHE cation binding domain
D1095_03560	COG0343	queuine tRNA-ribosyltransferase activity
D1095_03570	COG1278	Cold shock
D1095_03575	COG0288	reversible hydration of carbon dioxide
D1095_03580	COG0028	Belongs to the TPP enzyme family
D1095_03585	COG0440	acetolactate synthase activity
D1095_03590	COG0312	modulator of DNA gyrase
D1095_03595	COG3028	Belongs to the UPF0307 family
D1095_03600	COG3094	Invasion gene expression up-regulator, SirB
D1095_03610	COG1811	Na channel or pump
D1095_03615	COG3787	Belongs to the UPF0306 family
D1095_03620	COG0023	Translation Initiation Factor
D1095_03625	COG0284	orotidine-5'-phosphate decarboxylase activity
D1095_03630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D1095_03635	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D1095_03640	COG0776	regulation of translation
D1095_03645	COG0539	negative regulation of cytoplasmic translation
D1095_03655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1095_03665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1095_03675	COG1785	Belongs to the alkaline phosphatase family
D1095_03680	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D1095_03690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1095_03690	COG3264	Mechanosensitive ion channel
D1095_03695	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1095_03695	COG3264	Mechanosensitive ion channel
D1095_03700	COG0318	PFAM AMP-dependent synthetase and ligase
D1095_03705	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D1095_03710	COG0596	Alpha beta hydrolase
D1095_03715	COG2226	methyltransferase
D1095_03720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1095_03740	COG1380	Effector of murein hydrolase LrgA
D1095_03745	COG1346	cytolysis
D1095_03750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1095_03760	COG3036	rescue of stalled ribosome
D1095_03765	COG2226	methyltransferase
D1095_03785	COG0658	competence protein
D1095_03785	COG2333	competence protein COMEC
D1095_03790	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D1095_03800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1095_03805	COG0737	Belongs to the 5'-nucleotidase family
D1095_03830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1095_03835	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1095_03840	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1095_03850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1095_03860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D1095_03865	COG1132	(ABC) transporter
D1095_03870	COG1346	cytolysis
D1095_03880	COG1199	ATP-dependent helicase activity
D1095_03890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1095_03895	COG0629	single-stranded DNA binding
D1095_03935	COG2070	2-Nitropropane dioxygenase
D1095_03945	COG2315	Protein conserved in bacteria
D1095_03950	COG4172	Belongs to the ABC transporter superfamily
D1095_03955	COG4171	peptide transport system, permease
D1095_03960	COG4168	peptide transport system, permease
D1095_03965	COG4166	transmembrane transport
D1095_03970	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D1095_03975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1095_03980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1095_03985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D1095_04005	COG1368	sulfuric ester hydrolase activity
D1095_04010	COG3217	Mosc domain protein beta barrel domain protein
D1095_04010	COG0633	Ferredoxin
D1095_04015	COG1722	exodeoxyribonuclease VII activity
D1095_04020	COG0142	geranyltranstransferase activity
D1095_04030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1095_04035	COG1530	ribonuclease E activity
D1095_04040	COG1944	ATP diphosphatase activity
D1095_04045	COG2801	Transposase and inactivated derivatives
D1095_04060	COG0500	methyltransferase
D1095_04070	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D1095_04090	COG2351	hydroxyisourate hydrolase activity
D1095_04100	COG0586	Pfam SNARE associated Golgi protein
D1095_04105	COG0187	DNA topoisomerase II activity
D1095_04110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1095_04115	COG1349	DNA-binding transcription factor activity
D1095_04120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1095_04130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D1095_04135	COG4988	ABC transporter
D1095_04140	COG2911	Protein conserved in bacteria
D1095_04145	COG0729	surface antigen
D1095_04150	COG2861	carbohydrate metabolic process
D1095_04155	COG4942	peptidase
D1095_04160	COG0588	phosphoglycerate mutase activity
D1095_04170	COG0572	uridine kinase
D1095_04175	COG0717	Belongs to the dCTP deaminase family
D1095_04180	COG1309	transcriptional regulator
D1095_04185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_04190	COG0842	Transport permease protein
D1095_04190	COG1129	ABC transporter
D1095_04195	COG0842	Transport permease protein
D1095_04205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1095_04210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1095_04215	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1095_04225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1095_04230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1095_04235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1095_04240	COG4166	transmembrane transport
D1095_04250	COG0444	Belongs to the ABC transporter superfamily
D1095_04255	COG4608	Belongs to the ABC transporter superfamily
D1095_04265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1095_04275	COG0747	negative chemotaxis
D1095_04280	COG0814	amino acid
D1095_04285	COG1760	l-serine dehydratase
D1095_04290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1095_04290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1095_04295	COG0135	phosphoribosylanthranilate isomerase activity
D1095_04295	COG0134	indole-3-glycerol-phosphate synthase activity
D1095_04300	COG3177	Filamentation induced by cAMP protein fic
D1095_04305	COG3098	single-species biofilm formation
D1095_04310	COG0564	pseudouridine synthase activity
D1095_04315	COG3140	Belongs to the UPF0181 family
D1095_04325	COG3025	triphosphatase activity
D1095_04330	COG3106	COG3106 Predicted ATPase
D1095_04335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1095_04345	COG1473	amidohydrolase
D1095_04350	COG3069	C4-dicarboxylate transmembrane transporter activity
D1095_04360	COG0495	leucyl-tRNA aminoacylation
D1095_04365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D1095_04370	COG1466	dna polymerase III delta subunit
D1095_04375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1095_04380	COG0237	dephospho-CoA kinase activity
D1095_04390	COG1459	type II secretion system
D1095_04395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1095_04400	COG4969	Belongs to the N-Me-Phe pilin family
D1095_04405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1095_04415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1095_04420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1095_04425	COG0730	response to heat
D1095_04430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1095_04435	COG0183	Belongs to the thiolase family
D1095_04440	COG1024	Enoyl-CoA hydratase
D1095_04440	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1095_04455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1095_04460	COG3383	formate dehydrogenase (NAD+) activity
D1095_04460	COG0243	molybdopterin cofactor binding
D1095_04465	COG3383	formate dehydrogenase (NAD+) activity
D1095_04465	COG0243	molybdopterin cofactor binding
D1095_04470	COG0437	4 iron, 4 sulfur cluster binding
D1095_04475	COG2864	formate dehydrogenase
D1095_04480	COG3058	Necessary for formate dehydrogenase activity
D1095_04510	COG1560	Kdo2-lipid A biosynthetic process
D1095_04515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1095_04525	COG0302	gtp cyclohydrolase
D1095_04530	COG3642	lipopolysaccharide core region biosynthetic process
D1095_04540	COG0110	maltose O-acetyltransferase activity
D1095_04555	COG0583	DNA-binding transcription factor activity
D1095_04575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1095_04585	COG0215	cysteine-tRNA ligase activity
D1095_04590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1095_04595	COG0617	tRNA 3'-terminal CCA addition
D1095_04625	COG2975	iron-sulfur cluster assembly
D1095_04630	COG0633	Ferredoxin
D1095_04650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1095_04660	COG0822	iron-sulfur transferase activity
D1095_04665	COG1104	cysteine desulfurase activity
D1095_04670	COG1959	2 iron, 2 sulfur cluster binding
D1095_04680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1095_04685	COG0784	Response regulator, receiver
D1095_04685	COG5002	protein histidine kinase activity
D1095_04685	COG2198	Histidine kinase
D1095_04690	COG0697	spore germination
D1095_04695	COG2840	Smr protein MutS2
D1095_04700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1095_04705	COG2226	methyltransferase
D1095_04710	COG2830	Protein of unknown function (DUF452)
D1095_04715	COG0156	8-amino-7-oxononanoate synthase activity
D1095_04720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1095_04730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1095_04735	COG2027	D-alanyl-D-alanine carboxypeptidase
D1095_04750	COG2801	Transposase and inactivated derivatives
D1095_04770	COG2856	Zn peptidase
D1095_04775	COG3620	sequence-specific DNA binding
D1095_04810	COG1444	tRNA N-acetyltransferase activity
D1095_04815	COG0138	bifunctional purine biosynthesis protein purh
D1095_04840	COG3210	domain, Protein
D1095_04845	COG2831	hemolysin activation secretion protein
D1095_04850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1095_04855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1095_04865	COG3078	GTPase activator activity
D1095_04870	COG2985	domain, Protein
D1095_04870	COG0569	domain protein
D1095_04875	COG0786	glutamate:sodium symporter activity
D1095_04890	COG2350	Protein conserved in bacteria
D1095_04895	COG1607	acyl-coa hydrolase
D1095_04910	COG3092	negative regulation of chromosome organization
D1095_04915	COG0037	tRNA processing
D1095_04920	COG2056	Na+-H+ antiporter family
D1095_04925	COG0708	Exodeoxyribonuclease III
D1095_04930	COG0583	DNA-binding transcription factor activity
D1095_04950	COG0254	rRNA binding
D1095_04965	COG0753	catalase activity
D1095_04975	COG1408	metallophosphoesterase
D1095_04980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1095_04985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1095_04990	COG1085	galactose-1-phosphate uridylyltransferase
D1095_04995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1095_05000	COG2017	converts alpha-aldose to the beta-anomer
D1095_05020	COG0489	protein tyrosine kinase activity
D1095_05030	COG2095	MarC family integral membrane protein
D1095_05035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1095_05045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1095_05050	COG2354	Protein conserved in bacteria
D1095_05055	COG3071	HemY protein
D1095_05060	COG2959	enzyme of heme biosynthesis
D1095_05070	COG0181	hydroxymethylbilane synthase activity
D1095_05075	COG1012	belongs to the aldehyde dehydrogenase family
D1095_05075	COG1454	alcohol dehydrogenase
D1095_05085	COG4382	Mu-like prophage protein Gp16
D1095_05105	COG4396	Host-nuclease inhibitor protein Gam
D1095_05115	COG3267	Type II secretory pathway component ExeA
D1095_05115	COG3409	Peptidoglycan-binding domain 1 protein
D1095_05200	COG4373	Mu-like prophage FluMu protein gp28
D1095_05290	COG3392	D12 class N6 adenine-specific DNA methyltransferase
D1095_05305	COG0813	purine-nucleoside phosphorylase activity
D1095_05315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1095_05320	COG2364	Membrane
D1095_05325	COG0800	Aldolase
D1095_05330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1095_05350	COG2186	Transcriptional regulator
D1095_05360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1095_05360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1095_05365	COG1216	Glycosyl transferase, family 2
D1095_05370	COG1216	Glycosyl transferase, family 2
D1095_05380	COG3306	glycosyltransferase involved in LPS biosynthesis
D1095_05390	COG5039	Polysaccharide pyruvyl transferase
D1095_05395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1095_05400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1095_05405	COG1605	Chorismate mutase
D1095_05405	COG0077	Prephenate dehydratase
D1095_05410	COG0339	signal peptide processing
D1095_05415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1095_05420	COG1882	Formate acetyltransferase
D1095_05425	COG2116	formate transmembrane transporter activity
D1095_05430	COG1238	metal cluster binding
D1095_05435	COG0501	Belongs to the peptidase M48B family
D1095_05440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1095_05445	COG2431	L-lysine efflux transmembrane transporter activity
D1095_05450	COG1169	isochorismate synthase
D1095_05455	COG0436	Aminotransferase
D1095_05465	COG2962	Rard protein
D1095_05470	COG1280	lysine exporter protein (LysE YggA)
D1095_05475	COG4771	TonB-dependent receptor
D1095_05475	COG1629	transport
D1095_05480	COG0748	coenzyme F420 binding
D1095_05490	COG4235	cytochrome complex assembly
D1095_05490	COG3088	subunit of a heme lyase
D1095_05495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1095_05500	COG1138	Cytochrome C-type biogenesis protein
D1095_05505	COG0475	glutathione-regulated potassium exporter activity
D1095_05505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1095_05515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1095_05525	COG3111	PFAM Bacterial OB fold (BOF) protein
D1095_05540	COG0745	RESPONSE REGULATOR receiver
D1095_05545	COG0642	Histidine kinase
D1095_05550	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D1095_05555	COG1862	Preprotein translocase
D1095_05560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1095_05565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1095_05570	COG1528	Iron-storage protein
D1095_05575	COG1528	Iron-storage protein
D1095_05580	COG2252	PERMEase
D1095_05585	COG0424	maF-like protein
D1095_05595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1095_05595	COG0301	tRNA thio-modification
D1095_05605	COG0330	HflC and HflK could
D1095_05610	COG0330	HflC and HflK could
D1095_05615	COG3118	belongs to the thioredoxin family
D1095_05635	COG0531	amino acid
D1095_05640	COG0531	amino acid
D1095_05655	COG3047	cAMP biosynthetic process
D1095_05660	COG0542	response to heat
D1095_05665	COG0798	PFAM Bile acid sodium symporter
D1095_05670	COG1393	Belongs to the ArsC family
D1095_05680	COG1027	Aspartate ammonia-lyase
D1095_05690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1095_05695	COG3583	domain protein
D1095_05695	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1095_05695	COG3064	Membrane
D1095_05705	COG0720	synthase
D1095_05710	COG0602	queuosine metabolic process
D1095_05735	COG0795	lipopolysaccharide-transporting ATPase activity
D1095_05740	COG0795	lipopolysaccharide-transporting ATPase activity
D1095_05765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D1095_05785	COG0861	Integral membrane protein TerC family
D1095_05790	COG1472	Belongs to the glycosyl hydrolase 3 family
D1095_05800	COG0148	phosphopyruvate hydratase activity
D1095_05805	COG1051	belongs to the nudix hydrolase family
D1095_05810	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
D1095_05820	COG1965	Belongs to the frataxin family
D1095_05835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1095_05840	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1095_05845	COG0564	pseudouridine synthase activity
D1095_05855	COG0205	6-phosphofructokinase activity
D1095_05860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1095_05865	COG1525	nuclease
D1095_05870	COG1115	amino acid carrier protein
D1095_05875	COG0628	permease
D1095_05885	COG0826	peptidase U32
D1095_05890	COG3307	-O-antigen
D1095_05895	COG1519	Transferase
D1095_05900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1095_05905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1095_05910	COG0802	atpase or kinase
D1095_05915	COG1388	LysM domain
D1095_05915	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1095_05920	COG0166	Belongs to the GPI family
D1095_05925	COG2960	long-chain fatty acid transporting porin activity
D1095_05950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1095_05960	COG0551	DNA topoisomerase type I activity
D1095_05970	COG2137	regulation of response to DNA damage stimulus
D1095_05975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1095_05980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1095_05990	COG1322	Protein conserved in bacteria
D1095_05995	COG0512	Glutamine amidotransferase of anthranilate synthase
D1095_06005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1095_06010	COG0494	nUDIX hydrolase
D1095_06015	COG0217	transcriptional regulatory protein
D1095_06025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1095_06030	COG0612	Peptidase, M16
D1095_06035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1095_06040	COG0471	metal ion transport
D1095_06045	COG0583	DNA-binding transcription factor activity
D1095_06050	COG3266	domain, Protein
D1095_06055	COG1187	pseudouridine synthase activity
D1095_06060	COG0009	L-threonylcarbamoyladenylate synthase
D1095_06070	COG2837	iron assimilation
D1095_06075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1095_06080	COG0512	Glutamine amidotransferase of anthranilate synthase
D1095_06090	COG2226	methyltransferase
D1095_06095	COG2268	Band 7 protein
D1095_06100	COG2841	Protein conserved in bacteria
D1095_06105	COG0359	binds to the 23S rRNA
D1095_06115	COG2965	DNA replication, synthesis of RNA primer
D1095_06130	COG3201	nicotinamide mononucleotide transporter
D1095_06135	COG2976	Protein conserved in bacteria
D1095_06145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D1095_06150	COG1426	Protein conserved in bacteria
D1095_06155	COG0659	secondary active sulfate transmembrane transporter activity
D1095_06165	COG0673	inositol 2-dehydrogenase activity
D1095_06170	COG0475	glutathione-regulated potassium exporter activity
D1095_06170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1095_06210	COG1902	pentaerythritol trinitrate reductase activity
D1095_06215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D1095_06220	COG2084	Dehydrogenase
D1095_06225	COG0778	Nitroreductase
D1095_06230	COG2095	MarC family integral membrane protein
D1095_06245	COG0625	glutathione transferase activity
D1095_06260	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1095_06265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1095_06280	COG1275	C4-dicarboxylate transporter malic acid transport protein
D1095_06285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1095_06300	COG1132	(ABC) transporter
D1095_06305	COG1854	S-ribosylhomocysteine lyase activity
D1095_06310	COG3008	intermembrane lipid transfer
D1095_06315	COG0735	belongs to the Fur family
D1095_06320	COG0716	FMN binding
D1095_06330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1095_06335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1095_06340	COG2252	PERMEase
D1095_06345	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1095_06350	COG2081	HI0933 family
D1095_06355	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1095_06365	COG0560	Phosphoserine phosphatase
D1095_06370	COG1666	GTP binding
D1095_06375	COG0058	SHG alpha-glucan phosphorylase activity
D1095_06380	COG2909	trisaccharide binding
D1095_06390	COG4580	involved in the transport of maltose and maltodextrins
D1095_06395	COG3842	ATPase activity
D1095_06410	COG3833	ABC-type maltose transport systems, permease component
D1095_06415	COG1640	4-alpha-glucanotransferase
D1095_06420	COG1966	Carbon starvation protein
D1095_06425	COG0084	hydrolase, TatD family'
D1095_06430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1095_06440	COG0778	Nitroreductase
D1095_06455	COG4172	Belongs to the ABC transporter superfamily
D1095_06460	COG0191	fructose-bisphosphate aldolase activity
D1095_06465	COG0126	phosphoglycerate kinase activity
D1095_06470	COG0471	metal ion transport
D1095_06475	COG0471	metal ion transport
D1095_06480	COG0471	metal ion transport
D1095_06485	COG0187	DNA topoisomerase II activity
D1095_06490	COG5002	protein histidine kinase activity
D1095_06495	COG0745	RESPONSE REGULATOR receiver
D1095_06520	COG0789	Transcriptional regulator
D1095_06540	COG0300	oxidoreductase activity
D1095_06545	COG0778	Nitroreductase
D1095_06550	COG0616	signal peptide processing
D1095_06555	COG3719	Belongs to the RNase T2 family
D1095_06565	COG1252	NADH dehydrogenase
D1095_06570	COG2183	response to ionizing radiation
D1095_06575	COG3063	Type IV pilus biogenesis stability protein PilW
D1095_06580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1095_06610	COG2161	toxin-antitoxin pair type II binding
D1095_06615	COG4115	mRNA cleavage
D1095_06620	COG2835	tetraacyldisaccharide 4'-kinase activity
D1095_06625	COG1663	tetraacyldisaccharide 4'-kinase activity
D1095_06630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1095_06640	COG2166	iron-sulfur cluster assembly
D1095_06660	COG0488	(ABC) transporter
D1095_06665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1095_06680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1095_06685	COG5007	Belongs to the BolA IbaG family
D1095_06695	COG2854	intermembrane phospholipid transfer
D1095_06700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1095_06705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1095_06710	COG1127	ABC transporter
D1095_06715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1095_06720	COG1090	epimerase
D1095_06740	COG0563	adenylate kinase activity
D1095_06750	COG2814	Major facilitator Superfamily
D1095_06780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1095_06790	COG1794	racemase activity, acting on amino acids and derivatives
D1095_06795	COG2814	Major facilitator Superfamily
D1095_06800	COG0363	glucosamine-6-phosphate deaminase activity
D1095_06805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1095_06810	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1095_06815	COG0494	nUDIX hydrolase
D1095_06820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1095_06825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D1095_06830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1095_06835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1095_06840	COG0549	Belongs to the carbamate kinase family
D1095_06855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D1095_06860	COG1178	ABC-type Fe3 transport system permease component
D1095_06865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_06870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1095_06875	COG2190	(PTS) system
D1095_06885	COG0210	DNA helicase
D1095_06890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1095_06895	COG0409	Hydrogenase expression formation protein
D1095_06900	COG0309	Hydrogenase expression formation protein (HypE)
D1095_06925	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D1095_06930	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D1095_06935	COG0437	4 iron, 4 sulfur cluster binding
D1095_06940	COG5557	Pfam Polysulphide reductase, NrfD
D1095_06945	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D1095_06950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D1095_06955	COG1773	rubredoxin
D1095_06960	COG0298	carbon dioxide binding
D1095_06965	COG0375	protein maturation
D1095_07000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1095_07005	COG0308	aminopeptidase N
D1095_07010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1095_07015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1095_07020	COG0295	cytidine deaminase activity
D1095_07025	COG2177	Part of the ABC transporter FtsEX involved in
D1095_07030	COG2884	Cell division ATP-binding protein ftsE
D1095_07035	COG0552	protein localization to endoplasmic reticulum
D1095_07040	COG0742	ribosomal rna small subunit methyltransferase
D1095_07045	COG3099	Belongs to the UPF0263 family
D1095_07050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1095_07060	COG4160	amino acid transport
D1095_07065	COG4215	(ABC) transporter
D1095_07070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1095_07075	COG1126	abc transporter atp-binding protein
D1095_07080	COG1881	PFAM PEBP family protein
D1095_07090	COG3620	sequence-specific DNA binding
D1095_07100	COG4232	protein-disulfide reductase activity
D1095_07105	COG3101	peptidyl-lysine hydroxylation
D1095_07115	COG3107	peptidoglycan biosynthetic process
D1095_07120	COG0792	nuclease activity
D1095_07125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1095_07155	COG1138	Cytochrome C-type biogenesis protein
D1095_07165	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1095_07170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1095_07175	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1095_07180	COG4133	protoheme IX ABC transporter activity
D1095_07185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1095_07230	COG3630	sodium ion export across plasma membrane
D1095_07240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D1095_07245	COG2824	Alkylphosphonate utilization operon protein PhnA
D1095_07250	COG1858	cytochrome C peroxidase
D1095_07255	COG1872	DUF167
D1095_07260	COG0762	integral membrane protein
D1095_07265	COG3171	Protein conserved in bacteria
D1095_07270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1095_07275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1095_07280	COG0416	fatty acid biosynthetic process
D1095_07285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1095_07290	COG1399	metal-binding, possibly nucleic acid-binding protein
D1095_07295	COG4137	Cytochrome C assembly protein
D1095_07300	COG4536	flavin adenine dinucleotide binding
D1095_07305	COG0733	neurotransmitter:sodium symporter activity
D1095_07315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_07315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1095_07320	COG3715	PTS system
D1095_07325	COG3716	PTS system mannose fructose sorbose family IID component
D1095_07360	COG1840	ABC-type Fe3 transport system, periplasmic component
D1095_07375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1095_07390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1095_07390	COG0678	peroxiredoxin activity
D1095_07395	COG0583	DNA-binding transcription factor activity
D1095_07400	COG1309	transcriptional regulator
D1095_07405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1095_07410	COG0557	exoribonuclease II activity
D1095_07420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1095_07425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1095_07435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1095_07485	COG1216	Glycosyl transferase, family 2
D1095_07485	COG1442	glycosyl transferase family 8
D1095_07495	COG0438	transferase activity, transferring glycosyl groups
D1095_07500	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D1095_07510	COG1575	Belongs to the MenA family. Type 1 subfamily
D1095_07520	COG1720	tRNA m6t6A37 methyltransferase activity
D1095_07530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1095_07545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1095_07550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1095_07555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1095_07570	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D1095_07575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1095_07580	COG1755	Isoprenylcysteine carboxyl methyltransferase
D1095_07590	COG1530	ribonuclease E activity
D1095_07605	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1095_07610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1095_07620	COG0243	molybdopterin cofactor binding
D1095_07625	COG0437	4 iron, 4 sulfur cluster binding
D1095_07630	COG0348	domain, Protein
D1095_07635	COG3043	anaerobic respiration
D1095_07640	COG3005	denitrification pathway
D1095_07650	COG2050	protein possibly involved in aromatic compounds catabolism
D1095_07655	COG0277	FAD linked oxidase domain protein
D1095_07655	COG0247	lactate metabolic process
D1095_07660	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1095_07660	COG2885	chlorophyll binding
D1095_07665	COG1879	ABC-type sugar transport system periplasmic component
D1095_07670	COG1129	ABC transporter
D1095_07675	COG4211	Belongs to the binding-protein-dependent transport system permease family
D1095_07700	COG1022	Amp-dependent synthetase and ligase
D1095_07705	COG4989	oxidoreductase activity
D1095_07710	COG3691	Protein conserved in bacteria
D1095_07715	COG0814	amino acid
D1095_07735	COG4974	Belongs to the 'phage' integrase family
D1095_07740	COG0732	type I restriction modification DNA specificity domain
D1095_07765	COG1555	photosystem II stabilization
D1095_07770	COG3266	domain, Protein
D1095_07770	COG3061	Opacity-associated protein A
D1095_07780	COG0859	PFAM glycosyl transferase family 9
D1095_07785	COG0859	PFAM glycosyl transferase family 9
D1095_07790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1095_07795	COG0049	tRNA binding
D1095_07800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1095_07805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1095_07810	COG1045	serine acetyltransferase
D1095_07815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1095_07825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1095_07830	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1095_07835	COG1652	LysM domain
D1095_07840	COG2927	DNA polymerase III (CHI subunit)
D1095_07845	COG2153	protein acetylation
D1095_07865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1095_07870	COG1803	Methylglyoxal synthase
D1095_07875	COG1289	transmembrane transporter activity
D1095_07890	COG0783	Belongs to the Dps family
D1095_07915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D1095_07920	COG0204	Acyl-transferase
D1095_07930	COG0825	malonyl-CoA metabolic process
D1095_07950	COG2801	Transposase and inactivated derivatives
D1095_07970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1095_07995	COG1072	(Pantothenic acid kinase))
D1095_08000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1095_08015	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1095_08025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1095_08035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1095_08050	COG0625	glutathione transferase activity
D1095_08055	COG0019	diaminopimelate decarboxylase activity
D1095_08065	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D1095_08070	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D1095_08075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1095_08080	COG1053	succinate dehydrogenase
D1095_08085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D1095_08095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1095_08100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1095_08110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1095_08120	COG2264	protein methyltransferase activity
D1095_08150	COG4974	Belongs to the 'phage' integrase family
D1095_08205	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D1095_08220	COG1151	hydroxylamine reductase activity
D1095_08225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1095_08230	COG2244	polysaccharide biosynthetic process
D1095_08235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1095_08245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1095_08250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D1095_08255	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D1095_08275	COG0728	peptidoglycan biosynthetic process
D1095_08280	COG0268	Binds directly to 16S ribosomal RNA
D1095_08285	COG0569	domain protein
D1095_08290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1095_08295	COG3276	selenocysteine insertion sequence binding
D1095_08300	COG1921	L-seryl-tRNASec selenium transferase activity
D1095_08310	COG0716	FMN binding
D1095_08335	COG1629	transport
D1095_08335	COG4771	TonB-dependent receptor
D1095_08360	COG2431	L-lysine efflux transmembrane transporter activity
D1095_08400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1095_08430	COG1119	ATPase activity
D1095_08435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1095_08445	COG1739	Uncharacterized protein family UPF0029
D1095_08450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1095_08455	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D1095_08460	COG1970	mechanosensitive ion channel activity
D1095_08465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1095_08470	COG0321	lipoyl(octanoyl) transferase activity
D1095_08475	COG2921	Belongs to the UPF0250 family
D1095_08480	COG1686	Belongs to the peptidase S11 family
D1095_08485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1095_08490	COG0772	Belongs to the SEDS family
D1095_08495	COG0768	penicillin binding
D1095_08500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1095_08505	COG0799	negative regulation of ribosome biogenesis
D1095_08515	COG1126	abc transporter atp-binding protein
D1095_08525	COG3681	Belongs to the UPF0597 family
D1095_08530	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D1095_08540	COG3691	Protein conserved in bacteria
D1095_08585	COG0832	Belongs to the urease beta subunit family
D1095_08590	COG0831	urea catabolic process
D1095_08600	COG1122	ATPase activity
D1095_08605	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D1095_08610	COG0310	cobalt ion transport
D1095_08615	COG0310	cobalt ion transport
D1095_08620	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D1095_08625	COG0583	DNA-binding transcription factor activity
D1095_08635	COG0490	domain, Protein
D1095_08635	COG0471	metal ion transport
D1095_08640	COG3722	fumarate hydratase activity
D1095_08655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1095_08660	COG1349	DNA-binding transcription factor activity
D1095_08675	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
D1095_08680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1095_08685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1095_08690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1095_08695	COG2900	Belongs to the SlyX family
D1095_08700	COG0545	Peptidyl-prolyl cis-trans isomerase
D1095_08705	COG2964	Protein conserved in bacteria
D1095_08710	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1095_08720	COG2168	tRNA wobble position uridine thiolation
D1095_08755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1095_08760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1095_08765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1095_08770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1095_08795	COG0357	Ribosomal RNA small subunit methyltransferase G
D1095_08800	COG0445	tRNA wobble uridine modification
D1095_08805	COG0561	phosphatase activity
D1095_08810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1095_08815	COG3012	SEC-C Motif Domain Protein
D1095_08825	COG3716	PTS system mannose fructose sorbose family IID component
D1095_08830	COG3715	PTS system
D1095_08835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1095_08835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1095_08840	COG2610	gluconate transmembrane transporter activity
D1095_08845	COG3265	gluconokinase activity
D1095_08850	COG1609	Transcriptional regulator
D1095_08855	COG1609	Transcriptional regulator
D1095_08860	COG1869	D-ribose catabolic process
D1095_08870	COG1172	Belongs to the binding-protein-dependent transport system permease family
D1095_08875	COG1879	ABC-type sugar transport system periplasmic component
D1095_08880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1095_08885	COG0243	molybdopterin cofactor binding
D1095_08890	COG0437	4 iron, 4 sulfur cluster binding
D1095_08895	COG3302	dmso reductase anchor subunit
D1095_08900	COG3381	protein complex oligomerization
D1095_08905	COG2221	Nitrite and sulphite reductase 4Fe-4S
D1095_08905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1095_08935	COG1349	DNA-binding transcription factor activity
D1095_08940	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
D1095_08945	COG1070	Carbohydrate kinase
D1095_08950	COG4154	Belongs to the RbsD FucU family
D1095_08955	COG0235	Class ii aldolase
D1095_08960	COG0738	Major facilitator superfamily
D1095_08965	COG1454	alcohol dehydrogenase
D1095_08970	COG3477	response to acidic pH
D1095_08975	COG0765	amino acid transport
D1095_08985	COG1126	abc transporter atp-binding protein
D1095_08990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1095_09010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D1095_09035	COG3623	hexulose-6-phosphate isomerase
D1095_09040	COG0235	Class ii aldolase
D1095_09045	COG0545	Peptidyl-prolyl cis-trans isomerase
D1095_09065	COG4783	chaperone-mediated protein folding
D1095_09070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1095_09080	COG0758	DNA mediated transformation
D1095_09085	COG1297	OPT oligopeptide transporter protein
D1095_09100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1095_09110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1095_09115	COG0081	regulation of translation
D1095_09120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1095_09125	COG0222	ribosome binding
D1095_09170	COG0827	DNA restriction-modification system
D1095_09185	COG1487	ribonuclease activity
D1095_09205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D1095_09210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D1095_09220	COG0346	lactoylglutathione lyase activity
D1095_09225	COG1194	a g-specific adenine glycosylase
D1095_09230	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D1095_09235	COG0741	lytic transglycosylase activity
D1095_09265	COG0305	Participates in initiation and elongation during chromosome replication
D1095_09320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1095_09335	COG0737	Belongs to the 5'-nucleotidase family
D1095_09340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1095_09345	COG0606	chelatase, subunit chli
D1095_09355	COG2267	carboxylic ester hydrolase activity
D1095_09360	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D1095_09370	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D1095_09380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1095_09390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1095_09405	COG0051	transcription antitermination factor activity, RNA binding
D1095_09410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1095_09415	COG0088	Forms part of the polypeptide exit tunnel
D1095_09420	COG0089	rRNA binding
D1095_09425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1095_09430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1095_09435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1095_09440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1095_09445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1095_09450	COG0255	Belongs to the universal ribosomal protein uL29 family
D1095_09455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1095_09465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1095_09470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1095_09475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1095_09480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1095_09485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1095_09490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1095_09495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1095_09500	COG1841	ribosomal large subunit assembly
D1095_09505	COG0200	Binds to the 23S rRNA
D1095_09510	COG0201	protein transport
D1095_09520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1095_09525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1095_09530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1095_09535	COG0202	RNA polymerase activity
D1095_09545	COG0228	four-way junction DNA binding
D1095_09550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1095_09555	COG0336	Belongs to the RNA methyltransferase TrmD family
D1095_09560	COG0335	large ribosomal subunit rRNA binding
D1095_09565	COG2850	peptidyl-arginine hydroxylation
D1095_09570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1095_09575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1095_09620	COG2852	Protein conserved in bacteria
D1095_09645	COG2832	Protein of unknown function (DUF454)
D1095_09655	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1095_09665	COG0084	hydrolase, TatD family'
D1095_09685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1095_09695	COG0470	DNA polymerase III
D1095_09700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1095_09705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1095_09720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1095_09725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1095_09730	COG0254	rRNA binding
D1095_09735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1095_09740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1095_09745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1095_09750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1095_09760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1095_09775	COG0442	prolyl-tRNA aminoacylation
D1095_09785	COG1595	DNA-templated transcription, initiation
D1095_09790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1095_09800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1095_09825	COG2502	aspartate--ammonia ligase
D1095_09830	COG1522	sequence-specific DNA binding
D1095_09835	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D1095_09840	COG3161	chorismate lyase activity
D1095_09875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1095_09900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D1095_09910	COG4208	sulfate ABC transporter
D1095_09915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1095_09920	COG1304	FMN binding
D1095_09930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1095_09940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1095_09945	COG2995	paraquat-inducible protein a
D1095_09950	COG1305	Transglutaminase-like
D1095_09960	COG2608	mercury ion transmembrane transporter activity
D1095_09970	COG0583	DNA-binding transcription factor activity
D1095_09975	COG2171	N-acyltransferase activity
D1095_09980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1095_09990	COG0511	ligase activity, forming carbon-carbon bonds
D1095_09995	COG0439	Biotin carboxylase
D1095_10005	COG3084	Protein conserved in bacteria
D1095_10010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1095_10015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1095_10015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1095_10025	COG1876	peptidase activity
D1095_10030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1095_10035	COG1393	Belongs to the ArsC family
D1095_10045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1095_10050	COG0564	pseudouridine synthase activity
D1095_10060	COG0668	transmembrane transport
D1095_10065	COG0439	Biotin carboxylase
D1095_10075	COG1025	Belongs to the peptidase M16 family
D1095_10080	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D1095_10105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1095_10110	COG1067	ATP-dependent peptidase activity
D1095_10115	COG3120	sequence-specific DNA binding
D1095_10120	COG0180	Tryptophanyl-tRNA synthetase
D1095_10145	COG0730	response to heat
D1095_10160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1095_10170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1095_10175	COG2116	formate transmembrane transporter activity
D1095_10200	COG0443	Heat shock 70 kDa protein
D1095_10205	COG1070	Carbohydrate kinase
D1095_10210	COG2115	Belongs to the xylose isomerase family
D1095_10215	COG4213	ABC transporter substrate-binding protein
D1095_10220	COG1129	ABC transporter
D1095_10225	COG4214	carbohydrate transport
D1095_10230	COG2207	Transcriptional regulator
D1095_10230	COG1609	Transcriptional regulator
D1095_10235	COG3590	peptidase
D1095_10245	COG4145	pantothenate transmembrane transporter activity
D1095_10250	COG3924	membrane
D1095_10255	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D1095_10260	COG2853	Lipoprotein
D1095_10265	COG0676	glucose-6-phosphate 1-epimerase activity
D1095_10280	COG0726	polysaccharide deacetylase
D1095_10280	COG1649	PFAM Uncharacterised BCR, COG1649
D1095_10285	COG1215	transferase activity, transferring glycosyl groups
D1095_10295	COG0149	triose-phosphate isomerase activity
D1095_10305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1095_10310	COG1238	metal cluster binding
D1095_10325	COG1388	LysM domain
D1095_10325	COG4942	peptidase
D1095_10330	COG2818	Glycosylase
D1095_10340	COG0700	Nucleoside recognition
D1095_10345	COG3366	ferrous iron transmembrane transporter activity
D1095_10355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1095_10360	COG0594	ribonuclease P activity
D1095_10365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1095_10370	COG0174	glutamine synthetase
D1095_10375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D1095_10380	COG0494	nUDIX hydrolase
D1095_10410	COG1490	D-aminoacyl-tRNA deacylase activity
D1095_10415	COG1295	ribonuclease BN
D1095_10420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1095_10445	COG1064	alcohol dehydrogenase
D1095_10455	COG1923	regulation of RNA biosynthetic process
D1095_10460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1095_10465	COG1611	Belongs to the LOG family
D1095_10470	COG1694	Mazg nucleotide pyrophosphohydrolase
D1095_10485	COG1309	transcriptional regulator
D1095_10495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1095_10500	COG2003	Belongs to the UPF0758 family
D1095_10505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1095_10510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1095_10525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1095_10530	COG0076	glutamate decarboxylase activity
D1095_10535	COG0425	Belongs to the sulfur carrier protein TusA family
D1095_10540	COG2391	methyltransferase activity
D1095_10545	COG3085	chromosome segregation
D1095_10565	COG0598	Magnesium transport protein CorA
D1095_10570	COG2226	methyltransferase
D1095_10585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1095_10590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1095_10595	COG0805	protein transport
D1095_10615	COG1114	Component of the transport system for branched-chain amino acids
D1095_10620	COG1028	Short-chain dehydrogenase reductase Sdr
D1095_10625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1095_10630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1095_10635	COG0142	geranyltranstransferase activity
D1095_10645	COG0431	NADPH-dependent FMN reductase
D1095_10650	COG2259	Doxx family
D1095_10655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1095_10660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1095_10665	COG0697	spore germination
D1095_10670	COG4783	chaperone-mediated protein folding
D1095_10680	COG1040	competence protein
D1095_10685	COG2813	Specifically methylates the guanine in position
D1095_10695	COG0456	acetyltransferase
D1095_10700	COG0513	Belongs to the DEAD box helicase family
D1095_10710	COG0747	negative chemotaxis
D1095_10720	COG1584	GPR1 FUN34 yaaH family protein
D1095_10725	COG1120	ATPase activity
D1095_10730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1095_10735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1095_10760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1095_10765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1095_10795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1095_10815	COG0140	phosphoribosyl-ATP diphosphatase activity
D1095_10815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1095_10820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D1095_10825	COG0024	Methionine aminopeptidase
D1095_10840	COG1621	beta-fructofuranosidase activity
D1095_10845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1095_10855	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1095_10860	COG1136	(ABC) transporter
D1095_10865	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1095_10870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family