locus-tag	class	description
APL_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
APL_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
APL_0003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
APL_0004	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
APL_0005	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
APL_0007	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APL_0008	ENOG4105ERU	peptidase
APL_0009	ENOG4108V6E	Cell division protein mraZ
APL_0010	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
APL_0012	ENOG4105CJN	penicillin-binding protein
APL_0013	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
APL_0014	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
APL_0015	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
APL_0016	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
APL_0017	ENOG4105CNI	cell division protein FtsW
APL_0018	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
APL_0019	ENOG4105DFU	Cell wall formation (By similarity)
APL_0020	ENOG4105CPF	Cell wall formation (By similarity)
APL_0022	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
APL_0023	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
APL_0024	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APL_0025	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
APL_0026	ENOG4108JQ5	ABC transporter
APL_0027	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APL_0028	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
APL_0030	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
APL_0033	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
APL_0034	ENOG4105C3G	gtp-binding protein
APL_0037	ENOG4108XTF	Outer Membrane Lipoprotein
APL_0038	ENOG4105NBI	YecM protein
APL_0039	ENOG4105C75	arginyL-tRNA synthetase
APL_0040	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APL_0041	ENOG4105WV0	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
APL_0042	ENOG4105C2N	RNA methyltransferase TrmH family group 3
APL_0043	ENOG4105JIM	Phosphatidylserine synthase
APL_0044	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
APL_0045	ENOG4105DTN	riboflavin biosynthesis protein ribF
APL_0046	ENOG4107VZS	Nicotinamide-nucleotide adenylyltransferase
APL_0047	ENOG4108VVQ	metallophosphoesterase
APL_0048	ENOG41065U4	response regulator
APL_0051	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
APL_0052	ENOG4105DFA	alanine racemase domain protein
APL_0053	ENOG4105CI3	gtp-binding protein typa
APL_0054	ENOG41090BQ	Glutaredoxin
APL_0055	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
APL_0056	ENOG4105DSJ	YicC domain protein
APL_0057	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
APL_0058	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
APL_0059	ENOG4105WH1	Two component transcriptional regulator luxr family
APL_0060	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
APL_0061	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
APL_0062	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
APL_0063	ENOG4105DEF	Extracellular solute-binding protein, family 5
APL_0064	ENOG4105DEF	Extracellular solute-binding protein, family 5
APL_0065	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
APL_0066	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APL_0067	ENOG4105C3U	ABC transporter
APL_0068	ENOG4108JQ7	(ABC) transporter
APL_0071	ENOG4105M4H	endoribonuclease L-psp
APL_0072	ENOG4105CM2	brancheD-chain amino acid aminotransferase
APL_0073	ENOG4105M2J	Glutaredoxin
APL_0074	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
APL_0075	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
APL_0077	ENOG4105M15	transport protein ExbD
APL_0078	ENOG4105M8K	biopolymer transport protein
APL_0079	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
APL_0080	ENOG4107QR8	Thioredoxin
APL_0081	ENOG4105VDH	Dihydroxyacetone kinase
APL_0082	ENOG4108UTZ	Dihydroxyacetone kinase
APL_0083	ENOG4105CMT	Dihydroxyacetone kinase
APL_0084	ENOG4105C3M	thioredoxin reductase
APL_0085	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
APL_0086	ENOG4105VP5	Bacterial protein of unknown function (DUF937)
APL_0088	ENOG4108R99	pseudouridine synthase
APL_0090	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
APL_0091	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
APL_0092	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
APL_0094	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
APL_0097	ENOG4105C01	Dihydroxy-acid dehydratase
APL_0098	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
APL_0100	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
APL_0101	ENOG4105JJ8	Cytochrome c nitrite reductase, pentaheme subunit
APL_0102	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
APL_0103	ENOG4105DVI	reductase, NrfD
APL_0104	ENOG4105EUR	Domain-Containing protein
APL_0104	ENOG4105EUR	Domain-Containing protein
APL_0104	ENOG4105EUR	Domain-Containing protein
APL_0104	ENOG4105EUR	Domain-Containing protein
APL_0105	ENOG4105C2W	permease
APL_0106	ENOG4105C26	Dehydrogenase
APL_0107	ENOG4105CK7	Sodium proline symporter
APL_0108	ENOG41069M3	Transcriptional regulator
APL_0109	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
APL_0111	ENOG4105E07	UPF0149 protein
APL_0112	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
APL_0113	ENOG4105R2J	Conserved Protein
APL_0114	ENOG4105K70	DNA-binding protein
APL_0115	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
APL_0117	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
APL_0118	ENOG4105VEQ	Cold shock protein
APL_0119	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
APL_0120	ENOG4105CN1	protease
APL_0121	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
APL_0122	ENOG4105EAQ	(twin-arginine translocation) pathway signal
APL_0123	ENOG4105C5X	domain protein
APL_0126	ENOG4105K59	histidine triad (HIT) protein
APL_0127	ENOG4105CC5	ABC transporter
APL_0128	ENOG4105CC5	ABC transporter
APL_0129	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
APL_0130	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
APL_0131	ENOG4105ETT	transcriptional Regulator, LysR family
APL_0132	ENOG4105PAD	Hydrolase
APL_0133	ENOG4107R11	Transcriptional regulator
APL_0135	ENOG4105HDK	L-asparaginase
APL_0136	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
APL_0138	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
APL_0139	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
APL_0140	ENOG4107VHA	regulatoR
APL_0141	ENOG4107QQ0	gntp family
APL_0142	ENOG4105BZW	Glycerate kinase
APL_0143	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
APL_0144	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
APL_0145	ENOG4105EWT	decarboxylase family
APL_0146	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
APL_0148	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APL_0149	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
APL_0150	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
APL_0151	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
APL_0152	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
APL_0153	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
APL_0154	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
APL_0155	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
APL_0156	ENOG4105CJ2	(LipO)protein
APL_0158	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
APL_0159	ENOG4105D8G	Major Facilitator superfamily
APL_0160	ENOG4105II7	pyrroline-5-carboxylate reductase
APL_0161	ENOG4105DH7	May be involved in recombination (By similarity)
APL_0162	ENOG4107VXZ	Hydrolase
APL_0165	ENOG4105DGN	Electron transport complex
APL_0166	ENOG4108R3D	Electron transport complex
APL_0167	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
APL_0168	ENOG4105EN6	Membrane
APL_0169	ENOG4105D6A	Electron transport complex
APL_0172	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
APL_0174	ENOG4105DP9	ABC transporter
APL_0175	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APL_0176	ENOG4105DJ0	Poly(A) Polymerase
APL_0177	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APL_0179	ENOG4107H52	Dicarboxylate transport
APL_0181	ENOG4108UYE	Lactoylglutathione lyase
APL_0182	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
APL_0183	ENOG4105K3M	)-transporter
APL_0184	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
APL_0185	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
APL_0186	ENOG4105DKP	glycosyl transferase, family 9
APL_0187	ENOG4105CA9	Pyruvate kinase
APL_0188	ENOG4108BY2	phosphohistidine phosphatase
APL_0189	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
APL_0190	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
APL_0191	ENOG4105C8J	)-transporter
APL_0192	ENOG4105DFE	Dna adenine methylase
APL_0193	ENOG4105D49	3-dehydroquinate synthase
APL_0194	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
APL_0195	ENOG4108JQC	penicillin-binding protein 1A
APL_0200	ENOG4105E4G	Type IV pilus
APL_0201	ENOG4107YIM	Involved in the transcription termination process (By similarity)
APL_0202	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
APL_0203	ENOG4108ZAI	phosphatidylglycerophosphatase a
APL_0204	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
APL_0205	ENOG4105EIB	trna rrna methyltransferase
APL_0206	ENOG4105ECY	inositol monophosphatase
APL_0207	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
APL_0208	ENOG4105DQ6	Transposase
APL_0209	ENOG4105DQ6	Transposase
APL_0210	ENOG4105IYK	transposase
APL_0211	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
APL_0212	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
APL_0219	ENOG4105C22	threonyL-tRNA synthetase
APL_0220	ENOG4106B0W	Curli production assembly transport component CsgG
APL_0222	ENOG4107Y60	(LipO)protein
APL_0223	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
APL_0224	ENOG41082NX	50s ribosomal protein l35
APL_0225	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
APL_0226	ENOG4108QD6	
APL_0228	ENOG4105C37	(CBS) domain
APL_0229	ENOG4108W1A	pseudouridine synthase
APL_0230	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
APL_0231	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
APL_0232	ENOG4108UJU	UPF0301 protein
APL_0233	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
APL_0235	ENOG4105M85	Bola protein
APL_0239	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
APL_0241	ENOG4105M6F	mutator MutT protein
APL_0242	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
APL_0243	ENOG4105CAS	nag kinase
APL_0244	ENOG4105C8Y	Acetylornithine aminotransferase
APL_0246	ENOG4108MVK	Receptor
APL_0247	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
APL_0248	ENOG4105C6T	cysteine synthase
APL_0249	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
APL_0250	ENOG4105CFH	Aspartokinase
APL_0251	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
APL_0252	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
APL_0253	ENOG4107QYX	exodeoxyribonuclease v alpha
APL_0254	ENOG4105CIN	aminoacyl-histidine dipeptidase
APL_0255	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
APL_0256	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
APL_0257	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
APL_0259	ENOG4108Z1B	Cyclase dehydrase
APL_0260	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
APL_0261	ENOG4105E0C	molybdate abc transporter
APL_0262	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
APL_0263	ENOG4105E3A	(ABC) transporter
APL_0264	ENOG4105DA5	(ABC) transporter
APL_0265	ENOG4107QMP	dna polymerase iii subunits gamma and tau
APL_0266	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
APL_0268	ENOG4105KME	endoribonuclease L-psp
APL_0269	ENOG4105C6T	cysteine synthase
APL_0270	ENOG4108KXH	Ybak prolyl-tRNA synthetase associated
APL_0271	ENOG4105DIK	(ABC) transporter
APL_0273	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
APL_0274	ENOG4108MN8	Membrane
APL_0275	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
APL_0277	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
APL_0278	ENOG4108RE7	deoxyribonuclease
APL_0279	ENOG4105C4R	Atp-dependent dna helicase
APL_0280	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APL_0281	ENOG4105F38	ABC transporter, permease
APL_0282	ENOG4105D38	putrescine abc transporter
APL_0283	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
APL_0285	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
APL_0286	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APL_0294	ENOG4105C5H	ABC transporter
APL_0295	ENOG4105CUZ	uba thif-type nad fad binding protein
APL_0297	ENOG4105C4M	(Ubiquinol oxidase) subunit I
APL_0298	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
APL_0299	ENOG4107YD3	Thioesterase
APL_0300	ENOG4105E02	MotA TolQ exbB proton channel
APL_0303	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
APL_0304	ENOG4105KCK	Peptidoglycan-associated lipoprotein
APL_0306	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
APL_0307	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
APL_0308	ENOG4106K28	UPF0283 membrane protein
APL_0309	ENOG4105C5H	ABC transporter
APL_0310	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
APL_0311	ENOG4105D06	uba thif-type nad fad binding protein
APL_0312	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
APL_0313	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
APL_0314	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
APL_0315	ENOG4105D3G	Pseudouridine synthase
APL_0316	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
APL_0317	ENOG4105D6S	protein involved in catabolism of external DNA
APL_0318	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
APL_0320	ENOG4105C28	cystathionine
APL_0321	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
APL_0322	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
APL_0324	ENOG4105C9A	Phoh family
APL_0326	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
APL_0327	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
APL_0329	ENOG4105D0A	hydroxylase
APL_0333	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
APL_0334	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
APL_0335	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
APL_0336	ENOG4108IUZ	ABC transporter
APL_0337	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
APL_0339	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
APL_0340	ENOG4108WV1	Pfam:DUF477
APL_0342	ENOG4108V0P	LemA family
APL_0343	ENOG4105DM4	PTS System
APL_0344	ENOG4105DE4	1-phosphofructokinase
APL_0345	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
APL_0347	ENOG4108ESZ	Glycogen debranching enzyme
APL_0348	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
APL_0349	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
APL_0350	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
APL_0351	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
APL_0352	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
APL_0354	ENOG4105I08	Pseudouridine synthase
APL_0355	ENOG4105C2C	drug resistance transporter, Bcr CflA
APL_0357	ENOG4107XHZ	cytoplasmic chaperone TorD family protein
APL_0358	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
APL_0359	ENOG4107TT5	NLP P60 protein
APL_0361	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
APL_0362	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
APL_0363	ENOG4108MJ5	VirK protein
APL_0365	ENOG4105CQ7	ATP-dependent helicase
APL_0366	ENOG4108VMM	UPF0756 membrane protein
APL_0367	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APL_0368	ENOG4107RUE	extracellular solute-binding protein family 1
APL_0369	ENOG4107QI1	Mate efflux family protein
APL_0370	ENOG4107QKA	exodeoxyribonuclease V beta
APL_0371	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
APL_0372	ENOG4108JU5	Magnesium and cobalt efflux protein
APL_0373	ENOG4108Q67	UPF0319 protein
APL_0374	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
APL_0375	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
APL_0376	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
APL_0377	ENOG4105CXY	transporter
APL_0378	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
APL_0379	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
APL_0380	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
APL_0381	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
APL_0382	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
APL_0383	ENOG4108R6K	riboflavin synthase, subunit alpha
APL_0384	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
APL_0385	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
APL_0386	ENOG4108RRZ	Transcription elongation factor GreB
APL_0387	ENOG4105C2X	Arabinose 5-phosphate isomerase
APL_0389	ENOG4105CUR	5'-nucleotidase, lipoprotein e(p4) family
APL_0390	ENOG4105C09	Bile acid
APL_0391	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
APL_0392	ENOG4105DQF	Hydrolase
APL_0393	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
APL_0394	ENOG4105EMN	RNA polymerase sigma factor
APL_0395	ENOG41069PW	sigma-e factor negative regulatory protein
APL_0397	ENOG4105CEY	Amp-dependent synthetase and ligase
APL_0398	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
APL_0399	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
APL_0400	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
APL_0401	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
APL_0402	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
APL_0403	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
APL_0404	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
APL_0405	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
APL_0406	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
APL_0407	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APL_0408	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
APL_0409	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APL_0411	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APL_0412	ENOG4105DZP	Membrane-associated zinc metalloprotease
APL_0413	ENOG4105KNE	Phosphatidate cytidylyltransferase
APL_0414	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
APL_0415	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
APL_0417	ENOG4105EYK	Phosphatidylglycerophosphatase B
APL_0418	ENOG4105HBR	Rna-binding protein
APL_0419	ENOG4106WTF	Glycosyl transferase, family 2
APL_0420	ENOG41061WM	D-Alanyl-D-Alanine
APL_0421	ENOG4105M5K	heptosyltransferase
APL_0423	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
APL_0424	ENOG4105E96	Colicin v production protein
APL_0425	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
APL_0427	ENOG4105D82	Glutamate dehydrogenase
APL_0428	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
APL_0429	ENOG4106V8H	Nucleoid-associated protein
APL_0430	ENOG4105KME	endoribonuclease L-psp
APL_0431	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
APL_0433	ENOG4105E0X	reductase
APL_0434	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
APL_0435	ENOG4105DFF	Rod shape-determining protein mreb
APL_0436	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
APL_0438	ENOG4105D1H	recombination factor protein RarA
APL_0439	ENOG4105FAV	ABC, transporter
APL_0440	ENOG4105E7A	Glutamine amidotransferase
APL_0441	ENOG4105DWV	Homoserine O-trans-acetylase
APL_0442	ENOG4107GZ4	SanA protein
APL_0444	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
APL_0445	ENOG4107QR9	Iron-sulfur cluster binding protein
APL_0446	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
APL_0447	ENOG4105DAA	L-lactate
APL_0448	ENOG4108SAU	DNA-binding protein H-ns
APL_0449	ENOG4107S6Z	Na H antiporter
APL_0450	ENOG4105EMA	Periplasmic binding protein LacI transcriptional regulator
APL_0451	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
APL_0452	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
APL_0453	ENOG4108MJ5	VirK protein
APL_0454	ENOG4105C7S	Dehydrogenase
APL_0455	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
APL_0456	ENOG4105FDK	ABC transporter
APL_0457	ENOG4105DR5	peptidase
APL_0458	ENOG4105T95	Thiol disulfide interChange protein
APL_0459	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
APL_0461	ENOG4108K4B	hydrolase
APL_0462	ENOG4105BZU	Histidine kinase
APL_0464	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
APL_0465	ENOG4105K8R	UPF0145 protein
APL_0466	ENOG4105CKU	formyltetrahydrofolate synthetase
APL_0467	ENOG4108ZZ3	UPF0260 protein
APL_0468	ENOG4105EMU	Dehydrogenase
APL_0469	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
APL_0470	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
APL_0471	ENOG4105X5T	
APL_0473	ENOG4105C2M	dna polymerase I
APL_0474	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
APL_0476	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
APL_0482	ENOG41080HT	Transcriptional regulator, arsr family
APL_0485	ENOG41080C8	DUF218 domain
APL_0486	ENOG4105C6K	Malic enzyme
APL_0487	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
APL_0502	ENOG4108MXB	Protein of unknown function (DUF968)
APL_0510	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
APL_0526	ENOG41065CD	Exported protein
APL_0527	ENOG4105D7X	high-affinity nickel-transporter
APL_0528	ENOG4105BZG	amino acid carrier protein
APL_0531	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
APL_0532	ENOG4105D06	uba thif-type nad fad binding protein
APL_0533	ENOG4105D06	uba thif-type nad fad binding protein
APL_0534	ENOG4105WHD	thiamine biosynthesis protein ThiS
APL_0535	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
APL_0536	ENOG4105D41	biosynthesis protein thiH
APL_0537	ENOG4105ETU	transcriptional activator (TenA
APL_0538	ENOG4107Z6I	Thiamine biosynthesis protein
APL_0539	ENOG4105DWF	phosphomethylpyrimidine kinase
APL_0541	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
APL_0542	ENOG4105C3F	Signal peptidase i
APL_0543	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
APL_0544	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
APL_0545	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
APL_0560	ENOG4105C1J	atp-dependent rna helicase
APL_0562	ENOG4105D7A	ATP-binding protein
APL_0563	ENOG4105C4Y	ABC transporter
APL_0564	ENOG4107RCV	ABC transporter, permease
APL_0565	ENOG4105CQ0	ABC transporter
APL_0566	ENOG4105CE9	30S ribosomal protein S2
APL_0567	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
APL_0568	ENOG4108I6E	Sulfatase
APL_0569	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
APL_0570	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
APL_0571	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
APL_0572	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
APL_0573	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
APL_0574	ENOG4108Z6B	deaminase
APL_0575	ENOG4105C1J	atp-dependent rna helicase
APL_0576	ENOG4105RT1	May be involved in cell division (By similarity)
APL_0577	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
APL_0578	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APL_0579	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
APL_0580	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
APL_0581	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
APL_0583	ENOG4105E68	Sulfatase
APL_0584	ENOG4105YDX	UPF0352 protein
APL_0585	ENOG4105Y7M	Transcriptional regulator, TetR family
APL_0586	ENOG410624X	efflux transporter, rnd family, mfp subunit
APL_0587	ENOG4105BZS	acriflavin resistance protein
APL_0588	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
APL_0590	ENOG4105TWJ	Domain of unknown function (DUF1919)
APL_0591	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
APL_0592	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
APL_0593	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
APL_0594	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
APL_0595	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APL_0596	ENOG4105E0U	tyrosine-specific transport protein
APL_0597	ENOG4105E0U	tyrosine-specific transport protein
APL_0599	ENOG4108W2Q	Cytochrome d ubiquinol oxidase subunit III
APL_0600	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
APL_0601	ENOG4108UJD	30S ribosomal protein S9
APL_0602	ENOG4105D1Q	UPF0246 protein
APL_0604	ENOG41076HS	cation diffusion facilitator family transporter
APL_0605	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
APL_0606	ENOG4107R6U	sodium dicarboxylate symporter
APL_0607	ENOG4108RCM	Nitroreductase
APL_0608	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
APL_0609	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
APL_0610	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
APL_0611	ENOG4108QBX	(LipO)protein
APL_0612	ENOG4105DQ6	Transposase
APL_0613	ENOG4105IYK	transposase
APL_0614	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
APL_0615	ENOG4105E2R	ROK family
APL_0616	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
APL_0617	ENOG4105EW9	transcriptional regulator AsnC family
APL_0618	ENOG4105CNU	cell division protein FtsK
APL_0619	ENOG4105CGZ	zinc metallopeptidase
APL_0620	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
APL_0621	ENOG41072GX	Peptidase M22 Glycoprotease
APL_0622	ENOG4107104	thymidine kinase
APL_0623	ENOG4105N4M	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
APL_0624	ENOG4105CBT	Fructose-1,6-bisphosphatase
APL_0625	ENOG4107QNR	UPF0135 protein
APL_0626	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
APL_0627	ENOG4105E0F	Histidine kinase
APL_0629	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
APL_0630	ENOG4105DXN	mazG family
APL_0631	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
APL_0632	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
APL_0633	ENOG4105CVR	type I restriction-modification system
APL_0634	ENOG4105EKX	Restriction modification system DNA (Specificity
APL_0636	ENOG4105DZR	Type I site-specific deoxyribonuclease
APL_0637	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
APL_0638	ENOG4105CHV	Transcription elongation factor NusA
APL_0639	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
APL_0640	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
APL_0641	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
APL_0642	ENOG4105CVE	Lytic murein transglycosylase
APL_0643	ENOG4107EPN	Domain of unknown function (DUF1508)
APL_0644	ENOG4108DNC	Involved in acetate metabolism (By similarity)
APL_0645	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
APL_0646	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
APL_0651	ENOG4108J3C	UTP-glucose-1-phosphate uridylyltransferase
APL_0653	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
APL_0654	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
APL_0656	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
APL_0657	ENOG4105KB2	stringent starvation protein b
APL_0658	ENOG4107MKT	Stringent starvation protein a
APL_0659	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
APL_0660	ENOG4105HDK	L-asparaginase
APL_0661	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
APL_0662	ENOG4105CGF	Aromatic amino acid aminotransferase
APL_0663	ENOG4107RAQ	aminopeptidase
APL_0667	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
APL_0668	ENOG410650H	(LipO)protein
APL_0669	ENOG4105DBE	peroxidase
APL_0671	ENOG4105DB7	PHP domain protein
APL_0673	ENOG4105CJB	Exodeoxyribonuclease I
APL_0675	ENOG4105C5S	asparaginyl-tRNA synthetase
APL_0676	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
APL_0678	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
APL_0679	ENOG4105CX6	glutaminyL-tRNA synthetase
APL_0680	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APL_0681	ENOG4107SC1	transglycosylase
APL_0682	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
APL_0683	ENOG4105C28	cystathionine
APL_0684	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
APL_0685	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
APL_0686	ENOG4105M08	Membrane
APL_0687	ENOG4105CXG	d-lactate dehydrogenase
APL_0688	ENOG4107QY8	reductase
APL_0689	ENOG4105CUW	cytochrome C-TYPE protein
APL_0690	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APL_0691	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APL_0692	ENOG4105M00	molybdopterin converting factor, subunit 1
APL_0693	ENOG4108ZAF	Molybdopterin
APL_0694	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
APL_0695	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
APL_0696	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
APL_0697	ENOG4105CC0	LysR family Transcriptional regulator
APL_0698	ENOG4108EKC	n-acetylglutamate synthase
APL_0699	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
APL_0702	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
APL_0703	ENOG4105C0D	helicase
APL_0706	ENOG4105QEK	Transcriptional regulator
APL_0707	ENOG4108R66	Conserved Protein
APL_0708	ENOG4105C9X	ppx gppa phosphatase
APL_0710	ENOG4105CFH	Aspartokinase
APL_0711	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
APL_0712	ENOG4105VNG	YcgL domain-containing protein
APL_0713	ENOG4105CDU	Replicative dna helicase
APL_0715	ENOG4105DHS	permease protein
APL_0716	ENOG4105CM4	permease protein
APL_0717	ENOG4108IPW	abc transporter atp-binding protein
APL_0718	ENOG4107IX6	phosphate transport regulator
APL_0719	ENOG4105CJ3	phosphate transporter
APL_0722	ENOG4105NSG	hemerythrin hhe cation binding domain protein
APL_0723	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
APL_0725	ENOG4105VEQ	Cold shock protein
APL_0726	ENOG41077A9	carbonic anhydrase
APL_0727	ENOG4105C7K	acetolactate synthase
APL_0728	ENOG4108ZP8	Acetolactate synthase small subunit
APL_0729	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
APL_0730	ENOG4105N42	UPF0307 protein
APL_0732	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
APL_0733	ENOG4108UQV	Membrane
APL_0734	ENOG4108ZPB	UPF0306 protein
APL_0735	ENOG4108ZJT	translation initiation factor, Sui1
APL_0736	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
APL_0737	ENOG4105CFV	Tetratricopeptide repeat protein
APL_0738	ENOG4105Q4A	inner membrane protein yciS
APL_0739	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
APL_0740	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
APL_0741	ENOG4105CAT	Cytidine monophosphate kinase
APL_0742	ENOG4105C0H	protease
APL_0744	ENOG4108IYH	Dna topoisomerase
APL_0747	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
APL_0748	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
APL_0749	ENOG4105EGS	Mechanosensitive ion channel
APL_0750	ENOG4105EGS	Mechanosensitive ion channel
APL_0751	ENOG4105CEY	Amp-dependent synthetase and ligase
APL_0752	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
APL_0753	ENOG4105EV9	Alpha Beta Hydrolase
APL_0754	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
APL_0755	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
APL_0757	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
APL_0758	ENOG4105VAW	lrga family
APL_0759	ENOG41067MG	lrgb family
APL_0760	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
APL_0762	ENOG4105DVA	methyltransferase
APL_0764	ENOG4105CHW	UPF0052 protein
APL_0765	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
APL_0766	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
APL_0767	ENOG4108IYC	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
APL_0768	ENOG41080IJ	Diacylglycerol kinase
APL_0769	ENOG4105CGH	5'-nucleotidase
APL_0771	ENOG4107QN2	dihydrolipoyl dehydrogenase
APL_0772	ENOG4107QSN	dihydrolipoamide acetyltransferase
APL_0773	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
APL_0774	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
APL_0775	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
APL_0776	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
APL_0778	ENOG4105BZ1	(ABC) transporter
APL_0779	ENOG41067MG	lrgb family
APL_0781	ENOG4105DVT	helicase
APL_0782	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
APL_0783	ENOG4108UUM	single-stranded DNA-binding protein
APL_0789	ENOG4105EA8	2-Nitropropane dioxygenase
APL_0792	ENOG4105UNS	Pfam:DUF419
APL_0793	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
APL_0794	ENOG4108EU3	peptide transport system, permease
APL_0796	ENOG4108EVY	peptide transport periplasmic protein
APL_0797	ENOG4108JU8	Transcriptional regulator
APL_0798	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
APL_0800	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
APL_0801	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
APL_0802	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
APL_0803	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
APL_0804	ENOG4105E0M	Sulfatase
APL_0805	ENOG4105QVC	MOSC domain-containing protein
APL_0807	ENOG4105CTB	Polyprenyl synthetase
APL_0809	ENOG4105CRK	lysyL-tRNA synthetase
APL_0810	ENOG4105C03	ribonuclease
APL_0811	ENOG4105DDY	UPF0142 protein ycaO
APL_0813	ENOG4107QMH	DNA methylase
APL_0814	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
APL_0816	ENOG4105CA3	membrane-bound lytic murein transglycosylase
APL_0818	ENOG4105VT2	5-hydroxyisourate hydrolase
APL_0819	ENOG4105ETE	Transcriptional regulator (LacI family
APL_0820	ENOG4108VD1	dedA family
APL_0821	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APL_0822	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
APL_0823	ENOG4105E98	transcriptional regulator DeoR family
APL_0824	ENOG4107QTF	adenylosuccinate lyase
APL_0825	ENOG41075W9	High frequency lysogenization protein HflD homolog
APL_0826	ENOG4108JJ8	(ABC) transporter
APL_0827	ENOG4108JJ9	ABC, transporter
APL_0828	ENOG4105MA0	exported protein
APL_0829	ENOG4105CFU	surface antigen
APL_0830	ENOG4105PXI	polysaccharide deacetylase
APL_0831	ENOG41063SB	peptidase
APL_0832	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
APL_0834	ENOG4105DBI	uridine monophosphokinase
APL_0835	ENOG4105DHP	deoxycytidine triphosphate deaminase
APL_0837	ENOG4105D0S	secretion protein (HlyD
APL_0838	ENOG4105CJ1	ABC, transporter
APL_0839	ENOG4105CMI	transporter
APL_0841	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
APL_0842	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
APL_0843	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
APL_0844	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
APL_0845	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
APL_0846	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APL_0847	ENOG4105CSA	Coproporphyrinogen iii oxidase
APL_0848	ENOG4107QSI	ABC, transporter
APL_0851	ENOG4108JQ7	(ABC) transporter
APL_0854	ENOG4105SYT	Methylenetetrahydrofolate reductase
APL_0855	ENOG4105DEF	Extracellular solute-binding protein, family 5
APL_0856	ENOG4105C44	Serine transporter
APL_0857	ENOG4105EJQ	L-serine dehydratase
APL_0858	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
APL_0859	ENOG4105DK0	Indole-3-glycerol phosphate synthase
APL_0861	ENOG4105WP7	tRNA pseudouridine synthase C
APL_0862	ENOG4105DR9	pseudouridine synthase
APL_0865	ENOG4105I7R	Adenylate cyclase
APL_0866	ENOG4105CM6	amino acid regulated cytosolic protein
APL_0867	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
APL_0868	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
APL_0869	ENOG4105CH2	amidohydrolase
APL_0871	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
APL_0872	ENOG4105C8T	Leucyl-tRNA synthetase
APL_0874	ENOG4105DJF	DNA polymerase III, delta' subunit
APL_0875	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
APL_0876	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
APL_0878	ENOG4105D7Q	type ii secretion system
APL_0879	ENOG4107QHF	type ii secretion system protein e
APL_0881	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
APL_0883	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
APL_0884	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
APL_0885	ENOG4105EJ9	Membrane
APL_0886	ENOG4105CSM	endonuclease III
APL_0891	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
APL_0892	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
APL_0893	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
APL_0894	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
APL_0895	ENOG4108MG3	formate dehydrogenase
APL_0896	ENOG4105F46	Necessary for formate dehydrogenase activity (By similarity)
APL_0897	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
APL_0899	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
APL_0900	ENOG4105D1S	lipid A biosynthesis
APL_0901	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
APL_0902	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
APL_0903	ENOG4105EUJ	GTP cyclohydrolase i
APL_0904	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
APL_0906	ENOG4108UW5	maltose o-acetyltransferase
APL_0907	ENOG4105ENX	hydrolase
APL_0908	ENOG4105EQ2	LysR family Transcriptional regulator
APL_0909	ENOG4105D01	(LipO)protein
APL_0910	ENOG4105D01	(LipO)protein
APL_0911	ENOG4108UMI	ABC transporter, permease
APL_0912	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
APL_0913	ENOG4105C8N	cysteinyl-tRNA synthetase
APL_0914	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
APL_0915	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APL_0916	ENOG4105IYK	transposase
APL_0917	ENOG4105DQ6	Transposase
APL_0918	ENOG4105DQ6	Transposase
APL_0919	ENOG4105UGU	tonB-dependent Receptor
APL_0923	ENOG4105WVQ	Fe-S assembly protein IscX
APL_0924	ENOG4108ZIT	Ferredoxin, 2FE-2S
APL_0925	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
APL_0926	ENOG4108RF1	Protein of unknown function DUF2625
APL_0928	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
APL_0929	ENOG4108Z4V	iron-sulfur cluster assembly
APL_0930	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
APL_0931	ENOG4105C3J	Cysteine desulfurase
APL_0932	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
APL_0933	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
APL_0934	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
APL_0935	ENOG4105BZU	Histidine kinase
APL_0936	ENOG4108TZV	Membrane
APL_0937	ENOG4108DG9	Smr protein MutS2
APL_0938	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
APL_0939	ENOG41090JN	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
APL_0940	ENOG4105HSA	Protein of unknown function (DUF452)
APL_0941	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
APL_0942	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
APL_0943	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
APL_0944	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
APL_0945	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
APL_0948	ENOG4108J1Q	
APL_0950	ENOG4105M03	Domain of unknown function (DUF955)
APL_0951	ENOG41067QW	Transcriptional regulator
APL_0957	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
APL_0958	ENOG4105DC1	bifunctional purine biosynthesis protein purh
APL_0959	ENOG4105CKT	filamentous hemagglutinin
APL_0962	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
APL_0963	ENOG4105D4P	Coproporphyrinogen iii oxidase
APL_0965	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
APL_0966	ENOG4105D0C	transport protein
APL_0967	ENOG4105D6U	Sodium Glutamate Symporter
APL_0968	ENOG4105XTV	UPF0231 protein
APL_0969	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
APL_0970	ENOG4105K9H	YciI-like protein
APL_0971	ENOG4105NAU	thioesterase Superfamily protein
APL_0972	ENOG4107835	probably involved in intracellular septation (By similarity)
APL_0974	ENOG4105PQ6	UPF0208 membrane protein
APL_0975	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
APL_0976	ENOG4105D3Y	Na H antiporter
APL_0977	ENOG4105CGK	Exodeoxyribonuclease III
APL_0978	ENOG4105EMY	transcriptional regulator
APL_0982	ENOG4105VFB	Binds the 23S rRNA (By similarity)
APL_0983	ENOG4105CV1	Transketolase (EC 2.2.1.1)
APL_0984	ENOG4105IYK	transposase
APL_0985	ENOG4105DQ6	Transposase
APL_0986	ENOG4105DQ6	Transposase
APL_0987	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
APL_0988	ENOG4105CH6	catalase
APL_0989	ENOG4105IYK	transposase
APL_0990	ENOG4105DQ6	Transposase
APL_0991	ENOG4107RN3	metallophosphoesterase
APL_0992	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APL_0993	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APL_0994	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
APL_0995	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
APL_0996	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
APL_0997	ENOG4105CNT	hydrolase family 2
APL_1000	ENOG4105D1F	ATP-binding protein
APL_1002	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
APL_1003	ENOG4105EIN	peptidylprolyl cis-trans isomerase
APL_1004	ENOG4105EEQ	Na H antiporter
APL_1005	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
APL_1006	ENOG4105CKW	Inner membrane protein yedI
APL_1007	ENOG410601J	HemY protein
APL_1008	ENOG4105ECF	c-methyltransferase
APL_1009	ENOG41076E6	Uroporphyrinogen-III Synthase
APL_1010	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
APL_1011	ENOG4108EKI	Dehydrogenase
APL_1012	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
APL_1013	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
APL_1014	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
APL_1015	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
APL_1016	ENOG4105D9N	nucleoside
APL_1017	ENOG4108VW9	Membrane
APL_1018	ENOG4108UHU	Aldolase
APL_1019	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
APL_1020	ENOG4105D2H	Uronic isomerase
APL_1022	ENOG4107YCY	Transcriptional regulator
APL_1024	ENOG4105E0X	reductase
APL_1025	ENOG4108RYC	glycosyltransferase
APL_1026	ENOG4108RJ9	Glycosyl transferase, family 2
APL_1028	ENOG41068D6	Glycosyltransferase
APL_1030	ENOG4108ZPC	Polysaccharide pyruvyl transferase
APL_1031	ENOG41080C8	DUF218 domain
APL_1032	ENOG4105C25	Primosomal protein n'
APL_1033	ENOG4105CQC	Prephenate dehydratase
APL_1034	ENOG4105DGW	oligopeptidase A
APL_1035	ENOG4105F1A	Pyruvate formate-lyase
APL_1036	ENOG4105C6N	Formate acetyltransferase
APL_1037	ENOG4105TMB	Formate nitrite transporter
APL_1038	ENOG4105W39	Membrane
APL_1039	ENOG4105D0M	Protease HtpX homolog
APL_1040	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
APL_1041	ENOG4105DWU	Membrane
APL_1042	ENOG4105E4F	Isochorismate synthase
APL_1043	ENOG4105CHM	Aminotransferase
APL_1044	ENOG4105DTR	rard protein
APL_1045	ENOG4105DTR	rard protein
APL_1046	ENOG4105N14	lysine exporter protein LysE YggA
APL_1048	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
APL_1051	ENOG4107QX9	Thiol disulfide interChange protein
APL_1052	ENOG4105DA4	cytochrome c-type biogenesis protein
APL_1053	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
APL_1054	ENOG4107T0K	Adenylate cyclase
APL_1055	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
APL_1056	ENOG4105IYK	transposase
APL_1057	ENOG4105IYK	transposase
APL_1058	ENOG4105DQ6	Transposase
APL_1059	ENOG4105DQ6	Transposase
APL_1060	ENOG4105WXI	Bacterial OB fold (BOF) protein
APL_1063	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
APL_1064	ENOG4105DHQ	Histidine kinase
APL_1065	ENOG4108UUE	Transcriptional regulator
APL_1066	ENOG4105VIE	preprotein translocase, subunit YajC
APL_1067	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
APL_1068	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
APL_1069	ENOG41090A1	ferritin
APL_1070	ENOG41090A1	ferritin
APL_1071	ENOG4105C7N	Xanthine uracil vitamin C permease
APL_1072	ENOG4108Z03	MAF-like protein
APL_1074	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
APL_1075	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
APL_1076	ENOG4105EPW	hflc protein
APL_1077	ENOG4107QJR	hflk protein
APL_1078	ENOG4105K63	Thioredoxin
APL_1080	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
APL_1082	ENOG4105D5Q	Arginine ornithine antiporter
APL_1083	ENOG4105D5Q	Arginine ornithine antiporter
APL_1085	ENOG4105CWC	Acetylornithine deacetylase
APL_1086	ENOG4105EIF	outer membrane protein W
APL_1087	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
APL_1088	ENOG4105D6J	arsenicaL-resistance protein
APL_1089	ENOG4105K89	arsenate reductase
APL_1091	ENOG4108IJ0	Aspartate ammonia-lyase
APL_1095	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
APL_1096	ENOG41069UX	Beta-N-acetyl-hexosaminidase
APL_1097	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
APL_1098	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
APL_1099	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
APL_1101	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
APL_1103	ENOG4108M8S	permease YjgP YjgQ family protein
APL_1104	ENOG4108K5H	permease YjgP YjgQ family protein
APL_1105	ENOG4105C0B	DNA polymerase III (alpha subunit)
APL_1106	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
APL_1107	ENOG4105E55	glycerol-3-phosphate acyltransferase
APL_1108	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
APL_1109	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
APL_1110	ENOG4105EE5	Membrane protein terC
APL_1111	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
APL_1112	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
APL_1113	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
APL_1115	ENOG4108VBH	Uncharacterized protein conserved in bacteria (DUF2251)
APL_1116	ENOG4105C9U	ATP-dependent DNA helicase RecQ
APL_1117	ENOG4105XQ6	frataxin-like protein
APL_1120	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APL_1121	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APL_1122	ENOG4105C34	Pseudouridine synthase
APL_1123	ENOG4108VTV	Inherit from NOG: Membrane
APL_1124	ENOG4105CTQ	phosphohexokinase
APL_1125	ENOG4105C9B	Cysteine desulfurase
APL_1126	ENOG4105KK6	nuclease
APL_1127	ENOG4105BZG	amino acid carrier protein
APL_1128	ENOG4105DSF	transport protein
APL_1130	ENOG4105CFP	Peptidase U32
APL_1131	ENOG4105PF3	O-Antigen polymerase
APL_1132	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
APL_1133	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
APL_1134	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
APL_1135	ENOG4105K8N	protein family UPF0079, ATPase
APL_1136	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
APL_1137	ENOG4107QP8	phosphohexose isomerase
APL_1138	ENOG4105W0Z	cytoplasmic protein
APL_1139	ENOG4105E2X	shikimate dehydrogenase
APL_1140	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APL_1141	ENOG41060QA	UPF0267 protein
APL_1142	ENOG4105Y3E	Modulates RecA activity (By similarity)
APL_1143	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
APL_1145	ENOG4105CRQ	synthase (Component I)
APL_1146	ENOG4105CGY	Dna recombination protein
APL_1146	ENOG4105CGY	Dna recombination protein
APL_1147	ENOG4105DDQ	anthranilate synthase
APL_1149	ENOG4105C9M	aspartyl-trna synthetase
APL_1150	ENOG4108TIT	dATP pyrophosphohydrolase
APL_1151	ENOG4105CDY	transcriptional regulatory protein
APL_1153	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
APL_1154	ENOG4107RAN	Peptidase, M16
APL_1155	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
APL_1158	ENOG4105DZ2	Transcriptional regulator
APL_1159	ENOG4106ZV1	Transferrin binding protein-like solute binding protein
APL_1160	ENOG4105FE9	pseudouridine synthase
APL_1161	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
APL_1162	ENOG4105EZR	dyp-type peroxidase family protein
APL_1163	ENOG4105CRQ	synthase (Component I)
APL_1164	ENOG4105DDQ	anthranilate synthase
APL_1165	ENOG4107QYG	anthranilate phosphoribosyltransferase
APL_1166	ENOG4105DMQ	Methyltransferase
APL_1167	ENOG4105RHG	
APL_1168	ENOG4105Z2P	Protein of unknown function (DUF465)
APL_1169	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
APL_1170	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
APL_1171	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
APL_1172	ENOG4105C12	Phosphoribosylglycinamide synthetase
APL_1174	ENOG4105N21	Membrane
APL_1176	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
APL_1177	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
APL_1178	ENOG4105CHH	sulfate transporter
APL_1179	ENOG4105CH7	arginosuccinase
APL_1180	ENOG4105D9R	oxidoreductase
APL_1181	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
APL_1182	ENOG4105E4P	ATPase (AAA
APL_1186	ENOG4105EXG	Transcriptional regulator
APL_1189	ENOG4107XVH	Transcriptional regulator
APL_1191	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
APL_1192	ENOG4105DEN	Luciferase family
APL_1196	ENOG4105DZR	Type I site-specific deoxyribonuclease
APL_1197	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
APL_1198	ENOG4108RCM	Nitroreductase
APL_1199	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
APL_1202	ENOG4105NI8	Cytosine-specific methyltransferase
APL_1204	ENOG4105C4W	S-formylglutathione hydrolase
APL_1209	ENOG4105C94	Transporter
APL_1212	ENOG4108NKP	c4-dicarboxylate transporter malic acid transport protein
APL_1213	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
APL_1215	ENOG4105BZ1	(ABC) transporter
APL_1216	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
APL_1217	ENOG4105DY2	Paraquat-inducible protein b
APL_1218	ENOG41090R7	Ferric uptake
APL_1219	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
APL_1220	ENOG4105NNH	LexA regulated protein
APL_1221	ENOG4108Z66	YbaK ebsC protein
APL_1222	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
APL_1223	ENOG4105C7N	Xanthine uracil vitamin C permease
APL_1224	ENOG41090EX	DsrE family
APL_1228	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
APL_1229	ENOG41062Z9	Membrane
APL_1230	ENOG4105EAC	phosphoserine phosphatase
APL_1231	ENOG4108VPT	UPF0234 protein
APL_1232	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
APL_1233	ENOG41061ZR	Transcriptional regulator
APL_1234	ENOG4107W52	maltose operon periplasmic protein
APL_1235	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
APL_1236	ENOG4108IJ9	(ABC) transporter
APL_1237	ENOG4107FKK	extracellular solute-binding protein family 1
APL_1238	ENOG4105D56	permease protein
APL_1239	ENOG4105EG2	ABC transporter, permease
APL_1240	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
APL_1242	ENOG4105EYA	deoxyribonuclease
APL_1243	ENOG4105DC8	reductase
APL_1245	ENOG4108TEB	UPF0114 protein
APL_1246	ENOG4108TVJ	Nitroreductase
APL_1250	ENOG4105D2N	Aldolase
APL_1251	ENOG4105BZA	Phosphoglycerate kinase
APL_1252	ENOG4105C8P	)-transporter
APL_1253	ENOG4105C8P	)-transporter
APL_1254	ENOG4105C8P	)-transporter
APL_1255	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APL_1256	ENOG4105BZU	Histidine kinase
APL_1257	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APL_1258	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
APL_1259	ENOG4105E2Z	phosphate ABC transporter (Permease
APL_1260	ENOG4105C8U	phosphate abc transporter
APL_1261	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
APL_1262	ENOG4108Z6Z	Transcriptional regulator
APL_1264	ENOG4105C59	p-type ATPase
APL_1265	ENOG4105C59	p-type ATPase
APL_1266	ENOG4105E1F	short-chain dehydrogenase reductase
APL_1267	ENOG41069NU	Nitroreductase
APL_1268	ENOG4105D07	Signal peptide peptidase, SppA
APL_1269	ENOG41083KI	ribonuclease, T2
APL_1270	ENOG4105GPY	SprT protein
APL_1271	ENOG4105CEP	NADH dehydrogenase
APL_1272	ENOG4105BZM	domain protein
APL_1273	ENOG41090FY	type IV pilus biogenesis stability protein PilW
APL_1274	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
APL_1275	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
APL_1276	ENOG4105VTW	prevent-host-death family
APL_1277	ENOG4105W49	UPF0434 protein
APL_1278	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
APL_1279	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
APL_1280	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
APL_1281	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
APL_1282	ENOG4107RZZ	dna polymerase iii epsilon subunit
APL_1283	ENOG4105C5H	ABC transporter
APL_1286	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
APL_1287	ENOG4105VFK	BolA family
APL_1289	ENOG4105E3I	toluene tolerance
APL_1290	ENOG4107PE3	Mammalian cell entry related domain protein
APL_1291	ENOG4105CY3	ABC transporter, permease
APL_1292	ENOG4105DHJ	ABC, transporter
APL_1293	ENOG4105C0H	protease
APL_1294	ENOG4105ECP	epimerase
APL_1295	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
APL_1296	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
APL_1298	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
APL_1300	ENOG4105EYM	Major Facilitator superfamily
APL_1301	ENOG4105CMR	udp-glucose 4-epimerase
APL_1302	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
APL_1305	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
APL_1309	ENOG4105D2S	major facilitator superfamily
APL_1310	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
APL_1311	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
APL_1312	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
APL_1313	ENOG4107RK2	ADP-ribose diphosphatase NudE
APL_1314	ENOG4105VEJ	Heat shock protein
APL_1315	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
APL_1316	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
APL_1317	ENOG4105DBV	ornithine carbamoyltransferase
APL_1318	ENOG4105C5B	carbamate kinase
APL_1319	ENOG4105C5Y	PTS System
APL_1320	ENOG4107T0D	ABC, transporter
APL_1321	ENOG4106SMU	thiamine transporter membrane protein
APL_1322	ENOG4105KZ7	phosphocarrier protein hpr
APL_1323	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
APL_1324	ENOG4105C5Y	PTS System
APL_1325	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APL_1326	ENOG4105C4R	Atp-dependent dna helicase
APL_1327	ENOG4107RSS	Hydrogenase accessory protein HypB
APL_1328	ENOG4105CQS	hydrogenase expression formation protein HypD
APL_1329	ENOG4105C45	hydrogenase expression formation protein (HypE)
APL_1330	ENOG4105C8H	hydrogenase maturation protein Hypf
APL_1331	ENOG4105E3S	small subunit
APL_1332	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
APL_1333	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
APL_1334	ENOG4105DPX	Hydrogenase, large subunit
APL_1335	ENOG4108USZ	hydrogenase
APL_1336	ENOG4108WGS	hydrogenase 2-specific chaperone
APL_1339	ENOG4108JA2	transcriptioN-repair coupling factor
APL_1340	ENOG4105CD8	aminopeptidase N
APL_1341	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
APL_1342	ENOG4107ZVW	dihydroneopterin aldolase
APL_1343	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
APL_1344	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
APL_1345	ENOG4105CAK	Cell division ATP-binding protein ftsE
APL_1346	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APL_1347	ENOG4106H78	methyltransferase
APL_1348	ENOG4105XW2	UPF0263 protein
APL_1349	ENOG4107UWN	reductase
APL_1351	ENOG4105DMR	ABC, transporter
APL_1352	ENOG4105GBT	ABC transporter
APL_1353	ENOG4106PMH	Extracellular solute-binding protein family 3
APL_1354	ENOG4105E5Z	arginine transporter ATP-binding subunit
APL_1355	ENOG4108V1U	phospholipid-binding protein
APL_1357	ENOG4105KDP	XRE family
APL_1359	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
APL_1360	ENOG4108BPE	-transporting atpase
APL_1361	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
APL_1362	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
APL_1363	ENOG41082RQ	UPF0102 protein
APL_1364	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
APL_1365	ENOG4105W4M	Transport-associated protein
APL_1366	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
APL_1367	ENOG4105DA4	cytochrome c-type biogenesis protein
APL_1368	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
APL_1369	ENOG4105X3C	heme exporter protein
APL_1370	ENOG41060IM	Heme exporter protein
APL_1371	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
APL_1372	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
APL_1373	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
APL_1376	ENOG4107QSA	Oxaloacetate decarboxylase
APL_1377	ENOG4105D9Q	decarboxylase (Beta subunit)
APL_1378	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
APL_1379	ENOG4105CA0	peroxidase
APL_1380	ENOG4105VZ9	UPF0235 protein
APL_1381	ENOG4108VIA	integral membrane protein
APL_1382	ENOG41090ED	Protein with unknown function (DUF469)
APL_1383	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
APL_1384	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
APL_1385	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
APL_1386	ENOG4105VGS	50s ribosomal protein l32
APL_1387	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
APL_1388	ENOG4106KVJ	cytochrome C assembly protein
APL_1389	ENOG4108JU6	CBS domain protein
APL_1390	ENOG4105C8J	)-transporter
APL_1391	ENOG4108EQA	pts system
APL_1392	ENOG4105ETZ	PTS System
APL_1393	ENOG4105F3R	pts system mannose fructose sorbose family iid
APL_1394	ENOG4108NK4	UPF0266 membrane protein
APL_1395	ENOG4105EIP	mannose-6-phosphate isomerase
APL_1398	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
APL_1399	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
APL_1400	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
APL_1401	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
APL_1402	ENOG4105D16	lipopolysaccharide heptosyltransferase i
APL_1403	ENOG4105XA0	heptosyltransferase ii
APL_1405	ENOG4108UBT	opacity-associated protein
APL_1406	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
APL_1407	ENOG4105DJ4	phosphatidylserine decarboxylase
APL_1408	ENOG4105D9M	gamma-glutamylcysteine synthetase
APL_1410	ENOG4105CIC	tryptophan-specific transport protein
APL_1411	ENOG4105KZW	UPF0381 protein
APL_1412	ENOG4107QM2	Aldo Keto reductase
APL_1413	ENOG4108IQE	Amp-dependent synthetase and ligase
APL_1414	ENOG4105DWT	malate dehydrogenase (quinone)
APL_1418	ENOG4108HWV	)-transporter
APL_1419	ENOG4105C2J	ABC transporter
APL_1420	ENOG4105EMA	Periplasmic binding protein LacI transcriptional regulator
APL_1421	ENOG4105W44	ompa motb domain protein
APL_1422	ENOG4105CQB	FAD linked oxidase domain protein
APL_1423	ENOG4105KA0	thioesterase Superfamily protein
APL_1425	ENOG4105CUW	cytochrome C-TYPE protein
APL_1426	ENOG4105IYZ	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity)
APL_1427	ENOG4105GXZ	Ferredoxin-type protein NapH
APL_1428	ENOG4108BGM	Quinol dehydrogenase periplasmic component
APL_1429	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
APL_1432	ENOG4105DYS	nad(p)h dehydrogenase (quinone)
APL_1433	ENOG4105DQ6	Transposase
APL_1434	ENOG4105IYK	transposase
APL_1436	ENOG4105C03	ribonuclease
APL_1438	ENOG4108WWS	isoprenylcysteine carboxyl methyltransferase
APL_1439	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
APL_1440	ENOG4105NXV	High-affinity zinc uptake system protein
APL_1442	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
APL_1443	ENOG4108JJA	ABC, transporter
APL_1444	ENOG4107G27	RTX N-terminal domain
APL_1445	ENOG41090Q8	at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP
APL_1446	ENOG4105C4Y	ABC transporter
APL_1447	ENOG4107RCV	ABC transporter, permease
APL_1448	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APL_1449	ENOG4105DFU	Cell wall formation (By similarity)
APL_1450	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APL_1452	ENOG4108JQ1	Dehydrogenase
APL_1453	ENOG4105E66	phosphoriboisomerase A
APL_1454	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
APL_1455	ENOG4105C7B	Threonine dehydratase
APL_1456	ENOG4108YZY	peptidylprolyl cis-trans isomerase
APL_1457	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
APL_1459	ENOG4108R96	Methyltransferase, YaeB family
APL_1460	ENOG4105DFS	Conserved Protein
APL_1461	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
APL_1462	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
APL_1463	ENOG4105MFV	ABC-2 type transporter
APL_1471	ENOG4105D3Q	Sugar transferase
APL_1472	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
APL_1473	ENOG4105VCC	30S ribosomal protein S21
APL_1474	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
APL_1475	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APL_1476	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
APL_1478	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
APL_1479	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APL_1480	ENOG4105EJ2	Transcriptional regulator
APL_1481	ENOG4105C5Q	Transcriptional regulator
APL_1482	ENOG4105EHV	domain protein
APL_1485	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
APL_1486	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
APL_1488	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
APL_1489	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
APL_1490	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
APL_1491	ENOG4105CAG	UPF0210 protein
APL_1492	ENOG4105VUC	UPF0237 protein
APL_1493	ENOG4105C2I	pirin domain protein
APL_1494	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
APL_1497	ENOG4105EM2	membrane
APL_1498	ENOG4108Z5K	methylglyoxal synthase
APL_1499	ENOG4105D98	threonine synthase
APL_1500	ENOG4105IYK	transposase
APL_1501	ENOG4105DQ6	Transposase
APL_1502	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
APL_1504	ENOG4107YB6	acetyltransferase, (GNAT) family
APL_1505	ENOG4105MYG	DNA polymerase iii, chi subunit
APL_1506	ENOG4108WZM	domain protein
APL_1507	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
APL_1508	ENOG4107YZP	Rhodanese domain protein
APL_1509	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
APL_1510	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
APL_1511	ENOG4105D7W	serine acetyltransferase
APL_1512	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
APL_1513	ENOG4105CS9	pantothenic acid kinase
APL_1514	ENOG4107QX9	Thiol disulfide interChange protein
APL_1515	ENOG4108M1T	Cytochrome c-type biogenesis protein
APL_1516	ENOG4108M1T	Cytochrome c-type biogenesis protein
APL_1517	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
APL_1518	ENOG4108YZA	Nitrogen regulatory protein pii
APL_1519	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
APL_1520	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
APL_1521	ENOG410863D	Flavinator of succinate dehydrogenase
APL_1523	ENOG4105D4P	Coproporphyrinogen iii oxidase
APL_1524	ENOG4108K3A	Glutathione S-transferase
APL_1525	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
APL_1526	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
APL_1527	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
APL_1528	ENOG4105E33	succinate dehydrogenase
APL_1529	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
APL_1530	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
APL_1531	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
APL_1532	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
APL_1535	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
APL_1536	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APL_1537	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
APL_1540	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
APL_1541	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
APL_1542	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APL_1543	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
APL_1544	ENOG4105DAD	Could be involved in ECA polysaccharide chain elongation (By similarity)
APL_1546	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
APL_1547	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
APL_1548	ENOG4105EGZ	biosynthesis protein
APL_1549	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
APL_1551	ENOG4108IJ1	Dehydrogenase
APL_1552	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
APL_1554	ENOG4105ESV	Glycosyl transferase, family 4
APL_1555	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
APL_1557	ENOG4105CJR	Integral membrane protein (MviN
APL_1558	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
APL_1559	ENOG4105C1A	potassium transporter peripheral membrane
APL_1560	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APL_1561	ENOG4105EM7	Selenocysteine-specific translation elongation factor
APL_1562	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
APL_1563	ENOG4105QTB	Flavodoxin
APL_1564	ENOG4105CMG	Carbohydrate kinase
APL_1567	ENOG4108MVK	Receptor
APL_1569	ENOG4105M8F	Biopolymer transport protein exbD tolR
APL_1572	ENOG4105DWU	Membrane
APL_1573	ENOG4105DG4	malate L-lactate dehydrogenase
APL_1574	ENOG4105MJ9	esterase
APL_1576	ENOG4105C2X	Arabinose 5-phosphate isomerase
APL_1577	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
APL_1578	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
APL_1586	ENOG4105DKW	ABC transporter
APL_1587	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
APL_1589	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
APL_1590	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
APL_1591	ENOG4108RR8	protoporphyrinogen oxidase
APL_1592	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
APL_1593	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
APL_1594	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
APL_1596	ENOG4105DZ1	carboxypeptidase
APL_1598	ENOG4105CNI	cell division protein FtsW
APL_1599	ENOG4105CJN	penicillin-binding protein
APL_1600	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
APL_1601	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
APL_1602	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
APL_1603	ENOG4105CDA	abc transporter atp-binding protein
APL_1604	ENOG4105E5Q	amino acid AbC transporter
APL_1605	ENOG4105CEM	UPF0597 protein
APL_1606	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
APL_1608	ENOG4105KZW	UPF0381 protein
APL_1611	ENOG4108XNJ	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
APL_1612	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
APL_1613	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
APL_1614	ENOG4105HFU	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
APL_1616	ENOG4105CQM	Urea amidohydrolase subunit alpha
APL_1617	ENOG4105KI2	Urea amidohydrolase subunit beta
APL_1618	ENOG4108YZ9	Urea amidohydrolase subunit gamma
APL_1620	ENOG4108JJB	ABC transporter
APL_1622	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
APL_1623	ENOG4108A51	
APL_1624	ENOG4105UZ0	ABC-type Co2 transport system, periplasmic component
APL_1627	ENOG4107QWE	)-transporter
APL_1628	ENOG4105E61	Mannitol repressor protein
APL_1629	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
APL_1630	ENOG4105CTS	PTS system mannitol-specific
APL_1631	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
APL_1632	ENOG410804X	Transcriptional regulator
APL_1635	ENOG4106YJS	accessory processing protein
APL_1636	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
APL_1637	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
APL_1639	ENOG4105VRX	Protein slyX homolog
APL_1640	ENOG4108V1T	peptidylprolyl cis-trans isomerase
APL_1641	ENOG4105WWK	YheO domain protein
APL_1642	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
APL_1643	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
APL_1645	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
APL_1646	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
APL_1647	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
APL_1648	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
APL_1649	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
APL_1650	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
APL_1651	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
APL_1652	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
APL_1654	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
APL_1655	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
APL_1656	ENOG410667J	hydrolase
APL_1657	ENOG4105EAB	amino acid AbC transporter
APL_1658	ENOG4105K5B	UPF0225 protein
APL_1660	ENOG4105F3R	pts system mannose fructose sorbose family iid
APL_1661	ENOG4105ETZ	PTS System
APL_1662	ENOG4108EQA	pts system
APL_1663	ENOG4105DQ6	Transposase
APL_1664	ENOG4105IYK	transposase
APL_1665	ENOG4105C6Z	Gluconate
APL_1666	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
APL_1667	ENOG4105DIQ	Transcriptional regulator
APL_1668	ENOG4105ETE	Transcriptional regulator (LacI family
APL_1669	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
APL_1671	ENOG4105CNN	ABC, transporter
APL_1672	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
APL_1673	ENOG4108RVA	ribokinase
APL_1674	ENOG4107QY8	reductase
APL_1675	ENOG4105QAX	Iron-sulfur
APL_1676	ENOG4107KGK	dmso reductase anchor subunit
APL_1677	ENOG4108NEM	leader-binding protein dmsD
APL_1678	ENOG4105N1P	Ferredoxin-type protein
APL_1683	ENOG4107EDW	L-fucose operon activator
APL_1684	ENOG4105EHF	Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity)
APL_1685	ENOG4105CMG	Carbohydrate kinase
APL_1686	ENOG4105NWF	RbsD or FucU transport
APL_1687	ENOG4107W7X	Aldolase
APL_1688	ENOG4105EDR	glucose galactose transporter
APL_1689	ENOG4105C0A	alcohol dehydrogenase
APL_1690	ENOG4105R3P	Inner membrane protein yagU
APL_1691	ENOG4105E5Q	amino acid AbC transporter
APL_1693	ENOG4105CDA	abc transporter atp-binding protein
APL_1694	ENOG4105CT1	(ABC) transporter
APL_1695	ENOG4105E12	capsule polysaccharide
APL_1696	ENOG41084CK	capsule polysaccharide
APL_1703	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
APL_1704	ENOG4107R0P	L-ribulose-5-phosphate 4-epimerase
APL_1705	ENOG4108V1T	peptidylprolyl cis-trans isomerase
APL_1710	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
APL_1712	ENOG4105C79	DNA protecting protein DprA
APL_1713	ENOG4105EPD	Oligopeptide transporter, Opt family
APL_1716	ENOG4105PM1	preprotein translocase subunit SecE
APL_1717	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
APL_1718	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
APL_1719	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
APL_1720	ENOG4108VZM	50s ribosomal protein L10
APL_1721	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
APL_1727	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APL_1728	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APL_1735	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
APL_1736	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
APL_1737	ENOG4105PW4	Sugar fermentation stimulation protein homolog
APL_1738	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
APL_1739	ENOG4105CEN	a g-specific adenine glycosylase
APL_1740	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
APL_1741	ENOG4105E4C	Lytic transglycosylase catalytic
APL_1742	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APL_1743	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
APL_1744	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
APL_1745	ENOG4105YES	addiction module antidote protein
APL_1746	ENOG4105VUH	addiction module killer protein
APL_1747	ENOG4105C0P	Mg chelatase subunit ChlI
APL_1748	ENOG4106IIQ	Outer membrane lipoprotein
APL_1749	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
APL_1750	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
APL_1752	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
APL_1753	ENOG4105EVU	fructokinase
APL_1754	ENOG4108MB0	N-acetylneuraminate lyase
APL_1755	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
APL_1756	ENOG4105CE4	GlcNAc 6-P deacetylase
APL_1757	ENOG4105C9Q	fumarate hydratase class II
APL_1760	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
APL_1761	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
APL_1762	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
APL_1763	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APL_1764	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
APL_1765	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
APL_1766	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
APL_1767	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
APL_1768	ENOG41083MP	50s ribosomal protein l29
APL_1769	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
APL_1770	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
APL_1771	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APL_1772	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
APL_1773	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
APL_1774	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
APL_1775	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
APL_1776	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
APL_1777	ENOG4105VPB	50S ribosomal protein L30
APL_1778	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
APL_1779	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
APL_1780	ENOG41067V7	50S ribosomal protein L36
APL_1781	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APL_1782	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
APL_1783	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
APL_1784	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APL_1786	ENOG4105K5M	30s ribosomal protein S16
APL_1787	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
APL_1788	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
APL_1789	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
APL_1790	ENOG4105EZE	Cupin 4 family protein
APL_1791	ENOG4105S10	periplasmic binding protein
APL_1792	ENOG4105EHG	Permease protein
APL_1798	ENOG4108J2R	molybdopterin oxidoreductase
APL_1800	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
APL_1801	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
APL_1803	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
APL_1808	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
APL_1809	ENOG4105RX8	Protein of unknown function (DUF1523)
APL_1810	ENOG4105F8V	Hydrolase, tatD family
APL_1814	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
APL_1815	ENOG4107ZJM	MltA-interacting protein MipA
APL_1816	ENOG4107QRG	dna polymerase iii
APL_1817	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
APL_1818	ENOG4105HHA	aminodeoxychorismate lyase
APL_1819	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
APL_1820	ENOG4105DJV	ribulose-phosphate 3-epimerase
APL_1821	ENOG4105NRA	50s ribosomal protein l31 type b
APL_1822	ENOG4105YK5	50S ribosomal protein L36
APL_1823	ENOG4105BZ4	penicillin-binding protein
APL_1824	ENOG4108IPT	Naphthoate synthase
APL_1825	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
APL_1826	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
APL_1827	ENOG4105CB5	ATP-dependent DNA helicase recG
APL_1830	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
APL_1831	ENOG4108WQI	RNA Polymerase
APL_1832	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
APL_1833	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
APL_1834	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APL_1835	ENOG4105CXY	transporter
APL_1837	ENOG4105CU9	asparagine synthetase A
APL_1838	ENOG4108VVK	transcriptional Regulator, AsnC
APL_1839	ENOG4108I5U	Uridine phosphorylase
APL_1840	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
APL_1841	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
APL_1842	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
APL_1843	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
APL_1845	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
APL_1846	ENOG4108I5D	sulfate abc transporter
APL_1847	ENOG4105ECW	sulfate abc transporter
APL_1848	ENOG4108IJ6	ABC transporter
APL_1849	ENOG4105DMF	Dehydrogenase
APL_1850	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
APL_1851	ENOG4105D4A	Cell wall formation (By similarity)
APL_1853	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
APL_1854	ENOG4105H2K	paraquat-inducible protein a
APL_1855	ENOG4108KS2	transglutaminase domain protein
APL_1857	ENOG410681U	heavy metal transport detoxification protein
APL_1859	ENOG4107QW4	alcohol dehydrogenase
APL_1860	ENOG4105EMY	transcriptional regulator
APL_1861	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
APL_1862	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
APL_1863	ENOG4108ST3	glycosyltransferase
APL_1864	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
APL_1865	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APL_1868	ENOG4108Z33	Thiol disulfide Interchange Protein
APL_1870	ENOG41063M6	Cell Division Protein
APL_1870	ENOG41063M6	Cell Division Protein
APL_1871	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
APL_1873	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
APL_1874	ENOG4105KUZ	arsenate reductase
APL_1876	ENOG4105EEI	dihydropteroate synthase
APL_1877	ENOG4105EI2	Pseudouridine synthase
APL_1881	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APL_1883	ENOG4107QXK	peptidase
APL_1884	ENOG4105DSY	exodeoxyribonuclease V, gamma
APL_1889	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
APL_1890	ENOG4105DAN	ATP-dependent protease
APL_1891	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
APL_1892	ENOG4105C31	Tryptophanyl-tRNA synthetase
APL_1895	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
APL_1896	ENOG4105HF0	Membrane
APL_1897	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
APL_1899	ENOG4105F0N	pyrophosphate phospho-hydrolase
APL_1900	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
APL_1901	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
APL_1902	ENOG4105TMB	Formate nitrite transporter
APL_1905	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
APL_1906	ENOG4105CFG	Acts as a chaperone (By similarity)
APL_1907	ENOG4105CMG	Carbohydrate kinase
APL_1908	ENOG4105C93	Xylose Isomerase
APL_1909	ENOG4105DFW	ABC transporter
APL_1910	ENOG4105C2J	ABC transporter
APL_1911	ENOG4108HWW	ABC transporter
APL_1912	ENOG4105T16	Transcriptional regulator (AraC family)
APL_1913	ENOG4105C9K	Endothelin-converting enzyme 1
APL_1915	ENOG4108IA2	Sodium pantothenate symporter
APL_1916	ENOG4105RG0	Membrane
APL_1917	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
APL_1918	ENOG410903C	(LipO)protein
APL_1919	ENOG4105DSB	aldose 1-epimerase
APL_1922	ENOG4107BJW	polysaccharide deacetylase
APL_1923	ENOG4105CND	Glycosyl transferase, family 2
APL_1925	ENOG4105CP7	Triose-phosphate isomerase
APL_1926	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
APL_1927	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
APL_1928	ENOG4108UM1	dedA family
APL_1930	ENOG4108K5P	(LipO)protein
APL_1931	ENOG4108R3E	Dna-3-methyladenine glycosylase i
APL_1934	ENOG4108P2H	Inner membrane protein YjiG
APL_1935	ENOG41074DU	domain protein
APL_1937	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
APL_1938	ENOG4105VG0	50S ribosomal protein l34
APL_1939	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
APL_1940	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
APL_1941	ENOG4105C5F	glutamine synthetase
APL_1942	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
APL_1943	ENOG41087AY	ADP-Ribose pyrophosphatase
APL_1944	ENOG4108VY7	phosphate-starvation-inducible protein PsiE
APL_1945	ENOG4105W8Z	4'-phosphopantetheinyl transferase
APL_1947	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
APL_1949	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
APL_1950	ENOG4107S2Z	UPF0761 membrane protein
APL_1951	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
APL_1960	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
APL_1961	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
APL_1962	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
APL_1963	ENOG4108URH	decarboxylase
APL_1964	ENOG4105TPC	MazG nucleotide pyrophosphohydrolase domain
APL_1965	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
APL_1966	ENOG4105YP7	UPF0270 protein
APL_1967	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
APL_1968	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
APL_1969	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
APL_1970	ENOG4105W5Q	DNA repair protein (RadC
APL_1971	ENOG4105KDC	50s ribosomal protein l28
APL_1972	ENOG4105W0E	50S ribosomal protein L33
APL_1974	ENOG4108JPW	Aminotransferase
APL_1975	ENOG4105DY8	decarboxylase
APL_1976	ENOG4105KSU	Redox protein
APL_1977	ENOG41066VF	YeeE YedE family protein
APL_1978	ENOG4108WFC	UPF0438 protein yifE
APL_1979	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
APL_1981	ENOG4107QUT	magnesium and cobalt transport protein CorA
APL_1982	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
APL_1984	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
APL_1985	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
APL_1986	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
APL_1987	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
APL_1988	ENOG4105D52	delta-aminolevulinic acid dehydratase
APL_1990	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
APL_1991	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
APL_1992	ENOG4105CHR	reductase
APL_1993	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
APL_1994	ENOG4105WPN	DNA integration recombination invertion protein
APL_1995	ENOG4105EAH	synthase
APL_1997	ENOG4108YYH	Nadph-dependent fmn reductase
APL_1998	ENOG4105MGM	doxx family
APL_1999	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
APL_2000	ENOG4105K46	50S ribosomal protein l27
APL_2001	ENOG4105QYV	Membrane
APL_2004	ENOG4105MJ2	Competence protein
APL_2005	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
APL_2007	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
APL_2008	ENOG4105C1J	atp-dependent rna helicase
APL_2009	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
APL_2010	ENOG4105DEF	Extracellular solute-binding protein, family 5
APL_2012	ENOG4106HK8	GPR1 FUN34 yaaH family protein
APL_2013	ENOG4105E0A	ABC, transporter
APL_2014	ENOG4105J76	Periplasmic binding protein
APL_2015	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
APL_2016	ENOG4105E0K	tonB-dependent siderophore receptor
APL_2018	ENOG4105C8V	SAICAR synthetase
APL_2019	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
APL_2020	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
APL_2021	ENOG4105CIH	Imidazole acetol-phosphate transaminase
APL_2023	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
APL_2024	ENOG4105DFS	Conserved Protein
APL_2025	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
APL_2026	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
APL_2028	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
APL_2029	ENOG4105EX9	Membrane
APL_2030	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
APL_2032	ENOG4105WBN	Transcriptional regulator (LacI family
APL_2034	ENOG4105D7K	pfkb domain protein
APL_2035	ENOG4105CEI	nitrite reductase
APL_2036	ENOG4105D60	lipoprotein releasing system transmembrane protein
APL_2037	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
APL_2038	ENOG4105D60	lipoprotein releasing system transmembrane protein
APL_2039	ENOG4105C5I	Dehydrogenase
APL_2041	ENOG41063JG	Transcriptional regulator
APL_2042	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
APL_2045	ENOG4107RM6	sulfurtransferase
APL_2046	ENOG4105CUC	YeeE YedE family protein