locus-tag	class	description
APL_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APL_0002	COG0592	DNA-directed DNA polymerase activity
APL_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APL_0005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APL_0007	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APL_0008	COG0616	signal peptide processing
APL_0009	COG2001	Belongs to the MraZ family
APL_0010	COG0275	rRNA processing
APL_0011	COG3116	cell division
APL_0012	COG0768	penicillin binding
APL_0013	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APL_0014	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APL_0015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APL_0016	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APL_0017	COG0772	Belongs to the SEDS family
APL_0018	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APL_0019	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APL_0020	COG1181	Belongs to the D-alanine--D-alanine ligase family
APL_0022	COG0849	cell division
APL_0023	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APL_0024	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APL_0025	COG0497	DNA recombination
APL_0026	COG4172	Belongs to the ABC transporter superfamily
APL_0027	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APL_0028	COG0601	transmembrane transport
APL_0030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APL_0033	COG0193	aminoacyl-tRNA hydrolase activity
APL_0034	COG0012	GTP binding
APL_0035	COG2020	methyltransferase activity
APL_0037	COG3133	Outer membrane lipoprotein
APL_0038	COG3102	Protein conserved in bacteria
APL_0039	COG0018	arginyl-trna synthetase
APL_0040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APL_0042	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APL_0043	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APL_0044	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APL_0045	COG0196	riboflavin kinase activity
APL_0046	COG3172	ATPase kinase involved in NAD metabolism
APL_0047	COG2129	metallophosphoesterase
APL_0048	COG0745	RESPONSE REGULATOR receiver
APL_0051	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APL_0052	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APL_0054	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APL_0055	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APL_0056	COG1561	YicC-like family, N-terminal region
APL_0057	COG0354	folic acid binding
APL_0058	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APL_0059	COG2197	response regulator
APL_0060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
APL_0060	COG0116	Belongs to the methyltransferase superfamily
APL_0061	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APL_0062	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APL_0063	COG0747	negative chemotaxis
APL_0064	COG0747	negative chemotaxis
APL_0065	COG0601	transmembrane transport
APL_0066	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APL_0067	COG0444	Belongs to the ABC transporter superfamily
APL_0068	COG4608	Belongs to the ABC transporter superfamily
APL_0071	COG0251	oxidation-reduction process
APL_0072	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APL_0073	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APL_0074	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APL_0075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APL_0076	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APL_0077	COG0848	biopolymer transport protein
APL_0078	COG0811	peptide transport
APL_0079	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APL_0080	COG3118	belongs to the thioredoxin family
APL_0081	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APL_0081	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APL_0081	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APL_0082	COG1461	Dihydroxyacetone kinase
APL_0083	COG2376	Dihydroxyacetone kinase
APL_0084	COG0492	ferredoxin-NADP+ reductase activity
APL_0085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APL_0086	COG3753	Protein conserved in bacteria
APL_0090	COG3030	protein affecting phage T7 exclusion by the F plasmid
APL_0091	COG0006	proline dipeptidase activity
APL_0092	COG0425	Belongs to the sulfur carrier protein TusA family
APL_0093	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
APL_0097	COG0129	dihydroxy-acid dehydratase activity
APL_0098	COG3978	acetolactate synthase activity
APL_0101	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APL_0102	COG0437	4 iron, 4 sulfur cluster binding
APL_0103	COG3301	Polysulphide reductase, NrfD
APL_0104	COG5295	Hep Hag repeat protein
APL_0104	COG5295	Hep Hag repeat protein
APL_0104	COG5295	Hep Hag repeat protein
APL_0104	COG5295	Hep Hag repeat protein
APL_0107	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APL_0108	COG1414	Transcriptional regulator
APL_0109	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APL_0110	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APL_0112	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APL_0113	COG3068	Protein conserved in bacteria
APL_0117	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APL_0118	COG1278	Cold shock
APL_0119	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
APL_0120	COG0793	Belongs to the peptidase S41A family
APL_0121	COG2989	Protein conserved in bacteria
APL_0122	COG3108	Peptidase M15
APL_0123	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APL_0126	COG0537	adenosine 5'-monophosphoramidase activity
APL_0127	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APL_0128	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APL_0129	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APL_0130	COG1162	GTPase activity
APL_0131	COG0583	DNA-binding transcription factor activity
APL_0132	COG1011	Hydrolase
APL_0133	COG0583	DNA-binding transcription factor activity
APL_0135	COG0252	asparaginase activity
APL_0136	COG0504	CTP synthase activity
APL_0137	COG5413	integral membrane protein
APL_0138	COG0066	3-isopropylmalate dehydratase activity
APL_0139	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APL_0140	COG3835	regulator
APL_0141	COG2610	gluconate transmembrane transporter activity
APL_0142	COG1929	Belongs to the glycerate kinase type-1 family
APL_0143	COG1254	Belongs to the acylphosphatase family
APL_0144	COG3593	DNA synthesis involved in DNA repair
APL_0145	COG1611	Belongs to the LOG family
APL_0146	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APL_0148	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APL_0149	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APL_0149	COG0316	Belongs to the HesB IscA family
APL_0150	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APL_0151	COG1805	sodium ion transport
APL_0152	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APL_0153	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APL_0154	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APL_0155	COG2871	sodium ion transport
APL_0156	COG1477	protein flavinylation
APL_0157	COG2991	Protein conserved in bacteria
APL_0158	COG0482	sulfurtransferase activity
APL_0159	COG2814	Major facilitator Superfamily
APL_0160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APL_0161	COG2974	May be involved in recombination
APL_0162	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APL_0165	COG4657	Part of a membrane complex involved in electron transport
APL_0166	COG2878	Part of a membrane complex involved in electron transport
APL_0167	COG4656	Part of a membrane complex involved in electron transport
APL_0169	COG4658	electron transport chain
APL_0172	COG1560	Kdo2-lipid A biosynthetic process
APL_0173	COG0402	S-adenosylhomocysteine deaminase activity
APL_0174	COG4143	(ABC) transporter
APL_0175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APL_0176	COG0617	tRNA 3'-terminal CCA addition
APL_0177	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APL_0179	COG2911	Protein conserved in bacteria
APL_0181	COG0346	lactoylglutathione lyase activity
APL_0182	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APL_0184	COG1605	Chorismate mutase
APL_0184	COG0287	Prephenate dehydrogenase
APL_0185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APL_0186	COG0859	PFAM glycosyl transferase family 9
APL_0187	COG0469	pyruvate kinase activity
APL_0188	COG2062	phosphohistidine phosphatase, SixA
APL_0189	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APL_0190	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APL_0191	COG0733	neurotransmitter:sodium symporter activity
APL_0192	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APL_0193	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APL_0194	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APL_0195	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APL_0196	COG4972	Pilus assembly protein
APL_0200	COG4796	Type ii and iii secretion system protein
APL_0201	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APL_0202	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APL_0203	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APL_0204	COG1280	lysine exporter protein (LysE YggA)
APL_0205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APL_0207	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APL_0208	COG2801	Transposase and inactivated derivatives
APL_0209	COG2801	Transposase and inactivated derivatives
APL_0210	COG2963	transposase activity
APL_0211	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APL_0212	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APL_0219	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APL_0223	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APL_0224	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APL_0225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APL_0228	COG1253	flavin adenine dinucleotide binding
APL_0229	COG0564	pseudouridine synthase activity
APL_0230	COG0588	phosphoglycerate mutase activity
APL_0231	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APL_0232	COG1678	Uncharacterized ACR, COG1678
APL_0233	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APL_0235	COG0271	Belongs to the BolA IbaG family
APL_0239	COG0653	protein targeting
APL_0241	COG0494	nUDIX hydrolase
APL_0242	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APL_0243	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APL_0244	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APL_0246	COG1629	transport
APL_0246	COG4771	TonB-dependent receptor
APL_0247	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APL_0248	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APL_0249	COG0083	homoserine kinase activity
APL_0250	COG0527	aspartate kinase activity
APL_0250	COG0460	homoserine dehydrogenase
APL_0251	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APL_0252	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APL_0253	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APL_0254	COG2195	Cleaves the N-terminal amino acid of tripeptides
APL_0255	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APL_0256	COG0194	GDP metabolic process
APL_0257	COG1538	Outer membrane efflux protein
APL_0258	COG2914	Belongs to the UPF0125 (RnfH) family
APL_0259	COG2867	negative regulation of translational initiation
APL_0260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APL_0261	COG4149	molybdate abc transporter
APL_0262	COG0725	ABC transporter, periplasmic molybdate-binding protein
APL_0263	COG0842	Transport permease protein
APL_0264	COG1131	(ABC) transporter
APL_0265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APL_0266	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APL_0268	COG0251	oxidation-reduction process
APL_0269	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APL_0270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APL_0271	COG1121	(ABC) transporter
APL_0273	COG2920	part of a sulfur-relay system
APL_0274	COG0670	Belongs to the BI1 family
APL_0275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APL_0277	COG0322	excinuclease ABC activity
APL_0278	COG0084	hydrolase, TatD family'
APL_0279	COG0210	DNA helicase
APL_0280	COG3842	ATPase activity
APL_0281	COG1176	ABC-type spermidine putrescine transport system, permease component I
APL_0282	COG1177	transmembrane transport
APL_0283	COG0632	four-way junction helicase activity
APL_0284	COG2255	four-way junction helicase activity
APL_0285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APL_0286	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APL_0295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APL_0297	COG1271	oxidase subunit
APL_0298	COG1294	oxidase, subunit
APL_0299	COG0824	Thioesterase
APL_0300	COG0811	peptide transport
APL_0301	COG0848	biopolymer transport protein
APL_0302	COG3064	Membrane
APL_0302	COG3064	Membrane
APL_0303	COG0823	Involved in the tonB-independent uptake of proteins
APL_0306	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APL_0307	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APL_0310	COG0303	'Molybdopterin
APL_0311	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APL_0312	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APL_0313	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APL_0314	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APL_0315	COG0564	pseudouridine synthase activity
APL_0316	COG3023	N-Acetylmuramoyl-L-alanine amidase
APL_0317	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APL_0318	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APL_0319	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APL_0320	COG0626	cystathionine gamma-synthase activity
APL_0321	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APL_0322	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APL_0324	COG1702	phosphate starvation-inducible protein PhoH
APL_0326	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APL_0327	COG0709	Synthesizes selenophosphate from selenide and ATP
APL_0329	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APL_0333	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APL_0334	COG1660	Displays ATPase and GTPase activities
APL_0335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APL_0336	COG1137	ATPase activity
APL_0337	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APL_0339	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APL_0340	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APL_0342	COG1704	LemA family
APL_0343	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APL_0343	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APL_0343	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APL_0344	COG1105	Belongs to the carbohydrate kinase PfkB family
APL_0345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APL_0345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APL_0346	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APL_0347	COG1523	belongs to the glycosyl hydrolase 13 family
APL_0348	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APL_0349	COG0297	glycogen (starch) synthase activity
APL_0350	COG0058	SHG alpha-glucan phosphorylase activity
APL_0351	COG0105	UTP biosynthetic process
APL_0352	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APL_0352	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APL_0354	COG1187	pseudouridine synthase activity
APL_0355	COG2814	Major facilitator Superfamily
APL_0357	COG3381	protein complex oligomerization
APL_0358	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
APL_0359	COG0791	NLP P60 protein
APL_0360	COG2932	Transcriptional regulator
APL_0361	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
APL_0362	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APL_0363	COG2990	Protein conserved in bacteria
APL_0365	COG1643	Atp-dependent helicase
APL_0366	COG2707	UPF0756 membrane protein
APL_0367	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APL_0368	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APL_0369	COG0534	Mate efflux family protein
APL_0370	COG1074	ATP-dependent DNA helicase activity
APL_0371	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APL_0372	COG4535	Mg2 and Co2 transporter CorC
APL_0374	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APL_0375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APL_0376	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APL_0377	COG2271	Major facilitator Superfamily
APL_0378	COG0584	glycerophosphoryl diester phosphodiesterase
APL_0379	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APL_0380	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
APL_0381	COG0247	lactate metabolic process
APL_0384	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APL_0384	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APL_0385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APL_0387	COG0517	IMP dehydrogenase activity
APL_0387	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APL_0389	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APL_0390	COG0385	Bile acid
APL_0391	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APL_0392	COG0561	phosphatase activity
APL_0394	COG1595	DNA-templated transcription, initiation
APL_0395	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APL_0397	COG0318	PFAM AMP-dependent synthetase and ligase
APL_0398	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APL_0399	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APL_0400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APL_0401	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APL_0402	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APL_0402	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APL_0403	COG1160	GTP binding
APL_0404	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APL_0405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APL_0406	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APL_0407	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APL_0408	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APL_0409	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APL_0412	COG0750	zinc metalloprotease
APL_0413	COG0575	Belongs to the CDS family
APL_0414	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APL_0415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APL_0417	COG0671	phosphoesterase, PA-phosphatase related
APL_0418	COG1534	Rna-binding protein
APL_0419	COG0463	Glycosyl transferase, family 2
APL_0420	COG1686	Belongs to the peptidase S11 family
APL_0421	COG0859	PFAM glycosyl transferase family 9
APL_0423	COG0328	RNA-DNA hybrid ribonuclease activity
APL_0424	COG1286	toxin biosynthetic process
APL_0425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APL_0427	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APL_0428	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APL_0429	COG3081	Nucleoid-associated protein
APL_0430	COG0251	oxidation-reduction process
APL_0434	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APL_0436	COG1792	Involved in formation and maintenance of cell shape
APL_0437	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APL_0438	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APL_0439	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APL_0440	COG0121	glutamine amidotransferase
APL_0441	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APL_0442	COG2949	membrane
APL_0444	COG1556	Lactate utilization protein
APL_0445	COG1139	Iron-sulfur cluster binding protein
APL_0446	COG0247	lactate metabolic process
APL_0447	COG1620	l-lactate permease
APL_0448	COG2916	Histone family protein nucleoid-structuring protein H-NS
APL_0449	COG1757	Na H antiporter
APL_0450	COG1879	ABC-type sugar transport system periplasmic component
APL_0451	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APL_0452	COG0045	succinate-CoA ligase (ADP-forming) activity
APL_0453	COG2990	Protein conserved in bacteria
APL_0454	COG0508	dehydrogenase complex catalyzes the overall conversion of
APL_0455	COG0567	Dehydrogenase, E1 component
APL_0456	COG1121	(ABC) transporter
APL_0457	COG0739	heme binding
APL_0458	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APL_0459	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APL_0461	COG0561	phosphatase activity
APL_0462	COG3850	Histidine kinase
APL_0464	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APL_0465	COG0393	Putative heavy-metal-binding
APL_0466	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APL_0467	COG2983	Belongs to the UPF0260 family
APL_0468	COG4221	oxidoreductase activity
APL_0469	COG0133	tryptophan synthase activity
APL_0470	COG0159	tryptophan synthase activity
APL_0473	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APL_0473	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APL_0474	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APL_0476	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APL_0477	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APL_0482	COG0640	Transcriptional regulator
APL_0484	COG0189	ligase activity
APL_0485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APL_0486	COG0280	phosphate acetyltransferase
APL_0486	COG0281	malic enzyme
APL_0487	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APL_0502	COG1403	HNH endonuclease
APL_0510	COG0740	serine-type endopeptidase activity
APL_0526	COG3683	transport system, periplasmic component
APL_0527	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APL_0528	COG1115	amino acid carrier protein
APL_0531	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APL_0532	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APL_0533	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APL_0534	COG2104	thiamine diphosphate biosynthetic process
APL_0535	COG2022	thiamine diphosphate biosynthetic process
APL_0536	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APL_0537	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APL_0538	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APL_0539	COG0351	phosphomethylpyrimidine kinase
APL_0541	COG0481	GTPase activity
APL_0542	COG0681	Belongs to the peptidase S26 family
APL_0543	COG0571	ribonuclease III activity
APL_0544	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APL_0545	COG1381	Involved in DNA repair and RecF pathway recombination
APL_0562	COG0433	COG0433 Predicted ATPase
APL_0563	COG1840	ABC-type Fe3 transport system, periplasmic component
APL_0565	COG4178	(ABC) transporter
APL_0566	COG0052	Belongs to the universal ribosomal protein uS2 family
APL_0567	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APL_0568	COG2194	sulfuric ester hydrolase activity
APL_0569	COG0528	UMP kinase activity
APL_0570	COG0233	cytoplasmic translational termination
APL_0571	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APL_0572	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
APL_0573	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
APL_0574	COG0590	tRNA wobble adenosine to inosine editing
APL_0575	COG0513	Belongs to the DEAD box helicase family
APL_0576	COG4785	May be involved in cell division
APL_0577	COG1185	polyribonucleotide nucleotidyltransferase activity
APL_0578	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APL_0579	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
APL_0580	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APL_0581	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APL_0583	COG3083	sulfuric ester hydrolase activity
APL_0584	COG3082	Protein of unknown function (DUF1414)
APL_0585	COG1309	transcriptional regulator
APL_0586	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APL_0587	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APL_0588	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APL_0590	COG3955	Domain of unknown function (DUF1919)
APL_0591	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APL_0592	COG0519	Catalyzes the synthesis of GMP from XMP
APL_0592	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APL_0593	COG0517	IMP dehydrogenase activity
APL_0593	COG0516	GMP reductase activity
APL_0594	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APL_0595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APL_0596	COG0814	amino acid
APL_0597	COG0814	amino acid
APL_0599	COG3105	Protein conserved in bacteria
APL_0600	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APL_0601	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APL_0602	COG3022	response to hydroperoxide
APL_0605	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
APL_0606	COG1823	symporter activity
APL_0607	COG0778	Nitroreductase
APL_0608	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APL_0609	COG0072	phenylalanine-tRNA ligase activity
APL_0610	COG0776	regulation of translation
APL_0611	COG0791	NLP P60 protein
APL_0612	COG2801	Transposase and inactivated derivatives
APL_0613	COG2963	transposase activity
APL_0614	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APL_0615	COG1846	Transcriptional regulator
APL_0615	COG1940	carbohydrate kinase activity
APL_0616	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APL_0617	COG1522	sequence-specific DNA binding
APL_0618	COG1674	ftsk spoiiie
APL_0619	COG2321	neutral zinc metallopeptidase
APL_0620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APL_0621	COG1214	PFAM Peptidase M22, glycoprotease
APL_0622	COG1435	thymidine kinase activity
APL_0623	COG3074	FtsZ-dependent cytokinesis
APL_0624	COG1494	fructose-1,6-bisphosphatase
APL_0625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APL_0626	COG0577	efflux transmembrane transporter activity
APL_0626	COG1136	(ABC) transporter
APL_0627	COG2205	protein histidine kinase activity
APL_0629	COG0745	RESPONSE REGULATOR receiver
APL_0630	COG3956	TIGRFAM MazG family protein
APL_0631	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APL_0632	COG0285	dihydrofolate synthase activity
APL_0633	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APL_0634	COG0732	type I restriction modification DNA specificity domain
APL_0636	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APL_0637	COG0779	Required for maturation of 30S ribosomal subunits
APL_0638	COG0195	Participates in both transcription termination and antitermination
APL_0639	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APL_0640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APL_0641	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APL_0642	COG2951	lytic endotransglycosylase activity
APL_0644	COG0280	phosphate acetyltransferase
APL_0644	COG0857	belongs to the CobB CobQ family
APL_0645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APL_0646	COG0737	Belongs to the 5'-nucleotidase family
APL_0651	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APL_0653	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APL_0654	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APL_0655	COG0589	response to stress
APL_0657	COG2969	positive regulation of protein catabolic process
APL_0658	COG0625	glutathione transferase activity
APL_0659	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APL_0661	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APL_0662	COG1448	Aminotransferase
APL_0663	COG0006	proline dipeptidase activity
APL_0667	COG0556	nucleotide-excision repair
APL_0668	COG2822	iron ion transport
APL_0669	COG2837	iron assimilation
APL_0671	COG0613	PHP domain protein
APL_0673	COG2925	Exonuclease
APL_0674	COG0038	chloride channel
APL_0675	COG0017	Asparaginyl-tRNA synthetase
APL_0676	COG1509	lysine 2,3-aminomutase activity
APL_0678	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APL_0679	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APL_0680	COG2814	Major facilitator Superfamily
APL_0681	COG0741	lytic transglycosylase activity
APL_0682	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APL_0683	COG0626	cystathionine gamma-synthase activity
APL_0684	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APL_0685	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
APL_0686	COG2363	Small membrane protein
APL_0687	COG0277	FAD linked oxidase domain protein
APL_0688	COG0243	molybdopterin cofactor binding
APL_0689	COG3005	denitrification pathway
APL_0690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APL_0691	COG0315	cyclic pyranopterin monophosphate synthase activity
APL_0692	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APL_0693	COG0314	molybdopterin synthase activity
APL_0694	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APL_0695	COG1444	tRNA N-acetyltransferase activity
APL_0697	COG0583	DNA-binding transcription factor activity
APL_0698	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APL_0698	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APL_0699	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APL_0702	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APL_0703	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APL_0706	COG1737	Transcriptional regulator
APL_0707	COG2731	YhcH YjgK YiaL family protein
APL_0708	COG0248	Ppx GppA phosphatase
APL_0710	COG0527	aspartate kinase activity
APL_0711	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APL_0712	COG3100	YcgL domain-containing protein
APL_0713	COG0305	Participates in initiation and elongation during chromosome replication
APL_0714	COG4607	ABC-type enterochelin transport system periplasmic component
APL_0715	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APL_0716	COG4605	iron ion homeostasis
APL_0717	COG4604	ABC transporter, ATP-binding protein
APL_0718	COG1392	Phosphate transport regulator
APL_0719	COG0306	phosphate transporter
APL_0720	COG4991	sh3 domain protein
APL_0722	COG3945	hemerythrin HHE cation binding domain
APL_0723	COG0343	queuine tRNA-ribosyltransferase activity
APL_0725	COG1278	Cold shock
APL_0726	COG0288	reversible hydration of carbon dioxide
APL_0727	COG0028	Belongs to the TPP enzyme family
APL_0728	COG0440	acetolactate synthase activity
APL_0729	COG0312	modulator of DNA gyrase
APL_0730	COG3028	Belongs to the UPF0307 family
APL_0731	COG3094	Invasion gene expression up-regulator, SirB
APL_0733	COG1811	Na channel or pump
APL_0734	COG3787	Belongs to the UPF0306 family
APL_0735	COG0023	Translation Initiation Factor
APL_0736	COG0284	orotidine-5'-phosphate decarboxylase activity
APL_0737	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APL_0738	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APL_0739	COG0776	regulation of translation
APL_0740	COG0539	negative regulation of cytoplasmic translation
APL_0742	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APL_0743	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APL_0747	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
APL_0748	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APL_0749	COG3264	Mechanosensitive ion channel
APL_0749	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APL_0750	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APL_0750	COG3264	Mechanosensitive ion channel
APL_0751	COG0318	PFAM AMP-dependent synthetase and ligase
APL_0752	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APL_0753	COG0596	Alpha beta hydrolase
APL_0754	COG2226	methyltransferase
APL_0755	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APL_0757	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
APL_0758	COG1380	Effector of murein hydrolase LrgA
APL_0759	COG1346	cytolysis
APL_0760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APL_0761	COG3036	rescue of stalled ribosome
APL_0762	COG2226	methyltransferase
APL_0765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APL_0766	COG2333	competence protein COMEC
APL_0766	COG0658	competence protein
APL_0767	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APL_0768	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APL_0769	COG0737	Belongs to the 5'-nucleotidase family
APL_0771	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APL_0772	COG0508	dehydrogenase complex catalyzes the overall conversion of
APL_0773	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APL_0774	COG0167	dihydroorotate dehydrogenase activity
APL_0775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APL_0776	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APL_0777	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
APL_0778	COG1132	(ABC) transporter
APL_0779	COG1346	cytolysis
APL_0781	COG1199	ATP-dependent helicase activity
APL_0782	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APL_0783	COG0629	single-stranded DNA binding
APL_0789	COG2070	2-Nitropropane dioxygenase
APL_0792	COG2315	Protein conserved in bacteria
APL_0793	COG4172	Belongs to the ABC transporter superfamily
APL_0794	COG4171	peptide transport system, permease
APL_0795	COG4168	peptide transport system, permease
APL_0796	COG4166	transmembrane transport
APL_0797	COG3283	Transcriptional regulator of aromatic amino acids metabolism
APL_0798	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APL_0800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APL_0801	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APL_0802	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APL_0803	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APL_0804	COG1368	sulfuric ester hydrolase activity
APL_0805	COG3217	Mosc domain protein beta barrel domain protein
APL_0805	COG0633	Ferredoxin
APL_0806	COG1722	exodeoxyribonuclease VII activity
APL_0807	COG0142	geranyltranstransferase activity
APL_0809	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APL_0810	COG1530	ribonuclease E activity
APL_0811	COG1944	ATP diphosphatase activity
APL_0814	COG0500	methyltransferase
APL_0816	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APL_0818	COG2351	hydroxyisourate hydrolase activity
APL_0819	COG1609	Transcriptional regulator
APL_0820	COG0586	Pfam SNARE associated Golgi protein
APL_0821	COG0187	DNA topoisomerase II activity
APL_0822	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APL_0823	COG1349	DNA-binding transcription factor activity
APL_0824	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APL_0825	COG2915	High frequency lysogenization protein hflD homolog
APL_0826	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APL_0827	COG4988	ABC transporter
APL_0828	COG2911	Protein conserved in bacteria
APL_0829	COG0729	surface antigen
APL_0830	COG2861	carbohydrate metabolic process
APL_0831	COG4942	peptidase
APL_0832	COG0588	phosphoglycerate mutase activity
APL_0834	COG0572	uridine kinase
APL_0835	COG0717	Belongs to the dCTP deaminase family
APL_0836	COG1309	transcriptional regulator
APL_0837	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APL_0838	COG0842	Transport permease protein
APL_0838	COG1129	ABC transporter
APL_0839	COG0842	Transport permease protein
APL_0841	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APL_0842	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APL_0843	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APL_0844	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APL_0844	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APL_0845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APL_0846	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APL_0847	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APL_0848	COG4166	transmembrane transport
APL_0850	COG0444	Belongs to the ABC transporter superfamily
APL_0851	COG4608	Belongs to the ABC transporter superfamily
APL_0853	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APL_0855	COG0747	negative chemotaxis
APL_0856	COG0814	amino acid
APL_0857	COG1760	l-serine dehydratase
APL_0858	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APL_0858	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APL_0859	COG0134	indole-3-glycerol-phosphate synthase activity
APL_0859	COG0135	phosphoribosylanthranilate isomerase activity
APL_0860	COG3177	Filamentation induced by cAMP protein fic
APL_0861	COG3098	single-species biofilm formation
APL_0862	COG0564	pseudouridine synthase activity
APL_0863	COG3140	Belongs to the UPF0181 family
APL_0865	COG3025	triphosphatase activity
APL_0866	COG3106	COG3106 Predicted ATPase
APL_0867	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APL_0868	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APL_0869	COG1473	amidohydrolase
APL_0870	COG3069	C4-dicarboxylate transmembrane transporter activity
APL_0871	COG3340	Belongs to the peptidase S51 family
APL_0872	COG0495	leucyl-tRNA aminoacylation
APL_0873	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
APL_0874	COG1466	dna polymerase III delta subunit
APL_0875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APL_0876	COG0237	dephospho-CoA kinase activity
APL_0878	COG1459	type II secretion system
APL_0879	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APL_0880	COG4969	Belongs to the N-Me-Phe pilin family
APL_0881	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APL_0883	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APL_0884	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APL_0885	COG0730	response to heat
APL_0886	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APL_0888	COG1024	Enoyl-CoA hydratase
APL_0888	COG1250	3-hydroxyacyl-CoA dehydrogenase
APL_0891	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APL_0892	COG0243	molybdopterin cofactor binding
APL_0892	COG3383	formate dehydrogenase (NAD+) activity
APL_0893	COG3383	formate dehydrogenase (NAD+) activity
APL_0893	COG0243	molybdopterin cofactor binding
APL_0894	COG0437	4 iron, 4 sulfur cluster binding
APL_0895	COG2864	formate dehydrogenase
APL_0896	COG3058	Necessary for formate dehydrogenase activity
APL_0897	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APL_0899	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APL_0900	COG1560	Kdo2-lipid A biosynthetic process
APL_0901	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APL_0902	COG0101	tRNA pseudouridine synthase activity
APL_0903	COG0302	gtp cyclohydrolase
APL_0904	COG3642	lipopolysaccharide core region biosynthetic process
APL_0906	COG0110	maltose O-acetyltransferase activity
APL_0908	COG0583	DNA-binding transcription factor activity
APL_0912	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APL_0913	COG0215	cysteine-tRNA ligase activity
APL_0914	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APL_0915	COG0617	tRNA 3'-terminal CCA addition
APL_0916	COG2963	transposase activity
APL_0917	COG2801	Transposase and inactivated derivatives
APL_0918	COG2801	Transposase and inactivated derivatives
APL_0923	COG2975	iron-sulfur cluster assembly
APL_0924	COG0633	Ferredoxin
APL_0925	COG0443	Heat shock 70 kDa protein
APL_0928	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APL_0930	COG0822	iron-sulfur transferase activity
APL_0931	COG1104	cysteine desulfurase activity
APL_0932	COG1959	2 iron, 2 sulfur cluster binding
APL_0934	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APL_0935	COG5002	protein histidine kinase activity
APL_0935	COG0784	Response regulator, receiver
APL_0935	COG2198	Histidine kinase
APL_0936	COG0697	spore germination
APL_0937	COG2840	Smr protein MutS2
APL_0938	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APL_0939	COG2226	methyltransferase
APL_0940	COG2830	Protein of unknown function (DUF452)
APL_0941	COG0156	8-amino-7-oxononanoate synthase activity
APL_0942	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APL_0944	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APL_0945	COG2027	D-alanyl-D-alanine carboxypeptidase
APL_0948	COG2801	Transposase and inactivated derivatives
APL_0950	COG2856	Zn peptidase
APL_0951	COG3620	sequence-specific DNA binding
APL_0957	COG1444	tRNA N-acetyltransferase activity
APL_0958	COG0138	bifunctional purine biosynthesis protein purh
APL_0959	COG3210	domain, Protein
APL_0962	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APL_0963	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APL_0965	COG3078	GTPase activator activity
APL_0966	COG0569	domain protein
APL_0966	COG2985	domain, Protein
APL_0967	COG0786	glutamate:sodium symporter activity
APL_0968	COG3112	Uncharacterised protein family (UPF0231)
APL_0970	COG2350	Protein conserved in bacteria
APL_0971	COG1607	acyl-coa hydrolase
APL_0972	COG2917	probably involved in intracellular septation
APL_0974	COG3092	negative regulation of chromosome organization
APL_0975	COG0037	tRNA processing
APL_0976	COG2056	Na+-H+ antiporter family
APL_0977	COG0708	Exodeoxyribonuclease III
APL_0978	COG0583	DNA-binding transcription factor activity
APL_0982	COG0254	rRNA binding
APL_0984	COG2963	transposase activity
APL_0985	COG2801	Transposase and inactivated derivatives
APL_0986	COG2801	Transposase and inactivated derivatives
APL_0987	COG0326	Molecular chaperone. Has ATPase activity
APL_0988	COG0753	catalase activity
APL_0989	COG2963	transposase activity
APL_0990	COG2801	Transposase and inactivated derivatives
APL_0991	COG1408	metallophosphoesterase
APL_0992	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APL_0993	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APL_0994	COG1085	galactose-1-phosphate uridylyltransferase
APL_0995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APL_0996	COG2017	converts alpha-aldose to the beta-anomer
APL_1000	COG0489	protein tyrosine kinase activity
APL_1002	COG2095	MarC family integral membrane protein
APL_1003	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APL_1005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APL_1006	COG2354	Protein conserved in bacteria
APL_1007	COG3071	HemY protein
APL_1008	COG2959	enzyme of heme biosynthesis
APL_1010	COG0181	hydroxymethylbilane synthase activity
APL_1011	COG1012	belongs to the aldehyde dehydrogenase family
APL_1011	COG1454	alcohol dehydrogenase
APL_1012	COG0459	protein refolding
APL_1013	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APL_1014	COG0813	purine-nucleoside phosphorylase activity
APL_1015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APL_1016	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APL_1017	COG2364	Membrane
APL_1018	COG0800	Aldolase
APL_1019	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APL_1020	COG1904	glucuronate isomerase
APL_1022	COG2186	Transcriptional regulator
APL_1024	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APL_1024	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APL_1025	COG1216	Glycosyl transferase, family 2
APL_1026	COG1216	Glycosyl transferase, family 2
APL_1028	COG3306	glycosyltransferase involved in LPS biosynthesis
APL_1030	COG5039	Polysaccharide pyruvyl transferase
APL_1031	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APL_1032	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APL_1033	COG0077	Prephenate dehydratase
APL_1033	COG1605	Chorismate mutase
APL_1034	COG0339	signal peptide processing
APL_1035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APL_1036	COG1882	Formate acetyltransferase
APL_1037	COG2116	formate transmembrane transporter activity
APL_1038	COG1238	metal cluster binding
APL_1039	COG0501	Belongs to the peptidase M48B family
APL_1040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APL_1041	COG2431	L-lysine efflux transmembrane transporter activity
APL_1042	COG1169	isochorismate synthase
APL_1043	COG0436	Aminotransferase
APL_1044	COG2962	Rard protein
APL_1045	COG2962	Rard protein
APL_1046	COG1280	lysine exporter protein (LysE YggA)
APL_1047	COG4771	TonB-dependent receptor
APL_1047	COG1629	transport
APL_1048	COG0748	coenzyme F420 binding
APL_1051	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APL_1052	COG1138	Cytochrome C-type biogenesis protein
APL_1053	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APL_1053	COG0475	glutathione-regulated potassium exporter activity
APL_1055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APL_1056	COG2963	transposase activity
APL_1057	COG2963	transposase activity
APL_1058	COG2801	Transposase and inactivated derivatives
APL_1059	COG2801	Transposase and inactivated derivatives
APL_1060	COG3111	PFAM Bacterial OB fold (BOF) protein
APL_1063	COG0745	RESPONSE REGULATOR receiver
APL_1064	COG0642	Histidine kinase
APL_1065	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APL_1066	COG1862	Preprotein translocase
APL_1067	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APL_1068	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APL_1069	COG1528	Iron-storage protein
APL_1070	COG1528	Iron-storage protein
APL_1071	COG2252	PERMEase
APL_1072	COG0424	maF-like protein
APL_1074	COG0301	tRNA thio-modification
APL_1074	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APL_1075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APL_1076	COG0330	HflC and HflK could
APL_1077	COG0330	HflC and HflK could
APL_1078	COG3118	belongs to the thioredoxin family
APL_1080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APL_1082	COG0531	amino acid
APL_1083	COG0531	amino acid
APL_1086	COG3047	cAMP biosynthetic process
APL_1087	COG0542	response to heat
APL_1088	COG0798	PFAM Bile acid sodium symporter
APL_1089	COG1393	Belongs to the ArsC family
APL_1091	COG1027	Aspartate ammonia-lyase
APL_1095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APL_1096	COG3064	Membrane
APL_1096	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APL_1096	COG3583	domain protein
APL_1097	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APL_1098	COG0720	synthase
APL_1099	COG0602	queuosine metabolic process
APL_1101	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APL_1103	COG0795	lipopolysaccharide-transporting ATPase activity
APL_1104	COG0795	lipopolysaccharide-transporting ATPase activity
APL_1106	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APL_1107	COG2937	Belongs to the GPAT DAPAT family
APL_1108	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APL_1109	COG3066	DNA modification
APL_1110	COG0861	Integral membrane protein TerC family
APL_1111	COG1472	Belongs to the glycosyl hydrolase 3 family
APL_1112	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APL_1113	COG0148	phosphopyruvate hydratase activity
APL_1114	COG1051	belongs to the nudix hydrolase family
APL_1115	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
APL_1117	COG1965	Belongs to the frataxin family
APL_1120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APL_1121	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APL_1122	COG0564	pseudouridine synthase activity
APL_1124	COG0205	6-phosphofructokinase activity
APL_1125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APL_1126	COG1525	nuclease
APL_1127	COG1115	amino acid carrier protein
APL_1128	COG0628	permease
APL_1131	COG3307	-O-antigen
APL_1132	COG1519	Transferase
APL_1133	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APL_1134	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APL_1135	COG0802	atpase or kinase
APL_1136	COG0860	N-Acetylmuramoyl-L-alanine amidase
APL_1136	COG1388	LysM domain
APL_1137	COG0166	Belongs to the GPI family
APL_1138	COG2960	long-chain fatty acid transporting porin activity
APL_1139	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APL_1140	COG0009	L-threonylcarbamoyladenylate synthase
APL_1142	COG2137	regulation of response to DNA damage stimulus
APL_1143	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APL_1144	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APL_1146	COG1322	Protein conserved in bacteria
APL_1146	COG1322	Protein conserved in bacteria
APL_1147	COG0512	Glutamine amidotransferase of anthranilate synthase
APL_1149	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APL_1150	COG0494	nUDIX hydrolase
APL_1151	COG0217	transcriptional regulatory protein
APL_1153	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APL_1154	COG0612	Peptidase, M16
APL_1155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APL_1158	COG0583	DNA-binding transcription factor activity
APL_1159	COG3266	domain, Protein
APL_1160	COG1187	pseudouridine synthase activity
APL_1161	COG0009	L-threonylcarbamoyladenylate synthase
APL_1162	COG2837	iron assimilation
APL_1163	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APL_1164	COG0512	Glutamine amidotransferase of anthranilate synthase
APL_1165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APL_1166	COG2226	methyltransferase
APL_1167	COG2268	Band 7 protein
APL_1168	COG2841	Protein conserved in bacteria
APL_1169	COG0359	binds to the 23S rRNA
APL_1170	COG2965	DNA replication, synthesis of RNA primer
APL_1171	COG0360	Binds together with S18 to 16S ribosomal RNA
APL_1173	COG3201	nicotinamide mononucleotide transporter
APL_1174	COG2976	Protein conserved in bacteria
APL_1176	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APL_1177	COG1426	Protein conserved in bacteria
APL_1178	COG0659	secondary active sulfate transmembrane transporter activity
APL_1179	COG0165	Argininosuccinate lyase
APL_1180	COG0673	inositol 2-dehydrogenase activity
APL_1181	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APL_1181	COG0475	glutathione-regulated potassium exporter activity
APL_1182	COG1373	ATPase (AAA superfamily
APL_1191	COG1902	pentaerythritol trinitrate reductase activity
APL_1192	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APL_1196	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APL_1197	COG2084	Dehydrogenase
APL_1198	COG0778	Nitroreductase
APL_1199	COG2095	MarC family integral membrane protein
APL_1205	COG0625	glutathione transferase activity
APL_1208	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APL_1209	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APL_1212	COG1275	C4-dicarboxylate transporter malic acid transport protein
APL_1213	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APL_1215	COG1132	(ABC) transporter
APL_1216	COG1854	S-ribosylhomocysteine lyase activity
APL_1217	COG3008	intermembrane lipid transfer
APL_1218	COG0735	belongs to the Fur family
APL_1219	COG0716	FMN binding
APL_1221	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APL_1222	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APL_1223	COG2252	PERMEase
APL_1224	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APL_1228	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APL_1230	COG0560	Phosphoserine phosphatase
APL_1231	COG1666	GTP binding
APL_1232	COG0058	SHG alpha-glucan phosphorylase activity
APL_1233	COG2909	trisaccharide binding
APL_1235	COG4580	involved in the transport of maltose and maltodextrins
APL_1236	COG3842	ATPase activity
APL_1239	COG3833	ABC-type maltose transport systems, permease component
APL_1240	COG1640	4-alpha-glucanotransferase
APL_1241	COG1966	Carbon starvation protein
APL_1242	COG0084	hydrolase, TatD family'
APL_1243	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APL_1246	COG0778	Nitroreductase
APL_1249	COG4172	Belongs to the ABC transporter superfamily
APL_1250	COG0191	fructose-bisphosphate aldolase activity
APL_1251	COG0126	phosphoglycerate kinase activity
APL_1252	COG0471	metal ion transport
APL_1253	COG0471	metal ion transport
APL_1254	COG0471	metal ion transport
APL_1255	COG0187	DNA topoisomerase II activity
APL_1256	COG5002	protein histidine kinase activity
APL_1257	COG0745	RESPONSE REGULATOR receiver
APL_1262	COG0789	Transcriptional regulator
APL_1264	COG2217	Heavy metal translocating P-type atpase
APL_1266	COG0300	oxidoreductase activity
APL_1267	COG0778	Nitroreductase
APL_1268	COG0616	signal peptide processing
APL_1269	COG3719	Belongs to the RNase T2 family
APL_1271	COG1252	NADH dehydrogenase
APL_1272	COG2183	response to ionizing radiation
APL_1273	COG3063	Type IV pilus biogenesis stability protein PilW
APL_1274	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APL_1275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APL_1276	COG2161	toxin-antitoxin pair type II binding
APL_1277	COG2835	tetraacyldisaccharide 4'-kinase activity
APL_1278	COG1663	tetraacyldisaccharide 4'-kinase activity
APL_1279	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APL_1280	COG0740	serine-type endopeptidase activity
APL_1281	COG2166	iron-sulfur cluster assembly
APL_1283	COG0488	(ABC) transporter
APL_1284	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APL_1286	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APL_1287	COG5007	Belongs to the BolA IbaG family
APL_1289	COG2854	intermembrane phospholipid transfer
APL_1290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APL_1291	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APL_1292	COG1127	ABC transporter
APL_1293	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APL_1294	COG1090	epimerase
APL_1295	COG1438	arginine binding
APL_1296	COG0039	L-malate dehydrogenase activity
APL_1298	COG0563	adenylate kinase activity
APL_1300	COG2814	Major facilitator Superfamily
APL_1302	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APL_1303	COG3115	cell septum assembly
APL_1305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APL_1309	COG2814	Major facilitator Superfamily
APL_1310	COG0363	glucosamine-6-phosphate deaminase activity
APL_1311	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APL_1312	COG1218	3'(2'),5'-bisphosphate nucleotidase
APL_1313	COG0494	nUDIX hydrolase
APL_1314	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APL_1315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APL_1316	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APL_1317	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APL_1318	COG0549	Belongs to the carbamate kinase family
APL_1320	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APL_1321	COG1178	ABC-type Fe3 transport system permease component
APL_1322	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APL_1323	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APL_1324	COG2190	(PTS) system
APL_1325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APL_1326	COG0210	DNA helicase
APL_1327	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APL_1328	COG0409	Hydrogenase expression formation protein
APL_1329	COG0309	Hydrogenase expression formation protein (HypE)
APL_1330	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APL_1331	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APL_1332	COG0437	4 iron, 4 sulfur cluster binding
APL_1333	COG5557	Pfam Polysulphide reductase, NrfD
APL_1334	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APL_1335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APL_1336	COG1773	rubredoxin
APL_1337	COG0298	carbon dioxide binding
APL_1338	COG0375	protein maturation
APL_1339	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APL_1340	COG0308	aminopeptidase N
APL_1341	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APL_1342	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APL_1343	COG0295	cytidine deaminase activity
APL_1344	COG2177	Part of the ABC transporter FtsEX involved in
APL_1345	COG2884	Cell division ATP-binding protein ftsE
APL_1346	COG0552	protein localization to endoplasmic reticulum
APL_1347	COG0742	ribosomal rna small subunit methyltransferase
APL_1348	COG3099	Belongs to the UPF0263 family
APL_1349	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APL_1351	COG4160	amino acid transport
APL_1352	COG4215	(ABC) transporter
APL_1353	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APL_1354	COG1126	abc transporter atp-binding protein
APL_1355	COG1881	PFAM PEBP family protein
APL_1357	COG3620	sequence-specific DNA binding
APL_1359	COG4232	protein-disulfide reductase activity
APL_1360	COG3101	peptidyl-lysine hydroxylation
APL_1362	COG3107	peptidoglycan biosynthetic process
APL_1363	COG0792	nuclease activity
APL_1364	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APL_1366	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
APL_1367	COG1138	Cytochrome C-type biogenesis protein
APL_1368	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APL_1369	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APL_1370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APL_1371	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APL_1372	COG4133	protoheme IX ABC transporter activity
APL_1373	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APL_1375	COG3630	sodium ion export across plasma membrane
APL_1377	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APL_1378	COG2824	Alkylphosphonate utilization operon protein PhnA
APL_1379	COG1858	cytochrome C peroxidase
APL_1380	COG1872	DUF167
APL_1381	COG0762	integral membrane protein
APL_1382	COG3171	Protein conserved in bacteria
APL_1383	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APL_1384	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APL_1385	COG0416	fatty acid biosynthetic process
APL_1386	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APL_1387	COG1399	metal-binding, possibly nucleic acid-binding protein
APL_1388	COG4137	Cytochrome C assembly protein
APL_1389	COG4536	flavin adenine dinucleotide binding
APL_1390	COG0733	neurotransmitter:sodium symporter activity
APL_1391	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APL_1391	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APL_1392	COG3715	PTS system
APL_1393	COG3716	PTS system mannose fructose sorbose family IID component
APL_1398	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APL_1399	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APL_1400	COG0049	tRNA binding
APL_1401	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APL_1402	COG0859	PFAM glycosyl transferase family 9
APL_1403	COG0859	PFAM glycosyl transferase family 9
APL_1405	COG3061	Opacity-associated protein A
APL_1405	COG3266	domain, Protein
APL_1406	COG1555	photosystem II stabilization
APL_1407	COG0688	phosphatidylethanolamine metabolic process
APL_1408	COG1181	Belongs to the D-alanine--D-alanine ligase family
APL_1408	COG2918	glutathione biosynthetic process
APL_1410	COG0814	amino acid
APL_1411	COG3691	Protein conserved in bacteria
APL_1412	COG4989	oxidoreductase activity
APL_1413	COG1022	Amp-dependent synthetase and ligase
APL_1414	COG0579	oxidoreductase
APL_1418	COG4211	Belongs to the binding-protein-dependent transport system permease family
APL_1419	COG1129	ABC transporter
APL_1420	COG1879	ABC-type sugar transport system periplasmic component
APL_1421	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APL_1421	COG2885	chlorophyll binding
APL_1422	COG0277	FAD linked oxidase domain protein
APL_1422	COG0247	lactate metabolic process
APL_1423	COG2050	protein possibly involved in aromatic compounds catabolism
APL_1425	COG3005	denitrification pathway
APL_1426	COG3043	anaerobic respiration
APL_1427	COG0348	domain, Protein
APL_1428	COG0437	4 iron, 4 sulfur cluster binding
APL_1429	COG0243	molybdopterin cofactor binding
APL_1431	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APL_1432	COG2249	NAD(P)H dehydrogenase (quinone) activity
APL_1433	COG2801	Transposase and inactivated derivatives
APL_1434	COG2963	transposase activity
APL_1436	COG1530	ribonuclease E activity
APL_1438	COG1755	Isoprenylcysteine carboxyl methyltransferase
APL_1439	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APL_1440	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APL_1446	COG1840	ABC-type Fe3 transport system, periplasmic component
APL_1449	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APL_1450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APL_1452	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APL_1453	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APL_1454	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APL_1457	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APL_1459	COG1720	tRNA m6t6A37 methyltransferase activity
APL_1460	COG4804	nuclease activity
APL_1461	COG1575	Belongs to the MenA family. Type 1 subfamily
APL_1462	COG0316	Belongs to the HesB IscA family
APL_1471	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APL_1472	COG1088	dTDP-glucose 4,6-dehydratase activity
APL_1473	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APL_1475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APL_1476	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APL_1478	COG0557	exoribonuclease II activity
APL_1479	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APL_1480	COG1309	transcriptional regulator
APL_1481	COG0583	DNA-binding transcription factor activity
APL_1482	COG0678	peroxiredoxin activity
APL_1482	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APL_1485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APL_1486	COG0825	malonyl-CoA metabolic process
APL_1488	COG0204	Acyl-transferase
APL_1489	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APL_1490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APL_1491	COG2848	UPF0210 protein
APL_1494	COG0783	Belongs to the Dps family
APL_1497	COG1289	transmembrane transporter activity
APL_1498	COG1803	Methylglyoxal synthase
APL_1499	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APL_1500	COG2963	transposase activity
APL_1501	COG2801	Transposase and inactivated derivatives
APL_1502	COG0525	valine-tRNA ligase activity
APL_1504	COG2153	protein acetylation
APL_1505	COG2927	DNA polymerase III (CHI subunit)
APL_1506	COG1652	LysM domain
APL_1507	COG0544	peptidyl-prolyl cis-trans isomerase activity
APL_1508	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APL_1509	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APL_1510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APL_1511	COG1045	serine acetyltransferase
APL_1512	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APL_1513	COG1072	(Pantothenic acid kinase))
APL_1514	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APL_1517	COG0521	Mo-molybdopterin cofactor biosynthetic process
APL_1519	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APL_1520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APL_1521	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APL_1524	COG0625	glutathione transferase activity
APL_1525	COG0019	diaminopimelate decarboxylase activity
APL_1526	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APL_1527	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APL_1528	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APL_1529	COG1053	succinate dehydrogenase
APL_1530	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APL_1531	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APL_1532	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APL_1533	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APL_1535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APL_1536	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APL_1537	COG2264	protein methyltransferase activity
APL_1541	COG0037	tRNA processing
APL_1542	COG4974	Belongs to the 'phage' integrase family
APL_1543	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APL_1546	COG1151	hydroxylamine reductase activity
APL_1547	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APL_1548	COG2244	polysaccharide biosynthetic process
APL_1549	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APL_1551	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APL_1552	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APL_1553	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APL_1555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APL_1557	COG0728	peptidoglycan biosynthetic process
APL_1558	COG0268	Binds directly to 16S ribosomal RNA
APL_1559	COG0569	domain protein
APL_1560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APL_1561	COG3276	selenocysteine insertion sequence binding
APL_1562	COG1921	L-seryl-tRNASec selenium transferase activity
APL_1563	COG0716	FMN binding
APL_1567	COG1629	transport
APL_1567	COG4771	TonB-dependent receptor
APL_1572	COG2431	L-lysine efflux transmembrane transporter activity
APL_1573	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APL_1574	COG3545	Serine hydrolase
APL_1576	COG0517	IMP dehydrogenase activity
APL_1576	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APL_1577	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APL_1586	COG1119	ATPase activity
APL_1587	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APL_1589	COG1739	Uncharacterized protein family UPF0029
APL_1590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APL_1591	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APL_1592	COG1970	mechanosensitive ion channel activity
APL_1593	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APL_1594	COG0321	lipoyl(octanoyl) transferase activity
APL_1595	COG2921	Belongs to the UPF0250 family
APL_1596	COG1686	Belongs to the peptidase S11 family
APL_1597	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APL_1598	COG0772	Belongs to the SEDS family
APL_1599	COG0768	penicillin binding
APL_1600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APL_1601	COG0799	negative regulation of ribosome biogenesis
APL_1602	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APL_1603	COG1126	abc transporter atp-binding protein
APL_1604	COG0765	amino acid transport
APL_1605	COG3681	Belongs to the UPF0597 family
APL_1606	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
APL_1608	COG3691	Protein conserved in bacteria
APL_1611	COG0829	nickel cation binding
APL_1612	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APL_1613	COG0830	nickel cation binding
APL_1616	COG0804	urea catabolic process
APL_1617	COG0832	Belongs to the urease beta subunit family
APL_1618	COG0831	urea catabolic process
APL_1620	COG1122	ATPase activity
APL_1621	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APL_1622	COG0310	cobalt ion transport
APL_1623	COG0310	cobalt ion transport
APL_1624	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
APL_1627	COG0490	domain, Protein
APL_1627	COG0471	metal ion transport
APL_1628	COG3722	fumarate hydratase activity
APL_1629	COG0246	Mannitol dehydrogenase
APL_1631	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APL_1632	COG1349	DNA-binding transcription factor activity
APL_1635	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
APL_1636	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APL_1637	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APL_1638	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APL_1639	COG2900	Belongs to the SlyX family
APL_1640	COG0545	Peptidyl-prolyl cis-trans isomerase
APL_1641	COG2964	Protein conserved in bacteria
APL_1642	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APL_1644	COG2168	tRNA wobble position uridine thiolation
APL_1645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APL_1646	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APL_1647	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APL_1648	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APL_1649	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APL_1650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APL_1652	COG0356	it plays a direct role in the translocation of protons across the membrane
APL_1654	COG0357	Ribosomal RNA small subunit methyltransferase G
APL_1655	COG0445	tRNA wobble uridine modification
APL_1656	COG0561	phosphatase activity
APL_1657	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APL_1658	COG3012	SEC-C Motif Domain Protein
APL_1660	COG3716	PTS system mannose fructose sorbose family IID component
APL_1661	COG3715	PTS system
APL_1662	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APL_1662	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APL_1663	COG2801	Transposase and inactivated derivatives
APL_1664	COG2963	transposase activity
APL_1665	COG2610	gluconate transmembrane transporter activity
APL_1666	COG3265	gluconokinase activity
APL_1667	COG1609	Transcriptional regulator
APL_1669	COG1869	D-ribose catabolic process
APL_1671	COG1172	Belongs to the binding-protein-dependent transport system permease family
APL_1672	COG1879	ABC-type sugar transport system periplasmic component
APL_1673	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APL_1674	COG0243	molybdopterin cofactor binding
APL_1675	COG0437	4 iron, 4 sulfur cluster binding
APL_1676	COG3302	dmso reductase anchor subunit
APL_1677	COG3381	protein complex oligomerization
APL_1678	COG2221	Nitrite and sulphite reductase 4Fe-4S
APL_1678	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APL_1683	COG1349	DNA-binding transcription factor activity
APL_1684	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
APL_1685	COG1070	Carbohydrate kinase
APL_1686	COG4154	Belongs to the RbsD FucU family
APL_1687	COG0235	Class ii aldolase
APL_1688	COG0738	Major facilitator superfamily
APL_1689	COG1454	alcohol dehydrogenase
APL_1690	COG3477	response to acidic pH
APL_1693	COG1126	abc transporter atp-binding protein
APL_1694	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APL_1698	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APL_1703	COG3623	hexulose-6-phosphate isomerase
APL_1704	COG0235	Class ii aldolase
APL_1705	COG0545	Peptidyl-prolyl cis-trans isomerase
APL_1710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APL_1712	COG0758	DNA mediated transformation
APL_1713	COG1297	OPT oligopeptide transporter protein
APL_1716	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APL_1718	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APL_1719	COG0081	regulation of translation
APL_1720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APL_1721	COG0222	ribosome binding
APL_1727	COG0085	RNA polymerase activity
APL_1728	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APL_1735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APL_1736	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APL_1737	COG1489	DNA binding
APL_1738	COG0346	lactoylglutathione lyase activity
APL_1739	COG1194	a g-specific adenine glycosylase
APL_1740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APL_1741	COG0741	lytic transglycosylase activity
APL_1742	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APL_1743	COG0737	Belongs to the 5'-nucleotidase family
APL_1744	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APL_1745	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APL_1746	COG3657	addiction module killer protein
APL_1747	COG0606	chelatase, subunit chli
APL_1749	COG2267	carboxylic ester hydrolase activity
APL_1750	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APL_1752	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APL_1754	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APL_1755	COG0363	glucosamine-6-phosphate deaminase activity
APL_1756	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APL_1759	COG0051	transcription antitermination factor activity, RNA binding
APL_1760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APL_1761	COG0088	Forms part of the polypeptide exit tunnel
APL_1762	COG0089	rRNA binding
APL_1763	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APL_1764	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APL_1765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APL_1766	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APL_1767	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APL_1768	COG0255	Belongs to the universal ribosomal protein uL29 family
APL_1769	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APL_1770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APL_1771	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APL_1772	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APL_1773	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APL_1774	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APL_1775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APL_1776	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APL_1777	COG1841	ribosomal large subunit assembly
APL_1778	COG0200	Binds to the 23S rRNA
APL_1779	COG0201	protein transport
APL_1780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APL_1781	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APL_1782	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APL_1783	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APL_1784	COG0202	RNA polymerase activity
APL_1786	COG0228	four-way junction DNA binding
APL_1787	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APL_1788	COG0336	Belongs to the RNA methyltransferase TrmD family
APL_1789	COG0335	large ribosomal subunit rRNA binding
APL_1790	COG2850	peptidyl-arginine hydroxylation
APL_1792	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APL_1800	COG0752	glycyl-tRNA synthetase alpha subunit
APL_1801	COG2852	Protein conserved in bacteria
APL_1803	COG0751	glycine-tRNA ligase activity
APL_1808	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APL_1810	COG0084	hydrolase, TatD family'
APL_1814	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APL_1816	COG0470	DNA polymerase III
APL_1817	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APL_1818	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APL_1819	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APL_1820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APL_1821	COG0254	rRNA binding
APL_1822	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APL_1823	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APL_1824	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APL_1825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APL_1826	COG1758	RNA polymerase activity
APL_1827	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APL_1830	COG0442	prolyl-tRNA aminoacylation
APL_1831	COG1595	DNA-templated transcription, initiation
APL_1832	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APL_1834	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APL_1837	COG2502	aspartate--ammonia ligase
APL_1838	COG1522	sequence-specific DNA binding
APL_1839	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APL_1841	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APL_1842	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APL_1845	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APL_1847	COG4208	sulfate ABC transporter
APL_1848	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APL_1849	COG1304	FMN binding
APL_1851	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APL_1853	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APL_1854	COG2995	paraquat-inducible protein a
APL_1855	COG1305	Transglutaminase-like
APL_1857	COG2608	mercury ion transmembrane transporter activity
APL_1859	COG1979	alcohol dehydrogenase
APL_1860	COG0583	DNA-binding transcription factor activity
APL_1861	COG2171	N-acyltransferase activity
APL_1862	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APL_1864	COG0511	ligase activity, forming carbon-carbon bonds
APL_1865	COG0439	Biotin carboxylase
APL_1867	COG3084	Protein conserved in bacteria
APL_1868	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APL_1870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APL_1870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APL_1871	COG0742	ribosomal rna small subunit methyltransferase
APL_1872	COG1876	peptidase activity
APL_1873	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APL_1874	COG1393	Belongs to the ArsC family
APL_1876	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APL_1877	COG0564	pseudouridine synthase activity
APL_1880	COG0668	transmembrane transport
APL_1881	COG0439	Biotin carboxylase
APL_1883	COG1025	Belongs to the peptidase M16 family
APL_1884	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APL_1889	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APL_1890	COG1067	ATP-dependent peptidase activity
APL_1891	COG3120	sequence-specific DNA binding
APL_1892	COG0180	Tryptophanyl-tRNA synthetase
APL_1895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APL_1896	COG0730	response to heat
APL_1897	COG0494	nUDIX hydrolase
APL_1899	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APL_1900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APL_1901	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APL_1902	COG2116	formate transmembrane transporter activity
APL_1905	COG0484	heat shock protein binding
APL_1906	COG0443	Heat shock 70 kDa protein
APL_1907	COG1070	Carbohydrate kinase
APL_1908	COG2115	Belongs to the xylose isomerase family
APL_1909	COG4213	ABC transporter substrate-binding protein
APL_1910	COG1129	ABC transporter
APL_1911	COG4214	carbohydrate transport
APL_1912	COG1609	Transcriptional regulator
APL_1912	COG2207	Transcriptional regulator
APL_1913	COG3590	peptidase
APL_1915	COG4145	pantothenate transmembrane transporter activity
APL_1916	COG3924	membrane
APL_1917	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
APL_1918	COG2853	Lipoprotein
APL_1919	COG0676	glucose-6-phosphate 1-epimerase activity
APL_1922	COG1649	PFAM Uncharacterised BCR, COG1649
APL_1922	COG0726	polysaccharide deacetylase
APL_1923	COG1215	transferase activity, transferring glycosyl groups
APL_1925	COG0149	triose-phosphate isomerase activity
APL_1927	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APL_1928	COG1238	metal cluster binding
APL_1930	COG1388	LysM domain
APL_1930	COG4942	peptidase
APL_1931	COG2818	Glycosylase
APL_1934	COG0700	Nucleoside recognition
APL_1935	COG3366	ferrous iron transmembrane transporter activity
APL_1937	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APL_1938	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APL_1939	COG0594	ribonuclease P activity
APL_1940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APL_1941	COG0174	glutamine synthetase
APL_1942	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APL_1943	COG0494	nUDIX hydrolase
APL_1944	COG3223	Belongs to the PsiE family
APL_1947	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APL_1949	COG1490	D-aminoacyl-tRNA deacylase activity
APL_1950	COG1295	ribonuclease BN
APL_1951	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APL_1959	COG1064	alcohol dehydrogenase
APL_1960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APL_1961	COG1923	regulation of RNA biosynthetic process
APL_1962	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APL_1964	COG1694	Mazg nucleotide pyrophosphohydrolase
APL_1967	COG1309	transcriptional regulator
APL_1968	COG0756	dUTP diphosphatase activity
APL_1969	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APL_1970	COG2003	Belongs to the UPF0758 family
APL_1971	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APL_1972	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APL_1974	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APL_1975	COG0076	glutamate decarboxylase activity
APL_1976	COG0425	Belongs to the sulfur carrier protein TusA family
APL_1977	COG2391	methyltransferase activity
APL_1978	COG3085	chromosome segregation
APL_1979	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APL_1981	COG0598	Magnesium transport protein CorA
APL_1982	COG2226	methyltransferase
APL_1984	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APL_1985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APL_1986	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APL_1987	COG0805	protein transport
APL_1990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APL_1991	COG1114	Component of the transport system for branched-chain amino acids
APL_1992	COG1028	Short-chain dehydrogenase reductase Sdr
APL_1993	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APL_1994	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APL_1995	COG0142	geranyltranstransferase activity
APL_1997	COG0431	NADPH-dependent FMN reductase
APL_1998	COG2259	Doxx family
APL_1999	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APL_2000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APL_2001	COG0697	spore germination
APL_2004	COG1040	competence protein
APL_2005	COG2813	Specifically methylates the guanine in position
APL_2007	COG0456	acetyltransferase
APL_2008	COG0513	Belongs to the DEAD box helicase family
APL_2009	COG0259	pyridoxamine-phosphate oxidase activity
APL_2010	COG0747	negative chemotaxis
APL_2012	COG1584	GPR1 FUN34 yaaH family protein
APL_2013	COG1120	ATPase activity
APL_2014	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APL_2016	COG4774	siderophore transport
APL_2018	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APL_2019	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APL_2020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APL_2021	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APL_2023	COG0131	Imidazoleglycerol-phosphate dehydratase
APL_2023	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APL_2024	COG4804	nuclease activity
APL_2025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APL_2026	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APL_2028	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APL_2028	COG0140	phosphoribosyl-ATP diphosphatase activity
APL_2029	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APL_2030	COG0024	Methionine aminopeptidase
APL_2033	COG1621	beta-fructofuranosidase activity
APL_2034	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APL_2036	COG4591	ABC-type transport system involved in lipoprotein release permease component
APL_2037	COG1136	(ABC) transporter
APL_2038	COG4591	ABC-type transport system involved in lipoprotein release permease component
APL_2039	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APL_2045	COG2897	thiosulfate sulfurtransferase activity
APL_2046	COG2391	methyltransferase activity