locus-tag class description APP7_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) APP7_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) APP7_0004 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) APP7_0005 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) APP7_0008 ENOG4105ERU peptidase APP7_0009 ENOG4108V6E Cell division protein mraZ APP7_0012 ENOG4105CJN penicillin-binding protein APP7_0013 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) APP7_0014 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) APP7_0016 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) APP7_0017 ENOG4105CNI cell division protein FtsW APP7_0020 ENOG4105CPF Cell wall formation (By similarity) APP7_0022 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) APP7_0023 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) APP7_0025 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) APP7_0026 ENOG4108JQ5 ABC transporter APP7_0027 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component APP7_0028 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component APP7_0034 ENOG4105C3G gtp-binding protein APP7_0037 ENOG4108XTF Outer Membrane Lipoprotein APP7_0038 ENOG4105NBI YecM protein APP7_0039 ENOG4105C75 arginyL-tRNA synthetase APP7_0041 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) APP7_0042 ENOG4105C2N RNA methyltransferase TrmH family group 3 APP7_0043 ENOG4105JIM Phosphatidylserine synthase APP7_0045 ENOG4105DTN riboflavin biosynthesis protein ribF APP7_0046 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase APP7_0047 ENOG4108VVQ metallophosphoesterase APP7_0048 ENOG41065U4 response regulator APP7_0050 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase APP7_0051 ENOG4105DFA alanine racemase domain protein APP7_0053 ENOG4105CI3 gtp-binding protein typa APP7_0054 ENOG41090BQ Glutaredoxin APP7_0056 ENOG4105DSJ YicC domain protein APP7_0057 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) APP7_0058 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding APP7_0059 ENOG4105WH1 Two component transcriptional regulator luxr family APP7_0061 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) APP7_0063 ENOG4105DEF Extracellular solute-binding protein, family 5 APP7_0064 ENOG4105DEF Extracellular solute-binding protein, family 5 APP7_0065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component APP7_0066 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component APP7_0067 ENOG4105C3U ABC transporter APP7_0068 ENOG4108JQ7 (ABC) transporter APP7_0071 ENOG4105M4H endoribonuclease L-psp APP7_0072 ENOG4105CM2 brancheD-chain amino acid aminotransferase APP7_0073 ENOG4105M2J Glutaredoxin APP7_0074 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) APP7_0075 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) APP7_0077 ENOG4105M15 transport protein ExbD APP7_0078 ENOG4105M8K biopolymer transport protein APP7_0080 ENOG4107QR8 Thioredoxin APP7_0081 ENOG4105VDH Dihydroxyacetone kinase APP7_0082 ENOG4108UTZ Dihydroxyacetone kinase APP7_0083 ENOG4105CMT Dihydroxyacetone kinase APP7_0084 ENOG4105C3M thioredoxin reductase APP7_0087 ENOG4108R99 pseudouridine synthase APP7_0089 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 APP7_0093 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) APP7_0097 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit APP7_0099 ENOG4105EAU Plays a role in nitrite reduction (By similarity) APP7_0100 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit APP7_0101 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein APP7_0102 ENOG4105DVI reductase, NrfD APP7_0104 ENOG4105EUR Domain-Containing protein APP7_0104 ENOG4105EUR Domain-Containing protein APP7_0104 ENOG4105EUR Domain-Containing protein APP7_0105 ENOG4105C2W permease APP7_0106 ENOG4105C26 Dehydrogenase APP7_0107 ENOG4105CK7 Sodium proline symporter APP7_0108 ENOG41069M3 Transcriptional regulator APP7_0109 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase APP7_0111 ENOG4105E07 UPF0149 protein APP7_0112 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) APP7_0113 ENOG4105R2J Conserved Protein APP7_0114 ENOG4105K70 DNA-binding protein APP7_0115 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) APP7_0119 ENOG4105VEQ Cold shock protein APP7_0120 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) APP7_0121 ENOG4105CN1 protease APP7_0123 ENOG4105DIT ErfK YbiS YcfS YnhG family protein APP7_0124 ENOG4105EAQ (twin-arginine translocation) pathway signal APP7_0125 ENOG4105C5X domain protein APP7_0128 ENOG4105K59 histidine triad (HIT) protein APP7_0129 ENOG4105CC5 ABC transporter APP7_0130 ENOG4105CC5 ABC transporter APP7_0132 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) APP7_0133 ENOG4105ETT transcriptional Regulator, LysR family APP7_0134 ENOG4105PAD Hydrolase APP7_0135 ENOG4107R11 Transcriptional regulator APP7_0137 ENOG4105HDK L-asparaginase APP7_0142 ENOG4107VHA regulatoR APP7_0143 ENOG4107QQ0 gntp family APP7_0144 ENOG4105BZW Glycerate kinase APP7_0145 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 APP7_0146 ENOG4105CPB ATP-dependent endonuclease of the OLD family APP7_0147 ENOG4105EWT decarboxylase family APP7_0148 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) APP7_0150 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) APP7_0151 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) APP7_0152 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) APP7_0153 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) APP7_0154 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) APP7_0155 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) APP7_0156 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) APP7_0157 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) APP7_0158 ENOG4105CJ2 (LipO)protein APP7_0161 ENOG4105D8G Major Facilitator superfamily APP7_0162 ENOG4105II7 pyrroline-5-carboxylate reductase APP7_0164 ENOG4107VXZ Hydrolase APP7_0168 ENOG4105DGN Electron transport complex APP7_0169 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) APP7_0170 ENOG4105EN6 Membrane APP7_0174 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase APP7_0176 ENOG4105DP9 ABC transporter APP7_0177 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters APP7_0178 ENOG4105DJ0 Poly(A) Polymerase APP7_0179 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase APP7_0181 ENOG4107H52 Dicarboxylate transport APP7_0183 ENOG4108UYE Lactoylglutathione lyase APP7_0184 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) APP7_0185 ENOG4105K3M )-transporter APP7_0186 ENOG4105EHE chorismate mutase- prephenate dehydrogenase APP7_0187 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) APP7_0188 ENOG4105DKP glycosyl transferase, family 9 APP7_0189 ENOG4105CA9 Pyruvate kinase APP7_0190 ENOG4108BY2 phosphohistidine phosphatase APP7_0191 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) APP7_0192 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) APP7_0193 ENOG4105C8J )-transporter APP7_0194 ENOG4105DFE Dna adenine methylase APP7_0195 ENOG4105D49 3-dehydroquinate synthase APP7_0196 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) APP7_0198 ENOG4108JQC penicillin-binding protein 1A APP7_0203 ENOG4105E4G Type IV pilus APP7_0204 ENOG4107YIM Involved in the transcription termination process (By similarity) APP7_0205 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) APP7_0206 ENOG4108ZAI phosphatidylglycerophosphatase a APP7_0207 ENOG4105CCF Lysine exporter protein (Lyse ygga) APP7_0208 ENOG4105EIB trna rrna methyltransferase APP7_0209 ENOG4105ECY inositol monophosphatase APP7_0210 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) APP7_0211 ENOG4105DQ6 Transposase APP7_0212 ENOG4105IYK transposase APP7_0214 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) APP7_0218 ENOG4105M6W Crispr-associated protein, Csy3 family APP7_0222 ENOG4106B0W Curli production assembly transport component CsgG APP7_0224 ENOG4107Y60 (LipO)protein APP7_0225 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) APP7_0226 ENOG41082NX 50s ribosomal protein l35 APP7_0228 ENOG4108QD6 APP7_0230 ENOG4105C37 (CBS) domain APP7_0231 ENOG4108W1A pseudouridine synthase APP7_0232 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) APP7_0234 ENOG4108UJU UPF0301 protein APP7_0235 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) APP7_0237 ENOG4105M85 Bola protein APP7_0242 ENOG4105M6F mutator MutT protein APP7_0243 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase APP7_0245 ENOG4105C8Y Acetylornithine aminotransferase APP7_0248 ENOG4108MVK Receptor APP7_0249 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) APP7_0250 ENOG4105C6T cysteine synthase APP7_0251 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) APP7_0252 ENOG4105CFH Aspartokinase APP7_0253 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) APP7_0254 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) APP7_0255 ENOG4107QYX exodeoxyribonuclease v alpha APP7_0256 ENOG4105CIN aminoacyl-histidine dipeptidase APP7_0257 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) APP7_0258 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) APP7_0259 ENOG4105ENJ RND efflux system, outer membrane lipoprotein APP7_0261 ENOG4108Z1B Cyclase dehydrase APP7_0262 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) APP7_0263 ENOG4105E0C molybdate abc transporter APP7_0264 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein APP7_0265 ENOG4105E3A (ABC) transporter APP7_0266 ENOG4105DA5 (ABC) transporter APP7_0267 ENOG4107QMP dna polymerase iii subunits gamma and tau APP7_0268 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) APP7_0270 ENOG4105KME endoribonuclease L-psp APP7_0272 ENOG4108KXH Ybak prolyl-tRNA synthetase associated APP7_0273 ENOG4105DIK (ABC) transporter APP7_0275 ENOG4108Z0T Part of a sulfur-relay system (By similarity) APP7_0276 ENOG4108MN8 Membrane APP7_0277 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase APP7_0280 ENOG4108RE7 deoxyribonuclease APP7_0281 ENOG4105C4R Atp-dependent dna helicase APP7_0282 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) APP7_0283 ENOG4105F38 ABC transporter, permease APP7_0284 ENOG4105D38 putrescine abc transporter APP7_0289 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APP7_0295 ENOG41082EK Restriction modification system DNA (Specificity APP7_0298 ENOG4105C5H ABC transporter APP7_0299 ENOG4105CUZ uba thif-type nad fad binding protein APP7_0301 ENOG4105C4M (Ubiquinol oxidase) subunit I APP7_0302 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii APP7_0303 ENOG4107YD3 Thioesterase APP7_0304 ENOG4105E02 MotA TolQ exbB proton channel APP7_0307 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) APP7_0308 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) APP7_0309 ENOG4105KCK Peptidoglycan-associated lipoprotein APP7_0311 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) APP7_0312 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) APP7_0313 ENOG4106K28 UPF0283 membrane protein APP7_0314 ENOG4105C5H ABC transporter APP7_0315 ENOG4105CVM Molybdenum cofactor synthesis domain protein APP7_0316 ENOG4105D06 uba thif-type nad fad binding protein APP7_0317 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) APP7_0318 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein APP7_0320 ENOG4105D3G Pseudouridine synthase APP7_0321 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase APP7_0322 ENOG4105D6S protein involved in catabolism of external DNA APP7_0323 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) APP7_0325 ENOG4105C28 cystathionine APP7_0326 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) APP7_0329 ENOG4105C9A Phoh family APP7_0331 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) APP7_0332 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) APP7_0334 ENOG4105D0A hydroxylase APP7_0338 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family APP7_0340 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN APP7_0341 ENOG4108IUZ ABC transporter APP7_0342 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA APP7_0344 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) APP7_0345 ENOG4108WV1 Pfam:DUF477 APP7_0347 ENOG4108V0P LemA family APP7_0348 ENOG4105DM4 PTS System APP7_0349 ENOG4105DE4 1-phosphofructokinase APP7_0350 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein APP7_0352 ENOG4108ESZ Glycogen debranching enzyme APP7_0353 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) APP7_0354 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) APP7_0355 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) APP7_0360 ENOG4105I08 Pseudouridine synthase APP7_0361 ENOG4105C2C drug resistance transporter, Bcr CflA APP7_0363 ENOG41088T4 Helicase IV APP7_0369 ENOG4108ZHR arsR family transcriptional regulator APP7_0370 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the APP7_0377 ENOG4105C2C drug resistance transporter, Bcr CflA APP7_0379 ENOG4107XHZ cytoplasmic chaperone TorD family protein APP7_0381 ENOG4107TT5 NLP P60 protein APP7_0383 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) APP7_0384 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) APP7_0385 ENOG4108MJ5 VirK protein APP7_0387 ENOG4105CQ7 ATP-dependent helicase APP7_0388 ENOG4108VMM UPF0756 membrane protein APP7_0390 ENOG4107RUE extracellular solute-binding protein family 1 APP7_0391 ENOG4107QI1 Mate efflux family protein APP7_0392 ENOG4107QKA exodeoxyribonuclease V beta APP7_0393 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) APP7_0394 ENOG4108JU5 Magnesium and cobalt efflux protein APP7_0395 ENOG4108Q67 UPF0319 protein APP7_0396 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) APP7_0397 ENOG4105F9F transposase APP7_0398 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) APP7_0399 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) APP7_0400 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) APP7_0401 ENOG4105CXY transporter APP7_0402 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase APP7_0403 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A APP7_0404 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B APP7_0405 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) APP7_0406 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) APP7_0407 ENOG4108R6K riboflavin synthase, subunit alpha APP7_0410 ENOG4108RRZ Transcription elongation factor GreB APP7_0411 ENOG4105C2X Arabinose 5-phosphate isomerase APP7_0413 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family APP7_0414 ENOG4105C09 Bile acid APP7_0415 ENOG4105ENT Efflux transporter rnd family, mfp subunit APP7_0416 ENOG4105DQF Hydrolase APP7_0417 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) APP7_0418 ENOG4105EMN RNA polymerase sigma factor APP7_0419 ENOG41069PW sigma-e factor negative regulatory protein APP7_0421 ENOG4105CEY Amp-dependent synthetase and ligase APP7_0422 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) APP7_0424 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) APP7_0425 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) APP7_0426 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) APP7_0429 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) APP7_0432 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) APP7_0433 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) APP7_0435 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane APP7_0436 ENOG4105DZP Membrane-associated zinc metalloprotease APP7_0437 ENOG4105KNE Phosphatidate cytidylyltransferase APP7_0438 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) APP7_0441 ENOG4105EYK Phosphatidylglycerophosphatase B APP7_0442 ENOG4105HBR Rna-binding protein APP7_0443 ENOG4106WTF Glycosyl transferase, family 2 APP7_0444 ENOG41061WM D-Alanyl-D-Alanine APP7_0445 ENOG4105M5K heptosyltransferase APP7_0447 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) APP7_0448 ENOG4105E96 Colicin v production protein APP7_0449 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase APP7_0451 ENOG4105D82 Glutamate dehydrogenase APP7_0452 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) APP7_0454 ENOG4105KME endoribonuclease L-psp APP7_0455 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase APP7_0456 ENOG4108KU3 Integrase APP7_0467 ENOG4108PNI recT protein APP7_0486 ENOG4105NVB glycoside hydrolase, family 19 APP7_0491 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) APP7_0508 ENOG4105E0X reductase APP7_0509 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase APP7_0510 ENOG4105DFF Rod shape-determining protein mreb APP7_0511 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) APP7_0513 ENOG4105D1H recombination factor protein RarA APP7_0514 ENOG4105FAV ABC, transporter APP7_0515 ENOG4105E7A Glutamine amidotransferase APP7_0516 ENOG4105DWV Homoserine O-trans-acetylase APP7_0517 ENOG4107GZ4 SanA protein APP7_0518 ENOG4105EUR Domain-Containing protein APP7_0519 ENOG4105F9F transposase APP7_0521 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) APP7_0522 ENOG4107QR9 Iron-sulfur cluster binding protein APP7_0523 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) APP7_0524 ENOG4105DAA L-lactate APP7_0525 ENOG4108SAU DNA-binding protein H-ns APP7_0526 ENOG4107S6Z Na H antiporter APP7_0527 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator APP7_0528 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha APP7_0530 ENOG4108MJ5 VirK protein APP7_0531 ENOG4105C7S Dehydrogenase APP7_0532 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 APP7_0533 ENOG4105FDK ABC transporter APP7_0534 ENOG4105DR5 peptidase APP7_0535 ENOG4105T95 Thiol disulfide interChange protein APP7_0536 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) APP7_0538 ENOG4108K4B hydrolase APP7_0539 ENOG4105BZU Histidine kinase APP7_0541 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) APP7_0543 ENOG4105CKU formyltetrahydrofolate synthetase APP7_0544 ENOG4108ZZ3 UPF0260 protein APP7_0545 ENOG4105EMU Dehydrogenase APP7_0548 ENOG4105X5T APP7_0550 ENOG4105C2M dna polymerase I APP7_0552 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) APP7_0554 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase APP7_0560 ENOG41080HT Transcriptional regulator, arsr family APP7_0563 ENOG41080C8 DUF218 domain APP7_0564 ENOG4105C6K Malic enzyme APP7_0566 ENOG41065CD Exported protein APP7_0567 ENOG4105D7X high-affinity nickel-transporter APP7_0568 ENOG4105BZG amino acid carrier protein APP7_0569 ENOG4108YI8 ABC transporter APP7_0570 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component APP7_0571 ENOG4105D06 uba thif-type nad fad binding protein APP7_0572 ENOG4105D06 uba thif-type nad fad binding protein APP7_0573 ENOG4105WHD thiamine biosynthesis protein ThiS APP7_0574 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) APP7_0575 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) APP7_0576 ENOG4105D41 biosynthesis protein thiH APP7_0577 ENOG4105ETU transcriptional activator (TenA APP7_0578 ENOG4107Z6I Thiamine biosynthesis protein APP7_0579 ENOG4107Z6I Thiamine biosynthesis protein APP7_0580 ENOG4105DWF phosphomethylpyrimidine kinase APP7_0581 ENOG4105DWF phosphomethylpyrimidine kinase APP7_0583 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) APP7_0584 ENOG4105C3F Signal peptidase i APP7_0585 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) APP7_0586 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) APP7_0601 ENOG4105C1J atp-dependent rna helicase APP7_0603 ENOG4105D7A ATP-binding protein APP7_0604 ENOG4105C4Y ABC transporter APP7_0605 ENOG4107RCV ABC transporter, permease APP7_0609 ENOG4105CQ0 ABC transporter APP7_0611 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) APP7_0612 ENOG4108I6E Sulfatase APP7_0613 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) APP7_0614 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) APP7_0615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family APP7_0618 ENOG4108Z6B deaminase APP7_0619 ENOG4105C1J atp-dependent rna helicase APP7_0620 ENOG4105RT1 May be involved in cell division (By similarity) APP7_0621 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) APP7_0622 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APP7_0624 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) APP7_0627 ENOG4105E68 Sulfatase APP7_0628 ENOG4105YDX UPF0352 protein APP7_0629 ENOG4105Y7M Transcriptional regulator, TetR family APP7_0630 ENOG410624X efflux transporter, rnd family, mfp subunit APP7_0631 ENOG4105BZS acriflavin resistance protein APP7_0632 ENOG4105BZS acriflavin resistance protein APP7_0635 ENOG4105TWJ Domain of unknown function (DUF1919) APP7_0636 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain APP7_0639 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) APP7_0640 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) APP7_0641 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) APP7_0642 ENOG4105E0U tyrosine-specific transport protein APP7_0643 ENOG4105E0U tyrosine-specific transport protein APP7_0645 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III APP7_0646 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) APP7_0650 ENOG41076HS cation diffusion facilitator family transporter APP7_0651 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein APP7_0652 ENOG4107R6U sodium dicarboxylate symporter APP7_0653 ENOG4108RCM Nitroreductase APP7_0655 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) APP7_0656 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) APP7_0657 ENOG4108QBX (LipO)protein APP7_0658 ENOG4105DQ6 Transposase APP7_0659 ENOG4105IYK transposase APP7_0660 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) APP7_0661 ENOG4105E2R ROK family APP7_0662 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) APP7_0663 ENOG4105EW9 transcriptional regulator AsnC family APP7_0664 ENOG4105CNU cell division protein FtsK APP7_0665 ENOG4105CGZ zinc metallopeptidase APP7_0666 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) APP7_0667 ENOG41072GX Peptidase M22 Glycoprotease APP7_0668 ENOG4107104 thymidine kinase APP7_0669 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) APP7_0670 ENOG4105CBT Fructose-1,6-bisphosphatase APP7_0671 ENOG4107QNR UPF0135 protein APP7_0672 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) APP7_0673 ENOG4105E0F Histidine kinase APP7_0674 ENOG4105E3W Two component transcriptional regulator (Winged helix family APP7_0675 ENOG4105DXN mazG family APP7_0677 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase APP7_0678 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) APP7_0679 ENOG4105CHV Transcription elongation factor NusA APP7_0680 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) APP7_0681 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) APP7_0682 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) APP7_0683 ENOG4105CVE Lytic murein transglycosylase APP7_0684 ENOG4107EPN Domain of unknown function (DUF1508) APP7_0685 ENOG4108DNC Involved in acetate metabolism (By similarity) APP7_0687 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic APP7_0691 ENOG4108J3C UTP-glucose-1-phosphate uridylyltransferase APP7_0693 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) APP7_0696 ENOG4105DS0 Transcriptional regulator, Crp Fnr family APP7_0697 ENOG4105KB2 stringent starvation protein b APP7_0698 ENOG4107MKT Stringent starvation protein a APP7_0699 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) APP7_0700 ENOG4105HDK L-asparaginase APP7_0701 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit APP7_0702 ENOG4105CGF Aromatic amino acid aminotransferase APP7_0703 ENOG4107RAQ aminopeptidase APP7_0707 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) APP7_0708 ENOG410650H (LipO)protein APP7_0709 ENOG4105DBE peroxidase APP7_0711 ENOG4105DB7 PHP domain protein APP7_0713 ENOG4105CJB Exodeoxyribonuclease I APP7_0715 ENOG4105C5S asparaginyl-tRNA synthetase APP7_0716 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein APP7_0718 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) APP7_0719 ENOG4105CX6 glutaminyL-tRNA synthetase APP7_0720 ENOG4105C0R drug resistance transporter emrb qaca subfamily APP7_0721 ENOG4107SC1 transglycosylase APP7_0722 ENOG4108UGV hypoxanthine phosphoribosyltransferase APP7_0723 ENOG4105C28 cystathionine APP7_0724 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) APP7_0728 ENOG4105M08 Membrane APP7_0729 ENOG4105CXG d-lactate dehydrogenase APP7_0730 ENOG4107QY8 reductase APP7_0731 ENOG4105CUW cytochrome C-TYPE protein APP7_0733 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) APP7_0734 ENOG4105M00 molybdopterin converting factor, subunit 1 APP7_0735 ENOG4108ZAF Molybdopterin APP7_0736 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) APP7_0737 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) APP7_0738 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) APP7_0739 ENOG4105CC0 LysR family Transcriptional regulator APP7_0744 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) APP7_0745 ENOG4105C0D helicase APP7_0748 ENOG4105QEK Transcriptional regulator APP7_0749 ENOG4108R66 Conserved Protein APP7_0750 ENOG4105C9X ppx gppa phosphatase APP7_0752 ENOG4105CFH Aspartokinase APP7_0753 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) APP7_0754 ENOG4105VNG YcgL domain-containing protein APP7_0755 ENOG4105CDU Replicative dna helicase APP7_0757 ENOG4105DHS permease protein APP7_0758 ENOG4105CM4 permease protein APP7_0759 ENOG4108IPW abc transporter atp-binding protein APP7_0760 ENOG4107IX6 phosphate transport regulator APP7_0761 ENOG4105CJ3 phosphate transporter APP7_0764 ENOG4105NSG hemerythrin hhe cation binding domain protein APP7_0765 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) APP7_0768 ENOG4105VEQ Cold shock protein APP7_0769 ENOG41077A9 carbonic anhydrase APP7_0770 ENOG4105C7K acetolactate synthase APP7_0771 ENOG4108ZP8 Acetolactate synthase small subunit APP7_0772 ENOG4105CMS peptidase U62, modulator of DNA gyrase APP7_0773 ENOG4105N42 UPF0307 protein APP7_0775 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase APP7_0776 ENOG4108UQV Membrane APP7_0777 ENOG4108ZPB UPF0306 protein APP7_0778 ENOG4108ZJT translation initiation factor, Sui1 APP7_0779 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) APP7_0780 ENOG4105CFV Tetratricopeptide repeat protein APP7_0781 ENOG4105Q4A inner membrane protein yciS APP7_0782 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) APP7_0783 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) APP7_0784 ENOG4105CAT Cytidine monophosphate kinase APP7_0785 ENOG4105C0H protease APP7_0786 ENOG4105C0H protease APP7_0788 ENOG4108IYH Dna topoisomerase APP7_0789 ENOG4105G6Z alkaline phosphatase APP7_0790 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) APP7_0792 ENOG4105EGS Mechanosensitive ion channel APP7_0793 ENOG4105EGS Mechanosensitive ion channel APP7_0794 ENOG4105CEY Amp-dependent synthetase and ligase APP7_0795 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) APP7_0796 ENOG4105EV9 Alpha Beta Hydrolase APP7_0798 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH APP7_0802 ENOG4105VAW lrga family APP7_0803 ENOG41067MG lrgb family APP7_0804 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) APP7_0805 ENOG4105DFP Integrase APP7_0815 ENOG4105CAR Terminase, large subunit APP7_0823 ENOG4105DVA methyltransferase APP7_0825 ENOG4105CHW UPF0052 protein APP7_0827 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 APP7_0828 ENOG4108IYC Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) APP7_0829 ENOG41080IJ Diacylglycerol kinase APP7_0830 ENOG4105CGH 5'-nucleotidase APP7_0832 ENOG4107QN2 dihydrolipoyl dehydrogenase APP7_0833 ENOG4107QSN dihydrolipoamide acetyltransferase APP7_0834 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) APP7_0836 ENOG4105C5T Phosphoribosyl pyrophosphate synthase APP7_0839 ENOG4105BZ1 (ABC) transporter APP7_0840 ENOG41067MG lrgb family APP7_0842 ENOG4105DVT helicase APP7_0844 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) APP7_0845 ENOG4108UUM single-stranded DNA-binding protein APP7_0850 ENOG4105EA8 2-Nitropropane dioxygenase APP7_0852 ENOG4105UNS Pfam:DUF419 APP7_0853 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein APP7_0854 ENOG4108EU3 peptide transport system, permease APP7_0856 ENOG4108EVY peptide transport periplasmic protein APP7_0857 ENOG4108JU8 Transcriptional regulator APP7_0858 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) APP7_0860 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) APP7_0863 ENOG4105E0M Sulfatase APP7_0864 ENOG4105QVC MOSC domain-containing protein APP7_0866 ENOG4105CTB Polyprenyl synthetase APP7_0869 ENOG4105C03 ribonuclease APP7_0870 ENOG4105DDY UPF0142 protein ycaO APP7_0873 ENOG4105CA3 membrane-bound lytic murein transglycosylase APP7_0875 ENOG4105VT2 5-hydroxyisourate hydrolase APP7_0876 ENOG4105ETE Transcriptional regulator (LacI family APP7_0877 ENOG4108VD1 dedA family APP7_0878 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APP7_0879 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) APP7_0880 ENOG4105E98 transcriptional regulator DeoR family APP7_0881 ENOG4107QTF adenylosuccinate lyase APP7_0882 ENOG41075W9 High frequency lysogenization protein HflD homolog APP7_0883 ENOG4108JJ8 (ABC) transporter APP7_0884 ENOG4108JJ9 ABC, transporter APP7_0885 ENOG4105MA0 exported protein APP7_0886 ENOG4105CFU surface antigen APP7_0887 ENOG4105PXI polysaccharide deacetylase APP7_0888 ENOG41063SB peptidase APP7_0889 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) APP7_0891 ENOG4105DBI uridine monophosphokinase APP7_0892 ENOG4105DHP deoxycytidine triphosphate deaminase APP7_0894 ENOG4105D0S secretion protein (HlyD APP7_0895 ENOG4105CJ1 ABC, transporter APP7_0896 ENOG4105CMI transporter APP7_0898 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) APP7_0899 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) APP7_0900 ENOG4105CVS RNA methyltransferase TrmH family, group 1 APP7_0902 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase APP7_0903 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen APP7_0904 ENOG4105CSA Coproporphyrinogen iii oxidase APP7_0905 ENOG4107QSI ABC, transporter APP7_0906 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component APP7_0909 ENOG4108JQ7 (ABC) transporter APP7_0912 ENOG4105SYT Methylenetetrahydrofolate reductase APP7_0913 ENOG4105DEF Extracellular solute-binding protein, family 5 APP7_0914 ENOG4105C44 Serine transporter APP7_0915 ENOG4105EJQ L-serine dehydratase APP7_0917 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) APP7_0918 ENOG4105DK0 Indole-3-glycerol phosphate synthase APP7_0920 ENOG4105WP7 tRNA pseudouridine synthase C APP7_0921 ENOG4105DR9 pseudouridine synthase APP7_0924 ENOG4105I7R Adenylate cyclase APP7_0925 ENOG4105CM6 amino acid regulated cytosolic protein APP7_0926 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) APP7_0928 ENOG4105CH2 amidohydrolase APP7_0933 ENOG4105DJF DNA polymerase III, delta' subunit APP7_0934 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) APP7_0935 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) APP7_0937 ENOG4105D7Q type ii secretion system APP7_0938 ENOG4107QHF type ii secretion system protein e APP7_0940 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) APP7_0942 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) APP7_0943 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) APP7_0944 ENOG4105EJ9 Membrane APP7_0945 ENOG4105CSM endonuclease III APP7_0950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) APP7_0951 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) APP7_0952 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) APP7_0953 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein APP7_0954 ENOG4108MG3 formate dehydrogenase APP7_0955 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) APP7_0959 ENOG4105D1S lipid A biosynthesis APP7_0960 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA APP7_0962 ENOG4105EUJ GTP cyclohydrolase i APP7_0963 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) APP7_0965 ENOG4108UW5 maltose o-acetyltransferase APP7_0966 ENOG4105ENX hydrolase APP7_0967 ENOG4105ENX hydrolase APP7_0968 ENOG4105EQ2 LysR family Transcriptional regulator APP7_0969 ENOG4105D01 (LipO)protein APP7_0970 ENOG4105D01 (LipO)protein APP7_0971 ENOG4108UMI ABC transporter, permease APP7_0972 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) APP7_0974 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) APP7_0975 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate APP7_0976 ENOG4105IYK transposase APP7_0977 ENOG4105DQ6 Transposase APP7_0978 ENOG4105UGU tonB-dependent Receptor APP7_0981 ENOG4105WVQ Fe-S assembly protein IscX APP7_0982 ENOG4108ZIT Ferredoxin, 2FE-2S APP7_0984 ENOG4108RF1 Protein of unknown function DUF2625 APP7_0986 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) APP7_0987 ENOG4108Z4V iron-sulfur cluster assembly APP7_0988 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins APP7_0989 ENOG4105C3J Cysteine desulfurase APP7_0990 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family APP7_0991 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation APP7_0992 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) APP7_0993 ENOG4105BZU Histidine kinase APP7_0994 ENOG4108TZV Membrane APP7_0995 ENOG4108DG9 Smr protein MutS2 APP7_0996 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) APP7_0997 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) APP7_0998 ENOG4105HSA Protein of unknown function (DUF452) APP7_0999 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) APP7_1000 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) APP7_1001 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) APP7_1002 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) APP7_1003 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase APP7_1006 ENOG4108J1Q APP7_1010 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) APP7_1011 ENOG4105DC1 bifunctional purine biosynthesis protein purh APP7_1012 ENOG4108J1Q APP7_1014 ENOG4105CKT filamentous hemagglutinin APP7_1015 ENOG4105D5K Hemolysin activator protein APP7_1016 ENOG4105D5K Hemolysin activator protein APP7_1018 ENOG4105D4P Coproporphyrinogen iii oxidase APP7_1022 ENOG4105D6U Sodium Glutamate Symporter APP7_1024 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) APP7_1025 ENOG4105K9H YciI-like protein APP7_1026 ENOG4105NAU thioesterase Superfamily protein APP7_1029 ENOG4105PQ6 UPF0208 membrane protein APP7_1032 ENOG4105D3Y Na H antiporter APP7_1033 ENOG4105CGK Exodeoxyribonuclease III APP7_1034 ENOG4105EMY transcriptional regulator APP7_1038 ENOG4105VFB Binds the 23S rRNA (By similarity) APP7_1039 ENOG4105CV1 Transketolase (EC 2.2.1.1) APP7_1041 ENOG4105CH6 catalase APP7_1042 ENOG4105IYK transposase APP7_1043 ENOG4105DQ6 Transposase APP7_1044 ENOG4107RN3 metallophosphoesterase APP7_1045 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) APP7_1046 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) APP7_1047 ENOG4105F0Z galactose-1-phosphate uridylyltransferase APP7_1049 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) APP7_1050 ENOG4105CNT hydrolase family 2 APP7_1054 ENOG4105F9F transposase APP7_1057 ENOG4105D1F ATP-binding protein APP7_1059 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein APP7_1060 ENOG4105EIN peptidylprolyl cis-trans isomerase APP7_1061 ENOG4105EEQ Na H antiporter APP7_1062 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) APP7_1063 ENOG4105CKW Inner membrane protein yedI APP7_1064 ENOG410601J HemY protein APP7_1065 ENOG4105ECF c-methyltransferase APP7_1066 ENOG41076E6 Uroporphyrinogen-III Synthase APP7_1067 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) APP7_1068 ENOG4108EKI Dehydrogenase APP7_1071 ENOG4105D3A purine nucleoside phosphorylase DeoD-type APP7_1073 ENOG4105D9N nucleoside APP7_1074 ENOG4108VW9 Membrane APP7_1075 ENOG4108UHU Aldolase APP7_1076 ENOG4107SS6 2-dehydro-3-deoxygluconokinase APP7_1077 ENOG4105D2H Uronic isomerase APP7_1079 ENOG4107YCY Transcriptional regulator APP7_1080 ENOG4105E0X reductase APP7_1081 ENOG4108RYC glycosyltransferase APP7_1082 ENOG4108RJ9 Glycosyl transferase, family 2 APP7_1084 ENOG41068D6 Glycosyltransferase APP7_1086 ENOG4108ZPC Polysaccharide pyruvyl transferase APP7_1087 ENOG41080C8 DUF218 domain APP7_1088 ENOG4105C25 Primosomal protein n' APP7_1089 ENOG4105CQC Prephenate dehydratase APP7_1090 ENOG4105DGW oligopeptidase A APP7_1091 ENOG4105F1A Pyruvate formate-lyase APP7_1092 ENOG4105C6N Formate acetyltransferase APP7_1093 ENOG4105TMB Formate nitrite transporter APP7_1094 ENOG4105W39 Membrane APP7_1095 ENOG4105D0M Protease HtpX homolog APP7_1097 ENOG4105DWU Membrane APP7_1098 ENOG4105E4F Isochorismate synthase APP7_1099 ENOG4105CHM Aminotransferase APP7_1100 ENOG4105DTR rard protein APP7_1101 ENOG4105DTR rard protein APP7_1102 ENOG4105N14 lysine exporter protein LysE YggA APP7_1104 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related APP7_1106 ENOG4108DMF Cytochrome C biogenesis protein APP7_1107 ENOG4107QX9 Thiol disulfide interChange protein APP7_1108 ENOG4105DA4 cytochrome c-type biogenesis protein APP7_1109 ENOG4105CKD glutathione-regulated potassium-efflux system protein APP7_1110 ENOG4105CKD glutathione-regulated potassium-efflux system protein APP7_1111 ENOG4107T0K Adenylate cyclase APP7_1112 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) APP7_1113 ENOG4105IYK transposase APP7_1114 ENOG4105IYK transposase APP7_1115 ENOG4105DQ6 Transposase APP7_1116 ENOG4105DQ6 Transposase APP7_1117 ENOG4105WXI Bacterial OB fold (BOF) protein APP7_1121 ENOG4105XJC Two component transcriptional regulator (Winged helix family APP7_1122 ENOG4105DHQ Histidine kinase APP7_1123 ENOG4108UUE Transcriptional regulator APP7_1124 ENOG4105VIE preprotein translocase, subunit YajC APP7_1125 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) APP7_1126 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) APP7_1127 ENOG41090A1 ferritin APP7_1128 ENOG41090A1 ferritin APP7_1129 ENOG4105C7N Xanthine uracil vitamin C permease APP7_1130 ENOG4108Z03 MAF-like protein APP7_1132 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) APP7_1134 ENOG4105EPW hflc protein APP7_1135 ENOG4107QJR hflk protein APP7_1136 ENOG4105K63 Thioredoxin APP7_1140 ENOG4105D5Q Arginine ornithine antiporter APP7_1141 ENOG4105D5Q Arginine ornithine antiporter APP7_1143 ENOG4105CWC Acetylornithine deacetylase APP7_1144 ENOG4105EIF outer membrane protein W APP7_1145 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit APP7_1146 ENOG4105D6J arsenicaL-resistance protein APP7_1147 ENOG4105K89 arsenate reductase APP7_1149 ENOG4108IJ0 Aspartate ammonia-lyase APP7_1151 ENOG4105CXB phosphoribosylaminoimidazole synthetase APP7_1152 ENOG41069UX Beta-N-acetyl-hexosaminidase APP7_1154 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase APP7_1155 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) APP7_1159 ENOG4108M8S permease YjgP YjgQ family protein APP7_1160 ENOG4108K5H permease YjgP YjgQ family protein APP7_1161 ENOG4105C0B DNA polymerase III (alpha subunit) APP7_1162 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR APP7_1163 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR APP7_1167 ENOG4105EE5 Membrane protein terC APP7_1168 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) APP7_1169 ENOG4105F9F transposase APP7_1171 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) APP7_1173 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) APP7_1174 ENOG4105C9U ATP-dependent DNA helicase RecQ APP7_1176 ENOG4107J0A lipopolysaccharide biosynthetic process APP7_1177 ENOG4107J0A lipopolysaccharide biosynthetic process APP7_1178 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) APP7_1179 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane APP7_1180 ENOG4105C34 Pseudouridine synthase APP7_1181 ENOG4108VTV Inherit from NOG: Membrane APP7_1182 ENOG4105CTQ phosphohexokinase APP7_1183 ENOG4105C9B Cysteine desulfurase APP7_1184 ENOG4105KK6 nuclease APP7_1185 ENOG4105BZG amino acid carrier protein APP7_1186 ENOG4105DSF transport protein APP7_1188 ENOG4105CFP Peptidase U32 APP7_1189 ENOG4105PF3 O-Antigen polymerase APP7_1190 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase APP7_1192 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) APP7_1193 ENOG4105K8N protein family UPF0079, ATPase APP7_1194 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase APP7_1195 ENOG4107QP8 phosphohexose isomerase APP7_1196 ENOG4105W0Z cytoplasmic protein APP7_1197 ENOG4105E2X shikimate dehydrogenase APP7_1200 ENOG41060QA UPF0267 protein APP7_1201 ENOG4105Y3E Modulates RecA activity (By similarity) APP7_1202 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) APP7_1204 ENOG4105CRQ synthase (Component I) APP7_1205 ENOG4105CGY Dna recombination protein APP7_1206 ENOG4105DDQ anthranilate synthase APP7_1209 ENOG4108TIT dATP pyrophosphohydrolase APP7_1210 ENOG4105CDY transcriptional regulatory protein APP7_1212 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) APP7_1213 ENOG4107RAN Peptidase, M16 APP7_1215 ENOG4107QPK )-transporter APP7_1216 ENOG4105DZ2 Transcriptional regulator APP7_1217 ENOG4106ZV1 Transferrin binding protein-like solute binding protein APP7_1218 ENOG4105FE9 pseudouridine synthase APP7_1219 ENOG4107RTD sua5 ycio yrdc ywlc family protein APP7_1220 ENOG4105EZR dyp-type peroxidase family protein APP7_1221 ENOG4105CRQ synthase (Component I) APP7_1222 ENOG4105DDQ anthranilate synthase APP7_1224 ENOG4105DMQ Methyltransferase APP7_1225 ENOG4105RHG APP7_1226 ENOG4105Z2P Protein of unknown function (DUF465) APP7_1229 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) APP7_1231 ENOG4105C12 Phosphoribosylglycinamide synthetase APP7_1233 ENOG4105N21 Membrane APP7_1235 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) APP7_1236 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) APP7_1237 ENOG4105CHH sulfate transporter APP7_1239 ENOG4105D9R oxidoreductase APP7_1240 ENOG4105CKD glutathione-regulated potassium-efflux system protein APP7_1243 ENOG4105EXG Transcriptional regulator APP7_1246 ENOG4105CF7 AraC family transcriptional regulator APP7_1248 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase APP7_1249 ENOG4105DEN Luciferase family APP7_1251 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase APP7_1252 ENOG4108RCM Nitroreductase APP7_1253 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein APP7_1255 ENOG4105C4W S-formylglutathione hydrolase APP7_1260 ENOG4105C94 Transporter APP7_1263 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein APP7_1264 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 APP7_1266 ENOG4105BZ1 (ABC) transporter APP7_1267 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) APP7_1268 ENOG4105DY2 Paraquat-inducible protein b APP7_1269 ENOG41090R7 Ferric uptake APP7_1270 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) APP7_1271 ENOG4105NNH LexA regulated protein APP7_1272 ENOG4108Z66 YbaK ebsC protein APP7_1273 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) APP7_1274 ENOG4105C7N Xanthine uracil vitamin C permease APP7_1275 ENOG41090EX DsrE family APP7_1276 ENOG4105CBX hi0933 family APP7_1277 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) APP7_1278 ENOG41062Z9 Membrane APP7_1279 ENOG4105EAC phosphoserine phosphatase APP7_1282 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) APP7_1283 ENOG41061ZR Transcriptional regulator APP7_1284 ENOG4107W52 maltose operon periplasmic protein APP7_1285 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) APP7_1286 ENOG4108IJ9 (ABC) transporter APP7_1287 ENOG4107FKK extracellular solute-binding protein family 1 APP7_1288 ENOG4105D56 permease protein APP7_1289 ENOG4105EG2 ABC transporter, permease APP7_1290 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) APP7_1292 ENOG4105EYA deoxyribonuclease APP7_1293 ENOG4105DC8 reductase APP7_1294 ENOG4108TEB UPF0114 protein APP7_1295 ENOG4108TVJ Nitroreductase APP7_1299 ENOG4105D2N Aldolase APP7_1300 ENOG4105BZA Phosphoglycerate kinase APP7_1301 ENOG4105C8P )-transporter APP7_1302 ENOG4105C8P )-transporter APP7_1303 ENOG4105C8P )-transporter APP7_1304 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) APP7_1305 ENOG4105BZU Histidine kinase APP7_1306 ENOG4105CK6 Two component transcriptional regulator (Winged helix family APP7_1307 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) APP7_1308 ENOG4105E2Z phosphate ABC transporter (Permease APP7_1309 ENOG4105E2Z phosphate ABC transporter (Permease APP7_1310 ENOG4105C8U phosphate abc transporter APP7_1311 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) APP7_1312 ENOG4108Z6Z Transcriptional regulator APP7_1315 ENOG4105C59 p-type ATPase APP7_1316 ENOG4105E1F short-chain dehydrogenase reductase APP7_1317 ENOG41069NU Nitroreductase APP7_1318 ENOG4105D07 Signal peptide peptidase, SppA APP7_1319 ENOG41083KI ribonuclease, T2 APP7_1320 ENOG4105GPY SprT protein APP7_1321 ENOG4105CEP NADH dehydrogenase APP7_1322 ENOG4105BZM domain protein APP7_1323 ENOG41090FY type IV pilus biogenesis stability protein PilW APP7_1324 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs APP7_1327 ENOG4105W49 UPF0434 protein APP7_1329 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) APP7_1331 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) APP7_1332 ENOG4108JDX DNA polymerase iii, epsilon subunit APP7_1333 ENOG4105C5H ABC transporter APP7_1338 ENOG4105VFK BolA family APP7_1340 ENOG4105E3I toluene tolerance APP7_1341 ENOG4107PE3 Mammalian cell entry related domain protein APP7_1342 ENOG4105CY3 ABC transporter, permease APP7_1343 ENOG4105DHJ ABC, transporter APP7_1344 ENOG4105C0H protease APP7_1345 ENOG4105ECP epimerase APP7_1351 ENOG4105EYM Major Facilitator superfamily APP7_1352 ENOG4105CMR udp-glucose 4-epimerase APP7_1357 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) APP7_1360 ENOG4105D2S major facilitator superfamily APP7_1361 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) APP7_1362 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase APP7_1363 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase APP7_1364 ENOG4107RK2 ADP-ribose diphosphatase NudE APP7_1365 ENOG4105VEJ Heat shock protein APP7_1367 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter APP7_1368 ENOG4105DBV ornithine carbamoyltransferase APP7_1369 ENOG4105C5B carbamate kinase APP7_1370 ENOG4105C5Y PTS System APP7_1371 ENOG4107T0D ABC, transporter APP7_1372 ENOG4106SMU thiamine transporter membrane protein APP7_1373 ENOG4105KZ7 phosphocarrier protein hpr APP7_1374 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) APP7_1375 ENOG4105C5Y PTS System APP7_1376 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) APP7_1377 ENOG4105C4R Atp-dependent dna helicase APP7_1378 ENOG4107RSS Hydrogenase accessory protein HypB APP7_1379 ENOG4105CQS hydrogenase expression formation protein HypD APP7_1380 ENOG4105C45 hydrogenase expression formation protein (HypE) APP7_1381 ENOG4105C8H hydrogenase maturation protein Hypf APP7_1382 ENOG4105E3S small subunit APP7_1383 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein APP7_1384 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit APP7_1385 ENOG4105DPX Hydrogenase, large subunit APP7_1386 ENOG4108USZ hydrogenase APP7_1387 ENOG4108WGS hydrogenase 2-specific chaperone APP7_1390 ENOG4108JA2 transcriptioN-repair coupling factor APP7_1391 ENOG4108JA2 transcriptioN-repair coupling factor APP7_1392 ENOG4105CD8 aminopeptidase N APP7_1393 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) APP7_1394 ENOG4107ZVW dihydroneopterin aldolase APP7_1395 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) APP7_1396 ENOG4105CRP Part of the ABC transporter FtsEX involved in APP7_1397 ENOG4105CAK Cell division ATP-binding protein ftsE APP7_1398 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) APP7_1399 ENOG4106H78 methyltransferase APP7_1400 ENOG4105XW2 UPF0263 protein APP7_1401 ENOG4107UWN reductase APP7_1403 ENOG4105DMR ABC, transporter APP7_1404 ENOG4105GBT ABC transporter APP7_1405 ENOG4106PMH Extracellular solute-binding protein family 3 APP7_1406 ENOG4105E5Z arginine transporter ATP-binding subunit APP7_1407 ENOG4108V1U phospholipid-binding protein APP7_1409 ENOG4105KDP XRE family APP7_1410 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) APP7_1411 ENOG4108BPE -transporting atpase APP7_1412 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) APP7_1413 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) APP7_1414 ENOG41082RQ UPF0102 protein APP7_1415 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) APP7_1416 ENOG4105W4M Transport-associated protein APP7_1418 ENOG4105DA4 cytochrome c-type biogenesis protein APP7_1420 ENOG4105X3C heme exporter protein APP7_1421 ENOG41060IM Heme exporter protein APP7_1422 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) APP7_1423 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) APP7_1424 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) APP7_1427 ENOG4107QSA Oxaloacetate decarboxylase APP7_1428 ENOG4105D9Q decarboxylase (Beta subunit) APP7_1429 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA APP7_1430 ENOG4105CA0 peroxidase APP7_1432 ENOG4108VIA integral membrane protein APP7_1433 ENOG41090ED Protein with unknown function (DUF469) APP7_1434 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) APP7_1435 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) APP7_1436 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) APP7_1438 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein APP7_1439 ENOG4106KVJ cytochrome C assembly protein APP7_1440 ENOG4108JU6 CBS domain protein APP7_1441 ENOG4105C8J )-transporter APP7_1442 ENOG4108EQA pts system APP7_1443 ENOG4105ETZ PTS System APP7_1444 ENOG4105F3R pts system mannose fructose sorbose family iid APP7_1445 ENOG4108NK4 UPF0266 membrane protein APP7_1446 ENOG4105EIP mannose-6-phosphate isomerase APP7_1448 ENOG4105C42 Type I secretion membrane fusion protein (HlyD APP7_1449 ENOG4108JJA ABC, transporter APP7_1450 ENOG4107V48 Hemolysin-type calcium-binding APP7_1451 ENOG4105C4Y ABC transporter APP7_1452 ENOG4107RCV ABC transporter, permease APP7_1453 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) APP7_1454 ENOG4105DFU Cell wall formation (By similarity) APP7_1457 ENOG4108JQ1 Dehydrogenase APP7_1458 ENOG4105E66 phosphoriboisomerase A APP7_1460 ENOG4105C7B Threonine dehydratase APP7_1461 ENOG4108YZY peptidylprolyl cis-trans isomerase APP7_1464 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) APP7_1466 ENOG4108R96 Methyltransferase, YaeB family APP7_1467 ENOG4105DFS Conserved Protein APP7_1468 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase APP7_1471 ENOG4105C1B dTDP-glucose 4-6-dehydratase APP7_1472 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) APP7_1474 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase APP7_1477 ENOG4107YYJ Glycosyl transferase, family 2 APP7_1479 ENOG4108KBE Glycosyl transferase, family 2 APP7_1480 ENOG4105D3Q Sugar transferase APP7_1481 ENOG4105VCC 30S ribosomal protein S21 APP7_1482 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) APP7_1483 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) APP7_1484 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) APP7_1486 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) APP7_1487 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen APP7_1488 ENOG4105EJ2 Transcriptional regulator APP7_1489 ENOG4105C5Q Transcriptional regulator APP7_1490 ENOG4105EHV domain protein APP7_1492 ENOG4105NXV High-affinity zinc uptake system protein APP7_1494 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase APP7_1496 ENOG4105C03 ribonuclease APP7_1498 ENOG4105IYK transposase APP7_1499 ENOG4105DQ6 Transposase APP7_1500 ENOG4105DQ6 Transposase APP7_1501 ENOG4105DYS nad(p)h dehydrogenase (quinone) APP7_1504 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) APP7_1505 ENOG4108BGM Quinol dehydrogenase periplasmic component APP7_1506 ENOG4105GXZ Ferredoxin-type protein NapH APP7_1507 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) APP7_1508 ENOG4105CUW cytochrome C-TYPE protein APP7_1510 ENOG4105KA0 thioesterase Superfamily protein APP7_1511 ENOG4105CQB FAD linked oxidase domain protein APP7_1513 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator APP7_1514 ENOG4105C2J ABC transporter APP7_1515 ENOG4108HWV )-transporter APP7_1520 ENOG4108IQE Amp-dependent synthetase and ligase APP7_1521 ENOG4107QM2 Aldo Keto reductase APP7_1522 ENOG4105KZW UPF0381 protein APP7_1523 ENOG4105CIC tryptophan-specific transport protein APP7_1525 ENOG4105D9M gamma-glutamylcysteine synthetase APP7_1527 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) APP7_1528 ENOG4107QTH restriction modification system DNA specificity domain APP7_1533 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein APP7_1534 ENOG4108UBT opacity-associated protein APP7_1536 ENOG4105XA0 heptosyltransferase ii APP7_1537 ENOG4105D16 lipopolysaccharide heptosyltransferase i APP7_1538 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) APP7_1539 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) APP7_1540 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) APP7_1541 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) APP7_1543 ENOG4108J1Q APP7_1546 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) APP7_1548 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase APP7_1549 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) APP7_1552 ENOG4105VUC UPF0237 protein APP7_1553 ENOG4105C2I pirin domain protein APP7_1554 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction APP7_1557 ENOG4105EM2 membrane APP7_1558 ENOG4108Z5K methylglyoxal synthase APP7_1559 ENOG4105D98 threonine synthase APP7_1560 ENOG4105IYK transposase APP7_1561 ENOG4105DQ6 Transposase APP7_1564 ENOG4107YB6 acetyltransferase, (GNAT) family APP7_1565 ENOG4105MYG DNA polymerase iii, chi subunit APP7_1566 ENOG4108WZM domain protein APP7_1568 ENOG4107YZP Rhodanese domain protein APP7_1570 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase APP7_1571 ENOG4105D7W serine acetyltransferase APP7_1572 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) APP7_1574 ENOG4107QX9 Thiol disulfide interChange protein APP7_1575 ENOG4108M1T Cytochrome c-type biogenesis protein APP7_1576 ENOG4108M1T Cytochrome c-type biogenesis protein APP7_1577 ENOG4108RIR Molybdenum cofactor biosynthesis protein APP7_1578 ENOG4108YZA Nitrogen regulatory protein pii APP7_1579 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) APP7_1581 ENOG410863D Flavinator of succinate dehydrogenase APP7_1583 ENOG4105D4P Coproporphyrinogen iii oxidase APP7_1584 ENOG4108K3A Glutathione S-transferase APP7_1585 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) APP7_1587 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) APP7_1588 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) APP7_1589 ENOG4105E33 succinate dehydrogenase APP7_1590 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) APP7_1591 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) APP7_1593 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter APP7_1601 ENOG4105D1U peptidase U62 modulator of DNA gyrase APP7_1604 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) APP7_1605 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family APP7_1606 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) APP7_1607 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) APP7_1609 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) APP7_1610 ENOG4105EGZ biosynthesis protein APP7_1611 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase APP7_1613 ENOG4108IJ1 Dehydrogenase APP7_1614 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase APP7_1616 ENOG4105ESV Glycosyl transferase, family 4 APP7_1619 ENOG4105CJR Integral membrane protein (MviN APP7_1620 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) APP7_1621 ENOG4105C1A potassium transporter peripheral membrane APP7_1622 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B APP7_1623 ENOG4105EM7 Selenocysteine-specific translation elongation factor APP7_1625 ENOG4105QTB Flavodoxin APP7_1626 ENOG4105CMG Carbohydrate kinase APP7_1629 ENOG4108MVK Receptor APP7_1631 ENOG4105M8F Biopolymer transport protein exbD tolR APP7_1634 ENOG4105DWU Membrane APP7_1635 ENOG4105DG4 malate L-lactate dehydrogenase APP7_1641 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase APP7_1643 ENOG4105F9F transposase APP7_1648 ENOG4105DKW ABC transporter APP7_1651 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein APP7_1652 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) APP7_1653 ENOG4108RR8 protoporphyrinogen oxidase APP7_1654 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) APP7_1655 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) APP7_1656 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) APP7_1658 ENOG4105DZ1 carboxypeptidase APP7_1660 ENOG4105CNI cell division protein FtsW APP7_1661 ENOG4105CJN penicillin-binding protein APP7_1662 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) APP7_1663 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) APP7_1665 ENOG4105CDA abc transporter atp-binding protein APP7_1666 ENOG4105E5Q amino acid AbC transporter APP7_1667 ENOG4105CEM UPF0597 protein APP7_1668 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) APP7_1669 ENOG410814C multidrug resistance protein APP7_1670 ENOG4105KZW UPF0381 protein APP7_1675 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) APP7_1676 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) APP7_1680 ENOG4108YZ9 Urea amidohydrolase subunit gamma APP7_1682 ENOG4108JJB ABC transporter APP7_1684 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein APP7_1685 ENOG4108A51 APP7_1686 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component APP7_1687 ENOG4108M0I Transcriptional regulator APP7_1689 ENOG4107QWE )-transporter APP7_1690 ENOG4105E61 Mannitol repressor protein APP7_1692 ENOG4105CTS PTS system mannitol-specific APP7_1693 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) APP7_1694 ENOG410804X Transcriptional regulator APP7_1699 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) APP7_1701 ENOG4105VRX Protein slyX homolog APP7_1702 ENOG4108V1T peptidylprolyl cis-trans isomerase APP7_1703 ENOG4105WWK YheO domain protein APP7_1704 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) APP7_1705 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) APP7_1708 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) APP7_1709 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) APP7_1711 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) APP7_1713 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) APP7_1718 ENOG410667J hydrolase APP7_1719 ENOG4105EAB amino acid AbC transporter APP7_1720 ENOG4105K5B UPF0225 protein APP7_1722 ENOG4105F3R pts system mannose fructose sorbose family iid APP7_1723 ENOG4105ETZ PTS System APP7_1724 ENOG4108EQA pts system APP7_1725 ENOG4105C6Z Gluconate APP7_1726 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family APP7_1727 ENOG4105DIQ Transcriptional regulator APP7_1728 ENOG4105ETE Transcriptional regulator (LacI family APP7_1731 ENOG4105CNN ABC, transporter APP7_1732 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator APP7_1733 ENOG4108RVA ribokinase APP7_1734 ENOG4107QY8 reductase APP7_1735 ENOG4105QAX Iron-sulfur APP7_1736 ENOG4107KGK dmso reductase anchor subunit APP7_1737 ENOG4108NEM leader-binding protein dmsD APP7_1738 ENOG4105N1P Ferredoxin-type protein APP7_1744 ENOG4107EDW L-fucose operon activator APP7_1745 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) APP7_1746 ENOG4105CMG Carbohydrate kinase APP7_1747 ENOG4105NWF RbsD or FucU transport APP7_1748 ENOG4107W7X Aldolase APP7_1749 ENOG4105EDR glucose galactose transporter APP7_1750 ENOG4105C0A alcohol dehydrogenase APP7_1751 ENOG4105R3P Inner membrane protein yagU APP7_1752 ENOG4105E5Q amino acid AbC transporter APP7_1754 ENOG4105CDA abc transporter atp-binding protein APP7_1755 ENOG4105CT1 (ABC) transporter APP7_1756 ENOG4105E12 capsule polysaccharide APP7_1764 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase APP7_1765 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase APP7_1766 ENOG4108V1T peptidylprolyl cis-trans isomerase APP7_1772 ENOG4105C79 DNA protecting protein DprA APP7_1773 ENOG4105EPD Oligopeptide transporter, Opt family APP7_1776 ENOG4105PM1 preprotein translocase subunit SecE APP7_1777 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) APP7_1778 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) APP7_1779 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) APP7_1780 ENOG4108VZM 50s ribosomal protein L10 APP7_1781 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) APP7_1788 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) APP7_1796 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) APP7_1797 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) APP7_1798 ENOG4105PW4 Sugar fermentation stimulation protein homolog APP7_1799 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase APP7_1800 ENOG4105CEN a g-specific adenine glycosylase APP7_1801 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) APP7_1802 ENOG4105E4C Lytic transglycosylase catalytic APP7_1808 ENOG4108JJA ABC, transporter APP7_1809 ENOG4108MBX Secretion Protein APP7_1810 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY APP7_1813 ENOG4105CGH 5'-nucleotidase APP7_1814 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family APP7_1815 ENOG4105YES addiction module antidote protein APP7_1816 ENOG4105C0P Mg chelatase subunit ChlI APP7_1818 ENOG41088T4 Helicase IV APP7_1824 ENOG4108ZHR arsR family transcriptional regulator APP7_1825 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the APP7_1832 ENOG4105C0P Mg chelatase subunit ChlI APP7_1833 ENOG4106IIQ Outer membrane lipoprotein APP7_1834 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) APP7_1837 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) APP7_1838 ENOG4105EVU fructokinase APP7_1839 ENOG4108MB0 N-acetylneuraminate lyase APP7_1840 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) APP7_1841 ENOG4105CE4 GlcNAc 6-P deacetylase APP7_1842 ENOG4105C9Q fumarate hydratase class II APP7_1845 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) APP7_1846 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) APP7_1847 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) APP7_1848 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity APP7_1849 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) APP7_1850 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) APP7_1851 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) APP7_1852 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) APP7_1853 ENOG41083MP 50s ribosomal protein l29 APP7_1854 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal APP7_1856 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) APP7_1857 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits APP7_1858 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) APP7_1859 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) APP7_1860 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) APP7_1861 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) APP7_1862 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) APP7_1863 ENOG4105VPB 50S ribosomal protein L30 APP7_1865 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) APP7_1867 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits APP7_1868 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) APP7_1869 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) APP7_1870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) APP7_1872 ENOG4105K5M 30s ribosomal protein S16 APP7_1873 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) APP7_1874 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) APP7_1875 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) APP7_1876 ENOG4105EZE Cupin 4 family protein APP7_1877 ENOG4105S10 periplasmic binding protein APP7_1878 ENOG4105EHG Permease protein APP7_1884 ENOG4108J2R molybdopterin oxidoreductase APP7_1887 ENOG4105WDY DNA (cytosine-5-)-methyltransferase APP7_1890 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) APP7_1893 ENOG4105WD1 Membrane APP7_1894 ENOG4105K64 Glycosyl transferase, family 2 APP7_1895 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) APP7_1896 ENOG4105RX8 Protein of unknown function (DUF1523) APP7_1897 ENOG4105F8V Hydrolase, tatD family APP7_1899 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) APP7_1900 ENOG4105DJY efflux transporter, rnd family, mfp subunit APP7_1901 ENOG4107ZJM MltA-interacting protein MipA APP7_1902 ENOG4107QRG dna polymerase iii APP7_1903 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) APP7_1904 ENOG4105HHA aminodeoxychorismate lyase APP7_1905 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) APP7_1906 ENOG4105DJV ribulose-phosphate 3-epimerase APP7_1907 ENOG4105NRA 50s ribosomal protein l31 type b APP7_1908 ENOG4105YK5 50S ribosomal protein L36 APP7_1909 ENOG4105BZ4 penicillin-binding protein APP7_1910 ENOG4108IPT Naphthoate synthase APP7_1911 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) APP7_1913 ENOG4105CB5 ATP-dependent DNA helicase recG APP7_1918 ENOG4108WQI RNA Polymerase APP7_1919 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) APP7_1920 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) APP7_1921 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) APP7_1922 ENOG4105CXY transporter APP7_1924 ENOG4105CU9 asparagine synthetase A APP7_1925 ENOG4108VVK transcriptional Regulator, AsnC APP7_1926 ENOG4108I5U Uridine phosphorylase APP7_1927 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) APP7_1930 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) APP7_1935 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein APP7_1936 ENOG4108I5D sulfate abc transporter APP7_1937 ENOG4105ECW sulfate abc transporter APP7_1938 ENOG4108IJ6 ABC transporter APP7_1939 ENOG4105DMF Dehydrogenase APP7_1940 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase APP7_1941 ENOG4105D4A Cell wall formation (By similarity) APP7_1943 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase APP7_1944 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase APP7_1945 ENOG4105H2K paraquat-inducible protein a APP7_1946 ENOG4108KS2 transglutaminase domain protein APP7_1948 ENOG410681U heavy metal transport detoxification protein APP7_1949 ENOG4107QW4 alcohol dehydrogenase APP7_1950 ENOG4105EMY transcriptional regulator APP7_1951 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) APP7_1952 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) APP7_1953 ENOG4108ST3 glycosyltransferase APP7_1954 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein APP7_1955 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase APP7_1957 ENOG4108Z33 Thiol disulfide Interchange Protein APP7_1958 ENOG41063M6 Cell Division Protein APP7_1958 ENOG41063M6 Cell Division Protein APP7_1959 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) APP7_1961 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) APP7_1962 ENOG4105KUZ arsenate reductase APP7_1964 ENOG4105EEI dihydropteroate synthase APP7_1965 ENOG4105EI2 Pseudouridine synthase APP7_1968 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase APP7_1970 ENOG4107QXK peptidase APP7_1971 ENOG4105DSY exodeoxyribonuclease V, gamma APP7_1976 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) APP7_1977 ENOG4105DAN ATP-dependent protease APP7_1978 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) APP7_1979 ENOG4105C31 Tryptophanyl-tRNA synthetase APP7_1983 ENOG4105HF0 Membrane APP7_1986 ENOG4105F0N pyrophosphate phospho-hydrolase APP7_1989 ENOG4105TMB Formate nitrite transporter APP7_1991 ENOG4105DQ6 Transposase APP7_1992 ENOG4105IYK transposase APP7_1996 ENOG4105CMG Carbohydrate kinase APP7_1997 ENOG4105C93 Xylose Isomerase APP7_1998 ENOG4105DFW ABC transporter APP7_1999 ENOG4105C2J ABC transporter APP7_2000 ENOG4108HWW ABC transporter APP7_2001 ENOG4105T16 Transcriptional regulator (AraC family) APP7_2002 ENOG4105C9K Endothelin-converting enzyme 1 APP7_2004 ENOG4108IA2 Sodium pantothenate symporter APP7_2005 ENOG4105RG0 Membrane APP7_2006 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) APP7_2007 ENOG410903C (LipO)protein APP7_2008 ENOG4105DSB aldose 1-epimerase APP7_2011 ENOG4107BJW polysaccharide deacetylase APP7_2012 ENOG4105CND Glycosyl transferase, family 2 APP7_2014 ENOG4105CP7 Triose-phosphate isomerase APP7_2015 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) APP7_2016 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) APP7_2017 ENOG4108UM1 dedA family APP7_2020 ENOG4108K5P (LipO)protein APP7_2021 ENOG4108R3E Dna-3-methyladenine glycosylase i APP7_2023 ENOG4108P2H Inner membrane protein YjiG APP7_2024 ENOG41074DU domain protein APP7_2026 ENOG4105VG0 50S ribosomal protein l34 APP7_2027 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) APP7_2028 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) APP7_2029 ENOG4105C5F glutamine synthetase APP7_2030 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) APP7_2031 ENOG41087AY ADP-Ribose pyrophosphatase APP7_2032 ENOG4108VY7 phosphate-starvation-inducible protein PsiE APP7_2033 ENOG4105W8Z 4'-phosphopantetheinyl transferase APP7_2037 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) APP7_2038 ENOG4107S2Z UPF0761 membrane protein APP7_2049 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) APP7_2050 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) APP7_2052 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain APP7_2053 ENOG4107RYR Transcriptional regulator, Crp Fnr family APP7_2054 ENOG4105YP7 UPF0270 protein APP7_2055 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) APP7_2057 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase APP7_2058 ENOG4105W5Q DNA repair protein (RadC APP7_2059 ENOG4105KDC 50s ribosomal protein l28 APP7_2060 ENOG4105W0E 50S ribosomal protein L33 APP7_2062 ENOG4108JPW Aminotransferase APP7_2063 ENOG4105DY8 decarboxylase APP7_2064 ENOG4105KSU Redox protein APP7_2065 ENOG41066VF YeeE YedE family protein APP7_2066 ENOG4108WFC UPF0438 protein yifE APP7_2068 ENOG4107QUT magnesium and cobalt transport protein CorA APP7_2069 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) APP7_2072 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) APP7_2073 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) APP7_2074 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) APP7_2075 ENOG4105D52 delta-aminolevulinic acid dehydratase APP7_2078 ENOG4105CWM branched-chain amino acid transport system II carrier protein APP7_2079 ENOG4105CHR reductase APP7_2080 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase APP7_2081 ENOG4105WPN DNA integration recombination invertion protein APP7_2082 ENOG4105EAH synthase APP7_2084 ENOG4108YYH Nadph-dependent fmn reductase APP7_2085 ENOG4105MGM doxx family APP7_2087 ENOG4105K46 50S ribosomal protein l27 APP7_2088 ENOG4105QYV Membrane APP7_2091 ENOG4105MJ2 Competence protein APP7_2094 ENOG4105KEG ribosomal-protein-alanine acetyltransferase APP7_2095 ENOG4105C1J atp-dependent rna helicase APP7_2097 ENOG4105DEF Extracellular solute-binding protein, family 5 APP7_2099 ENOG4106HK8 GPR1 FUN34 yaaH family protein APP7_2100 ENOG4105E0A ABC, transporter APP7_2101 ENOG4105J76 Periplasmic binding protein APP7_2102 ENOG4105S6R Iron-hydroxamate transporter permease subunit APP7_2107 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) APP7_2108 ENOG4105CIH Imidazole acetol-phosphate transaminase APP7_2112 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) APP7_2115 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase APP7_2116 ENOG4105EX9 Membrane APP7_2117 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) APP7_2119 ENOG4105WBN Transcriptional regulator (LacI family APP7_2121 ENOG4105D7K pfkb domain protein APP7_2122 ENOG4105CEI nitrite reductase APP7_2123 ENOG4105D60 lipoprotein releasing system transmembrane protein APP7_2124 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) APP7_2125 ENOG4105D60 lipoprotein releasing system transmembrane protein APP7_2126 ENOG4105C5I Dehydrogenase APP7_2128 ENOG41063JG Transcriptional regulator APP7_2129 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) APP7_A0002 ENOG4105F9F transposase APP7_B0004 ENOG4108R0M Aminoglycoside