locus-tag	class	description
APP7_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APP7_0002	COG0592	DNA-directed DNA polymerase activity
APP7_0005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APP7_0008	COG0616	signal peptide processing
APP7_0009	COG2001	Belongs to the MraZ family
APP7_0011	COG3116	cell division
APP7_0012	COG0768	penicillin binding
APP7_0013	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APP7_0014	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APP7_0016	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APP7_0017	COG0772	Belongs to the SEDS family
APP7_0020	COG1181	Belongs to the D-alanine--D-alanine ligase family
APP7_0022	COG0849	cell division
APP7_0023	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APP7_0025	COG0497	DNA recombination
APP7_0026	COG4172	Belongs to the ABC transporter superfamily
APP7_0027	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APP7_0028	COG0601	transmembrane transport
APP7_0034	COG0012	GTP binding
APP7_0035	COG2020	methyltransferase activity
APP7_0037	COG3133	Outer membrane lipoprotein
APP7_0038	COG3102	Protein conserved in bacteria
APP7_0039	COG0018	arginyl-trna synthetase
APP7_0042	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APP7_0043	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APP7_0045	COG0196	riboflavin kinase activity
APP7_0046	COG3172	ATPase kinase involved in NAD metabolism
APP7_0047	COG2129	metallophosphoesterase
APP7_0048	COG0745	RESPONSE REGULATOR receiver
APP7_0050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APP7_0051	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APP7_0054	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APP7_0056	COG1561	YicC-like family, N-terminal region
APP7_0057	COG0354	folic acid binding
APP7_0058	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APP7_0059	COG2197	response regulator
APP7_0061	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APP7_0063	COG0747	negative chemotaxis
APP7_0064	COG0747	negative chemotaxis
APP7_0065	COG0601	transmembrane transport
APP7_0066	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APP7_0067	COG0444	Belongs to the ABC transporter superfamily
APP7_0068	COG4608	Belongs to the ABC transporter superfamily
APP7_0071	COG0251	oxidation-reduction process
APP7_0072	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APP7_0073	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APP7_0074	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APP7_0075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APP7_0076	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APP7_0077	COG0848	biopolymer transport protein
APP7_0078	COG0811	peptide transport
APP7_0080	COG3118	belongs to the thioredoxin family
APP7_0081	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APP7_0081	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_0081	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APP7_0082	COG1461	Dihydroxyacetone kinase
APP7_0083	COG2376	Dihydroxyacetone kinase
APP7_0084	COG0492	ferredoxin-NADP+ reductase activity
APP7_0089	COG3030	protein affecting phage T7 exclusion by the F plasmid
APP7_0092	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
APP7_0097	COG3978	acetolactate synthase activity
APP7_0100	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APP7_0101	COG0437	4 iron, 4 sulfur cluster binding
APP7_0102	COG3301	Polysulphide reductase, NrfD
APP7_0104	COG5295	Hep Hag repeat protein
APP7_0104	COG5295	Hep Hag repeat protein
APP7_0104	COG5295	Hep Hag repeat protein
APP7_0107	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APP7_0108	COG1414	Transcriptional regulator
APP7_0109	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APP7_0110	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
APP7_0112	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APP7_0113	COG3068	Protein conserved in bacteria
APP7_0119	COG1278	Cold shock
APP7_0120	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
APP7_0121	COG0793	Belongs to the peptidase S41A family
APP7_0123	COG2989	Protein conserved in bacteria
APP7_0124	COG3108	Peptidase M15
APP7_0125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APP7_0128	COG0537	adenosine 5'-monophosphoramidase activity
APP7_0129	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP7_0130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP7_0132	COG1162	GTPase activity
APP7_0133	COG0583	DNA-binding transcription factor activity
APP7_0134	COG1011	Hydrolase
APP7_0135	COG0583	DNA-binding transcription factor activity
APP7_0137	COG0252	asparaginase activity
APP7_0139	COG5413	integral membrane protein
APP7_0142	COG3835	regulator
APP7_0143	COG2610	gluconate transmembrane transporter activity
APP7_0144	COG1929	Belongs to the glycerate kinase type-1 family
APP7_0145	COG1254	Belongs to the acylphosphatase family
APP7_0146	COG3593	DNA synthesis involved in DNA repair
APP7_0147	COG1611	Belongs to the LOG family
APP7_0148	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APP7_0150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP7_0151	COG0316	Belongs to the HesB IscA family
APP7_0151	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APP7_0152	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APP7_0153	COG1805	sodium ion transport
APP7_0154	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APP7_0155	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APP7_0156	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
APP7_0157	COG2871	sodium ion transport
APP7_0158	COG1477	protein flavinylation
APP7_0159	COG2991	Protein conserved in bacteria
APP7_0161	COG2814	Major facilitator Superfamily
APP7_0162	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APP7_0164	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APP7_0168	COG4657	Part of a membrane complex involved in electron transport
APP7_0169	COG4656	Part of a membrane complex involved in electron transport
APP7_0174	COG1560	Kdo2-lipid A biosynthetic process
APP7_0175	COG0402	S-adenosylhomocysteine deaminase activity
APP7_0176	COG4143	(ABC) transporter
APP7_0177	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APP7_0178	COG0617	tRNA 3'-terminal CCA addition
APP7_0179	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APP7_0181	COG2911	Protein conserved in bacteria
APP7_0183	COG0346	lactoylglutathione lyase activity
APP7_0184	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APP7_0186	COG1605	Chorismate mutase
APP7_0186	COG0287	Prephenate dehydrogenase
APP7_0187	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APP7_0188	COG0859	PFAM glycosyl transferase family 9
APP7_0189	COG0469	pyruvate kinase activity
APP7_0190	COG2062	phosphohistidine phosphatase, SixA
APP7_0191	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APP7_0192	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
APP7_0193	COG0733	neurotransmitter:sodium symporter activity
APP7_0194	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APP7_0195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APP7_0196	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APP7_0198	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APP7_0199	COG4972	Pilus assembly protein
APP7_0203	COG4796	Type ii and iii secretion system protein
APP7_0204	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APP7_0205	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APP7_0206	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APP7_0207	COG1280	lysine exporter protein (LysE YggA)
APP7_0208	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APP7_0210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APP7_0211	COG2801	Transposase and inactivated derivatives
APP7_0212	COG2963	transposase activity
APP7_0214	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APP7_0225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APP7_0226	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APP7_0230	COG1253	flavin adenine dinucleotide binding
APP7_0231	COG0564	pseudouridine synthase activity
APP7_0232	COG0588	phosphoglycerate mutase activity
APP7_0234	COG1678	Uncharacterized ACR, COG1678
APP7_0235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APP7_0237	COG0271	Belongs to the BolA IbaG family
APP7_0242	COG0494	nUDIX hydrolase
APP7_0243	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APP7_0245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APP7_0248	COG4771	TonB-dependent receptor
APP7_0248	COG1629	transport
APP7_0249	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APP7_0250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APP7_0251	COG0083	homoserine kinase activity
APP7_0252	COG0527	aspartate kinase activity
APP7_0252	COG0460	homoserine dehydrogenase
APP7_0253	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APP7_0254	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APP7_0255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APP7_0256	COG2195	Cleaves the N-terminal amino acid of tripeptides
APP7_0257	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APP7_0258	COG0194	GDP metabolic process
APP7_0259	COG1538	Outer membrane efflux protein
APP7_0260	COG2914	Belongs to the UPF0125 (RnfH) family
APP7_0261	COG2867	negative regulation of translational initiation
APP7_0262	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APP7_0263	COG4149	molybdate abc transporter
APP7_0264	COG0725	ABC transporter, periplasmic molybdate-binding protein
APP7_0265	COG0842	Transport permease protein
APP7_0266	COG1131	(ABC) transporter
APP7_0267	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APP7_0268	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APP7_0270	COG0251	oxidation-reduction process
APP7_0272	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APP7_0273	COG1121	(ABC) transporter
APP7_0275	COG2920	part of a sulfur-relay system
APP7_0276	COG0670	Belongs to the BI1 family
APP7_0277	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APP7_0280	COG0084	hydrolase, TatD family'
APP7_0281	COG0210	DNA helicase
APP7_0282	COG3842	ATPase activity
APP7_0283	COG1176	ABC-type spermidine putrescine transport system, permease component I
APP7_0284	COG1177	transmembrane transport
APP7_0286	COG2255	four-way junction helicase activity
APP7_0287	COG2255	four-way junction helicase activity
APP7_0289	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APP7_0295	COG0732	type I restriction modification DNA specificity domain
APP7_0299	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APP7_0301	COG1271	oxidase subunit
APP7_0302	COG1294	oxidase, subunit
APP7_0303	COG0824	Thioesterase
APP7_0304	COG0811	peptide transport
APP7_0305	COG0848	biopolymer transport protein
APP7_0306	COG3064	Membrane
APP7_0306	COG3064	Membrane
APP7_0307	COG0823	Involved in the tonB-independent uptake of proteins
APP7_0308	COG0823	Involved in the tonB-independent uptake of proteins
APP7_0311	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APP7_0312	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APP7_0315	COG0303	'Molybdopterin
APP7_0316	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APP7_0317	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APP7_0318	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APP7_0320	COG0564	pseudouridine synthase activity
APP7_0321	COG3023	N-Acetylmuramoyl-L-alanine amidase
APP7_0322	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APP7_0323	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APP7_0324	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APP7_0325	COG0626	cystathionine gamma-synthase activity
APP7_0326	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APP7_0329	COG1702	phosphate starvation-inducible protein PhoH
APP7_0331	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APP7_0332	COG0709	Synthesizes selenophosphate from selenide and ATP
APP7_0334	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP7_0338	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP7_0340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_0341	COG1137	ATPase activity
APP7_0342	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APP7_0344	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APP7_0345	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APP7_0347	COG1704	LemA family
APP7_0348	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP7_0348	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APP7_0348	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APP7_0349	COG1105	Belongs to the carbohydrate kinase PfkB family
APP7_0350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_0350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_0352	COG1523	belongs to the glycosyl hydrolase 13 family
APP7_0353	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APP7_0354	COG0297	glycogen (starch) synthase activity
APP7_0355	COG0058	SHG alpha-glucan phosphorylase activity
APP7_0360	COG1187	pseudouridine synthase activity
APP7_0361	COG2814	Major facilitator Superfamily
APP7_0363	COG0210	DNA helicase
APP7_0369	COG0640	Transcriptional regulator
APP7_0377	COG2814	Major facilitator Superfamily
APP7_0379	COG3381	protein complex oligomerization
APP7_0381	COG0791	NLP P60 protein
APP7_0382	COG2932	Transcriptional regulator
APP7_0383	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
APP7_0384	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APP7_0385	COG2990	Protein conserved in bacteria
APP7_0387	COG1643	Atp-dependent helicase
APP7_0388	COG2707	UPF0756 membrane protein
APP7_0390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APP7_0391	COG0534	Mate efflux family protein
APP7_0392	COG1074	ATP-dependent DNA helicase activity
APP7_0393	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APP7_0394	COG4535	Mg2 and Co2 transporter CorC
APP7_0396	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APP7_0397	COG2826	transposase and inactivated derivatives, IS30 family
APP7_0398	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APP7_0399	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APP7_0400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APP7_0401	COG2271	Major facilitator Superfamily
APP7_0402	COG0584	glycerophosphoryl diester phosphodiesterase
APP7_0403	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APP7_0404	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
APP7_0405	COG0247	lactate metabolic process
APP7_0411	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APP7_0411	COG0517	IMP dehydrogenase activity
APP7_0413	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
APP7_0414	COG0385	Bile acid
APP7_0415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_0416	COG0561	phosphatase activity
APP7_0418	COG1595	DNA-templated transcription, initiation
APP7_0419	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APP7_0421	COG0318	PFAM AMP-dependent synthetase and ligase
APP7_0422	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APP7_0424	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APP7_0425	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APP7_0426	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APP7_0426	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APP7_0429	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APP7_0432	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APP7_0433	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APP7_0436	COG0750	zinc metalloprotease
APP7_0437	COG0575	Belongs to the CDS family
APP7_0438	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APP7_0441	COG0671	phosphoesterase, PA-phosphatase related
APP7_0442	COG1534	Rna-binding protein
APP7_0443	COG0463	Glycosyl transferase, family 2
APP7_0444	COG1686	Belongs to the peptidase S11 family
APP7_0445	COG0859	PFAM glycosyl transferase family 9
APP7_0447	COG0328	RNA-DNA hybrid ribonuclease activity
APP7_0448	COG1286	toxin biosynthetic process
APP7_0449	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APP7_0451	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APP7_0452	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APP7_0454	COG0251	oxidation-reduction process
APP7_0456	COG0582	viral genome integration into host DNA
APP7_0467	COG3723	Recombinational DNA repair protein, rece pathway
APP7_0486	COG3179	chitinase
APP7_0491	COG0740	serine-type endopeptidase activity
APP7_0506	COG5645	(Lipo)protein
APP7_0509	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APP7_0511	COG1792	Involved in formation and maintenance of cell shape
APP7_0512	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APP7_0513	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APP7_0514	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APP7_0515	COG0121	glutamine amidotransferase
APP7_0516	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APP7_0517	COG2949	membrane
APP7_0519	COG2826	transposase and inactivated derivatives, IS30 family
APP7_0521	COG1556	Lactate utilization protein
APP7_0522	COG1139	Iron-sulfur cluster binding protein
APP7_0523	COG0247	lactate metabolic process
APP7_0524	COG1620	l-lactate permease
APP7_0525	COG2916	Histone family protein nucleoid-structuring protein H-NS
APP7_0526	COG1757	Na H antiporter
APP7_0527	COG1879	ABC-type sugar transport system periplasmic component
APP7_0528	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APP7_0530	COG2990	Protein conserved in bacteria
APP7_0531	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP7_0532	COG0567	Dehydrogenase, E1 component
APP7_0533	COG1121	(ABC) transporter
APP7_0534	COG0739	heme binding
APP7_0535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APP7_0536	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APP7_0538	COG0561	phosphatase activity
APP7_0539	COG3850	Histidine kinase
APP7_0541	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APP7_0543	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APP7_0544	COG2983	Belongs to the UPF0260 family
APP7_0545	COG4221	oxidoreductase activity
APP7_0550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APP7_0550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APP7_0552	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APP7_0554	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP7_0555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APP7_0560	COG0640	Transcriptional regulator
APP7_0562	COG0189	ligase activity
APP7_0563	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APP7_0564	COG0280	phosphate acetyltransferase
APP7_0564	COG0281	malic enzyme
APP7_0566	COG3683	transport system, periplasmic component
APP7_0567	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APP7_0568	COG1115	amino acid carrier protein
APP7_0569	COG1116	anion transmembrane transporter activity
APP7_0570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APP7_0571	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APP7_0572	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APP7_0573	COG2104	thiamine diphosphate biosynthetic process
APP7_0575	COG2022	thiamine diphosphate biosynthetic process
APP7_0576	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APP7_0577	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APP7_0578	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP7_0579	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APP7_0580	COG0351	phosphomethylpyrimidine kinase
APP7_0581	COG0351	phosphomethylpyrimidine kinase
APP7_0583	COG0481	GTPase activity
APP7_0584	COG0681	Belongs to the peptidase S26 family
APP7_0585	COG0571	ribonuclease III activity
APP7_0586	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APP7_0603	COG0433	COG0433 Predicted ATPase
APP7_0604	COG1840	ABC-type Fe3 transport system, periplasmic component
APP7_0609	COG4178	(ABC) transporter
APP7_0611	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APP7_0612	COG2194	sulfuric ester hydrolase activity
APP7_0613	COG0528	UMP kinase activity
APP7_0614	COG0233	cytoplasmic translational termination
APP7_0615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APP7_0618	COG0590	tRNA wobble adenosine to inosine editing
APP7_0619	COG0513	Belongs to the DEAD box helicase family
APP7_0620	COG4785	May be involved in cell division
APP7_0621	COG1185	polyribonucleotide nucleotidyltransferase activity
APP7_0622	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APP7_0624	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APP7_0627	COG3083	sulfuric ester hydrolase activity
APP7_0628	COG3082	Protein of unknown function (DUF1414)
APP7_0629	COG1309	transcriptional regulator
APP7_0630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_0631	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APP7_0632	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APP7_0635	COG3955	Domain of unknown function (DUF1919)
APP7_0636	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APP7_0639	COG0516	GMP reductase activity
APP7_0639	COG0517	IMP dehydrogenase activity
APP7_0640	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APP7_0641	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APP7_0642	COG0814	amino acid
APP7_0643	COG0814	amino acid
APP7_0645	COG3105	Protein conserved in bacteria
APP7_0646	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APP7_0651	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
APP7_0652	COG1823	symporter activity
APP7_0653	COG0778	Nitroreductase
APP7_0655	COG0072	phenylalanine-tRNA ligase activity
APP7_0656	COG0776	regulation of translation
APP7_0657	COG0791	NLP P60 protein
APP7_0658	COG2801	Transposase and inactivated derivatives
APP7_0659	COG2963	transposase activity
APP7_0660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APP7_0661	COG1940	carbohydrate kinase activity
APP7_0661	COG1846	Transcriptional regulator
APP7_0662	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APP7_0663	COG1522	sequence-specific DNA binding
APP7_0664	COG1674	ftsk spoiiie
APP7_0665	COG2321	neutral zinc metallopeptidase
APP7_0666	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APP7_0667	COG1214	PFAM Peptidase M22, glycoprotease
APP7_0668	COG1435	thymidine kinase activity
APP7_0669	COG3074	FtsZ-dependent cytokinesis
APP7_0670	COG1494	fructose-1,6-bisphosphatase
APP7_0671	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APP7_0672	COG0577	efflux transmembrane transporter activity
APP7_0672	COG1136	(ABC) transporter
APP7_0673	COG2205	protein histidine kinase activity
APP7_0674	COG0745	RESPONSE REGULATOR receiver
APP7_0675	COG3956	TIGRFAM MazG family protein
APP7_0677	COG0285	dihydrofolate synthase activity
APP7_0678	COG0779	Required for maturation of 30S ribosomal subunits
APP7_0679	COG0195	Participates in both transcription termination and antitermination
APP7_0680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APP7_0681	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APP7_0682	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APP7_0683	COG2951	lytic endotransglycosylase activity
APP7_0685	COG0857	belongs to the CobB CobQ family
APP7_0685	COG0280	phosphate acetyltransferase
APP7_0687	COG0737	Belongs to the 5'-nucleotidase family
APP7_0691	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APP7_0693	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APP7_0695	COG0589	response to stress
APP7_0697	COG2969	positive regulation of protein catabolic process
APP7_0698	COG0625	glutathione transferase activity
APP7_0699	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APP7_0701	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APP7_0702	COG1448	Aminotransferase
APP7_0703	COG0006	proline dipeptidase activity
APP7_0707	COG0556	nucleotide-excision repair
APP7_0708	COG2822	iron ion transport
APP7_0709	COG2837	iron assimilation
APP7_0711	COG0613	PHP domain protein
APP7_0713	COG2925	Exonuclease
APP7_0714	COG0038	chloride channel
APP7_0715	COG0017	Asparaginyl-tRNA synthetase
APP7_0716	COG1509	lysine 2,3-aminomutase activity
APP7_0718	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APP7_0719	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APP7_0720	COG2814	Major facilitator Superfamily
APP7_0721	COG0741	lytic transglycosylase activity
APP7_0722	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APP7_0723	COG0626	cystathionine gamma-synthase activity
APP7_0724	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APP7_0728	COG2363	Small membrane protein
APP7_0729	COG0277	FAD linked oxidase domain protein
APP7_0730	COG0243	molybdopterin cofactor binding
APP7_0731	COG3005	denitrification pathway
APP7_0733	COG0315	cyclic pyranopterin monophosphate synthase activity
APP7_0734	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APP7_0735	COG0314	molybdopterin synthase activity
APP7_0736	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APP7_0737	COG1444	tRNA N-acetyltransferase activity
APP7_0739	COG0583	DNA-binding transcription factor activity
APP7_0744	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APP7_0745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APP7_0748	COG1737	Transcriptional regulator
APP7_0749	COG2731	YhcH YjgK YiaL family protein
APP7_0750	COG0248	Ppx GppA phosphatase
APP7_0752	COG0527	aspartate kinase activity
APP7_0753	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APP7_0754	COG3100	YcgL domain-containing protein
APP7_0755	COG0305	Participates in initiation and elongation during chromosome replication
APP7_0756	COG4607	ABC-type enterochelin transport system periplasmic component
APP7_0757	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP7_0758	COG4605	iron ion homeostasis
APP7_0759	COG4604	ABC transporter, ATP-binding protein
APP7_0760	COG1392	Phosphate transport regulator
APP7_0761	COG0306	phosphate transporter
APP7_0762	COG4991	sh3 domain protein
APP7_0764	COG3945	hemerythrin HHE cation binding domain
APP7_0765	COG0343	queuine tRNA-ribosyltransferase activity
APP7_0768	COG1278	Cold shock
APP7_0769	COG0288	reversible hydration of carbon dioxide
APP7_0770	COG0028	Belongs to the TPP enzyme family
APP7_0771	COG0440	acetolactate synthase activity
APP7_0772	COG0312	modulator of DNA gyrase
APP7_0773	COG3028	Belongs to the UPF0307 family
APP7_0774	COG3094	Invasion gene expression up-regulator, SirB
APP7_0776	COG1811	Na channel or pump
APP7_0777	COG3787	Belongs to the UPF0306 family
APP7_0778	COG0023	Translation Initiation Factor
APP7_0779	COG0284	orotidine-5'-phosphate decarboxylase activity
APP7_0780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APP7_0781	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APP7_0782	COG0776	regulation of translation
APP7_0783	COG0539	negative regulation of cytoplasmic translation
APP7_0785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APP7_0786	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APP7_0787	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APP7_0789	COG1785	Belongs to the alkaline phosphatase family
APP7_0790	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
APP7_0792	COG3264	Mechanosensitive ion channel
APP7_0792	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APP7_0793	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APP7_0793	COG3264	Mechanosensitive ion channel
APP7_0794	COG0318	PFAM AMP-dependent synthetase and ligase
APP7_0795	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APP7_0796	COG0596	Alpha beta hydrolase
APP7_0798	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APP7_0802	COG1380	Effector of murein hydrolase LrgA
APP7_0803	COG1346	cytolysis
APP7_0804	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APP7_0805	COG0582	viral genome integration into host DNA
APP7_0815	COG4626	Terminase
APP7_0815	COG1802	Transcriptional regulator
APP7_0823	COG2226	methyltransferase
APP7_0827	COG2333	competence protein COMEC
APP7_0827	COG0658	competence protein
APP7_0828	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APP7_0829	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APP7_0830	COG0737	Belongs to the 5'-nucleotidase family
APP7_0832	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APP7_0833	COG0508	dehydrogenase complex catalyzes the overall conversion of
APP7_0834	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APP7_0836	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APP7_0839	COG1132	(ABC) transporter
APP7_0840	COG1346	cytolysis
APP7_0842	COG1199	ATP-dependent helicase activity
APP7_0844	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APP7_0845	COG0629	single-stranded DNA binding
APP7_0850	COG2070	2-Nitropropane dioxygenase
APP7_0852	COG2315	Protein conserved in bacteria
APP7_0853	COG4172	Belongs to the ABC transporter superfamily
APP7_0854	COG4171	peptide transport system, permease
APP7_0855	COG4168	peptide transport system, permease
APP7_0856	COG4166	transmembrane transport
APP7_0857	COG3283	Transcriptional regulator of aromatic amino acids metabolism
APP7_0858	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APP7_0860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
APP7_0863	COG1368	sulfuric ester hydrolase activity
APP7_0864	COG0633	Ferredoxin
APP7_0864	COG3217	Mosc domain protein beta barrel domain protein
APP7_0865	COG1722	exodeoxyribonuclease VII activity
APP7_0866	COG0142	geranyltranstransferase activity
APP7_0869	COG1530	ribonuclease E activity
APP7_0870	COG1944	ATP diphosphatase activity
APP7_0873	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APP7_0875	COG2351	hydroxyisourate hydrolase activity
APP7_0876	COG1609	Transcriptional regulator
APP7_0877	COG0586	Pfam SNARE associated Golgi protein
APP7_0878	COG0187	DNA topoisomerase II activity
APP7_0879	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APP7_0880	COG1349	DNA-binding transcription factor activity
APP7_0881	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APP7_0882	COG2915	High frequency lysogenization protein hflD homolog
APP7_0883	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APP7_0884	COG4988	ABC transporter
APP7_0885	COG2911	Protein conserved in bacteria
APP7_0886	COG0729	surface antigen
APP7_0887	COG2861	carbohydrate metabolic process
APP7_0888	COG4942	peptidase
APP7_0889	COG0588	phosphoglycerate mutase activity
APP7_0891	COG0572	uridine kinase
APP7_0892	COG0717	Belongs to the dCTP deaminase family
APP7_0893	COG1309	transcriptional regulator
APP7_0894	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_0895	COG1129	ABC transporter
APP7_0895	COG0842	Transport permease protein
APP7_0896	COG0842	Transport permease protein
APP7_0898	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APP7_0899	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APP7_0900	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APP7_0902	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APP7_0903	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APP7_0904	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APP7_0905	COG4166	transmembrane transport
APP7_0906	COG0601	transmembrane transport
APP7_0908	COG0444	Belongs to the ABC transporter superfamily
APP7_0909	COG4608	Belongs to the ABC transporter superfamily
APP7_0911	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APP7_0913	COG0747	negative chemotaxis
APP7_0914	COG0814	amino acid
APP7_0915	COG1760	l-serine dehydratase
APP7_0917	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APP7_0917	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APP7_0918	COG0135	phosphoribosylanthranilate isomerase activity
APP7_0918	COG0134	indole-3-glycerol-phosphate synthase activity
APP7_0919	COG3177	Filamentation induced by cAMP protein fic
APP7_0920	COG3098	single-species biofilm formation
APP7_0921	COG0564	pseudouridine synthase activity
APP7_0922	COG3140	Belongs to the UPF0181 family
APP7_0924	COG3025	triphosphatase activity
APP7_0925	COG3106	COG3106 Predicted ATPase
APP7_0926	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APP7_0928	COG1473	amidohydrolase
APP7_0929	COG3069	C4-dicarboxylate transmembrane transporter activity
APP7_0932	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
APP7_0933	COG1466	dna polymerase III delta subunit
APP7_0934	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APP7_0935	COG0237	dephospho-CoA kinase activity
APP7_0937	COG1459	type II secretion system
APP7_0938	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APP7_0939	COG4969	Belongs to the N-Me-Phe pilin family
APP7_0940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APP7_0942	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APP7_0943	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APP7_0944	COG0730	response to heat
APP7_0945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APP7_0947	COG1024	Enoyl-CoA hydratase
APP7_0947	COG1250	3-hydroxyacyl-CoA dehydrogenase
APP7_0950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APP7_0951	COG3383	formate dehydrogenase (NAD+) activity
APP7_0951	COG0243	molybdopterin cofactor binding
APP7_0952	COG0243	molybdopterin cofactor binding
APP7_0952	COG3383	formate dehydrogenase (NAD+) activity
APP7_0953	COG0437	4 iron, 4 sulfur cluster binding
APP7_0954	COG2864	formate dehydrogenase
APP7_0955	COG3058	Necessary for formate dehydrogenase activity
APP7_0959	COG1560	Kdo2-lipid A biosynthetic process
APP7_0960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APP7_0962	COG0302	gtp cyclohydrolase
APP7_0963	COG3642	lipopolysaccharide core region biosynthetic process
APP7_0965	COG0110	maltose O-acetyltransferase activity
APP7_0968	COG0583	DNA-binding transcription factor activity
APP7_0972	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APP7_0974	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APP7_0975	COG0617	tRNA 3'-terminal CCA addition
APP7_0976	COG2963	transposase activity
APP7_0977	COG2801	Transposase and inactivated derivatives
APP7_0981	COG2975	iron-sulfur cluster assembly
APP7_0982	COG0633	Ferredoxin
APP7_0986	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APP7_0988	COG0822	iron-sulfur transferase activity
APP7_0989	COG1104	cysteine desulfurase activity
APP7_0990	COG1959	2 iron, 2 sulfur cluster binding
APP7_0992	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APP7_0993	COG0784	Response regulator, receiver
APP7_0993	COG5002	protein histidine kinase activity
APP7_0993	COG2198	Histidine kinase
APP7_0994	COG0697	spore germination
APP7_0995	COG2840	Smr protein MutS2
APP7_0996	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APP7_0997	COG2226	methyltransferase
APP7_0998	COG2830	Protein of unknown function (DUF452)
APP7_0999	COG0156	8-amino-7-oxononanoate synthase activity
APP7_1000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APP7_1002	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APP7_1003	COG2027	D-alanyl-D-alanine carboxypeptidase
APP7_1006	COG2801	Transposase and inactivated derivatives
APP7_1010	COG1444	tRNA N-acetyltransferase activity
APP7_1011	COG0138	bifunctional purine biosynthesis protein purh
APP7_1012	COG2801	Transposase and inactivated derivatives
APP7_1014	COG3210	domain, Protein
APP7_1015	COG2831	hemolysin activation secretion protein
APP7_1016	COG2831	hemolysin activation secretion protein
APP7_1018	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APP7_1022	COG0786	glutamate:sodium symporter activity
APP7_1025	COG2350	Protein conserved in bacteria
APP7_1026	COG1607	acyl-coa hydrolase
APP7_1029	COG3092	negative regulation of chromosome organization
APP7_1032	COG2056	Na+-H+ antiporter family
APP7_1033	COG0708	Exodeoxyribonuclease III
APP7_1034	COG0583	DNA-binding transcription factor activity
APP7_1038	COG0254	rRNA binding
APP7_1041	COG0753	catalase activity
APP7_1042	COG2963	transposase activity
APP7_1043	COG2801	Transposase and inactivated derivatives
APP7_1044	COG1408	metallophosphoesterase
APP7_1045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP7_1046	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APP7_1047	COG1085	galactose-1-phosphate uridylyltransferase
APP7_1049	COG2017	converts alpha-aldose to the beta-anomer
APP7_1054	COG2826	transposase and inactivated derivatives, IS30 family
APP7_1057	COG0489	protein tyrosine kinase activity
APP7_1059	COG2095	MarC family integral membrane protein
APP7_1060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APP7_1062	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APP7_1063	COG2354	Protein conserved in bacteria
APP7_1064	COG3071	HemY protein
APP7_1065	COG2959	enzyme of heme biosynthesis
APP7_1067	COG0181	hydroxymethylbilane synthase activity
APP7_1068	COG1454	alcohol dehydrogenase
APP7_1068	COG1012	belongs to the aldehyde dehydrogenase family
APP7_1071	COG0813	purine-nucleoside phosphorylase activity
APP7_1073	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APP7_1074	COG2364	Membrane
APP7_1075	COG0800	Aldolase
APP7_1076	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP7_1077	COG1904	glucuronate isomerase
APP7_1079	COG2186	Transcriptional regulator
APP7_1080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APP7_1080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APP7_1081	COG1216	Glycosyl transferase, family 2
APP7_1082	COG1216	Glycosyl transferase, family 2
APP7_1084	COG3306	glycosyltransferase involved in LPS biosynthesis
APP7_1086	COG5039	Polysaccharide pyruvyl transferase
APP7_1087	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APP7_1088	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APP7_1089	COG0077	Prephenate dehydratase
APP7_1089	COG1605	Chorismate mutase
APP7_1090	COG0339	signal peptide processing
APP7_1091	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APP7_1092	COG1882	Formate acetyltransferase
APP7_1093	COG2116	formate transmembrane transporter activity
APP7_1094	COG1238	metal cluster binding
APP7_1095	COG0501	Belongs to the peptidase M48B family
APP7_1097	COG2431	L-lysine efflux transmembrane transporter activity
APP7_1098	COG1169	isochorismate synthase
APP7_1099	COG0436	Aminotransferase
APP7_1101	COG2962	Rard protein
APP7_1102	COG1280	lysine exporter protein (LysE YggA)
APP7_1103	COG1629	transport
APP7_1103	COG4771	TonB-dependent receptor
APP7_1104	COG0748	coenzyme F420 binding
APP7_1106	COG4235	cytochrome complex assembly
APP7_1106	COG3088	subunit of a heme lyase
APP7_1107	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP7_1108	COG1138	Cytochrome C-type biogenesis protein
APP7_1109	COG0475	glutathione-regulated potassium exporter activity
APP7_1109	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APP7_1110	COG0475	glutathione-regulated potassium exporter activity
APP7_1110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APP7_1112	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APP7_1113	COG2963	transposase activity
APP7_1114	COG2963	transposase activity
APP7_1115	COG2801	Transposase and inactivated derivatives
APP7_1116	COG2801	Transposase and inactivated derivatives
APP7_1117	COG3111	PFAM Bacterial OB fold (BOF) protein
APP7_1121	COG0745	RESPONSE REGULATOR receiver
APP7_1122	COG0642	Histidine kinase
APP7_1123	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APP7_1124	COG1862	Preprotein translocase
APP7_1125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APP7_1126	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APP7_1127	COG1528	Iron-storage protein
APP7_1128	COG1528	Iron-storage protein
APP7_1129	COG2252	PERMEase
APP7_1130	COG0424	maF-like protein
APP7_1132	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP7_1132	COG0301	tRNA thio-modification
APP7_1134	COG0330	HflC and HflK could
APP7_1135	COG0330	HflC and HflK could
APP7_1136	COG3118	belongs to the thioredoxin family
APP7_1140	COG0531	amino acid
APP7_1141	COG0531	amino acid
APP7_1144	COG3047	cAMP biosynthetic process
APP7_1145	COG0542	response to heat
APP7_1146	COG0798	PFAM Bile acid sodium symporter
APP7_1147	COG1393	Belongs to the ArsC family
APP7_1149	COG1027	Aspartate ammonia-lyase
APP7_1151	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APP7_1152	COG3583	domain protein
APP7_1152	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APP7_1152	COG3064	Membrane
APP7_1154	COG0720	synthase
APP7_1155	COG0602	queuosine metabolic process
APP7_1159	COG0795	lipopolysaccharide-transporting ATPase activity
APP7_1160	COG0795	lipopolysaccharide-transporting ATPase activity
APP7_1162	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APP7_1163	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APP7_1167	COG0861	Integral membrane protein TerC family
APP7_1168	COG1472	Belongs to the glycosyl hydrolase 3 family
APP7_1169	COG2826	transposase and inactivated derivatives, IS30 family
APP7_1171	COG0148	phosphopyruvate hydratase activity
APP7_1172	COG1051	belongs to the nudix hydrolase family
APP7_1173	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
APP7_1178	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APP7_1179	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APP7_1180	COG0564	pseudouridine synthase activity
APP7_1182	COG0205	6-phosphofructokinase activity
APP7_1183	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APP7_1184	COG1525	nuclease
APP7_1185	COG1115	amino acid carrier protein
APP7_1186	COG0628	permease
APP7_1189	COG3307	-O-antigen
APP7_1190	COG1519	Transferase
APP7_1192	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APP7_1193	COG0802	atpase or kinase
APP7_1194	COG1388	LysM domain
APP7_1194	COG0860	N-Acetylmuramoyl-L-alanine amidase
APP7_1195	COG0166	Belongs to the GPI family
APP7_1196	COG2960	long-chain fatty acid transporting porin activity
APP7_1197	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APP7_1201	COG2137	regulation of response to DNA damage stimulus
APP7_1202	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APP7_1203	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APP7_1205	COG1322	Protein conserved in bacteria
APP7_1206	COG0512	Glutamine amidotransferase of anthranilate synthase
APP7_1209	COG0494	nUDIX hydrolase
APP7_1210	COG0217	transcriptional regulatory protein
APP7_1212	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APP7_1213	COG0612	Peptidase, M16
APP7_1215	COG0471	metal ion transport
APP7_1216	COG0583	DNA-binding transcription factor activity
APP7_1217	COG3266	domain, Protein
APP7_1218	COG1187	pseudouridine synthase activity
APP7_1219	COG0009	L-threonylcarbamoyladenylate synthase
APP7_1220	COG2837	iron assimilation
APP7_1221	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APP7_1222	COG0512	Glutamine amidotransferase of anthranilate synthase
APP7_1224	COG2226	methyltransferase
APP7_1225	COG2268	Band 7 protein
APP7_1226	COG2841	Protein conserved in bacteria
APP7_1229	COG2965	DNA replication, synthesis of RNA primer
APP7_1232	COG3201	nicotinamide mononucleotide transporter
APP7_1233	COG2976	Protein conserved in bacteria
APP7_1235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APP7_1236	COG1426	Protein conserved in bacteria
APP7_1237	COG0659	secondary active sulfate transmembrane transporter activity
APP7_1239	COG0673	inositol 2-dehydrogenase activity
APP7_1240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APP7_1240	COG0475	glutathione-regulated potassium exporter activity
APP7_1246	COG2207	Transcriptional regulator
APP7_1248	COG1902	pentaerythritol trinitrate reductase activity
APP7_1249	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APP7_1251	COG2084	Dehydrogenase
APP7_1252	COG0778	Nitroreductase
APP7_1253	COG2095	MarC family integral membrane protein
APP7_1256	COG0625	glutathione transferase activity
APP7_1259	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APP7_1260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APP7_1263	COG1275	C4-dicarboxylate transporter malic acid transport protein
APP7_1264	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APP7_1266	COG1132	(ABC) transporter
APP7_1267	COG1854	S-ribosylhomocysteine lyase activity
APP7_1268	COG3008	intermembrane lipid transfer
APP7_1269	COG0735	belongs to the Fur family
APP7_1270	COG0716	FMN binding
APP7_1272	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APP7_1273	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APP7_1274	COG2252	PERMEase
APP7_1275	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APP7_1276	COG2081	HI0933 family
APP7_1277	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APP7_1279	COG0560	Phosphoserine phosphatase
APP7_1282	COG0058	SHG alpha-glucan phosphorylase activity
APP7_1283	COG2909	trisaccharide binding
APP7_1285	COG4580	involved in the transport of maltose and maltodextrins
APP7_1286	COG3842	ATPase activity
APP7_1289	COG3833	ABC-type maltose transport systems, permease component
APP7_1290	COG1640	4-alpha-glucanotransferase
APP7_1291	COG1966	Carbon starvation protein
APP7_1292	COG0084	hydrolase, TatD family'
APP7_1293	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APP7_1295	COG0778	Nitroreductase
APP7_1298	COG4172	Belongs to the ABC transporter superfamily
APP7_1299	COG0191	fructose-bisphosphate aldolase activity
APP7_1300	COG0126	phosphoglycerate kinase activity
APP7_1301	COG0471	metal ion transport
APP7_1302	COG0471	metal ion transport
APP7_1303	COG0471	metal ion transport
APP7_1304	COG0187	DNA topoisomerase II activity
APP7_1305	COG5002	protein histidine kinase activity
APP7_1306	COG0745	RESPONSE REGULATOR receiver
APP7_1312	COG0789	Transcriptional regulator
APP7_1316	COG0300	oxidoreductase activity
APP7_1317	COG0778	Nitroreductase
APP7_1318	COG0616	signal peptide processing
APP7_1319	COG3719	Belongs to the RNase T2 family
APP7_1321	COG1252	NADH dehydrogenase
APP7_1322	COG2183	response to ionizing radiation
APP7_1323	COG3063	Type IV pilus biogenesis stability protein PilW
APP7_1324	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APP7_1327	COG2835	tetraacyldisaccharide 4'-kinase activity
APP7_1329	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APP7_1331	COG2166	iron-sulfur cluster assembly
APP7_1332	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APP7_1333	COG0488	(ABC) transporter
APP7_1334	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APP7_1338	COG5007	Belongs to the BolA IbaG family
APP7_1340	COG2854	intermembrane phospholipid transfer
APP7_1341	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APP7_1342	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APP7_1343	COG1127	ABC transporter
APP7_1344	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APP7_1345	COG1090	epimerase
APP7_1351	COG2814	Major facilitator Superfamily
APP7_1357	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APP7_1359	COG1794	racemase activity, acting on amino acids and derivatives
APP7_1360	COG2814	Major facilitator Superfamily
APP7_1361	COG0363	glucosamine-6-phosphate deaminase activity
APP7_1362	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APP7_1363	COG1218	3'(2'),5'-bisphosphate nucleotidase
APP7_1364	COG0494	nUDIX hydrolase
APP7_1365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APP7_1367	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APP7_1368	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APP7_1369	COG0549	Belongs to the carbamate kinase family
APP7_1371	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APP7_1372	COG1178	ABC-type Fe3 transport system permease component
APP7_1373	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_1374	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APP7_1375	COG2190	(PTS) system
APP7_1376	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APP7_1377	COG0210	DNA helicase
APP7_1378	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APP7_1379	COG0409	Hydrogenase expression formation protein
APP7_1380	COG0309	Hydrogenase expression formation protein (HypE)
APP7_1381	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APP7_1382	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APP7_1383	COG0437	4 iron, 4 sulfur cluster binding
APP7_1384	COG5557	Pfam Polysulphide reductase, NrfD
APP7_1385	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APP7_1386	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APP7_1387	COG1773	rubredoxin
APP7_1388	COG0298	carbon dioxide binding
APP7_1389	COG0375	protein maturation
APP7_1390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APP7_1391	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APP7_1392	COG0308	aminopeptidase N
APP7_1393	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APP7_1394	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APP7_1395	COG0295	cytidine deaminase activity
APP7_1396	COG2177	Part of the ABC transporter FtsEX involved in
APP7_1397	COG2884	Cell division ATP-binding protein ftsE
APP7_1398	COG0552	protein localization to endoplasmic reticulum
APP7_1399	COG0742	ribosomal rna small subunit methyltransferase
APP7_1400	COG3099	Belongs to the UPF0263 family
APP7_1401	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APP7_1403	COG4160	amino acid transport
APP7_1404	COG4215	(ABC) transporter
APP7_1405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APP7_1406	COG1126	abc transporter atp-binding protein
APP7_1407	COG1881	PFAM PEBP family protein
APP7_1409	COG3620	sequence-specific DNA binding
APP7_1410	COG4232	protein-disulfide reductase activity
APP7_1411	COG3101	peptidyl-lysine hydroxylation
APP7_1413	COG3107	peptidoglycan biosynthetic process
APP7_1414	COG0792	nuclease activity
APP7_1415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APP7_1418	COG1138	Cytochrome C-type biogenesis protein
APP7_1420	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP7_1421	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP7_1422	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APP7_1423	COG4133	protoheme IX ABC transporter activity
APP7_1424	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APP7_1426	COG3630	sodium ion export across plasma membrane
APP7_1428	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
APP7_1429	COG2824	Alkylphosphonate utilization operon protein PhnA
APP7_1430	COG1858	cytochrome C peroxidase
APP7_1432	COG0762	integral membrane protein
APP7_1433	COG3171	Protein conserved in bacteria
APP7_1434	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APP7_1435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APP7_1436	COG0416	fatty acid biosynthetic process
APP7_1438	COG1399	metal-binding, possibly nucleic acid-binding protein
APP7_1439	COG4137	Cytochrome C assembly protein
APP7_1440	COG4536	flavin adenine dinucleotide binding
APP7_1441	COG0733	neurotransmitter:sodium symporter activity
APP7_1442	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP7_1442	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_1443	COG3715	PTS system
APP7_1444	COG3716	PTS system mannose fructose sorbose family IID component
APP7_1451	COG1840	ABC-type Fe3 transport system, periplasmic component
APP7_1454	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APP7_1457	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APP7_1458	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APP7_1464	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APP7_1466	COG1720	tRNA m6t6A37 methyltransferase activity
APP7_1467	COG4804	nuclease activity
APP7_1468	COG1575	Belongs to the MenA family. Type 1 subfamily
APP7_1470	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APP7_1471	COG1088	dTDP-glucose 4,6-dehydratase activity
APP7_1476	COG1215	transferase activity, transferring glycosyl groups
APP7_1480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APP7_1481	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APP7_1483	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APP7_1484	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APP7_1486	COG0557	exoribonuclease II activity
APP7_1487	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP7_1488	COG1309	transcriptional regulator
APP7_1489	COG0583	DNA-binding transcription factor activity
APP7_1490	COG0678	peroxiredoxin activity
APP7_1490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APP7_1492	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APP7_1494	COG1755	Isoprenylcysteine carboxyl methyltransferase
APP7_1496	COG1530	ribonuclease E activity
APP7_1498	COG2963	transposase activity
APP7_1499	COG2801	Transposase and inactivated derivatives
APP7_1500	COG2801	Transposase and inactivated derivatives
APP7_1501	COG2249	NAD(P)H dehydrogenase (quinone) activity
APP7_1502	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APP7_1504	COG0243	molybdopterin cofactor binding
APP7_1505	COG0437	4 iron, 4 sulfur cluster binding
APP7_1506	COG0348	domain, Protein
APP7_1507	COG3043	anaerobic respiration
APP7_1508	COG3005	denitrification pathway
APP7_1510	COG2050	protein possibly involved in aromatic compounds catabolism
APP7_1511	COG0277	FAD linked oxidase domain protein
APP7_1511	COG0247	lactate metabolic process
APP7_1513	COG1879	ABC-type sugar transport system periplasmic component
APP7_1514	COG1129	ABC transporter
APP7_1515	COG4211	Belongs to the binding-protein-dependent transport system permease family
APP7_1520	COG1022	Amp-dependent synthetase and ligase
APP7_1521	COG4989	oxidoreductase activity
APP7_1522	COG3691	Protein conserved in bacteria
APP7_1523	COG0814	amino acid
APP7_1525	COG1181	Belongs to the D-alanine--D-alanine ligase family
APP7_1525	COG2918	glutathione biosynthetic process
APP7_1527	COG4974	Belongs to the 'phage' integrase family
APP7_1528	COG0732	type I restriction modification DNA specificity domain
APP7_1533	COG1555	photosystem II stabilization
APP7_1534	COG3266	domain, Protein
APP7_1534	COG3061	Opacity-associated protein A
APP7_1536	COG0859	PFAM glycosyl transferase family 9
APP7_1537	COG0859	PFAM glycosyl transferase family 9
APP7_1538	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APP7_1539	COG0049	tRNA binding
APP7_1540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APP7_1541	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APP7_1543	COG2801	Transposase and inactivated derivatives
APP7_1546	COG0825	malonyl-CoA metabolic process
APP7_1548	COG0204	Acyl-transferase
APP7_1549	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APP7_1554	COG0783	Belongs to the Dps family
APP7_1557	COG1289	transmembrane transporter activity
APP7_1558	COG1803	Methylglyoxal synthase
APP7_1559	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APP7_1560	COG2963	transposase activity
APP7_1561	COG2801	Transposase and inactivated derivatives
APP7_1564	COG2153	protein acetylation
APP7_1565	COG2927	DNA polymerase III (CHI subunit)
APP7_1566	COG1652	LysM domain
APP7_1568	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APP7_1570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APP7_1571	COG1045	serine acetyltransferase
APP7_1572	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APP7_1574	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APP7_1577	COG0521	Mo-molybdopterin cofactor biosynthetic process
APP7_1579	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APP7_1581	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APP7_1584	COG0625	glutathione transferase activity
APP7_1585	COG0019	diaminopimelate decarboxylase activity
APP7_1587	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APP7_1588	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
APP7_1589	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APP7_1590	COG1053	succinate dehydrogenase
APP7_1591	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
APP7_1593	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APP7_1594	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APP7_1604	COG4974	Belongs to the 'phage' integrase family
APP7_1605	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APP7_1609	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APP7_1610	COG2244	polysaccharide biosynthetic process
APP7_1611	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APP7_1613	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APP7_1614	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APP7_1615	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APP7_1619	COG0728	peptidoglycan biosynthetic process
APP7_1620	COG0268	Binds directly to 16S ribosomal RNA
APP7_1621	COG0569	domain protein
APP7_1622	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APP7_1623	COG3276	selenocysteine insertion sequence binding
APP7_1625	COG0716	FMN binding
APP7_1629	COG4771	TonB-dependent receptor
APP7_1629	COG1629	transport
APP7_1634	COG2431	L-lysine efflux transmembrane transporter activity
APP7_1635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APP7_1641	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APP7_1643	COG2826	transposase and inactivated derivatives, IS30 family
APP7_1648	COG1119	ATPase activity
APP7_1651	COG1739	Uncharacterized protein family UPF0029
APP7_1652	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APP7_1653	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APP7_1654	COG1970	mechanosensitive ion channel activity
APP7_1655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APP7_1656	COG0321	lipoyl(octanoyl) transferase activity
APP7_1657	COG2921	Belongs to the UPF0250 family
APP7_1658	COG1686	Belongs to the peptidase S11 family
APP7_1659	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APP7_1660	COG0772	Belongs to the SEDS family
APP7_1661	COG0768	penicillin binding
APP7_1662	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APP7_1663	COG0799	negative regulation of ribosome biogenesis
APP7_1665	COG1126	abc transporter atp-binding protein
APP7_1666	COG0765	amino acid transport
APP7_1667	COG3681	Belongs to the UPF0597 family
APP7_1668	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
APP7_1670	COG3691	Protein conserved in bacteria
APP7_1680	COG0831	urea catabolic process
APP7_1682	COG1122	ATPase activity
APP7_1683	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APP7_1684	COG0310	cobalt ion transport
APP7_1685	COG0310	cobalt ion transport
APP7_1686	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
APP7_1687	COG0583	DNA-binding transcription factor activity
APP7_1689	COG0490	domain, Protein
APP7_1689	COG0471	metal ion transport
APP7_1690	COG3722	fumarate hydratase activity
APP7_1693	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APP7_1694	COG1349	DNA-binding transcription factor activity
APP7_1699	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APP7_1700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APP7_1701	COG2900	Belongs to the SlyX family
APP7_1702	COG0545	Peptidyl-prolyl cis-trans isomerase
APP7_1703	COG2964	Protein conserved in bacteria
APP7_1704	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APP7_1706	COG2168	tRNA wobble position uridine thiolation
APP7_1708	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APP7_1709	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APP7_1711	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APP7_1718	COG0561	phosphatase activity
APP7_1719	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APP7_1720	COG3012	SEC-C Motif Domain Protein
APP7_1722	COG3716	PTS system mannose fructose sorbose family IID component
APP7_1723	COG3715	PTS system
APP7_1724	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APP7_1724	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APP7_1725	COG2610	gluconate transmembrane transporter activity
APP7_1726	COG3265	gluconokinase activity
APP7_1727	COG1609	Transcriptional regulator
APP7_1731	COG1172	Belongs to the binding-protein-dependent transport system permease family
APP7_1732	COG1879	ABC-type sugar transport system periplasmic component
APP7_1733	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP7_1734	COG0243	molybdopterin cofactor binding
APP7_1735	COG0437	4 iron, 4 sulfur cluster binding
APP7_1736	COG3302	dmso reductase anchor subunit
APP7_1737	COG3381	protein complex oligomerization
APP7_1738	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APP7_1738	COG2221	Nitrite and sulphite reductase 4Fe-4S
APP7_1744	COG1349	DNA-binding transcription factor activity
APP7_1745	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
APP7_1746	COG1070	Carbohydrate kinase
APP7_1747	COG4154	Belongs to the RbsD FucU family
APP7_1748	COG0235	Class ii aldolase
APP7_1749	COG0738	Major facilitator superfamily
APP7_1750	COG1454	alcohol dehydrogenase
APP7_1751	COG3477	response to acidic pH
APP7_1754	COG1126	abc transporter atp-binding protein
APP7_1755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APP7_1759	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APP7_1764	COG3623	hexulose-6-phosphate isomerase
APP7_1765	COG0235	Class ii aldolase
APP7_1766	COG0545	Peptidyl-prolyl cis-trans isomerase
APP7_1772	COG0758	DNA mediated transformation
APP7_1773	COG1297	OPT oligopeptide transporter protein
APP7_1776	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APP7_1778	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APP7_1779	COG0081	regulation of translation
APP7_1780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APP7_1781	COG0222	ribosome binding
APP7_1788	COG0085	RNA polymerase activity
APP7_1796	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APP7_1797	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APP7_1798	COG1489	DNA binding
APP7_1799	COG0346	lactoylglutathione lyase activity
APP7_1800	COG1194	a g-specific adenine glycosylase
APP7_1801	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APP7_1802	COG0741	lytic transglycosylase activity
APP7_1810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APP7_1813	COG0737	Belongs to the 5'-nucleotidase family
APP7_1814	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APP7_1815	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APP7_1816	COG0606	chelatase, subunit chli
APP7_1818	COG0210	DNA helicase
APP7_1824	COG0640	Transcriptional regulator
APP7_1832	COG0606	chelatase, subunit chli
APP7_1834	COG2267	carboxylic ester hydrolase activity
APP7_1837	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APP7_1839	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APP7_1840	COG0363	glucosamine-6-phosphate deaminase activity
APP7_1841	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APP7_1844	COG0051	transcription antitermination factor activity, RNA binding
APP7_1845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APP7_1846	COG0088	Forms part of the polypeptide exit tunnel
APP7_1847	COG0089	rRNA binding
APP7_1848	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APP7_1849	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APP7_1850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APP7_1851	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APP7_1852	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APP7_1853	COG0255	Belongs to the universal ribosomal protein uL29 family
APP7_1854	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APP7_1856	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APP7_1857	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APP7_1858	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APP7_1859	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APP7_1860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APP7_1861	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APP7_1862	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APP7_1863	COG1841	ribosomal large subunit assembly
APP7_1865	COG0201	protein transport
APP7_1867	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APP7_1868	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APP7_1869	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APP7_1870	COG0202	RNA polymerase activity
APP7_1872	COG0228	four-way junction DNA binding
APP7_1873	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APP7_1874	COG0336	Belongs to the RNA methyltransferase TrmD family
APP7_1875	COG0335	large ribosomal subunit rRNA binding
APP7_1876	COG2850	peptidyl-arginine hydroxylation
APP7_1878	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP7_1887	COG2852	Protein conserved in bacteria
APP7_1893	COG2832	Protein of unknown function (DUF454)
APP7_1894	COG1215	transferase activity, transferring glycosyl groups
APP7_1895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APP7_1897	COG0084	hydrolase, TatD family'
APP7_1900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APP7_1902	COG0470	DNA polymerase III
APP7_1903	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APP7_1904	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APP7_1905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APP7_1906	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APP7_1907	COG0254	rRNA binding
APP7_1908	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APP7_1909	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APP7_1910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APP7_1911	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APP7_1913	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APP7_1918	COG1595	DNA-templated transcription, initiation
APP7_1919	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APP7_1921	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APP7_1924	COG2502	aspartate--ammonia ligase
APP7_1925	COG1522	sequence-specific DNA binding
APP7_1926	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APP7_1930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APP7_1935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APP7_1937	COG4208	sulfate ABC transporter
APP7_1938	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APP7_1939	COG1304	FMN binding
APP7_1940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APP7_1940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APP7_1941	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APP7_1943	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APP7_1944	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APP7_1945	COG2995	paraquat-inducible protein a
APP7_1946	COG1305	Transglutaminase-like
APP7_1948	COG2608	mercury ion transmembrane transporter activity
APP7_1949	COG1979	alcohol dehydrogenase
APP7_1950	COG0583	DNA-binding transcription factor activity
APP7_1951	COG2171	N-acyltransferase activity
APP7_1952	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APP7_1954	COG0511	ligase activity, forming carbon-carbon bonds
APP7_1955	COG0439	Biotin carboxylase
APP7_1957	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APP7_1958	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APP7_1958	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APP7_1959	COG0742	ribosomal rna small subunit methyltransferase
APP7_1960	COG1876	peptidase activity
APP7_1961	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APP7_1962	COG1393	Belongs to the ArsC family
APP7_1964	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APP7_1965	COG0564	pseudouridine synthase activity
APP7_1967	COG0668	transmembrane transport
APP7_1968	COG0439	Biotin carboxylase
APP7_1970	COG1025	Belongs to the peptidase M16 family
APP7_1971	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APP7_1976	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APP7_1977	COG1067	ATP-dependent peptidase activity
APP7_1978	COG3120	sequence-specific DNA binding
APP7_1979	COG0180	Tryptophanyl-tRNA synthetase
APP7_1983	COG0730	response to heat
APP7_1986	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APP7_1989	COG2116	formate transmembrane transporter activity
APP7_1991	COG2801	Transposase and inactivated derivatives
APP7_1992	COG2963	transposase activity
APP7_1996	COG1070	Carbohydrate kinase
APP7_1997	COG2115	Belongs to the xylose isomerase family
APP7_1998	COG4213	ABC transporter substrate-binding protein
APP7_1999	COG1129	ABC transporter
APP7_2000	COG4214	carbohydrate transport
APP7_2001	COG1609	Transcriptional regulator
APP7_2001	COG2207	Transcriptional regulator
APP7_2002	COG3590	peptidase
APP7_2004	COG4145	pantothenate transmembrane transporter activity
APP7_2005	COG3924	membrane
APP7_2006	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
APP7_2007	COG2853	Lipoprotein
APP7_2008	COG0676	glucose-6-phosphate 1-epimerase activity
APP7_2011	COG1649	PFAM Uncharacterised BCR, COG1649
APP7_2011	COG0726	polysaccharide deacetylase
APP7_2012	COG1215	transferase activity, transferring glycosyl groups
APP7_2014	COG0149	triose-phosphate isomerase activity
APP7_2016	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APP7_2017	COG1238	metal cluster binding
APP7_2020	COG4942	peptidase
APP7_2020	COG1388	LysM domain
APP7_2021	COG2818	Glycosylase
APP7_2023	COG0700	Nucleoside recognition
APP7_2024	COG3366	ferrous iron transmembrane transporter activity
APP7_2026	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APP7_2027	COG0594	ribonuclease P activity
APP7_2028	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APP7_2029	COG0174	glutamine synthetase
APP7_2030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APP7_2031	COG0494	nUDIX hydrolase
APP7_2032	COG3223	Belongs to the PsiE family
APP7_2037	COG1490	D-aminoacyl-tRNA deacylase activity
APP7_2038	COG1295	ribonuclease BN
APP7_2047	COG1064	alcohol dehydrogenase
APP7_2049	COG1923	regulation of RNA biosynthetic process
APP7_2050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APP7_2051	COG1611	Belongs to the LOG family
APP7_2052	COG1694	Mazg nucleotide pyrophosphohydrolase
APP7_2055	COG1309	transcriptional regulator
APP7_2057	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APP7_2058	COG2003	Belongs to the UPF0758 family
APP7_2059	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APP7_2060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APP7_2062	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APP7_2063	COG0076	glutamate decarboxylase activity
APP7_2064	COG0425	Belongs to the sulfur carrier protein TusA family
APP7_2065	COG2391	methyltransferase activity
APP7_2066	COG3085	chromosome segregation
APP7_2068	COG0598	Magnesium transport protein CorA
APP7_2069	COG2226	methyltransferase
APP7_2072	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APP7_2073	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APP7_2074	COG0805	protein transport
APP7_2078	COG1114	Component of the transport system for branched-chain amino acids
APP7_2079	COG1028	Short-chain dehydrogenase reductase Sdr
APP7_2080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APP7_2081	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APP7_2082	COG0142	geranyltranstransferase activity
APP7_2084	COG0431	NADPH-dependent FMN reductase
APP7_2085	COG2259	Doxx family
APP7_2087	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APP7_2088	COG0697	spore germination
APP7_2091	COG1040	competence protein
APP7_2094	COG0456	acetyltransferase
APP7_2095	COG0513	Belongs to the DEAD box helicase family
APP7_2097	COG0747	negative chemotaxis
APP7_2099	COG1584	GPR1 FUN34 yaaH family protein
APP7_2100	COG1120	ATPase activity
APP7_2101	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APP7_2102	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APP7_2107	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APP7_2108	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APP7_2112	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APP7_2115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APP7_2115	COG0140	phosphoribosyl-ATP diphosphatase activity
APP7_2116	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APP7_2117	COG0024	Methionine aminopeptidase
APP7_2120	COG1621	beta-fructofuranosidase activity
APP7_2121	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APP7_2123	COG4591	ABC-type transport system involved in lipoprotein release permease component
APP7_2124	COG1136	(ABC) transporter
APP7_2125	COG4591	ABC-type transport system involved in lipoprotein release permease component
APP7_2126	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APP7_A0002	COG2826	transposase and inactivated derivatives, IS30 family