locus-tag	class	description
KV188_00135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KV188_00145	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KV188_00155	COG0589	response to stress
KV188_00165	COG2969	positive regulation of protein catabolic process
KV188_00170	COG0625	glutathione transferase activity
KV188_00175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KV188_00185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KV188_00190	COG1448	Aminotransferase
KV188_00195	COG0006	proline dipeptidase activity
KV188_00205	COG1487	ribonuclease activity
KV188_00215	COG0556	nucleotide-excision repair
KV188_00220	COG2822	iron ion transport
KV188_00225	COG2837	iron assimilation
KV188_00235	COG0613	PHP domain protein
KV188_00245	COG2925	Exonuclease
KV188_00250	COG0038	chloride channel
KV188_00255	COG0017	Asparaginyl-tRNA synthetase
KV188_00260	COG1509	lysine 2,3-aminomutase activity
KV188_00270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KV188_00275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KV188_00280	COG2814	Major facilitator Superfamily
KV188_00285	COG0741	lytic transglycosylase activity
KV188_00290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KV188_00295	COG0626	cystathionine gamma-synthase activity
KV188_00300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KV188_00320	COG2363	Small membrane protein
KV188_00325	COG0277	FAD linked oxidase domain protein
KV188_00330	COG0243	molybdopterin cofactor binding
KV188_00335	COG3005	denitrification pathway
KV188_00345	COG0315	cyclic pyranopterin monophosphate synthase activity
KV188_00350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KV188_00355	COG0314	molybdopterin synthase activity
KV188_00360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KV188_00365	COG1444	tRNA N-acetyltransferase activity
KV188_00375	COG0583	DNA-binding transcription factor activity
KV188_00380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KV188_00380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KV188_00400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KV188_00405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KV188_00420	COG1737	Transcriptional regulator
KV188_00425	COG2731	YhcH YjgK YiaL family protein
KV188_00430	COG0248	Ppx GppA phosphatase
KV188_00435	COG2926	Belongs to the UPF0265 family
KV188_00440	COG0527	aspartate kinase activity
KV188_00445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KV188_00450	COG3100	YcgL domain-containing protein
KV188_00455	COG0305	Participates in initiation and elongation during chromosome replication
KV188_00460	COG4607	ABC-type enterochelin transport system periplasmic component
KV188_00465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KV188_00470	COG4605	iron ion homeostasis
KV188_00475	COG4604	ABC transporter, ATP-binding protein
KV188_00480	COG1392	Phosphate transport regulator
KV188_00485	COG0306	phosphate transporter
KV188_00490	COG4991	sh3 domain protein
KV188_00500	COG3945	hemerythrin HHE cation binding domain
KV188_00505	COG0343	queuine tRNA-ribosyltransferase activity
KV188_00515	COG1278	Cold shock
KV188_00520	COG0288	reversible hydration of carbon dioxide
KV188_00525	COG0028	Belongs to the TPP enzyme family
KV188_00530	COG0440	acetolactate synthase activity
KV188_00535	COG0312	modulator of DNA gyrase
KV188_00540	COG3028	Belongs to the UPF0307 family
KV188_00545	COG3094	Invasion gene expression up-regulator, SirB
KV188_00555	COG1811	Na channel or pump
KV188_00560	COG3787	Belongs to the UPF0306 family
KV188_00565	COG0023	Translation Initiation Factor
KV188_00570	COG0284	orotidine-5'-phosphate decarboxylase activity
KV188_00575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KV188_00580	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
KV188_00585	COG0776	regulation of translation
KV188_00590	COG0539	negative regulation of cytoplasmic translation
KV188_00600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KV188_00610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KV188_00620	COG1785	Belongs to the alkaline phosphatase family
KV188_00625	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
KV188_00635	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KV188_00635	COG3264	Mechanosensitive ion channel
KV188_00640	COG3264	Mechanosensitive ion channel
KV188_00640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KV188_00645	COG0318	PFAM AMP-dependent synthetase and ligase
KV188_00650	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KV188_00655	COG0596	Alpha beta hydrolase
KV188_00665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KV188_00685	COG1380	Effector of murein hydrolase LrgA
KV188_00690	COG1346	cytolysis
KV188_00705	COG3036	rescue of stalled ribosome
KV188_00710	COG2226	methyltransferase
KV188_00730	COG0658	competence protein
KV188_00730	COG2333	competence protein COMEC
KV188_00735	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KV188_00740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KV188_00745	COG0737	Belongs to the 5'-nucleotidase family
KV188_00770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KV188_00775	COG0508	dehydrogenase complex catalyzes the overall conversion of
KV188_00780	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KV188_00785	COG0167	dihydroorotate dehydrogenase activity
KV188_00790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KV188_00805	COG1132	(ABC) transporter
KV188_00810	COG1346	cytolysis
KV188_00820	COG1199	ATP-dependent helicase activity
KV188_00830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KV188_00835	COG0629	single-stranded DNA binding
KV188_00845	COG0604	alcohol dehydrogenase
KV188_00845	COG1028	Short-chain dehydrogenase reductase Sdr
KV188_00845	COG3321	synthase
KV188_00850	COG0789	Transcriptional regulator
KV188_00880	COG2070	2-Nitropropane dioxygenase
KV188_00885	COG2814	Major facilitator Superfamily
KV188_00890	COG2315	Protein conserved in bacteria
KV188_00895	COG4172	Belongs to the ABC transporter superfamily
KV188_00900	COG4171	peptide transport system, permease
KV188_00905	COG4168	peptide transport system, permease
KV188_00910	COG4166	transmembrane transport
KV188_00915	COG3283	Transcriptional regulator of aromatic amino acids metabolism
KV188_00920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KV188_00925	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KV188_00930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KV188_00935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KV188_00940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KV188_00950	COG1368	sulfuric ester hydrolase activity
KV188_00955	COG0633	Ferredoxin
KV188_00955	COG3217	Mosc domain protein beta barrel domain protein
KV188_00960	COG1722	exodeoxyribonuclease VII activity
KV188_00965	COG0142	geranyltranstransferase activity
KV188_00975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KV188_00980	COG1530	ribonuclease E activity
KV188_00985	COG1944	ATP diphosphatase activity
KV188_00990	COG0500	methyltransferase
KV188_01000	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KV188_01020	COG2351	hydroxyisourate hydrolase activity
KV188_01030	COG0586	Pfam SNARE associated Golgi protein
KV188_01035	COG0187	DNA topoisomerase II activity
KV188_01040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KV188_01045	COG1349	DNA-binding transcription factor activity
KV188_01050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KV188_01055	COG2915	High frequency lysogenization protein hflD homolog
KV188_01060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KV188_01065	COG4988	ABC transporter
KV188_01070	COG2911	Protein conserved in bacteria
KV188_01075	COG0729	surface antigen
KV188_01080	COG2861	carbohydrate metabolic process
KV188_01085	COG4942	peptidase
KV188_01090	COG0588	phosphoglycerate mutase activity
KV188_01100	COG0572	uridine kinase
KV188_01105	COG0717	Belongs to the dCTP deaminase family
KV188_01110	COG1309	transcriptional regulator
KV188_01115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KV188_01120	COG0842	Transport permease protein
KV188_01120	COG1129	ABC transporter
KV188_01125	COG0842	Transport permease protein
KV188_01140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KV188_01145	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KV188_01165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KV188_01170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KV188_01180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KV188_01185	COG4166	transmembrane transport
KV188_01195	COG0444	Belongs to the ABC transporter superfamily
KV188_01200	COG4608	Belongs to the ABC transporter superfamily
KV188_01205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KV188_01210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KV188_01220	COG0747	negative chemotaxis
KV188_01225	COG0814	amino acid
KV188_01230	COG1760	l-serine dehydratase
KV188_01240	COG0134	indole-3-glycerol-phosphate synthase activity
KV188_01240	COG0135	phosphoribosylanthranilate isomerase activity
KV188_01245	COG3177	Filamentation induced by cAMP protein fic
KV188_01250	COG3098	single-species biofilm formation
KV188_01255	COG0564	pseudouridine synthase activity
KV188_01260	COG3140	Belongs to the UPF0181 family
KV188_01270	COG3025	triphosphatase activity
KV188_01275	COG3106	COG3106 Predicted ATPase
KV188_01280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KV188_01290	COG1473	amidohydrolase
KV188_01295	COG3069	C4-dicarboxylate transmembrane transporter activity
KV188_01305	COG0495	leucyl-tRNA aminoacylation
KV188_01310	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
KV188_01315	COG1466	dna polymerase III delta subunit
KV188_01320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KV188_01325	COG0237	dephospho-CoA kinase activity
KV188_01335	COG1459	type II secretion system
KV188_01340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KV188_01345	COG4969	Belongs to the N-Me-Phe pilin family
KV188_01350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KV188_01360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KV188_01365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KV188_01370	COG0730	response to heat
KV188_01375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KV188_01380	COG0183	Belongs to the thiolase family
KV188_01385	COG1250	3-hydroxyacyl-CoA dehydrogenase
KV188_01385	COG1024	Enoyl-CoA hydratase
KV188_01400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KV188_01410	COG0437	4 iron, 4 sulfur cluster binding
KV188_01415	COG2864	formate dehydrogenase
KV188_01420	COG3058	Necessary for formate dehydrogenase activity
KV188_01450	COG1560	Kdo2-lipid A biosynthetic process
KV188_01455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KV188_01465	COG0302	gtp cyclohydrolase
KV188_01470	COG3642	lipopolysaccharide core region biosynthetic process
KV188_01480	COG0110	maltose O-acetyltransferase activity
KV188_01490	COG0583	DNA-binding transcription factor activity
KV188_01510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KV188_01520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KV188_01525	COG0617	tRNA 3'-terminal CCA addition
KV188_01555	COG2975	iron-sulfur cluster assembly
KV188_01560	COG0633	Ferredoxin
KV188_01580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KV188_01590	COG0822	iron-sulfur transferase activity
KV188_01595	COG1104	cysteine desulfurase activity
KV188_01600	COG1959	2 iron, 2 sulfur cluster binding
KV188_01610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KV188_01615	COG2198	Histidine kinase
KV188_01615	COG5002	protein histidine kinase activity
KV188_01615	COG0784	Response regulator, receiver
KV188_01620	COG0697	spore germination
KV188_01625	COG2840	Smr protein MutS2
KV188_01630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KV188_01635	COG2226	methyltransferase
KV188_01640	COG2830	Protein of unknown function (DUF452)
KV188_01645	COG0156	8-amino-7-oxononanoate synthase activity
KV188_01650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KV188_01660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KV188_01665	COG2027	D-alanyl-D-alanine carboxypeptidase
KV188_01685	COG2801	Transposase and inactivated derivatives
KV188_01695	COG2856	Zn peptidase
KV188_01700	COG3620	sequence-specific DNA binding
KV188_01740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KV188_01745	COG0138	bifunctional purine biosynthesis protein purh
KV188_01775	COG2831	hemolysin activation secretion protein
KV188_01780	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KV188_01785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KV188_01795	COG3078	GTPase activator activity
KV188_01805	COG0786	glutamate:sodium symporter activity
KV188_01820	COG2350	Protein conserved in bacteria
KV188_01825	COG1607	acyl-coa hydrolase
KV188_01840	COG3092	negative regulation of chromosome organization
KV188_01850	COG2056	Na+-H+ antiporter family
KV188_01855	COG0708	Exodeoxyribonuclease III
KV188_01860	COG0583	DNA-binding transcription factor activity
KV188_01880	COG0254	rRNA binding
KV188_01895	COG0753	catalase activity
KV188_01905	COG1408	metallophosphoesterase
KV188_01910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KV188_01915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KV188_01920	COG1085	galactose-1-phosphate uridylyltransferase
KV188_01930	COG2017	converts alpha-aldose to the beta-anomer
KV188_01965	COG0489	protein tyrosine kinase activity
KV188_01975	COG2095	MarC family integral membrane protein
KV188_01980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KV188_01990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KV188_01995	COG2354	Protein conserved in bacteria
KV188_02000	COG3071	HemY protein
KV188_02005	COG2959	enzyme of heme biosynthesis
KV188_02015	COG0181	hydroxymethylbilane synthase activity
KV188_02020	COG1012	belongs to the aldehyde dehydrogenase family
KV188_02020	COG1454	alcohol dehydrogenase
KV188_02035	COG0813	purine-nucleoside phosphorylase activity
KV188_02045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KV188_02050	COG2364	Membrane
KV188_02055	COG0800	Aldolase
KV188_02060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KV188_02075	COG2186	Transcriptional regulator
KV188_02085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KV188_02085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KV188_02090	COG1216	Glycosyl transferase, family 2
KV188_02095	COG1216	Glycosyl transferase, family 2
KV188_02105	COG3306	glycosyltransferase involved in LPS biosynthesis
KV188_02115	COG5039	Polysaccharide pyruvyl transferase
KV188_02120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KV188_02125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KV188_02130	COG0077	Prephenate dehydratase
KV188_02130	COG1605	Chorismate mutase
KV188_02135	COG0339	signal peptide processing
KV188_02140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KV188_02145	COG1882	Formate acetyltransferase
KV188_02150	COG2116	formate transmembrane transporter activity
KV188_02155	COG1238	metal cluster binding
KV188_02160	COG0501	Belongs to the peptidase M48B family
KV188_02165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KV188_02170	COG2431	L-lysine efflux transmembrane transporter activity
KV188_02175	COG1169	isochorismate synthase
KV188_02180	COG0436	Aminotransferase
KV188_02185	COG2962	Rard protein
KV188_02190	COG2962	Rard protein
KV188_02195	COG1280	lysine exporter protein (LysE YggA)
KV188_02200	COG4771	TonB-dependent receptor
KV188_02200	COG1629	transport
KV188_02205	COG0748	coenzyme F420 binding
KV188_02215	COG4235	cytochrome complex assembly
KV188_02215	COG3088	subunit of a heme lyase
KV188_02220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KV188_02225	COG1138	Cytochrome C-type biogenesis protein
KV188_02230	COG0475	glutathione-regulated potassium exporter activity
KV188_02230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KV188_02240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KV188_02250	COG3111	PFAM Bacterial OB fold (BOF) protein
KV188_02265	COG0745	RESPONSE REGULATOR receiver
KV188_02270	COG0642	Histidine kinase
KV188_02275	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KV188_02280	COG1862	Preprotein translocase
KV188_02285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KV188_02290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KV188_02295	COG1528	Iron-storage protein
KV188_02300	COG1528	Iron-storage protein
KV188_02305	COG2252	PERMEase
KV188_02310	COG0424	maF-like protein
KV188_02320	COG0301	tRNA thio-modification
KV188_02320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KV188_02325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KV188_02330	COG0330	HflC and HflK could
KV188_02335	COG0330	HflC and HflK could
KV188_02340	COG3118	belongs to the thioredoxin family
KV188_02360	COG0531	amino acid
KV188_02365	COG0531	amino acid
KV188_02380	COG3047	cAMP biosynthetic process
KV188_02385	COG0542	response to heat
KV188_02390	COG0798	PFAM Bile acid sodium symporter
KV188_02395	COG1393	Belongs to the ArsC family
KV188_02405	COG1027	Aspartate ammonia-lyase
KV188_02415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KV188_02430	COG0720	synthase
KV188_02435	COG0602	queuosine metabolic process
KV188_02460	COG0795	lipopolysaccharide-transporting ATPase activity
KV188_02465	COG0795	lipopolysaccharide-transporting ATPase activity
KV188_02490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KV188_02510	COG0861	Integral membrane protein TerC family
KV188_02520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KV188_02525	COG0148	phosphopyruvate hydratase activity
KV188_02530	COG1051	belongs to the nudix hydrolase family
KV188_02535	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
KV188_02555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KV188_02560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KV188_02565	COG0564	pseudouridine synthase activity
KV188_02575	COG0205	6-phosphofructokinase activity
KV188_02580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KV188_02585	COG1525	nuclease
KV188_02590	COG1115	amino acid carrier protein
KV188_02595	COG0628	permease
KV188_02605	COG0826	peptidase U32
KV188_02610	COG3307	-O-antigen
KV188_02615	COG1519	Transferase
KV188_02625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KV188_02630	COG0802	atpase or kinase
KV188_02635	COG0860	N-Acetylmuramoyl-L-alanine amidase
KV188_02635	COG1388	LysM domain
KV188_02640	COG0166	Belongs to the GPI family
KV188_02645	COG2960	long-chain fatty acid transporting porin activity
KV188_02670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KV188_02680	COG0551	DNA topoisomerase type I activity
KV188_02690	COG2137	regulation of response to DNA damage stimulus
KV188_02695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KV188_02700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KV188_02710	COG1322	Protein conserved in bacteria
KV188_02715	COG0512	Glutamine amidotransferase of anthranilate synthase
KV188_02730	COG0494	nUDIX hydrolase
KV188_02735	COG0217	transcriptional regulatory protein
KV188_02745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KV188_02750	COG0612	Peptidase, M16
KV188_02760	COG0471	metal ion transport
KV188_02765	COG0583	DNA-binding transcription factor activity
KV188_02770	COG3266	domain, Protein
KV188_02780	COG1187	pseudouridine synthase activity
KV188_02785	COG0009	L-threonylcarbamoyladenylate synthase
KV188_02790	COG2837	iron assimilation
KV188_02795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KV188_02800	COG0512	Glutamine amidotransferase of anthranilate synthase
KV188_02810	COG2226	methyltransferase
KV188_02815	COG2268	Band 7 protein
KV188_02820	COG2841	Protein conserved in bacteria
KV188_02825	COG0359	binds to the 23S rRNA
KV188_02835	COG2965	DNA replication, synthesis of RNA primer
KV188_02850	COG3201	nicotinamide mononucleotide transporter
KV188_02855	COG2976	Protein conserved in bacteria
KV188_02865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KV188_02870	COG1426	Protein conserved in bacteria
KV188_02875	COG0659	secondary active sulfate transmembrane transporter activity
KV188_02885	COG0673	inositol 2-dehydrogenase activity
KV188_02890	COG0475	glutathione-regulated potassium exporter activity
KV188_02890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KV188_02895	COG1373	ATPase (AAA superfamily
KV188_02930	COG2207	Transcriptional regulator
KV188_02940	COG1902	pentaerythritol trinitrate reductase activity
KV188_02945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KV188_02950	COG2084	Dehydrogenase
KV188_02955	COG0778	Nitroreductase
KV188_02960	COG2095	MarC family integral membrane protein
KV188_02975	COG0625	glutathione transferase activity
KV188_02995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KV188_03010	COG1275	C4-dicarboxylate transporter malic acid transport protein
KV188_03015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KV188_03030	COG1132	(ABC) transporter
KV188_03035	COG1854	S-ribosylhomocysteine lyase activity
KV188_03040	COG3008	intermembrane lipid transfer
KV188_03045	COG0735	belongs to the Fur family
KV188_03050	COG0716	FMN binding
KV188_03060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KV188_03065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KV188_03070	COG2252	PERMEase
KV188_03075	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KV188_03080	COG2081	HI0933 family
KV188_03085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KV188_03095	COG0560	Phosphoserine phosphatase
KV188_03100	COG1666	GTP binding
KV188_03110	COG0058	SHG alpha-glucan phosphorylase activity
KV188_03115	COG2909	trisaccharide binding
KV188_03140	COG3833	ABC-type maltose transport systems, permease component
KV188_03145	COG1640	4-alpha-glucanotransferase
KV188_03150	COG1966	Carbon starvation protein
KV188_03155	COG0084	hydrolase, TatD family'
KV188_03160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KV188_03170	COG0778	Nitroreductase
KV188_03185	COG4172	Belongs to the ABC transporter superfamily
KV188_03190	COG0191	fructose-bisphosphate aldolase activity
KV188_03195	COG0126	phosphoglycerate kinase activity
KV188_03200	COG0471	metal ion transport
KV188_03205	COG0471	metal ion transport
KV188_03210	COG0471	metal ion transport
KV188_03215	COG0187	DNA topoisomerase II activity
KV188_03225	COG0745	RESPONSE REGULATOR receiver
KV188_03250	COG0789	Transcriptional regulator
KV188_03260	COG2217	Heavy metal translocating P-type atpase
KV188_03270	COG0300	oxidoreductase activity
KV188_03275	COG0778	Nitroreductase
KV188_03280	COG0616	signal peptide processing
KV188_03285	COG3719	Belongs to the RNase T2 family
KV188_03295	COG1252	NADH dehydrogenase
KV188_03300	COG2183	response to ionizing radiation
KV188_03305	COG3063	Type IV pilus biogenesis stability protein PilW
KV188_03345	COG2161	toxin-antitoxin pair type II binding
KV188_03350	COG4115	mRNA cleavage
KV188_03355	COG2835	tetraacyldisaccharide 4'-kinase activity
KV188_03360	COG1663	tetraacyldisaccharide 4'-kinase activity
KV188_03365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KV188_03370	COG0740	serine-type endopeptidase activity
KV188_03375	COG2166	iron-sulfur cluster assembly
KV188_03395	COG0488	(ABC) transporter
KV188_03400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KV188_03415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KV188_03420	COG5007	Belongs to the BolA IbaG family
KV188_03430	COG2854	intermembrane phospholipid transfer
KV188_03435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KV188_03440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KV188_03445	COG1127	ABC transporter
KV188_03450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KV188_03455	COG1090	epimerase
KV188_03475	COG0563	adenylate kinase activity
KV188_03485	COG2814	Major facilitator Superfamily
KV188_03515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KV188_03525	COG1794	racemase activity, acting on amino acids and derivatives
KV188_03530	COG2814	Major facilitator Superfamily
KV188_03535	COG0363	glucosamine-6-phosphate deaminase activity
KV188_03540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KV188_03545	COG1218	3'(2'),5'-bisphosphate nucleotidase
KV188_03550	COG0494	nUDIX hydrolase
KV188_03555	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KV188_03560	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KV188_03565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KV188_03570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KV188_03575	COG0549	Belongs to the carbamate kinase family
KV188_03585	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KV188_03590	COG1178	ABC-type Fe3 transport system permease component
KV188_03595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV188_03600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KV188_03605	COG2190	(PTS) system
KV188_03615	COG0210	DNA helicase
KV188_03620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KV188_03625	COG0409	Hydrogenase expression formation protein
KV188_03630	COG0309	Hydrogenase expression formation protein (HypE)
KV188_03655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KV188_03660	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
KV188_03665	COG0437	4 iron, 4 sulfur cluster binding
KV188_03670	COG5557	Pfam Polysulphide reductase, NrfD
KV188_03675	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
KV188_03680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KV188_03685	COG1773	rubredoxin
KV188_03690	COG0298	carbon dioxide binding
KV188_03695	COG0375	protein maturation
KV188_03720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KV188_03725	COG0308	aminopeptidase N
KV188_03730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KV188_03735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KV188_03740	COG0295	cytidine deaminase activity
KV188_03745	COG2177	Part of the ABC transporter FtsEX involved in
KV188_03750	COG2884	Cell division ATP-binding protein ftsE
KV188_03755	COG0552	protein localization to endoplasmic reticulum
KV188_03760	COG0742	ribosomal rna small subunit methyltransferase
KV188_03765	COG3099	Belongs to the UPF0263 family
KV188_03770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KV188_03780	COG4160	amino acid transport
KV188_03785	COG4215	(ABC) transporter
KV188_03790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KV188_03795	COG1126	abc transporter atp-binding protein
KV188_03800	COG1881	PFAM PEBP family protein
KV188_03810	COG3620	sequence-specific DNA binding
KV188_03820	COG4232	protein-disulfide reductase activity
KV188_03825	COG3101	peptidyl-lysine hydroxylation
KV188_03835	COG3107	peptidoglycan biosynthetic process
KV188_03845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KV188_03880	COG1138	Cytochrome C-type biogenesis protein
KV188_03890	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KV188_03895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KV188_03900	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KV188_03905	COG4133	protoheme IX ABC transporter activity
KV188_03910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KV188_03945	COG3630	sodium ion export across plasma membrane
KV188_03955	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KV188_03960	COG2824	Alkylphosphonate utilization operon protein PhnA
KV188_03965	COG1858	cytochrome C peroxidase
KV188_03970	COG1872	DUF167
KV188_03975	COG0762	integral membrane protein
KV188_03980	COG3171	Protein conserved in bacteria
KV188_03985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KV188_03990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KV188_03995	COG0416	fatty acid biosynthetic process
KV188_04000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KV188_04005	COG1399	metal-binding, possibly nucleic acid-binding protein
KV188_04010	COG4137	Cytochrome C assembly protein
KV188_04015	COG4536	flavin adenine dinucleotide binding
KV188_04020	COG0733	neurotransmitter:sodium symporter activity
KV188_04030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV188_04030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV188_04035	COG3715	PTS system
KV188_04040	COG3716	PTS system mannose fructose sorbose family IID component
KV188_04075	COG1840	ABC-type Fe3 transport system, periplasmic component
KV188_04090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KV188_04110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KV188_04115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KV188_04120	COG0049	tRNA binding
KV188_04125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KV188_04130	COG0859	PFAM glycosyl transferase family 9
KV188_04135	COG0859	PFAM glycosyl transferase family 9
KV188_04145	COG3266	domain, Protein
KV188_04145	COG3061	Opacity-associated protein A
KV188_04150	COG1555	photosystem II stabilization
KV188_04180	COG4974	Belongs to the 'phage' integrase family
KV188_04200	COG0814	amino acid
KV188_04205	COG3691	Protein conserved in bacteria
KV188_04210	COG4989	oxidoreductase activity
KV188_04215	COG1022	Amp-dependent synthetase and ligase
KV188_04240	COG4211	Belongs to the binding-protein-dependent transport system permease family
KV188_04245	COG1129	ABC transporter
KV188_04250	COG1879	ABC-type sugar transport system periplasmic component
KV188_04255	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KV188_04255	COG2885	chlorophyll binding
KV188_04260	COG0277	FAD linked oxidase domain protein
KV188_04260	COG0247	lactate metabolic process
KV188_04265	COG2050	protein possibly involved in aromatic compounds catabolism
KV188_04275	COG3005	denitrification pathway
KV188_04280	COG3043	anaerobic respiration
KV188_04285	COG0348	domain, Protein
KV188_04290	COG0437	4 iron, 4 sulfur cluster binding
KV188_04295	COG0243	molybdopterin cofactor binding
KV188_04305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KV188_04310	COG2249	NAD(P)H dehydrogenase (quinone) activity
KV188_04325	COG1530	ribonuclease E activity
KV188_04335	COG1755	Isoprenylcysteine carboxyl methyltransferase
KV188_04345	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KV188_04360	COG0678	peroxiredoxin activity
KV188_04360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KV188_04365	COG0583	DNA-binding transcription factor activity
KV188_04370	COG1309	transcriptional regulator
KV188_04375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KV188_04380	COG0557	exoribonuclease II activity
KV188_04390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KV188_04395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KV188_04405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KV188_04425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KV188_04430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KV188_04435	COG0562	UDP-galactopyranose mutase
KV188_04440	COG2244	polysaccharide biosynthetic process
KV188_04450	COG0438	transferase activity, transferring glycosyl groups
KV188_04460	COG0438	transferase activity, transferring glycosyl groups
KV188_04470	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
KV188_04480	COG1575	Belongs to the MenA family. Type 1 subfamily
KV188_04485	COG1720	tRNA m6t6A37 methyltransferase activity
KV188_04495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KV188_04515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KV188_04520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KV188_04525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KV188_04555	COG0825	malonyl-CoA metabolic process
KV188_04565	COG0204	Acyl-transferase
KV188_04570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KV188_04595	COG0783	Belongs to the Dps family
KV188_04610	COG1289	transmembrane transporter activity
KV188_04615	COG1803	Methylglyoxal synthase
KV188_04620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KV188_04630	COG0525	valine-tRNA ligase activity
KV188_04645	COG3012	SEC-C Motif Domain Protein
KV188_04645	COG3318	Belongs to the UPF0149 family
KV188_04650	COG2153	protein acetylation
KV188_04655	COG2927	DNA polymerase III (CHI subunit)
KV188_04660	COG1652	LysM domain
KV188_04665	COG0544	peptidyl-prolyl cis-trans isomerase activity
KV188_04670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KV188_04680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KV188_04685	COG1045	serine acetyltransferase
KV188_04690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KV188_04720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KV188_04735	COG0521	Mo-molybdopterin cofactor biosynthetic process
KV188_04745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KV188_04755	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KV188_04770	COG0625	glutathione transferase activity
KV188_04775	COG0019	diaminopimelate decarboxylase activity
KV188_04785	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KV188_04790	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KV188_04795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KV188_04800	COG1053	succinate dehydrogenase
KV188_04805	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KV188_04810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KV188_04815	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KV188_04820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KV188_04830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KV188_04835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KV188_04840	COG2264	protein methyltransferase activity
KV188_04870	COG4974	Belongs to the 'phage' integrase family
KV188_04930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KV188_04945	COG1151	hydroxylamine reductase activity
KV188_04950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KV188_04955	COG2244	polysaccharide biosynthetic process
KV188_04960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KV188_04970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KV188_04980	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
KV188_05000	COG0728	peptidoglycan biosynthetic process
KV188_05005	COG0268	Binds directly to 16S ribosomal RNA
KV188_05010	COG0569	domain protein
KV188_05015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KV188_05020	COG3276	selenocysteine insertion sequence binding
KV188_05025	COG1921	L-seryl-tRNASec selenium transferase activity
KV188_05035	COG0716	FMN binding
KV188_05055	COG4771	TonB-dependent receptor
KV188_05055	COG1629	transport
KV188_05080	COG2431	L-lysine efflux transmembrane transporter activity
KV188_05095	COG3545	Serine hydrolase
KV188_05130	COG1216	Glycosyl transferase, family 2
KV188_05135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KV188_05145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KV188_05175	COG1119	ATPase activity
KV188_05180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KV188_05190	COG1739	Uncharacterized protein family UPF0029
KV188_05195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KV188_05200	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KV188_05205	COG1970	mechanosensitive ion channel activity
KV188_05210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KV188_05215	COG0321	lipoyl(octanoyl) transferase activity
KV188_05220	COG2921	Belongs to the UPF0250 family
KV188_05225	COG1686	Belongs to the peptidase S11 family
KV188_05230	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KV188_05235	COG0772	Belongs to the SEDS family
KV188_05240	COG0768	penicillin binding
KV188_05245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KV188_05250	COG0799	negative regulation of ribosome biogenesis
KV188_05260	COG1126	abc transporter atp-binding protein
KV188_05265	COG0765	amino acid transport
KV188_05270	COG3681	Belongs to the UPF0597 family
KV188_05275	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KV188_05285	COG3691	Protein conserved in bacteria
KV188_05330	COG0832	Belongs to the urease beta subunit family
KV188_05335	COG0831	urea catabolic process
KV188_05345	COG1122	ATPase activity
KV188_05350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KV188_05355	COG0310	cobalt ion transport
KV188_05360	COG0310	cobalt ion transport
KV188_05365	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
KV188_05370	COG0583	DNA-binding transcription factor activity
KV188_05380	COG0490	domain, Protein
KV188_05380	COG0471	metal ion transport
KV188_05385	COG3722	fumarate hydratase activity
KV188_05400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KV188_05405	COG1349	DNA-binding transcription factor activity
KV188_05420	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
KV188_05425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KV188_05430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KV188_05435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KV188_05440	COG2900	Belongs to the SlyX family
KV188_05445	COG0545	Peptidyl-prolyl cis-trans isomerase
KV188_05450	COG2964	Protein conserved in bacteria
KV188_05455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KV188_05465	COG2168	tRNA wobble position uridine thiolation
KV188_05500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KV188_05505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KV188_05515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KV188_05545	COG0445	tRNA wobble uridine modification
KV188_05550	COG0561	phosphatase activity
KV188_05555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KV188_05560	COG3012	SEC-C Motif Domain Protein
KV188_05570	COG3716	PTS system mannose fructose sorbose family IID component
KV188_05575	COG3715	PTS system
KV188_05580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV188_05580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KV188_05585	COG2610	gluconate transmembrane transporter activity
KV188_05590	COG3265	gluconokinase activity
KV188_05595	COG1609	Transcriptional regulator
KV188_05605	COG1869	D-ribose catabolic process
KV188_05615	COG1172	Belongs to the binding-protein-dependent transport system permease family
KV188_05620	COG1879	ABC-type sugar transport system periplasmic component
KV188_05625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KV188_05630	COG0243	molybdopterin cofactor binding
KV188_05635	COG0437	4 iron, 4 sulfur cluster binding
KV188_05640	COG3302	dmso reductase anchor subunit
KV188_05645	COG3381	protein complex oligomerization
KV188_05650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KV188_05650	COG2221	Nitrite and sulphite reductase 4Fe-4S
KV188_05680	COG1349	DNA-binding transcription factor activity
KV188_05695	COG4154	Belongs to the RbsD FucU family
KV188_05700	COG0235	Class ii aldolase
KV188_05705	COG0738	Major facilitator superfamily
KV188_05710	COG1454	alcohol dehydrogenase
KV188_05715	COG3477	response to acidic pH
KV188_05720	COG0765	amino acid transport
KV188_05735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KV188_05755	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KV188_05780	COG3623	hexulose-6-phosphate isomerase
KV188_05785	COG0235	Class ii aldolase
KV188_05790	COG0545	Peptidyl-prolyl cis-trans isomerase
KV188_05815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KV188_05825	COG0758	DNA mediated transformation
KV188_05830	COG1297	OPT oligopeptide transporter protein
KV188_05845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KV188_05855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KV188_05860	COG0081	regulation of translation
KV188_05865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KV188_05870	COG0222	ribosome binding
KV188_05920	COG0085	RNA polymerase activity
KV188_05945	COG1487	ribonuclease activity
KV188_05980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KV188_05990	COG0346	lactoylglutathione lyase activity
KV188_05995	COG1194	a g-specific adenine glycosylase
KV188_06000	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KV188_06005	COG0741	lytic transglycosylase activity
KV188_06035	COG0305	Participates in initiation and elongation during chromosome replication
KV188_06090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KV188_06095	COG0737	Belongs to the 5'-nucleotidase family
KV188_06100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KV188_06105	COG0606	chelatase, subunit chli
KV188_06115	COG2267	carboxylic ester hydrolase activity
KV188_06120	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KV188_06130	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KV188_06140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KV188_06145	COG0363	glucosamine-6-phosphate deaminase activity
KV188_06150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KV188_06165	COG0051	transcription antitermination factor activity, RNA binding
KV188_06170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KV188_06175	COG0088	Forms part of the polypeptide exit tunnel
KV188_06180	COG0089	rRNA binding
KV188_06185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KV188_06190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KV188_06195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KV188_06200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KV188_06205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KV188_06210	COG0255	Belongs to the universal ribosomal protein uL29 family
KV188_06215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KV188_06225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KV188_06230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KV188_06235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KV188_06240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KV188_06245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KV188_06250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KV188_06255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KV188_06260	COG1841	ribosomal large subunit assembly
KV188_06265	COG0200	Binds to the 23S rRNA
KV188_06270	COG0201	protein transport
KV188_06280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KV188_06285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KV188_06290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KV188_06295	COG0202	RNA polymerase activity
KV188_06305	COG0228	four-way junction DNA binding
KV188_06310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KV188_06315	COG0336	Belongs to the RNA methyltransferase TrmD family
KV188_06320	COG0335	large ribosomal subunit rRNA binding
KV188_06325	COG2850	peptidyl-arginine hydroxylation
KV188_06330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KV188_06335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KV188_06380	COG2852	Protein conserved in bacteria
KV188_06395	COG4106	trans-aconitate 2-methyltransferase activity
KV188_06410	COG2832	Protein of unknown function (DUF454)
KV188_06420	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KV188_06430	COG0084	hydrolase, TatD family'
KV188_06445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KV188_06455	COG0470	DNA polymerase III
KV188_06460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KV188_06465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KV188_06485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KV188_06490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KV188_06495	COG0254	rRNA binding
KV188_06500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KV188_06505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KV188_06510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KV188_06515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KV188_06525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KV188_06550	COG1595	DNA-templated transcription, initiation
KV188_06555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KV188_06565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KV188_06590	COG2502	aspartate--ammonia ligase
KV188_06595	COG1522	sequence-specific DNA binding
KV188_06600	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KV188_06605	COG3161	chorismate lyase activity
KV188_06680	COG4208	sulfate ABC transporter
KV188_06685	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KV188_06690	COG1304	FMN binding
KV188_06700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KV188_06710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KV188_06715	COG2995	paraquat-inducible protein a
KV188_06720	COG1305	Transglutaminase-like
KV188_06730	COG2608	mercury ion transmembrane transporter activity
KV188_06735	COG1979	alcohol dehydrogenase
KV188_06740	COG0583	DNA-binding transcription factor activity
KV188_06745	COG2171	N-acyltransferase activity
KV188_06750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KV188_06760	COG0511	ligase activity, forming carbon-carbon bonds
KV188_06765	COG0439	Biotin carboxylase
KV188_06775	COG3084	Protein conserved in bacteria
KV188_06780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KV188_06790	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KV188_06790	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KV188_06800	COG1876	peptidase activity
KV188_06810	COG1393	Belongs to the ArsC family
KV188_06820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KV188_06825	COG0564	pseudouridine synthase activity
KV188_06835	COG0668	transmembrane transport
KV188_06840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KV188_06850	COG1025	Belongs to the peptidase M16 family
KV188_06855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KV188_06880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KV188_06885	COG1067	ATP-dependent peptidase activity
KV188_06890	COG3120	sequence-specific DNA binding
KV188_06895	COG0180	Tryptophanyl-tRNA synthetase
KV188_06915	COG0730	response to heat
KV188_06930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KV188_06940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KV188_06945	COG2116	formate transmembrane transporter activity
KV188_06975	COG0443	Heat shock 70 kDa protein
KV188_06980	COG1070	Carbohydrate kinase
KV188_06985	COG2115	Belongs to the xylose isomerase family
KV188_06990	COG4213	ABC transporter substrate-binding protein
KV188_06995	COG1129	ABC transporter
KV188_07000	COG4214	carbohydrate transport
KV188_07005	COG1609	Transcriptional regulator
KV188_07005	COG2207	Transcriptional regulator
KV188_07010	COG3590	peptidase
KV188_07020	COG4145	pantothenate transmembrane transporter activity
KV188_07025	COG3924	membrane
KV188_07030	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
KV188_07035	COG2853	Lipoprotein
KV188_07040	COG0676	glucose-6-phosphate 1-epimerase activity
KV188_07055	COG1649	PFAM Uncharacterised BCR, COG1649
KV188_07055	COG0726	polysaccharide deacetylase
KV188_07060	COG1215	transferase activity, transferring glycosyl groups
KV188_07070	COG0149	triose-phosphate isomerase activity
KV188_07080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KV188_07085	COG1238	metal cluster binding
KV188_07100	COG1388	LysM domain
KV188_07100	COG4942	peptidase
KV188_07105	COG2818	Glycosylase
KV188_07115	COG0700	Nucleoside recognition
KV188_07120	COG3366	ferrous iron transmembrane transporter activity
KV188_07125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KV188_07130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KV188_07135	COG0594	ribonuclease P activity
KV188_07140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KV188_07145	COG0174	glutamine synthetase
KV188_07150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KV188_07155	COG0494	nUDIX hydrolase
KV188_07185	COG1490	D-aminoacyl-tRNA deacylase activity
KV188_07190	COG1295	ribonuclease BN
KV188_07215	COG1629	transport
KV188_07215	COG4771	TonB-dependent receptor
KV188_07235	COG1064	alcohol dehydrogenase
KV188_07245	COG1923	regulation of RNA biosynthetic process
KV188_07250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KV188_07260	COG1694	Mazg nucleotide pyrophosphohydrolase
KV188_07275	COG1309	transcriptional regulator
KV188_07285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KV188_07290	COG2003	Belongs to the UPF0758 family
KV188_07295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KV188_07300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KV188_07310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KV188_07315	COG0076	glutamate decarboxylase activity
KV188_07320	COG0425	Belongs to the sulfur carrier protein TusA family
KV188_07325	COG2391	methyltransferase activity
KV188_07330	COG3085	chromosome segregation
KV188_07350	COG0598	Magnesium transport protein CorA
KV188_07355	COG2226	methyltransferase
KV188_07370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KV188_07375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KV188_07380	COG0805	protein transport
KV188_07400	COG1114	Component of the transport system for branched-chain amino acids
KV188_07405	COG1028	Short-chain dehydrogenase reductase Sdr
KV188_07410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KV188_07415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KV188_07420	COG0142	geranyltranstransferase activity
KV188_07430	COG0431	NADPH-dependent FMN reductase
KV188_07435	COG2259	Doxx family
KV188_07440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KV188_07445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KV188_07450	COG0697	spore germination
KV188_07455	COG4783	chaperone-mediated protein folding
KV188_07465	COG1040	competence protein
KV188_07480	COG0456	acetyltransferase
KV188_07485	COG0513	Belongs to the DEAD box helicase family
KV188_07490	COG0259	pyridoxamine-phosphate oxidase activity
KV188_07495	COG0747	negative chemotaxis
KV188_07505	COG1584	GPR1 FUN34 yaaH family protein
KV188_07510	COG1120	ATPase activity
KV188_07515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KV188_07520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KV188_07545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KV188_07550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KV188_07575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KV188_07595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KV188_07595	COG0140	phosphoribosyl-ATP diphosphatase activity
KV188_07600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KV188_07605	COG0024	Methionine aminopeptidase
KV188_07620	COG1621	beta-fructofuranosidase activity
KV188_07625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KV188_07635	COG4591	ABC-type transport system involved in lipoprotein release permease component
KV188_07640	COG1136	(ABC) transporter
KV188_07645	COG4591	ABC-type transport system involved in lipoprotein release permease component
KV188_07650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KV188_07680	COG2897	thiosulfate sulfurtransferase activity
KV188_07685	COG2391	methyltransferase activity
KV188_07690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KV188_07695	COG0592	DNA-directed DNA polymerase activity
KV188_07710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KV188_07725	COG0616	signal peptide processing
KV188_07730	COG2001	Belongs to the MraZ family
KV188_07740	COG3116	cell division
KV188_07745	COG0768	penicillin binding
KV188_07750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KV188_07755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KV188_07765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KV188_07770	COG0772	Belongs to the SEDS family
KV188_07780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KV188_07785	COG1181	Belongs to the D-alanine--D-alanine ligase family
KV188_07795	COG0849	cell division
KV188_07800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KV188_07810	COG0497	DNA recombination
KV188_07815	COG4172	Belongs to the ABC transporter superfamily
KV188_07820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KV188_07825	COG0601	transmembrane transport
KV188_07855	COG0012	GTP binding
KV188_07860	COG2020	methyltransferase activity
KV188_07870	COG3133	Outer membrane lipoprotein
KV188_07875	COG3102	Protein conserved in bacteria
KV188_07880	COG0018	arginyl-trna synthetase
KV188_07895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KV188_07900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KV188_07905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KV188_07910	COG0196	riboflavin kinase activity
KV188_07915	COG3172	ATPase kinase involved in NAD metabolism
KV188_07920	COG2129	metallophosphoesterase
KV188_07925	COG0745	RESPONSE REGULATOR receiver
KV188_07935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KV188_07940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KV188_07945	COG1217	gtp-binding protein TYPA
KV188_07950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KV188_07955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KV188_07960	COG1561	YicC-like family, N-terminal region
KV188_07965	COG0354	folic acid binding
KV188_07970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KV188_07975	COG2197	response regulator
KV188_07985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KV188_08025	COG0747	negative chemotaxis
KV188_08030	COG0747	negative chemotaxis
KV188_08035	COG0601	transmembrane transport
KV188_08040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KV188_08045	COG0444	Belongs to the ABC transporter superfamily
KV188_08050	COG4608	Belongs to the ABC transporter superfamily
KV188_08065	COG0251	oxidation-reduction process
KV188_08070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KV188_08075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KV188_08080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KV188_08085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KV188_08090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KV188_08095	COG0848	biopolymer transport protein
KV188_08100	COG0811	peptide transport
KV188_08105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KV188_08110	COG3118	belongs to the thioredoxin family
KV188_08115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KV188_08115	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KV188_08115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV188_08120	COG1461	Dihydroxyacetone kinase
KV188_08125	COG2376	Dihydroxyacetone kinase
KV188_08130	COG0492	ferredoxin-NADP+ reductase activity
KV188_08135	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KV188_08140	COG3753	Protein conserved in bacteria
KV188_08160	COG3030	protein affecting phage T7 exclusion by the F plasmid
KV188_08165	COG0006	proline dipeptidase activity
KV188_08175	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
KV188_08200	COG3978	acetolactate synthase activity
KV188_08215	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KV188_08220	COG0437	4 iron, 4 sulfur cluster binding
KV188_08225	COG3301	Polysulphide reductase, NrfD
KV188_08250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KV188_08255	COG1414	Transcriptional regulator
KV188_08260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KV188_08270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KV188_08280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KV188_08285	COG3068	Protein conserved in bacteria
KV188_08310	COG1278	Cold shock
KV188_08315	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KV188_08320	COG0793	Belongs to the peptidase S41A family
KV188_08325	COG2989	Protein conserved in bacteria
KV188_08330	COG3108	Peptidase M15
KV188_08335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KV188_08350	COG0537	adenosine 5'-monophosphoramidase activity
KV188_08355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KV188_08360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KV188_08370	COG1162	GTPase activity
KV188_08375	COG0583	DNA-binding transcription factor activity
KV188_08380	COG1011	Hydrolase
KV188_08385	COG0583	DNA-binding transcription factor activity
KV188_08395	COG0252	asparaginase activity
KV188_08405	COG5413	integral membrane protein
KV188_08420	COG3835	regulator
KV188_08425	COG2610	gluconate transmembrane transporter activity
KV188_08430	COG1929	Belongs to the glycerate kinase type-1 family
KV188_08435	COG1254	Belongs to the acylphosphatase family
KV188_08440	COG3593	DNA synthesis involved in DNA repair
KV188_08445	COG1611	Belongs to the LOG family
KV188_08450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KV188_08460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KV188_08465	COG0316	Belongs to the HesB IscA family
KV188_08465	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KV188_08470	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KV188_08475	COG1805	sodium ion transport
KV188_08480	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KV188_08485	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KV188_08490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KV188_08495	COG2871	sodium ion transport
KV188_08500	COG1477	protein flavinylation
KV188_08505	COG2991	Protein conserved in bacteria
KV188_08515	COG2814	Major facilitator Superfamily
KV188_08520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KV188_08530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KV188_08545	COG4657	Part of a membrane complex involved in electron transport
KV188_08550	COG2878	Part of a membrane complex involved in electron transport
KV188_08555	COG4656	Part of a membrane complex involved in electron transport
KV188_08580	COG1560	Kdo2-lipid A biosynthetic process
KV188_08585	COG0402	S-adenosylhomocysteine deaminase activity
KV188_08590	COG4143	(ABC) transporter
KV188_08595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KV188_08600	COG0617	tRNA 3'-terminal CCA addition
KV188_08605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KV188_08615	COG2911	Protein conserved in bacteria
KV188_08625	COG0346	lactoylglutathione lyase activity
KV188_08630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KV188_08640	COG1605	Chorismate mutase
KV188_08640	COG0287	Prephenate dehydrogenase
KV188_08645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KV188_08650	COG0859	PFAM glycosyl transferase family 9
KV188_08655	COG0469	pyruvate kinase activity
KV188_08660	COG2062	phosphohistidine phosphatase, SixA
KV188_08665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KV188_08670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KV188_08675	COG0733	neurotransmitter:sodium symporter activity
KV188_08680	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KV188_08685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KV188_08690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KV188_08695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KV188_08700	COG4972	Pilus assembly protein
KV188_08720	COG4796	Type ii and iii secretion system protein
KV188_08725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KV188_08730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KV188_08735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KV188_08740	COG1280	lysine exporter protein (LysE YggA)
KV188_08745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KV188_08755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KV188_08770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KV188_08825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KV188_08830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KV188_08835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KV188_08850	COG1253	flavin adenine dinucleotide binding
KV188_08855	COG0564	pseudouridine synthase activity
KV188_08860	COG0588	phosphoglycerate mutase activity
KV188_08865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KV188_08870	COG1678	Uncharacterized ACR, COG1678
KV188_08875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KV188_08885	COG0271	Belongs to the BolA IbaG family
KV188_08920	COG0494	nUDIX hydrolase
KV188_08925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KV188_08935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KV188_08950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KV188_08955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KV188_08960	COG0083	homoserine kinase activity
KV188_08965	COG0460	homoserine dehydrogenase
KV188_08965	COG0527	aspartate kinase activity
KV188_08970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KV188_08975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KV188_08980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KV188_09005	COG2195	Cleaves the N-terminal amino acid of tripeptides
KV188_09010	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KV188_09015	COG0194	GDP metabolic process
KV188_09020	COG1538	Outer membrane efflux protein
KV188_09025	COG2914	Belongs to the UPF0125 (RnfH) family
KV188_09030	COG2867	negative regulation of translational initiation
KV188_09035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KV188_09040	COG4149	molybdate abc transporter
KV188_09045	COG0725	ABC transporter, periplasmic molybdate-binding protein
KV188_09050	COG0842	Transport permease protein
KV188_09055	COG1131	(ABC) transporter
KV188_09060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KV188_09065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KV188_09070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KV188_09080	COG0251	oxidation-reduction process
KV188_09085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KV188_09090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KV188_09095	COG1121	(ABC) transporter
KV188_09105	COG2920	part of a sulfur-relay system
KV188_09110	COG0670	Belongs to the BI1 family
KV188_09115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KV188_09125	COG0322	excinuclease ABC activity
KV188_09130	COG0084	hydrolase, TatD family'
KV188_09135	COG0210	DNA helicase
KV188_09140	COG3842	ATPase activity
KV188_09145	COG1176	ABC-type spermidine putrescine transport system, permease component I
KV188_09150	COG1177	transmembrane transport
KV188_09155	COG0632	four-way junction helicase activity
KV188_09160	COG2255	four-way junction helicase activity
KV188_09165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KV188_09170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KV188_09210	COG0488	(ABC) transporter
KV188_09215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KV188_09225	COG1271	oxidase subunit
KV188_09230	COG1294	oxidase, subunit
KV188_09245	COG0824	Thioesterase
KV188_09250	COG0811	peptide transport
KV188_09255	COG0848	biopolymer transport protein
KV188_09260	COG3064	Membrane
KV188_09260	COG3064	Membrane
KV188_09265	COG0823	Involved in the tonB-independent uptake of proteins
KV188_09280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KV188_09285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KV188_09295	COG0488	(ABC) transporter
KV188_09305	COG0303	'Molybdopterin
KV188_09310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KV188_09320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KV188_09325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KV188_09335	COG0564	pseudouridine synthase activity
KV188_09340	COG3023	N-Acetylmuramoyl-L-alanine amidase
KV188_09345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KV188_09350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KV188_09355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KV188_09360	COG0626	cystathionine gamma-synthase activity
KV188_09365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KV188_09380	COG1702	phosphate starvation-inducible protein PhoH
KV188_09405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KV188_09425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KV188_09430	COG1660	Displays ATPase and GTPase activities
KV188_09435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV188_09440	COG1137	ATPase activity
KV188_09445	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KV188_09455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KV188_09460	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KV188_09470	COG1704	LemA family
KV188_09475	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KV188_09475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV188_09475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KV188_09480	COG1105	Belongs to the carbohydrate kinase PfkB family
KV188_09485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV188_09485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KV188_09495	COG1523	belongs to the glycosyl hydrolase 13 family
KV188_09505	COG0297	glycogen (starch) synthase activity
KV188_09510	COG0058	SHG alpha-glucan phosphorylase activity
KV188_09535	COG1187	pseudouridine synthase activity
KV188_09540	COG2814	Major facilitator Superfamily
KV188_09550	COG3381	protein complex oligomerization
KV188_09560	COG0791	NLP P60 protein
KV188_09565	COG2932	Transcriptional regulator
KV188_09570	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
KV188_09575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KV188_09580	COG2990	Protein conserved in bacteria
KV188_09590	COG1643	Atp-dependent helicase
KV188_09595	COG2707	UPF0756 membrane protein
KV188_09600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KV188_09605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KV188_09610	COG0534	Mate efflux family protein
KV188_09615	COG1074	ATP-dependent DNA helicase activity
KV188_09620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KV188_09625	COG4535	Mg2 and Co2 transporter CorC
KV188_09635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KV188_09640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KV188_09645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KV188_09650	COG2271	Major facilitator Superfamily
KV188_09655	COG0584	glycerophosphoryl diester phosphodiesterase
KV188_09660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KV188_09665	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KV188_09670	COG0247	lactate metabolic process
KV188_09700	COG0517	IMP dehydrogenase activity
KV188_09700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KV188_09710	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KV188_09715	COG0385	Bile acid
KV188_09720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KV188_09725	COG0561	phosphatase activity
KV188_09735	COG1595	DNA-templated transcription, initiation
KV188_09740	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
KV188_09745	COG3086	response to oxidative stress
KV188_09750	COG0318	PFAM AMP-dependent synthetase and ligase
KV188_09755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KV188_09760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KV188_09765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KV188_09770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KV188_09775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KV188_09775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KV188_09780	COG1160	GTP binding
KV188_09790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KV188_09805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KV188_09810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KV188_09815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KV188_09830	COG0750	zinc metalloprotease
KV188_09835	COG0575	Belongs to the CDS family
KV188_09840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KV188_09845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KV188_09855	COG0671	phosphoesterase, PA-phosphatase related
KV188_09860	COG1534	Rna-binding protein
KV188_09865	COG0463	Glycosyl transferase, family 2
KV188_09870	COG1686	Belongs to the peptidase S11 family
KV188_09875	COG0859	PFAM glycosyl transferase family 9
KV188_09885	COG0328	RNA-DNA hybrid ribonuclease activity
KV188_09890	COG1286	toxin biosynthetic process
KV188_09895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KV188_09905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KV188_09910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KV188_09920	COG0251	oxidation-reduction process
KV188_09925	COG1496	oxidoreductase activity
KV188_09935	COG5645	(Lipo)protein
KV188_09950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KV188_09960	COG1792	Involved in formation and maintenance of cell shape
KV188_09965	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KV188_09970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KV188_09975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KV188_09980	COG0121	glutamine amidotransferase
KV188_09985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KV188_09990	COG2949	membrane
KV188_10005	COG1556	Lactate utilization protein
KV188_10010	COG1139	Iron-sulfur cluster binding protein
KV188_10015	COG0247	lactate metabolic process
KV188_10020	COG1620	l-lactate permease
KV188_10025	COG2916	Histone family protein nucleoid-structuring protein H-NS
KV188_10030	COG1757	Na H antiporter
KV188_10035	COG1879	ABC-type sugar transport system periplasmic component
KV188_10040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KV188_10050	COG2990	Protein conserved in bacteria
KV188_10055	COG0508	dehydrogenase complex catalyzes the overall conversion of
KV188_10060	COG0567	Dehydrogenase, E1 component
KV188_10065	COG1121	(ABC) transporter
KV188_10070	COG0739	heme binding
KV188_10075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KV188_10080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KV188_10090	COG0561	phosphatase activity
KV188_10095	COG3850	Histidine kinase
KV188_10105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KV188_10115	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KV188_10125	COG4221	oxidoreductase activity
KV188_10130	COG0133	tryptophan synthase activity
KV188_10145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KV188_10145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KV188_10150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KV188_10160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KV188_10165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KV188_10190	COG0640	Transcriptional regulator
KV188_10200	COG0189	ligase activity
KV188_10205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KV188_10210	COG0280	phosphate acetyltransferase
KV188_10210	COG0281	malic enzyme
KV188_10215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KV188_10345	COG0305	Participates in initiation and elongation during chromosome replication
KV188_10400	COG0556	nucleotide-excision repair
KV188_10415	COG3179	chitinase
KV188_10425	COG3728	DNA packaging
KV188_10555	COG3683	transport system, periplasmic component
KV188_10560	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
KV188_10565	COG1115	amino acid carrier protein
KV188_10570	COG1116	anion transmembrane transporter activity
KV188_10575	COG1116	anion transmembrane transporter activity
KV188_10580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KV188_10585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KV188_10590	COG2022	thiamine diphosphate biosynthetic process
KV188_10600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KV188_10605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KV188_10615	COG0351	phosphomethylpyrimidine kinase
KV188_10620	COG0351	phosphomethylpyrimidine kinase
KV188_10630	COG0481	GTPase activity
KV188_10635	COG0681	Belongs to the peptidase S26 family
KV188_10640	COG0571	ribonuclease III activity
KV188_10645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KV188_10730	COG1840	ABC-type Fe3 transport system, periplasmic component
KV188_10740	COG4774	siderophore transport
KV188_10760	COG2194	sulfuric ester hydrolase activity
KV188_10765	COG0528	UMP kinase activity
KV188_10770	COG0233	cytoplasmic translational termination
KV188_10775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KV188_10780	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KV188_10790	COG0590	tRNA wobble adenosine to inosine editing
KV188_10795	COG0513	Belongs to the DEAD box helicase family
KV188_10800	COG4785	May be involved in cell division
KV188_10805	COG1185	polyribonucleotide nucleotidyltransferase activity
KV188_10810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KV188_10820	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KV188_10825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KV188_10835	COG3083	sulfuric ester hydrolase activity
KV188_10845	COG1309	transcriptional regulator
KV188_10850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KV188_10855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KV188_10860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KV188_10870	COG3955	Domain of unknown function (DUF1919)
KV188_10875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KV188_10890	COG0516	GMP reductase activity
KV188_10890	COG0517	IMP dehydrogenase activity
KV188_10895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KV188_10900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KV188_10905	COG0814	amino acid
KV188_10910	COG0814	amino acid
KV188_10920	COG3105	Protein conserved in bacteria
KV188_10925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KV188_10935	COG3022	response to hydroperoxide
KV188_10950	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KV188_10955	COG1823	symporter activity
KV188_10965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KV188_10970	COG0072	phenylalanine-tRNA ligase activity
KV188_10975	COG0776	regulation of translation
KV188_10980	COG0791	NLP P60 protein
KV188_10990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KV188_10995	COG1846	Transcriptional regulator
KV188_10995	COG1940	carbohydrate kinase activity
KV188_11000	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KV188_11005	COG1522	sequence-specific DNA binding
KV188_11010	COG1674	ftsk spoiiie
KV188_11015	COG2321	neutral zinc metallopeptidase
KV188_11020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KV188_11025	COG1214	PFAM Peptidase M22, glycoprotease
KV188_11030	COG1435	thymidine kinase activity
KV188_11035	COG3074	FtsZ-dependent cytokinesis
KV188_11040	COG1494	fructose-1,6-bisphosphatase
KV188_11045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KV188_11050	COG0577	efflux transmembrane transporter activity
KV188_11050	COG1136	(ABC) transporter
KV188_11055	COG2205	protein histidine kinase activity
KV188_11060	COG0745	RESPONSE REGULATOR receiver
KV188_11065	COG3956	TIGRFAM MazG family protein
KV188_11075	COG0285	dihydrofolate synthase activity
KV188_11085	COG0779	Required for maturation of 30S ribosomal subunits
KV188_11090	COG0195	Participates in both transcription termination and antitermination
KV188_11095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KV188_11100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KV188_11105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KV188_11110	COG2951	lytic endotransglycosylase activity
KV188_11120	COG0280	phosphate acetyltransferase
KV188_11120	COG0857	belongs to the CobB CobQ family
KV188_11130	COG0737	Belongs to the 5'-nucleotidase family