locus-tag	class	description
L0F67_00005	COG0129	dihydroxy-acid dehydratase activity
L0F67_00015	COG0537	adenosine 5'-monophosphoramidase activity
L0F67_00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L0F67_00035	COG3108	Peptidase M15
L0F67_00045	COG0793	Belongs to the peptidase S41A family
L0F67_00080	COG3068	Protein conserved in bacteria
L0F67_00095	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
L0F67_00105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L0F67_00110	COG1414	Transcriptional regulator
L0F67_00115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L0F67_00165	COG3210	domain, Protein
L0F67_00175	COG3210	domain, Protein
L0F67_00180	COG2831	hemolysin activation secretion protein
L0F67_00200	COG3301	Polysulphide reductase, NrfD
L0F67_00210	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L0F67_00220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L0F67_00230	COG3978	acetolactate synthase activity
L0F67_00235	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L0F67_00240	COG0129	dihydroxy-acid dehydratase activity
L0F67_00260	COG3306	glycosyltransferase involved in LPS biosynthesis
L0F67_00265	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
L0F67_00275	COG0006	proline dipeptidase activity
L0F67_00280	COG3030	protein affecting phage T7 exclusion by the F plasmid
L0F67_00300	COG3753	Protein conserved in bacteria
L0F67_00305	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L0F67_00310	COG0492	ferredoxin-NADP+ reductase activity
L0F67_00320	COG1461	Dihydroxyacetone kinase
L0F67_00325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L0F67_00325	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
L0F67_00325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0F67_00330	COG3118	belongs to the thioredoxin family
L0F67_00340	COG0811	peptide transport
L0F67_00345	COG0848	biopolymer transport protein
L0F67_00350	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L0F67_00355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L0F67_00360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L0F67_00365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L0F67_00370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L0F67_00375	COG0251	oxidation-reduction process
L0F67_00385	COG4608	Belongs to the ABC transporter superfamily
L0F67_00400	COG0601	transmembrane transport
L0F67_00405	COG0747	negative chemotaxis
L0F67_00410	COG0747	negative chemotaxis
L0F67_00445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L0F67_00455	COG2197	response regulator
L0F67_00460	COG0366	Alpha amylase catalytic
L0F67_00470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L0F67_00475	COG0354	folic acid binding
L0F67_00480	COG1561	YicC-like family, N-terminal region
L0F67_00490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L0F67_00510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L0F67_00515	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L0F67_00525	COG0745	RESPONSE REGULATOR receiver
L0F67_00530	COG2129	metallophosphoesterase
L0F67_00535	COG3172	ATPase kinase involved in NAD metabolism
L0F67_00540	COG0196	riboflavin kinase activity
L0F67_00545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L0F67_00555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L0F67_00575	COG3102	Protein conserved in bacteria
L0F67_00580	COG3133	Outer membrane lipoprotein
L0F67_00630	COG0601	transmembrane transport
L0F67_00640	COG4172	Belongs to the ABC transporter superfamily
L0F67_00645	COG0497	DNA recombination
L0F67_00655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L0F67_00680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L0F67_00685	COG0772	Belongs to the SEDS family
L0F67_00690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L0F67_00700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L0F67_00705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L0F67_00715	COG3116	cell division
L0F67_00720	COG0275	rRNA processing
L0F67_00735	COG3700	Belongs to the class B bacterial acid phosphatase family
L0F67_00745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L0F67_00750	COG0549	Belongs to the carbamate kinase family
L0F67_00760	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L0F67_00765	COG1178	ABC-type Fe3 transport system permease component
L0F67_00770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0F67_00775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L0F67_00780	COG2190	(PTS) system
L0F67_00790	COG3059	membrane
L0F67_00800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L0F67_00805	COG1621	beta-fructofuranosidase activity
L0F67_00850	COG2391	methyltransferase activity
L0F67_00855	COG0425	Belongs to the sulfur carrier protein TusA family
L0F67_00880	COG0308	aminopeptidase N
L0F67_00900	COG0805	protein transport
L0F67_00905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L0F67_00910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L0F67_00915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L0F67_00925	COG2226	methyltransferase
L0F67_00930	COG0598	Magnesium transport protein CorA
L0F67_00950	COG3085	chromosome segregation
L0F67_00955	COG0076	glutamate decarboxylase activity
L0F67_00960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L0F67_00970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L0F67_00975	COG2003	Belongs to the UPF0758 family
L0F67_00980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L0F67_00990	COG1309	transcriptional regulator
L0F67_01005	COG1694	Mazg nucleotide pyrophosphohydrolase
L0F67_01010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L0F67_01015	COG1923	regulation of RNA biosynthetic process
L0F67_01050	COG4771	TonB-dependent receptor
L0F67_01050	COG1629	transport
L0F67_01080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L0F67_01105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L0F67_01110	COG0174	glutamine synthetase
L0F67_01120	COG0594	ribonuclease P activity
L0F67_01125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L0F67_01135	COG2818	Glycosylase
L0F67_01145	COG4942	peptidase
L0F67_01145	COG1388	LysM domain
L0F67_01160	COG1238	metal cluster binding
L0F67_01165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L0F67_01175	COG0149	triose-phosphate isomerase activity
L0F67_01195	COG1649	PFAM Uncharacterised BCR, COG1649
L0F67_01195	COG0726	polysaccharide deacetylase
L0F67_01210	COG1022	Amp-dependent synthetase and ligase
L0F67_01220	COG0676	glucose-6-phosphate 1-epimerase activity
L0F67_01225	COG2853	Lipoprotein
L0F67_01235	COG3924	membrane
L0F67_01240	COG4145	pantothenate transmembrane transporter activity
L0F67_01280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L0F67_01335	COG2995	paraquat-inducible protein a
L0F67_01340	COG1305	Transglutaminase-like
L0F67_01350	COG2608	mercury ion transmembrane transporter activity
L0F67_01355	COG1012	belongs to the aldehyde dehydrogenase family
L0F67_01380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L0F67_01415	COG1373	ATPase (AAA superfamily
L0F67_01450	COG2315	Protein conserved in bacteria
L0F67_01455	COG1764	response to oxidative stress
L0F67_01465	COG1902	pentaerythritol trinitrate reductase activity
L0F67_01470	COG0640	Transcriptional regulator
L0F67_01500	COG0778	Nitroreductase
L0F67_01520	COG1902	pentaerythritol trinitrate reductase activity
L0F67_01525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L0F67_01535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L0F67_01545	COG0511	ligase activity, forming carbon-carbon bonds
L0F67_01550	COG0439	Biotin carboxylase
L0F67_01555	COG1763	Mo-molybdopterin cofactor biosynthetic process
L0F67_01565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L0F67_01575	COG0742	ribosomal rna small subunit methyltransferase
L0F67_01580	COG1876	peptidase activity
L0F67_01590	COG1393	Belongs to the ArsC family
L0F67_01600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L0F67_01605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L0F67_01625	COG0564	pseudouridine synthase activity
L0F67_01630	COG0668	transmembrane transport
L0F67_01655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L0F67_01695	COG0180	Tryptophanyl-tRNA synthetase
L0F67_01715	COG1067	ATP-dependent peptidase activity
L0F67_01720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L0F67_01730	COG4795	General secretion pathway protein
L0F67_01750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L0F67_01775	COG1070	Carbohydrate kinase
L0F67_01790	COG1129	ABC transporter
L0F67_01795	COG4214	carbohydrate transport
L0F67_01800	COG2211	Major facilitator Superfamily
L0F67_01815	COG2207	Transcriptional regulator
L0F67_01815	COG1609	Transcriptional regulator
L0F67_01840	COG1442	glycosyl transferase family 8
L0F67_01840	COG1216	Glycosyl transferase, family 2
L0F67_01885	COG3161	chorismate lyase activity
L0F67_01890	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
L0F67_01895	COG1522	sequence-specific DNA binding
L0F67_01900	COG2502	aspartate--ammonia ligase
L0F67_01910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L0F67_01915	COG1595	DNA-templated transcription, initiation
L0F67_01935	COG1263	PTS System
L0F67_01935	COG2190	(PTS) system
L0F67_01935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0F67_01940	COG2190	(PTS) system
L0F67_01940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0F67_01940	COG1263	PTS System
L0F67_01955	COG2723	6-phospho-beta-galactosidase activity
L0F67_01960	COG3711	transcriptional antiterminator
L0F67_01980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L0F67_01985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L0F67_01990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L0F67_01995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L0F67_02000	COG0254	rRNA binding
L0F67_02005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L0F67_02030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L0F67_02035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L0F67_02040	COG0470	DNA polymerase III
L0F67_02050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L0F67_02070	COG0084	hydrolase, TatD family'
L0F67_02080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0F67_02085	COG1215	transferase activity, transferring glycosyl groups
L0F67_02090	COG2832	Protein of unknown function (DUF454)
L0F67_02105	COG4106	trans-aconitate 2-methyltransferase activity
L0F67_02120	COG4804	nuclease activity
L0F67_02160	COG3794	PFAM blue (type 1) copper domain protein
L0F67_02170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L0F67_02175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L0F67_02185	COG0335	large ribosomal subunit rRNA binding
L0F67_02190	COG0336	Belongs to the RNA methyltransferase TrmD family
L0F67_02195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L0F67_02200	COG0228	four-way junction DNA binding
L0F67_02210	COG0202	RNA polymerase activity
L0F67_02215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L0F67_02220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L0F67_02225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L0F67_02240	COG0200	Binds to the 23S rRNA
L0F67_02245	COG1841	ribosomal large subunit assembly
L0F67_02250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L0F67_02255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L0F67_02260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L0F67_02265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L0F67_02270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L0F67_02275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L0F67_02280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L0F67_02290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L0F67_02295	COG0255	Belongs to the universal ribosomal protein uL29 family
L0F67_02300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L0F67_02305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L0F67_02310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L0F67_02315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L0F67_02320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L0F67_02325	COG0089	rRNA binding
L0F67_02330	COG0088	Forms part of the polypeptide exit tunnel
L0F67_02335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L0F67_02340	COG0051	transcription antitermination factor activity, RNA binding
L0F67_02345	COG3070	regulator of competence-specific genes
L0F67_02350	COG0268	Binds directly to 16S ribosomal RNA
L0F67_02385	COG0569	domain protein
L0F67_02395	COG2264	protein methyltransferase activity
L0F67_02415	COG0037	tRNA processing
L0F67_02420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L0F67_02435	COG0825	malonyl-CoA metabolic process
L0F67_02455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L0F67_02485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L0F67_02500	COG0521	Mo-molybdopterin cofactor biosynthetic process
L0F67_02510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L0F67_02520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L0F67_02545	COG0778	Nitroreductase
L0F67_02550	COG1064	alcohol dehydrogenase
L0F67_02595	COG0475	glutathione-regulated potassium exporter activity
L0F67_02595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L0F67_02605	COG1879	ABC-type sugar transport system periplasmic component
L0F67_02615	COG4211	Belongs to the binding-protein-dependent transport system permease family
L0F67_02620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L0F67_02645	COG0656	L-ascorbic acid biosynthetic process
L0F67_02655	COG0673	inositol 2-dehydrogenase activity
L0F67_02660	COG1073	alpha beta
L0F67_02680	COG0702	epimerase
L0F67_02705	COG2814	Major facilitator Superfamily
L0F67_02710	COG0583	DNA-binding transcription factor activity
L0F67_02715	COG1304	FMN binding
L0F67_02740	COG1289	transmembrane transporter activity
L0F67_02745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L0F67_02790	COG4206	TonB-dependent receptor
L0F67_02790	COG1629	transport
L0F67_02795	COG4558	Periplasmic binding protein
L0F67_02805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L0F67_02810	COG3477	response to acidic pH
L0F67_02815	COG0765	amino acid transport
L0F67_02825	COG1126	abc transporter atp-binding protein
L0F67_02830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0F67_02850	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
L0F67_02875	COG3623	hexulose-6-phosphate isomerase
L0F67_02880	COG0235	Class ii aldolase
L0F67_02885	COG0425	Belongs to the sulfur carrier protein TusA family
L0F67_02890	COG2391	methyltransferase activity
L0F67_02895	COG0545	Peptidyl-prolyl cis-trans isomerase
L0F67_02905	COG3681	Belongs to the UPF0597 family
L0F67_02930	COG0783	Belongs to the Dps family
L0F67_02935	COG0840	transmembrane signaling receptor activity
L0F67_02940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L0F67_02945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L0F67_02970	COG2921	Belongs to the UPF0250 family
L0F67_02975	COG1686	Belongs to the peptidase S11 family
L0F67_02980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L0F67_02985	COG0772	Belongs to the SEDS family
L0F67_02990	COG0768	penicillin binding
L0F67_02995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L0F67_03000	COG0799	negative regulation of ribosome biogenesis
L0F67_03005	COG2944	sequence-specific DNA binding
L0F67_03010	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
L0F67_03020	COG1126	abc transporter atp-binding protein
L0F67_03025	COG0765	amino acid transport
L0F67_03040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L0F67_03045	COG1879	ABC-type sugar transport system periplasmic component
L0F67_03050	COG1172	Belongs to the binding-protein-dependent transport system permease family
L0F67_03060	COG1869	D-ribose catabolic process
L0F67_03070	COG1609	Transcriptional regulator
L0F67_03075	COG3265	gluconokinase activity
L0F67_03085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0F67_03085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0F67_03090	COG3715	PTS system
L0F67_03095	COG3716	PTS system mannose fructose sorbose family IID component
L0F67_03105	COG0561	phosphatase activity
L0F67_03110	COG0445	tRNA wobble uridine modification
L0F67_03115	COG0357	Ribosomal RNA small subunit methyltransferase G
L0F67_03140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L0F67_03145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L0F67_03150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L0F67_03155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L0F67_03185	COG1442	glycosyl transferase family 8
L0F67_03190	COG2168	tRNA wobble position uridine thiolation
L0F67_03200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L0F67_03205	COG2964	Protein conserved in bacteria
L0F67_03210	COG0545	Peptidyl-prolyl cis-trans isomerase
L0F67_03215	COG2900	Belongs to the SlyX family
L0F67_03220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L0F67_03225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L0F67_03235	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
L0F67_03245	COG1349	DNA-binding transcription factor activity
L0F67_03250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L0F67_03255	COG0471	metal ion transport
L0F67_03255	COG0490	domain, Protein
L0F67_03260	COG0471	metal ion transport
L0F67_03260	COG0490	domain, Protein
L0F67_03260	COG0471	metal ion transport
L0F67_03260	COG0490	domain, Protein
L0F67_03270	COG0583	DNA-binding transcription factor activity
L0F67_03275	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
L0F67_03280	COG0310	cobalt ion transport
L0F67_03285	COG0310	cobalt ion transport
L0F67_03290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L0F67_03295	COG1122	ATPase activity
L0F67_03305	COG0831	urea catabolic process
L0F67_03345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L0F67_03350	COG0829	nickel cation binding
L0F67_03365	COG3691	Protein conserved in bacteria
L0F67_03375	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L0F67_03395	COG1297	OPT oligopeptide transporter protein
L0F67_03410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L0F67_03420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L0F67_03425	COG0081	regulation of translation
L0F67_03435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L0F67_03445	COG1028	Short-chain dehydrogenase reductase Sdr
L0F67_03450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L0F67_03465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L0F67_03490	COG1943	Transposase
L0F67_03495	COG1131	(ABC) transporter
L0F67_03500	COG0842	Transport permease protein
L0F67_03545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L0F67_03595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L0F67_03600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L0F67_03605	COG0222	ribosome binding
L0F67_03625	COG0737	Belongs to the 5'-nucleotidase family
L0F67_03640	COG2267	carboxylic ester hydrolase activity
L0F67_03645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L0F67_03670	COG0363	glucosamine-6-phosphate deaminase activity
L0F67_03690	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
L0F67_03695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L0F67_03700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L0F67_03710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L0F67_03715	COG2244	polysaccharide biosynthetic process
L0F67_03720	COG2244	polysaccharide biosynthetic process
L0F67_03745	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L0F67_03800	COG4974	Belongs to the 'phage' integrase family
L0F67_03815	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L0F67_03815	COG2885	chlorophyll binding
L0F67_03830	COG2050	protein possibly involved in aromatic compounds catabolism
L0F67_03845	COG0583	DNA-binding transcription factor activity
L0F67_03860	COG0716	FMN binding
L0F67_03915	COG3545	Serine hydrolase
L0F67_03930	COG0625	glutathione transferase activity
L0F67_03935	COG0019	diaminopimelate decarboxylase activity
L0F67_03980	COG1215	transferase activity, transferring glycosyl groups
L0F67_03980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L0F67_04010	COG1119	ATPase activity
L0F67_04025	COG1739	Uncharacterized protein family UPF0029
L0F67_04030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L0F67_04040	COG1970	mechanosensitive ion channel activity
L0F67_04055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L0F67_04065	COG0346	lactoylglutathione lyase activity
L0F67_04070	COG1194	a g-specific adenine glycosylase
L0F67_04075	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L0F67_04080	COG0741	lytic transglycosylase activity
L0F67_04105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L0F67_04125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L0F67_04130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L0F67_04140	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L0F67_04145	COG1053	succinate dehydrogenase
L0F67_04150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L0F67_04155	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
L0F67_04160	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
L0F67_04165	COG2249	NAD(P)H dehydrogenase (quinone) activity
L0F67_04170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L0F67_04175	COG3062	negative regulation of establishment of protein localization
L0F67_04180	COG0243	molybdopterin cofactor binding
L0F67_04195	COG3043	anaerobic respiration
L0F67_04200	COG3005	denitrification pathway
L0F67_04205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L0F67_04215	COG1902	pentaerythritol trinitrate reductase activity
L0F67_04235	COG2918	glutathione biosynthetic process
L0F67_04235	COG1181	Belongs to the D-alanine--D-alanine ligase family
L0F67_04240	COG0688	phosphatidylethanolamine metabolic process
L0F67_04245	COG1555	photosystem II stabilization
L0F67_04250	COG3266	domain, Protein
L0F67_04250	COG3061	Opacity-associated protein A
L0F67_04260	COG0859	PFAM glycosyl transferase family 9
L0F67_04265	COG0859	PFAM glycosyl transferase family 9
L0F67_04270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L0F67_04275	COG0049	tRNA binding
L0F67_04280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L0F67_04290	COG1575	Belongs to the MenA family. Type 1 subfamily
L0F67_04295	COG4804	nuclease activity
L0F67_04300	COG1720	tRNA m6t6A37 methyltransferase activity
L0F67_04310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L0F67_04335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L0F67_04340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L0F67_04350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L0F67_04355	COG1755	Isoprenylcysteine carboxyl methyltransferase
L0F67_04390	COG2153	protein acetylation
L0F67_04395	COG2927	DNA polymerase III (CHI subunit)
L0F67_04400	COG1652	LysM domain
L0F67_04405	COG0544	peptidyl-prolyl cis-trans isomerase activity
L0F67_04410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L0F67_04415	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L0F67_04420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L0F67_04425	COG1045	serine acetyltransferase
L0F67_04470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L0F67_04475	COG1088	dTDP-glucose 4,6-dehydratase activity
L0F67_04485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L0F67_04500	COG2824	Alkylphosphonate utilization operon protein PhnA
L0F67_04505	COG1858	cytochrome C peroxidase
L0F67_04510	COG1872	DUF167
L0F67_04515	COG0762	integral membrane protein
L0F67_04520	COG3171	Protein conserved in bacteria
L0F67_04525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L0F67_04530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L0F67_04535	COG0416	fatty acid biosynthetic process
L0F67_04540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L0F67_04545	COG1399	metal-binding, possibly nucleic acid-binding protein
L0F67_04550	COG4137	Cytochrome C assembly protein
L0F67_04560	COG0733	neurotransmitter:sodium symporter activity
L0F67_04570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L0F67_04570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0F67_04575	COG3715	PTS system
L0F67_04580	COG3716	PTS system mannose fructose sorbose family IID component
L0F67_04620	COG1840	ABC-type Fe3 transport system, periplasmic component
L0F67_04650	COG0557	exoribonuclease II activity
L0F67_04655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L0F67_04660	COG1309	transcriptional regulator
L0F67_04665	COG0583	DNA-binding transcription factor activity
L0F67_04670	COG0678	peroxiredoxin activity
L0F67_04670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L0F67_04680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L0F67_04700	COG3118	belongs to the thioredoxin family
L0F67_04720	COG0625	glutathione transferase activity
L0F67_04725	COG0625	glutathione transferase activity
L0F67_04745	COG2084	Dehydrogenase
L0F67_04750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L0F67_04760	COG0732	type I restriction modification DNA specificity domain
L0F67_04780	COG3630	sodium ion export across plasma membrane
L0F67_04785	COG0471	metal ion transport
L0F67_04790	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L0F67_04795	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L0F67_04805	COG1793	dna ligase
L0F67_04840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L0F67_04845	COG4133	protoheme IX ABC transporter activity
L0F67_04855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L0F67_04860	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L0F67_04870	COG1138	Cytochrome C-type biogenesis protein
L0F67_04910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L0F67_04915	COG0792	nuclease activity
L0F67_04930	COG3101	peptidyl-lysine hydroxylation
L0F67_04935	COG4232	protein-disulfide reductase activity
L0F67_04945	COG3620	sequence-specific DNA binding
L0F67_04965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L0F67_04970	COG4215	(ABC) transporter
L0F67_04975	COG4160	amino acid transport
L0F67_04985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L0F67_04990	COG3099	Belongs to the UPF0263 family
L0F67_05005	COG2884	Cell division ATP-binding protein ftsE
L0F67_05030	COG4783	chaperone-mediated protein folding
L0F67_05040	COG1040	competence protein
L0F67_05045	COG0583	DNA-binding transcription factor activity
L0F67_05050	COG2813	Specifically methylates the guanine in position
L0F67_05060	COG0456	acetyltransferase
L0F67_05065	COG0513	Belongs to the DEAD box helicase family
L0F67_05075	COG0747	negative chemotaxis
L0F67_05085	COG1584	GPR1 FUN34 yaaH family protein
L0F67_05090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L0F67_05095	COG1120	ATPase activity
L0F67_05110	COG4774	siderophore transport
L0F67_05115	COG4774	siderophore transport
L0F67_05125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L0F67_05135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L0F67_05160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L0F67_05180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L0F67_05180	COG0140	phosphoribosyl-ATP diphosphatase activity
L0F67_05185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L0F67_05190	COG0024	Methionine aminopeptidase
L0F67_05195	COG0210	DNA helicase
L0F67_05215	COG4591	ABC-type transport system involved in lipoprotein release permease component
L0F67_05220	COG1136	(ABC) transporter
L0F67_05225	COG4591	ABC-type transport system involved in lipoprotein release permease component
L0F67_05230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L0F67_05275	COG0592	DNA-directed DNA polymerase activity
L0F67_05280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L0F67_05290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L0F67_05300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0F67_05305	COG0616	signal peptide processing
L0F67_05315	COG1114	Component of the transport system for branched-chain amino acids
L0F67_05320	COG1028	Short-chain dehydrogenase reductase Sdr
L0F67_05325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L0F67_05335	COG0142	geranyltranstransferase activity
L0F67_05340	COG0431	NADPH-dependent FMN reductase
L0F67_05345	COG2259	Doxx family
L0F67_05350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L0F67_05355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L0F67_05370	COG0295	cytidine deaminase activity
L0F67_05380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L0F67_05385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L0F67_05395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L0F67_05405	COG0494	nUDIX hydrolase
L0F67_05415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L0F67_05420	COG0363	glucosamine-6-phosphate deaminase activity
L0F67_05425	COG2814	Major facilitator Superfamily
L0F67_05445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L0F67_05460	COG3115	cell septum assembly
L0F67_05475	COG0489	protein tyrosine kinase activity
L0F67_05475	COG3206	protein involved in exopolysaccharide biosynthesis
L0F67_05485	COG1596	polysaccharide export
L0F67_05490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L0F67_05530	COG2814	Major facilitator Superfamily
L0F67_05560	COG1090	epimerase
L0F67_05565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L0F67_05570	COG1127	ABC transporter
L0F67_05575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L0F67_05580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L0F67_05585	COG2854	intermembrane phospholipid transfer
L0F67_05595	COG5007	Belongs to the BolA IbaG family
L0F67_05640	COG2166	iron-sulfur cluster assembly
L0F67_05660	COG2835	tetraacyldisaccharide 4'-kinase activity
L0F67_05730	COG0582	viral genome integration into host DNA
L0F67_05790	COG1252	NADH dehydrogenase
L0F67_05800	COG3719	Belongs to the RNase T2 family
L0F67_05810	COG0778	Nitroreductase
L0F67_05815	COG0300	oxidoreductase activity
L0F67_05825	COG2217	Heavy metal translocating P-type atpase
L0F67_05835	COG0789	Transcriptional regulator
L0F67_05865	COG0745	RESPONSE REGULATOR receiver
L0F67_05870	COG5002	protein histidine kinase activity
L0F67_05880	COG0471	metal ion transport
L0F67_05885	COG0471	metal ion transport
L0F67_05895	COG0126	phosphoglycerate kinase activity
L0F67_05900	COG0191	fructose-bisphosphate aldolase activity
L0F67_05925	COG0778	Nitroreductase
L0F67_05935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L0F67_05955	COG1966	Carbon starvation protein
L0F67_05960	COG1640	4-alpha-glucanotransferase
L0F67_05980	COG3842	ATPase activity
L0F67_05985	COG4580	involved in the transport of maltose and maltodextrins
L0F67_05995	COG2909	trisaccharide binding
L0F67_06000	COG0058	SHG alpha-glucan phosphorylase activity
L0F67_06010	COG1666	GTP binding
L0F67_06025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L0F67_06035	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L0F67_06040	COG2252	PERMEase
L0F67_06045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L0F67_06050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L0F67_06060	COG0716	FMN binding
L0F67_06065	COG0735	belongs to the Fur family
L0F67_06070	COG3008	intermembrane lipid transfer
L0F67_06075	COG1854	S-ribosylhomocysteine lyase activity
L0F67_06085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L0F67_06095	COG3012	SEC-C Motif Domain Protein
L0F67_06095	COG3318	Belongs to the UPF0149 family
L0F67_06100	COG0673	inositol 2-dehydrogenase activity
L0F67_06105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L0F67_06140	COG1426	Protein conserved in bacteria
L0F67_06145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L0F67_06155	COG2976	Protein conserved in bacteria
L0F67_06160	COG3201	nicotinamide mononucleotide transporter
L0F67_06175	COG2965	DNA replication, synthesis of RNA primer
L0F67_06190	COG2841	Protein conserved in bacteria
L0F67_06195	COG2268	Band 7 protein
L0F67_06200	COG1609	Transcriptional regulator
L0F67_06205	COG2226	methyltransferase
L0F67_06210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L0F67_06215	COG0512	Glutamine amidotransferase of anthranilate synthase
L0F67_06220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L0F67_06225	COG2837	iron assimilation
L0F67_06230	COG0009	L-threonylcarbamoyladenylate synthase
L0F67_06240	COG0583	DNA-binding transcription factor activity
L0F67_06245	COG3266	domain, Protein
L0F67_06260	COG4783	chaperone-mediated protein folding
L0F67_06295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L0F67_06305	COG0217	transcriptional regulatory protein
L0F67_06310	COG0494	nUDIX hydrolase
L0F67_06325	COG0402	S-adenosylhomocysteine deaminase activity
L0F67_06330	COG4143	(ABC) transporter
L0F67_06335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L0F67_06340	COG0617	tRNA 3'-terminal CCA addition
L0F67_06345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L0F67_06355	COG2911	Protein conserved in bacteria
L0F67_06365	COG0346	lactoylglutathione lyase activity
L0F67_06370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L0F67_06380	COG0477	Major facilitator Superfamily
L0F67_06385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L0F67_06400	COG1138	Cytochrome C-type biogenesis protein
L0F67_06405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L0F67_06410	COG4235	cytochrome complex assembly
L0F67_06410	COG3088	subunit of a heme lyase
L0F67_06415	COG4235	cytochrome complex assembly
L0F67_06425	COG0748	coenzyme F420 binding
L0F67_06435	COG1605	Chorismate mutase
L0F67_06435	COG0077	Prephenate dehydratase
L0F67_06455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L0F67_06460	COG1882	Formate acetyltransferase
L0F67_06470	COG1238	metal cluster binding
L0F67_06475	COG0501	Belongs to the peptidase M48B family
L0F67_06485	COG2431	L-lysine efflux transmembrane transporter activity
L0F67_06505	COG2962	Rard protein
L0F67_06515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L0F67_06560	COG1216	Glycosyl transferase, family 2
L0F67_06565	COG1216	Glycosyl transferase, family 2
L0F67_06575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L0F67_06585	COG0813	purine-nucleoside phosphorylase activity
L0F67_06590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L0F67_06600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L0F67_06620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L0F67_06625	COG0083	homoserine kinase activity
L0F67_06630	COG0460	homoserine dehydrogenase
L0F67_06630	COG0527	aspartate kinase activity
L0F67_06640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L0F67_06670	COG2195	Cleaves the N-terminal amino acid of tripeptides
L0F67_06675	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L0F67_06690	COG2914	Belongs to the UPF0125 (RnfH) family
L0F67_06695	COG2867	negative regulation of translational initiation
L0F67_06700	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L0F67_06705	COG4149	molybdate abc transporter
L0F67_06710	COG0725	ABC transporter, periplasmic molybdate-binding protein
L0F67_06715	COG0842	Transport permease protein
L0F67_06730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L0F67_06735	COG1121	(ABC) transporter
L0F67_06745	COG2920	part of a sulfur-relay system
L0F67_06750	COG0670	Belongs to the BI1 family
L0F67_06755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L0F67_06775	COG3118	belongs to the thioredoxin family
L0F67_06785	COG0330	HflC and HflK could
L0F67_06795	COG0301	tRNA thio-modification
L0F67_06795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L0F67_06805	COG0424	maF-like protein
L0F67_06815	COG1528	Iron-storage protein
L0F67_06820	COG1528	Iron-storage protein
L0F67_06825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L0F67_06840	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
L0F67_06850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L0F67_06860	COG0488	(ABC) transporter
L0F67_06875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L0F67_06880	COG1012	belongs to the aldehyde dehydrogenase family
L0F67_06880	COG1454	alcohol dehydrogenase
L0F67_06885	COG0181	hydroxymethylbilane synthase activity
L0F67_06890	COG1587	Uroporphyrinogen-III synthase
L0F67_06895	COG2959	enzyme of heme biosynthesis
L0F67_06900	COG3071	HemY protein
L0F67_06905	COG2354	Protein conserved in bacteria
L0F67_06925	COG2095	MarC family integral membrane protein
L0F67_06930	COG4166	transmembrane transport
L0F67_06950	COG2017	converts alpha-aldose to the beta-anomer
L0F67_06960	COG1085	galactose-1-phosphate uridylyltransferase
L0F67_06970	COG0642	Histidine kinase
L0F67_06975	COG0745	RESPONSE REGULATOR receiver
L0F67_06985	COG3111	PFAM Bacterial OB fold (BOF) protein
L0F67_07000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L0F67_07010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L0F67_07015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L0F67_07020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L0F67_07035	COG1253	flavin adenine dinucleotide binding
L0F67_07040	COG0564	pseudouridine synthase activity
L0F67_07045	COG0588	phosphoglycerate mutase activity
L0F67_07050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L0F67_07055	COG1678	Uncharacterized ACR, COG1678
L0F67_07060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L0F67_07070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0F67_07075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0F67_07080	COG1408	metallophosphoesterase
L0F67_07085	COG0753	catalase activity
L0F67_07100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L0F67_07115	COG1702	phosphate starvation-inducible protein PhoH
L0F67_07125	COG0254	rRNA binding
L0F67_07150	COG0583	DNA-binding transcription factor activity
L0F67_07155	COG0708	Exodeoxyribonuclease III
L0F67_07160	COG2056	Na+-H+ antiporter family
L0F67_07170	COG0037	tRNA processing
L0F67_07175	COG3092	negative regulation of chromosome organization
L0F67_07190	COG1607	acyl-coa hydrolase
L0F67_07195	COG2350	Protein conserved in bacteria
L0F67_07210	COG0786	glutamate:sodium symporter activity
L0F67_07235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L0F67_07240	COG0138	bifunctional purine biosynthesis protein purh
L0F67_07245	COG1444	tRNA N-acetyltransferase activity
L0F67_07260	COG2801	Transposase and inactivated derivatives
L0F67_07280	COG2027	D-alanyl-D-alanine carboxypeptidase
L0F67_07285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L0F67_07305	COG2830	Protein of unknown function (DUF452)
L0F67_07310	COG2226	methyltransferase
L0F67_07325	COG0697	spore germination
L0F67_07330	COG0784	Response regulator, receiver
L0F67_07330	COG2198	Histidine kinase
L0F67_07330	COG5002	protein histidine kinase activity
L0F67_07335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L0F67_07345	COG1959	2 iron, 2 sulfur cluster binding
L0F67_07350	COG1104	cysteine desulfurase activity
L0F67_07365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L0F67_07385	COG0633	Ferredoxin
L0F67_07390	COG2975	iron-sulfur cluster assembly
L0F67_07420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L0F67_07425	COG0215	cysteine-tRNA ligase activity
L0F67_07430	COG2160	L-arabinose isomerase activity
L0F67_07445	COG1172	Belongs to the binding-protein-dependent transport system permease family
L0F67_07460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L0F67_07485	COG0583	DNA-binding transcription factor activity
L0F67_07495	COG0110	maltose O-acetyltransferase activity
L0F67_07505	COG3642	lipopolysaccharide core region biosynthetic process
L0F67_07510	COG0302	gtp cyclohydrolase
L0F67_07520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L0F67_07525	COG1560	Kdo2-lipid A biosynthetic process
L0F67_07530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L0F67_07555	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L0F67_07565	COG1704	LemA family
L0F67_07575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L0F67_07575	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L0F67_07575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L0F67_07580	COG1105	Belongs to the carbohydrate kinase PfkB family
L0F67_07600	COG1523	belongs to the glycosyl hydrolase 13 family
L0F67_07610	COG0297	glycogen (starch) synthase activity
L0F67_07620	COG0105	UTP biosynthetic process
L0F67_07645	COG2814	Major facilitator Superfamily
L0F67_07655	COG3381	protein complex oligomerization
L0F67_07665	COG0791	NLP P60 protein
L0F67_07670	COG2932	Transcriptional regulator
L0F67_07675	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
L0F67_07680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L0F67_07700	COG2707	UPF0756 membrane protein
L0F67_07710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L0F67_07725	COG1396	sequence-specific DNA binding
L0F67_07730	COG3550	peptidyl-serine autophosphorylation
L0F67_07735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L0F67_07740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L0F67_07745	COG1328	CTP reductase activity
L0F67_07750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L0F67_07765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L0F67_07775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0F67_07780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L0F67_07785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L0F67_07800	COG0750	zinc metalloprotease
L0F67_07805	COG0575	Belongs to the CDS family
L0F67_07810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L0F67_07815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L0F67_07825	COG0671	phosphoesterase, PA-phosphatase related
L0F67_07830	COG1534	Rna-binding protein
L0F67_07835	COG0463	Glycosyl transferase, family 2
L0F67_07840	COG1686	Belongs to the peptidase S11 family
L0F67_07845	COG0859	PFAM glycosyl transferase family 9
L0F67_07855	COG0328	RNA-DNA hybrid ribonuclease activity
L0F67_07860	COG1286	toxin biosynthetic process
L0F67_07865	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L0F67_07890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L0F67_07895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L0F67_07905	COG0251	oxidation-reduction process
L0F67_07910	COG1496	oxidoreductase activity
L0F67_07920	COG0582	viral genome integration into host DNA
L0F67_08030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L0F67_08060	COG1403	HNH endonuclease
L0F67_08090	COG3772	lysozyme
L0F67_08120	COG0740	serine-type endopeptidase activity
L0F67_08230	COG0582	viral genome integration into host DNA
L0F67_08265	COG3728	DNA packaging
L0F67_08300	COG5645	(Lipo)protein
L0F67_08325	COG1792	Involved in formation and maintenance of cell shape
L0F67_08330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L0F67_08335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L0F67_08340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L0F67_08360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L0F67_08370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L0F67_08375	COG0045	succinate-CoA ligase (ADP-forming) activity
L0F67_08380	COG2990	Protein conserved in bacteria
L0F67_08385	COG0508	dehydrogenase complex catalyzes the overall conversion of
L0F67_08405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L0F67_08410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L0F67_08425	COG3850	Histidine kinase
L0F67_08440	COG0393	Putative heavy-metal-binding
L0F67_08455	COG4221	oxidoreductase activity
L0F67_08460	COG0133	tryptophan synthase activity
L0F67_08480	COG1380	Effector of murein hydrolase LrgA
L0F67_08485	COG1346	cytolysis
L0F67_08490	COG1132	(ABC) transporter
L0F67_08500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L0F67_08505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L0F67_08510	COG0167	dihydroorotate dehydrogenase activity
L0F67_08520	COG0508	dehydrogenase complex catalyzes the overall conversion of
L0F67_08525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L0F67_08550	COG0737	Belongs to the 5'-nucleotidase family
L0F67_08555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L0F67_08560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L0F67_08590	COG3036	rescue of stalled ribosome
L0F67_08635	COG1802	Transcriptional regulator
L0F67_08635	COG4626	Terminase
L0F67_08685	COG0582	viral genome integration into host DNA
L0F67_08700	COG1346	cytolysis
L0F67_08705	COG1380	Effector of murein hydrolase LrgA
L0F67_08725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L0F67_08730	COG2226	methyltransferase
L0F67_08735	COG0596	Alpha beta hydrolase
L0F67_08740	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
L0F67_08745	COG0318	PFAM AMP-dependent synthetase and ligase
L0F67_08765	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
L0F67_08770	COG1785	Belongs to the alkaline phosphatase family
L0F67_08780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L0F67_08795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L0F67_08800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L0F67_08805	COG0539	negative regulation of cytoplasmic translation
L0F67_08810	COG0776	regulation of translation
L0F67_08815	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
L0F67_08820	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
L0F67_08830	COG0023	Translation Initiation Factor
L0F67_08835	COG3787	Belongs to the UPF0306 family
L0F67_08840	COG1811	Na channel or pump
L0F67_08850	COG3094	Invasion gene expression up-regulator, SirB
L0F67_08865	COG0440	acetolactate synthase activity
L0F67_08880	COG1278	Cold shock
L0F67_08890	COG0343	queuine tRNA-ribosyltransferase activity
L0F67_08895	COG3945	hemerythrin HHE cation binding domain
L0F67_08905	COG4991	sh3 domain protein
L0F67_08910	COG0306	phosphate transporter
L0F67_08915	COG1392	Phosphate transport regulator
L0F67_08920	COG4604	ABC transporter, ATP-binding protein
L0F67_08925	COG4605	iron ion homeostasis
L0F67_08935	COG4607	ABC-type enterochelin transport system periplasmic component
L0F67_08940	COG0305	Participates in initiation and elongation during chromosome replication
L0F67_08945	COG3100	YcgL domain-containing protein
L0F67_08950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L0F67_08955	COG0527	aspartate kinase activity
L0F67_08970	COG2731	YhcH YjgK YiaL family protein
L0F67_08975	COG1737	Transcriptional regulator
L0F67_08980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L0F67_08995	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L0F67_08995	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L0F67_09000	COG0583	DNA-binding transcription factor activity
L0F67_09015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L0F67_09020	COG0314	molybdopterin synthase activity
L0F67_09025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L0F67_09030	COG0315	cyclic pyranopterin monophosphate synthase activity
L0F67_09040	COG3005	denitrification pathway
L0F67_09045	COG0243	molybdopterin cofactor binding
L0F67_09050	COG2363	Small membrane protein
L0F67_09065	COG0626	cystathionine gamma-synthase activity
L0F67_09070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L0F67_09075	COG0741	lytic transglycosylase activity
L0F67_09085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L0F67_09095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L0F67_09105	COG1509	lysine 2,3-aminomutase activity
L0F67_09115	COG2925	Exonuclease
L0F67_09125	COG0613	PHP domain protein
L0F67_09150	COG0556	nucleotide-excision repair
L0F67_09165	COG0006	proline dipeptidase activity
L0F67_09170	COG1448	Aminotransferase
L0F67_09175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L0F67_09185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L0F67_09190	COG0625	glutathione transferase activity
L0F67_09195	COG2969	positive regulation of protein catabolic process
L0F67_09205	COG0589	response to stress
L0F67_09215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L0F67_09230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L0F67_09250	COG0737	Belongs to the 5'-nucleotidase family
L0F67_09275	COG2951	lytic endotransglycosylase activity
L0F67_09285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L0F67_09295	COG0195	Participates in both transcription termination and antitermination
L0F67_09300	COG0779	Required for maturation of 30S ribosomal subunits
L0F67_09310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L0F67_09315	COG1943	Transposase
L0F67_09325	COG0732	type I restriction modification DNA specificity domain
L0F67_09340	COG0285	dihydrofolate synthase activity
L0F67_09350	COG3956	TIGRFAM MazG family protein
L0F67_09355	COG0745	RESPONSE REGULATOR receiver
L0F67_09360	COG2205	protein histidine kinase activity
L0F67_09370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L0F67_09375	COG1494	fructose-1,6-bisphosphatase
L0F67_09380	COG3074	FtsZ-dependent cytokinesis
L0F67_09385	COG1435	thymidine kinase activity
L0F67_09395	COG1214	PFAM Peptidase M22, glycoprotease
L0F67_09400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L0F67_09405	COG2321	neutral zinc metallopeptidase
L0F67_09410	COG1674	ftsk spoiiie
L0F67_09415	COG1522	sequence-specific DNA binding
L0F67_09420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L0F67_09425	COG1940	carbohydrate kinase activity
L0F67_09425	COG1846	Transcriptional regulator
L0F67_09430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L0F67_09440	COG0776	regulation of translation
L0F67_09445	COG0072	phenylalanine-tRNA ligase activity
L0F67_09450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L0F67_09455	COG0778	Nitroreductase
L0F67_09460	COG1823	symporter activity
L0F67_09490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L0F67_09495	COG3105	Protein conserved in bacteria
L0F67_09505	COG0814	amino acid
L0F67_09510	COG0814	amino acid
L0F67_09515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L0F67_09525	COG0516	GMP reductase activity
L0F67_09525	COG0517	IMP dehydrogenase activity
L0F67_09555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L0F67_09560	COG3955	Domain of unknown function (DUF1919)
L0F67_09570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L0F67_09575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L0F67_09585	COG1309	transcriptional regulator
L0F67_09590	COG3082	Protein of unknown function (DUF1414)
L0F67_09595	COG3083	sulfuric ester hydrolase activity
L0F67_09600	COG2828	Protein conserved in bacteria
L0F67_09610	COG2188	Transcriptional regulator
L0F67_09620	COG2814	Major facilitator Superfamily
L0F67_09630	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
L0F67_09645	COG1185	polyribonucleotide nucleotidyltransferase activity
L0F67_09650	COG4785	May be involved in cell division
L0F67_09655	COG0513	Belongs to the DEAD box helicase family
L0F67_09660	COG0590	tRNA wobble adenosine to inosine editing
L0F67_09670	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L0F67_09675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L0F67_09680	COG0233	cytoplasmic translational termination
L0F67_09685	COG0528	UMP kinase activity
L0F67_09705	COG4178	(ABC) transporter
L0F67_09720	COG1840	ABC-type Fe3 transport system, periplasmic component
L0F67_09820	COG0571	ribonuclease III activity
L0F67_09840	COG0351	phosphomethylpyrimidine kinase
L0F67_09860	COG1115	amino acid carrier protein
L0F67_09870	COG3683	transport system, periplasmic component
L0F67_09880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L0F67_09890	COG0471	metal ion transport
L0F67_09895	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
L0F67_09895	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L0F67_09905	COG2301	Belongs to the HpcH HpaI aldolase family
L0F67_09910	COG3052	prosthetic group binding
L0F67_09920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L0F67_09925	COG0189	ligase activity
L0F67_09935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L0F67_09950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0F67_09950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L0F67_09965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L0F67_09970	COG0629	single-stranded DNA binding
L0F67_09980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L0F67_09995	COG0477	Major facilitator Superfamily
L0F67_10000	COG3676	manually curated
L0F67_10010	COG0583	DNA-binding transcription factor activity
L0F67_10020	COG1028	Short-chain dehydrogenase reductase Sdr
L0F67_10020	COG3321	synthase
L0F67_10020	COG0604	alcohol dehydrogenase
L0F67_10045	COG2070	2-Nitropropane dioxygenase
L0F67_10050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L0F67_10065	COG1368	sulfuric ester hydrolase activity
L0F67_10070	COG3217	Mosc domain protein beta barrel domain protein
L0F67_10070	COG0633	Ferredoxin
L0F67_10075	COG1722	exodeoxyribonuclease VII activity
L0F67_10080	COG0142	geranyltranstransferase activity
L0F67_10090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L0F67_10095	COG1530	ribonuclease E activity
L0F67_10100	COG1944	ATP diphosphatase activity
L0F67_10125	COG0500	methyltransferase
L0F67_10135	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
L0F67_10165	COG4172	Belongs to the ABC transporter superfamily
L0F67_10175	COG4168	peptide transport system, permease
L0F67_10190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L0F67_10195	COG1879	ABC-type sugar transport system periplasmic component
L0F67_10200	COG1757	Na H antiporter
L0F67_10205	COG2916	Histone family protein nucleoid-structuring protein H-NS
L0F67_10210	COG1620	l-lactate permease
L0F67_10215	COG0247	lactate metabolic process
L0F67_10225	COG1556	Lactate utilization protein
L0F67_10230	COG2949	membrane
L0F67_10235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L0F67_10255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L0F67_10260	COG1349	DNA-binding transcription factor activity
L0F67_10265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L0F67_10270	COG2915	High frequency lysogenization protein hflD homolog
L0F67_10285	COG4988	ABC transporter
L0F67_10290	COG2911	Protein conserved in bacteria
L0F67_10300	COG2861	carbohydrate metabolic process
L0F67_10315	COG1279	arginine transmembrane transporter activity
L0F67_10320	COG0572	uridine kinase
L0F67_10330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L0F67_10340	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
L0F67_10355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L0F67_10360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L0F67_10365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L0F67_10370	COG4166	transmembrane transport
L0F67_10385	COG4608	Belongs to the ABC transporter superfamily
L0F67_10390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L0F67_10395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L0F67_10400	COG0747	negative chemotaxis
L0F67_10405	COG0814	amino acid
L0F67_10410	COG1760	l-serine dehydratase
L0F67_10420	COG0134	indole-3-glycerol-phosphate synthase activity
L0F67_10420	COG0135	phosphoribosylanthranilate isomerase activity
L0F67_10425	COG3177	Filamentation induced by cAMP protein fic
L0F67_10430	COG3098	single-species biofilm formation
L0F67_10435	COG0564	pseudouridine synthase activity
L0F67_10440	COG3140	Belongs to the UPF0181 family
L0F67_10450	COG3025	triphosphatase activity
L0F67_10455	COG3106	COG3106 Predicted ATPase
L0F67_10460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L0F67_10470	COG3069	C4-dicarboxylate transmembrane transporter activity
L0F67_10475	COG3340	Belongs to the peptidase S51 family
L0F67_10490	COG0495	leucyl-tRNA aminoacylation
L0F67_10495	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
L0F67_10500	COG1466	dna polymerase III delta subunit
L0F67_10505	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L0F67_10510	COG0237	dephospho-CoA kinase activity
L0F67_10520	COG1459	type II secretion system
L0F67_10525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L0F67_10530	COG4969	Belongs to the N-Me-Phe pilin family
L0F67_10575	COG0247	lactate metabolic process
L0F67_10580	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L0F67_10585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L0F67_10615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L0F67_10635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L0F67_10645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L0F67_10645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L0F67_10650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L0F67_10660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L0F67_10665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L0F67_10670	COG0318	PFAM AMP-dependent synthetase and ligase
L0F67_10680	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
L0F67_10685	COG1595	DNA-templated transcription, initiation
L0F67_10695	COG0561	phosphatase activity
L0F67_10700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L0F67_10710	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L0F67_10720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L0F67_10725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L0F67_10735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L0F67_10750	COG5339	Protein conserved in bacteria
L0F67_10760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L0F67_10775	COG2864	formate dehydrogenase
L0F67_10780	COG3058	Necessary for formate dehydrogenase activity
L0F67_10790	COG3117	lipopolysaccharide transmembrane transporter activity
L0F67_10795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L0F67_10800	COG1137	ATPase activity
L0F67_10805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L0F67_10815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L0F67_10835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L0F67_10855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L0F67_10860	COG0631	protein serine/threonine phosphatase activity
L0F67_10880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L0F67_10900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L0F67_10910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L0F67_10915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L0F67_10920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L0F67_10930	COG0564	pseudouridine synthase activity
L0F67_10945	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L0F67_10950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L0F67_10960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L0F67_10965	COG0303	'Molybdopterin
L0F67_10970	COG2095	MarC family integral membrane protein
L0F67_10975	COG0488	(ABC) transporter
L0F67_10990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L0F67_11015	COG3064	Membrane
L0F67_11020	COG0848	biopolymer transport protein
L0F67_11025	COG0811	peptide transport
L0F67_11030	COG0824	Thioesterase
L0F67_11045	COG1294	oxidase, subunit
L0F67_11050	COG1271	oxidase subunit
L0F67_11070	COG0494	nUDIX hydrolase
L0F67_11110	COG0271	Belongs to the BolA IbaG family
L0F67_11140	COG4172	Belongs to the ABC transporter superfamily
L0F67_11145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L0F67_11165	COG1177	transmembrane transport
L0F67_11170	COG1176	ABC-type spermidine putrescine transport system, permease component I
L0F67_11175	COG3842	ATPase activity
L0F67_11195	COG0084	hydrolase, TatD family'
L0F67_11210	COG0531	amino acid
L0F67_11215	COG0531	amino acid
L0F67_11230	COG3047	cAMP biosynthetic process
L0F67_11235	COG0542	response to heat
L0F67_11240	COG0798	PFAM Bile acid sodium symporter
L0F67_11245	COG0659	secondary active sulfate transmembrane transporter activity
L0F67_11250	COG1393	Belongs to the ArsC family
L0F67_11260	COG1027	Aspartate ammonia-lyase
L0F67_11275	COG3851	Histidine kinase
L0F67_11280	COG2197	response regulator
L0F67_11285	COG2271	Major facilitator Superfamily
L0F67_11290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L0F67_11295	COG3064	Membrane
L0F67_11295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L0F67_11295	COG3583	domain protein
L0F67_11305	COG0720	synthase
L0F67_11310	COG0602	queuosine metabolic process
L0F67_11320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L0F67_11330	COG0795	lipopolysaccharide-transporting ATPase activity
L0F67_11335	COG0795	lipopolysaccharide-transporting ATPase activity
L0F67_11370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L0F67_11380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L0F67_11390	COG0861	Integral membrane protein TerC family
L0F67_11400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L0F67_11405	COG0148	phosphopyruvate hydratase activity
L0F67_11410	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
L0F67_11430	COG1965	Belongs to the frataxin family
L0F67_11445	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L0F67_11460	COG0205	6-phosphofructokinase activity
L0F67_11465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L0F67_11475	COG1115	amino acid carrier protein
L0F67_11480	COG0628	permease
L0F67_11490	COG0826	peptidase U32
L0F67_11495	COG3307	-O-antigen
L0F67_11510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L0F67_11520	COG0802	atpase or kinase
L0F67_11535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L0F67_11540	COG2062	phosphohistidine phosphatase, SixA
L0F67_11545	COG0469	pyruvate kinase activity
L0F67_11550	COG0859	PFAM glycosyl transferase family 9
L0F67_11560	COG0287	Prephenate dehydrogenase
L0F67_11560	COG1605	Chorismate mutase
L0F67_11570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L0F67_11590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L0F67_11595	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L0F67_11600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L0F67_11605	COG4796	Type ii and iii secretion system protein
L0F67_11630	COG4972	Pilus assembly protein
L0F67_11635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L0F67_11640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L0F67_11645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L0F67_11655	COG0733	neurotransmitter:sodium symporter activity
L0F67_11665	COG2960	long-chain fatty acid transporting porin activity
L0F67_11690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L0F67_11700	COG0551	DNA topoisomerase type I activity
L0F67_11710	COG2137	regulation of response to DNA damage stimulus
L0F67_11715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L0F67_11720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L0F67_11735	COG0512	Glutamine amidotransferase of anthranilate synthase
L0F67_11745	COG1560	Kdo2-lipid A biosynthetic process
L0F67_11760	COG4658	electron transport chain
L0F67_11780	COG4657	Part of a membrane complex involved in electron transport
L0F67_11790	COG2274	protein secretion by the type I secretion system
L0F67_11810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L0F67_11820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L0F67_11825	COG2814	Major facilitator Superfamily
L0F67_11830	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
L0F67_11840	COG2991	Protein conserved in bacteria
L0F67_11845	COG1477	protein flavinylation
L0F67_11850	COG2871	sodium ion transport
L0F67_11855	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L0F67_11860	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L0F67_11865	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L0F67_11870	COG1805	sodium ion transport
L0F67_11875	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L0F67_11880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L0F67_11880	COG0316	Belongs to the HesB IscA family
L0F67_11885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L0F67_11890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L0F67_11895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L0F67_11905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L0F67_11915	COG3593	DNA synthesis involved in DNA repair
L0F67_11920	COG1254	Belongs to the acylphosphatase family
L0F67_11925	COG1929	Belongs to the glycerate kinase type-1 family
L0F67_11930	COG2610	gluconate transmembrane transporter activity
L0F67_11935	COG3835	regulator
L0F67_11940	COG4166	transmembrane transport
L0F67_11960	COG5413	integral membrane protein
L0F67_11970	COG0252	asparaginase activity
L0F67_11985	COG1011	Hydrolase
L0F67_11990	COG0583	DNA-binding transcription factor activity
L0F67_11995	COG1162	GTPase activity
L0F67_12015	COG0537	adenosine 5'-monophosphoramidase activity
L0F67_12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L0F67_12035	COG3108	Peptidase M15
L0F67_12040	COG2989	Protein conserved in bacteria
L0F67_12080	COG3068	Protein conserved in bacteria
L0F67_12095	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
L0F67_12105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L0F67_12110	COG1414	Transcriptional regulator
L0F67_12115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L0F67_12165	COG3210	domain, Protein
L0F67_12170	COG2831	hemolysin activation secretion protein
L0F67_12190	COG3301	Polysulphide reductase, NrfD
L0F67_12200	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L0F67_12210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L0F67_12220	COG3978	acetolactate synthase activity
L0F67_12225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions