locus-tag	class	description
DLE03_00005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DLE03_00010	COG2177	Part of the ABC transporter FtsEX involved in
DLE03_00015	COG2884	Cell division ATP-binding protein ftsE
DLE03_00020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DLE03_00075	COG0567	Dehydrogenase, E1 component
DLE03_00075	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLE03_00080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DLE03_00105	COG1595	DNA-templated transcription, initiation
DLE03_00110	COG2135	peptidase activity
DLE03_00115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DLE03_00120	COG1162	GTPase activity
DLE03_00125	COG0483	inositol monophosphate 1-phosphatase activity
DLE03_00135	COG1183	phosphatidylcholine synthase activity
DLE03_00150	COG1615	UPF0182 protein
DLE03_00155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DLE03_00205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DLE03_00215	COG0210	DNA helicase
DLE03_00225	COG0012	GTP binding
DLE03_00245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DLE03_00250	COG1570	exodeoxyribonuclease VII activity
DLE03_00255	COG1722	exodeoxyribonuclease VII activity
DLE03_00260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DLE03_00260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DLE03_00270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DLE03_00290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DLE03_00355	COG0148	phosphopyruvate hydratase activity
DLE03_00375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DLE03_00380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DLE03_00385	COG0193	aminoacyl-tRNA hydrolase activity
DLE03_00390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DLE03_00395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DLE03_00400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DLE03_00415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DLE03_00420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DLE03_00425	COG0084	hydrolase, TatD family'
DLE03_00430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLE03_00460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DLE03_00465	COG1960	acyl-CoA dehydrogenase activity
DLE03_00485	COG2409	Drug exporters of the RND superfamily
DLE03_00490	COG0788	formyltetrahydrofolate deformylase activity
DLE03_00510	COG0300	oxidoreductase activity
DLE03_00515	COG0513	Belongs to the DEAD box helicase family
DLE03_00525	COG5002	protein histidine kinase activity
DLE03_00525	COG3447	MASE1 domain protein
DLE03_00525	COG5001	Diguanylate cyclase
DLE03_00540	COG0259	pyridoxamine-phosphate oxidase activity
DLE03_00545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DLE03_00575	COG0459	protein refolding
DLE03_00585	COG0702	epimerase
DLE03_00590	COG1252	NADH dehydrogenase
DLE03_00595	COG0596	Alpha beta hydrolase
DLE03_00610	COG3250	beta-galactosidase activity
DLE03_00625	COG0215	cysteine-tRNA ligase activity
DLE03_00630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DLE03_00630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DLE03_00635	COG1329	Transcriptional regulator
DLE03_00645	COG0588	phosphoglycerate mutase activity
DLE03_00655	COG0438	transferase activity, transferring glycosyl groups
DLE03_00665	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DLE03_00680	COG0735	belongs to the Fur family
DLE03_00705	COG0745	RESPONSE REGULATOR receiver
DLE03_00710	COG0456	acetyltransferase
DLE03_00715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DLE03_00730	COG4702	Belongs to the UPF0303 family
DLE03_00795	COG1216	Glycosyl transferase, family 2
DLE03_00835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE03_00840	COG2755	lipolytic protein G-D-S-L family
DLE03_00840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DLE03_00850	COG0463	Glycosyl transferase, family 2
DLE03_00875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DLE03_00880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DLE03_00885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DLE03_00890	COG3959	Transketolase, thiamine diphosphate binding domain
DLE03_00900	COG0470	DNA polymerase III
DLE03_00905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DLE03_00915	COG1754	DNA topoisomerase type I activity
DLE03_00915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DLE03_00920	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DLE03_00925	COG2723	6-phospho-beta-galactosidase activity
DLE03_00930	COG0395	ABC-type sugar transport system, permease component
DLE03_00935	COG1175	transmembrane transport
DLE03_00940	COG1653	transport
DLE03_00945	COG1609	Transcriptional regulator
DLE03_00950	COG0586	Pfam SNARE associated Golgi protein
DLE03_00955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DLE03_00970	COG0789	Transcriptional regulator
DLE03_00975	COG0484	heat shock protein binding
DLE03_00980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DLE03_00985	COG0443	Heat shock 70 kDa protein
DLE03_00990	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DLE03_00995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DLE03_01000	COG0592	DNA-directed DNA polymerase activity
DLE03_01005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DLE03_01010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DLE03_01015	COG0594	ribonuclease P activity
DLE03_01020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DLE03_01025	COG0706	membrane insertase activity
DLE03_01035	COG0357	Ribosomal RNA small subunit methyltransferase G
DLE03_01040	COG1192	Involved in chromosome partitioning
DLE03_01050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLE03_01055	COG0860	N-Acetylmuramoyl-L-alanine amidase
DLE03_01060	COG3118	belongs to the thioredoxin family
DLE03_01065	COG0492	ferredoxin-NADP+ reductase activity
DLE03_01085	COG0617	tRNA 3'-terminal CCA addition
DLE03_01100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DLE03_01110	COG0360	Binds together with S18 to 16S ribosomal RNA
DLE03_01115	COG0629	single-stranded DNA binding
DLE03_01120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DLE03_01125	COG0359	binds to the 23S rRNA
DLE03_01130	COG0598	Magnesium transport protein CorA
DLE03_01135	COG0305	Participates in initiation and elongation during chromosome replication
DLE03_01145	COG1960	acyl-CoA dehydrogenase activity
DLE03_01150	COG0717	Belongs to the dCTP deaminase family
DLE03_01155	COG1704	LemA family
DLE03_01160	COG0501	Belongs to the peptidase M48B family
DLE03_01165	COG2205	protein histidine kinase activity
DLE03_01170	COG0745	RESPONSE REGULATOR receiver
DLE03_01175	COG0187	DNA topoisomerase II activity
DLE03_01180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DLE03_01205	COG0705	Rhomboid family
DLE03_01205	COG0457	Tetratricopeptide repeat
DLE03_01210	COG0247	lactate metabolic process
DLE03_01210	COG2181	nitrate reductase activity
DLE03_01230	COG0515	serine threonine protein kinase
DLE03_01250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DLE03_01255	COG0561	phosphatase activity
DLE03_01270	COG1053	succinate dehydrogenase
DLE03_01275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DLE03_01280	COG1950	PFAM Membrane protein of
DLE03_01285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DLE03_01295	COG0006	proline dipeptidase activity
DLE03_01300	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DLE03_01300	COG0506	proline dehydrogenase activity
DLE03_01300	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DLE03_01315	COG2376	Dihydroxyacetone kinase
DLE03_01325	COG1129	ABC transporter
DLE03_01330	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLE03_01335	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLE03_01340	COG1363	Peptidase, m42
DLE03_01350	COG1063	alcohol dehydrogenase
DLE03_01360	COG2084	Dehydrogenase
DLE03_01365	COG0434	BtpA family
DLE03_01370	COG1349	DNA-binding transcription factor activity
DLE03_01390	COG1525	nuclease
DLE03_01390	COG4085	toxin activity
DLE03_01390	COG0737	Belongs to the 5'-nucleotidase family
DLE03_01410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DLE03_01435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DLE03_01440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DLE03_01445	COG0586	Pfam SNARE associated Golgi protein
DLE03_01455	COG3483	tryptophan 2,3-dioxygenase activity
DLE03_01465	COG0488	(ABC) transporter
DLE03_01485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DLE03_01500	COG0531	amino acid
DLE03_01545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DLE03_01560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE03_01565	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DLE03_01575	COG1610	YqeY-like protein
DLE03_01605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLE03_01610	COG0191	fructose-bisphosphate aldolase activity
DLE03_01615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DLE03_01620	COG0151	Belongs to the GarS family
DLE03_01625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DLE03_01630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DLE03_01635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLE03_01640	COG0047	phosphoribosylformylglycinamidine synthase activity
DLE03_01645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLE03_01685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLE03_01720	COG0438	transferase activity, transferring glycosyl groups
DLE03_01725	COG0009	L-threonylcarbamoyladenylate synthase
DLE03_01740	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DLE03_01765	COG2027	D-alanyl-D-alanine carboxypeptidase
DLE03_01775	COG0109	protoheme IX farnesyltransferase activity
DLE03_01800	COG0037	tRNA processing
DLE03_01815	COG0302	gtp cyclohydrolase
DLE03_01820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DLE03_01830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DLE03_01835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DLE03_01840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DLE03_01850	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DLE03_01855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DLE03_01860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DLE03_01870	COG1194	a g-specific adenine glycosylase
DLE03_01875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DLE03_01885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DLE03_01905	COG1061	Type III restriction enzyme res subunit
DLE03_01925	COG0406	alpha-ribazole phosphatase activity
DLE03_01930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DLE03_01935	COG0785	Cytochrome C biogenesis protein
DLE03_01940	COG1333	cytochrome c biogenesis protein
DLE03_01945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DLE03_01970	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DLE03_01975	COG4948	Mandelate Racemase Muconate Lactonizing
DLE03_01980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DLE03_01985	COG1169	isochorismate synthase
DLE03_01990	COG1268	BioY protein
DLE03_01995	COG2226	methyltransferase
DLE03_02010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLE03_02015	COG0649	NAD binding
DLE03_02025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DLE03_02030	COG1034	ATP synthesis coupled electron transport
DLE03_02035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DLE03_02040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLE03_02045	COG0839	Belongs to the complex I subunit 6 family
DLE03_02080	COG1666	GTP binding
DLE03_02090	COG1172	Belongs to the binding-protein-dependent transport system permease family
DLE03_02130	COG4948	Mandelate Racemase Muconate Lactonizing
DLE03_02140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DLE03_02155	COG0395	ABC-type sugar transport system, permease component
DLE03_02160	COG1832	CoA-binding protein
DLE03_02185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DLE03_02190	COG2030	dehydratase
DLE03_02200	COG0215	cysteine-tRNA ligase activity
DLE03_02205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DLE03_02210	COG0436	Aminotransferase
DLE03_02220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DLE03_02230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DLE03_02235	COG0081	regulation of translation
DLE03_02240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DLE03_02245	COG0222	ribosome binding
DLE03_02250	COG0085	RNA polymerase activity
DLE03_02255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DLE03_02265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DLE03_02270	COG0049	tRNA binding
DLE03_02275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DLE03_02280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DLE03_02285	COG0051	transcription antitermination factor activity, RNA binding
DLE03_02290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DLE03_02295	COG0088	Forms part of the polypeptide exit tunnel
DLE03_02300	COG0089	rRNA binding
DLE03_02310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DLE03_02315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DLE03_02320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DLE03_02325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DLE03_02330	COG0255	Belongs to the universal ribosomal protein uL29 family
DLE03_02335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DLE03_02340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DLE03_02345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DLE03_02350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DLE03_02355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DLE03_02360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DLE03_02365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DLE03_02375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DLE03_02380	COG1841	ribosomal large subunit assembly
DLE03_02385	COG0200	Binds to the 23S rRNA
DLE03_02395	COG0563	adenylate kinase activity
DLE03_02400	COG0024	Methionine aminopeptidase
DLE03_02425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DLE03_02430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DLE03_02435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DLE03_02440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DLE03_02445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DLE03_02450	COG0202	RNA polymerase activity
DLE03_02455	COG0203	ribosomal protein L17
DLE03_02460	COG0101	tRNA pseudouridine synthase activity
DLE03_02465	COG0488	(ABC) transporter
DLE03_02470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DLE03_02475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DLE03_02480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE03_02485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLE03_02495	COG0736	holo-[acyl-carrier-protein] synthase activity
DLE03_02500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DLE03_02515	COG0559	Belongs to the binding-protein-dependent transport system permease family
DLE03_02520	COG0559	Belongs to the binding-protein-dependent transport system permease family
DLE03_02535	COG0802	atpase or kinase
DLE03_02540	COG0456	acetyltransferase
DLE03_02540	COG1214	PFAM Peptidase M22, glycoprotease
DLE03_02545	COG0456	acetyltransferase
DLE03_02545	COG1214	PFAM Peptidase M22, glycoprotease
DLE03_02550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DLE03_02555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DLE03_02580	COG0516	GMP reductase activity
DLE03_02585	COG0519	Catalyzes the synthesis of GMP from XMP
DLE03_02585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLE03_02590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DLE03_02595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DLE03_02605	COG0045	succinate-CoA ligase (ADP-forming) activity
DLE03_02630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DLE03_02640	COG0039	L-malate dehydrogenase activity
DLE03_02645	COG0538	isocitrate dehydrogenase activity
DLE03_02655	COG3842	ATPase activity
DLE03_02660	COG1253	flavin adenine dinucleotide binding
DLE03_02665	COG0180	Tryptophanyl-tRNA synthetase
DLE03_02670	COG1744	ABC transporter substrate-binding protein PnrA-like
DLE03_02675	COG1744	ABC transporter substrate-binding protein PnrA-like
DLE03_02705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DLE03_02710	COG1012	belongs to the aldehyde dehydrogenase family
DLE03_02715	COG1012	belongs to the aldehyde dehydrogenase family
DLE03_02725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE03_02735	COG4770	biotin carboxylase activity
DLE03_02740	COG0424	maF-like protein
DLE03_02750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLE03_02765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DLE03_02770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DLE03_02775	COG1316	TRANSCRIPTIONal
DLE03_02800	COG2171	N-acyltransferase activity
DLE03_02805	COG1611	Belongs to the LOG family
DLE03_02825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DLE03_02835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLE03_02840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DLE03_02845	COG2151	metal-sulfur cluster biosynthetic enzyme
DLE03_02845	COG0489	protein tyrosine kinase activity
DLE03_02855	COG2239	Acts as a magnesium transporter
DLE03_02870	COG2095	MarC family integral membrane protein
DLE03_02875	COG0513	Belongs to the DEAD box helicase family
DLE03_02895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DLE03_02905	COG0215	cysteine-tRNA ligase activity
DLE03_02910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DLE03_02945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE03_02950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DLE03_02955	COG0745	RESPONSE REGULATOR receiver
DLE03_02960	COG5000	phosphorelay sensor kinase activity
DLE03_02960	COG5002	protein histidine kinase activity
DLE03_02965	COG1040	competence protein
DLE03_02970	COG0653	protein targeting
DLE03_02985	COG2894	cell division
DLE03_03010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DLE03_03045	COG0745	RESPONSE REGULATOR receiver
DLE03_03050	COG5002	protein histidine kinase activity
DLE03_03060	COG0137	argininosuccinate synthase activity
DLE03_03065	COG0545	Peptidyl-prolyl cis-trans isomerase
DLE03_03070	COG0366	Alpha amylase catalytic
DLE03_03095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DLE03_03110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DLE03_03135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DLE03_03160	COG2814	Major facilitator Superfamily
DLE03_03170	COG0668	transmembrane transport
DLE03_03190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DLE03_03195	COG0698	ribose 5-phosphate isomerase
DLE03_03220	COG0544	peptidyl-prolyl cis-trans isomerase activity
DLE03_03225	COG0740	serine-type endopeptidase activity
DLE03_03230	COG0740	serine-type endopeptidase activity
DLE03_03240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DLE03_03245	COG0525	valine-tRNA ligase activity
DLE03_03250	COG0285	dihydrofolate synthase activity
DLE03_03260	COG0105	UTP biosynthetic process
DLE03_03265	COG1077	Cell shape determining protein MreB Mrl
DLE03_03285	COG0772	Belongs to the SEDS family
DLE03_03290	COG1530	ribonuclease E activity
DLE03_03295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DLE03_03300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DLE03_03305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DLE03_03310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DLE03_03315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DLE03_03320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLE03_03325	COG0154	amidase activity
DLE03_03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLE03_03340	COG0129	dihydroxy-acid dehydratase activity
DLE03_03350	COG0440	acetolactate synthase activity
DLE03_03355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DLE03_03365	COG0473	3-isopropylmalate dehydrogenase activity
DLE03_03370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DLE03_03375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLE03_03395	COG0052	Belongs to the universal ribosomal protein uS2 family
DLE03_03400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DLE03_03405	COG0528	UMP kinase activity
DLE03_03410	COG0233	cytoplasmic translational termination
DLE03_03420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DLE03_03430	COG1012	belongs to the aldehyde dehydrogenase family
DLE03_03440	COG3842	ATPase activity
DLE03_03445	COG1176	ABC-type spermidine putrescine transport system, permease component I
DLE03_03460	COG0750	zinc metalloprotease
DLE03_03465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DLE03_03470	COG0442	prolyl-tRNA aminoacylation
DLE03_03475	COG0730	response to heat
DLE03_03480	COG0779	Required for maturation of 30S ribosomal subunits
DLE03_03490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DLE03_03490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DLE03_03495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DLE03_03500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DLE03_03515	COG1185	polyribonucleotide nucleotidyltransferase activity
DLE03_03520	COG0612	Peptidase, M16
DLE03_03525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DLE03_03545	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DLE03_03550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLE03_03555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DLE03_03560	COG1674	ftsk spoiiie
DLE03_03570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DLE03_03580	COG1058	Belongs to the CinA family
DLE03_03580	COG1546	Belongs to the CinA family
DLE03_03585	COG1396	sequence-specific DNA binding
DLE03_03615	COG2137	regulation of response to DNA damage stimulus
DLE03_03625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DLE03_03630	COG0066	3-isopropylmalate dehydratase activity
DLE03_03635	COG0776	regulation of translation
DLE03_03645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DLE03_03650	COG1181	Belongs to the D-alanine--D-alanine ligase family
DLE03_03665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DLE03_03675	COG0742	ribosomal rna small subunit methyltransferase
DLE03_03680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DLE03_03695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DLE03_03700	COG0571	ribonuclease III activity
DLE03_03710	COG0552	protein localization to endoplasmic reticulum
DLE03_03725	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DLE03_03730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DLE03_03735	COG0228	four-way junction DNA binding
DLE03_03740	COG1837	Belongs to the UPF0109 family
DLE03_03745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DLE03_03750	COG0336	Belongs to the RNA methyltransferase TrmD family
DLE03_03760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DLE03_03765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DLE03_03770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DLE03_03775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DLE03_03795	COG0756	dUTP diphosphatase activity
DLE03_03810	COG0569	domain protein
DLE03_03815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DLE03_03820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DLE03_03825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DLE03_03830	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLE03_03830	COG1024	Enoyl-CoA hydratase
DLE03_03840	COG0672	)-iron permease
DLE03_03865	COG0791	NLP P60 protein
DLE03_03870	COG0438	transferase activity, transferring glycosyl groups
DLE03_03895	COG1940	carbohydrate kinase activity
DLE03_03915	COG1280	lysine exporter protein (LysE YggA)
DLE03_03925	COG1260	myo-inositol-1-phosphate synthase
DLE03_03930	COG1024	Enoyl-CoA hydratase
DLE03_03935	COG0300	oxidoreductase activity
DLE03_03940	COG1126	abc transporter atp-binding protein
DLE03_03945	COG0765	amino acid transport
DLE03_03950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLE03_03960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DLE03_03965	COG0174	glutamine synthetase
DLE03_03985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DLE03_03990	COG0321	lipoyl(octanoyl) transferase activity
DLE03_03995	COG2409	Drug exporters of the RND superfamily
DLE03_04000	COG0673	inositol 2-dehydrogenase activity
DLE03_04005	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DLE03_04010	COG1090	epimerase
DLE03_04015	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLE03_04020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLE03_04025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DLE03_04030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DLE03_04040	COG3845	ABC transporter
DLE03_04045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DLE03_04055	COG0667	Aldo Keto reductase
DLE03_04065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DLE03_04075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE03_04085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DLE03_04090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLE03_04110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DLE03_04115	COG0723	plastoquinol--plastocyanin reductase activity
DLE03_04125	COG1845	cytochrome c oxidase, subunit III
DLE03_04135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DLE03_04150	COG2986	histidine ammonia-lyase
DLE03_04155	COG1228	amidohydrolase
DLE03_04160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DLE03_04195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLE03_04200	COG3938	Belongs to the proline racemase family
DLE03_04210	COG0697	spore germination
DLE03_04240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DLE03_04250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DLE03_04265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DLE03_04270	COG1560	Kdo2-lipid A biosynthetic process
DLE03_04275	COG0438	transferase activity, transferring glycosyl groups
DLE03_04295	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DLE03_04300	COG0217	transcriptional regulatory protein
DLE03_04305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DLE03_04310	COG0632	four-way junction helicase activity
DLE03_04315	COG2255	four-way junction helicase activity
DLE03_04320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLE03_04325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLE03_04330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLE03_04335	COG1196	nuclear chromosome segregation
DLE03_04340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLE03_04345	COG0124	histidyl-tRNA synthetase
DLE03_04350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DLE03_04360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DLE03_04365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DLE03_04375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DLE03_04385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DLE03_04390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DLE03_04395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DLE03_04400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DLE03_04405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DLE03_04410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DLE03_04420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DLE03_04425	COG0540	Belongs to the ATCase OTCase family
DLE03_04430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DLE03_04435	COG0505	Belongs to the CarA family
DLE03_04440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DLE03_04445	COG0543	2 iron, 2 sulfur cluster binding
DLE03_04450	COG0167	dihydroorotate dehydrogenase activity
DLE03_04455	COG0284	orotidine-5'-phosphate decarboxylase activity
DLE03_04460	COG0194	GDP metabolic process
DLE03_04465	COG1758	RNA polymerase activity
DLE03_04475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DLE03_04485	COG0242	peptide deformylase activity
DLE03_04490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DLE03_04500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DLE03_04505	COG0140	phosphoribosyl-ATP diphosphatase activity
DLE03_04510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DLE03_04515	COG0560	Phosphoserine phosphatase
DLE03_04515	COG3830	Belongs to the UPF0237 family
DLE03_04520	COG1119	ATPase activity
DLE03_04525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DLE03_04530	COG2252	PERMEase
DLE03_04535	COG2364	Membrane
DLE03_04540	COG1811	Na channel or pump
DLE03_04545	COG1064	alcohol dehydrogenase
DLE03_04550	COG1435	thymidine kinase activity
DLE03_04555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DLE03_04555	COG2755	lipolytic protein G-D-S-L family
DLE03_04560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DLE03_04570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DLE03_04575	COG0667	Aldo Keto reductase
DLE03_04595	COG0215	cysteine-tRNA ligase activity
DLE03_04605	COG1410	methionine synthase
DLE03_04605	COG0646	methionine synthase
DLE03_04620	COG2378	regulation of single-species biofilm formation
DLE03_04630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DLE03_04635	COG0805	protein transport
DLE03_04650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DLE03_04655	COG0463	Glycosyl transferase, family 2
DLE03_04660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DLE03_04660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DLE03_04690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DLE03_04695	COG1160	GTP binding
DLE03_04715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DLE03_04720	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DLE03_04740	COG0504	CTP synthase activity
DLE03_04745	COG0497	DNA recombination
DLE03_04750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DLE03_04790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DLE03_04795	COG0165	Argininosuccinate lyase
DLE03_04800	COG1438	arginine binding
DLE03_04805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLE03_04815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DLE03_04820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DLE03_04825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLE03_04825	COG0072	phenylalanine-tRNA ligase activity
DLE03_04830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DLE03_04835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DLE03_04840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DLE03_04845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DLE03_04850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DLE03_04855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DLE03_04875	COG1132	(ABC) transporter
DLE03_04880	COG2151	metal-sulfur cluster biosynthetic enzyme
DLE03_04885	COG0822	iron-sulfur transferase activity
DLE03_04890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DLE03_04895	COG0396	ATPase activity
DLE03_04900	COG2146	nitrite reductase [NAD(P)H] activity
DLE03_04905	COG0719	Fe-S assembly protein
DLE03_04920	COG1612	heme a metabolic process
DLE03_04925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DLE03_04930	COG0166	Belongs to the GPI family
DLE03_04945	COG0149	triose-phosphate isomerase activity
DLE03_04950	COG0126	phosphoglycerate kinase activity
DLE03_04955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DLE03_04960	COG1481	regulation of sporulation
DLE03_04970	COG1660	Displays ATPase and GTPase activities
DLE03_04975	COG0322	excinuclease ABC activity
DLE03_04980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DLE03_04985	COG0556	nucleotide-excision repair
DLE03_04990	COG0237	dephospho-CoA kinase activity
DLE03_04995	COG0539	negative regulation of cytoplasmic translation
DLE03_05010	COG2050	protein possibly involved in aromatic compounds catabolism
DLE03_05060	COG0067	glutamate synthase
DLE03_05060	COG0069	glutamate synthase activity
DLE03_05060	COG0070	glutamate synthase
DLE03_05070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DLE03_05085	COG0159	tryptophan synthase activity
DLE03_05090	COG0133	tryptophan synthase activity
DLE03_05095	COG0134	indole-3-glycerol-phosphate synthase activity
DLE03_05100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DLE03_05105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DLE03_05110	COG0107	imidazoleglycerol-phosphate synthase activity
DLE03_05115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DLE03_05125	COG0131	Imidazoleglycerol-phosphate dehydratase
DLE03_05130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DLE03_05135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DLE03_05150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DLE03_05160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DLE03_05170	COG1799	cell septum assembly
DLE03_05175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DLE03_05185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DLE03_05195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DLE03_05200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DLE03_05210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DLE03_05215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLE03_05220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DLE03_05225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DLE03_05230	COG0768	penicillin binding
DLE03_05240	COG0275	rRNA processing
DLE03_05245	COG2001	Belongs to the MraZ family
DLE03_05255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DLE03_05260	COG0587	DNA-directed DNA polymerase activity
DLE03_05275	COG0730	response to heat
DLE03_05280	COG2271	Major facilitator Superfamily
DLE03_05290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DLE03_05310	COG0463	Glycosyl transferase, family 2
DLE03_05320	COG1183	phosphatidylcholine synthase activity
DLE03_05350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DLE03_05350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DLE03_05355	COG0515	serine threonine protein kinase
DLE03_05355	COG2815	serine threonine protein kinase
DLE03_05360	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DLE03_05375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DLE03_05380	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DLE03_05385	COG0205	6-phosphofructokinase activity
DLE03_05390	COG1070	Carbohydrate kinase
DLE03_05395	COG3046	protein related to deoxyribodipyrimidine photolyase
DLE03_05405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DLE03_05410	COG0297	glycogen (starch) synthase activity
DLE03_05420	COG1968	undecaprenyl-diphosphatase activity
DLE03_05425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DLE03_05440	COG0792	nuclease activity
DLE03_05445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DLE03_05450	COG0681	Belongs to the peptidase S26 family
DLE03_05455	COG0335	large ribosomal subunit rRNA binding
DLE03_05475	COG2313	pseudouridylate synthase activity
DLE03_05480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE03_05485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DLE03_05495	COG0488	(ABC) transporter
DLE03_05515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DLE03_05520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DLE03_05540	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DLE03_05545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLE03_05550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DLE03_05575	COG0697	spore germination
DLE03_05585	COG1012	belongs to the aldehyde dehydrogenase family
DLE03_05590	COG4948	Mandelate Racemase Muconate Lactonizing
DLE03_05605	COG1174	glycine betaine transport
DLE03_05615	COG1174	glycine betaine transport
DLE03_05630	COG3384	dioxygenase
DLE03_05640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DLE03_05665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DLE03_05670	COG1388	LysM domain
DLE03_05675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DLE03_05705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLE03_05705	COG0519	Catalyzes the synthesis of GMP from XMP
DLE03_05710	COG1028	Short-chain dehydrogenase reductase Sdr
DLE03_05715	COG1012	belongs to the aldehyde dehydrogenase family
DLE03_05900	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLE03_05905	COG1929	Belongs to the glycerate kinase type-1 family
DLE03_05910	COG0833	amino acid
DLE03_05920	COG0277	FAD linked oxidase domain protein
DLE03_05935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLE03_05935	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DLE03_05940	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLE03_05965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DLE03_05970	COG0484	heat shock protein binding
DLE03_05975	COG1420	regulation of RNA biosynthetic process
DLE03_05985	COG0481	GTPase activity
DLE03_05990	COG0268	Binds directly to 16S ribosomal RNA
DLE03_06010	COG0495	leucyl-tRNA aminoacylation
DLE03_06020	COG0406	alpha-ribazole phosphatase activity
DLE03_06025	COG0799	negative regulation of ribosome biogenesis
DLE03_06030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DLE03_06035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DLE03_06040	COG0482	sulfurtransferase activity
DLE03_06050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DLE03_06060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DLE03_06060	COG0438	transferase activity, transferring glycosyl groups
DLE03_06065	COG0438	transferase activity, transferring glycosyl groups
DLE03_06085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DLE03_06090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLE03_06120	COG1278	Cold shock
DLE03_06145	COG0686	Belongs to the AlaDH PNT family
DLE03_06160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DLE03_06185	COG5002	protein histidine kinase activity
DLE03_06190	COG0745	RESPONSE REGULATOR receiver
DLE03_06200	COG2197	response regulator
DLE03_06215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DLE03_06220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLE03_06230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DLE03_06245	COG0723	plastoquinol--plastocyanin reductase activity
DLE03_06260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DLE03_06275	COG0423	glycine-tRNA ligase activity
DLE03_06290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DLE03_06295	COG1381	Involved in DNA repair and RecF pathway recombination
DLE03_06300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLE03_06320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DLE03_06320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLE03_06325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DLE03_06345	COG3590	peptidase
DLE03_06355	COG4608	Belongs to the ABC transporter superfamily
DLE03_06360	COG0444	Belongs to the ABC transporter superfamily
DLE03_06370	COG4166	transmembrane transport
DLE03_06375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLE03_06400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DLE03_06405	COG0363	glucosamine-6-phosphate deaminase activity
DLE03_06415	COG2909	trisaccharide binding
DLE03_06425	COG1982	Orn Lys Arg decarboxylase major
DLE03_06470	COG3962	Belongs to the TPP enzyme family
DLE03_06485	COG0673	inositol 2-dehydrogenase activity
DLE03_06490	COG0673	inositol 2-dehydrogenase activity
DLE03_06495	COG0697	spore germination
DLE03_06525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DLE03_06525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE03_06530	COG2311	Membrane
DLE03_06550	COG1063	alcohol dehydrogenase
DLE03_06560	COG0395	ABC-type sugar transport system, permease component
DLE03_06620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DLE03_06625	COG0366	Alpha amylase catalytic
DLE03_06630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DLE03_06660	COG1012	belongs to the aldehyde dehydrogenase family
DLE03_06670	COG1131	(ABC) transporter
DLE03_06705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DLE03_06710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DLE03_06715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DLE03_06720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DLE03_06725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DLE03_06730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DLE03_06735	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DLE03_06740	COG0356	it plays a direct role in the translocation of protons across the membrane
DLE03_06760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DLE03_06770	COG2890	protein-(glutamine-N5) methyltransferase activity
DLE03_06775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DLE03_06780	COG0254	rRNA binding
DLE03_06795	COG0083	homoserine kinase activity
DLE03_06800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DLE03_06805	COG0460	homoserine dehydrogenase
DLE03_06815	COG0018	arginyl-trna synthetase
DLE03_06820	COG4213	ABC transporter substrate-binding protein
DLE03_06830	COG4214	carbohydrate transport
DLE03_06885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DLE03_06890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DLE03_06895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DLE03_06920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DLE03_06950	COG1741	Belongs to the pirin family
DLE03_06975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline