locus-tag	class	description
DLE04_00005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DLE04_00010	COG2177	Part of the ABC transporter FtsEX involved in
DLE04_00015	COG2884	Cell division ATP-binding protein ftsE
DLE04_00020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DLE04_00060	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_00065	COG0567	Dehydrogenase, E1 component
DLE04_00065	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLE04_00090	COG1595	DNA-templated transcription, initiation
DLE04_00095	COG2135	peptidase activity
DLE04_00100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DLE04_00105	COG1162	GTPase activity
DLE04_00110	COG0483	inositol monophosphate 1-phosphatase activity
DLE04_00130	COG1615	UPF0182 protein
DLE04_00135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DLE04_00190	COG0210	DNA helicase
DLE04_00210	COG0012	GTP binding
DLE04_00215	COG1322	Protein conserved in bacteria
DLE04_00225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DLE04_00230	COG1570	exodeoxyribonuclease VII activity
DLE04_00235	COG1722	exodeoxyribonuclease VII activity
DLE04_00250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DLE04_00255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DLE04_00275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DLE04_00290	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_00295	COG1063	alcohol dehydrogenase
DLE04_00300	COG0129	dihydroxy-acid dehydratase activity
DLE04_00340	COG1063	alcohol dehydrogenase
DLE04_00375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DLE04_00440	COG0148	phosphopyruvate hydratase activity
DLE04_00460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DLE04_00465	COG0193	aminoacyl-tRNA hydrolase activity
DLE04_00470	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DLE04_00475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DLE04_00480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DLE04_00495	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DLE04_00500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DLE04_00505	COG0084	hydrolase, TatD family'
DLE04_00510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLE04_00530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DLE04_00540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DLE04_00545	COG1960	acyl-CoA dehydrogenase activity
DLE04_00565	COG2409	Drug exporters of the RND superfamily
DLE04_00580	COG0300	oxidoreductase activity
DLE04_00610	COG0259	pyridoxamine-phosphate oxidase activity
DLE04_00615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DLE04_00635	COG1278	Cold shock
DLE04_00645	COG0459	protein refolding
DLE04_00660	COG0702	epimerase
DLE04_00665	COG1252	NADH dehydrogenase
DLE04_00670	COG0596	Alpha beta hydrolase
DLE04_00685	COG0248	Ppx GppA phosphatase
DLE04_00695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DLE04_00710	COG0215	cysteine-tRNA ligase activity
DLE04_00715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DLE04_00715	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DLE04_00720	COG1329	Transcriptional regulator
DLE04_00730	COG0588	phosphoglycerate mutase activity
DLE04_00740	COG0438	transferase activity, transferring glycosyl groups
DLE04_00750	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DLE04_00755	COG0354	folic acid binding
DLE04_00760	COG0735	belongs to the Fur family
DLE04_00770	COG2897	thiosulfate sulfurtransferase activity
DLE04_00785	COG0745	RESPONSE REGULATOR receiver
DLE04_00790	COG0456	acetyltransferase
DLE04_00800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DLE04_00815	COG4702	Belongs to the UPF0303 family
DLE04_00825	COG0667	Aldo Keto reductase
DLE04_00840	COG1017	nitric oxide dioxygenase activity
DLE04_00840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLE04_00845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE04_00885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DLE04_00900	COG1132	(ABC) transporter
DLE04_00910	COG0438	transferase activity, transferring glycosyl groups
DLE04_00925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE04_00930	COG0438	transferase activity, transferring glycosyl groups
DLE04_00940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DLE04_01010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE04_01025	COG3959	Transketolase, thiamine diphosphate binding domain
DLE04_01055	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_01065	COG1083	cytidylyl-transferase
DLE04_01070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DLE04_01080	COG2089	acid synthase
DLE04_01085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DLE04_01105	COG0470	DNA polymerase III
DLE04_01110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DLE04_01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DLE04_01140	COG1754	DNA topoisomerase type I activity
DLE04_01145	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DLE04_01150	COG0586	Pfam SNARE associated Golgi protein
DLE04_01155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DLE04_01160	COG0789	Transcriptional regulator
DLE04_01165	COG0484	heat shock protein binding
DLE04_01170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DLE04_01175	COG0443	Heat shock 70 kDa protein
DLE04_01180	COG0247	lactate metabolic process
DLE04_01180	COG2181	nitrate reductase activity
DLE04_01185	COG0705	Rhomboid family
DLE04_01205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DLE04_01210	COG0187	DNA topoisomerase II activity
DLE04_01220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DLE04_01225	COG0592	DNA-directed DNA polymerase activity
DLE04_01230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DLE04_01235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DLE04_01245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DLE04_01250	COG0706	membrane insertase activity
DLE04_01260	COG0357	Ribosomal RNA small subunit methyltransferase G
DLE04_01265	COG1192	Involved in chromosome partitioning
DLE04_01270	COG1475	DNA binding
DLE04_01275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLE04_01280	COG0860	N-Acetylmuramoyl-L-alanine amidase
DLE04_01280	COG3409	Peptidoglycan-binding domain 1 protein
DLE04_01285	COG3118	belongs to the thioredoxin family
DLE04_01290	COG0492	ferredoxin-NADP+ reductase activity
DLE04_01310	COG0617	tRNA 3'-terminal CCA addition
DLE04_01325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DLE04_01335	COG0360	Binds together with S18 to 16S ribosomal RNA
DLE04_01345	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DLE04_01350	COG0359	binds to the 23S rRNA
DLE04_01355	COG0305	Participates in initiation and elongation during chromosome replication
DLE04_01365	COG1960	acyl-CoA dehydrogenase activity
DLE04_01370	COG0717	Belongs to the dCTP deaminase family
DLE04_01375	COG1704	LemA family
DLE04_01380	COG0501	Belongs to the peptidase M48B family
DLE04_01385	COG2205	protein histidine kinase activity
DLE04_01390	COG0745	RESPONSE REGULATOR receiver
DLE04_01405	COG0515	serine threonine protein kinase
DLE04_01420	COG0077	Prephenate dehydratase
DLE04_01425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DLE04_01430	COG0561	phosphatase activity
DLE04_01445	COG1053	succinate dehydrogenase
DLE04_01455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DLE04_01465	COG0006	proline dipeptidase activity
DLE04_01470	COG3959	Transketolase, thiamine diphosphate binding domain
DLE04_01475	COG3958	Transketolase
DLE04_01480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLE04_01485	COG1082	Xylose isomerase domain protein TIM barrel
DLE04_01500	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_01530	COG4221	oxidoreductase activity
DLE04_01535	COG0673	inositol 2-dehydrogenase activity
DLE04_01540	COG1082	Xylose isomerase domain protein TIM barrel
DLE04_01545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DLE04_01575	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_01625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE04_01630	COG1869	D-ribose catabolic process
DLE04_01640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DLE04_01645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DLE04_01655	COG3483	tryptophan 2,3-dioxygenase activity
DLE04_01660	COG3844	kynureninase activity
DLE04_01665	COG0488	(ABC) transporter
DLE04_01670	COG2862	Uncharacterized protein family, UPF0114
DLE04_01680	COG0586	Pfam SNARE associated Golgi protein
DLE04_01690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DLE04_01700	COG0590	tRNA wobble adenosine to inosine editing
DLE04_01705	COG0531	amino acid
DLE04_01730	COG1476	TRANSCRIPTIONal
DLE04_01750	COG2197	response regulator
DLE04_01775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DLE04_01790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE04_01795	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DLE04_01800	COG1408	metallophosphoesterase
DLE04_01805	COG1610	YqeY-like protein
DLE04_01835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLE04_01840	COG0191	fructose-bisphosphate aldolase activity
DLE04_01845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DLE04_01850	COG0151	Belongs to the GarS family
DLE04_01855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DLE04_01860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DLE04_01865	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLE04_01870	COG0047	phosphoribosylformylglycinamidine synthase activity
DLE04_01875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLE04_01910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLE04_01945	COG0009	L-threonylcarbamoyladenylate synthase
DLE04_01975	COG1845	cytochrome c oxidase, subunit III
DLE04_01975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLE04_01990	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DLE04_02015	COG2027	D-alanyl-D-alanine carboxypeptidase
DLE04_02030	COG0109	protoheme IX farnesyltransferase activity
DLE04_02050	COG0791	NLP P60 protein
DLE04_02055	COG0037	tRNA processing
DLE04_02070	COG0302	gtp cyclohydrolase
DLE04_02080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DLE04_02085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DLE04_02090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DLE04_02095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DLE04_02105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DLE04_02110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DLE04_02115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DLE04_02125	COG0277	FAD linked oxidase domain protein
DLE04_02130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DLE04_02140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DLE04_02185	COG0406	alpha-ribazole phosphatase activity
DLE04_02190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DLE04_02195	COG0785	Cytochrome C biogenesis protein
DLE04_02200	COG1333	cytochrome c biogenesis protein
DLE04_02205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DLE04_02220	COG0318	PFAM AMP-dependent synthetase and ligase
DLE04_02230	COG4948	Mandelate Racemase Muconate Lactonizing
DLE04_02235	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DLE04_02240	COG1169	isochorismate synthase
DLE04_02250	COG2226	methyltransferase
DLE04_02260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLE04_02265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLE04_02270	COG0649	NAD binding
DLE04_02280	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DLE04_02285	COG1034	ATP synthesis coupled electron transport
DLE04_02290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DLE04_02295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLE04_02300	COG0839	Belongs to the complex I subunit 6 family
DLE04_02335	COG1666	GTP binding
DLE04_02370	COG1175	transmembrane transport
DLE04_02375	COG0395	ABC-type sugar transport system, permease component
DLE04_02380	COG2186	Transcriptional regulator
DLE04_02385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE04_02390	COG3684	Belongs to the aldolase LacD family
DLE04_02395	COG0673	inositol 2-dehydrogenase activity
DLE04_02405	COG2721	sulfolactate sulfo-lyase activity
DLE04_02410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DLE04_02415	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DLE04_02420	COG2855	membrane
DLE04_02435	COG1126	abc transporter atp-binding protein
DLE04_02440	COG0235	Class ii aldolase
DLE04_02440	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DLE04_02445	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_02445	COG3347	Dehydrogenase
DLE04_02475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DLE04_02480	COG2030	dehydratase
DLE04_02495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DLE04_02505	COG0436	Aminotransferase
DLE04_02525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DLE04_02530	COG0081	regulation of translation
DLE04_02535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DLE04_02540	COG0222	ribosome binding
DLE04_02550	COG0085	RNA polymerase activity
DLE04_02555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DLE04_02560	COG0813	purine-nucleoside phosphorylase activity
DLE04_02565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DLE04_02570	COG0049	tRNA binding
DLE04_02575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DLE04_02580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DLE04_02585	COG0051	transcription antitermination factor activity, RNA binding
DLE04_02590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DLE04_02595	COG0088	Forms part of the polypeptide exit tunnel
DLE04_02600	COG0089	rRNA binding
DLE04_02615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DLE04_02620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DLE04_02625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DLE04_02630	COG0255	Belongs to the universal ribosomal protein uL29 family
DLE04_02635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DLE04_02640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DLE04_02650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DLE04_02655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DLE04_02660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DLE04_02665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DLE04_02670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DLE04_02675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DLE04_02680	COG1841	ribosomal large subunit assembly
DLE04_02685	COG0200	Binds to the 23S rRNA
DLE04_02695	COG0563	adenylate kinase activity
DLE04_02700	COG0024	Methionine aminopeptidase
DLE04_02725	COG1595	DNA-templated transcription, initiation
DLE04_02755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DLE04_02760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DLE04_02765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DLE04_02770	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DLE04_02775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DLE04_02780	COG0202	RNA polymerase activity
DLE04_02785	COG0203	ribosomal protein L17
DLE04_02790	COG0101	tRNA pseudouridine synthase activity
DLE04_02800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DLE04_02805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DLE04_02810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE04_02815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLE04_02825	COG0736	holo-[acyl-carrier-protein] synthase activity
DLE04_02830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DLE04_02835	COG0411	ABC transporter
DLE04_02870	COG1214	PFAM Peptidase M22, glycoprotease
DLE04_02870	COG0456	acetyltransferase
DLE04_02880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DLE04_02885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DLE04_02890	COG0459	protein refolding
DLE04_02915	COG0516	GMP reductase activity
DLE04_02920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLE04_02920	COG0519	Catalyzes the synthesis of GMP from XMP
DLE04_02940	COG0045	succinate-CoA ligase (ADP-forming) activity
DLE04_02965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DLE04_02990	COG2160	L-arabinose isomerase activity
DLE04_03000	COG1175	transmembrane transport
DLE04_03005	COG0395	ABC-type sugar transport system, permease component
DLE04_03015	COG0148	phosphopyruvate hydratase activity
DLE04_03020	COG3842	ATPase activity
DLE04_03025	COG1253	flavin adenine dinucleotide binding
DLE04_03030	COG0180	Tryptophanyl-tRNA synthetase
DLE04_03050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DLE04_03055	COG1012	belongs to the aldehyde dehydrogenase family
DLE04_03060	COG1012	belongs to the aldehyde dehydrogenase family
DLE04_03070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE04_03080	COG4770	biotin carboxylase activity
DLE04_03085	COG0424	maF-like protein
DLE04_03095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLE04_03110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DLE04_03115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DLE04_03120	COG1316	TRANSCRIPTIONal
DLE04_03125	COG1216	Glycosyl transferase, family 2
DLE04_03145	COG2171	N-acyltransferase activity
DLE04_03150	COG1611	Belongs to the LOG family
DLE04_03170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DLE04_03190	COG2151	metal-sulfur cluster biosynthetic enzyme
DLE04_03190	COG0489	protein tyrosine kinase activity
DLE04_03200	COG2239	Acts as a magnesium transporter
DLE04_03215	COG2095	MarC family integral membrane protein
DLE04_03230	COG0513	Belongs to the DEAD box helicase family
DLE04_03250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DLE04_03260	COG0215	cysteine-tRNA ligase activity
DLE04_03305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE04_03310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DLE04_03315	COG0745	RESPONSE REGULATOR receiver
DLE04_03320	COG5002	protein histidine kinase activity
DLE04_03330	COG0653	protein targeting
DLE04_03370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DLE04_03375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DLE04_03420	COG0745	RESPONSE REGULATOR receiver
DLE04_03440	COG0137	argininosuccinate synthase activity
DLE04_03445	COG0545	Peptidyl-prolyl cis-trans isomerase
DLE04_03455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DLE04_03500	COG0489	protein tyrosine kinase activity
DLE04_03530	COG0110	maltose O-acetyltransferase activity
DLE04_03595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DLE04_03635	COG0668	transmembrane transport
DLE04_03655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DLE04_03660	COG0698	ribose 5-phosphate isomerase
DLE04_03675	COG3842	ATPase activity
DLE04_03680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DLE04_03685	COG1176	ABC-type spermidine putrescine transport system, permease component I
DLE04_03690	COG1177	transmembrane transport
DLE04_03705	COG0544	peptidyl-prolyl cis-trans isomerase activity
DLE04_03715	COG0740	serine-type endopeptidase activity
DLE04_03720	COG0740	serine-type endopeptidase activity
DLE04_03730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DLE04_03735	COG0525	valine-tRNA ligase activity
DLE04_03740	COG0285	dihydrofolate synthase activity
DLE04_03750	COG0105	UTP biosynthetic process
DLE04_03755	COG1077	Cell shape determining protein MreB Mrl
DLE04_03775	COG0772	Belongs to the SEDS family
DLE04_03780	COG1530	ribonuclease E activity
DLE04_03785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DLE04_03790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DLE04_03795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DLE04_03800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DLE04_03805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DLE04_03810	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLE04_03815	COG0154	amidase activity
DLE04_03820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLE04_03825	COG0129	dihydroxy-acid dehydratase activity
DLE04_03840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DLE04_03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DLE04_03850	COG0473	3-isopropylmalate dehydrogenase activity
DLE04_03855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DLE04_03860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLE04_03865	COG4974	Belongs to the 'phage' integrase family
DLE04_03870	COG0052	Belongs to the universal ribosomal protein uS2 family
DLE04_03875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DLE04_03880	COG0528	UMP kinase activity
DLE04_03885	COG0233	cytoplasmic translational termination
DLE04_03895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DLE04_03915	COG3842	ATPase activity
DLE04_03920	COG1176	ABC-type spermidine putrescine transport system, permease component I
DLE04_03945	COG0750	zinc metalloprotease
DLE04_03950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DLE04_03955	COG0442	prolyl-tRNA aminoacylation
DLE04_03965	COG0779	Required for maturation of 30S ribosomal subunits
DLE04_03980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DLE04_03980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DLE04_03985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DLE04_03990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DLE04_04005	COG1185	polyribonucleotide nucleotidyltransferase activity
DLE04_04010	COG0612	Peptidase, M16
DLE04_04015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DLE04_04035	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DLE04_04040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLE04_04050	COG1674	ftsk spoiiie
DLE04_04060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DLE04_04070	COG1058	Belongs to the CinA family
DLE04_04070	COG1546	Belongs to the CinA family
DLE04_04075	COG1396	sequence-specific DNA binding
DLE04_04090	COG3022	response to hydroperoxide
DLE04_04095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DLE04_04100	COG2137	regulation of response to DNA damage stimulus
DLE04_04110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DLE04_04115	COG0066	3-isopropylmalate dehydratase activity
DLE04_04120	COG0776	regulation of translation
DLE04_04130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DLE04_04135	COG1181	Belongs to the D-alanine--D-alanine ligase family
DLE04_04150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DLE04_04160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DLE04_04165	COG1271	oxidase subunit
DLE04_04170	COG1294	oxidase, subunit
DLE04_04175	COG4988	ABC transporter
DLE04_04180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DLE04_04190	COG0742	ribosomal rna small subunit methyltransferase
DLE04_04195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DLE04_04210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DLE04_04215	COG0571	ribonuclease III activity
DLE04_04240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DLE04_04250	COG0228	four-way junction DNA binding
DLE04_04255	COG1837	Belongs to the UPF0109 family
DLE04_04260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DLE04_04265	COG0336	Belongs to the RNA methyltransferase TrmD family
DLE04_04275	COG0519	Catalyzes the synthesis of GMP from XMP
DLE04_04275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLE04_04280	COG1454	alcohol dehydrogenase
DLE04_04285	COG1012	belongs to the aldehyde dehydrogenase family
DLE04_04310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DLE04_04315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DLE04_04320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DLE04_04325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DLE04_04345	COG0756	dUTP diphosphatase activity
DLE04_04360	COG0569	domain protein
DLE04_04365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DLE04_04370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DLE04_04375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DLE04_04380	COG1024	Enoyl-CoA hydratase
DLE04_04380	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLE04_04385	COG0183	Belongs to the thiolase family
DLE04_04390	COG0672	)-iron permease
DLE04_04420	COG0791	NLP P60 protein
DLE04_04425	COG0438	transferase activity, transferring glycosyl groups
DLE04_04430	COG2197	response regulator
DLE04_04450	COG1940	carbohydrate kinase activity
DLE04_04465	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DLE04_04470	COG1280	lysine exporter protein (LysE YggA)
DLE04_04475	COG2233	PERMEase
DLE04_04490	COG1024	Enoyl-CoA hydratase
DLE04_04495	COG0300	oxidoreductase activity
DLE04_04515	COG0174	glutamine synthetase
DLE04_04535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DLE04_04540	COG0321	lipoyl(octanoyl) transferase activity
DLE04_04545	COG2409	Drug exporters of the RND superfamily
DLE04_04560	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLE04_04565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLE04_04570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DLE04_04575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DLE04_04585	COG3845	ABC transporter
DLE04_04600	COG0667	Aldo Keto reductase
DLE04_04610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DLE04_04620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE04_04630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DLE04_04635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLE04_04650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DLE04_04655	COG0723	plastoquinol--plastocyanin reductase activity
DLE04_04660	COG2010	Cytochrome c
DLE04_04665	COG1845	cytochrome c oxidase, subunit III
DLE04_04675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DLE04_04690	COG0154	amidase activity
DLE04_04710	COG4213	ABC transporter substrate-binding protein
DLE04_04720	COG4214	carbohydrate transport
DLE04_04760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DLE04_04775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DLE04_04780	COG1560	Kdo2-lipid A biosynthetic process
DLE04_04785	COG0438	transferase activity, transferring glycosyl groups
DLE04_04800	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DLE04_04810	COG0217	transcriptional regulatory protein
DLE04_04815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DLE04_04820	COG0632	four-way junction helicase activity
DLE04_04825	COG2255	four-way junction helicase activity
DLE04_04830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLE04_04835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLE04_04840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLE04_04845	COG1196	nuclear chromosome segregation
DLE04_04850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLE04_04855	COG0124	histidyl-tRNA synthetase
DLE04_04860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DLE04_04870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DLE04_04875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DLE04_04885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DLE04_04895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DLE04_04900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DLE04_04905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DLE04_04910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DLE04_04915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DLE04_04920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DLE04_04930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DLE04_04935	COG0540	Belongs to the ATCase OTCase family
DLE04_04940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DLE04_04945	COG0505	Belongs to the CarA family
DLE04_04950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DLE04_04955	COG0543	2 iron, 2 sulfur cluster binding
DLE04_04960	COG0167	dihydroorotate dehydrogenase activity
DLE04_04965	COG0284	orotidine-5'-phosphate decarboxylase activity
DLE04_04970	COG0194	GDP metabolic process
DLE04_04975	COG1758	RNA polymerase activity
DLE04_04985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DLE04_04995	COG0242	peptide deformylase activity
DLE04_05000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DLE04_05010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DLE04_05020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DLE04_05025	COG3830	Belongs to the UPF0237 family
DLE04_05025	COG0560	Phosphoserine phosphatase
DLE04_05030	COG1119	ATPase activity
DLE04_05040	COG2252	PERMEase
DLE04_05045	COG2364	Membrane
DLE04_05055	COG1064	alcohol dehydrogenase
DLE04_05060	COG1435	thymidine kinase activity
DLE04_05065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DLE04_05065	COG2755	lipolytic protein G-D-S-L family
DLE04_05070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DLE04_05080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DLE04_05085	COG0667	Aldo Keto reductase
DLE04_05105	COG0215	cysteine-tRNA ligase activity
DLE04_05115	COG1410	methionine synthase
DLE04_05115	COG0646	methionine synthase
DLE04_05120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLE04_05140	COG2378	regulation of single-species biofilm formation
DLE04_05150	COG0805	protein transport
DLE04_05165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DLE04_05180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DLE04_05180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DLE04_05200	COG1716	ATPase activity
DLE04_05205	COG0509	glycine decarboxylation via glycine cleavage system
DLE04_05215	COG1160	GTP binding
DLE04_05235	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DLE04_05240	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DLE04_05260	COG0686	Belongs to the AlaDH PNT family
DLE04_05265	COG0504	CTP synthase activity
DLE04_05270	COG0497	DNA recombination
DLE04_05275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DLE04_05315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DLE04_05320	COG0165	Argininosuccinate lyase
DLE04_05325	COG1438	arginine binding
DLE04_05335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DLE04_05340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DLE04_05345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DLE04_05350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLE04_05350	COG0072	phenylalanine-tRNA ligase activity
DLE04_05355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DLE04_05360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DLE04_05365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DLE04_05370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DLE04_05375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DLE04_05380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DLE04_05400	COG1132	(ABC) transporter
DLE04_05405	COG2151	metal-sulfur cluster biosynthetic enzyme
DLE04_05410	COG0822	iron-sulfur transferase activity
DLE04_05415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DLE04_05420	COG0396	ATPase activity
DLE04_05425	COG2146	nitrite reductase [NAD(P)H] activity
DLE04_05430	COG0719	Fe-S assembly protein
DLE04_05450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DLE04_05455	COG0166	Belongs to the GPI family
DLE04_05465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DLE04_05470	COG0149	triose-phosphate isomerase activity
DLE04_05475	COG0126	phosphoglycerate kinase activity
DLE04_05480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DLE04_05485	COG1481	regulation of sporulation
DLE04_05490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DLE04_05495	COG1660	Displays ATPase and GTPase activities
DLE04_05500	COG0322	excinuclease ABC activity
DLE04_05505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DLE04_05510	COG0556	nucleotide-excision repair
DLE04_05515	COG0237	dephospho-CoA kinase activity
DLE04_05515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DLE04_05520	COG0539	negative regulation of cytoplasmic translation
DLE04_05535	COG2050	protein possibly involved in aromatic compounds catabolism
DLE04_05585	COG0069	glutamate synthase activity
DLE04_05585	COG0067	glutamate synthase
DLE04_05585	COG0070	glutamate synthase
DLE04_05595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DLE04_05610	COG0159	tryptophan synthase activity
DLE04_05615	COG0133	tryptophan synthase activity
DLE04_05620	COG0134	indole-3-glycerol-phosphate synthase activity
DLE04_05625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DLE04_05630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DLE04_05635	COG0107	imidazoleglycerol-phosphate synthase activity
DLE04_05640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DLE04_05650	COG0131	Imidazoleglycerol-phosphate dehydratase
DLE04_05655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DLE04_05660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DLE04_05665	COG0587	DNA-directed DNA polymerase activity
DLE04_05675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DLE04_05685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DLE04_05695	COG1799	cell septum assembly
DLE04_05700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DLE04_05710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DLE04_05720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DLE04_05725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DLE04_05735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DLE04_05740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLE04_05745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DLE04_05750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DLE04_05765	COG0275	rRNA processing
DLE04_05770	COG2001	Belongs to the MraZ family
DLE04_05780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DLE04_05785	COG0587	DNA-directed DNA polymerase activity
DLE04_05800	COG0730	response to heat
DLE04_05815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DLE04_05825	COG0596	Alpha beta hydrolase
DLE04_05840	COG0463	Glycosyl transferase, family 2
DLE04_05850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DLE04_05880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DLE04_05880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DLE04_05885	COG0515	serine threonine protein kinase
DLE04_05885	COG2815	serine threonine protein kinase
DLE04_05890	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DLE04_05910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DLE04_05915	COG0205	6-phosphofructokinase activity
DLE04_05920	COG1070	Carbohydrate kinase
DLE04_05925	COG0697	spore germination
DLE04_05930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DLE04_05940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DLE04_05945	COG0681	Belongs to the peptidase S26 family
DLE04_05950	COG0335	large ribosomal subunit rRNA binding
DLE04_05965	COG2313	pseudouridylate synthase activity
DLE04_05970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE04_05975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DLE04_05980	COG0488	(ABC) transporter
DLE04_05995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DLE04_06005	COG1940	carbohydrate kinase activity
DLE04_06045	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_06050	COG0673	inositol 2-dehydrogenase activity
DLE04_06065	COG3254	rhamnose metabolic process
DLE04_06075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DLE04_06100	COG0395	ABC-type sugar transport system, permease component
DLE04_06105	COG1175	transmembrane transport
DLE04_06120	COG4948	Mandelate Racemase Muconate Lactonizing
DLE04_06135	COG4948	Mandelate Racemase Muconate Lactonizing
DLE04_06140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DLE04_06155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLE04_06160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DLE04_06170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DLE04_06190	COG1832	CoA-binding protein
DLE04_06200	COG0662	Cupin 2, conserved barrel domain protein
DLE04_06230	COG0395	ABC-type sugar transport system, permease component
DLE04_06245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLE04_06255	COG3254	rhamnose metabolic process
DLE04_06265	COG3347	Dehydrogenase
DLE04_06265	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_06270	COG1070	Carbohydrate kinase
DLE04_06290	COG1064	alcohol dehydrogenase
DLE04_06305	COG4608	Belongs to the ABC transporter superfamily
DLE04_06320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLE04_06335	COG2267	carboxylic ester hydrolase activity
DLE04_06340	COG3046	protein related to deoxyribodipyrimidine photolyase
DLE04_06360	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DLE04_06370	COG3962	Belongs to the TPP enzyme family
DLE04_06380	COG1744	ABC transporter substrate-binding protein PnrA-like
DLE04_06400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DLE04_06405	COG0402	S-adenosylhomocysteine deaminase activity
DLE04_06410	COG1028	Short-chain dehydrogenase reductase Sdr
DLE04_06425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLE04_06425	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DLE04_06430	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLE04_06455	COG0537	adenosine 5'-monophosphoramidase activity
DLE04_06460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DLE04_06465	COG0484	heat shock protein binding
DLE04_06470	COG1420	regulation of RNA biosynthetic process
DLE04_06485	COG0481	GTPase activity
DLE04_06490	COG0268	Binds directly to 16S ribosomal RNA
DLE04_06505	COG1555	photosystem II stabilization
DLE04_06505	COG1596	polysaccharide export
DLE04_06510	COG0495	leucyl-tRNA aminoacylation
DLE04_06530	COG0799	negative regulation of ribosome biogenesis
DLE04_06535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DLE04_06540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DLE04_06545	COG0482	sulfurtransferase activity
DLE04_06555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DLE04_06565	COG0438	transferase activity, transferring glycosyl groups
DLE04_06565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DLE04_06570	COG0438	transferase activity, transferring glycosyl groups
DLE04_06585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DLE04_06590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLE04_06620	COG1278	Cold shock
DLE04_06645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLE04_06660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE04_06670	COG3718	enzyme involved in inositol metabolism
DLE04_06680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLE04_06705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DLE04_06710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLE04_06720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DLE04_06730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLE04_06750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DLE04_06755	COG2949	membrane
DLE04_06765	COG0423	glycine-tRNA ligase activity
DLE04_06780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DLE04_06785	COG1381	Involved in DNA repair and RecF pathway recombination
DLE04_06790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLE04_06810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLE04_06810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DLE04_06815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DLE04_06835	COG3590	peptidase
DLE04_06840	COG1063	alcohol dehydrogenase
DLE04_06845	COG4608	Belongs to the ABC transporter superfamily
DLE04_06850	COG0444	Belongs to the ABC transporter superfamily
DLE04_06875	COG0477	Major facilitator Superfamily
DLE04_06880	COG0343	queuine tRNA-ribosyltransferase activity
DLE04_06900	COG1982	Orn Lys Arg decarboxylase major
DLE04_06915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DLE04_06920	COG0581	inorganic phosphate transmembrane transporter activity
DLE04_06935	COG5002	protein histidine kinase activity
DLE04_06945	COG0277	FAD linked oxidase domain protein
DLE04_06950	COG1968	undecaprenyl-diphosphatase activity
DLE04_06965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DLE04_07030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DLE04_07100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DLE04_07105	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DLE04_07110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DLE04_07115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DLE04_07120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DLE04_07125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DLE04_07130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DLE04_07135	COG0356	it plays a direct role in the translocation of protons across the membrane
DLE04_07150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLE04_07155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DLE04_07165	COG2890	protein-(glutamine-N5) methyltransferase activity
DLE04_07170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DLE04_07175	COG0254	rRNA binding
DLE04_07190	COG0083	homoserine kinase activity
DLE04_07195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DLE04_07200	COG0460	homoserine dehydrogenase
DLE04_07210	COG0018	arginyl-trna synthetase
DLE04_07255	COG2755	lipolytic protein G-D-S-L family
DLE04_07255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DLE04_07265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DLE04_07270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DLE04_07275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DLE04_07300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DLE04_07315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DLE04_07340	COG1741	Belongs to the pirin family