locus-tag	class	description
IPM43_00015	COG1960	acyl-CoA dehydrogenase activity
IPM43_00025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPM43_00035	COG1160	GTP binding
IPM43_00110	COG2135	peptidase activity
IPM43_00120	COG0537	adenosine 5'-monophosphoramidase activity
IPM43_00125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM43_00135	COG1716	ATPase activity
IPM43_00155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPM43_00165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM43_00165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPM43_00170	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_00190	COG2197	response regulator
IPM43_00210	COG2175	clavaminate synthase activity
IPM43_00230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPM43_00240	COG2264	protein methyltransferase activity
IPM43_00255	COG1024	Enoyl-CoA hydratase
IPM43_00275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IPM43_00285	COG0604	alcohol dehydrogenase
IPM43_00295	COG4581	dead DEAH box helicase
IPM43_00300	COG0805	protein transport
IPM43_00305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPM43_00310	COG0584	glycerophosphoryl diester phosphodiesterase
IPM43_00325	COG0681	Belongs to the peptidase S26 family
IPM43_00330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPM43_00335	COG1984	allophanate hydrolase subunit 2
IPM43_00345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IPM43_00355	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPM43_00360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPM43_00370	COG4122	O-methyltransferase activity
IPM43_00375	COG1222	aaa ATPase
IPM43_00390	COG0037	tRNA processing
IPM43_00445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPM43_00460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPM43_00505	COG1012	belongs to the aldehyde dehydrogenase family
IPM43_00515	COG0277	FAD linked oxidase domain protein
IPM43_00520	COG0277	FAD linked oxidase domain protein
IPM43_00540	COG0494	nUDIX hydrolase
IPM43_00545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPM43_00550	COG0124	histidyl-tRNA synthetase
IPM43_00555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPM43_00560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPM43_00565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM43_00570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM43_00575	COG1862	Preprotein translocase
IPM43_00580	COG0343	queuine tRNA-ribosyltransferase activity
IPM43_00585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPM43_00595	COG2255	four-way junction helicase activity
IPM43_00600	COG0632	four-way junction helicase activity
IPM43_00605	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPM43_00615	COG0217	transcriptional regulatory protein
IPM43_00620	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IPM43_00625	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IPM43_00635	COG0501	Belongs to the peptidase M48B family
IPM43_00640	COG1704	LemA family
IPM43_00645	COG0438	transferase activity, transferring glycosyl groups
IPM43_00655	COG0668	transmembrane transport
IPM43_00695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPM43_00700	COG0204	Acyl-transferase
IPM43_00700	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_00705	COG0215	cysteine-tRNA ligase activity
IPM43_00715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IPM43_00720	COG1331	Highly conserved protein containing a thioredoxin domain
IPM43_00730	COG0183	Belongs to the thiolase family
IPM43_00765	COG1959	2 iron, 2 sulfur cluster binding
IPM43_00770	COG0564	pseudouridine synthase activity
IPM43_00780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IPM43_00785	COG1872	DUF167
IPM43_00790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPM43_00805	COG1799	cell septum assembly
IPM43_00815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPM43_00820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IPM43_00825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPM43_00830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPM43_00835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPM43_00840	COG0772	Belongs to the SEDS family
IPM43_00845	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPM43_00850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM43_00855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPM43_00860	COG0768	penicillin binding
IPM43_00870	COG0275	rRNA processing
IPM43_00875	COG2001	Belongs to the MraZ family
IPM43_00880	COG0739	heme binding
IPM43_00885	COG0095	Lipoate-protein ligase
IPM43_00905	COG0714	Associated with various cellular activities
IPM43_00925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPM43_00930	COG1216	Glycosyl transferase, family 2
IPM43_00940	COG0483	inositol monophosphate 1-phosphatase activity
IPM43_00945	COG0745	RESPONSE REGULATOR receiver
IPM43_00960	COG0205	6-phosphofructokinase activity
IPM43_00970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM43_00980	COG0436	Aminotransferase
IPM43_00985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPM43_00990	COG1940	carbohydrate kinase activity
IPM43_01005	COG0438	transferase activity, transferring glycosyl groups
IPM43_01010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IPM43_01030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPM43_01035	COG0047	phosphoribosylformylglycinamidine synthase activity
IPM43_01040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IPM43_01045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IPM43_01055	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPM43_01060	COG0517	IMP dehydrogenase activity
IPM43_01060	COG0516	GMP reductase activity
IPM43_01075	COG0464	growth
IPM43_01085	COG0728	peptidoglycan biosynthetic process
IPM43_01090	COG1842	Phage shock protein A
IPM43_01095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IPM43_01100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPM43_01105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IPM43_01110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPM43_01120	COG1530	ribonuclease E activity
IPM43_01135	COG0772	Belongs to the SEDS family
IPM43_01140	COG0768	penicillin binding
IPM43_01150	COG1792	Involved in formation and maintenance of cell shape
IPM43_01160	COG0105	UTP biosynthetic process
IPM43_01165	COG0285	dihydrofolate synthase activity
IPM43_01170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPM43_01175	COG0740	serine-type endopeptidase activity
IPM43_01180	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPM43_01215	COG1653	transport
IPM43_01225	COG2326	polyphosphate kinase activity
IPM43_01235	COG0671	phosphoesterase, PA-phosphatase related
IPM43_01245	COG2326	polyphosphate kinase activity
IPM43_01255	COG0628	permease
IPM43_01275	COG0386	Belongs to the glutathione peroxidase family
IPM43_01310	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_01315	COG2205	protein histidine kinase activity
IPM43_01320	COG0745	RESPONSE REGULATOR receiver
IPM43_01335	COG1960	acyl-CoA dehydrogenase activity
IPM43_01340	COG0596	Alpha beta hydrolase
IPM43_01340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPM43_01350	COG1960	acyl-CoA dehydrogenase activity
IPM43_01365	COG1366	Belongs to the anti-sigma-factor antagonist family
IPM43_01390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IPM43_01440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IPM43_01460	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_01465	COG2193	ferroxidase activity
IPM43_01475	COG1121	(ABC) transporter
IPM43_01480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPM43_01490	COG2124	cytochrome p450
IPM43_01495	COG2084	Dehydrogenase
IPM43_01500	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_01535	COG0589	response to stress
IPM43_01560	COG2072	flavoprotein involved in K transport
IPM43_01570	COG1546	Belongs to the CinA family
IPM43_01570	COG1058	Belongs to the CinA family
IPM43_01580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM43_01590	COG1674	ftsk spoiiie
IPM43_01595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPM43_01600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPM43_01610	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPM43_01650	COG0070	glutamate synthase
IPM43_01650	COG0069	glutamate synthase activity
IPM43_01650	COG0067	glutamate synthase
IPM43_01660	COG1024	Enoyl-CoA hydratase
IPM43_01665	COG2188	Transcriptional regulator
IPM43_01670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPM43_01675	COG0778	Nitroreductase
IPM43_01690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM43_01695	COG0372	Belongs to the citrate synthase family
IPM43_01705	COG1404	Belongs to the peptidase S8 family
IPM43_01710	COG1063	alcohol dehydrogenase
IPM43_01720	COG1960	acyl-CoA dehydrogenase activity
IPM43_01735	COG0667	Aldo Keto reductase
IPM43_01860	COG4695	Portal protein
IPM43_01995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IPM43_02000	COG0484	heat shock protein binding
IPM43_02005	COG1420	regulation of RNA biosynthetic process
IPM43_02010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IPM43_02025	COG0268	Binds directly to 16S ribosomal RNA
IPM43_02075	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_02080	COG0495	leucyl-tRNA aminoacylation
IPM43_02100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM43_02100	COG2755	lipolytic protein G-D-S-L family
IPM43_02125	COG1131	(ABC) transporter
IPM43_02135	COG0114	fumarate hydratase activity
IPM43_02155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM43_02170	COG0799	negative regulation of ribosome biogenesis
IPM43_02180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPM43_02185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPM43_02190	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IPM43_02205	COG0183	Belongs to the thiolase family
IPM43_02215	COG1435	thymidine kinase activity
IPM43_02225	COG2843	Capsule synthesis protein
IPM43_02230	COG1793	dna ligase
IPM43_02240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPM43_02245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPM43_02255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPM43_02270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPM43_02275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPM43_02280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPM43_02285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPM43_02290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPM43_02295	COG0358	DNA primase activity
IPM43_02305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPM43_02305	COG0574	Belongs to the PEP-utilizing enzyme family
IPM43_02315	COG0354	folic acid binding
IPM43_02325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IPM43_02330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPM43_02340	COG0667	Aldo Keto reductase
IPM43_02345	COG2040	homocysteine
IPM43_02350	COG0107	imidazoleglycerol-phosphate synthase activity
IPM43_02355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IPM43_02360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPM43_02365	COG0131	Imidazoleglycerol-phosphate dehydratase
IPM43_02370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPM43_02380	COG0456	acetyltransferase
IPM43_02390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPM43_02420	COG1119	ATPase activity
IPM43_02450	COG0484	heat shock protein binding
IPM43_02455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPM43_02465	COG1176	ABC-type spermidine putrescine transport system, permease component I
IPM43_02470	COG3842	ATPase activity
IPM43_02480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IPM43_02485	COG1012	belongs to the aldehyde dehydrogenase family
IPM43_02490	COG0686	Belongs to the AlaDH PNT family
IPM43_02500	COG0167	dihydroorotate dehydrogenase activity
IPM43_02505	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPM43_02505	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPM43_02505	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPM43_02505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPM43_02520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPM43_02540	COG0765	amino acid transport
IPM43_02570	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_02580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPM43_02590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPM43_02600	COG0612	Peptidase, M16
IPM43_02605	COG1185	polyribonucleotide nucleotidyltransferase activity
IPM43_02610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPM43_02620	COG4176	ABC-type proline glycine betaine transport system permease component
IPM43_02625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IPM43_02630	COG0196	riboflavin kinase activity
IPM43_02635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPM43_02640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPM43_02645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPM43_02655	COG0195	Participates in both transcription termination and antitermination
IPM43_02665	COG0442	prolyl-tRNA aminoacylation
IPM43_02685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPM43_02690	COG0750	zinc metalloprotease
IPM43_02695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IPM43_02700	COG4589	Belongs to the CDS family
IPM43_02705	COG0233	cytoplasmic translational termination
IPM43_02710	COG0528	UMP kinase activity
IPM43_02715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPM43_02720	COG0052	Belongs to the universal ribosomal protein uS2 family
IPM43_02730	COG1191	sigma factor activity
IPM43_02735	COG4974	Belongs to the 'phage' integrase family
IPM43_02740	COG0758	DNA mediated transformation
IPM43_02755	COG0740	serine-type endopeptidase activity
IPM43_02780	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_02800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPM43_02805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPM43_02810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPM43_02835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPM43_02840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IPM43_02845	COG5001	Diguanylate cyclase
IPM43_02845	COG3300	MHYT domain
IPM43_02920	COG1573	uracil-dna glycosylase
IPM43_02950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPM43_02955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IPM43_02965	COG2066	Belongs to the glutaminase family
IPM43_03000	COG0659	secondary active sulfate transmembrane transporter activity
IPM43_03045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPM43_03065	COG3119	arylsulfatase activity
IPM43_03070	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IPM43_03095	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_03110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM43_03125	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_03155	COG1288	antiporter activity
IPM43_03205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_03245	COG1132	(ABC) transporter
IPM43_03250	COG1132	(ABC) transporter
IPM43_03255	COG2353	YceI-like domain
IPM43_03260	COG3384	dioxygenase
IPM43_03305	COG2070	2-Nitropropane dioxygenase
IPM43_03310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPM43_03315	COG2175	clavaminate synthase activity
IPM43_03320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPM43_03335	COG2366	antibiotic biosynthetic process
IPM43_03340	COG3033	Beta-eliminating lyase
IPM43_03350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM43_03365	COG0788	formyltetrahydrofolate deformylase activity
IPM43_03370	COG1024	Enoyl-CoA hydratase
IPM43_03375	COG2177	Part of the ABC transporter FtsEX involved in
IPM43_03380	COG2884	Cell division ATP-binding protein ftsE
IPM43_03385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPM43_03390	COG0653	protein targeting
IPM43_03395	COG1040	competence protein
IPM43_03405	COG2364	Membrane
IPM43_03410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPM43_03420	COG2835	tetraacyldisaccharide 4'-kinase activity
IPM43_03445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPM43_03480	COG0438	transferase activity, transferring glycosyl groups
IPM43_03485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPM43_03490	COG0778	Nitroreductase
IPM43_03490	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IPM43_03495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM43_03500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPM43_03515	COG0438	transferase activity, transferring glycosyl groups
IPM43_03530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM43_03545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPM43_03555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM43_03565	COG0776	regulation of translation
IPM43_03575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IPM43_03580	COG1199	ATP-dependent helicase activity
IPM43_03580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IPM43_03590	COG2378	regulation of single-species biofilm formation
IPM43_03595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM43_03595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM43_03600	COG3540	Alkaline phosphatase
IPM43_03605	COG0166	Belongs to the GPI family
IPM43_03615	COG2962	Rard protein
IPM43_03640	COG0559	Belongs to the binding-protein-dependent transport system permease family
IPM43_03660	COG0248	Ppx GppA phosphatase
IPM43_03670	COG1215	transferase activity, transferring glycosyl groups
IPM43_03685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPM43_03705	COG0569	domain protein
IPM43_03710	COG0531	amino acid
IPM43_03725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IPM43_03740	COG0328	RNA-DNA hybrid ribonuclease activity
IPM43_03745	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IPM43_03780	COG0438	transferase activity, transferring glycosyl groups
IPM43_03805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPM43_03820	COG1134	teichoic acid transport
IPM43_03855	COG2755	lipolytic protein G-D-S-L family
IPM43_03855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM43_03860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPM43_03875	COG1960	acyl-CoA dehydrogenase activity
IPM43_03900	COG1024	Enoyl-CoA hydratase
IPM43_03910	COG0396	ATPase activity
IPM43_03915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPM43_03920	COG0822	iron-sulfur transferase activity
IPM43_03925	COG0442	prolyl-tRNA aminoacylation
IPM43_03935	COG0396	ATPase activity
IPM43_03940	COG2146	nitrite reductase [NAD(P)H] activity
IPM43_03945	COG0719	Fe-S assembly protein
IPM43_03990	COG1234	tRNA 3'-trailer cleavage
IPM43_03995	COG0596	Alpha beta hydrolase
IPM43_04015	COG2030	dehydratase
IPM43_04040	COG2301	Belongs to the HpcH HpaI aldolase family
IPM43_04045	COG2301	Belongs to the HpcH HpaI aldolase family
IPM43_04055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IPM43_04060	COG2032	superoxide dismutase activity
IPM43_04065	COG0574	Belongs to the PEP-utilizing enzyme family
IPM43_04065	COG3848	Pyruvate phosphate dikinase
IPM43_04080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IPM43_04090	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IPM43_04095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IPM43_04110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM43_04120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPM43_04140	COG1643	Atp-dependent helicase
IPM43_04145	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IPM43_04145	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IPM43_04165	COG0488	(ABC) transporter
IPM43_04180	COG2409	Drug exporters of the RND superfamily
IPM43_04220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_04235	COG2124	cytochrome p450
IPM43_04250	COG1024	Enoyl-CoA hydratase
IPM43_04295	COG2124	cytochrome p450
IPM43_04300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM43_04305	COG1960	acyl-CoA dehydrogenase activity
IPM43_04310	COG1902	pentaerythritol trinitrate reductase activity
IPM43_04325	COG0183	Belongs to the thiolase family
IPM43_04330	COG0243	molybdopterin cofactor binding
IPM43_04355	COG1335	isochorismatase
IPM43_04400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM43_04410	COG1024	Enoyl-CoA hydratase
IPM43_04465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_04470	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_04485	COG1960	acyl-CoA dehydrogenase activity
IPM43_04490	COG1960	acyl-CoA dehydrogenase activity
IPM43_04520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IPM43_04525	COG1960	acyl-CoA dehydrogenase activity
IPM43_04535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM43_04540	COG1309	transcriptional regulator
IPM43_04565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPM43_04570	COG2902	Dehydrogenase
IPM43_04575	COG1024	Enoyl-CoA hydratase
IPM43_04585	COG1960	acyl-CoA dehydrogenase activity
IPM43_04590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM43_04595	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM43_04600	COG0022	dehydrogenase e1 component
IPM43_04600	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM43_04605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IPM43_04610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM43_04625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPM43_04630	COG0010	Belongs to the arginase family
IPM43_04640	COG0473	3-isopropylmalate dehydrogenase activity
IPM43_04645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPM43_04650	COG2267	carboxylic ester hydrolase activity
IPM43_04660	COG0157	Belongs to the NadC ModD family
IPM43_04665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IPM43_04685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IPM43_04690	COG0066	3-isopropylmalate dehydratase activity
IPM43_04715	COG1136	(ABC) transporter
IPM43_04715	COG0577	efflux transmembrane transporter activity
IPM43_04780	COG3273	potassium ion transport
IPM43_04780	COG0471	metal ion transport
IPM43_04790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPM43_04800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM43_04805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPM43_04820	COG0284	orotidine-5'-phosphate decarboxylase activity
IPM43_04835	COG4948	Mandelate Racemase Muconate Lactonizing
IPM43_04850	COG0477	Major facilitator Superfamily
IPM43_04855	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_04870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPM43_04885	COG0482	sulfurtransferase activity
IPM43_04890	COG1104	cysteine desulfurase activity
IPM43_04895	COG2226	methyltransferase
IPM43_04900	COG1085	galactose-1-phosphate uridylyltransferase
IPM43_04920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IPM43_04930	COG0058	SHG alpha-glucan phosphorylase activity
IPM43_04935	COG1024	Enoyl-CoA hydratase
IPM43_04945	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IPM43_04960	COG0477	Major facilitator Superfamily
IPM43_04990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPM43_04995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM43_05010	COG0300	oxidoreductase activity
IPM43_05015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPM43_05020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPM43_05025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPM43_05030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPM43_05035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM43_05050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPM43_05055	COG0356	it plays a direct role in the translocation of protons across the membrane
IPM43_05075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPM43_05080	COG0698	ribose 5-phosphate isomerase
IPM43_05100	COG1063	alcohol dehydrogenase
IPM43_05120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPM43_05160	COG0460	homoserine dehydrogenase
IPM43_05180	COG0018	arginyl-trna synthetase
IPM43_05200	COG2801	Transposase and inactivated derivatives
IPM43_05200	COG3415	Transposase
IPM43_05230	COG1203	CRISPR-associated helicase, Cas3
IPM43_05255	COG1518	maintenance of DNA repeat elements
IPM43_05300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPM43_05305	COG0640	Transcriptional regulator
IPM43_05325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IPM43_05325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IPM43_05330	COG1215	transferase activity, transferring glycosyl groups
IPM43_05390	COG2226	methyltransferase
IPM43_05450	COG0438	transferase activity, transferring glycosyl groups
IPM43_05490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPM43_05510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM43_05515	COG2826	transposase and inactivated derivatives, IS30 family
IPM43_05525	COG2372	response to copper ion
IPM43_05560	COG1024	Enoyl-CoA hydratase
IPM43_05570	COG1960	acyl-CoA dehydrogenase activity
IPM43_05580	COG0475	glutathione-regulated potassium exporter activity
IPM43_05585	COG0004	ammonium transporteR
IPM43_05625	COG0406	alpha-ribazole phosphatase activity
IPM43_05645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPM43_05655	COG1597	lipid kinase activity
IPM43_05695	COG2151	metal-sulfur cluster biosynthetic enzyme
IPM43_05695	COG0489	protein tyrosine kinase activity
IPM43_05720	COG4235	cytochrome complex assembly
IPM43_05720	COG3088	subunit of a heme lyase
IPM43_05725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM43_05730	COG1138	Cytochrome C-type biogenesis protein
IPM43_05735	COG1138	Cytochrome C-type biogenesis protein
IPM43_05740	COG1138	Cytochrome C-type biogenesis protein
IPM43_05745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IPM43_05755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPM43_05785	COG1024	Enoyl-CoA hydratase
IPM43_05825	COG1946	Acyl-CoA thioesterase
IPM43_05840	COG1024	Enoyl-CoA hydratase
IPM43_05845	COG1077	Cell shape determining protein MreB Mrl
IPM43_05855	COG0314	molybdopterin synthase activity
IPM43_05875	COG2814	Major facilitator Superfamily
IPM43_05880	COG0745	RESPONSE REGULATOR receiver
IPM43_05885	COG5002	protein histidine kinase activity
IPM43_05890	COG0704	Plays a role in the regulation of phosphate uptake
IPM43_05895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IPM43_05905	COG0573	inorganic phosphate transmembrane transporter activity
IPM43_05910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IPM43_05935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPM43_05955	COG0813	purine-nucleoside phosphorylase activity
IPM43_05965	COG0039	L-malate dehydrogenase activity
IPM43_05970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM43_05970	COG2755	lipolytic protein G-D-S-L family
IPM43_05980	COG0138	bifunctional purine biosynthesis protein purh
IPM43_05990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IPM43_05995	COG0045	succinate-CoA ligase (ADP-forming) activity
IPM43_06020	COG0210	DNA helicase
IPM43_06030	COG2205	protein histidine kinase activity
IPM43_06050	COG3022	response to hydroperoxide
IPM43_06055	COG1131	(ABC) transporter
IPM43_06085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPM43_06085	COG0519	Catalyzes the synthesis of GMP from XMP
IPM43_06105	COG0494	nUDIX hydrolase
IPM43_06130	COG0459	protein refolding
IPM43_06140	COG0424	maF-like protein
IPM43_06150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPM43_06160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPM43_06170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPM43_06175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPM43_06175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPM43_06180	COG0736	holo-[acyl-carrier-protein] synthase activity
IPM43_06185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPM43_06190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM43_06195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPM43_06200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPM43_06205	COG0561	phosphatase activity
IPM43_06205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPM43_06210	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IPM43_06220	COG5002	protein histidine kinase activity
IPM43_06230	COG0101	tRNA pseudouridine synthase activity
IPM43_06235	COG0203	ribosomal protein L17
IPM43_06240	COG0202	RNA polymerase activity
IPM43_06245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPM43_06250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPM43_06255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPM43_06270	COG0563	adenylate kinase activity
IPM43_06280	COG0200	Binds to the 23S rRNA
IPM43_06285	COG1841	ribosomal large subunit assembly
IPM43_06290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPM43_06295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPM43_06300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPM43_06305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPM43_06310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPM43_06315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPM43_06320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPM43_06325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPM43_06330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPM43_06335	COG0255	Belongs to the universal ribosomal protein uL29 family
IPM43_06340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPM43_06345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPM43_06350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPM43_06355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPM43_06360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPM43_06365	COG0089	rRNA binding
IPM43_06370	COG0088	Forms part of the polypeptide exit tunnel
IPM43_06375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPM43_06380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IPM43_06385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM43_06390	COG0051	transcription antitermination factor activity, RNA binding
IPM43_06395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM43_06400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPM43_06415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPM43_06420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPM43_06425	COG0085	RNA polymerase activity
IPM43_06435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPM43_06440	COG0081	regulation of translation
IPM43_06445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPM43_06450	COG0250	Participates in transcription elongation, termination and antitermination
IPM43_06465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPM43_06470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPM43_06495	COG1666	GTP binding
IPM43_06510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPM43_06520	COG1007	ATP synthesis coupled electron transport
IPM43_06530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPM43_06535	COG0713	ATP synthesis coupled electron transport
IPM43_06540	COG0839	Belongs to the complex I subunit 6 family
IPM43_06545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM43_06550	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPM43_06555	COG0649	NAD binding
IPM43_06560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM43_06565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM43_06570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM43_06580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM43_06585	COG0519	Catalyzes the synthesis of GMP from XMP
IPM43_06585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPM43_06590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPM43_06600	COG1473	amidohydrolase
IPM43_06610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IPM43_06625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IPM43_06700	COG1215	transferase activity, transferring glycosyl groups
IPM43_06730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPM43_06740	COG1960	acyl-CoA dehydrogenase activity
IPM43_06745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM43_06760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM43_06770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM43_06780	COG0366	Alpha amylase catalytic
IPM43_06785	COG3833	ABC-type maltose transport systems, permease component
IPM43_06790	COG1175	transmembrane transport
IPM43_06800	COG1609	Transcriptional regulator
IPM43_06810	COG0346	lactoylglutathione lyase activity
IPM43_06830	COG0210	DNA helicase
IPM43_06840	COG3259	Nickel-dependent hydrogenase
IPM43_06865	COG0657	acetylesterase activity
IPM43_06895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPM43_06915	COG3214	Protein conserved in bacteria
IPM43_06925	COG1653	transport
IPM43_06935	COG1175	transmembrane transport
IPM43_06940	COG3842	ATPase activity
IPM43_06955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPM43_06960	COG2267	carboxylic ester hydrolase activity
IPM43_06990	COG4552	Acetyltransferase involved in intracellular survival and related
IPM43_07020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPM43_07065	COG0756	dUTP diphosphatase activity
IPM43_07110	COG0259	pyridoxamine-phosphate oxidase activity
IPM43_07115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPM43_07120	COG1131	(ABC) transporter
IPM43_07145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPM43_07150	COG1565	acr, cog1565
IPM43_07150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPM43_07165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPM43_07170	COG0109	protoheme IX farnesyltransferase activity
IPM43_07175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPM43_07215	COG1024	Enoyl-CoA hydratase
IPM43_07225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPM43_07235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPM43_07240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPM43_07245	COG0745	RESPONSE REGULATOR receiver
IPM43_07255	COG0542	response to heat
IPM43_07265	COG0789	Transcriptional regulator
IPM43_07270	COG0484	heat shock protein binding
IPM43_07275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPM43_07280	COG0443	Heat shock 70 kDa protein
IPM43_07310	COG0642	Histidine kinase
IPM43_07320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IPM43_07330	COG0588	phosphoglycerate mutase activity
IPM43_07340	COG0247	lactate metabolic process
IPM43_07340	COG2181	nitrate reductase activity
IPM43_07345	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_07360	COG0717	Belongs to the dCTP deaminase family
IPM43_07395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IPM43_07425	COG0305	Participates in initiation and elongation during chromosome replication
IPM43_07430	COG0359	binds to the 23S rRNA
IPM43_07435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPM43_07445	COG0360	Binds together with S18 to 16S ribosomal RNA
IPM43_07470	COG5001	Diguanylate cyclase
IPM43_07475	COG0617	tRNA 3'-terminal CCA addition
IPM43_07485	COG0456	acetyltransferase
IPM43_07495	COG1307	EDD domain protein, DegV family
IPM43_07500	COG0515	serine threonine protein kinase
IPM43_07520	COG0492	ferredoxin-NADP+ reductase activity
IPM43_07525	COG3118	belongs to the thioredoxin family
IPM43_07525	COG0492	ferredoxin-NADP+ reductase activity
IPM43_07540	COG1192	Involved in chromosome partitioning
IPM43_07545	COG0357	Ribosomal RNA small subunit methyltransferase G
IPM43_07555	COG0706	membrane insertase activity
IPM43_07560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPM43_07565	COG0594	ribonuclease P activity
IPM43_07570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPM43_07575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPM43_07580	COG0592	DNA-directed DNA polymerase activity
IPM43_07585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPM43_07590	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IPM43_07595	COG0187	DNA topoisomerase II activity
IPM43_07635	COG2239	Acts as a magnesium transporter
IPM43_07680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IPM43_07700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPM43_07710	COG1022	Amp-dependent synthetase and ligase
IPM43_07715	COG0183	Belongs to the thiolase family
IPM43_07740	COG0515	serine threonine protein kinase
IPM43_07740	COG2815	serine threonine protein kinase
IPM43_07745	COG0768	penicillin binding
IPM43_07755	COG0631	protein serine/threonine phosphatase activity
IPM43_07835	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_07845	COG3858	chitin binding
IPM43_07845	COG1388	LysM domain
IPM43_07860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPM43_07875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IPM43_07875	COG2146	nitrite reductase [NAD(P)H] activity
IPM43_07885	COG1131	(ABC) transporter
IPM43_07895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IPM43_07905	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IPM43_07910	COG1691	(AIR) carboxylase
IPM43_07915	COG0077	Prephenate dehydratase
IPM43_07925	COG2755	lipolytic protein G-D-S-L family
IPM43_07925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM43_07950	COG2318	DinB family
IPM43_07995	COG1230	cation diffusion facilitator family transporter
IPM43_08015	COG0488	(ABC) transporter
IPM43_08050	COG0596	Alpha beta hydrolase
IPM43_08060	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IPM43_08070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPM43_08080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM43_08080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM43_08090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPM43_08105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM43_08125	COG1131	(ABC) transporter
IPM43_08140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM43_08145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM43_08150	COG0436	Aminotransferase
IPM43_08175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM43_08180	COG2968	Membrane
IPM43_08185	COG1793	dna ligase
IPM43_08200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPM43_08205	COG0183	Belongs to the thiolase family
IPM43_08210	COG0604	alcohol dehydrogenase
IPM43_08215	COG0346	lactoylglutathione lyase activity
IPM43_08235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPM43_08240	COG0494	nUDIX hydrolase
IPM43_08260	COG1473	amidohydrolase
IPM43_08265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IPM43_08295	COG1072	(Pantothenic acid kinase))
IPM43_08365	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IPM43_08395	COG3842	ATPase activity
IPM43_08400	COG1178	ABC-type Fe3 transport system permease component
IPM43_08420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPM43_08445	COG0037	tRNA processing
IPM43_08465	COG1595	DNA-templated transcription, initiation
IPM43_08470	COG1846	Transcriptional regulator
IPM43_08500	COG0488	(ABC) transporter
IPM43_08520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPM43_08525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPM43_08525	COG1754	DNA topoisomerase type I activity
IPM43_08535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IPM43_08555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IPM43_08575	COG1459	type II secretion system
IPM43_08580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPM43_08590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM43_08590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPM43_08635	COG1132	(ABC) transporter
IPM43_08655	COG0142	geranyltranstransferase activity
IPM43_08680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM43_08680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM43_08685	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPM43_08710	COG0527	aspartate kinase activity
IPM43_08730	COG1595	DNA-templated transcription, initiation
IPM43_08750	COG2894	cell division
IPM43_08780	COG3030	protein affecting phage T7 exclusion by the F plasmid
IPM43_08785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM43_08790	COG1937	Protein conserved in bacteria
IPM43_08815	COG2080	2 iron, 2 sulfur cluster binding
IPM43_08840	COG2119	membrane
IPM43_08845	COG0745	RESPONSE REGULATOR receiver
IPM43_08865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IPM43_08865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IPM43_08870	COG0406	alpha-ribazole phosphatase activity
IPM43_08890	COG0438	transferase activity, transferring glycosyl groups
IPM43_08900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IPM43_08905	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
IPM43_08910	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_08920	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IPM43_08925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IPM43_08930	COG0181	hydroxymethylbilane synthase activity
IPM43_08950	COG0113	porphobilinogen synthase activity
IPM43_08955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPM43_09015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM43_09020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM43_09025	COG0649	NAD binding
IPM43_09040	COG1034	ATP synthesis coupled electron transport
IPM43_09045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPM43_09050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPM43_09060	COG0713	ATP synthesis coupled electron transport
IPM43_09065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPM43_09080	COG0427	acetyl-CoA hydrolase
IPM43_09090	COG1024	Enoyl-CoA hydratase
IPM43_09095	COG1937	Protein conserved in bacteria
IPM43_09115	COG1674	ftsk spoiiie
IPM43_09125	COG1174	glycine betaine transport
IPM43_09140	COG1131	(ABC) transporter
IPM43_09185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPM43_09210	COG0572	uridine kinase
IPM43_09225	COG1929	Belongs to the glycerate kinase type-1 family
IPM43_09240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPM43_09245	COG0459	protein refolding
IPM43_09265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IPM43_09270	COG3253	May function as heme-dependent peroxidase
IPM43_09280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPM43_09290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IPM43_09295	COG1051	belongs to the nudix hydrolase family
IPM43_09345	COG1615	UPF0182 protein
IPM43_09375	COG0582	viral genome integration into host DNA
IPM43_09390	COG1475	DNA binding
IPM43_09405	COG4585	Histidine kinase
IPM43_09410	COG2197	response regulator
IPM43_09435	COG2026	Addiction module toxin, RelE StbE family
IPM43_09440	COG2197	response regulator
IPM43_09455	COG0742	ribosomal rna small subunit methyltransferase
IPM43_09540	COG1960	acyl-CoA dehydrogenase activity
IPM43_09545	COG3311	Transcriptional regulator
IPM43_09575	COG0577	efflux transmembrane transporter activity
IPM43_09575	COG1136	(ABC) transporter
IPM43_09580	COG1136	(ABC) transporter
IPM43_09580	COG0577	efflux transmembrane transporter activity
IPM43_09680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPM43_09695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM43_09700	COG3119	arylsulfatase activity
IPM43_09705	COG2197	response regulator
IPM43_09710	COG3851	Histidine kinase
IPM43_09735	COG1819	glycosyl
IPM43_09755	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IPM43_09780	COG2409	Drug exporters of the RND superfamily
IPM43_09805	COG0438	transferase activity, transferring glycosyl groups
IPM43_09845	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_09850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM43_09870	COG1472	Belongs to the glycosyl hydrolase 3 family
IPM43_09915	COG2826	transposase and inactivated derivatives, IS30 family
IPM43_09950	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_09960	COG1136	(ABC) transporter
IPM43_09980	COG2197	response regulator
IPM43_10000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPM43_10000	COG2111	Na H antiporter
IPM43_10005	COG2111	Na H antiporter
IPM43_10010	COG1006	Multisubunit Na H antiporter MnhC subunit
IPM43_10015	COG0651	ATP synthesis coupled electron transport
IPM43_10020	COG1863	multisubunit Na H antiporter MnhE subunit
IPM43_10025	COG2212	antiporter activity
IPM43_10030	COG1320	monovalent cation:proton antiporter activity
IPM43_10050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPM43_10055	COG0471	metal ion transport
IPM43_10055	COG3273	potassium ion transport
IPM43_10075	COG2226	methyltransferase
IPM43_10150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPM43_10160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IPM43_10180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPM43_10205	COG2072	flavoprotein involved in K transport
IPM43_10235	COG0535	radical SAM domain protein
IPM43_10245	COG2151	metal-sulfur cluster biosynthetic enzyme
IPM43_10260	COG0346	lactoylglutathione lyase activity
IPM43_10265	COG1643	Atp-dependent helicase
IPM43_10275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPM43_10290	COG0598	Magnesium transport protein CorA
IPM43_10295	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPM43_10300	COG0586	Pfam SNARE associated Golgi protein
IPM43_10310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_10325	COG0513	Belongs to the DEAD box helicase family
IPM43_10355	COG0306	phosphate transporter
IPM43_10365	COG2072	flavoprotein involved in K transport
IPM43_10385	COG1131	(ABC) transporter
IPM43_10400	COG4263	nitrous-oxide reductase activity
IPM43_10420	COG0156	8-amino-7-oxononanoate synthase activity
IPM43_10425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPM43_10440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IPM43_10460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPM43_10465	COG0419	ATPase involved in DNA repair
IPM43_10470	COG0420	3'-5' exonuclease activity
IPM43_10505	COG0559	Belongs to the binding-protein-dependent transport system permease family
IPM43_10510	COG1137	ATPase activity
IPM43_10535	COG1012	belongs to the aldehyde dehydrogenase family
IPM43_10555	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IPM43_10560	COG0175	sulfate reduction
IPM43_10565	COG1648	precorrin-2 dehydrogenase activity
IPM43_10565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPM43_10570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPM43_10570	COG1648	precorrin-2 dehydrogenase activity
IPM43_10590	COG3119	arylsulfatase activity
IPM43_10615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IPM43_10635	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IPM43_10660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPM43_10665	COG1960	acyl-CoA dehydrogenase activity
IPM43_10690	COG4689	acetoacetate decarboxylase
IPM43_10700	COG2321	neutral zinc metallopeptidase
IPM43_10760	COG0644	oxidoreductase
IPM43_10765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPM43_10775	COG0477	Major facilitator Superfamily
IPM43_10785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IPM43_10790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IPM43_10795	COG1902	pentaerythritol trinitrate reductase activity
IPM43_10795	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPM43_10800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IPM43_10805	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPM43_10805	COG1902	pentaerythritol trinitrate reductase activity
IPM43_10815	COG0535	radical SAM domain protein
IPM43_10825	COG3973	AAA domain
IPM43_10845	COG0714	Associated with various cellular activities
IPM43_10855	COG1316	TRANSCRIPTIONal
IPM43_10860	COG0525	valine-tRNA ligase activity
IPM43_10865	COG0215	cysteine-tRNA ligase activity
IPM43_10885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPM43_10930	COG1053	succinate dehydrogenase
IPM43_10935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPM43_10945	COG0730	response to heat
IPM43_10970	COG1960	acyl-CoA dehydrogenase activity
IPM43_10985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPM43_10995	COG0500	methyltransferase
IPM43_11020	COG0438	transferase activity, transferring glycosyl groups
IPM43_11025	COG0463	Glycosyl transferase, family 2
IPM43_11030	COG0463	Glycosyl transferase, family 2
IPM43_11070	COG0577	efflux transmembrane transporter activity
IPM43_11070	COG1136	(ABC) transporter
IPM43_11075	COG1136	(ABC) transporter
IPM43_11075	COG0577	efflux transmembrane transporter activity
IPM43_11080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IPM43_11095	COG0450	alkyl hydroperoxide reductase
IPM43_11120	COG1278	Cold shock
IPM43_11135	COG0210	DNA helicase
IPM43_11170	COG1490	D-aminoacyl-tRNA deacylase activity
IPM43_11175	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPM43_11185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IPM43_11190	COG3228	Belongs to the MtfA family
IPM43_11195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IPM43_11200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IPM43_11205	COG1999	signal sequence binding
IPM43_11215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPM43_11220	COG0501	Belongs to the peptidase M48B family
IPM43_11230	COG1309	transcriptional regulator
IPM43_11240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPM43_11250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM43_11255	COG0154	amidase activity
IPM43_11260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPM43_11265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IPM43_11265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IPM43_11275	COG0463	Glycosyl transferase, family 2
IPM43_11285	COG1960	acyl-CoA dehydrogenase activity
IPM43_11295	COG0183	Belongs to the thiolase family
IPM43_11300	COG2124	cytochrome p450
IPM43_11315	COG1960	acyl-CoA dehydrogenase activity
IPM43_11325	COG1960	acyl-CoA dehydrogenase activity
IPM43_11345	COG1024	Enoyl-CoA hydratase
IPM43_11380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM43_11410	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_11415	COG1902	pentaerythritol trinitrate reductase activity
IPM43_11415	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPM43_11420	COG1024	Enoyl-CoA hydratase
IPM43_11435	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11440	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_11445	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11465	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11475	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11485	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11490	COG1960	acyl-CoA dehydrogenase activity
IPM43_11495	COG1960	acyl-CoA dehydrogenase activity
IPM43_11515	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11520	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_11565	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IPM43_11580	COG1960	acyl-CoA dehydrogenase activity
IPM43_11585	COG1960	acyl-CoA dehydrogenase activity
IPM43_11590	COG2755	lipolytic protein G-D-S-L family
IPM43_11590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM43_11595	COG2210	Belongs to the sulfur carrier protein TusA family
IPM43_11600	COG2920	part of a sulfur-relay system
IPM43_11620	COG0183	Belongs to the thiolase family
IPM43_11650	COG1355	regulation of microtubule-based process
IPM43_11670	COG1024	Enoyl-CoA hydratase
IPM43_11680	COG1960	acyl-CoA dehydrogenase activity
IPM43_11685	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11695	COG0129	dihydroxy-acid dehydratase activity
IPM43_11710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPM43_11720	COG0440	acetolactate synthase activity
IPM43_11725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IPM43_11740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IPM43_11750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IPM43_11755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IPM43_11760	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IPM43_11770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IPM43_11775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPM43_11780	COG1120	ATPase activity
IPM43_11815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPM43_11820	COG3842	ATPase activity
IPM43_11825	COG4208	sulfate ABC transporter
IPM43_11860	COG2826	transposase and inactivated derivatives, IS30 family
IPM43_11865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IPM43_11875	COG0483	inositol monophosphate 1-phosphatase activity
IPM43_11885	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_11905	COG0312	modulator of DNA gyrase
IPM43_11910	COG0312	modulator of DNA gyrase
IPM43_11925	COG1968	undecaprenyl-diphosphatase activity
IPM43_11940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPM43_11955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPM43_11965	COG0315	cyclic pyranopterin monophosphate synthase activity
IPM43_11990	COG1733	regulation of RNA biosynthetic process
IPM43_11995	COG1960	acyl-CoA dehydrogenase activity
IPM43_12000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IPM43_12005	COG0596	Alpha beta hydrolase
IPM43_12025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPM43_12030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPM43_12035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IPM43_12040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPM43_12050	COG1079	Belongs to the binding-protein-dependent transport system permease family
IPM43_12060	COG3845	ABC transporter
IPM43_12065	COG1744	ABC transporter substrate-binding protein PnrA-like
IPM43_12080	COG1024	Enoyl-CoA hydratase
IPM43_12105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM43_12110	COG0248	Ppx GppA phosphatase
IPM43_12120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IPM43_12150	COG0427	acetyl-CoA hydrolase
IPM43_12155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPM43_12165	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_12210	COG0148	phosphopyruvate hydratase activity
IPM43_12215	COG3956	TIGRFAM MazG family protein
IPM43_12230	COG0193	aminoacyl-tRNA hydrolase activity
IPM43_12235	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPM43_12245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPM43_12260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPM43_12265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPM43_12275	COG0084	hydrolase, TatD family'
IPM43_12280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPM43_12305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPM43_12330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPM43_12335	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_12340	COG0183	Belongs to the thiolase family
IPM43_12350	COG1960	acyl-CoA dehydrogenase activity
IPM43_12380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPM43_12380	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPM43_12385	COG0012	GTP binding
IPM43_12390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IPM43_12390	COG1796	DNA polymerase
IPM43_12395	COG2860	membrane
IPM43_12400	COG1505	serine-type exopeptidase activity
IPM43_12465	COG4249	Peptidase C14 caspase catalytic subunit p20
IPM43_12465	COG2319	Wd-40 repeat
IPM43_12495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPM43_12545	COG0798	PFAM Bile acid sodium symporter
IPM43_12580	COG2226	methyltransferase
IPM43_12590	COG1672	PFAM Archaeal ATPase
IPM43_12590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IPM43_12615	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPM43_12645	COG2205	protein histidine kinase activity
IPM43_12650	COG0745	RESPONSE REGULATOR receiver
IPM43_12665	COG1477	protein flavinylation
IPM43_12700	COG1024	Enoyl-CoA hydratase
IPM43_12745	COG2130	NADP-dependent
IPM43_12750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPM43_12750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPM43_12790	COG0644	oxidoreductase
IPM43_12810	COG0137	argininosuccinate synthase activity
IPM43_12865	COG1393	Belongs to the ArsC family
IPM43_12870	COG2261	transglycosylase associated protein
IPM43_12880	COG1132	(ABC) transporter
IPM43_12890	COG0646	methionine synthase
IPM43_12890	COG1410	methionine synthase
IPM43_12900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPM43_12910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPM43_12915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IPM43_12935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IPM43_12945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM43_12945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPM43_12955	COG2171	N-acyltransferase activity
IPM43_12970	COG1714	RDD family
IPM43_12975	COG4770	biotin carboxylase activity
IPM43_12980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IPM43_12980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IPM43_12985	COG1316	TRANSCRIPTIONal
IPM43_13005	COG1091	dTDP-4-dehydrorhamnose reductase activity
IPM43_13015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPM43_13020	COG1231	oxidoreductase activity
IPM43_13050	COG0714	Associated with various cellular activities
IPM43_13060	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IPM43_13085	COG0745	RESPONSE REGULATOR receiver
IPM43_13105	COG0587	DNA-directed DNA polymerase activity
IPM43_13110	COG1280	lysine exporter protein (LysE YggA)
IPM43_13120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM43_13140	COG0705	Rhomboid family
IPM43_13140	COG0457	Tetratricopeptide repeat
IPM43_13165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM43_13180	COG1525	nuclease
IPM43_13185	COG0183	Belongs to the thiolase family
IPM43_13190	COG2816	NAD+ diphosphatase activity
IPM43_13195	COG0823	Involved in the tonB-independent uptake of proteins
IPM43_13195	COG1506	peptidase
IPM43_13195	COG4946	Tricorn protease homolog
IPM43_13275	COG1960	acyl-CoA dehydrogenase activity
IPM43_13280	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_13285	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_13290	COG1960	acyl-CoA dehydrogenase activity
IPM43_13295	COG1024	Enoyl-CoA hydratase
IPM43_13340	COG1228	amidohydrolase
IPM43_13345	COG0402	S-adenosylhomocysteine deaminase activity
IPM43_13350	COG0242	peptide deformylase activity
IPM43_13355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IPM43_13360	COG2986	histidine ammonia-lyase
IPM43_13365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IPM43_13375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_13380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IPM43_13385	COG2070	2-Nitropropane dioxygenase
IPM43_13390	COG0644	oxidoreductase
IPM43_13395	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_13400	COG2030	dehydratase
IPM43_13410	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IPM43_13460	COG0488	(ABC) transporter
IPM43_13480	COG2847	Copper chaperone PCu(A)C
IPM43_13490	COG0567	Dehydrogenase, E1 component
IPM43_13490	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPM43_13540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_13545	COG2267	carboxylic ester hydrolase activity
IPM43_13550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPM43_13555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPM43_13575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IPM43_13585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPM43_13590	COG1461	Dihydroxyacetone kinase
IPM43_13595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPM43_13605	COG0742	ribosomal rna small subunit methyltransferase
IPM43_13625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPM43_13630	COG0416	fatty acid biosynthetic process
IPM43_13640	COG0571	ribonuclease III activity
IPM43_13645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPM43_13650	COG1196	nuclear chromosome segregation
IPM43_13670	COG0228	four-way junction DNA binding
IPM43_13685	COG0336	Belongs to the RNA methyltransferase TrmD family
IPM43_13690	COG0335	large ribosomal subunit rRNA binding
IPM43_13710	COG0792	nuclease activity
IPM43_13715	COG1024	Enoyl-CoA hydratase
IPM43_13725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPM43_13735	COG2313	pseudouridylate synthase activity
IPM43_13755	COG2249	NAD(P)H dehydrogenase (quinone) activity
IPM43_13760	COG2249	NAD(P)H dehydrogenase (quinone) activity
IPM43_13780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPM43_13795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPM43_13850	COG4152	abc transporter atp-binding protein
IPM43_13890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPM43_13905	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_13910	COG2723	6-phospho-beta-galactosidase activity
IPM43_13925	COG2267	carboxylic ester hydrolase activity
IPM43_13935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPM43_13950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_13955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPM43_13975	COG2200	EAL domain
IPM43_13995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPM43_14005	COG0277	FAD linked oxidase domain protein
IPM43_14025	COG1592	Rubrerythrin
IPM43_14045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPM43_14050	COG2176	DNA-directed DNA polymerase activity
IPM43_14095	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_14100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IPM43_14145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IPM43_14150	COG1328	CTP reductase activity
IPM43_14180	COG0439	Biotin carboxylase
IPM43_14190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPM43_14195	COG2818	Glycosylase
IPM43_14210	COG2226	methyltransferase
IPM43_14225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IPM43_14250	COG0438	transferase activity, transferring glycosyl groups
IPM43_14265	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IPM43_14270	COG0298	carbon dioxide binding
IPM43_14275	COG0409	Hydrogenase expression formation protein
IPM43_14280	COG0309	Hydrogenase expression formation protein (HypE)
IPM43_14330	COG1960	acyl-CoA dehydrogenase activity
IPM43_14345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPM43_14360	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_14375	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IPM43_14385	COG2226	methyltransferase
IPM43_14390	COG1960	acyl-CoA dehydrogenase activity
IPM43_14400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_14415	COG0318	PFAM AMP-dependent synthetase and ligase
IPM43_14435	COG0745	RESPONSE REGULATOR receiver
IPM43_14455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPM43_14460	COG1381	Involved in DNA repair and RecF pathway recombination
IPM43_14465	COG0423	glycine-tRNA ligase activity
IPM43_14470	COG0134	indole-3-glycerol-phosphate synthase activity
IPM43_14475	COG0135	phosphoribosylanthranilate isomerase activity
IPM43_14480	COG0133	tryptophan synthase activity
IPM43_14485	COG0159	tryptophan synthase activity
IPM43_14500	COG2197	response regulator
IPM43_14515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPM43_14520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPM43_14525	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IPM43_14530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPM43_14535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPM43_14545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPM43_14550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPM43_14585	COG0539	negative regulation of cytoplasmic translation
IPM43_14590	COG2197	response regulator
IPM43_14600	COG0237	dephospho-CoA kinase activity
IPM43_14605	COG0556	nucleotide-excision repair
IPM43_14610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPM43_14615	COG0477	Major facilitator Superfamily
IPM43_14620	COG0322	excinuclease ABC activity
IPM43_14625	COG2226	methyltransferase
IPM43_14630	COG1660	Displays ATPase and GTPase activities
IPM43_14635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IPM43_14640	COG0126	phosphoglycerate kinase activity
IPM43_14650	COG4166	transmembrane transport
IPM43_14655	COG0601	transmembrane transport
IPM43_14660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPM43_14665	COG0444	Belongs to the ABC transporter superfamily
IPM43_14670	COG4608	Belongs to the ABC transporter superfamily
IPM43_14680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IPM43_14765	COG2329	Antibiotic biosynthesis monooxygenase
IPM43_14775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPM43_14790	COG1595	DNA-templated transcription, initiation
IPM43_14815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPM43_14825	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IPM43_14885	COG5012	cobalamin binding
IPM43_14890	COG3457	Alanine racemase
IPM43_14895	COG1525	nuclease
IPM43_14895	COG0737	Belongs to the 5'-nucleotidase family
IPM43_14895	COG4085	toxin activity
IPM43_14910	COG0022	dehydrogenase e1 component
IPM43_14930	COG0560	Phosphoserine phosphatase
IPM43_14940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPM43_14965	COG1605	Chorismate mutase
IPM43_14965	COG0287	Prephenate dehydrogenase
IPM43_15000	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IPM43_15010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IPM43_15020	COG0549	Belongs to the carbamate kinase family
IPM43_15045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPM43_15075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPM43_15090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPM43_15095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IPM43_15105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPM43_15115	COG3191	aminopeptidase activity
IPM43_15120	COG0110	maltose O-acetyltransferase activity
IPM43_15135	COG1132	(ABC) transporter
IPM43_15140	COG1132	(ABC) transporter
IPM43_15145	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_15160	COG1012	belongs to the aldehyde dehydrogenase family
IPM43_15180	COG1028	Short-chain dehydrogenase reductase Sdr
IPM43_15200	COG0697	spore germination
IPM43_15220	COG0410	ABC transporter
IPM43_15225	COG0683	leucine binding
IPM43_15230	COG1024	Enoyl-CoA hydratase
IPM43_15235	COG0484	heat shock protein binding
IPM43_15240	COG0009	L-threonylcarbamoyladenylate synthase
IPM43_15255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPM43_15255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPM43_15265	COG1362	aminopeptidase activity
IPM43_15270	COG0406	alpha-ribazole phosphatase activity
IPM43_15290	COG0746	molybdenum cofactor guanylyltransferase activity
IPM43_15295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPM43_15300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IPM43_15310	COG1192	Involved in chromosome partitioning
IPM43_15315	COG0366	Alpha amylase catalytic
IPM43_15325	COG1217	gtp-binding protein TYPA
IPM43_15340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPM43_15345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPM43_15350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPM43_15355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPM43_15360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPM43_15370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IPM43_15375	COG0006	proline dipeptidase activity
IPM43_15380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPM43_15385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM43_15395	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IPM43_15400	COG0540	Belongs to the ATCase OTCase family
IPM43_15405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPM43_15410	COG0505	Belongs to the CarA family
IPM43_15415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPM43_15420	COG0167	dihydroorotate dehydrogenase activity
IPM43_15430	COG0194	GDP metabolic process
IPM43_15445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPM43_15455	COG2813	Specifically methylates the guanine in position
IPM43_15460	COG0242	peptide deformylase activity
IPM43_15465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPM43_15470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IPM43_15470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPM43_15475	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPM43_15480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPM43_15500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPM43_15505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPM43_15510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPM43_15515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPM43_15525	COG0072	phenylalanine-tRNA ligase activity
IPM43_15530	COG1678	Uncharacterized ACR, COG1678
IPM43_15535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IPM43_15540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IPM43_15545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPM43_15550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IPM43_15555	COG1438	arginine binding
IPM43_15560	COG0165	Argininosuccinate lyase
IPM43_15565	COG2095	MarC family integral membrane protein
IPM43_15575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPM43_15605	COG1830	Aldolase
IPM43_15610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPM43_15610	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPM43_15615	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPM43_15625	COG0647	UMP catabolic process
IPM43_15635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPM43_15640	COG0497	DNA recombination
IPM43_15645	COG0504	CTP synthase activity
IPM43_15665	COG0180	Tryptophanyl-tRNA synthetase
IPM43_15675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPM43_15685	COG0287	Prephenate dehydrogenase
IPM43_15690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IPM43_15700	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPM43_15710	COG0277	FAD linked oxidase domain protein
IPM43_15715	COG0300	oxidoreductase activity
IPM43_15740	COG1216	Glycosyl transferase, family 2
IPM43_15760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPM43_15760	COG2755	lipolytic protein G-D-S-L family
IPM43_15785	COG4608	Belongs to the ABC transporter superfamily
IPM43_15790	COG0444	Belongs to the ABC transporter superfamily
IPM43_15795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPM43_15800	COG0601	transmembrane transport
IPM43_15810	COG2326	polyphosphate kinase activity
IPM43_15840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IPM43_15850	COG2154	pterin-4-alpha-carbinolamine dehydratase
IPM43_15870	COG0277	FAD linked oxidase domain protein
IPM43_15875	COG0584	glycerophosphoryl diester phosphodiesterase
IPM43_15880	COG1012	belongs to the aldehyde dehydrogenase family