locus-tag	class	description
Actkin_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Actkin_00003	COG0592	DNA-directed DNA polymerase activity
Actkin_00004	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Actkin_00005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Actkin_00006	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
Actkin_00007	COG0187	DNA topoisomerase II activity
Actkin_00009	COG3266	domain, Protein
Actkin_00028	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Actkin_00029	COG0705	Rhomboid family
Actkin_00029	COG0457	Tetratricopeptide repeat
Actkin_00032	COG3764	Sortase (surface protein transpeptidase)
Actkin_00036	COG0515	serine threonine protein kinase
Actkin_00036	COG2815	serine threonine protein kinase
Actkin_00037	COG0515	serine threonine protein kinase
Actkin_00038	COG0768	penicillin binding
Actkin_00041	COG1716	ATPase activity
Actkin_00042	COG1716	ATPase activity
Actkin_00045	COG0702	epimerase
Actkin_00048	COG1309	transcriptional regulator
Actkin_00067	COG0667	Aldo Keto reductase
Actkin_00068	COG0405	Gamma-glutamyltransferase
Actkin_00070	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_00071	COG0477	Major facilitator Superfamily
Actkin_00073	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_00078	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Actkin_00079	COG0515	serine threonine protein kinase
Actkin_00085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Actkin_00086	COG3275	phosphorelay sensor kinase activity
Actkin_00090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_00092	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_00093	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Actkin_00093	COG0425	Belongs to the sulfur carrier protein TusA family
Actkin_00099	COG0653	protein targeting
Actkin_00101	COG1528	Iron-storage protein
Actkin_00117	COG1271	oxidase subunit
Actkin_00118	COG1294	oxidase, subunit
Actkin_00119	COG4988	ABC transporter
Actkin_00123	COG1072	(Pantothenic acid kinase))
Actkin_00124	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Actkin_00126	COG0406	alpha-ribazole phosphatase activity
Actkin_00129	COG0477	Major facilitator Superfamily
Actkin_00131	COG2197	response regulator
Actkin_00141	COG1690	Belongs to the RtcB family
Actkin_00145	COG0754	glutathionylspermidine amidase activity
Actkin_00146	COG3766	membrane
Actkin_00147	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Actkin_00148	COG0579	oxidoreductase
Actkin_00153	COG1216	Glycosyl transferase, family 2
Actkin_00154	COG1216	Glycosyl transferase, family 2
Actkin_00156	COG0561	phosphatase activity
Actkin_00159	COG0671	phosphoesterase, PA-phosphatase related
Actkin_00160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Actkin_00163	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_00164	COG0277	FAD linked oxidase domain protein
Actkin_00167	COG1216	Glycosyl transferase, family 2
Actkin_00172	COG2089	acid synthase
Actkin_00173	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Actkin_00174	COG1086	Polysaccharide biosynthesis protein
Actkin_00175	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Actkin_00180	COG2234	aminopeptidase activity
Actkin_00181	COG2234	aminopeptidase activity
Actkin_00183	COG0697	spore germination
Actkin_00184	COG1846	Transcriptional regulator
Actkin_00190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Actkin_00192	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Actkin_00196	COG0252	asparaginase activity
Actkin_00197	COG0596	Alpha beta hydrolase
Actkin_00199	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_00202	COG2814	Major facilitator Superfamily
Actkin_00203	COG3559	Exporter of polyketide antibiotics
Actkin_00205	COG1131	(ABC) transporter
Actkin_00214	COG0287	Prephenate dehydrogenase
Actkin_00215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_00218	COG1278	Cold shock
Actkin_00221	COG0860	N-Acetylmuramoyl-L-alanine amidase
Actkin_00221	COG2247	cell wall binding repeat
Actkin_00225	COG0006	proline dipeptidase activity
Actkin_00231	COG1473	amidohydrolase
Actkin_00234	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Actkin_00235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Actkin_00237	COG0747	negative chemotaxis
Actkin_00238	COG0601	transmembrane transport
Actkin_00239	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_00241	COG4608	Belongs to the ABC transporter superfamily
Actkin_00250	COG0657	acetylesterase activity
Actkin_00257	COG1408	metallophosphoesterase
Actkin_00258	COG1610	YqeY-like protein
Actkin_00259	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Actkin_00270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_00271	COG0592	DNA-directed DNA polymerase activity
Actkin_00281	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Actkin_00284	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_00285	COG3706	GGDEF domain
Actkin_00288	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Actkin_00289	COG1737	Transcriptional regulator
Actkin_00290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Actkin_00291	COG3876	Protein conserved in bacteria
Actkin_00292	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_00302	COG0346	lactoylglutathione lyase activity
Actkin_00303	COG1205	dead DEAH box helicase
Actkin_00303	COG1111	helicase
Actkin_00304	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Actkin_00307	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Actkin_00307	COG1754	DNA topoisomerase type I activity
Actkin_00308	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Actkin_00309	COG0470	DNA polymerase III
Actkin_00314	COG0583	DNA-binding transcription factor activity
Actkin_00315	COG0515	serine threonine protein kinase
Actkin_00315	COG2815	serine threonine protein kinase
Actkin_00321	COG0583	DNA-binding transcription factor activity
Actkin_00326	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Actkin_00327	COG2027	D-alanyl-D-alanine carboxypeptidase
Actkin_00329	COG0037	tRNA processing
Actkin_00335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Actkin_00336	COG0302	gtp cyclohydrolase
Actkin_00338	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Actkin_00344	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Actkin_00345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Actkin_00346	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Actkin_00356	COG1515	deoxyribonuclease V activity
Actkin_00357	COG3903	Transcriptional regulator
Actkin_00357	COG3629	intracellular signal transduction
Actkin_00363	COG1194	a g-specific adenine glycosylase
Actkin_00366	COG1609	Transcriptional regulator
Actkin_00368	COG3842	ATPase activity
Actkin_00369	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Actkin_00372	COG0842	Transport permease protein
Actkin_00373	COG1511	domain protein
Actkin_00373	COG0842	Transport permease protein
Actkin_00374	COG1131	(ABC) transporter
Actkin_00380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Actkin_00381	COG0596	Alpha beta hydrolase
Actkin_00384	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_00385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Actkin_00386	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Actkin_00387	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_00388	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_00389	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_00390	COG3903	Transcriptional regulator
Actkin_00390	COG3629	intracellular signal transduction
Actkin_00391	COG1819	glycosyl
Actkin_00394	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Actkin_00399	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_00400	COG0215	cysteine-tRNA ligase activity
Actkin_00402	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Actkin_00403	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Actkin_00404	COG1329	Transcriptional regulator
Actkin_00405	COG2847	Copper chaperone PCu(A)C
Actkin_00406	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Actkin_00408	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Actkin_00425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_00427	COG4399	Belongs to the UPF0754 family
Actkin_00428	COG0456	acetyltransferase
Actkin_00429	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Actkin_00430	COG1917	Cupin 2, conserved barrel domain protein
Actkin_00431	COG5285	phytanoyl-CoA dioxygenase
Actkin_00432	COG3903	Transcriptional regulator
Actkin_00432	COG3629	intracellular signal transduction
Actkin_00435	COG2971	BadF BadG BcrA BcrD
Actkin_00437	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Actkin_00438	COG2188	Transcriptional regulator
Actkin_00440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Actkin_00441	COG0352	thiamine-phosphate diphosphorylase activity
Actkin_00442	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_00442	COG2022	thiamine diphosphate biosynthetic process
Actkin_00444	COG2022	thiamine diphosphate biosynthetic process
Actkin_00449	COG0351	phosphomethylpyrimidine kinase
Actkin_00450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Actkin_00452	COG1280	lysine exporter protein (LysE YggA)
Actkin_00456	COG0242	peptide deformylase activity
Actkin_00457	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Actkin_00459	COG0688	phosphatidylethanolamine metabolic process
Actkin_00463	COG0459	protein refolding
Actkin_00465	COG1061	Type III restriction enzyme res subunit
Actkin_00468	COG1116	anion transmembrane transporter activity
Actkin_00469	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Actkin_00470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Actkin_00473	COG2018	Roadblock/LC7 domain
Actkin_00480	COG0315	cyclic pyranopterin monophosphate synthase activity
Actkin_00482	COG1388	LysM domain
Actkin_00491	COG3304	Inner membrane component domain
Actkin_00492	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_00493	COG0546	phosphoglycolate phosphatase activity
Actkin_00495	COG1278	Cold shock
Actkin_00497	COG2814	Major facilitator Superfamily
Actkin_00503	COG2252	PERMEase
Actkin_00505	COG2814	Major facilitator Superfamily
Actkin_00508	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_00510	COG1132	(ABC) transporter
Actkin_00511	COG1132	(ABC) transporter
Actkin_00513	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_00513	COG2207	Transcriptional regulator
Actkin_00519	COG0259	pyridoxamine-phosphate oxidase activity
Actkin_00520	COG2814	Major facilitator Superfamily
Actkin_00521	COG0640	Transcriptional regulator
Actkin_00523	COG2017	converts alpha-aldose to the beta-anomer
Actkin_00524	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Actkin_00526	COG1960	acyl-CoA dehydrogenase activity
Actkin_00529	COG0415	Belongs to the DNA photolyase family
Actkin_00531	COG1668	transmembrane transport
Actkin_00537	COG0277	FAD linked oxidase domain protein
Actkin_00539	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_00543	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_00546	COG1169	isochorismate synthase
Actkin_00548	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_00549	COG2197	response regulator
Actkin_00550	COG0477	Major facilitator Superfamily
Actkin_00551	COG1022	Amp-dependent synthetase and ligase
Actkin_00565	COG1695	Transcriptional regulator
Actkin_00566	COG1902	pentaerythritol trinitrate reductase activity
Actkin_00566	COG0446	pyridine nucleotide-disulphide oxidoreductase
Actkin_00574	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Actkin_00575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Actkin_00576	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Actkin_00577	COG3706	GGDEF domain
Actkin_00578	COG2197	response regulator
Actkin_00580	COG1668	transmembrane transport
Actkin_00581	COG4152	abc transporter atp-binding protein
Actkin_00587	COG3903	Transcriptional regulator
Actkin_00587	COG3629	intracellular signal transduction
Actkin_00596	COG0018	arginyl-trna synthetase
Actkin_00597	COG0124	histidyl-tRNA synthetase
Actkin_00598	COG0588	phosphoglycerate mutase activity
Actkin_00599	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_00601	COG0745	RESPONSE REGULATOR receiver
Actkin_00602	COG2205	protein histidine kinase activity
Actkin_00603	COG1349	DNA-binding transcription factor activity
Actkin_00605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Actkin_00607	COG0745	RESPONSE REGULATOR receiver
Actkin_00608	COG5002	protein histidine kinase activity
Actkin_00609	COG0521	Mo-molybdopterin cofactor biosynthetic process
Actkin_00609	COG0315	cyclic pyranopterin monophosphate synthase activity
Actkin_00611	COG1970	mechanosensitive ion channel activity
Actkin_00614	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Actkin_00615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Actkin_00617	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Actkin_00629	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Actkin_00631	COG0515	serine threonine protein kinase
Actkin_00633	COG4977	sequence-specific DNA binding
Actkin_00641	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_00642	COG0084	hydrolase, TatD family'
Actkin_00644	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Actkin_00645	COG0193	aminoacyl-tRNA hydrolase activity
Actkin_00646	COG3599	regulation of cell shape
Actkin_00647	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_00648	COG0488	(ABC) transporter
Actkin_00652	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Actkin_00653	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Actkin_00654	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Actkin_00659	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Actkin_00667	COG2133	pyrroloquinoline quinone binding
Actkin_00668	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_00673	COG3956	TIGRFAM MazG family protein
Actkin_00676	COG4106	trans-aconitate 2-methyltransferase activity
Actkin_00679	COG0148	phosphopyruvate hydratase activity
Actkin_00691	COG0714	Associated with various cellular activities
Actkin_00701	COG2267	carboxylic ester hydrolase activity
Actkin_00704	COG0183	Belongs to the thiolase family
Actkin_00705	COG2755	lipolytic protein G-D-S-L family
Actkin_00717	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Actkin_00719	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Actkin_00721	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_00723	COG3541	Predicted nucleotidyltransferase
Actkin_00726	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Actkin_00728	COG1331	Highly conserved protein containing a thioredoxin domain
Actkin_00730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Actkin_00733	COG1832	CoA-binding protein
Actkin_00735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Actkin_00739	COG0419	ATPase involved in DNA repair
Actkin_00740	COG0420	3'-5' exonuclease activity
Actkin_00743	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Actkin_00745	COG1570	exodeoxyribonuclease VII activity
Actkin_00747	COG1722	exodeoxyribonuclease VII activity
Actkin_00752	COG0492	ferredoxin-NADP+ reductase activity
Actkin_00753	COG0114	fumarate hydratase activity
Actkin_00755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_00757	COG1793	dna ligase
Actkin_00759	COG1404	Belongs to the peptidase S8 family
Actkin_00760	COG0012	GTP binding
Actkin_00762	COG3654	unkown
Actkin_00766	COG1840	ABC-type Fe3 transport system, periplasmic component
Actkin_00767	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Actkin_00768	COG3842	ATPase activity
Actkin_00773	COG1131	(ABC) transporter
Actkin_00775	COG0745	RESPONSE REGULATOR receiver
Actkin_00776	COG0642	Histidine kinase
Actkin_00778	COG0180	Tryptophanyl-tRNA synthetase
Actkin_00780	COG1217	gtp-binding protein TYPA
Actkin_00784	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_00786	COG4608	Belongs to the ABC transporter superfamily
Actkin_00787	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_00790	COG0456	acetyltransferase
Actkin_00799	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_00801	COG1611	Belongs to the LOG family
Actkin_00802	COG1611	Belongs to the LOG family
Actkin_00804	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Actkin_00805	COG0463	Glycosyl transferase, family 2
Actkin_00806	COG1132	(ABC) transporter
Actkin_00807	COG4988	ABC transporter
Actkin_00808	COG1294	oxidase, subunit
Actkin_00809	COG1271	oxidase subunit
Actkin_00814	COG2818	Glycosylase
Actkin_00815	COG1024	Enoyl-CoA hydratase
Actkin_00818	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Actkin_00820	COG0297	glycogen (starch) synthase activity
Actkin_00821	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Actkin_00822	COG4122	O-methyltransferase activity
Actkin_00823	COG1595	DNA-templated transcription, initiation
Actkin_00825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Actkin_00826	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Actkin_00830	COG2239	Acts as a magnesium transporter
Actkin_00833	COG2301	Belongs to the HpcH HpaI aldolase family
Actkin_00834	COG2301	Belongs to the HpcH HpaI aldolase family
Actkin_00835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_00835	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_00835	COG3321	synthase
Actkin_00835	COG4221	oxidoreductase activity
Actkin_00844	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_00847	COG1595	DNA-templated transcription, initiation
Actkin_00867	COG0598	Magnesium transport protein CorA
Actkin_00874	COG2095	MarC family integral membrane protein
Actkin_00880	COG0513	Belongs to the DEAD box helicase family
Actkin_00891	COG1309	transcriptional regulator
Actkin_00896	COG0243	molybdopterin cofactor binding
Actkin_00897	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Actkin_00898	COG2223	nitrite transmembrane transporter activity
Actkin_00900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Actkin_00900	COG2146	nitrite reductase [NAD(P)H] activity
Actkin_00907	COG3695	enzyme binding
Actkin_00911	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Actkin_00917	COG0612	Peptidase, M16
Actkin_00925	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Actkin_00931	COG1309	transcriptional regulator
Actkin_00933	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Actkin_00945	COG0557	exoribonuclease II activity
Actkin_00949	COG0435	Glutathione S-transferase
Actkin_00950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Actkin_00951	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Actkin_00951	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Actkin_00952	COG0653	protein targeting
Actkin_00954	COG0477	Major facilitator Superfamily
Actkin_00958	COG0174	glutamine synthetase
Actkin_00959	COG0154	amidase activity
Actkin_00966	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Actkin_00979	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Actkin_00983	COG3480	Lon protease (S16) C-terminal proteolytic domain
Actkin_00985	COG1615	UPF0182 protein
Actkin_00995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Actkin_00996	COG2884	Cell division ATP-binding protein ftsE
Actkin_00997	COG2177	Part of the ABC transporter FtsEX involved in
Actkin_00998	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Actkin_01000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Actkin_01003	COG4585	Histidine kinase
Actkin_01008	COG0737	Belongs to the 5'-nucleotidase family
Actkin_01010	COG4585	Histidine kinase
Actkin_01011	COG2197	response regulator
Actkin_01016	COG0667	Aldo Keto reductase
Actkin_01018	COG2226	methyltransferase
Actkin_01029	COG0657	acetylesterase activity
Actkin_01059	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Actkin_01061	COG1643	Atp-dependent helicase
Actkin_01068	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Actkin_01073	COG1476	TRANSCRIPTIONal
Actkin_01075	COG1131	(ABC) transporter
Actkin_01082	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Actkin_01084	COG1404	Belongs to the peptidase S8 family
Actkin_01086	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Actkin_01091	COG2072	flavoprotein involved in K transport
Actkin_01095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Actkin_01096	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_01097	COG1104	cysteine desulfurase activity
Actkin_01099	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Actkin_01100	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_01103	COG3764	Sortase (surface protein transpeptidase)
Actkin_01105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_01107	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Actkin_01108	COG0800	Aldolase
Actkin_01115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Actkin_01116	COG0191	fructose-bisphosphate aldolase activity
Actkin_01123	COG1278	Cold shock
Actkin_01128	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Actkin_01129	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Actkin_01135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Actkin_01136	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Actkin_01142	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Actkin_01145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Actkin_01146	COG1335	isochorismatase
Actkin_01147	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Actkin_01148	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Actkin_01158	COG0667	Aldo Keto reductase
Actkin_01161	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Actkin_01163	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Actkin_01165	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Actkin_01166	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Actkin_01180	COG1309	transcriptional regulator
Actkin_01191	COG2226	methyltransferase
Actkin_01192	COG3629	intracellular signal transduction
Actkin_01192	COG3903	Transcriptional regulator
Actkin_01194	COG1316	TRANSCRIPTIONal
Actkin_01195	COG2234	aminopeptidase activity
Actkin_01195	COG4935	Belongs to the peptidase S8 family
Actkin_01199	COG3903	Transcriptional regulator
Actkin_01199	COG3629	intracellular signal transduction
Actkin_01200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_01201	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Actkin_01202	COG1834	amidinotransferase
Actkin_01204	COG0475	glutathione-regulated potassium exporter activity
Actkin_01208	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Actkin_01210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_01215	COG4865	methylaspartate mutase activity
Actkin_01216	COG0017	Asparaginyl-tRNA synthetase
Actkin_01231	COG1376	ErfK ybiS ycfS ynhG family protein
Actkin_01234	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Actkin_01235	COG0433	COG0433 Predicted ATPase
Actkin_01242	COG2814	Major facilitator Superfamily
Actkin_01249	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_01250	COG1309	transcriptional regulator
Actkin_01251	COG1960	acyl-CoA dehydrogenase activity
Actkin_01266	COG3795	YCII-related domain
Actkin_01267	COG4941	Belongs to the sigma-70 factor family
Actkin_01269	COG4941	Belongs to the sigma-70 factor family
Actkin_01271	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_01272	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Actkin_01275	COG2132	Multicopper oxidase
Actkin_01279	COG0646	methionine synthase
Actkin_01279	COG1410	methionine synthase
Actkin_01286	COG1653	transport
Actkin_01289	COG3629	intracellular signal transduction
Actkin_01289	COG3903	Transcriptional regulator
Actkin_01290	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Actkin_01303	COG1609	Transcriptional regulator
Actkin_01304	COG2223	nitrite transmembrane transporter activity
Actkin_01310	COG2902	Dehydrogenase
Actkin_01313	COG0366	Alpha amylase catalytic
Actkin_01315	COG0668	transmembrane transport
Actkin_01319	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Actkin_01321	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Actkin_01328	COG4552	Acetyltransferase involved in intracellular survival and related
Actkin_01335	COG0544	peptidyl-prolyl cis-trans isomerase activity
Actkin_01336	COG0740	serine-type endopeptidase activity
Actkin_01337	COG0740	serine-type endopeptidase activity
Actkin_01341	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Actkin_01342	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Actkin_01345	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_01353	COG0525	valine-tRNA ligase activity
Actkin_01354	COG0525	valine-tRNA ligase activity
Actkin_01357	COG0477	Major facilitator Superfamily
Actkin_01360	COG2175	clavaminate synthase activity
Actkin_01361	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_01361	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_01363	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Actkin_01364	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Actkin_01366	COG0285	dihydrofolate synthase activity
Actkin_01372	COG0105	UTP biosynthetic process
Actkin_01373	COG1131	(ABC) transporter
Actkin_01381	COG1530	ribonuclease E activity
Actkin_01381	COG1530	ribonuclease E activity
Actkin_01382	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Actkin_01383	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Actkin_01384	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Actkin_01388	COG0514	ATP-dependent DNA helicase (RecQ)
Actkin_01389	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Actkin_01389	COG0778	Nitroreductase
Actkin_01390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Actkin_01391	COG0799	negative regulation of ribosome biogenesis
Actkin_01393	COG2755	lipolytic protein G-D-S-L family
Actkin_01394	COG1307	EDD domain protein, DegV family
Actkin_01396	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_01403	COG0268	Binds directly to 16S ribosomal RNA
Actkin_01413	COG2070	2-Nitropropane dioxygenase
Actkin_01415	COG0604	alcohol dehydrogenase
Actkin_01418	COG2732	(Barnase) inhibitor
Actkin_01421	COG2267	carboxylic ester hydrolase activity
Actkin_01425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Actkin_01434	COG1309	transcriptional regulator
Actkin_01435	COG2124	cytochrome p450
Actkin_01439	COG1420	regulation of RNA biosynthetic process
Actkin_01440	COG0484	heat shock protein binding
Actkin_01442	COG0537	adenosine 5'-monophosphoramidase activity
Actkin_01444	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Actkin_01448	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Actkin_01451	COG1381	Involved in DNA repair and RecF pathway recombination
Actkin_01452	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Actkin_01454	COG0701	Predicted permease
Actkin_01460	COG0423	glycine-tRNA ligase activity
Actkin_01466	COG1595	DNA-templated transcription, initiation
Actkin_01469	COG4106	trans-aconitate 2-methyltransferase activity
Actkin_01477	COG1733	regulation of RNA biosynthetic process
Actkin_01483	COG0477	Major facilitator Superfamily
Actkin_01490	COG0714	Associated with various cellular activities
Actkin_01506	COG0028	Belongs to the TPP enzyme family
Actkin_01511	COG1309	transcriptional regulator
Actkin_01512	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Actkin_01513	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Actkin_01521	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_01522	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Actkin_01525	COG0668	transmembrane transport
Actkin_01526	COG3201	nicotinamide mononucleotide transporter
Actkin_01527	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Actkin_01533	COG0586	Pfam SNARE associated Golgi protein
Actkin_01534	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Actkin_01539	COG0321	lipoyl(octanoyl) transferase activity
Actkin_01542	COG0508	dehydrogenase complex catalyzes the overall conversion of
Actkin_01543	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Actkin_01545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Actkin_01547	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Actkin_01548	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Actkin_01554	COG0667	Aldo Keto reductase
Actkin_01556	COG1929	Belongs to the glycerate kinase type-1 family
Actkin_01559	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_01564	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Actkin_01566	COG0436	Aminotransferase
Actkin_01568	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Actkin_01570	COG1845	cytochrome c oxidase, subunit III
Actkin_01571	COG2010	Cytochrome c
Actkin_01573	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Actkin_01579	COG1876	peptidase activity
Actkin_01583	COG0438	transferase activity, transferring glycosyl groups
Actkin_01588	COG0003	Pfam Anion-transporting ATPase
Actkin_01590	COG1940	carbohydrate kinase activity
Actkin_01599	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Actkin_01601	COG2815	serine threonine protein kinase
Actkin_01601	COG0515	serine threonine protein kinase
Actkin_01606	COG0142	geranyltranstransferase activity
Actkin_01616	COG1201	RNA secondary structure unwinding
Actkin_01617	COG0443	Heat shock 70 kDa protein
Actkin_01620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Actkin_01621	COG2137	regulation of response to DNA damage stimulus
Actkin_01624	COG1053	succinate dehydrogenase
Actkin_01626	COG0765	amino acid transport
Actkin_01627	COG0765	amino acid transport
Actkin_01629	COG1126	abc transporter atp-binding protein
Actkin_01630	COG0745	RESPONSE REGULATOR receiver
Actkin_01633	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Actkin_01635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Actkin_01636	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Actkin_01638	COG1196	nuclear chromosome segregation
Actkin_01641	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Actkin_01643	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Actkin_01645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Actkin_01646	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Actkin_01647	COG2321	neutral zinc metallopeptidase
Actkin_01649	COG4279	zinc finger
Actkin_01650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Actkin_01651	COG1505	serine-type exopeptidase activity
Actkin_01655	COG2936	dipeptidyl-peptidase activity
Actkin_01656	COG0741	lytic transglycosylase activity
Actkin_01656	COG0739	heme binding
Actkin_01656	COG1196	nuclear chromosome segregation
Actkin_01659	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Actkin_01660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Actkin_01664	COG0123	including yeast histone deacetylase and acetoin utilization protein
Actkin_01673	COG1490	D-aminoacyl-tRNA deacylase activity
Actkin_01674	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Actkin_01676	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_01679	COG4555	ABC transporter
Actkin_01680	COG2313	pseudouridylate synthase activity
Actkin_01684	COG4213	ABC transporter substrate-binding protein
Actkin_01686	COG4214	carbohydrate transport
Actkin_01692	COG0483	inositol monophosphate 1-phosphatase activity
Actkin_01696	COG0756	dUTP diphosphatase activity
Actkin_01698	COG1280	lysine exporter protein (LysE YggA)
Actkin_01704	COG0569	domain protein
Actkin_01705	COG0531	amino acid
Actkin_01706	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Actkin_01708	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Actkin_01712	COG0235	Class ii aldolase
Actkin_01713	COG0745	RESPONSE REGULATOR receiver
Actkin_01714	COG2205	protein histidine kinase activity
Actkin_01716	COG1024	Enoyl-CoA hydratase
Actkin_01716	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_01717	COG0183	Belongs to the thiolase family
Actkin_01721	COG0673	inositol 2-dehydrogenase activity
Actkin_01726	COG0693	protein deglycase activity
Actkin_01728	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Actkin_01730	COG3253	May function as heme-dependent peroxidase
Actkin_01733	COG3220	belongs to the UPF0276 family
Actkin_01743	COG1793	dna ligase
Actkin_01750	COG1302	Protein conserved in bacteria
Actkin_01759	COG0640	Transcriptional regulator
Actkin_01764	COG1132	(ABC) transporter
Actkin_01765	COG1132	(ABC) transporter
Actkin_01766	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_01770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Actkin_01774	COG4991	sh3 domain protein
Actkin_01775	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_01776	COG0488	(ABC) transporter
Actkin_01778	COG1132	(ABC) transporter
Actkin_01781	COG4821	SIS domain
Actkin_01782	COG0596	Alpha beta hydrolase
Actkin_01783	COG0596	Alpha beta hydrolase
Actkin_01786	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Actkin_01787	COG1316	TRANSCRIPTIONal
Actkin_01790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Actkin_01792	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_01793	COG2326	polyphosphate kinase activity
Actkin_01794	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Actkin_01804	COG1960	acyl-CoA dehydrogenase activity
Actkin_01805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_01811	COG1309	transcriptional regulator
Actkin_01812	COG0183	Belongs to the thiolase family
Actkin_01813	COG1024	Enoyl-CoA hydratase
Actkin_01813	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_01817	COG2351	hydroxyisourate hydrolase activity
Actkin_01823	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Actkin_01826	COG3835	regulator
Actkin_01828	COG1120	ATPase activity
Actkin_01829	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_01831	COG0477	Major facilitator Superfamily
Actkin_01832	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_01833	COG3433	isochorismatase activity
Actkin_01833	COG1535	isochorismatase
Actkin_01843	COG0515	serine threonine protein kinase
Actkin_01845	COG1132	(ABC) transporter
Actkin_01847	COG1132	(ABC) transporter
Actkin_01850	COG0395	ABC-type sugar transport system, permease component
Actkin_01853	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_01857	COG1404	Belongs to the peptidase S8 family
Actkin_01861	COG0601	transmembrane transport
Actkin_01862	COG0444	Belongs to the ABC transporter superfamily
Actkin_01863	COG4608	Belongs to the ABC transporter superfamily
Actkin_01868	COG0667	Aldo Keto reductase
Actkin_01872	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Actkin_01880	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_01884	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_01886	COG0586	Pfam SNARE associated Golgi protein
Actkin_01890	COG1132	(ABC) transporter
Actkin_01898	COG1846	Transcriptional regulator
Actkin_01898	COG1940	carbohydrate kinase activity
Actkin_01900	COG1175	transmembrane transport
Actkin_01901	COG0395	ABC-type sugar transport system, permease component
Actkin_01902	COG1486	melibiose metabolic process
Actkin_01909	COG4941	Belongs to the sigma-70 factor family
Actkin_01913	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_01919	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Actkin_01922	COG3568	Endonuclease Exonuclease Phosphatase
Actkin_01925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_01928	COG0477	Major facilitator Superfamily
Actkin_01940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Actkin_01941	COG1115	amino acid carrier protein
Actkin_01942	COG0697	spore germination
Actkin_01949	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Actkin_01950	COG1120	ATPase activity
Actkin_01951	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_01952	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_01953	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_01956	COG1560	Kdo2-lipid A biosynthetic process
Actkin_01957	COG0438	transferase activity, transferring glycosyl groups
Actkin_01961	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Actkin_01965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Actkin_01966	COG0217	transcriptional regulatory protein
Actkin_01970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Actkin_01971	COG0632	four-way junction helicase activity
Actkin_01972	COG2255	four-way junction helicase activity
Actkin_01973	COG1862	Preprotein translocase
Actkin_01975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Actkin_01976	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Actkin_01977	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Actkin_01982	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Actkin_01984	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Actkin_01996	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Actkin_01999	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Actkin_02006	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Actkin_02009	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Actkin_02011	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Actkin_02012	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Actkin_02013	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Actkin_02014	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Actkin_02017	COG0006	proline dipeptidase activity
Actkin_02018	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Actkin_02019	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Actkin_02022	COG0540	Belongs to the ATCase OTCase family
Actkin_02025	COG0505	Belongs to the CarA family
Actkin_02027	COG0284	orotidine-5'-phosphate decarboxylase activity
Actkin_02029	COG0194	GDP metabolic process
Actkin_02030	COG1758	RNA polymerase activity
Actkin_02032	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Actkin_02035	COG0242	peptide deformylase activity
Actkin_02036	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Actkin_02039	COG0252	asparaginase activity
Actkin_02042	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Actkin_02043	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Actkin_02044	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Actkin_02045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_02046	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Actkin_02048	COG0137	argininosuccinate synthase activity
Actkin_02049	COG0165	Argininosuccinate lyase
Actkin_02050	COG2094	Belongs to the DNA glycosylase MPG family
Actkin_02051	COG3903	Transcriptional regulator
Actkin_02051	COG3629	intracellular signal transduction
Actkin_02052	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Actkin_02057	COG0647	UMP catabolic process
Actkin_02060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Actkin_02065	COG0504	CTP synthase activity
Actkin_02066	COG0494	nUDIX hydrolase
Actkin_02070	COG0640	Transcriptional regulator
Actkin_02074	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Actkin_02077	COG0475	glutathione-regulated potassium exporter activity
Actkin_02080	COG1960	acyl-CoA dehydrogenase activity
Actkin_02082	COG1024	Enoyl-CoA hydratase
Actkin_02083	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_02087	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_02092	COG0640	Transcriptional regulator
Actkin_02095	COG1160	GTP binding
Actkin_02097	COG2197	response regulator
Actkin_02098	COG4585	Histidine kinase
Actkin_02100	COG4974	Belongs to the 'phage' integrase family
Actkin_02118	COG0438	transferase activity, transferring glycosyl groups
Actkin_02118	COG1216	Glycosyl transferase, family 2
Actkin_02128	COG1518	maintenance of DNA repeat elements
Actkin_02172	COG3629	intracellular signal transduction
Actkin_02172	COG3903	Transcriptional regulator
Actkin_02173	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Actkin_02189	COG0583	DNA-binding transcription factor activity
Actkin_02201	COG2318	DinB family
Actkin_02204	COG0596	Alpha beta hydrolase
Actkin_02213	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Actkin_02215	COG1764	response to oxidative stress
Actkin_02217	COG0142	geranyltranstransferase activity
Actkin_02221	COG0644	oxidoreductase
Actkin_02228	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Actkin_02238	COG0517	IMP dehydrogenase activity
Actkin_02238	COG0617	tRNA 3'-terminal CCA addition
Actkin_02238	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Actkin_02244	COG0515	serine threonine protein kinase
Actkin_02247	COG1653	transport
Actkin_02258	COG2197	response regulator
Actkin_02262	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Actkin_02267	COG3903	Transcriptional regulator
Actkin_02267	COG3629	intracellular signal transduction
Actkin_02270	COG0640	Transcriptional regulator
Actkin_02272	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_02277	COG0477	Major facilitator Superfamily
Actkin_02281	COG2211	Major facilitator Superfamily
Actkin_02287	COG0539	negative regulation of cytoplasmic translation
Actkin_02288	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Actkin_02298	COG4585	Histidine kinase
Actkin_02299	COG2197	response regulator
Actkin_02302	COG0531	amino acid
Actkin_02308	COG1672	PFAM Archaeal ATPase
Actkin_02308	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_02314	COG0574	Belongs to the PEP-utilizing enzyme family
Actkin_02314	COG3848	Pyruvate phosphate dikinase
Actkin_02319	COG0745	RESPONSE REGULATOR receiver
Actkin_02320	COG2205	protein histidine kinase activity
Actkin_02321	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Actkin_02322	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Actkin_02323	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_02334	COG3290	protein histidine kinase activity
Actkin_02339	COG3629	intracellular signal transduction
Actkin_02339	COG3903	Transcriptional regulator
Actkin_02342	COG1309	transcriptional regulator
Actkin_02344	COG1960	acyl-CoA dehydrogenase activity
Actkin_02345	COG1960	acyl-CoA dehydrogenase activity
Actkin_02351	COG0183	Belongs to the thiolase family
Actkin_02353	COG1024	Enoyl-CoA hydratase
Actkin_02354	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_02358	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_02366	COG2076	Multidrug Resistance protein
Actkin_02368	COG3795	YCII-related domain
Actkin_02369	COG4941	Belongs to the sigma-70 factor family
Actkin_02370	COG3153	acetyltransferase
Actkin_02373	COG2267	carboxylic ester hydrolase activity
Actkin_02375	COG3708	Transcriptional regulator
Actkin_02375	COG2207	Transcriptional regulator
Actkin_02381	COG3938	Belongs to the proline racemase family
Actkin_02382	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_02384	COG2124	cytochrome p450
Actkin_02386	COG5001	Diguanylate cyclase
Actkin_02389	COG0513	Belongs to the DEAD box helicase family
Actkin_02391	COG0740	serine-type endopeptidase activity
Actkin_02392	COG0740	serine-type endopeptidase activity
Actkin_02395	COG0326	Molecular chaperone. Has ATPase activity
Actkin_02397	COG1131	(ABC) transporter
Actkin_02400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Actkin_02410	COG2124	cytochrome p450
Actkin_02413	COG2813	Specifically methylates the guanine in position
Actkin_02418	COG2124	cytochrome p450
Actkin_02419	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_02423	COG2124	cytochrome p450
Actkin_02435	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_02436	COG0463	Glycosyl transferase, family 2
Actkin_02445	COG3903	Transcriptional regulator
Actkin_02445	COG3629	intracellular signal transduction
Actkin_02454	COG3629	intracellular signal transduction
Actkin_02454	COG3903	Transcriptional regulator
Actkin_02455	COG1595	DNA-templated transcription, initiation
Actkin_02458	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Actkin_02459	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Actkin_02461	COG0402	S-adenosylhomocysteine deaminase activity
Actkin_02465	COG2197	response regulator
Actkin_02470	COG3629	intracellular signal transduction
Actkin_02471	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Actkin_02476	COG3629	intracellular signal transduction
Actkin_02476	COG3903	Transcriptional regulator
Actkin_02480	COG3629	intracellular signal transduction
Actkin_02481	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_02483	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Actkin_02487	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_02489	COG0367	asparagine synthase
Actkin_02495	COG2124	cytochrome p450
Actkin_02512	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Actkin_02512	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Actkin_02514	COG1695	Transcriptional regulator
Actkin_02518	COG0531	amino acid
Actkin_02532	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_02533	COG1404	Belongs to the peptidase S8 family
Actkin_02535	COG1733	regulation of RNA biosynthetic process
Actkin_02542	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_02543	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_02544	COG1215	transferase activity, transferring glycosyl groups
Actkin_02546	COG1215	transferase activity, transferring glycosyl groups
Actkin_02548	COG1215	transferase activity, transferring glycosyl groups
Actkin_02550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_02552	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_02555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Actkin_02556	COG1573	uracil-dna glycosylase
Actkin_02557	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_02558	COG0248	Ppx GppA phosphatase
Actkin_02573	COG0488	(ABC) transporter
Actkin_02576	COG1309	transcriptional regulator
Actkin_02580	COG0765	amino acid transport
Actkin_02584	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_02584	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_02584	COG1703	isobutyryl-CoA mutase activity
Actkin_02591	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_02595	COG2723	6-phospho-beta-galactosidase activity
Actkin_02596	COG2211	Major facilitator Superfamily
Actkin_02597	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Actkin_02610	COG0659	secondary active sulfate transmembrane transporter activity
Actkin_02614	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Actkin_02616	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
Actkin_02618	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_02620	COG2329	Antibiotic biosynthesis monooxygenase
Actkin_02622	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Actkin_02623	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Actkin_02624	COG0235	Class ii aldolase
Actkin_02625	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Actkin_02630	COG0187	DNA topoisomerase II activity
Actkin_02631	COG1372	Participates in initiation and elongation during chromosome replication
Actkin_02631	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Actkin_02634	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Actkin_02640	COG3321	synthase
Actkin_02640	COG0604	alcohol dehydrogenase
Actkin_02641	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Actkin_02644	COG1819	glycosyl
Actkin_02645	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_02649	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Actkin_02662	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Actkin_02664	COG0673	inositol 2-dehydrogenase activity
Actkin_02666	COG0395	ABC-type sugar transport system, permease component
Actkin_02667	COG1175	transmembrane transport
Actkin_02672	COG3835	regulator
Actkin_02678	COG0477	Major facilitator Superfamily
Actkin_02679	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_02681	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_02689	COG1132	(ABC) transporter
Actkin_02691	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_02692	COG3275	phosphorelay sensor kinase activity
Actkin_02693	COG3279	Response regulator of the LytR AlgR family
Actkin_02695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_02697	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_02700	COG2030	dehydratase
Actkin_02700	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_02706	COG1846	Transcriptional regulator
Actkin_02707	COG3433	isochorismatase activity
Actkin_02707	COG1535	isochorismatase
Actkin_02709	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_02710	COG0395	ABC-type sugar transport system, permease component
Actkin_02711	COG1175	transmembrane transport
Actkin_02712	COG2182	Extracellular solute-binding protein
Actkin_02713	COG2188	Transcriptional regulator
Actkin_02716	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Actkin_02719	COG1414	Transcriptional regulator
Actkin_02720	COG0251	oxidation-reduction process
Actkin_02724	COG2018	Roadblock/LC7 domain
Actkin_02732	COG3033	Beta-eliminating lyase
Actkin_02734	COG1253	flavin adenine dinucleotide binding
Actkin_02735	COG1253	flavin adenine dinucleotide binding
Actkin_02738	COG0745	RESPONSE REGULATOR receiver
Actkin_02739	COG4251	negative regulation of phosphorylation
Actkin_02740	COG0784	Response regulator, receiver
Actkin_02750	COG0215	cysteine-tRNA ligase activity
Actkin_02754	COG1063	alcohol dehydrogenase
Actkin_02755	COG3387	PFAM Glycoside hydrolase 15-related
Actkin_02758	COG0140	phosphoribosyl-ATP diphosphatase activity
Actkin_02759	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Actkin_02761	COG0517	IMP dehydrogenase activity
Actkin_02761	COG1994	Peptidase M50
Actkin_02766	COG1222	aaa ATPase
Actkin_02774	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Actkin_02775	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Actkin_02776	COG1404	Belongs to the peptidase S8 family
Actkin_02777	COG0583	DNA-binding transcription factor activity
Actkin_02778	COG1597	lipid kinase activity
Actkin_02779	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Actkin_02781	COG2378	regulation of single-species biofilm formation
Actkin_02783	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Actkin_02788	COG4552	Acetyltransferase involved in intracellular survival and related
Actkin_02790	COG1595	DNA-templated transcription, initiation
Actkin_02791	COG1609	Transcriptional regulator
Actkin_02793	COG5297	Belongs to the glycosyl hydrolase family 6
Actkin_02793	COG3250	beta-galactosidase activity
Actkin_02804	COG2318	DinB family
Actkin_02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_02813	COG2205	protein histidine kinase activity
Actkin_02814	COG0745	RESPONSE REGULATOR receiver
Actkin_02816	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Actkin_02816	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Actkin_02818	COG2084	Dehydrogenase
Actkin_02828	COG2197	response regulator
Actkin_02829	COG4585	Histidine kinase
Actkin_02835	COG1073	alpha beta
Actkin_02837	COG4608	Belongs to the ABC transporter superfamily
Actkin_02841	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_02845	COG0583	DNA-binding transcription factor activity
Actkin_02847	COG4447	cellulose binding
Actkin_02847	COG3291	Pkd domain containing protein
Actkin_02847	COG5520	Belongs to the glycosyl hydrolase 30 family
Actkin_02856	COG3903	Transcriptional regulator
Actkin_02856	COG3629	intracellular signal transduction
Actkin_02857	COG1335	isochorismatase
Actkin_02860	COG2375	cellular response to nickel ion
Actkin_02860	COG1132	(ABC) transporter
Actkin_02861	COG1132	(ABC) transporter
Actkin_02862	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Actkin_02864	COG1172	Belongs to the binding-protein-dependent transport system permease family
Actkin_02865	COG1172	Belongs to the binding-protein-dependent transport system permease family
Actkin_02867	COG1879	ABC-type sugar transport system periplasmic component
Actkin_02868	COG1609	Transcriptional regulator
Actkin_02871	COG2160	L-arabinose isomerase activity
Actkin_02873	COG3401	FG-GAP repeat protein
Actkin_02874	COG3940	Belongs to the glycosyl hydrolase 43 family
Actkin_02878	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_02879	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Actkin_02887	COG0154	amidase activity
Actkin_02892	COG0346	lactoylglutathione lyase activity
Actkin_02899	COG3835	regulator
Actkin_02902	COG3209	COG3209 Rhs family protein
Actkin_02908	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Actkin_02909	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Actkin_02919	COG2755	lipolytic protein G-D-S-L family
Actkin_02922	COG3963	phosphatidate phosphatase activity
Actkin_02923	COG2409	Drug exporters of the RND superfamily
Actkin_02926	COG1113	amino acid transport
Actkin_02927	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Actkin_02930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Actkin_02934	COG1595	DNA-templated transcription, initiation
Actkin_02937	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Actkin_02941	COG3251	PFAM MbtH domain protein
Actkin_02943	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_02946	COG0861	Integral membrane protein TerC family
Actkin_02951	COG0745	RESPONSE REGULATOR receiver
Actkin_02952	COG2205	protein histidine kinase activity
Actkin_02954	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Actkin_02956	COG0673	inositol 2-dehydrogenase activity
Actkin_02958	COG1175	transmembrane transport
Actkin_02959	COG0395	ABC-type sugar transport system, permease component
Actkin_02962	COG2011	ABC-type metal ion transport system permease component
Actkin_02965	COG3693	PFAM glycoside hydrolase, family 10
Actkin_02967	COG1695	Transcriptional regulator
Actkin_02969	COG0308	aminopeptidase N
Actkin_02971	COG2197	response regulator
Actkin_02974	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Actkin_02976	COG3647	Membrane
Actkin_02977	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Actkin_02978	COG4585	Histidine kinase
Actkin_02979	COG2197	response regulator
Actkin_02983	COG2226	methyltransferase
Actkin_02983	COG2867	negative regulation of translational initiation
Actkin_02984	COG2124	cytochrome p450
Actkin_02985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Actkin_02986	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Actkin_02989	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Actkin_02994	COG1819	glycosyl
Actkin_02998	COG1657	PFAM Prenyltransferase squalene oxidase
Actkin_03000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_03002	COG3903	Transcriptional regulator
Actkin_03002	COG3629	intracellular signal transduction
Actkin_03004	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_03004	COG1672	PFAM Archaeal ATPase
Actkin_03010	COG0745	RESPONSE REGULATOR receiver
Actkin_03011	COG3903	Transcriptional regulator
Actkin_03011	COG3629	intracellular signal transduction
Actkin_03016	COG0667	Aldo Keto reductase
Actkin_03017	COG0515	serine threonine protein kinase
Actkin_03020	COG0714	Associated with various cellular activities
Actkin_03022	COG5002	protein histidine kinase activity
Actkin_03023	COG0745	RESPONSE REGULATOR receiver
Actkin_03026	COG0745	RESPONSE REGULATOR receiver
Actkin_03029	COG2814	Major facilitator Superfamily
Actkin_03041	COG1556	Lactate utilization protein
Actkin_03042	COG1139	Iron-sulfur cluster binding protein
Actkin_03043	COG0247	lactate metabolic process
Actkin_03044	COG2188	Transcriptional regulator
Actkin_03045	COG0514	ATP-dependent DNA helicase (RecQ)
Actkin_03052	COG1609	Transcriptional regulator
Actkin_03053	COG3693	PFAM glycoside hydrolase, family 10
Actkin_03053	COG3507	Belongs to the glycosyl hydrolase 43 family
Actkin_03053	COG2382	esterase
Actkin_03059	COG3845	ABC transporter
Actkin_03062	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_03064	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_03065	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_03066	COG1120	ATPase activity
Actkin_03067	COG2375	cellular response to nickel ion
Actkin_03067	COG1132	(ABC) transporter
Actkin_03071	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_03072	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_03084	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Actkin_03085	COG0577	efflux transmembrane transporter activity
Actkin_03085	COG1136	(ABC) transporter
Actkin_03087	COG1509	lysine 2,3-aminomutase activity
Actkin_03088	COG0604	alcohol dehydrogenase
Actkin_03090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Actkin_03091	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_03092	COG1607	acyl-coa hydrolase
Actkin_03093	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_03095	COG0463	Glycosyl transferase, family 2
Actkin_03098	COG1435	thymidine kinase activity
Actkin_03099	COG2270	Major facilitator Superfamily
Actkin_03103	COG5002	protein histidine kinase activity
Actkin_03103	COG5001	Diguanylate cyclase
Actkin_03104	COG4974	Belongs to the 'phage' integrase family
Actkin_03106	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_03108	COG1595	DNA-templated transcription, initiation
Actkin_03109	COG0346	lactoylglutathione lyase activity
Actkin_03114	COG0564	pseudouridine synthase activity
Actkin_03118	COG0657	acetylesterase activity
Actkin_03120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Actkin_03127	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_03138	COG1619	proteins homologs of microcin C7 resistance protein MccF
Actkin_03139	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_03141	COG0542	response to heat
Actkin_03143	COG4172	Belongs to the ABC transporter superfamily
Actkin_03144	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_03145	COG0601	transmembrane transport
Actkin_03146	COG4533	DNA binding
Actkin_03147	COG2362	D-Aminopeptidase
Actkin_03151	COG1968	undecaprenyl-diphosphatase activity
Actkin_03152	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_03153	COG0667	Aldo Keto reductase
Actkin_03158	COG0596	Alpha beta hydrolase
Actkin_03159	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_03170	COG1040	competence protein
Actkin_03171	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Actkin_03171	COG0758	DNA mediated transformation
Actkin_03188	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Actkin_03190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Actkin_03190	COG0517	IMP dehydrogenase activity
Actkin_03190	COG0617	tRNA 3'-terminal CCA addition
Actkin_03191	COG0071	Belongs to the small heat shock protein (HSP20) family
Actkin_03194	COG1017	nitric oxide dioxygenase activity
Actkin_03194	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Actkin_03195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Actkin_03196	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Actkin_03205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Actkin_03207	COG0515	serine threonine protein kinase
Actkin_03208	COG1131	(ABC) transporter
Actkin_03208	COG0842	Transport permease protein
Actkin_03208	COG1716	ATPase activity
Actkin_03210	COG3629	intracellular signal transduction
Actkin_03210	COG3903	Transcriptional regulator
Actkin_03224	COG1309	transcriptional regulator
Actkin_03230	COG0366	Alpha amylase catalytic
Actkin_03231	COG0395	ABC-type sugar transport system, permease component
Actkin_03232	COG1175	transmembrane transport
Actkin_03234	COG1846	Transcriptional regulator
Actkin_03234	COG1940	carbohydrate kinase activity
Actkin_03236	COG0456	acetyltransferase
Actkin_03238	COG0583	DNA-binding transcription factor activity
Actkin_03239	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Actkin_03240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_03243	COG1960	acyl-CoA dehydrogenase activity
Actkin_03244	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_03250	COG1917	Cupin 2, conserved barrel domain protein
Actkin_03251	COG5285	phytanoyl-CoA dioxygenase
Actkin_03253	COG1309	transcriptional regulator
Actkin_03257	COG1595	DNA-templated transcription, initiation
Actkin_03260	COG2226	methyltransferase
Actkin_03262	COG0860	N-Acetylmuramoyl-L-alanine amidase
Actkin_03262	COG2247	cell wall binding repeat
Actkin_03267	COG2124	cytochrome p450
Actkin_03269	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Actkin_03273	COG4935	Belongs to the peptidase S8 family
Actkin_03273	COG2234	aminopeptidase activity
Actkin_03275	COG2197	response regulator
Actkin_03278	COG2323	membrane
Actkin_03279	COG0789	Transcriptional regulator
Actkin_03283	COG1021	2,3-dihydroxybenzoate-AMP ligase
Actkin_03287	COG2226	methyltransferase
Actkin_03287	COG3433	isochorismatase activity
Actkin_03287	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_03288	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_03292	COG1132	(ABC) transporter
Actkin_03292	COG2375	cellular response to nickel ion
Actkin_03296	COG2124	cytochrome p450
Actkin_03299	COG0475	glutathione-regulated potassium exporter activity
Actkin_03300	COG1672	PFAM Archaeal ATPase
Actkin_03300	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_03304	COG4935	Belongs to the peptidase S8 family
Actkin_03304	COG2234	aminopeptidase activity
Actkin_03312	COG0583	DNA-binding transcription factor activity
Actkin_03313	COG2855	membrane
Actkin_03317	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Actkin_03321	COG0596	Alpha beta hydrolase
Actkin_03326	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_03327	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Actkin_03330	COG4941	Belongs to the sigma-70 factor family
Actkin_03331	COG3795	YCII-related domain
Actkin_03334	COG2311	Membrane
Actkin_03341	COG0531	amino acid
Actkin_03352	COG2066	Belongs to the glutaminase family
Actkin_03357	COG2130	NADP-dependent
Actkin_03358	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Actkin_03361	COG0477	Major facilitator Superfamily
Actkin_03363	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Actkin_03369	COG0110	maltose O-acetyltransferase activity
Actkin_03375	COG1674	ftsk spoiiie
Actkin_03384	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Actkin_03394	COG1733	regulation of RNA biosynthetic process
Actkin_03397	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Actkin_03398	COG2188	Transcriptional regulator
Actkin_03401	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Actkin_03407	COG4977	sequence-specific DNA binding
Actkin_03415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Actkin_03418	COG0798	PFAM Bile acid sodium symporter
Actkin_03420	COG1408	metallophosphoesterase
Actkin_03423	COG1404	Belongs to the peptidase S8 family
Actkin_03424	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Actkin_03428	COG2197	response regulator
Actkin_03429	COG4585	Histidine kinase
Actkin_03430	COG1136	(ABC) transporter
Actkin_03438	COG2197	response regulator
Actkin_03440	COG0443	Heat shock 70 kDa protein
Actkin_03441	COG0464	growth
Actkin_03453	COG1674	ftsk spoiiie
Actkin_03458	COG1131	(ABC) transporter
Actkin_03463	COG3842	ATPase activity
Actkin_03465	COG0395	ABC-type sugar transport system, permease component
Actkin_03468	COG1131	(ABC) transporter
Actkin_03473	COG1846	Transcriptional regulator
Actkin_03474	COG0702	epimerase
Actkin_03475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Actkin_03478	COG1120	ATPase activity
Actkin_03480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_03481	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Actkin_03485	COG0640	Transcriptional regulator
Actkin_03486	COG1309	transcriptional regulator
Actkin_03491	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Actkin_03497	COG0641	radical SAM
Actkin_03500	COG0789	Transcriptional regulator
Actkin_03501	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Actkin_03502	COG4585	Histidine kinase
Actkin_03503	COG2197	response regulator
Actkin_03514	COG1960	acyl-CoA dehydrogenase activity
Actkin_03515	COG0596	Alpha beta hydrolase
Actkin_03521	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_03524	COG2018	Roadblock/LC7 domain
Actkin_03528	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_03529	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_03530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_03530	COG0723	plastoquinol--plastocyanin reductase activity
Actkin_03543	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Actkin_03543	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Actkin_03544	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_03546	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Actkin_03546	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Actkin_03547	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Actkin_03548	COG0438	transferase activity, transferring glycosyl groups
Actkin_03550	COG0859	PFAM glycosyl transferase family 9
Actkin_03559	COG1295	ribonuclease BN
Actkin_03559	COG1959	2 iron, 2 sulfur cluster binding
Actkin_03561	COG1846	Transcriptional regulator
Actkin_03564	COG1725	Transcriptional regulator
Actkin_03565	COG1131	(ABC) transporter
Actkin_03567	COG0753	catalase activity
Actkin_03569	COG0076	glutamate decarboxylase activity
Actkin_03573	COG2409	Drug exporters of the RND superfamily
Actkin_03579	COG0542	response to heat
Actkin_03580	COG2072	flavoprotein involved in K transport
Actkin_03583	COG1247	-acetyltransferase
Actkin_03589	COG2226	methyltransferase
Actkin_03590	COG2076	Multidrug Resistance protein
Actkin_03592	COG1881	PFAM PEBP family protein
Actkin_03594	COG0596	Alpha beta hydrolase
Actkin_03596	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Actkin_03609	COG0559	Belongs to the binding-protein-dependent transport system permease family
Actkin_03611	COG0683	leucine binding
Actkin_03622	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_03623	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_03626	COG0410	ABC transporter
Actkin_03630	COG1309	transcriptional regulator
Actkin_03633	COG2124	cytochrome p450
Actkin_03640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Actkin_03642	COG3706	GGDEF domain
Actkin_03667	COG0745	RESPONSE REGULATOR receiver
Actkin_03668	COG2205	protein histidine kinase activity
Actkin_03669	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Actkin_03671	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Actkin_03675	COG2816	NAD+ diphosphatase activity
Actkin_03679	COG1960	acyl-CoA dehydrogenase activity
Actkin_03680	COG1960	acyl-CoA dehydrogenase activity
Actkin_03682	COG1501	Belongs to the glycosyl hydrolase 31 family
Actkin_03684	COG1349	DNA-binding transcription factor activity
Actkin_03685	COG1940	carbohydrate kinase activity
Actkin_03687	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Actkin_03692	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Actkin_03697	COG1674	ftsk spoiiie
Actkin_03699	COG0667	Aldo Keto reductase
Actkin_03703	COG2318	DinB family
Actkin_03711	COG0366	Alpha amylase catalytic
Actkin_03712	COG1609	Transcriptional regulator
Actkin_03717	COG1486	melibiose metabolic process
Actkin_03718	COG0395	ABC-type sugar transport system, permease component
Actkin_03719	COG1175	transmembrane transport
Actkin_03720	COG1653	transport
Actkin_03721	COG1940	carbohydrate kinase activity
Actkin_03721	COG1846	Transcriptional regulator
Actkin_03723	COG0745	RESPONSE REGULATOR receiver
Actkin_03724	COG5002	protein histidine kinase activity
Actkin_03729	COG0745	RESPONSE REGULATOR receiver
Actkin_03740	COG4585	Histidine kinase
Actkin_03746	COG1917	Cupin 2, conserved barrel domain protein
Actkin_03746	COG4977	sequence-specific DNA binding
Actkin_03752	COG1937	Protein conserved in bacteria
Actkin_03754	COG1070	Carbohydrate kinase
Actkin_03755	COG2115	Belongs to the xylose isomerase family
Actkin_03758	COG2814	Major facilitator Superfamily
Actkin_03759	COG3118	belongs to the thioredoxin family
Actkin_03761	COG0583	DNA-binding transcription factor activity
Actkin_03763	COG1953	Uracil, thiamine, allantoin
Actkin_03772	COG0009	L-threonylcarbamoyladenylate synthase
Actkin_03774	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Actkin_03776	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_03777	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_03778	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Actkin_03780	COG3384	dioxygenase
Actkin_03782	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_03783	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_03787	COG0657	acetylesterase activity
Actkin_03791	COG1063	alcohol dehydrogenase
Actkin_03800	COG1309	transcriptional regulator
Actkin_03801	COG1132	(ABC) transporter
Actkin_03802	COG1309	transcriptional regulator
Actkin_03808	COG4733	cellulase activity
Actkin_03808	COG5297	Belongs to the glycosyl hydrolase family 6
Actkin_03814	COG1609	Transcriptional regulator
Actkin_03815	COG1609	Transcriptional regulator
Actkin_03823	COG0655	NAD(P)H dehydrogenase (quinone) activity
Actkin_03828	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Actkin_03829	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Actkin_03833	COG2188	Transcriptional regulator
Actkin_03836	COG2234	aminopeptidase activity
Actkin_03836	COG4935	Belongs to the peptidase S8 family
Actkin_03845	COG3265	gluconokinase activity
Actkin_03848	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Actkin_03850	COG5002	protein histidine kinase activity
Actkin_03850	COG5001	Diguanylate cyclase
Actkin_03850	COG3447	MASE1 domain protein
Actkin_03851	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Actkin_03854	COG2151	metal-sulfur cluster biosynthetic enzyme
Actkin_03855	COG0822	iron-sulfur transferase activity
Actkin_03857	COG0396	ATPase activity
Actkin_03858	COG2146	nitrite reductase [NAD(P)H] activity
Actkin_03878	COG0109	protoheme IX farnesyltransferase activity
Actkin_03880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Actkin_03881	COG0166	Belongs to the GPI family
Actkin_03884	COG0363	glucosamine-6-phosphate deaminase activity
Actkin_03886	COG0477	Major facilitator Superfamily
Actkin_03888	COG0584	glycerophosphoryl diester phosphodiesterase
Actkin_03890	COG4585	Histidine kinase
Actkin_03896	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Actkin_03897	COG0149	triose-phosphate isomerase activity
Actkin_03898	COG0126	phosphoglycerate kinase activity
Actkin_03901	COG1481	regulation of sporulation
Actkin_03903	COG1660	Displays ATPase and GTPase activities
Actkin_03904	COG0322	excinuclease ABC activity
Actkin_03907	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Actkin_03908	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Actkin_03908	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Actkin_03912	COG2258	MOSC domain
Actkin_03913	COG0494	nUDIX hydrolase
Actkin_03916	COG0072	phenylalanine-tRNA ligase activity
Actkin_03916	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_03917	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Actkin_03918	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_03919	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Actkin_03920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Actkin_03923	COG4565	transcriptional regulatory protein
Actkin_03924	COG3290	protein histidine kinase activity
Actkin_03925	COG1301	dicarboxylic acid transport
Actkin_03932	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Actkin_03937	COG0328	RNA-DNA hybrid ribonuclease activity
Actkin_03939	COG1404	Belongs to the peptidase S8 family
Actkin_03943	COG0596	Alpha beta hydrolase
Actkin_03944	COG2124	cytochrome p450
Actkin_03946	COG0673	inositol 2-dehydrogenase activity
Actkin_03951	COG0823	Involved in the tonB-independent uptake of proteins
Actkin_03951	COG1506	peptidase
Actkin_03951	COG4946	Tricorn protease homolog
Actkin_03963	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Actkin_03970	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_03971	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Actkin_03981	COG2304	oxidoreductase activity
Actkin_03983	COG0714	Associated with various cellular activities
Actkin_03984	COG0746	molybdenum cofactor guanylyltransferase activity
Actkin_03987	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Actkin_03988	COG2188	Transcriptional regulator
Actkin_03989	COG0730	response to heat
Actkin_03990	COG1316	TRANSCRIPTIONal
Actkin_03993	COG1357	PFAM Pentapeptide repeats (8 copies)
Actkin_03997	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_04000	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_04000	COG0604	alcohol dehydrogenase
Actkin_04000	COG3321	synthase
Actkin_04002	COG2197	response regulator
Actkin_04003	COG4585	Histidine kinase
Actkin_04004	COG1136	(ABC) transporter
Actkin_04004	COG0577	efflux transmembrane transporter activity
Actkin_04006	COG3883	PFAM NLP P60 protein
Actkin_04006	COG0791	NLP P60 protein
Actkin_04009	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Actkin_04010	COG3629	intracellular signal transduction
Actkin_04010	COG3903	Transcriptional regulator
Actkin_04012	COG0702	epimerase
Actkin_04014	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Actkin_04015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Actkin_04016	COG3572	ergothioneine biosynthetic process
Actkin_04017	COG1309	transcriptional regulator
Actkin_04020	COG1253	flavin adenine dinucleotide binding
Actkin_04023	COG3469	chitinase activity
Actkin_04026	COG4585	Histidine kinase
Actkin_04027	COG2197	response regulator
Actkin_04030	COG2304	oxidoreductase activity
Actkin_04039	COG3903	Transcriptional regulator
Actkin_04039	COG3629	intracellular signal transduction
Actkin_04040	COG0656	L-ascorbic acid biosynthetic process
Actkin_04041	COG1185	polyribonucleotide nucleotidyltransferase activity
Actkin_04044	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Actkin_04044	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Actkin_04048	COG1716	ATPase activity
Actkin_04050	COG0693	protein deglycase activity
Actkin_04052	COG1024	Enoyl-CoA hydratase
Actkin_04066	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Actkin_04066	COG0237	dephospho-CoA kinase activity
Actkin_04068	COG0539	negative regulation of cytoplasmic translation
Actkin_04071	COG0667	Aldo Keto reductase
Actkin_04073	COG1511	domain protein
Actkin_04077	COG0778	Nitroreductase
Actkin_04087	COG1366	Belongs to the anti-sigma-factor antagonist family
Actkin_04089	COG0859	PFAM glycosyl transferase family 9
Actkin_04097	COG1234	tRNA 3'-trailer cleavage
Actkin_04101	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Actkin_04104	COG0395	ABC-type sugar transport system, permease component
Actkin_04109	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_04109	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Actkin_04111	COG0439	Biotin carboxylase
Actkin_04113	COG1793	dna ligase
Actkin_04115	COG1278	Cold shock
Actkin_04124	COG1937	Protein conserved in bacteria
Actkin_04128	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Actkin_04129	COG2226	methyltransferase
Actkin_04131	COG0697	spore germination
Actkin_04132	COG1846	Transcriptional regulator
Actkin_04140	COG2259	Doxx family
Actkin_04146	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Actkin_04149	COG0583	DNA-binding transcription factor activity
Actkin_04150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_04151	COG1846	Transcriptional regulator
Actkin_04156	COG4257	antibiotic catabolic process
Actkin_04157	COG0110	maltose O-acetyltransferase activity
Actkin_04160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Actkin_04164	COG0596	Alpha beta hydrolase
Actkin_04167	COG0596	Alpha beta hydrolase
Actkin_04171	COG0488	(ABC) transporter
Actkin_04172	COG2124	cytochrome p450
Actkin_04185	COG0702	epimerase
Actkin_04186	COG3321	synthase
Actkin_04186	COG0604	alcohol dehydrogenase
Actkin_04194	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_04194	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Actkin_04195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Actkin_04198	COG0277	FAD linked oxidase domain protein
Actkin_04199	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_04202	COG1470	cell adhesion involved in biofilm formation
Actkin_04202	COG0366	Alpha amylase catalytic
Actkin_04206	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Actkin_04209	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_04212	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Actkin_04213	COG4172	Belongs to the ABC transporter superfamily
Actkin_04221	COG1595	DNA-templated transcription, initiation
Actkin_04223	COG1252	NADH dehydrogenase
Actkin_04224	COG0583	DNA-binding transcription factor activity
Actkin_04230	COG1404	Belongs to the peptidase S8 family
Actkin_04232	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_04236	COG4941	Belongs to the sigma-70 factor family
Actkin_04246	COG3973	AAA domain
Actkin_04247	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Actkin_04250	COG1120	ATPase activity
Actkin_04251	COG4139	cobalamin transport
Actkin_04258	COG1120	ATPase activity
Actkin_04259	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Actkin_04264	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Actkin_04265	COG1120	ATPase activity
Actkin_04273	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_04278	COG0747	negative chemotaxis
Actkin_04280	COG0444	Belongs to the ABC transporter superfamily
Actkin_04281	COG4172	Belongs to the ABC transporter superfamily
Actkin_04290	COG1309	transcriptional regulator
Actkin_04291	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_04295	COG1309	transcriptional regulator
Actkin_04319	COG0443	Heat shock 70 kDa protein
Actkin_04323	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Actkin_04336	COG3883	PFAM NLP P60 protein
Actkin_04336	COG0791	NLP P60 protein
Actkin_04346	COG1475	DNA binding
Actkin_04353	COG3340	Belongs to the peptidase S51 family
Actkin_04361	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Actkin_04362	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Actkin_04365	COG1518	maintenance of DNA repeat elements
Actkin_04370	COG1203	CRISPR-associated helicase, Cas3
Actkin_04376	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Actkin_04377	COG4865	methylaspartate mutase activity
Actkin_04381	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_04383	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_04384	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_04386	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_04386	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_04389	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Actkin_04390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Actkin_04391	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_04399	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_04400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_04407	COG2226	methyltransferase
Actkin_04408	COG0586	Pfam SNARE associated Golgi protein
Actkin_04409	COG4585	Histidine kinase
Actkin_04410	COG2197	response regulator
Actkin_04418	COG0644	oxidoreductase
Actkin_04419	COG4221	oxidoreductase activity
Actkin_04421	COG0402	S-adenosylhomocysteine deaminase activity
Actkin_04423	COG0477	Major facilitator Superfamily
Actkin_04436	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_04440	COG0673	inositol 2-dehydrogenase activity
Actkin_04441	COG1609	Transcriptional regulator
Actkin_04442	COG0640	Transcriptional regulator
Actkin_04446	COG4585	Histidine kinase
Actkin_04447	COG2197	response regulator
Actkin_04449	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Actkin_04450	COG4208	sulfate ABC transporter
Actkin_04452	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Actkin_04453	COG1414	Transcriptional regulator
Actkin_04463	COG2409	Drug exporters of the RND superfamily
Actkin_04465	COG3795	YCII-related domain
Actkin_04466	COG4941	Belongs to the sigma-70 factor family
Actkin_04468	COG1278	Cold shock
Actkin_04469	COG0300	oxidoreductase activity
Actkin_04470	COG0667	Aldo Keto reductase
Actkin_04473	COG2353	YceI-like domain
Actkin_04486	COG0514	ATP-dependent DNA helicase (RecQ)
Actkin_04488	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Actkin_04488	COG2010	Cytochrome c
Actkin_04490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Actkin_04499	COG3030	protein affecting phage T7 exclusion by the F plasmid
Actkin_04500	COG0067	glutamate synthase
Actkin_04500	COG0070	glutamate synthase
Actkin_04500	COG0069	glutamate synthase activity
Actkin_04505	COG1660	Displays ATPase and GTPase activities
Actkin_04508	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Actkin_04509	COG1846	Transcriptional regulator
Actkin_04510	COG1764	response to oxidative stress
Actkin_04513	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Actkin_04516	COG5297	Belongs to the glycosyl hydrolase family 6
Actkin_04517	COG1760	l-serine dehydratase
Actkin_04518	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Actkin_04519	COG0509	glycine decarboxylation via glycine cleavage system
Actkin_04520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Actkin_04521	COG1122	ATPase activity
Actkin_04524	COG0310	cobalt ion transport
Actkin_04531	COG1960	acyl-CoA dehydrogenase activity
Actkin_04534	COG1595	DNA-templated transcription, initiation
Actkin_04537	COG2018	Roadblock/LC7 domain
Actkin_04540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_04542	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Actkin_04543	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Actkin_04547	COG1136	(ABC) transporter
Actkin_04549	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_04559	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_04565	COG2814	Major facilitator Superfamily
Actkin_04568	COG1566	PFAM secretion protein HlyD family protein
Actkin_04572	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Actkin_04573	COG1960	acyl-CoA dehydrogenase activity
Actkin_04579	COG2197	response regulator
Actkin_04604	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_04606	COG2197	response regulator
Actkin_04611	COG1946	Acyl-CoA thioesterase
Actkin_04616	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Actkin_04618	COG0067	glutamate synthase
Actkin_04618	COG0069	glutamate synthase activity
Actkin_04618	COG0070	glutamate synthase
Actkin_04620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Actkin_04622	COG0159	tryptophan synthase activity
Actkin_04623	COG0133	tryptophan synthase activity
Actkin_04624	COG0134	indole-3-glycerol-phosphate synthase activity
Actkin_04626	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Actkin_04628	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Actkin_04630	COG0107	imidazoleglycerol-phosphate synthase activity
Actkin_04636	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Actkin_04637	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Actkin_04640	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Actkin_04645	COG0131	Imidazoleglycerol-phosphate dehydratase
Actkin_04646	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Actkin_04647	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Actkin_04648	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Actkin_04652	COG0157	Belongs to the NadC ModD family
Actkin_04654	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Actkin_04659	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Actkin_04660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Actkin_04662	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Actkin_04665	COG2124	cytochrome p450
Actkin_04671	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Actkin_04672	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Actkin_04674	COG1872	DUF167
Actkin_04679	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Actkin_04689	COG1799	cell septum assembly
Actkin_04698	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Actkin_04699	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Actkin_04701	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Actkin_04702	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Actkin_04705	COG0768	penicillin binding
Actkin_04707	COG0275	rRNA processing
Actkin_04708	COG2001	Belongs to the MraZ family
Actkin_04709	COG0714	Associated with various cellular activities
Actkin_04711	COG1305	Transglutaminase-like
Actkin_04714	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Actkin_04714	COG1796	DNA polymerase
Actkin_04723	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Actkin_04724	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_04725	COG1192	Involved in chromosome partitioning
Actkin_04726	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Actkin_04729	COG0167	dihydroorotate dehydrogenase activity
Actkin_04730	COG2233	PERMEase
Actkin_04733	COG1842	Phage shock protein A
Actkin_04734	COG1396	sequence-specific DNA binding
Actkin_04735	COG1058	Belongs to the CinA family
Actkin_04735	COG1546	Belongs to the CinA family
Actkin_04737	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Actkin_04739	COG0183	Belongs to the thiolase family
Actkin_04740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Actkin_04743	COG1674	ftsk spoiiie
Actkin_04745	COG0366	Alpha amylase catalytic
Actkin_04749	COG0659	secondary active sulfate transmembrane transporter activity
Actkin_04753	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Actkin_04754	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Actkin_04756	COG0515	serine threonine protein kinase
Actkin_04761	COG3214	Protein conserved in bacteria
Actkin_04762	COG0697	spore germination
Actkin_04770	COG0477	Major facilitator Superfamily
Actkin_04771	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Actkin_04773	COG0697	spore germination
Actkin_04774	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Actkin_04775	COG0137	argininosuccinate synthase activity
Actkin_04778	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Actkin_04780	COG1185	polyribonucleotide nucleotidyltransferase activity
Actkin_04781	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Actkin_04785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Actkin_04786	COG2223	nitrite transmembrane transporter activity
Actkin_04789	COG1271	oxidase subunit
Actkin_04792	COG3842	ATPase activity
Actkin_04793	COG0395	ABC-type sugar transport system, permease component
Actkin_04795	COG1653	transport
Actkin_04803	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Actkin_04805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Actkin_04805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Actkin_04808	COG0779	Required for maturation of 30S ribosomal subunits
Actkin_04816	COG0442	prolyl-tRNA aminoacylation
Actkin_04817	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Actkin_04817	COG0235	Class ii aldolase
Actkin_04819	COG3022	response to hydroperoxide
Actkin_04821	COG0513	Belongs to the DEAD box helicase family
Actkin_04824	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Actkin_04824	COG1648	precorrin-2 dehydrogenase activity
Actkin_04825	COG0745	RESPONSE REGULATOR receiver
Actkin_04826	COG1404	Belongs to the peptidase S8 family
Actkin_04826	COG4412	M6 family metalloprotease domain protein
Actkin_04832	COG0156	8-amino-7-oxononanoate synthase activity
Actkin_04838	COG1881	PFAM PEBP family protein
Actkin_04841	COG1492	cobalamin metabolic process
Actkin_04845	COG0456	acetyltransferase
Actkin_04846	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Actkin_04847	COG0750	zinc metalloprotease
Actkin_04848	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Actkin_04853	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Actkin_04855	COG2226	methyltransferase
Actkin_04858	COG0233	cytoplasmic translational termination
Actkin_04859	COG0528	UMP kinase activity
Actkin_04860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Actkin_04861	COG0052	Belongs to the universal ribosomal protein uS2 family
Actkin_04864	COG1191	sigma factor activity
Actkin_04868	COG0792	nuclease activity
Actkin_04870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Actkin_04871	COG0681	Belongs to the peptidase S26 family
Actkin_04872	COG0681	Belongs to the peptidase S26 family
Actkin_04873	COG0681	Belongs to the peptidase S26 family
Actkin_04874	COG0335	large ribosomal subunit rRNA binding
Actkin_04875	COG0336	Belongs to the RNA methyltransferase TrmD family
Actkin_04876	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Actkin_04879	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Actkin_04883	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Actkin_04885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Actkin_04889	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Actkin_04893	COG0302	gtp cyclohydrolase
Actkin_04895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Actkin_04897	COG2508	Transcriptional regulator
Actkin_04898	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Actkin_04899	COG4266	Belongs to the allantoicase family
Actkin_04900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Actkin_04902	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Actkin_04904	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Actkin_04905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_04909	COG1196	nuclear chromosome segregation
Actkin_04912	COG1254	Belongs to the acylphosphatase family
Actkin_04914	COG2340	Cysteine-rich secretory protein family
Actkin_04916	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Actkin_04917	COG0571	ribonuclease III activity
Actkin_04918	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Actkin_04924	COG0742	ribosomal rna small subunit methyltransferase
Actkin_04925	COG3973	AAA domain
Actkin_04926	COG0640	Transcriptional regulator
Actkin_04927	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Actkin_04930	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Actkin_04941	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Actkin_04943	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Actkin_04944	COG1461	Dihydroxyacetone kinase
Actkin_04946	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_04949	COG1595	DNA-templated transcription, initiation
Actkin_04951	COG0626	cystathionine gamma-synthase activity
Actkin_04952	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Actkin_04954	COG1920	GTP binding
Actkin_04956	COG0494	nUDIX hydrolase
Actkin_04956	COG0406	alpha-ribazole phosphatase activity
Actkin_04958	COG0066	3-isopropylmalate dehydratase activity
Actkin_04959	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Actkin_04963	COG0546	phosphoglycolate phosphatase activity
Actkin_04964	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Actkin_04974	COG0641	radical SAM
Actkin_04979	COG0179	Fumarylacetoacetate (FAA) hydrolase
Actkin_04980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Actkin_04983	COG0473	3-isopropylmalate dehydrogenase activity
Actkin_04990	COG0129	dihydroxy-acid dehydratase activity
Actkin_04993	COG0440	acetolactate synthase activity
Actkin_04994	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Actkin_04997	COG2259	Doxx family
Actkin_05000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Actkin_05002	COG0154	amidase activity
Actkin_05003	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Actkin_05004	COG0849	cell division
Actkin_05005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Actkin_05007	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Actkin_05010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Actkin_05011	COG1053	succinate dehydrogenase
Actkin_05014	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Actkin_05017	COG0577	efflux transmembrane transporter activity
Actkin_05017	COG1136	(ABC) transporter
Actkin_05024	COG0482	sulfurtransferase activity
Actkin_05026	COG2814	Major facilitator Superfamily
Actkin_05029	COG2205	protein histidine kinase activity
Actkin_05030	COG0745	RESPONSE REGULATOR receiver
Actkin_05035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Actkin_05041	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_05045	COG2226	methyltransferase
Actkin_05046	COG0110	maltose O-acetyltransferase activity
Actkin_05054	COG1119	ATPase activity
Actkin_05057	COG0135	phosphoribosylanthranilate isomerase activity
Actkin_05060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Actkin_05061	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Actkin_05063	COG0366	Alpha amylase catalytic
Actkin_05064	COG0366	Alpha amylase catalytic
Actkin_05065	COG0058	SHG alpha-glucan phosphorylase activity
Actkin_05071	COG1846	Transcriptional regulator
Actkin_05073	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_05077	COG1131	(ABC) transporter
Actkin_05079	COG1703	isobutyryl-CoA mutase activity
Actkin_05080	COG0183	Belongs to the thiolase family
Actkin_05081	COG0346	lactoylglutathione lyase activity
Actkin_05083	COG0583	DNA-binding transcription factor activity
Actkin_05085	COG3104	oligopeptide transport
Actkin_05091	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Actkin_05092	COG4106	trans-aconitate 2-methyltransferase activity
Actkin_05097	COG1250	3-hydroxyacyl-CoA dehydrogenase
Actkin_05101	COG2376	Dihydroxyacetone kinase
Actkin_05103	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Actkin_05104	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Actkin_05106	COG0405	Gamma-glutamyltransferase
Actkin_05108	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_05108	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Actkin_05110	COG0765	amino acid transport
Actkin_05111	COG0765	amino acid transport
Actkin_05112	COG1126	abc transporter atp-binding protein
Actkin_05114	COG1024	Enoyl-CoA hydratase
Actkin_05118	COG4585	Histidine kinase
Actkin_05119	COG2197	response regulator
Actkin_05126	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Actkin_05127	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Actkin_05128	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Actkin_05129	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Actkin_05130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Actkin_05131	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Actkin_05132	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Actkin_05133	COG0356	it plays a direct role in the translocation of protons across the membrane
Actkin_05135	COG2226	methyltransferase
Actkin_05141	COG2226	methyltransferase
Actkin_05147	COG2890	protein-(glutamine-N5) methyltransferase activity
Actkin_05150	COG0254	rRNA binding
Actkin_05155	COG0083	homoserine kinase activity
Actkin_05156	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Actkin_05158	COG0019	diaminopimelate decarboxylase activity
Actkin_05159	COG0018	arginyl-trna synthetase
Actkin_05164	COG1902	pentaerythritol trinitrate reductase activity
Actkin_05165	COG1846	Transcriptional regulator
Actkin_05168	COG0659	secondary active sulfate transmembrane transporter activity
Actkin_05169	COG3002	Belongs to the UPF0753 family
Actkin_05170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Actkin_05179	COG3842	ATPase activity
Actkin_05184	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Actkin_05202	COG3973	AAA domain
Actkin_05203	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_05204	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Actkin_05206	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Actkin_05208	COG3903	Transcriptional regulator
Actkin_05208	COG3629	intracellular signal transduction
Actkin_05214	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_05222	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Actkin_05226	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_05227	COG1960	acyl-CoA dehydrogenase activity
Actkin_05232	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Actkin_05233	COG0477	Major facilitator Superfamily
Actkin_05238	COG0596	Alpha beta hydrolase
Actkin_05239	COG2755	lipolytic protein G-D-S-L family
Actkin_05239	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Actkin_05241	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Actkin_05247	COG2814	Major facilitator Superfamily
Actkin_05251	COG2022	thiamine diphosphate biosynthetic process
Actkin_05253	COG0159	tryptophan synthase activity
Actkin_05254	COG0134	indole-3-glycerol-phosphate synthase activity
Actkin_05256	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_05258	COG2226	methyltransferase
Actkin_05263	COG2124	cytochrome p450
Actkin_05272	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Actkin_05273	COG0569	domain protein
Actkin_05276	COG1510	regulation of RNA biosynthetic process
Actkin_05293	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Actkin_05296	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Actkin_05308	COG0395	ABC-type sugar transport system, permease component
Actkin_05312	COG2815	serine threonine protein kinase
Actkin_05312	COG0515	serine threonine protein kinase
Actkin_05317	COG2076	Multidrug Resistance protein
Actkin_05318	COG0242	peptide deformylase activity
Actkin_05319	COG4948	Mandelate Racemase Muconate Lactonizing
Actkin_05321	COG0667	Aldo Keto reductase
Actkin_05335	COG5522	Integral membrane protein (intg_mem_TP0381)
Actkin_05340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Actkin_05342	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Actkin_05343	COG0109	protoheme IX farnesyltransferase activity
Actkin_05344	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Actkin_05348	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_05350	COG0673	inositol 2-dehydrogenase activity
Actkin_05352	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_05368	COG2226	methyltransferase
Actkin_05369	COG1324	tolerance protein
Actkin_05386	COG0626	cystathionine gamma-synthase activity
Actkin_05405	COG2226	methyltransferase
Actkin_05409	COG1960	acyl-CoA dehydrogenase activity
Actkin_05414	COG1960	acyl-CoA dehydrogenase activity
Actkin_05416	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_05417	COG2755	lipolytic protein G-D-S-L family
Actkin_05420	COG2203	Gaf domain
Actkin_05420	COG3706	GGDEF domain
Actkin_05420	COG4251	negative regulation of phosphorylation
Actkin_05420	COG5001	Diguanylate cyclase
Actkin_05423	COG2755	lipolytic protein G-D-S-L family
Actkin_05424	COG2508	Transcriptional regulator
Actkin_05424	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Actkin_05425	COG0686	Belongs to the AlaDH PNT family
Actkin_05433	COG0508	dehydrogenase complex catalyzes the overall conversion of
Actkin_05433	COG0567	Dehydrogenase, E1 component
Actkin_05438	COG0667	Aldo Keto reductase
Actkin_05442	COG1228	amidohydrolase
Actkin_05445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Actkin_05446	COG2986	histidine ammonia-lyase
Actkin_05449	COG1414	Transcriptional regulator
Actkin_05461	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Actkin_05465	COG2186	Transcriptional regulator
Actkin_05475	COG0406	alpha-ribazole phosphatase activity
Actkin_05478	COG1597	lipid kinase activity
Actkin_05481	COG5662	AntiSigma factor
Actkin_05482	COG1595	DNA-templated transcription, initiation
Actkin_05486	COG2135	peptidase activity
Actkin_05487	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Actkin_05488	COG1162	GTPase activity
Actkin_05491	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_05495	COG1011	Hydrolase
Actkin_05496	COG0653	protein targeting
Actkin_05499	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Actkin_05501	COG5002	protein histidine kinase activity
Actkin_05502	COG0745	RESPONSE REGULATOR receiver
Actkin_05505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Actkin_05510	COG1482	cell wall glycoprotein biosynthetic process
Actkin_05512	COG2835	tetraacyldisaccharide 4'-kinase activity
Actkin_05513	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Actkin_05518	COG1994	Peptidase M50
Actkin_05519	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Actkin_05520	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Actkin_05520	COG0778	Nitroreductase
Actkin_05525	COG0662	Cupin 2, conserved barrel domain protein
Actkin_05525	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Actkin_05529	COG0438	transferase activity, transferring glycosyl groups
Actkin_05536	COG0438	transferase activity, transferring glycosyl groups
Actkin_05539	COG1316	TRANSCRIPTIONal
Actkin_05540	COG1316	TRANSCRIPTIONal
Actkin_05544	COG2318	DinB family
Actkin_05547	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Actkin_05559	COG2205	protein histidine kinase activity
Actkin_05560	COG0745	RESPONSE REGULATOR receiver
Actkin_05561	COG0483	inositol monophosphate 1-phosphatase activity
Actkin_05566	COG1473	amidohydrolase
Actkin_05566	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Actkin_05633	COG0515	serine threonine protein kinase
Actkin_05640	COG4770	biotin carboxylase activity
Actkin_05642	COG1301	dicarboxylic acid transport
Actkin_05646	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Actkin_05648	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Actkin_05648	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Actkin_05655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Actkin_05656	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Actkin_05657	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Actkin_05663	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Actkin_05665	COG0702	epimerase
Actkin_05666	COG1733	regulation of RNA biosynthetic process
Actkin_05674	COG0667	Aldo Keto reductase
Actkin_05675	COG0789	Transcriptional regulator
Actkin_05677	COG3509	depolymerase
Actkin_05678	COG3654	unkown
Actkin_05685	COG2226	methyltransferase
Actkin_05687	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Actkin_05688	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_05694	COG3220	belongs to the UPF0276 family
Actkin_05700	COG3883	PFAM NLP P60 protein
Actkin_05700	COG0791	NLP P60 protein
Actkin_05705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Actkin_05707	COG0477	Major facilitator Superfamily
Actkin_05714	COG1079	Belongs to the binding-protein-dependent transport system permease family
Actkin_05715	COG4603	Belongs to the binding-protein-dependent transport system permease family
Actkin_05716	COG3845	ABC transporter
Actkin_05717	COG1744	ABC transporter substrate-binding protein PnrA-like
Actkin_05720	COG2009	succinate dehydrogenase
Actkin_05722	COG1053	succinate dehydrogenase
Actkin_05723	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Actkin_05735	COG3507	Belongs to the glycosyl hydrolase 43 family
Actkin_05736	COG0673	inositol 2-dehydrogenase activity
Actkin_05737	COG1879	ABC-type sugar transport system periplasmic component
Actkin_05738	COG1172	Belongs to the binding-protein-dependent transport system permease family
Actkin_05739	COG1129	ABC transporter
Actkin_05743	COG1940	carbohydrate kinase activity
Actkin_05748	COG3629	intracellular signal transduction
Actkin_05748	COG3903	Transcriptional regulator
Actkin_05752	COG0439	Biotin carboxylase
Actkin_05753	COG0511	ligase activity, forming carbon-carbon bonds
Actkin_05754	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Actkin_05754	COG0825	malonyl-CoA metabolic process
Actkin_05758	COG2124	cytochrome p450
Actkin_05767	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_05770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Actkin_05771	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Actkin_05777	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_05779	COG1597	lipid kinase activity
Actkin_05783	COG3268	Saccharopine dehydrogenase
Actkin_05784	COG1940	carbohydrate kinase activity
Actkin_05786	COG1686	Belongs to the peptidase S11 family
Actkin_05788	COG1295	ribonuclease BN
Actkin_05789	COG0180	Tryptophanyl-tRNA synthetase
Actkin_05798	COG0477	Major facilitator Superfamily
Actkin_05801	COG2815	serine threonine protein kinase
Actkin_05801	COG0515	serine threonine protein kinase
Actkin_05805	COG0039	L-malate dehydrogenase activity
Actkin_05808	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Actkin_05816	COG0587	DNA-directed DNA polymerase activity
Actkin_05826	COG0045	succinate-CoA ligase (ADP-forming) activity
Actkin_05829	COG0739	heme binding
Actkin_05831	COG1605	Chorismate mutase
Actkin_05831	COG0077	Prephenate dehydratase
Actkin_05836	COG0515	serine threonine protein kinase
Actkin_05837	COG2815	serine threonine protein kinase
Actkin_05837	COG0515	serine threonine protein kinase
Actkin_05838	COG0583	DNA-binding transcription factor activity
Actkin_05844	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Actkin_05844	COG0519	Catalyzes the synthesis of GMP from XMP
Actkin_05845	COG1012	belongs to the aldehyde dehydrogenase family
Actkin_05846	COG0277	FAD linked oxidase domain protein
Actkin_05848	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Actkin_05850	COG2814	Major facilitator Superfamily
Actkin_05853	COG0516	GMP reductase activity
Actkin_05860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Actkin_05863	COG0459	protein refolding
Actkin_05864	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Actkin_05868	COG3540	Alkaline phosphatase
Actkin_05870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Actkin_05871	COG0456	acetyltransferase
Actkin_05873	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_05874	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Actkin_05874	COG0825	malonyl-CoA metabolic process
Actkin_05875	COG0802	atpase or kinase
Actkin_05877	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Actkin_05887	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Actkin_05888	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Actkin_05889	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Actkin_05893	COG1674	ftsk spoiiie
Actkin_05896	COG1404	Belongs to the peptidase S8 family
Actkin_05904	COG0203	ribosomal protein L17
Actkin_05905	COG0202	RNA polymerase activity
Actkin_05906	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Actkin_05907	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Actkin_05909	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Actkin_05910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Actkin_05911	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Actkin_05912	COG0667	Aldo Keto reductase
Actkin_05914	COG0563	adenylate kinase activity
Actkin_05916	COG0200	Binds to the 23S rRNA
Actkin_05917	COG1841	ribosomal large subunit assembly
Actkin_05918	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Actkin_05919	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Actkin_05920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Actkin_05921	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Actkin_05922	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Actkin_05923	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Actkin_05924	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Actkin_05925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Actkin_05926	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Actkin_05927	COG0255	Belongs to the universal ribosomal protein uL29 family
Actkin_05928	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Actkin_05929	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Actkin_05930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Actkin_05931	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Actkin_05932	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Actkin_05933	COG0089	rRNA binding
Actkin_05934	COG0088	Forms part of the polypeptide exit tunnel
Actkin_05935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Actkin_05936	COG0051	transcription antitermination factor activity, RNA binding
Actkin_05937	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Actkin_05938	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Actkin_05939	COG0049	tRNA binding
Actkin_05940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Actkin_05951	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Actkin_05952	COG0085	RNA polymerase activity
Actkin_05956	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Actkin_05961	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Actkin_05970	COG0081	regulation of translation
Actkin_05974	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_05976	COG2030	dehydratase
Actkin_05988	COG2267	carboxylic ester hydrolase activity
Actkin_05991	COG1666	GTP binding
Actkin_05994	COG0501	Belongs to the peptidase M48B family
Actkin_05999	COG1834	amidinotransferase
Actkin_06000	COG1522	sequence-specific DNA binding
Actkin_06002	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Actkin_06002	COG0674	pyruvate-flavodoxin oxidoreductase activity
Actkin_06003	COG1013	pyruvate-flavodoxin oxidoreductase activity
Actkin_06006	COG0142	geranyltranstransferase activity
Actkin_06007	COG1007	ATP synthesis coupled electron transport
Actkin_06010	COG0713	ATP synthesis coupled electron transport
Actkin_06011	COG0839	Belongs to the complex I subunit 6 family
Actkin_06012	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Actkin_06013	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Actkin_06014	COG1034	ATP synthesis coupled electron transport
Actkin_06017	COG0649	NAD binding
Actkin_06018	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Actkin_06019	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Actkin_06021	COG0644	oxidoreductase
Actkin_06026	COG2226	methyltransferase
Actkin_06027	COG0438	transferase activity, transferring glycosyl groups
Actkin_06028	COG0438	transferase activity, transferring glycosyl groups
Actkin_06031	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Actkin_06032	COG2151	metal-sulfur cluster biosynthetic enzyme
Actkin_06033	COG3396	Phenylacetate-CoA oxygenase
Actkin_06034	COG3460	Phenylacetate-CoA oxygenase
Actkin_06035	COG3396	Phenylacetate-CoA oxygenase
Actkin_06038	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Actkin_06039	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Actkin_06043	COG3903	Transcriptional regulator
Actkin_06043	COG3629	intracellular signal transduction
Actkin_06051	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Actkin_06054	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Actkin_06056	COG0785	Cytochrome C biogenesis protein
Actkin_06058	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Actkin_06059	COG0406	alpha-ribazole phosphatase activity
Actkin_06060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Actkin_06069	COG0113	porphobilinogen synthase activity
Actkin_06070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Actkin_06070	COG1648	precorrin-2 dehydrogenase activity
Actkin_06071	COG0181	hydroxymethylbilane synthase activity
Actkin_06072	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Actkin_06073	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Actkin_06077	COG0318	PFAM AMP-dependent synthetase and ligase
Actkin_06078	COG1595	DNA-templated transcription, initiation
Actkin_06084	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Actkin_06086	COG0506	proline dehydrogenase activity
Actkin_06087	COG1082	Xylose isomerase domain protein TIM barrel
Actkin_06091	COG5002	protein histidine kinase activity
Actkin_06092	COG0588	phosphoglycerate mutase activity
Actkin_06095	COG0438	transferase activity, transferring glycosyl groups
Actkin_06098	COG1376	ErfK ybiS ycfS ynhG family protein
Actkin_06100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Actkin_06103	COG2197	response regulator
Actkin_06112	COG3973	AAA domain
Actkin_06113	COG2843	Capsule synthesis protein
Actkin_06126	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Actkin_06127	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Actkin_06128	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Actkin_06128	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Actkin_06130	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_06136	COG1136	(ABC) transporter
Actkin_06140	COG2733	membrane
Actkin_06143	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_06145	COG0387	Pfam Sodium calcium exchanger
Actkin_06151	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Actkin_06152	COG0438	transferase activity, transferring glycosyl groups
Actkin_06160	COG2244	polysaccharide biosynthetic process
Actkin_06161	COG0463	Glycosyl transferase, family 2
Actkin_06162	COG1595	DNA-templated transcription, initiation
Actkin_06171	COG0367	asparagine synthase
Actkin_06175	COG0673	inositol 2-dehydrogenase activity
Actkin_06182	COG1278	Cold shock
Actkin_06186	COG1408	metallophosphoesterase
Actkin_06187	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_06189	COG0515	serine threonine protein kinase
Actkin_06197	COG2255	four-way junction helicase activity
Actkin_06208	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Actkin_06215	COG0673	inositol 2-dehydrogenase activity
Actkin_06222	COG0704	Plays a role in the regulation of phosphate uptake
Actkin_06223	COG1316	TRANSCRIPTIONal
Actkin_06231	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Actkin_06235	COG0456	acetyltransferase
Actkin_06235	COG0454	-acetyltransferase
Actkin_06236	COG0745	RESPONSE REGULATOR receiver
Actkin_06240	COG2897	thiosulfate sulfurtransferase activity
Actkin_06242	COG4044	May play a role in the intracellular transport of hydrophobic ligands
Actkin_06246	COG0735	belongs to the Fur family
Actkin_06248	COG3246	L-lysine catabolic process to acetate
Actkin_06256	COG3290	protein histidine kinase activity
Actkin_06257	COG4565	transcriptional regulatory protein
Actkin_06271	COG1472	Belongs to the glycosyl hydrolase 3 family
Actkin_06273	COG2814	Major facilitator Superfamily
Actkin_06277	COG2271	Major facilitator Superfamily
Actkin_06279	COG2181	nitrate reductase activity
Actkin_06279	COG0247	lactate metabolic process
Actkin_06286	COG0542	response to heat
Actkin_06288	COG2871	sodium ion transport
Actkin_06289	COG0789	Transcriptional regulator
Actkin_06290	COG0484	heat shock protein binding
Actkin_06291	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Actkin_06292	COG0443	Heat shock 70 kDa protein
Actkin_06296	COG0277	FAD linked oxidase domain protein
Actkin_06301	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Actkin_06303	COG0586	Pfam SNARE associated Golgi protein
Actkin_06305	COG1609	Transcriptional regulator
Actkin_06308	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_06310	COG0243	molybdopterin cofactor binding
Actkin_06313	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Actkin_06318	COG4221	oxidoreductase activity
Actkin_06325	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_06329	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Actkin_06331	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Actkin_06334	COG1595	DNA-templated transcription, initiation
Actkin_06336	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Actkin_06338	COG0436	Aminotransferase
Actkin_06349	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Actkin_06350	COG0047	phosphoribosylformylglycinamidine synthase activity
Actkin_06351	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Actkin_06353	COG0456	acetyltransferase
Actkin_06354	COG1960	acyl-CoA dehydrogenase activity
Actkin_06355	COG2197	response regulator
Actkin_06363	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Actkin_06371	COG0584	glycerophosphoryl diester phosphodiesterase
Actkin_06372	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Actkin_06376	COG1309	transcriptional regulator
Actkin_06379	COG0508	dehydrogenase complex catalyzes the overall conversion of
Actkin_06380	COG0022	dehydrogenase e1 component
Actkin_06382	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Actkin_06383	COG2319	Wd-40 repeat
Actkin_06386	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Actkin_06387	COG0765	amino acid transport
Actkin_06390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Actkin_06392	COG4935	Belongs to the peptidase S8 family
Actkin_06392	COG2234	aminopeptidase activity
Actkin_06393	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Actkin_06398	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_06399	COG0183	Belongs to the thiolase family
Actkin_06406	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Actkin_06408	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Actkin_06409	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Actkin_06411	COG4585	Histidine kinase
Actkin_06413	COG3311	Transcriptional regulator
Actkin_06415	COG1569	PIN domain
Actkin_06416	COG1028	Short-chain dehydrogenase reductase Sdr
Actkin_06422	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Actkin_06423	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
Actkin_06424	COG0402	S-adenosylhomocysteine deaminase activity
Actkin_06427	COG4221	oxidoreductase activity
Actkin_06429	COG1260	myo-inositol-1-phosphate synthase
Actkin_06432	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Actkin_06439	COG0360	Binds together with S18 to 16S ribosomal RNA
Actkin_06441	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Actkin_06442	COG0359	binds to the 23S rRNA
Actkin_06458	COG1063	alcohol dehydrogenase
Actkin_06460	COG0583	DNA-binding transcription factor activity
Actkin_06463	COG2409	Drug exporters of the RND superfamily
Actkin_06464	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Actkin_06466	COG0495	leucyl-tRNA aminoacylation
Actkin_06468	COG1678	Uncharacterized ACR, COG1678
Actkin_06470	COG0617	tRNA 3'-terminal CCA addition
Actkin_06475	COG1595	DNA-templated transcription, initiation
Actkin_06478	COG0492	ferredoxin-NADP+ reductase activity
Actkin_06478	COG3118	belongs to the thioredoxin family
Actkin_06479	COG0860	N-Acetylmuramoyl-L-alanine amidase
Actkin_06479	COG3409	Peptidoglycan-binding domain 1 protein
Actkin_06481	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Actkin_06482	COG1181	Belongs to the D-alanine--D-alanine ligase family
Actkin_06485	COG1192	Involved in chromosome partitioning
Actkin_06486	COG0357	Ribosomal RNA small subunit methyltransferase G
Actkin_06488	COG0706	membrane insertase activity
Actkin_06489	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Actkin_06490	COG0594	ribonuclease P activity
Actkin_06491	COG0230	Belongs to the bacterial ribosomal protein bL34 family