locus-tag	class	description
LUW74_00010	COG0366	Alpha amylase catalytic
LUW74_00015	COG0366	Alpha amylase catalytic
LUW74_00020	COG0058	SHG alpha-glucan phosphorylase activity
LUW74_00030	COG1476	TRANSCRIPTIONal
LUW74_00035	COG4585	Histidine kinase
LUW74_00040	COG4279	zinc finger
LUW74_00045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LUW74_00065	COG4221	oxidoreductase activity
LUW74_00100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LUW74_00145	COG0482	sulfurtransferase activity
LUW74_00160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LUW74_00175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LUW74_00185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LUW74_00190	COG2133	pyrroloquinoline quinone binding
LUW74_00195	COG5001	Diguanylate cyclase
LUW74_00210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LUW74_00235	COG1136	(ABC) transporter
LUW74_00235	COG0577	efflux transmembrane transporter activity
LUW74_00260	COG0473	3-isopropylmalate dehydrogenase activity
LUW74_00265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LUW74_00270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW74_00305	COG2188	Transcriptional regulator
LUW74_00325	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_00355	COG2409	Drug exporters of the RND superfamily
LUW74_00375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW74_00385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LUW74_00400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW74_00410	COG1007	ATP synthesis coupled electron transport
LUW74_00435	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LUW74_00455	COG2149	membrane
LUW74_00460	COG0789	Transcriptional regulator
LUW74_00470	COG1414	Transcriptional regulator
LUW74_00475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LUW74_00480	COG0066	3-isopropylmalate dehydratase activity
LUW74_00490	COG0776	regulation of translation
LUW74_00510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LUW74_00515	COG1181	Belongs to the D-alanine--D-alanine ligase family
LUW74_00555	COG1309	transcriptional regulator
LUW74_00590	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_00610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_00615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_00620	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_00675	COG0351	phosphomethylpyrimidine kinase
LUW74_00680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LUW74_00685	COG1461	Dihydroxyacetone kinase
LUW74_00715	COG0742	ribosomal rna small subunit methyltransferase
LUW74_00720	COG0768	penicillin binding
LUW74_00725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LUW74_00735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LUW74_00745	COG0571	ribonuclease III activity
LUW74_00750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LUW74_00755	COG1254	Belongs to the acylphosphatase family
LUW74_00765	COG1196	nuclear chromosome segregation
LUW74_00780	COG3599	regulation of cell shape
LUW74_00800	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LUW74_00810	COG0228	four-way junction DNA binding
LUW74_00815	COG1837	Belongs to the UPF0109 family
LUW74_00820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LUW74_00835	COG0335	large ribosomal subunit rRNA binding
LUW74_00840	COG0681	Belongs to the peptidase S26 family
LUW74_00845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LUW74_00865	COG0792	nuclease activity
LUW74_00870	COG4974	Belongs to the 'phage' integrase family
LUW74_00880	COG0052	Belongs to the universal ribosomal protein uS2 family
LUW74_00885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LUW74_00890	COG0528	UMP kinase activity
LUW74_00895	COG0233	cytoplasmic translational termination
LUW74_00900	COG0575	Belongs to the CDS family
LUW74_00910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LUW74_00925	COG1595	DNA-templated transcription, initiation
LUW74_00950	COG0494	nUDIX hydrolase
LUW74_00960	COG1522	sequence-specific DNA binding
LUW74_00965	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_00970	COG3842	ATPase activity
LUW74_00980	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW74_00985	COG1177	transmembrane transport
LUW74_01010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_01030	COG0631	protein serine/threonine phosphatase activity
LUW74_01035	COG0515	serine threonine protein kinase
LUW74_01055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW74_01065	COG0596	Alpha beta hydrolase
LUW74_01075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW74_01100	COG2205	protein histidine kinase activity
LUW74_01115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LUW74_01125	COG0596	Alpha beta hydrolase
LUW74_01190	COG0477	Major facilitator Superfamily
LUW74_01200	COG0745	RESPONSE REGULATOR receiver
LUW74_01205	COG2205	protein histidine kinase activity
LUW74_01210	COG3979	chitinase
LUW74_01220	COG0477	Major facilitator Superfamily
LUW74_01240	COG3851	Histidine kinase
LUW74_01250	COG1309	transcriptional regulator
LUW74_01275	COG1515	deoxyribonuclease V activity
LUW74_01285	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LUW74_01285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LUW74_01345	COG4213	ABC transporter substrate-binding protein
LUW74_01355	COG4214	carbohydrate transport
LUW74_01360	COG4214	carbohydrate transport
LUW74_01370	COG1940	carbohydrate kinase activity
LUW74_01415	COG0779	Required for maturation of 30S ribosomal subunits
LUW74_01430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LUW74_01440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LUW74_01445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LUW74_01450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LUW74_01465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LUW74_01470	COG1185	polyribonucleotide nucleotidyltransferase activity
LUW74_01475	COG0612	Peptidase, M16
LUW74_01480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LUW74_01485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LUW74_01500	COG1595	DNA-templated transcription, initiation
LUW74_01505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LUW74_01530	COG0477	Major facilitator Superfamily
LUW74_01585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LUW74_01600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LUW74_01630	COG1058	Belongs to the CinA family
LUW74_01630	COG1546	Belongs to the CinA family
LUW74_01635	COG1396	sequence-specific DNA binding
LUW74_01640	COG0783	Belongs to the Dps family
LUW74_01655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LUW74_01670	COG0395	ABC-type sugar transport system, permease component
LUW74_01675	COG1175	transmembrane transport
LUW74_01705	COG1309	transcriptional regulator
LUW74_01720	COG0657	acetylesterase activity
LUW74_01730	COG0754	glutathionylspermidine amidase activity
LUW74_01745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LUW74_01750	COG2137	regulation of response to DNA damage stimulus
LUW74_01760	COG0584	glycerophosphoryl diester phosphodiesterase
LUW74_01765	COG1073	alpha beta
LUW74_01770	COG0765	amino acid transport
LUW74_01775	COG0765	amino acid transport
LUW74_01780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_01785	COG1126	abc transporter atp-binding protein
LUW74_01790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LUW74_01805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LUW74_01810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LUW74_01820	COG1309	transcriptional regulator
LUW74_01855	COG0247	lactate metabolic process
LUW74_01860	COG0277	FAD linked oxidase domain protein
LUW74_01865	COG0277	FAD linked oxidase domain protein
LUW74_01870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LUW74_01880	COG1228	amidohydrolase
LUW74_01885	COG1307	EDD domain protein, DegV family
LUW74_01910	COG1307	EDD domain protein, DegV family
LUW74_01915	COG1307	EDD domain protein, DegV family
LUW74_01940	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LUW74_01945	COG0268	Binds directly to 16S ribosomal RNA
LUW74_01950	COG0481	GTPase activity
LUW74_01985	COG1420	regulation of RNA biosynthetic process
LUW74_01990	COG0484	heat shock protein binding
LUW74_02010	COG0537	adenosine 5'-monophosphoramidase activity
LUW74_02020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LUW74_02035	COG2409	Drug exporters of the RND superfamily
LUW74_02040	COG3629	intracellular signal transduction
LUW74_02040	COG3903	Transcriptional regulator
LUW74_02045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LUW74_02060	COG1834	amidinotransferase
LUW74_02065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW74_02080	COG1175	transmembrane transport
LUW74_02090	COG0366	Alpha amylase catalytic
LUW74_02100	COG0789	Transcriptional regulator
LUW74_02125	COG1381	Involved in DNA repair and RecF pathway recombination
LUW74_02130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LUW74_02135	COG1764	response to oxidative stress
LUW74_02150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LUW74_02155	COG1121	(ABC) transporter
LUW74_02185	COG0423	glycine-tRNA ligase activity
LUW74_02200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW74_02200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW74_02210	COG3387	PFAM Glycoside hydrolase 15-related
LUW74_02230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LUW74_02240	COG2223	nitrite transmembrane transporter activity
LUW74_02250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_02255	COG0789	Transcriptional regulator
LUW74_02285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW74_02290	COG0358	DNA primase activity
LUW74_02295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW74_02300	COG0393	Putative heavy-metal-binding
LUW74_02310	COG2837	iron assimilation
LUW74_02355	COG1358	cellular component organization or biogenesis
LUW74_02365	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LUW74_02410	COG2111	Na H antiporter
LUW74_02410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW74_02415	COG2111	Na H antiporter
LUW74_02415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW74_02420	COG1006	Multisubunit Na H antiporter MnhC subunit
LUW74_02425	COG0651	ATP synthesis coupled electron transport
LUW74_02430	COG1863	multisubunit Na H antiporter MnhE subunit
LUW74_02435	COG2212	antiporter activity
LUW74_02440	COG1320	monovalent cation:proton antiporter activity
LUW74_02450	COG4585	Histidine kinase
LUW74_02470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW74_02475	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW74_02480	COG1120	ATPase activity
LUW74_02510	COG0559	Belongs to the binding-protein-dependent transport system permease family
LUW74_02535	COG1024	Enoyl-CoA hydratase
LUW74_02550	COG0477	Major facilitator Superfamily
LUW74_02580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LUW74_02600	COG0531	amino acid
LUW74_02605	COG0405	Gamma-glutamyltransferase
LUW74_02620	COG0477	Major facilitator Superfamily
LUW74_02630	COG1937	Protein conserved in bacteria
LUW74_02635	COG0406	alpha-ribazole phosphatase activity
LUW74_02640	COG0686	Belongs to the AlaDH PNT family
LUW74_02650	COG1929	Belongs to the glycerate kinase type-1 family
LUW74_02655	COG2252	PERMEase
LUW74_02695	COG4585	Histidine kinase
LUW74_02700	COG2197	response regulator
LUW74_02725	COG0745	RESPONSE REGULATOR receiver
LUW74_02735	COG2205	protein histidine kinase activity
LUW74_02745	COG1733	regulation of RNA biosynthetic process
LUW74_02800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LUW74_02805	COG0477	Major facilitator Superfamily
LUW74_02810	COG1309	transcriptional regulator
LUW74_02820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LUW74_02820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW74_02835	COG2124	cytochrome p450
LUW74_02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_02845	COG0765	amino acid transport
LUW74_02850	COG1126	abc transporter atp-binding protein
LUW74_02855	COG0174	glutamine synthetase
LUW74_02860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LUW74_02905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LUW74_02915	COG0321	lipoyl(octanoyl) transferase activity
LUW74_02920	COG3340	Belongs to the peptidase S51 family
LUW74_02925	COG1090	epimerase
LUW74_02935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LUW74_02940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LUW74_02945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LUW74_02965	COG0667	Aldo Keto reductase
LUW74_02995	COG0501	Belongs to the peptidase M48B family
LUW74_03005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LUW74_03015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW74_03020	COG0425	Belongs to the sulfur carrier protein TusA family
LUW74_03030	COG1104	cysteine desulfurase activity
LUW74_03035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LUW74_03050	COG1376	ErfK ybiS ycfS ynhG family protein
LUW74_03055	COG0501	Belongs to the peptidase M48B family
LUW74_03070	COG0791	NLP P60 protein
LUW74_03070	COG1388	LysM domain
LUW74_03070	COG3103	Sh3 type 3 domain protein
LUW74_03105	COG3842	ATPase activity
LUW74_03110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LUW74_03115	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW74_03120	COG1177	transmembrane transport
LUW74_03125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LUW74_03135	COG1845	cytochrome c oxidase, subunit III
LUW74_03140	COG2010	Cytochrome c
LUW74_03145	COG0723	plastoquinol--plastocyanin reductase activity
LUW74_03150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW74_03155	COG0438	transferase activity, transferring glycosyl groups
LUW74_03200	COG1022	Amp-dependent synthetase and ligase
LUW74_03225	COG1940	carbohydrate kinase activity
LUW74_03250	COG2197	response regulator
LUW74_03260	COG3220	belongs to the UPF0276 family
LUW74_03275	COG0301	tRNA thio-modification
LUW74_03285	COG0697	spore germination
LUW74_03290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LUW74_03295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LUW74_03310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LUW74_03315	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LUW74_03320	COG0515	serine threonine protein kinase
LUW74_03320	COG2815	serine threonine protein kinase
LUW74_03330	COG0697	spore germination
LUW74_03335	COG2022	thiamine diphosphate biosynthetic process
LUW74_03360	COG0352	thiamine-phosphate diphosphorylase activity
LUW74_03370	COG0515	serine threonine protein kinase
LUW74_03375	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW74_03385	COG0142	geranyltranstransferase activity
LUW74_03430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_03435	COG2814	Major facilitator Superfamily
LUW74_03445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LUW74_03450	COG0540	Belongs to the ATCase OTCase family
LUW74_03455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LUW74_03460	COG0505	Belongs to the CarA family
LUW74_03465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LUW74_03470	COG0543	2 iron, 2 sulfur cluster binding
LUW74_03480	COG0284	orotidine-5'-phosphate decarboxylase activity
LUW74_03490	COG0194	GDP metabolic process
LUW74_03495	COG1758	RNA polymerase activity
LUW74_03505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LUW74_03525	COG0242	peptide deformylase activity
LUW74_03530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LUW74_03540	COG0671	phosphoesterase, PA-phosphatase related
LUW74_03545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LUW74_03550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LUW74_03565	COG3201	nicotinamide mononucleotide transporter
LUW74_03570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW74_03570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW74_03575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LUW74_03580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LUW74_03605	COG3608	succinylglutamate desuccinylase aspartoacylase
LUW74_03605	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LUW74_03610	COG0746	molybdenum cofactor guanylyltransferase activity
LUW74_03640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LUW74_03645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LUW74_03660	COG2233	PERMEase
LUW74_03680	COG0726	polysaccharide deacetylase
LUW74_03755	COG0655	NAD(P)H dehydrogenase (quinone) activity
LUW74_03775	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_03785	COG1309	transcriptional regulator
LUW74_03795	COG1131	(ABC) transporter
LUW74_03805	COG4585	Histidine kinase
LUW74_03810	COG2197	response regulator
LUW74_03820	COG0549	Belongs to the carbamate kinase family
LUW74_03845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LUW74_03850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LUW74_03855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LUW74_03860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LUW74_03865	COG1309	transcriptional regulator
LUW74_03880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_03895	COG0006	proline dipeptidase activity
LUW74_03905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LUW74_03915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LUW74_03935	COG0714	Associated with various cellular activities
LUW74_03940	COG2001	Belongs to the MraZ family
LUW74_03945	COG0275	rRNA processing
LUW74_03955	COG0768	penicillin binding
LUW74_03960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LUW74_03965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LUW74_03975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LUW74_03985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LUW74_03990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LUW74_04000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LUW74_04005	COG1496	oxidoreductase activity
LUW74_04015	COG1799	cell septum assembly
LUW74_04025	COG3599	regulation of cell shape
LUW74_04050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LUW74_04085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LUW74_04090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LUW74_04095	COG0384	phenazine biosynthesis protein PhzF
LUW74_04100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LUW74_04105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW74_04110	COG0131	Imidazoleglycerol-phosphate dehydratase
LUW74_04120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LUW74_04125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LUW74_04130	COG0107	imidazoleglycerol-phosphate synthase activity
LUW74_04145	COG1960	acyl-CoA dehydrogenase activity
LUW74_04150	COG1960	acyl-CoA dehydrogenase activity
LUW74_04185	COG1132	(ABC) transporter
LUW74_04200	COG1278	Cold shock
LUW74_04210	COG0745	RESPONSE REGULATOR receiver
LUW74_04220	COG0134	indole-3-glycerol-phosphate synthase activity
LUW74_04225	COG0133	tryptophan synthase activity
LUW74_04230	COG0159	tryptophan synthase activity
LUW74_04275	COG0070	glutamate synthase
LUW74_04275	COG0069	glutamate synthase activity
LUW74_04275	COG0067	glutamate synthase
LUW74_04310	COG0047	phosphoribosylformylglycinamidine synthase activity
LUW74_04365	COG2050	protein possibly involved in aromatic compounds catabolism
LUW74_04395	COG0237	dephospho-CoA kinase activity
LUW74_04425	COG0483	inositol monophosphate 1-phosphatase activity
LUW74_04440	COG4585	Histidine kinase
LUW74_04445	COG0556	nucleotide-excision repair
LUW74_04475	COG2755	lipolytic protein G-D-S-L family
LUW74_04495	COG2813	Specifically methylates the guanine in position
LUW74_04535	COG2319	Wd-40 repeat
LUW74_04535	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW74_04570	COG0667	Aldo Keto reductase
LUW74_04580	COG2070	2-Nitropropane dioxygenase
LUW74_04605	COG1126	abc transporter atp-binding protein
LUW74_04610	COG0765	amino acid transport
LUW74_04615	COG0765	amino acid transport
LUW74_04625	COG5285	phytanoyl-CoA dioxygenase
LUW74_04635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW74_04640	COG0456	acetyltransferase
LUW74_04655	COG0504	CTP synthase activity
LUW74_04660	COG0494	nUDIX hydrolase
LUW74_04685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LUW74_04705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LUW74_04710	COG1160	GTP binding
LUW74_04750	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LUW74_04775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LUW74_04795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW74_04815	COG0277	FAD linked oxidase domain protein
LUW74_04820	COG0542	response to heat
LUW74_04830	COG1253	flavin adenine dinucleotide binding
LUW74_04840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW74_04925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW74_04930	COG0583	DNA-binding transcription factor activity
LUW74_04960	COG1357	PFAM Pentapeptide repeats (8 copies)
LUW74_04970	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW74_05015	COG0745	RESPONSE REGULATOR receiver
LUW74_05030	COG0640	Transcriptional regulator
LUW74_05060	COG0586	Pfam SNARE associated Golgi protein
LUW74_05070	COG2197	response regulator
LUW74_05075	COG1063	alcohol dehydrogenase
LUW74_05115	COG2259	Doxx family
LUW74_05140	COG0477	Major facilitator Superfamily
LUW74_05170	COG2318	DinB family
LUW74_05215	COG1846	Transcriptional regulator
LUW74_05220	COG0446	pyridine nucleotide-disulphide oxidoreductase
LUW74_05225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_05240	COG1595	DNA-templated transcription, initiation
LUW74_05265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LUW74_05285	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_05300	COG1120	ATPase activity
LUW74_05305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW74_05340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW74_05420	COG0776	regulation of translation
LUW74_05470	COG0535	radical SAM domain protein
LUW74_05515	COG2205	protein histidine kinase activity
LUW74_05545	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_05555	COG1595	DNA-templated transcription, initiation
LUW74_05585	COG2205	protein histidine kinase activity
LUW74_05590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_05610	COG0183	Belongs to the thiolase family
LUW74_05615	COG0583	DNA-binding transcription factor activity
LUW74_05630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW74_05655	COG2188	Transcriptional regulator
LUW74_05675	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LUW74_05680	COG0626	cystathionine gamma-synthase activity
LUW74_05690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LUW74_05695	COG2318	DinB family
LUW74_05720	COG0395	ABC-type sugar transport system, permease component
LUW74_05770	COG1879	ABC-type sugar transport system periplasmic component
LUW74_05775	COG1129	ABC transporter
LUW74_05780	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_05785	COG1063	alcohol dehydrogenase
LUW74_05795	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_05800	COG4948	Mandelate Racemase Muconate Lactonizing
LUW74_05805	COG0800	Aldolase
LUW74_05865	COG0154	amidase activity
LUW74_05895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LUW74_05925	COG0583	DNA-binding transcription factor activity
LUW74_05930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LUW74_05950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_05970	COG0730	response to heat
LUW74_05975	COG0583	DNA-binding transcription factor activity
LUW74_05990	COG1053	succinate dehydrogenase
LUW74_05990	COG3976	FMN-binding domain protein
LUW74_05995	COG0129	dihydroxy-acid dehydratase activity
LUW74_06000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_06015	COG1414	Transcriptional regulator
LUW74_06035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW74_06045	COG1024	Enoyl-CoA hydratase
LUW74_06050	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_06090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_06100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_06105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_06125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_06150	COG1132	(ABC) transporter
LUW74_06180	COG3424	synthase
LUW74_06185	COG1024	Enoyl-CoA hydratase
LUW74_06190	COG1024	Enoyl-CoA hydratase
LUW74_06205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_06215	COG0475	glutathione-regulated potassium exporter activity
LUW74_06220	COG2211	Major facilitator Superfamily
LUW74_06230	COG1278	Cold shock
LUW74_06245	COG0604	alcohol dehydrogenase
LUW74_06250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LUW74_06255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LUW74_06270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LUW74_06275	COG1802	Transcriptional regulator
LUW74_06290	COG0154	amidase activity
LUW74_06325	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_06340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LUW74_06380	COG4585	Histidine kinase
LUW74_06415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW74_06420	COG1120	ATPase activity
LUW74_06430	COG2226	methyltransferase
LUW74_06455	COG1309	transcriptional regulator
LUW74_06460	COG1309	transcriptional regulator
LUW74_06465	COG1131	(ABC) transporter
LUW74_06470	COG3559	Exporter of polyketide antibiotics
LUW74_06485	COG1024	Enoyl-CoA hydratase
LUW74_06495	COG1024	Enoyl-CoA hydratase
LUW74_06500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW74_06510	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_06515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LUW74_06520	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW74_06525	COG1177	transmembrane transport
LUW74_06530	COG3842	ATPase activity
LUW74_06540	COG0596	Alpha beta hydrolase
LUW74_06545	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LUW74_06550	COG0686	Belongs to the AlaDH PNT family
LUW74_06560	COG3693	PFAM glycoside hydrolase, family 10
LUW74_06570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LUW74_06575	COG2072	flavoprotein involved in K transport
LUW74_06585	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_06590	COG1129	ABC transporter
LUW74_06595	COG1879	ABC-type sugar transport system periplasmic component
LUW74_06615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LUW74_06640	COG0617	tRNA 3'-terminal CCA addition
LUW74_06640	COG0517	IMP dehydrogenase activity
LUW74_06640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LUW74_06670	COG0589	response to stress
LUW74_06715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LUW74_06735	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_06740	COG2072	flavoprotein involved in K transport
LUW74_06755	COG0633	Ferredoxin
LUW74_06760	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_06775	COG1414	Transcriptional regulator
LUW74_06800	COG0183	Belongs to the thiolase family
LUW74_06845	COG3618	amidohydrolase
LUW74_06850	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_06875	COG3250	beta-galactosidase activity
LUW74_06890	COG1175	transmembrane transport
LUW74_06930	COG1960	acyl-CoA dehydrogenase activity
LUW74_06935	COG1960	acyl-CoA dehydrogenase activity
LUW74_06945	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_06970	COG1960	acyl-CoA dehydrogenase activity
LUW74_06975	COG1960	acyl-CoA dehydrogenase activity
LUW74_07025	COG1595	DNA-templated transcription, initiation
LUW74_07055	COG2267	carboxylic ester hydrolase activity
LUW74_07060	COG1129	ABC transporter
LUW74_07070	COG1879	ABC-type sugar transport system periplasmic component
LUW74_07090	COG3384	dioxygenase
LUW74_07100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_07125	COG0596	Alpha beta hydrolase
LUW74_07170	COG3795	YCII-related domain
LUW74_07175	COG4941	Belongs to the sigma-70 factor family
LUW74_07210	COG2267	carboxylic ester hydrolase activity
LUW74_07235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_07255	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_07265	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_07280	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_07305	COG1802	Transcriptional regulator
LUW74_07310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_07310	COG1116	anion transmembrane transporter activity
LUW74_07320	COG1174	glycine betaine transport
LUW74_07325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_07345	COG1802	Transcriptional regulator
LUW74_07400	COG1802	Transcriptional regulator
LUW74_07405	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_07420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_07430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW74_07450	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
LUW74_07455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_07460	COG1024	Enoyl-CoA hydratase
LUW74_07480	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW74_07490	COG2267	carboxylic ester hydrolase activity
LUW74_07510	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_07545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_07545	COG2226	methyltransferase
LUW74_07545	COG3433	isochorismatase activity
LUW74_07560	COG4166	transmembrane transport
LUW74_07570	COG1126	abc transporter atp-binding protein
LUW74_07585	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_07585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW74_07585	COG3321	synthase
LUW74_07585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LUW74_07585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_07590	COG3634	alkyl hydroperoxide reductase activity
LUW74_07610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_07615	COG3433	isochorismatase activity
LUW74_07615	COG2226	methyltransferase
LUW74_07615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_07620	COG4106	trans-aconitate 2-methyltransferase activity
LUW74_07630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LUW74_07635	COG0436	Aminotransferase
LUW74_07650	COG0596	Alpha beta hydrolase
LUW74_07660	COG0405	Gamma-glutamyltransferase
LUW74_07665	COG3619	membrane
LUW74_07730	COG2181	nitrate reductase activity
LUW74_07730	COG0247	lactate metabolic process
LUW74_07735	COG0277	FAD linked oxidase domain protein
LUW74_07750	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_07760	COG3631	Ketosteroid isomerase-related protein
LUW74_07770	COG1960	acyl-CoA dehydrogenase activity
LUW74_07775	COG1960	acyl-CoA dehydrogenase activity
LUW74_07780	COG1960	acyl-CoA dehydrogenase activity
LUW74_07790	COG1984	allophanate hydrolase subunit 2
LUW74_07800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LUW74_07805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LUW74_07815	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_07835	COG1073	alpha beta
LUW74_07840	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_07845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_07850	COG0183	Belongs to the thiolase family
LUW74_07855	COG0583	DNA-binding transcription factor activity
LUW74_07875	COG2376	Dihydroxyacetone kinase
LUW74_07890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LUW74_07920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW74_07940	COG0243	molybdopterin cofactor binding
LUW74_07945	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW74_07950	COG1191	sigma factor activity
LUW74_07955	COG0248	Ppx GppA phosphatase
LUW74_07960	COG0723	plastoquinol--plastocyanin reductase activity
LUW74_07960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LUW74_07985	COG0154	amidase activity
LUW74_08005	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW74_08010	COG0022	dehydrogenase e1 component
LUW74_08025	COG1063	alcohol dehydrogenase
LUW74_08040	COG1414	Transcriptional regulator
LUW74_08095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW74_08120	COG1999	signal sequence binding
LUW74_08140	COG2197	response regulator
LUW74_08150	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW74_08180	COG0604	alcohol dehydrogenase
LUW74_08180	COG3321	synthase
LUW74_08190	COG3321	synthase
LUW74_08190	COG0604	alcohol dehydrogenase
LUW74_08200	COG3321	synthase
LUW74_08200	COG0604	alcohol dehydrogenase
LUW74_08210	COG0604	alcohol dehydrogenase
LUW74_08210	COG3321	synthase
LUW74_08245	COG3321	synthase
LUW74_08245	COG0604	alcohol dehydrogenase
LUW74_08265	COG3903	Transcriptional regulator
LUW74_08265	COG3629	intracellular signal transduction
LUW74_08310	COG0667	Aldo Keto reductase
LUW74_08410	COG1960	acyl-CoA dehydrogenase activity
LUW74_08420	COG1309	transcriptional regulator
LUW74_08425	COG0183	Belongs to the thiolase family
LUW74_08435	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LUW74_08440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LUW74_08445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LUW74_08455	COG1414	Transcriptional regulator
LUW74_08460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LUW74_08480	COG1024	Enoyl-CoA hydratase
LUW74_08485	COG1960	acyl-CoA dehydrogenase activity
LUW74_08500	COG0667	Aldo Keto reductase
LUW74_08530	COG1024	Enoyl-CoA hydratase
LUW74_08535	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_08540	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_08545	COG0515	serine threonine protein kinase
LUW74_08550	COG1643	Atp-dependent helicase
LUW74_08585	COG1119	ATPase activity
LUW74_08595	COG2409	Drug exporters of the RND superfamily
LUW74_08630	COG2084	Dehydrogenase
LUW74_08645	COG2050	protein possibly involved in aromatic compounds catabolism
LUW74_08670	COG1131	(ABC) transporter
LUW74_08675	COG4585	Histidine kinase
LUW74_08680	COG2197	response regulator
LUW74_08690	COG1309	transcriptional regulator
LUW74_08825	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_08840	COG1129	ABC transporter
LUW74_08845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_08895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW74_08900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LUW74_08925	COG0494	nUDIX hydrolase
LUW74_08940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LUW74_08955	COG4999	Histidine kinase
LUW74_08955	COG3850	Histidine kinase
LUW74_08955	COG3437	response regulator, receiver
LUW74_08955	COG2205	protein histidine kinase activity
LUW74_08975	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LUW74_08985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LUW74_09020	COG2814	Major facilitator Superfamily
LUW74_09045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LUW74_09055	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_09060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_09085	COG2124	cytochrome p450
LUW74_09120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW74_09125	COG4166	transmembrane transport
LUW74_09130	COG0601	transmembrane transport
LUW74_09135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW74_09145	COG4608	Belongs to the ABC transporter superfamily
LUW74_09155	COG0702	epimerase
LUW74_09180	COG2205	protein histidine kinase activity
LUW74_09190	COG2172	sigma factor antagonist activity
LUW74_09195	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW74_09200	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW74_09215	COG1136	(ABC) transporter
LUW74_09215	COG0577	efflux transmembrane transporter activity
LUW74_09250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW74_09270	COG2366	antibiotic biosynthetic process
LUW74_09280	COG0488	(ABC) transporter
LUW74_09290	COG0583	DNA-binding transcription factor activity
LUW74_09315	COG1917	Cupin 2, conserved barrel domain protein
LUW74_09325	COG3844	kynureninase activity
LUW74_09330	COG1278	Cold shock
LUW74_09365	COG2197	response regulator
LUW74_09375	COG4585	Histidine kinase
LUW74_09390	COG0477	Major facilitator Superfamily
LUW74_09395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LUW74_09435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LUW74_09440	COG1560	Kdo2-lipid A biosynthetic process
LUW74_09445	COG0438	transferase activity, transferring glycosyl groups
LUW74_09460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LUW74_09470	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LUW74_09475	COG0217	transcriptional regulatory protein
LUW74_09490	COG0632	four-way junction helicase activity
LUW74_09495	COG2255	four-way junction helicase activity
LUW74_09510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW74_09515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW74_09520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LUW74_09525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LUW74_09535	COG0124	histidyl-tRNA synthetase
LUW74_09540	COG0124	histidyl-tRNA synthetase
LUW74_09555	COG1196	nuclear chromosome segregation
LUW74_09605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LUW74_09610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LUW74_09625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW74_09635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LUW74_09645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LUW74_09650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LUW74_09660	COG5002	protein histidine kinase activity
LUW74_09665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LUW74_09685	COG0488	(ABC) transporter
LUW74_09710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LUW74_09720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LUW74_09730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LUW74_09735	COG1438	arginine binding
LUW74_09740	COG0165	Argininosuccinate lyase
LUW74_09745	COG2094	Belongs to the DNA glycosylase MPG family
LUW74_09755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LUW74_09810	COG1309	transcriptional regulator
LUW74_09870	COG1522	sequence-specific DNA binding
LUW74_09890	COG0477	Major facilitator Superfamily
LUW74_09905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LUW74_09920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW74_09925	COG0583	DNA-binding transcription factor activity
LUW74_09935	COG1376	ErfK ybiS ycfS ynhG family protein
LUW74_09940	COG1376	ErfK ybiS ycfS ynhG family protein
LUW74_09945	COG0438	transferase activity, transferring glycosyl groups
LUW74_09950	COG2205	protein histidine kinase activity
LUW74_09955	COG2205	protein histidine kinase activity
LUW74_09960	COG0745	RESPONSE REGULATOR receiver
LUW74_09975	COG1136	(ABC) transporter
LUW74_09980	COG0577	efflux transmembrane transporter activity
LUW74_09990	COG1070	Carbohydrate kinase
LUW74_10030	COG0395	ABC-type sugar transport system, permease component
LUW74_10045	COG2851	Citrate transporter
LUW74_10060	COG5297	Belongs to the glycosyl hydrolase family 6
LUW74_10075	COG4733	cellulase activity
LUW74_10075	COG5297	Belongs to the glycosyl hydrolase family 6
LUW74_10090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LUW74_10165	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_10185	COG3559	Exporter of polyketide antibiotics
LUW74_10190	COG1131	(ABC) transporter
LUW74_10195	COG1309	transcriptional regulator
LUW74_10200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW74_10205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW74_10220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LUW74_10225	COG1021	2,3-dihydroxybenzoate-AMP ligase
LUW74_10315	COG1169	isochorismate synthase
LUW74_10325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_10325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_10335	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LUW74_10365	COG1309	transcriptional regulator
LUW74_10385	COG0559	Belongs to the binding-protein-dependent transport system permease family
LUW74_10395	COG1349	DNA-binding transcription factor activity
LUW74_10400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW74_10415	COG2213	PTS system mannitol-specific
LUW74_10415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW74_10435	COG0697	spore germination
LUW74_10485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW74_10500	COG1960	acyl-CoA dehydrogenase activity
LUW74_10540	COG0673	inositol 2-dehydrogenase activity
LUW74_10585	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_10610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_10615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_10625	COG3290	protein histidine kinase activity
LUW74_10630	COG4565	transcriptional regulatory protein
LUW74_10635	COG1131	(ABC) transporter
LUW74_10665	COG1215	transferase activity, transferring glycosyl groups
LUW74_10670	COG1960	acyl-CoA dehydrogenase activity
LUW74_10680	COG4585	Histidine kinase
LUW74_10685	COG2197	response regulator
LUW74_10690	COG1309	transcriptional regulator
LUW74_10695	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_10700	COG2272	Belongs to the type-B carboxylesterase lipase family
LUW74_10710	COG2197	response regulator
LUW74_10730	COG1609	Transcriptional regulator
LUW74_10755	COG0395	ABC-type sugar transport system, permease component
LUW74_10760	COG0252	asparaginase activity
LUW74_10780	COG1902	pentaerythritol trinitrate reductase activity
LUW74_10785	COG3665	Urea carboxylase-associated protein
LUW74_10790	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_10795	COG1595	DNA-templated transcription, initiation
LUW74_10810	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW74_10835	COG1309	transcriptional regulator
LUW74_10845	COG1309	transcriptional regulator
LUW74_10850	COG4608	Belongs to the ABC transporter superfamily
LUW74_10855	COG0444	Belongs to the ABC transporter superfamily
LUW74_10865	COG0601	transmembrane transport
LUW74_10905	COG0346	lactoylglutathione lyase activity
LUW74_10925	COG2378	regulation of single-species biofilm formation
LUW74_10930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LUW74_10950	COG0243	molybdopterin cofactor binding
LUW74_10965	COG2050	protein possibly involved in aromatic compounds catabolism
LUW74_10980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LUW74_10985	COG0657	acetylesterase activity
LUW74_10995	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_11000	COG0477	Major facilitator Superfamily
LUW74_11015	COG1690	Belongs to the RtcB family
LUW74_11025	COG1940	carbohydrate kinase activity
LUW74_11030	COG1653	transport
LUW74_11035	COG1175	transmembrane transport
LUW74_11040	COG0395	ABC-type sugar transport system, permease component
LUW74_11045	COG2723	6-phospho-beta-galactosidase activity
LUW74_11055	COG1137	ATPase activity
LUW74_11065	COG3973	AAA domain
LUW74_11085	COG1960	acyl-CoA dehydrogenase activity
LUW74_11090	COG1960	acyl-CoA dehydrogenase activity
LUW74_11095	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LUW74_11100	COG0563	adenylate kinase activity
LUW74_11110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LUW74_11110	COG3608	succinylglutamate desuccinylase aspartoacylase
LUW74_11125	COG3629	intracellular signal transduction
LUW74_11125	COG3903	Transcriptional regulator
LUW74_11135	COG3485	protocatechuate 3,4-dioxygenase
LUW74_11140	COG3485	protocatechuate 3,4-dioxygenase
LUW74_11145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LUW74_11155	COG1414	Transcriptional regulator
LUW74_11170	COG0189	ligase activity
LUW74_11170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LUW74_11185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LUW74_11200	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LUW74_11235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LUW74_11240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LUW74_11260	COG0859	PFAM glycosyl transferase family 9
LUW74_11265	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_11270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LUW74_11270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LUW74_11275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LUW74_11280	COG0438	transferase activity, transferring glycosyl groups
LUW74_11305	COG2192	nodulation
LUW74_11325	COG0477	Major facilitator Superfamily
LUW74_11340	COG0667	Aldo Keto reductase
LUW74_11355	COG2030	dehydratase
LUW74_11355	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_11360	COG0583	DNA-binding transcription factor activity
LUW74_11380	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_11390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LUW74_11410	COG0683	leucine binding
LUW74_11415	COG2423	ornithine cyclodeaminase activity
LUW74_11445	COG3938	Belongs to the proline racemase family
LUW74_11470	COG0166	Belongs to the GPI family
LUW74_11485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW74_11500	COG2188	Transcriptional regulator
LUW74_11525	COG0702	epimerase
LUW74_11545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LUW74_11555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LUW74_11570	COG4585	Histidine kinase
LUW74_11580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LUW74_11585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW74_11590	COG1280	lysine exporter protein (LysE YggA)
LUW74_11600	COG3879	Bacterial protein of unknown function (DUF881)
LUW74_11665	COG0247	lactate metabolic process
LUW74_11670	COG1139	Iron-sulfur cluster binding protein
LUW74_11675	COG1556	Lactate utilization protein
LUW74_11700	COG2223	nitrite transmembrane transporter activity
LUW74_11715	COG0243	molybdopterin cofactor binding
LUW74_11755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW74_11770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LUW74_11780	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LUW74_11790	COG2365	Tyrosine phosphatase family
LUW74_11815	COG1169	isochorismate synthase
LUW74_11830	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_11840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW74_11845	COG4977	sequence-specific DNA binding
LUW74_11850	COG2249	NAD(P)H dehydrogenase (quinone) activity
LUW74_11860	COG1649	PFAM Uncharacterised BCR, COG1649
LUW74_11870	COG1733	regulation of RNA biosynthetic process
LUW74_11955	COG0085	RNA polymerase activity
LUW74_11995	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW74_12015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_12020	COG1295	ribonuclease BN
LUW74_12035	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_12050	COG0477	Major facilitator Superfamily
LUW74_12055	COG4257	antibiotic catabolic process
LUW74_12095	COG2205	protein histidine kinase activity
LUW74_12100	COG0745	RESPONSE REGULATOR receiver
LUW74_12105	COG2409	Drug exporters of the RND superfamily
LUW74_12145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW74_12150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW74_12180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LUW74_12190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LUW74_12215	COG0596	Alpha beta hydrolase
LUW74_12235	COG0583	DNA-binding transcription factor activity
LUW74_12240	COG0477	Major facilitator Superfamily
LUW74_12270	COG1278	Cold shock
LUW74_12305	COG1162	GTPase activity
LUW74_12320	COG0745	RESPONSE REGULATOR receiver
LUW74_12325	COG2205	protein histidine kinase activity
LUW74_12335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LUW74_12340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LUW74_12345	COG2154	pterin-4-alpha-carbinolamine dehydratase
LUW74_12385	COG3467	pyridoxamine 5'-phosphate
LUW74_12390	COG1309	transcriptional regulator
LUW74_12405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW74_12425	COG0583	DNA-binding transcription factor activity
LUW74_12485	COG0583	DNA-binding transcription factor activity
LUW74_12500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW74_12540	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_12555	COG1739	Uncharacterized protein family UPF0029
LUW74_12595	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW74_12605	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW74_12640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LUW74_12645	COG1595	DNA-templated transcription, initiation
LUW74_12650	COG2197	response regulator
LUW74_12655	COG4585	Histidine kinase
LUW74_12695	COG4974	Belongs to the 'phage' integrase family
LUW74_12755	COG1271	oxidase subunit
LUW74_12765	COG4988	ABC transporter
LUW74_12770	COG1132	(ABC) transporter
LUW74_12775	COG1132	(ABC) transporter
LUW74_12775	COG2375	cellular response to nickel ion
LUW74_12785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW74_12835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_12865	COG2111	Na H antiporter
LUW74_12865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW74_12885	COG2378	regulation of single-species biofilm formation
LUW74_12935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LUW74_12940	COG0657	acetylesterase activity
LUW74_12975	COG2304	oxidoreductase activity
LUW74_12995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LUW74_13000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LUW74_13030	COG0740	serine-type endopeptidase activity
LUW74_13035	COG0740	serine-type endopeptidase activity
LUW74_13050	COG4585	Histidine kinase
LUW74_13070	COG3030	protein affecting phage T7 exclusion by the F plasmid
LUW74_13075	COG1216	Glycosyl transferase, family 2
LUW74_13090	COG1607	acyl-coa hydrolase
LUW74_13095	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LUW74_13105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LUW74_13135	COG0604	alcohol dehydrogenase
LUW74_13140	COG1509	lysine 2,3-aminomutase activity
LUW74_13145	COG2124	cytochrome p450
LUW74_13155	COG1960	acyl-CoA dehydrogenase activity
LUW74_13175	COG1522	sequence-specific DNA binding
LUW74_13190	COG0395	ABC-type sugar transport system, permease component
LUW74_13195	COG1175	transmembrane transport
LUW74_13200	COG1653	transport
LUW74_13215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LUW74_13225	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LUW74_13235	COG5398	heme oxygenase
LUW74_13255	COG2146	nitrite reductase [NAD(P)H] activity
LUW74_13255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LUW74_13270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LUW74_13290	COG0247	lactate metabolic process
LUW74_13290	COG0277	FAD linked oxidase domain protein
LUW74_13300	COG0577	efflux transmembrane transporter activity
LUW74_13300	COG1136	(ABC) transporter
LUW74_13335	COG0805	protein transport
LUW74_13340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LUW74_13375	COG0544	peptidyl-prolyl cis-trans isomerase activity
LUW74_13385	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LUW74_13390	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LUW74_13440	COG2197	response regulator
LUW74_13445	COG1136	(ABC) transporter
LUW74_13445	COG0577	efflux transmembrane transporter activity
LUW74_13450	COG0577	efflux transmembrane transporter activity
LUW74_13455	COG4608	Belongs to the ABC transporter superfamily
LUW74_13460	COG0444	Belongs to the ABC transporter superfamily
LUW74_13470	COG0747	negative chemotaxis
LUW74_13475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW74_13485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LUW74_13500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LUW74_13515	COG0215	cysteine-tRNA ligase activity
LUW74_13520	COG0601	transmembrane transport
LUW74_13550	COG0598	Magnesium transport protein CorA
LUW74_13585	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_13600	COG3360	Dodecin
LUW74_13610	COG0515	serine threonine protein kinase
LUW74_13640	COG1703	isobutyryl-CoA mutase activity
LUW74_13640	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LUW74_13640	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LUW74_13645	COG1846	Transcriptional regulator
LUW74_13680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_13685	COG0477	Major facilitator Superfamily
LUW74_13700	COG0746	molybdenum cofactor guanylyltransferase activity
LUW74_13705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LUW74_13710	COG2267	carboxylic ester hydrolase activity
LUW74_13715	COG1690	Belongs to the RtcB family
LUW74_13725	COG0477	Major facilitator Superfamily
LUW74_13740	COG0709	Synthesizes selenophosphate from selenide and ATP
LUW74_13760	COG2860	membrane
LUW74_13765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LUW74_13785	COG0516	GMP reductase activity
LUW74_13785	COG0517	IMP dehydrogenase activity
LUW74_13790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW74_13795	COG2364	Membrane
LUW74_13800	COG1929	Belongs to the glycerate kinase type-1 family
LUW74_13810	COG1619	proteins homologs of microcin C7 resistance protein MccF
LUW74_13815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LUW74_13825	COG1132	(ABC) transporter
LUW74_13830	COG2936	dipeptidyl-peptidase activity
LUW74_13835	COG1024	Enoyl-CoA hydratase
LUW74_13900	COG2151	metal-sulfur cluster biosynthetic enzyme
LUW74_13905	COG0822	iron-sulfur transferase activity
LUW74_13915	COG0396	ATPase activity
LUW74_13940	COG0549	Belongs to the carbamate kinase family
LUW74_13945	COG1131	(ABC) transporter
LUW74_13965	COG1796	DNA polymerase
LUW74_13965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LUW74_13985	COG0109	protoheme IX farnesyltransferase activity
LUW74_13995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LUW74_14010	COG0166	Belongs to the GPI family
LUW74_14030	COG0363	glucosamine-6-phosphate deaminase activity
LUW74_14035	COG1376	ErfK ybiS ycfS ynhG family protein
LUW74_14065	COG0477	Major facilitator Superfamily
LUW74_14075	COG4585	Histidine kinase
LUW74_14085	COG2197	response regulator
LUW74_14090	COG0477	Major facilitator Superfamily
LUW74_14110	COG1695	Transcriptional regulator
LUW74_14120	COG4585	Histidine kinase
LUW74_14125	COG2197	response regulator
LUW74_14140	COG2409	Drug exporters of the RND superfamily
LUW74_14145	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_14170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW74_14175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LUW74_14205	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LUW74_14220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW74_14220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_14245	COG1522	sequence-specific DNA binding
LUW74_14255	COG2367	Beta-lactamase
LUW74_14265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LUW74_14270	COG0149	triose-phosphate isomerase activity
LUW74_14275	COG0126	phosphoglycerate kinase activity
LUW74_14280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LUW74_14300	COG1481	regulation of sporulation
LUW74_14305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LUW74_14310	COG1660	Displays ATPase and GTPase activities
LUW74_14315	COG0322	excinuclease ABC activity
LUW74_14335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW74_14340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW74_14355	COG3903	Transcriptional regulator
LUW74_14355	COG3629	intracellular signal transduction
LUW74_14380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW74_14400	COG2814	Major facilitator Superfamily
LUW74_14410	COG0542	response to heat
LUW74_14425	COG1960	acyl-CoA dehydrogenase activity
LUW74_14435	COG0438	transferase activity, transferring glycosyl groups
LUW74_14465	COG0497	DNA recombination
LUW74_14490	COG0647	UMP catabolic process
LUW74_14550	COG1024	Enoyl-CoA hydratase
LUW74_14580	COG0406	alpha-ribazole phosphatase activity
LUW74_14585	COG1070	Carbohydrate kinase
LUW74_14595	COG4214	carbohydrate transport
LUW74_14605	COG4213	ABC transporter substrate-binding protein
LUW74_14610	COG1349	DNA-binding transcription factor activity
LUW74_14615	COG0435	Glutathione S-transferase
LUW74_14625	COG0431	NADPH-dependent FMN reductase
LUW74_14635	COG0673	inositol 2-dehydrogenase activity
LUW74_14670	COG3903	Transcriptional regulator
LUW74_14670	COG3629	intracellular signal transduction
LUW74_14680	COG0247	lactate metabolic process
LUW74_14680	COG0277	FAD linked oxidase domain protein
LUW74_14735	COG0137	argininosuccinate synthase activity
LUW74_14740	COG1742	UPF0060 membrane protein
LUW74_14770	COG1136	(ABC) transporter
LUW74_14770	COG0577	efflux transmembrane transporter activity
LUW74_14790	COG3620	sequence-specific DNA binding
LUW74_14830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LUW74_14845	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_14890	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_14915	COG0702	epimerase
LUW74_14925	COG2124	cytochrome p450
LUW74_14945	COG0183	Belongs to the thiolase family
LUW74_14950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LUW74_14990	COG1116	anion transmembrane transporter activity
LUW74_14995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_15000	COG0427	acetyl-CoA hydrolase
LUW74_15025	COG4689	acetoacetate decarboxylase
LUW74_15050	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_15055	COG2078	PFAM AMMECR1 domain protein
LUW74_15055	COG3885	ferrous iron binding
LUW74_15065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_15070	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_15075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LUW74_15080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LUW74_15080	COG0519	Catalyzes the synthesis of GMP from XMP
LUW74_15085	COG0583	DNA-binding transcription factor activity
LUW74_15130	COG0596	Alpha beta hydrolase
LUW74_15145	COG4221	oxidoreductase activity
LUW74_15160	COG2226	methyltransferase
LUW74_15180	COG0477	Major facilitator Superfamily
LUW74_15195	COG3903	Transcriptional regulator
LUW74_15195	COG3629	intracellular signal transduction
LUW74_15215	COG0745	RESPONSE REGULATOR receiver
LUW74_15250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LUW74_15255	COG1116	anion transmembrane transporter activity
LUW74_15260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_15265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_15280	COG1131	(ABC) transporter
LUW74_15300	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_15320	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_15325	COG1024	Enoyl-CoA hydratase
LUW74_15335	COG2124	cytochrome p450
LUW74_15350	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_15355	COG2267	carboxylic ester hydrolase activity
LUW74_15375	COG2124	cytochrome p450
LUW74_15440	COG4733	cellulase activity
LUW74_15475	COG3842	ATPase activity
LUW74_15515	COG4221	oxidoreductase activity
LUW74_15525	COG0477	Major facilitator Superfamily
LUW74_15535	COG2301	Belongs to the HpcH HpaI aldolase family
LUW74_15545	COG1024	Enoyl-CoA hydratase
LUW74_15570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_15585	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_15610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_15615	COG2072	flavoprotein involved in K transport
LUW74_15620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_15630	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_15635	COG4221	oxidoreductase activity
LUW74_15640	COG1960	acyl-CoA dehydrogenase activity
LUW74_15650	COG1960	acyl-CoA dehydrogenase activity
LUW74_15655	COG0183	Belongs to the thiolase family
LUW74_15665	COG1024	Enoyl-CoA hydratase
LUW74_15670	COG2186	Transcriptional regulator
LUW74_15680	COG0444	Belongs to the ABC transporter superfamily
LUW74_15685	COG0601	transmembrane transport
LUW74_15740	COG2814	Major facilitator Superfamily
LUW74_15745	COG0583	DNA-binding transcription factor activity
LUW74_15770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_15780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_15795	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_15805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_15825	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_15860	COG1609	Transcriptional regulator
LUW74_15865	COG1960	acyl-CoA dehydrogenase activity
LUW74_15870	COG1960	acyl-CoA dehydrogenase activity
LUW74_15875	COG0183	Belongs to the thiolase family
LUW74_15895	COG1960	acyl-CoA dehydrogenase activity
LUW74_15905	COG1024	Enoyl-CoA hydratase
LUW74_15915	COG1960	acyl-CoA dehydrogenase activity
LUW74_15920	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_15925	COG0604	alcohol dehydrogenase
LUW74_15925	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_15925	COG3321	synthase
LUW74_15935	COG1024	Enoyl-CoA hydratase
LUW74_15955	COG1024	Enoyl-CoA hydratase
LUW74_15970	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW74_15975	COG1960	acyl-CoA dehydrogenase activity
LUW74_15980	COG1960	acyl-CoA dehydrogenase activity
LUW74_15990	COG1960	acyl-CoA dehydrogenase activity
LUW74_15995	COG1960	acyl-CoA dehydrogenase activity
LUW74_16005	COG1024	Enoyl-CoA hydratase
LUW74_16010	COG1024	Enoyl-CoA hydratase
LUW74_16015	COG0183	Belongs to the thiolase family
LUW74_16020	COG1024	Enoyl-CoA hydratase
LUW74_16025	COG1960	acyl-CoA dehydrogenase activity
LUW74_16035	COG1063	alcohol dehydrogenase
LUW74_16050	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_16055	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_16060	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_16120	COG2130	NADP-dependent
LUW74_16125	COG0028	Belongs to the TPP enzyme family
LUW74_16140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_16145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW74_16150	COG1024	Enoyl-CoA hydratase
LUW74_16225	COG3842	ATPase activity
LUW74_16230	COG2011	ABC-type metal ion transport system permease component
LUW74_16240	COG2182	Extracellular solute-binding protein
LUW74_16245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LUW74_16250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LUW74_16255	COG0640	Transcriptional regulator
LUW74_16275	COG3250	beta-galactosidase activity
LUW74_16295	COG0395	ABC-type sugar transport system, permease component
LUW74_16320	COG3537	Alpha-1,2-mannosidase
LUW74_16340	COG4214	carbohydrate transport
LUW74_16345	COG4213	ABC transporter substrate-binding protein
LUW74_16350	COG4213	ABC transporter substrate-binding protein
LUW74_16355	COG3629	intracellular signal transduction
LUW74_16375	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_16380	COG1129	ABC transporter
LUW74_16395	COG0434	BtpA family
LUW74_16400	COG1609	Transcriptional regulator
LUW74_16435	COG2018	Roadblock/LC7 domain
LUW74_16475	COG1396	sequence-specific DNA binding
LUW74_16480	COG0740	serine-type endopeptidase activity
LUW74_16485	COG0740	serine-type endopeptidase activity
LUW74_16500	COG0726	polysaccharide deacetylase
LUW74_16540	COG1486	melibiose metabolic process
LUW74_16555	COG2182	Extracellular solute-binding protein
LUW74_16560	COG1175	transmembrane transport
LUW74_16565	COG0395	ABC-type sugar transport system, permease component
LUW74_16575	COG1105	Belongs to the carbohydrate kinase PfkB family
LUW74_16605	COG1595	DNA-templated transcription, initiation
LUW74_16625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LUW74_16675	COG1960	acyl-CoA dehydrogenase activity
LUW74_16685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW74_16690	COG0740	serine-type endopeptidase activity
LUW74_16695	COG1414	Transcriptional regulator
LUW74_16705	COG2124	cytochrome p450
LUW74_16735	COG0437	4 iron, 4 sulfur cluster binding
LUW74_16750	COG1946	Acyl-CoA thioesterase
LUW74_16760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW74_16775	COG1280	lysine exporter protein (LysE YggA)
LUW74_16800	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_16810	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW74_16815	COG3842	ATPase activity
LUW74_16825	COG1609	Transcriptional regulator
LUW74_16845	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LUW74_16860	COG0431	NADPH-dependent FMN reductase
LUW74_16880	COG2353	YceI-like domain
LUW74_16915	COG2186	Transcriptional regulator
LUW74_16920	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_16940	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_17035	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LUW74_17100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LUW74_17105	COG1968	undecaprenyl-diphosphatase activity
LUW74_17125	COG0402	S-adenosylhomocysteine deaminase activity
LUW74_17130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_17155	COG1414	Transcriptional regulator
LUW74_17170	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_17180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW74_17215	COG1940	carbohydrate kinase activity
LUW74_17215	COG1846	Transcriptional regulator
LUW74_17225	COG1126	abc transporter atp-binding protein
LUW74_17235	COG0765	amino acid transport
LUW74_17240	COG0765	amino acid transport
LUW74_17250	COG3142	Participates in the control of copper homeostasis
LUW74_17260	COG0366	Alpha amylase catalytic
LUW74_17280	COG0366	Alpha amylase catalytic
LUW74_17285	COG3281	Trehalose synthase
LUW74_17295	COG0667	Aldo Keto reductase
LUW74_17305	COG3842	ATPase activity
LUW74_17315	COG1077	Cell shape determining protein MreB Mrl
LUW74_17335	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LUW74_17340	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LUW74_17365	COG0626	cystathionine gamma-synthase activity
LUW74_17395	COG0174	glutamine synthetase
LUW74_17420	COG0747	negative chemotaxis
LUW74_17445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LUW74_17460	COG0235	Class ii aldolase
LUW74_17460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LUW74_17475	COG0587	DNA-directed DNA polymerase activity
LUW74_17480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW74_17480	COG0515	serine threonine protein kinase
LUW74_17485	COG0823	Involved in the tonB-independent uptake of proteins
LUW74_17490	COG2409	Drug exporters of the RND superfamily
LUW74_17505	COG0248	Ppx GppA phosphatase
LUW74_17515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW74_17525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW74_17555	COG0656	L-ascorbic acid biosynthetic process
LUW74_17575	COG3250	beta-galactosidase activity
LUW74_17580	COG3250	beta-galactosidase activity
LUW74_17600	COG3250	beta-galactosidase activity
LUW74_17605	COG3250	beta-galactosidase activity
LUW74_17610	COG3250	beta-galactosidase activity
LUW74_17630	COG3347	Dehydrogenase
LUW74_17630	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_17635	COG3250	beta-galactosidase activity
LUW74_17650	COG3254	rhamnose metabolic process
LUW74_17655	COG1879	ABC-type sugar transport system periplasmic component
LUW74_17670	COG1129	ABC transporter
LUW74_17675	COG1609	Transcriptional regulator
LUW74_17680	COG0247	lactate metabolic process
LUW74_17685	COG1139	Iron-sulfur cluster binding protein
LUW74_17690	COG1556	Lactate utilization protein
LUW74_17695	COG1070	Carbohydrate kinase
LUW74_17700	COG1672	PFAM Archaeal ATPase
LUW74_17700	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW74_17765	COG1643	Atp-dependent helicase
LUW74_17795	COG3284	Transcriptional regulator
LUW74_17815	COG0183	Belongs to the thiolase family
LUW74_17855	COG2755	lipolytic protein G-D-S-L family
LUW74_17900	COG3540	Alkaline phosphatase
LUW74_18000	COG0210	DNA helicase
LUW74_18005	COG2815	serine threonine protein kinase
LUW74_18005	COG0515	serine threonine protein kinase
LUW74_18015	COG0328	RNA-DNA hybrid ribonuclease activity
LUW74_18045	COG0601	transmembrane transport
LUW74_18050	COG0444	Belongs to the ABC transporter superfamily
LUW74_18075	COG4948	Mandelate Racemase Muconate Lactonizing
LUW74_18080	COG2508	Transcriptional regulator
LUW74_18080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LUW74_18090	COG0667	Aldo Keto reductase
LUW74_18110	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LUW74_18115	COG0454	-acetyltransferase
LUW74_18125	COG2197	response regulator
LUW74_18135	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
LUW74_18145	COG0477	Major facilitator Superfamily
LUW74_18165	COG1764	response to oxidative stress
LUW74_18170	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_18170	COG0204	Acyl-transferase
LUW74_18195	COG0668	transmembrane transport
LUW74_18220	COG0438	transferase activity, transferring glycosyl groups
LUW74_18225	COG1672	PFAM Archaeal ATPase
LUW74_18225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW74_18290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_18310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_18315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_18325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LUW74_18395	COG1960	acyl-CoA dehydrogenase activity
LUW74_18435	COG0235	Class ii aldolase
LUW74_18440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW74_18445	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_18460	COG0443	Heat shock 70 kDa protein
LUW74_18495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_18500	COG1309	transcriptional regulator
LUW74_18510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW74_18525	COG1309	transcriptional regulator
LUW74_18560	COG2186	Transcriptional regulator
LUW74_18565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW74_18580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_18600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LUW74_18635	COG0714	Associated with various cellular activities
LUW74_18660	COG0714	Associated with various cellular activities
LUW74_18670	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LUW74_18685	COG0640	Transcriptional regulator
LUW74_18695	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LUW74_18710	COG1597	lipid kinase activity
LUW74_18720	COG0667	Aldo Keto reductase
LUW74_18755	COG0300	oxidoreductase activity
LUW74_18770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LUW74_18775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LUW74_18790	COG4948	Mandelate Racemase Muconate Lactonizing
LUW74_18795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LUW74_18805	COG1175	transmembrane transport
LUW74_18810	COG0395	ABC-type sugar transport system, permease component
LUW74_18820	COG0673	inositol 2-dehydrogenase activity
LUW74_18830	COG0714	Associated with various cellular activities
LUW74_18840	COG2304	oxidoreductase activity
LUW74_18845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW74_18850	COG0745	RESPONSE REGULATOR receiver
LUW74_18855	COG2205	protein histidine kinase activity
LUW74_18875	COG0419	ATPase involved in DNA repair
LUW74_18895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LUW74_18965	COG3962	Belongs to the TPP enzyme family
LUW74_18970	COG3718	enzyme involved in inositol metabolism
LUW74_18980	COG1082	Xylose isomerase domain protein TIM barrel
LUW74_18985	COG0673	inositol 2-dehydrogenase activity
LUW74_18990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LUW74_19000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LUW74_19005	COG0604	alcohol dehydrogenase
LUW74_19010	COG1476	TRANSCRIPTIONal
LUW74_19020	COG2814	Major facilitator Superfamily
LUW74_19030	COG0477	Major facilitator Superfamily
LUW74_19035	COG0456	acetyltransferase
LUW74_19035	COG1846	Transcriptional regulator
LUW74_19060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LUW74_19075	COG0386	Belongs to the glutathione peroxidase family
LUW74_19095	COG1316	TRANSCRIPTIONal
LUW74_19135	COG2018	Roadblock/LC7 domain
LUW74_19145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LUW74_19155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_19160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_19180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_19185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_19190	COG1116	anion transmembrane transporter activity
LUW74_19190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_19230	COG0277	FAD linked oxidase domain protein
LUW74_19280	COG0175	sulfate reduction
LUW74_19325	COG0438	transferase activity, transferring glycosyl groups
LUW74_19335	COG0438	transferase activity, transferring glycosyl groups
LUW74_19360	COG2326	polyphosphate kinase activity
LUW74_19420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LUW74_19425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LUW74_19435	COG1131	(ABC) transporter
LUW74_19450	COG0446	pyridine nucleotide-disulphide oxidoreductase
LUW74_19470	COG0531	amino acid
LUW74_19480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LUW74_19485	COG0549	Belongs to the carbamate kinase family
LUW74_19505	COG0516	GMP reductase activity
LUW74_19505	COG0517	IMP dehydrogenase activity
LUW74_19555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LUW74_19610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LUW74_19620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW74_19625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW74_19630	COG1937	Protein conserved in bacteria
LUW74_19665	COG1830	Aldolase
LUW74_19675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LUW74_19685	COG1960	acyl-CoA dehydrogenase activity
LUW74_19695	COG1129	ABC transporter
LUW74_19725	COG0145	ligase activity
LUW74_19750	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_19775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW74_19780	COG0531	amino acid
LUW74_19795	COG1595	DNA-templated transcription, initiation
LUW74_19810	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_19815	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_19820	COG1129	ABC transporter
LUW74_19825	COG1879	ABC-type sugar transport system periplasmic component
LUW74_19835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LUW74_19840	COG1349	DNA-binding transcription factor activity
LUW74_19875	COG1793	dna ligase
LUW74_19880	COG3540	Alkaline phosphatase
LUW74_19890	COG2186	Transcriptional regulator
LUW74_19895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW74_19905	COG2936	dipeptidyl-peptidase activity
LUW74_19920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LUW74_19950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LUW74_19970	COG0672	)-iron permease
LUW74_19980	COG0577	efflux transmembrane transporter activity
LUW74_19985	COG1136	(ABC) transporter
LUW74_19985	COG0577	efflux transmembrane transporter activity
LUW74_20005	COG0475	glutathione-regulated potassium exporter activity
LUW74_20025	COG3548	integral membrane protein
LUW74_20030	COG0745	RESPONSE REGULATOR receiver
LUW74_20035	COG2205	protein histidine kinase activity
LUW74_20040	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_20050	COG0183	Belongs to the thiolase family
LUW74_20055	COG1024	Enoyl-CoA hydratase
LUW74_20055	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW74_20060	COG0531	amino acid
LUW74_20075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LUW74_20080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LUW74_20090	COG1175	transmembrane transport
LUW74_20095	COG0395	ABC-type sugar transport system, permease component
LUW74_20115	COG1280	lysine exporter protein (LysE YggA)
LUW74_20120	COG0667	Aldo Keto reductase
LUW74_20135	COG2197	response regulator
LUW74_20145	COG2409	Drug exporters of the RND superfamily
LUW74_20195	COG1562	ergosterol biosynthetic process
LUW74_20205	COG1233	COG1233 Phytoene dehydrogenase and related
LUW74_20215	COG1657	PFAM Prenyltransferase squalene oxidase
LUW74_20245	COG2197	response regulator
LUW74_20265	COG0577	efflux transmembrane transporter activity
LUW74_20290	COG0800	Aldolase
LUW74_20295	COG0837	glucose binding
LUW74_20300	COG0129	dihydroxy-acid dehydratase activity
LUW74_20350	COG2084	Dehydrogenase
LUW74_20385	COG0297	glycogen (starch) synthase activity
LUW74_20405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW74_20405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW74_20410	COG3541	Predicted nucleotidyltransferase
LUW74_20420	COG1653	transport
LUW74_20455	COG0395	ABC-type sugar transport system, permease component
LUW74_20520	COG2814	Major facilitator Superfamily
LUW74_20530	COG1501	Belongs to the glycosyl hydrolase 31 family
LUW74_20535	COG0395	ABC-type sugar transport system, permease component
LUW74_20540	COG1175	transmembrane transport
LUW74_20555	COG4336	lyase activity
LUW74_20560	COG1984	allophanate hydrolase subunit 2
LUW74_20565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LUW74_20570	COG1914	H( )-stimulated, divalent metal cation uptake system
LUW74_20580	COG1802	Transcriptional regulator
LUW74_20585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LUW74_20590	COG0022	dehydrogenase e1 component
LUW74_20595	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW74_20615	COG1595	DNA-templated transcription, initiation
LUW74_20655	COG1940	carbohydrate kinase activity
LUW74_20660	COG0673	inositol 2-dehydrogenase activity
LUW74_20665	COG1653	transport
LUW74_20700	COG0300	oxidoreductase activity
LUW74_20745	COG2188	Transcriptional regulator
LUW74_20810	COG1482	cell wall glycoprotein biosynthetic process
LUW74_20825	COG1522	sequence-specific DNA binding
LUW74_20835	COG3281	Trehalose synthase
LUW74_20845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LUW74_20850	COG2226	methyltransferase
LUW74_20870	COG0477	Major facilitator Superfamily
LUW74_20890	COG4552	Acetyltransferase involved in intracellular survival and related
LUW74_20915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LUW74_20920	COG0531	amino acid
LUW74_20925	COG0569	domain protein
LUW74_20945	COG0477	Major facilitator Superfamily
LUW74_20950	COG0728	peptidoglycan biosynthetic process
LUW74_20965	COG1136	(ABC) transporter
LUW74_20975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW74_20985	COG0756	dUTP diphosphatase activity
LUW74_21025	COG0706	membrane insertase activity
LUW74_21035	COG0525	valine-tRNA ligase activity
LUW74_21075	COG0745	RESPONSE REGULATOR receiver
LUW74_21120	COG3402	PFAM membrane-flanked domain
LUW74_21145	COG1881	PFAM PEBP family protein
LUW74_21160	COG0288	reversible hydration of carbon dioxide
LUW74_21180	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
LUW74_21255	COG0251	oxidation-reduction process
LUW74_21260	COG0583	DNA-binding transcription factor activity
LUW74_21275	COG3321	synthase
LUW74_21275	COG0604	alcohol dehydrogenase
LUW74_21280	COG0604	alcohol dehydrogenase
LUW74_21280	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_21280	COG3321	synthase
LUW74_21300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LUW74_21340	COG1846	Transcriptional regulator
LUW74_21380	COG0517	IMP dehydrogenase activity
LUW74_21390	COG0464	growth
LUW74_21395	COG4451	ribulose bisphosphate carboxylase, small
LUW74_21400	COG1850	ribulose-bisphosphate carboxylase activity
LUW74_21405	COG0583	DNA-binding transcription factor activity
LUW74_21415	COG3268	Saccharopine dehydrogenase
LUW74_21425	COG2197	response regulator
LUW74_21430	COG0572	uridine kinase
LUW74_21455	COG0432	Pfam Uncharacterised protein family UPF0047
LUW74_21465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LUW74_21530	COG2378	regulation of single-species biofilm formation
LUW74_21550	COG2267	carboxylic ester hydrolase activity
LUW74_21590	COG0410	ABC transporter
LUW74_21615	COG1796	DNA polymerase
LUW74_21615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LUW74_21625	COG2197	response regulator
LUW74_21655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW74_21660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW74_21735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LUW74_21745	COG0514	ATP-dependent DNA helicase (RecQ)
LUW74_21775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LUW74_21805	COG2011	ABC-type metal ion transport system permease component
LUW74_21810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LUW74_21820	COG1309	transcriptional regulator
LUW74_21825	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_21840	COG4585	Histidine kinase
LUW74_21845	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LUW74_21860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LUW74_21885	COG2197	response regulator
LUW74_21895	COG0187	DNA topoisomerase II activity
LUW74_21900	COG1131	(ABC) transporter
LUW74_21925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW74_21935	COG4191	Histidine kinase
LUW74_21945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LUW74_21980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LUW74_21985	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LUW74_21990	COG1984	allophanate hydrolase subunit 2
LUW74_22010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LUW74_22090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LUW74_22095	COG0495	leucyl-tRNA aminoacylation
LUW74_22105	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_22115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LUW74_22120	COG0596	Alpha beta hydrolase
LUW74_22155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LUW74_22160	COG0277	FAD linked oxidase domain protein
LUW74_22195	COG0577	efflux transmembrane transporter activity
LUW74_22200	COG1136	(ABC) transporter
LUW74_22240	COG1683	Conserved Protein
LUW74_22255	COG1595	DNA-templated transcription, initiation
LUW74_22270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LUW74_22380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_22385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_22430	COG0406	alpha-ribazole phosphatase activity
LUW74_22440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LUW74_22445	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LUW74_22450	COG0501	Belongs to the peptidase M48B family
LUW74_22460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LUW74_22465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LUW74_22470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LUW74_22475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LUW74_22480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LUW74_22485	COG1530	ribonuclease E activity
LUW74_22500	COG0772	Belongs to the SEDS family
LUW74_22505	COG0768	penicillin binding
LUW74_22520	COG1077	Cell shape determining protein MreB Mrl
LUW74_22525	COG0105	UTP biosynthetic process
LUW74_22555	COG0525	valine-tRNA ligase activity
LUW74_22565	COG2197	response regulator
LUW74_22570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LUW74_22575	COG0740	serine-type endopeptidase activity
LUW74_22580	COG0740	serine-type endopeptidase activity
LUW74_22585	COG0544	peptidyl-prolyl cis-trans isomerase activity
LUW74_22595	COG2183	response to ionizing radiation
LUW74_22625	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_22630	COG1309	transcriptional regulator
LUW74_22650	COG1733	regulation of RNA biosynthetic process
LUW74_22655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LUW74_22690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LUW74_22735	COG4974	Belongs to the 'phage' integrase family
LUW74_22780	COG0596	Alpha beta hydrolase
LUW74_22880	COG0789	Transcriptional regulator
LUW74_22925	COG3629	intracellular signal transduction
LUW74_22925	COG3903	Transcriptional regulator
LUW74_22935	COG2409	Drug exporters of the RND superfamily
LUW74_22955	COG1140	nitrate reductase beta subunit
LUW74_22985	COG1129	ABC transporter
LUW74_22990	COG4214	carbohydrate transport
LUW74_22995	COG1609	Transcriptional regulator
LUW74_23005	COG2160	L-arabinose isomerase activity
LUW74_23040	COG0709	Synthesizes selenophosphate from selenide and ATP
LUW74_23090	COG2814	Major facilitator Superfamily
LUW74_23135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_23140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW74_23150	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_23155	COG0657	acetylesterase activity
LUW74_23170	COG4585	Histidine kinase
LUW74_23175	COG2197	response regulator
LUW74_23195	COG5002	protein histidine kinase activity
LUW74_23215	COG0698	ribose 5-phosphate isomerase
LUW74_23245	COG0310	cobalt ion transport
LUW74_23250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LUW74_23270	COG0154	amidase activity
LUW74_23280	COG0129	dihydroxy-acid dehydratase activity
LUW74_23305	COG2226	methyltransferase
LUW74_23335	COG0668	transmembrane transport
LUW74_23345	COG0366	Alpha amylase catalytic
LUW74_23355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_23360	COG0824	Thioesterase
LUW74_23365	COG4948	Mandelate Racemase Muconate Lactonizing
LUW74_23385	COG0629	single-stranded DNA binding
LUW74_23400	COG1648	precorrin-2 dehydrogenase activity
LUW74_23400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LUW74_23405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LUW74_23425	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LUW74_23430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_23455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_23470	COG2226	methyltransferase
LUW74_23480	COG4585	Histidine kinase
LUW74_23485	COG2197	response regulator
LUW74_23515	COG1309	transcriptional regulator
LUW74_23540	COG0515	serine threonine protein kinase
LUW74_23540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW74_23545	COG1280	lysine exporter protein (LysE YggA)
LUW74_23560	COG1492	cobalamin metabolic process
LUW74_23565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LUW74_23580	COG2160	L-arabinose isomerase activity
LUW74_23585	COG1879	ABC-type sugar transport system periplasmic component
LUW74_23590	COG1129	ABC transporter
LUW74_23600	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_23605	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_23645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LUW74_23655	COG1132	(ABC) transporter
LUW74_23695	COG1051	belongs to the nudix hydrolase family
LUW74_23700	COG1414	Transcriptional regulator
LUW74_23710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW74_23715	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_23720	COG1879	ABC-type sugar transport system periplasmic component
LUW74_23725	COG1129	ABC transporter
LUW74_23730	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_23750	COG0436	Aminotransferase
LUW74_23755	COG4977	sequence-specific DNA binding
LUW74_23770	COG4977	sequence-specific DNA binding
LUW74_23780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LUW74_23805	COG0640	Transcriptional regulator
LUW74_23820	COG0154	amidase activity
LUW74_23830	COG3153	acetyltransferase
LUW74_23830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW74_23840	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LUW74_23850	COG3940	Belongs to the glycosyl hydrolase 43 family
LUW74_23875	COG3119	arylsulfatase activity
LUW74_23880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW74_23890	COG1132	(ABC) transporter
LUW74_23900	COG2375	cellular response to nickel ion
LUW74_23900	COG1132	(ABC) transporter
LUW74_23915	COG4585	Histidine kinase
LUW74_23920	COG2197	response regulator
LUW74_23925	COG2319	Wd-40 repeat
LUW74_23925	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW74_23965	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_24010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_24025	COG1595	DNA-templated transcription, initiation
LUW74_24055	COG3339	Conserved Protein
LUW74_24070	COG4977	sequence-specific DNA binding
LUW74_24075	COG4447	cellulose binding
LUW74_24090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LUW74_24090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LUW74_24095	COG1349	DNA-binding transcription factor activity
LUW74_24105	COG1175	transmembrane transport
LUW74_24110	COG0395	ABC-type sugar transport system, permease component
LUW74_24155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LUW74_24160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW74_24165	COG3629	intracellular signal transduction
LUW74_24175	COG1960	acyl-CoA dehydrogenase activity
LUW74_24205	COG0156	8-amino-7-oxononanoate synthase activity
LUW74_24220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW74_24225	COG0156	8-amino-7-oxononanoate synthase activity
LUW74_24230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW74_24235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW74_24240	COG2197	response regulator
LUW74_24245	COG3469	chitinase activity
LUW74_24300	COG2815	serine threonine protein kinase
LUW74_24300	COG0515	serine threonine protein kinase
LUW74_24345	COG1116	anion transmembrane transporter activity
LUW74_24380	COG3903	Transcriptional regulator
LUW74_24380	COG3629	intracellular signal transduction
LUW74_24430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LUW74_24435	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LUW74_24475	COG1309	transcriptional regulator
LUW74_24525	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LUW74_24565	COG2226	methyltransferase
LUW74_24580	COG1047	Peptidyl-prolyl cis-trans
LUW74_24585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW74_24660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW74_24670	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LUW74_24680	COG2197	response regulator
LUW74_24735	COG1309	transcriptional regulator
LUW74_24750	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_24755	COG1309	transcriptional regulator
LUW74_24790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW74_24800	COG3119	arylsulfatase activity
LUW74_24820	COG0444	Belongs to the ABC transporter superfamily
LUW74_24825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW74_24830	COG0601	transmembrane transport
LUW74_24845	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LUW74_24860	COG1846	Transcriptional regulator
LUW74_24865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LUW74_24895	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW74_24895	COG2319	Wd-40 repeat
LUW74_24900	COG2409	Drug exporters of the RND superfamily
LUW74_24910	COG1695	Transcriptional regulator
LUW74_24915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LUW74_24925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_24940	COG0402	S-adenosylhomocysteine deaminase activity
LUW74_25020	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW74_25035	COG0702	epimerase
LUW74_25050	COG0739	heme binding
LUW74_25050	COG0741	lytic transglycosylase activity
LUW74_25050	COG1196	nuclear chromosome segregation
LUW74_25065	COG0778	Nitroreductase
LUW74_25065	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LUW74_25085	COG3387	PFAM Glycoside hydrolase 15-related
LUW74_25090	COG1063	alcohol dehydrogenase
LUW74_25100	COG3629	intracellular signal transduction
LUW74_25100	COG3903	Transcriptional regulator
LUW74_25125	COG3629	intracellular signal transduction
LUW74_25125	COG3903	Transcriptional regulator
LUW74_25155	COG0300	oxidoreductase activity
LUW74_25170	COG0300	oxidoreductase activity
LUW74_25205	COG0477	Major facilitator Superfamily
LUW74_25260	COG1414	Transcriptional regulator
LUW74_25265	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LUW74_25275	COG4608	Belongs to the ABC transporter superfamily
LUW74_25315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LUW74_25320	COG1960	acyl-CoA dehydrogenase activity
LUW74_25335	COG0515	serine threonine protein kinase
LUW74_25365	COG3260	NADH ubiquinone oxidoreductase 20
LUW74_25375	COG0650	Formate hydrogenlyase subunit 4
LUW74_25385	COG0651	ATP synthesis coupled electron transport
LUW74_25390	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LUW74_25390	COG3261	NADH dehydrogenase
LUW74_25400	COG0183	Belongs to the thiolase family
LUW74_25410	COG1960	acyl-CoA dehydrogenase activity
LUW74_25420	COG1960	acyl-CoA dehydrogenase activity
LUW74_25425	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_25440	COG1090	epimerase
LUW74_25450	COG1090	epimerase
LUW74_25455	COG1595	DNA-templated transcription, initiation
LUW74_25460	COG0596	Alpha beta hydrolase
LUW74_25490	COG1309	transcriptional regulator
LUW74_25505	COG2267	carboxylic ester hydrolase activity
LUW74_25535	COG0745	RESPONSE REGULATOR receiver
LUW74_25540	COG2205	protein histidine kinase activity
LUW74_25550	COG1136	(ABC) transporter
LUW74_25580	COG1960	acyl-CoA dehydrogenase activity
LUW74_25590	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LUW74_25630	COG0726	polysaccharide deacetylase
LUW74_25635	COG1024	Enoyl-CoA hydratase
LUW74_25645	COG1073	alpha beta
LUW74_25645	COG2226	methyltransferase
LUW74_25650	COG0215	cysteine-tRNA ligase activity
LUW74_25680	COG0006	proline dipeptidase activity
LUW74_25695	COG0604	alcohol dehydrogenase
LUW74_25695	COG3321	synthase
LUW74_25705	COG4585	Histidine kinase
LUW74_25755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_25775	COG2255	four-way junction helicase activity
LUW74_25785	COG1674	ftsk spoiiie
LUW74_25815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LUW74_25825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LUW74_25830	COG1316	TRANSCRIPTIONal
LUW74_25850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW74_25870	COG1132	(ABC) transporter
LUW74_25875	COG1132	(ABC) transporter
LUW74_25895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LUW74_25950	COG1053	succinate dehydrogenase
LUW74_25980	COG0515	serine threonine protein kinase
LUW74_25985	COG1316	TRANSCRIPTIONal
LUW74_26045	COG3883	PFAM NLP P60 protein
LUW74_26045	COG0791	NLP P60 protein
LUW74_26085	COG2885	chlorophyll binding
LUW74_26100	COG4585	Histidine kinase
LUW74_26125	COG2894	cell division
LUW74_26165	COG0542	response to heat
LUW74_26195	COG0791	NLP P60 protein
LUW74_26200	COG0494	nUDIX hydrolase
LUW74_26210	COG0402	S-adenosylhomocysteine deaminase activity
LUW74_26260	COG0012	GTP binding
LUW74_26265	COG1322	Protein conserved in bacteria
LUW74_26275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LUW74_26295	COG1722	exodeoxyribonuclease VII activity
LUW74_26320	COG1131	(ABC) transporter
LUW74_26355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LUW74_26355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LUW74_26365	COG0114	fumarate hydratase activity
LUW74_26375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LUW74_26380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LUW74_26395	COG1331	Highly conserved protein containing a thioredoxin domain
LUW74_26405	COG1234	tRNA 3'-trailer cleavage
LUW74_26425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW74_26435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LUW74_26445	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LUW74_26460	COG1714	RDD family
LUW74_26465	COG0308	aminopeptidase N
LUW74_26480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LUW74_26510	COG0657	acetylesterase activity
LUW74_26510	COG2755	lipolytic protein G-D-S-L family
LUW74_26520	COG2409	Drug exporters of the RND superfamily
LUW74_26590	COG2205	protein histidine kinase activity
LUW74_26605	COG0604	alcohol dehydrogenase
LUW74_26605	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_26605	COG3321	synthase
LUW74_26610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW74_26635	COG2046	Belongs to the sulfate adenylyltransferase family
LUW74_26640	COG0529	Catalyzes the synthesis of activated sulfate
LUW74_26640	COG2046	Belongs to the sulfate adenylyltransferase family
LUW74_26645	COG0730	response to heat
LUW74_26730	COG1218	3'(2'),5'-bisphosphate nucleotidase
LUW74_26740	COG0193	aminoacyl-tRNA hydrolase activity
LUW74_26745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LUW74_26750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LUW74_26755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LUW74_26770	COG1309	transcriptional regulator
LUW74_26775	COG4106	trans-aconitate 2-methyltransferase activity
LUW74_26785	COG0154	amidase activity
LUW74_26805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LUW74_26810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LUW74_26810	COG4124	Belongs to the glycosyl hydrolase 26 family
LUW74_26830	COG0084	hydrolase, TatD family'
LUW74_26835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LUW74_26880	COG1609	Transcriptional regulator
LUW74_26885	COG0598	Magnesium transport protein CorA
LUW74_26900	COG0583	DNA-binding transcription factor activity
LUW74_26915	COG0154	amidase activity
LUW74_26960	COG0515	serine threonine protein kinase
LUW74_26960	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW74_26970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_26995	COG3655	Transcriptional regulator
LUW74_27005	COG0477	Major facilitator Superfamily
LUW74_27085	COG0457	Tetratricopeptide repeat
LUW74_27100	COG2255	four-way junction helicase activity
LUW74_27110	COG0604	alcohol dehydrogenase
LUW74_27110	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_27110	COG3321	synthase
LUW74_27120	COG0640	Transcriptional regulator
LUW74_27130	COG1132	(ABC) transporter
LUW74_27185	COG1280	lysine exporter protein (LysE YggA)
LUW74_27190	COG1309	transcriptional regulator
LUW74_27205	COG2197	response regulator
LUW74_27215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LUW74_27230	COG0438	transferase activity, transferring glycosyl groups
LUW74_27245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LUW74_27275	COG2124	cytochrome p450
LUW74_27280	COG3851	Histidine kinase
LUW74_27285	COG2197	response regulator
LUW74_27295	COG0515	serine threonine protein kinase
LUW74_27300	COG2815	serine threonine protein kinase
LUW74_27300	COG0515	serine threonine protein kinase
LUW74_27305	COG0515	serine threonine protein kinase
LUW74_27310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LUW74_27310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LUW74_27390	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_27425	COG1846	Transcriptional regulator
LUW74_27435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW74_27455	COG1024	Enoyl-CoA hydratase
LUW74_27465	COG2070	2-Nitropropane dioxygenase
LUW74_27495	COG1216	Glycosyl transferase, family 2
LUW74_27510	COG1960	acyl-CoA dehydrogenase activity
LUW74_27525	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_27600	COG0641	radical SAM
LUW74_27625	COG0583	DNA-binding transcription factor activity
LUW74_27655	COG1492	cobalamin metabolic process
LUW74_27660	COG1473	amidohydrolase
LUW74_27675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LUW74_27680	COG0793	Belongs to the peptidase S41A family
LUW74_27685	COG2177	Part of the ABC transporter FtsEX involved in
LUW74_27690	COG2884	Cell division ATP-binding protein ftsE
LUW74_27705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LUW74_27735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_27745	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_27750	COG1595	DNA-templated transcription, initiation
LUW74_27770	COG1131	(ABC) transporter
LUW74_27780	COG1011	Hydrolase
LUW74_27800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW74_27805	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW74_27815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LUW74_27820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW74_27830	COG1263	PTS System
LUW74_27830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LUW74_27830	COG2190	(PTS) system
LUW74_27835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LUW74_27840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LUW74_27850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LUW74_27855	COG2188	Transcriptional regulator
LUW74_27860	COG1263	PTS System
LUW74_27870	COG0653	protein targeting
LUW74_27880	COG3214	Protein conserved in bacteria
LUW74_27885	COG2197	response regulator
LUW74_27890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LUW74_27895	COG1040	competence protein
LUW74_27905	COG5401	PFAM Sporulation and spore germination
LUW74_27910	COG5002	protein histidine kinase activity
LUW74_27910	COG5000	phosphorelay sensor kinase activity
LUW74_27915	COG0745	RESPONSE REGULATOR receiver
LUW74_27935	COG0714	Associated with various cellular activities
LUW74_27965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LUW74_27970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LUW74_27990	COG2197	response regulator
LUW74_27995	COG4585	Histidine kinase
LUW74_28010	COG2835	tetraacyldisaccharide 4'-kinase activity
LUW74_28015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LUW74_28060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LUW74_28065	COG0778	Nitroreductase
LUW74_28065	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LUW74_28070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LUW74_28080	COG0583	DNA-binding transcription factor activity
LUW74_28110	COG0438	transferase activity, transferring glycosyl groups
LUW74_28115	COG1073	alpha beta
LUW74_28115	COG2226	methyltransferase
LUW74_28125	COG3118	belongs to the thioredoxin family
LUW74_28155	COG3594	Acyltransferase
LUW74_28160	COG3594	Acyltransferase
LUW74_28165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW74_28170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW74_28180	COG0438	transferase activity, transferring glycosyl groups
LUW74_28220	COG0438	transferase activity, transferring glycosyl groups
LUW74_28240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LUW74_28260	COG3973	AAA domain
LUW74_28295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LUW74_28315	COG1316	TRANSCRIPTIONal
LUW74_28335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LUW74_28340	COG1832	CoA-binding protein
LUW74_28355	COG3850	Histidine kinase
LUW74_28375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LUW74_28390	COG2205	protein histidine kinase activity
LUW74_28395	COG0745	RESPONSE REGULATOR receiver
LUW74_28440	COG1024	Enoyl-CoA hydratase
LUW74_28450	COG4941	Belongs to the sigma-70 factor family
LUW74_28460	COG3795	YCII-related domain
LUW74_28475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LUW74_28485	COG1432	Conserved Protein
LUW74_28560	COG1674	ftsk spoiiie
LUW74_28575	COG4770	biotin carboxylase activity
LUW74_28600	COG2197	response regulator
LUW74_28630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LUW74_28640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LUW74_28680	COG0640	Transcriptional regulator
LUW74_28685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LUW74_28700	COG2315	Protein conserved in bacteria
LUW74_28735	COG0583	DNA-binding transcription factor activity
LUW74_28760	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_28770	COG2936	dipeptidyl-peptidase activity
LUW74_28785	COG1079	Belongs to the binding-protein-dependent transport system permease family
LUW74_28795	COG3845	ABC transporter
LUW74_28800	COG1744	ABC transporter substrate-binding protein PnrA-like
LUW74_28805	COG1473	amidohydrolase
LUW74_28805	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW74_28810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW74_28815	COG1686	Belongs to the peptidase S11 family
LUW74_28825	COG1295	ribonuclease BN
LUW74_28840	COG4535	Mg2 and Co2 transporter CorC
LUW74_28850	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LUW74_28865	COG0326	Molecular chaperone. Has ATPase activity
LUW74_28875	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW74_28875	COG1672	PFAM Archaeal ATPase
LUW74_28935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LUW74_28950	COG0138	bifunctional purine biosynthesis protein purh
LUW74_28975	COG0045	succinate-CoA ligase (ADP-forming) activity
LUW74_28985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_29000	COG2223	nitrite transmembrane transporter activity
LUW74_29005	COG2207	Transcriptional regulator
LUW74_29025	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LUW74_29045	COG1490	D-aminoacyl-tRNA deacylase activity
LUW74_29050	COG3246	L-lysine catabolic process to acetate
LUW74_29065	COG2807	transmembrane transport
LUW74_29070	COG2186	Transcriptional regulator
LUW74_29110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LUW74_29115	COG1309	transcriptional regulator
LUW74_29120	COG2409	Drug exporters of the RND superfamily
LUW74_29175	COG1595	DNA-templated transcription, initiation
LUW74_29195	COG2084	Dehydrogenase
LUW74_29230	COG3442	glutamine amidotransferase
LUW74_29235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LUW74_29265	COG0640	Transcriptional regulator
LUW74_29345	COG3119	arylsulfatase activity
LUW74_29370	COG1316	TRANSCRIPTIONal
LUW74_29485	COG1404	Belongs to the peptidase S8 family
LUW74_29505	COG4842	Belongs to the WXG100 family
LUW74_29520	COG1674	ftsk spoiiie
LUW74_29595	COG0745	RESPONSE REGULATOR receiver
LUW74_29620	COG0456	acetyltransferase
LUW74_29625	COG0737	Belongs to the 5'-nucleotidase family
LUW74_29625	COG4085	toxin activity
LUW74_29625	COG1525	nuclease
LUW74_29630	COG0306	phosphate transporter
LUW74_29645	COG0464	growth
LUW74_29670	COG0745	RESPONSE REGULATOR receiver
LUW74_29685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW74_29695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LUW74_29725	COG1024	Enoyl-CoA hydratase
LUW74_29735	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_29770	COG1902	pentaerythritol trinitrate reductase activity
LUW74_29775	COG4566	intracellular signal transduction
LUW74_29815	COG3118	belongs to the thioredoxin family
LUW74_29820	COG0071	Belongs to the small heat shock protein (HSP20) family
LUW74_29830	COG2197	response regulator
LUW74_29840	COG2814	Major facilitator Superfamily
LUW74_29850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW74_29850	COG1672	PFAM Archaeal ATPase
LUW74_29860	COG0443	Heat shock 70 kDa protein
LUW74_29865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LUW74_29880	COG0542	response to heat
LUW74_29885	COG1793	dna ligase
LUW74_29885	COG3285	dna ligase
LUW74_29900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LUW74_30000	COG0667	Aldo Keto reductase
LUW74_30010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW74_30015	COG3387	PFAM Glycoside hydrolase 15-related
LUW74_30035	COG0431	NADPH-dependent FMN reductase
LUW74_30045	COG0028	Belongs to the TPP enzyme family
LUW74_30060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LUW74_30085	COG1191	sigma factor activity
LUW74_30115	COG1234	tRNA 3'-trailer cleavage
LUW74_30125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_30130	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_30155	COG0596	Alpha beta hydrolase
LUW74_30165	COG2409	Drug exporters of the RND superfamily
LUW74_30170	COG2409	Drug exporters of the RND superfamily
LUW74_30180	COG0745	RESPONSE REGULATOR receiver
LUW74_30215	COG1132	(ABC) transporter
LUW74_30220	COG1132	(ABC) transporter
LUW74_30225	COG0515	serine threonine protein kinase
LUW74_30230	COG0515	serine threonine protein kinase
LUW74_30260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LUW74_30275	COG1309	transcriptional regulator
LUW74_30285	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_30290	COG1024	Enoyl-CoA hydratase
LUW74_30305	COG0183	Belongs to the thiolase family
LUW74_30335	COG1129	ABC transporter
LUW74_30350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LUW74_30360	COG1960	acyl-CoA dehydrogenase activity
LUW74_30365	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_30385	COG2837	iron assimilation
LUW74_30430	COG3629	intracellular signal transduction
LUW74_30430	COG3903	Transcriptional regulator
LUW74_30455	COG4221	oxidoreductase activity
LUW74_30475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_30480	COG1116	anion transmembrane transporter activity
LUW74_30480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_30490	COG0431	NADPH-dependent FMN reductase
LUW74_30530	COG3387	PFAM Glycoside hydrolase 15-related
LUW74_30545	COG0477	Major facilitator Superfamily
LUW74_30580	COG2226	methyltransferase
LUW74_30660	COG2018	Roadblock/LC7 domain
LUW74_30705	COG1129	ABC transporter
LUW74_30710	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_30730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LUW74_30750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW74_30755	COG3386	PFAM SMP-30 Gluconolaconase
LUW74_30765	COG1609	Transcriptional regulator
LUW74_30775	COG0596	Alpha beta hydrolase
LUW74_30845	COG1959	2 iron, 2 sulfur cluster binding
LUW74_30860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LUW74_30865	COG1115	amino acid carrier protein
LUW74_30875	COG1793	dna ligase
LUW74_30910	COG2353	YceI-like domain
LUW74_30965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LUW74_31050	COG1021	2,3-dihydroxybenzoate-AMP ligase
LUW74_31065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW74_31140	COG1309	transcriptional regulator
LUW74_31145	COG0604	alcohol dehydrogenase
LUW74_31155	COG5398	heme oxygenase
LUW74_31185	COG4558	Periplasmic binding protein
LUW74_31190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW74_31195	COG1120	ATPase activity
LUW74_31210	COG2186	Transcriptional regulator
LUW74_31215	COG2807	transmembrane transport
LUW74_31225	COG2814	Major facilitator Superfamily
LUW74_31260	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_31295	COG0596	Alpha beta hydrolase
LUW74_31305	COG0066	3-isopropylmalate dehydratase activity
LUW74_31310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LUW74_31315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LUW74_31330	COG1414	Transcriptional regulator
LUW74_31355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_31360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_31365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_31365	COG1116	anion transmembrane transporter activity
LUW74_31390	COG1454	alcohol dehydrogenase
LUW74_31400	COG0583	DNA-binding transcription factor activity
LUW74_31415	COG1309	transcriptional regulator
LUW74_31425	COG1414	Transcriptional regulator
LUW74_31435	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_31440	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_31445	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_31460	COG3594	Acyltransferase
LUW74_31510	COG0438	transferase activity, transferring glycosyl groups
LUW74_31520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LUW74_31545	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_31555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LUW74_31575	COG3279	Response regulator of the LytR AlgR family
LUW74_31580	COG3275	phosphorelay sensor kinase activity
LUW74_31600	COG1279	arginine transmembrane transporter activity
LUW74_31605	COG1917	Cupin 2, conserved barrel domain protein
LUW74_31605	COG4977	sequence-specific DNA binding
LUW74_31645	COG0596	Alpha beta hydrolase
LUW74_31670	COG1960	acyl-CoA dehydrogenase activity
LUW74_31680	COG1024	Enoyl-CoA hydratase
LUW74_31685	COG1960	acyl-CoA dehydrogenase activity
LUW74_31705	COG0737	Belongs to the 5'-nucleotidase family
LUW74_31735	COG4977	sequence-specific DNA binding
LUW74_31745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LUW74_31770	COG4935	Belongs to the peptidase S8 family
LUW74_31770	COG2234	aminopeptidase activity
LUW74_31785	COG1960	acyl-CoA dehydrogenase activity
LUW74_31795	COG0477	Major facilitator Superfamily
LUW74_31875	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_31955	COG2274	protein secretion by the type I secretion system
LUW74_31960	COG3903	Transcriptional regulator
LUW74_31960	COG3629	intracellular signal transduction
LUW74_31970	COG3903	Transcriptional regulator
LUW74_31970	COG3629	intracellular signal transduction
LUW74_31980	COG0477	Major facilitator Superfamily
LUW74_32020	COG1309	transcriptional regulator
LUW74_32030	COG0583	DNA-binding transcription factor activity
LUW74_32055	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_32095	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_32125	COG2423	ornithine cyclodeaminase activity
LUW74_32135	COG0583	DNA-binding transcription factor activity
LUW74_32155	COG0243	molybdopterin cofactor binding
LUW74_32170	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LUW74_32180	COG2186	Transcriptional regulator
LUW74_32190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_32195	COG1116	anion transmembrane transporter activity
LUW74_32195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_32205	COG2009	succinate dehydrogenase
LUW74_32210	COG1053	succinate dehydrogenase
LUW74_32215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LUW74_32220	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LUW74_32225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW74_32230	COG2721	sulfolactate sulfo-lyase activity
LUW74_32235	COG2721	sulfolactate sulfo-lyase activity
LUW74_32240	COG2197	response regulator
LUW74_32255	COG0473	3-isopropylmalate dehydrogenase activity
LUW74_32260	COG1802	Transcriptional regulator
LUW74_32270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW74_32280	COG5522	Integral membrane protein (intg_mem_TP0381)
LUW74_32305	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_32320	COG3568	Endonuclease Exonuclease Phosphatase
LUW74_32345	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_32350	COG1309	transcriptional regulator
LUW74_32355	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_32365	COG1129	ABC transporter
LUW74_32410	COG0464	growth
LUW74_32415	COG0583	DNA-binding transcription factor activity
LUW74_32420	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_32470	COG0583	DNA-binding transcription factor activity
LUW74_32475	COG0584	glycerophosphoryl diester phosphodiesterase
LUW74_32485	COG1113	amino acid transport
LUW74_32515	COG0791	NLP P60 protein
LUW74_32515	COG3883	PFAM NLP P60 protein
LUW74_32670	COG1960	acyl-CoA dehydrogenase activity
LUW74_32685	COG2207	Transcriptional regulator
LUW74_32695	COG1793	dna ligase
LUW74_32710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LUW74_32720	COG3547	Transposase (IS116 IS110 IS902 family)
LUW74_32780	COG1518	maintenance of DNA repeat elements
LUW74_32785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LUW74_32825	COG0358	DNA primase activity
LUW74_32895	COG0539	negative regulation of cytoplasmic translation
LUW74_33030	COG1846	Transcriptional regulator
LUW74_33050	COG1942	4-Oxalocrotonate Tautomerase
LUW74_33080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_33090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_33095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW74_33095	COG1116	anion transmembrane transporter activity
LUW74_33100	COG2186	Transcriptional regulator
LUW74_33145	COG0604	alcohol dehydrogenase
LUW74_33200	COG0583	DNA-binding transcription factor activity
LUW74_33205	COG1760	l-serine dehydratase
LUW74_33210	COG3620	sequence-specific DNA binding
LUW74_33220	COG0765	amino acid transport
LUW74_33225	COG1126	abc transporter atp-binding protein
LUW74_33230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_33270	COG1132	(ABC) transporter
LUW74_33275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_33305	COG2226	methyltransferase
LUW74_33320	COG1082	Xylose isomerase domain protein TIM barrel
LUW74_33325	COG2814	Major facilitator Superfamily
LUW74_33350	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW74_33390	COG0492	ferredoxin-NADP+ reductase activity
LUW74_33420	COG0438	transferase activity, transferring glycosyl groups
LUW74_33440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LUW74_33475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LUW74_33500	COG0464	growth
LUW74_33545	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_33585	COG2267	carboxylic ester hydrolase activity
LUW74_33600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LUW74_33680	COG0167	dihydroorotate dehydrogenase activity
LUW74_33685	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW74_33705	COG1309	transcriptional regulator
LUW74_33730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LUW74_33785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LUW74_33790	COG0047	phosphoribosylformylglycinamidine synthase activity
LUW74_33800	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LUW74_33815	COG0022	dehydrogenase e1 component
LUW74_33820	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW74_33835	COG0697	spore germination
LUW74_33845	COG1960	acyl-CoA dehydrogenase activity
LUW74_33855	COG2076	Multidrug Resistance protein
LUW74_33870	COG4221	oxidoreductase activity
LUW74_33925	COG0406	alpha-ribazole phosphatase activity
LUW74_33925	COG0494	nUDIX hydrolase
LUW74_33930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LUW74_33950	COG1595	DNA-templated transcription, initiation
LUW74_33955	COG2204	response regulator
LUW74_33960	COG4251	negative regulation of phosphorylation
LUW74_33965	COG0784	Response regulator, receiver
LUW74_33995	COG1799	cell septum assembly
LUW74_34010	COG0745	RESPONSE REGULATOR receiver
LUW74_34020	COG2205	protein histidine kinase activity
LUW74_34030	COG1960	acyl-CoA dehydrogenase activity
LUW74_34070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW74_34125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LUW74_34155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LUW74_34200	COG0416	fatty acid biosynthetic process
LUW74_34210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LUW74_34220	COG1233	COG1233 Phytoene dehydrogenase and related
LUW74_34230	COG2770	Histidine kinase
LUW74_34230	COG2208	phosphoserine phosphatase activity
LUW74_34245	COG0596	Alpha beta hydrolase
LUW74_34270	COG2197	response regulator
LUW74_34285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LUW74_34290	COG0543	2 iron, 2 sulfur cluster binding
LUW74_34290	COG0633	Ferredoxin
LUW74_34300	COG1064	alcohol dehydrogenase
LUW74_34320	COG2706	6-phosphogluconolactonase activity
LUW74_34325	COG1733	regulation of RNA biosynthetic process
LUW74_34425	COG1136	(ABC) transporter
LUW74_34425	COG0577	efflux transmembrane transporter activity
LUW74_34450	COG2815	serine threonine protein kinase
LUW74_34450	COG0515	serine threonine protein kinase
LUW74_34470	COG1247	-acetyltransferase
LUW74_34550	COG0714	Associated with various cellular activities
LUW74_34650	COG1733	regulation of RNA biosynthetic process
LUW74_34665	COG0028	Belongs to the TPP enzyme family
LUW74_34705	COG1309	transcriptional regulator
LUW74_34710	COG3321	synthase
LUW74_34710	COG0604	alcohol dehydrogenase
LUW74_34710	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_34755	COG0247	lactate metabolic process
LUW74_34755	COG2181	nitrate reductase activity
LUW74_34775	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW74_34780	COG0477	Major facilitator Superfamily
LUW74_34805	COG1595	DNA-templated transcription, initiation
LUW74_34810	COG1404	Belongs to the peptidase S8 family
LUW74_34865	COG0443	Heat shock 70 kDa protein
LUW74_34870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LUW74_34875	COG0484	heat shock protein binding
LUW74_34880	COG0789	Transcriptional regulator
LUW74_34885	COG0542	response to heat
LUW74_34910	COG4941	Belongs to the sigma-70 factor family
LUW74_34915	COG3795	YCII-related domain
LUW74_34925	COG0596	Alpha beta hydrolase
LUW74_34955	COG1432	Conserved Protein
LUW74_34970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LUW74_34980	COG0586	Pfam SNARE associated Golgi protein
LUW74_35025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LUW74_35040	COG0151	Belongs to the GarS family
LUW74_35045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LUW74_35050	COG0633	Ferredoxin
LUW74_35050	COG3217	Mosc domain protein beta barrel domain protein
LUW74_35060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LUW74_35080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW74_35095	COG2268	Band 7 protein
LUW74_35110	COG0204	Acyl-transferase
LUW74_35110	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_35120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_35145	COG0515	serine threonine protein kinase
LUW74_35155	COG1253	flavin adenine dinucleotide binding
LUW74_35175	COG1950	PFAM Membrane protein of
LUW74_35185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LUW74_35190	COG0514	ATP-dependent DNA helicase (RecQ)
LUW74_35210	COG0745	RESPONSE REGULATOR receiver
LUW74_35225	COG0596	Alpha beta hydrolase
LUW74_35230	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_35255	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_35310	COG0022	dehydrogenase e1 component
LUW74_35315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LUW74_35325	COG0022	dehydrogenase e1 component
LUW74_35330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LUW74_35335	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW74_35345	COG4948	Mandelate Racemase Muconate Lactonizing
LUW74_35360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_35380	COG0431	NADPH-dependent FMN reductase
LUW74_35390	COG2271	Major facilitator Superfamily
LUW74_35415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_35420	COG3485	protocatechuate 3,4-dioxygenase
LUW74_35460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LUW74_35465	COG0477	Major facilitator Superfamily
LUW74_35475	COG0583	DNA-binding transcription factor activity
LUW74_35495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_35505	COG0559	Belongs to the binding-protein-dependent transport system permease family
LUW74_35540	COG1960	acyl-CoA dehydrogenase activity
LUW74_35545	COG1960	acyl-CoA dehydrogenase activity
LUW74_35550	COG0183	Belongs to the thiolase family
LUW74_35560	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_35595	COG2130	NADP-dependent
LUW74_35620	COG1233	COG1233 Phytoene dehydrogenase and related
LUW74_35635	COG0789	Transcriptional regulator
LUW74_35645	COG0583	DNA-binding transcription factor activity
LUW74_35650	COG1024	Enoyl-CoA hydratase
LUW74_35655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_35660	COG0477	Major facilitator Superfamily
LUW74_35735	COG0477	Major facilitator Superfamily
LUW74_35740	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW74_35740	COG2319	Wd-40 repeat
LUW74_35745	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LUW74_35770	COG2197	response regulator
LUW74_35780	COG3629	intracellular signal transduction
LUW74_35780	COG3903	Transcriptional regulator
LUW74_35855	COG0477	Major facilitator Superfamily
LUW74_35865	COG1476	TRANSCRIPTIONal
LUW74_35875	COG1846	Transcriptional regulator
LUW74_35885	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LUW74_35890	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW74_35910	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_35915	COG1595	DNA-templated transcription, initiation
LUW74_35945	COG1846	Transcriptional regulator
LUW74_36030	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LUW74_36050	COG0604	alcohol dehydrogenase
LUW74_36060	COG0561	phosphatase activity
LUW74_36065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LUW74_36070	COG2226	methyltransferase
LUW74_36075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LUW74_36090	COG5650	phosphatidylinositol metabolic process
LUW74_36120	COG5002	protein histidine kinase activity
LUW74_36125	COG0745	RESPONSE REGULATOR receiver
LUW74_36155	COG2235	arginine
LUW74_36165	COG5002	protein histidine kinase activity
LUW74_36175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW74_36190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LUW74_36240	COG1595	DNA-templated transcription, initiation
LUW74_36275	COG0140	phosphoribosyl-ATP diphosphatase activity
LUW74_36275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LUW74_36320	COG0789	Transcriptional regulator
LUW74_36355	COG0789	Transcriptional regulator
LUW74_36435	COG0477	Major facilitator Superfamily
LUW74_36440	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_36470	COG2018	Roadblock/LC7 domain
LUW74_36490	COG1136	(ABC) transporter
LUW74_36490	COG0577	efflux transmembrane transporter activity
LUW74_36495	COG1136	(ABC) transporter
LUW74_36510	COG0745	RESPONSE REGULATOR receiver
LUW74_36520	COG2205	protein histidine kinase activity
LUW74_36530	COG4585	Histidine kinase
LUW74_36535	COG2197	response regulator
LUW74_36550	COG1716	ATPase activity
LUW74_36565	COG0768	penicillin binding
LUW74_36570	COG0515	serine threonine protein kinase
LUW74_36575	COG0515	serine threonine protein kinase
LUW74_36590	COG3764	Sortase (surface protein transpeptidase)
LUW74_36605	COG0705	Rhomboid family
LUW74_36625	COG0596	Alpha beta hydrolase
LUW74_36630	COG0513	Belongs to the DEAD box helicase family
LUW74_36635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW74_36655	COG1271	oxidase subunit
LUW74_36660	COG1294	oxidase, subunit
LUW74_36665	COG4988	ABC transporter
LUW74_36695	COG0154	amidase activity
LUW74_36700	COG1609	Transcriptional regulator
LUW74_36725	COG0667	Aldo Keto reductase
LUW74_36735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_36745	COG0402	S-adenosylhomocysteine deaminase activity
LUW74_36755	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_36765	COG1247	-acetyltransferase
LUW74_36770	COG2226	methyltransferase
LUW74_36775	COG0640	Transcriptional regulator
LUW74_36785	COG0640	Transcriptional regulator
LUW74_36855	COG0346	lactoylglutathione lyase activity
LUW74_36865	COG3266	domain, Protein
LUW74_36870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LUW74_36880	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LUW74_36885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LUW74_36895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LUW74_36900	COG0592	DNA-directed DNA polymerase activity
LUW74_36905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LUW74_36910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LUW74_36915	COG0594	ribonuclease P activity
LUW74_36920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LUW74_36925	COG0706	membrane insertase activity
LUW74_36940	COG0357	Ribosomal RNA small subunit methyltransferase G
LUW74_36945	COG1192	Involved in chromosome partitioning
LUW74_36960	COG1181	Belongs to the D-alanine--D-alanine ligase family
LUW74_36965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW74_36975	COG3118	belongs to the thioredoxin family
LUW74_36980	COG0492	ferredoxin-NADP+ reductase activity
LUW74_37000	COG1595	DNA-templated transcription, initiation
LUW74_37010	COG0515	serine threonine protein kinase
LUW74_37010	COG2815	serine threonine protein kinase
LUW74_37035	COG0617	tRNA 3'-terminal CCA addition
LUW74_37040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LUW74_37050	COG4166	transmembrane transport
LUW74_37075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW74_37080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW74_37095	COG0789	Transcriptional regulator
LUW74_37115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LUW74_37130	COG0360	Binds together with S18 to 16S ribosomal RNA
LUW74_37135	COG0629	single-stranded DNA binding
LUW74_37140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LUW74_37145	COG0359	binds to the 23S rRNA
LUW74_37165	COG0305	Participates in initiation and elongation during chromosome replication
LUW74_37170	COG1252	NADH dehydrogenase
LUW74_37185	COG2318	DinB family
LUW74_37195	COG1595	DNA-templated transcription, initiation
LUW74_37210	COG1846	Transcriptional regulator
LUW74_37230	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW74_37265	COG0592	DNA-directed DNA polymerase activity
LUW74_37285	COG0537	adenosine 5'-monophosphoramidase activity
LUW74_37345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LUW74_37370	COG2186	Transcriptional regulator
LUW74_37420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LUW74_37425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LUW74_37445	COG0189	ligase activity
LUW74_37450	COG0246	Mannitol dehydrogenase
LUW74_37460	COG0745	RESPONSE REGULATOR receiver
LUW74_37500	COG1846	Transcriptional regulator
LUW74_37535	COG3903	Transcriptional regulator
LUW74_37535	COG3629	intracellular signal transduction
LUW74_37545	COG0860	N-Acetylmuramoyl-L-alanine amidase
LUW74_37585	COG0515	serine threonine protein kinase
LUW74_37670	COG1104	cysteine desulfurase activity
LUW74_37685	COG0419	ATPase involved in DNA repair
LUW74_37755	COG1408	metallophosphoesterase
LUW74_37765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW74_37780	COG0667	Aldo Keto reductase
LUW74_37785	COG0003	Pfam Anion-transporting ATPase
LUW74_37845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW74_37850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW74_37865	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_37880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW74_37890	COG0596	Alpha beta hydrolase
LUW74_37900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LUW74_37905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_37980	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW74_37980	COG1672	PFAM Archaeal ATPase
LUW74_37985	COG0277	FAD linked oxidase domain protein
LUW74_38005	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW74_38010	COG2172	sigma factor antagonist activity
LUW74_38015	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LUW74_38040	COG0560	Phosphoserine phosphatase
LUW74_38040	COG3830	Belongs to the UPF0237 family
LUW74_38045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LUW74_38055	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_38065	COG2197	response regulator
LUW74_38090	COG1119	ATPase activity
LUW74_38135	COG2843	Capsule synthesis protein
LUW74_38175	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_38185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW74_38190	COG2188	Transcriptional regulator
LUW74_38195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LUW74_38240	COG1280	lysine exporter protein (LysE YggA)
LUW74_38245	COG1522	sequence-specific DNA binding
LUW74_38255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW74_38255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LUW74_38255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW74_38255	COG3321	synthase
LUW74_38275	COG1819	glycosyl
LUW74_38295	COG1414	Transcriptional regulator
LUW74_38300	COG3339	Conserved Protein
LUW74_38310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LUW74_38330	COG1309	transcriptional regulator
LUW74_38385	COG1595	DNA-templated transcription, initiation
LUW74_38405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW74_38435	COG2205	protein histidine kinase activity
LUW74_38440	COG0745	RESPONSE REGULATOR receiver
LUW74_38485	COG1595	DNA-templated transcription, initiation
LUW74_38515	COG2197	response regulator
LUW74_38535	COG0726	polysaccharide deacetylase
LUW74_38550	COG0477	Major facilitator Superfamily
LUW74_38560	COG2197	response regulator
LUW74_38565	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_38570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_38585	COG0300	oxidoreductase activity
LUW74_38600	COG1309	transcriptional regulator
LUW74_38605	COG2409	Drug exporters of the RND superfamily
LUW74_38610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_38640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LUW74_38655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LUW74_38690	COG1960	acyl-CoA dehydrogenase activity
LUW74_38710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LUW74_38735	COG3795	YCII-related domain
LUW74_38740	COG4941	Belongs to the sigma-70 factor family
LUW74_38760	COG3118	belongs to the thioredoxin family
LUW74_38765	COG3304	Inner membrane component domain
LUW74_38770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LUW74_38805	COG2197	response regulator
LUW74_38810	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LUW74_38900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LUW74_38920	COG0542	response to heat
LUW74_38935	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LUW74_38950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LUW74_38955	COG2151	metal-sulfur cluster biosynthetic enzyme
LUW74_38960	COG3396	Phenylacetate-CoA oxygenase
LUW74_38965	COG3460	Phenylacetate-CoA oxygenase
LUW74_38970	COG3396	Phenylacetate-CoA oxygenase
LUW74_38980	COG1309	transcriptional regulator
LUW74_38985	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW74_39010	COG3401	FG-GAP repeat protein
LUW74_39015	COG3866	Pectate lyase
LUW74_39025	COG0701	Predicted permease
LUW74_39055	COG2885	chlorophyll binding
LUW74_39065	COG1309	transcriptional regulator
LUW74_39090	COG4585	Histidine kinase
LUW74_39095	COG2197	response regulator
LUW74_39110	COG2079	MmgE PrpD family protein
LUW74_39115	COG1609	Transcriptional regulator
LUW74_39120	COG0402	S-adenosylhomocysteine deaminase activity
LUW74_39130	COG3842	ATPase activity
LUW74_39140	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW74_39145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LUW74_39150	COG1063	alcohol dehydrogenase
LUW74_39155	COG0667	Aldo Keto reductase
LUW74_39160	COG1309	transcriptional regulator
LUW74_39165	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LUW74_39170	COG0583	DNA-binding transcription factor activity
LUW74_39185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LUW74_39220	COG0583	DNA-binding transcription factor activity
LUW74_39245	COG0583	DNA-binding transcription factor activity
LUW74_39250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_39255	COG1024	Enoyl-CoA hydratase
LUW74_39310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LUW74_39320	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LUW74_39350	COG3960	tartronate-semialdehyde synthase activity
LUW74_39355	COG2072	flavoprotein involved in K transport
LUW74_39380	COG1177	transmembrane transport
LUW74_39385	COG3842	ATPase activity
LUW74_39405	COG2084	Dehydrogenase
LUW74_39415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LUW74_39435	COG3246	L-lysine catabolic process to acetate
LUW74_39455	COG0477	Major facilitator Superfamily
LUW74_39465	COG3903	Transcriptional regulator
LUW74_39465	COG3629	intracellular signal transduction
LUW74_39470	COG2319	Wd-40 repeat
LUW74_39470	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW74_39490	COG0702	epimerase
LUW74_39530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW74_39545	COG1053	succinate dehydrogenase
LUW74_39545	COG3976	FMN-binding domain protein
LUW74_39550	COG0129	dihydroxy-acid dehydratase activity
LUW74_39585	COG0129	dihydroxy-acid dehydratase activity
LUW74_39590	COG1233	COG1233 Phytoene dehydrogenase and related
LUW74_39600	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_39610	COG2197	response regulator
LUW74_39620	COG0477	Major facilitator Superfamily
LUW74_39640	COG2080	2 iron, 2 sulfur cluster binding
LUW74_39655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW74_39660	COG0640	Transcriptional regulator
LUW74_39665	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_39680	COG3639	organic phosphonate transmembrane transporter activity
LUW74_39685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LUW74_39685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LUW74_39690	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LUW74_39705	COG2814	Major facilitator Superfamily
LUW74_39710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW74_39715	COG0640	Transcriptional regulator
LUW74_39720	COG1846	Transcriptional regulator
LUW74_39725	COG2226	methyltransferase
LUW74_39755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LUW74_39760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LUW74_39785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW74_39805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LUW74_39805	COG1754	DNA topoisomerase type I activity
LUW74_39810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LUW74_39815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LUW74_39820	COG1404	Belongs to the peptidase S8 family
LUW74_39830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LUW74_39845	COG1774	PSP1 C-terminal conserved region
LUW74_39850	COG0656	L-ascorbic acid biosynthetic process
LUW74_39855	COG0477	Major facilitator Superfamily
LUW74_39860	COG3321	synthase
LUW74_39860	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_39860	COG0604	alcohol dehydrogenase
LUW74_39865	COG0789	Transcriptional regulator
LUW74_39970	COG0791	NLP P60 protein
LUW74_39970	COG3883	PFAM NLP P60 protein
LUW74_39975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LUW74_39980	COG2027	D-alanyl-D-alanine carboxypeptidase
LUW74_39990	COG0037	tRNA processing
LUW74_39995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LUW74_40005	COG0302	gtp cyclohydrolase
LUW74_40020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LUW74_40025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LUW74_40045	COG0649	NAD binding
LUW74_40070	COG2124	cytochrome p450
LUW74_40080	COG4585	Histidine kinase
LUW74_40085	COG2197	response regulator
LUW74_40095	COG1136	(ABC) transporter
LUW74_40100	COG0577	efflux transmembrane transporter activity
LUW74_40110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LUW74_40115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LUW74_40130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LUW74_40140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LUW74_40145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LUW74_40155	COG1609	Transcriptional regulator
LUW74_40170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LUW74_40200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LUW74_40205	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LUW74_40205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW74_40215	COG5434	Belongs to the glycosyl hydrolase 28 family
LUW74_40220	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LUW74_40225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LUW74_40240	COG1082	Xylose isomerase domain protein TIM barrel
LUW74_40265	COG1316	TRANSCRIPTIONal
LUW74_40270	COG0506	proline dehydrogenase activity
LUW74_40275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LUW74_40285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LUW74_40290	COG1136	(ABC) transporter
LUW74_40295	COG1136	(ABC) transporter
LUW74_40295	COG0577	efflux transmembrane transporter activity
LUW74_40310	COG0123	including yeast histone deacetylase and acetoin utilization protein
LUW74_40360	COG2814	Major facilitator Superfamily
LUW74_40370	COG2124	cytochrome p450
LUW74_40380	COG0789	Transcriptional regulator
LUW74_40445	COG0560	Phosphoserine phosphatase
LUW74_40480	COG0181	hydroxymethylbilane synthase activity
LUW74_40490	COG0113	porphobilinogen synthase activity
LUW74_40510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LUW74_40515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LUW74_40535	COG0406	alpha-ribazole phosphatase activity
LUW74_40545	COG0785	Cytochrome C biogenesis protein
LUW74_40550	COG1333	cytochrome c biogenesis protein
LUW74_40555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LUW74_40585	COG2226	methyltransferase
LUW74_40600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW74_40610	COG0649	NAD binding
LUW74_40625	COG1034	ATP synthesis coupled electron transport
LUW74_40630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LUW74_40635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW74_40650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW74_40665	COG0142	geranyltranstransferase activity
LUW74_40685	COG5002	protein histidine kinase activity
LUW74_40730	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_40800	COG1013	pyruvate-flavodoxin oxidoreductase activity
LUW74_40805	COG0674	pyruvate-flavodoxin oxidoreductase activity
LUW74_40805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LUW74_40820	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW74_40830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW74_40835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LUW74_40845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW74_40850	COG0839	Belongs to the complex I subunit 6 family
LUW74_40855	COG0713	ATP synthesis coupled electron transport
LUW74_40870	COG1007	ATP synthesis coupled electron transport
LUW74_40875	COG0501	Belongs to the peptidase M48B family
LUW74_40880	COG1666	GTP binding
LUW74_40920	COG1674	ftsk spoiiie
LUW74_40950	COG0019	diaminopimelate decarboxylase activity
LUW74_40980	COG1132	(ABC) transporter
LUW74_41000	COG0681	Belongs to the peptidase S26 family
LUW74_41020	COG1595	DNA-templated transcription, initiation
LUW74_41075	COG1960	acyl-CoA dehydrogenase activity
LUW74_41090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LUW74_41095	COG2030	dehydratase
LUW74_41105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LUW74_41110	COG2119	membrane
LUW74_41115	COG1802	Transcriptional regulator
LUW74_41125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LUW74_41135	COG1595	DNA-templated transcription, initiation
LUW74_41145	COG0436	Aminotransferase
LUW74_41155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LUW74_41165	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LUW74_41170	COG0081	regulation of translation
LUW74_41190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LUW74_41195	COG0222	ribosome binding
LUW74_41210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW74_41215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW74_41260	COG0085	RNA polymerase activity
LUW74_41265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LUW74_41275	COG0346	lactoylglutathione lyase activity
LUW74_41315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW74_41340	COG1522	sequence-specific DNA binding
LUW74_41345	COG0667	Aldo Keto reductase
LUW74_41360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LUW74_41365	COG0049	tRNA binding
LUW74_41370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LUW74_41375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LUW74_41380	COG0051	transcription antitermination factor activity, RNA binding
LUW74_41385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LUW74_41390	COG0088	Forms part of the polypeptide exit tunnel
LUW74_41400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LUW74_41405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LUW74_41410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LUW74_41415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LUW74_41420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LUW74_41425	COG0255	Belongs to the universal ribosomal protein uL29 family
LUW74_41430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LUW74_41440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LUW74_41450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LUW74_41455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LUW74_41460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LUW74_41465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LUW74_41470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LUW74_41480	COG0200	Binds to the 23S rRNA
LUW74_41485	COG0201	protein transport
LUW74_41490	COG0563	adenylate kinase activity
LUW74_41505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LUW74_41515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LUW74_41520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LUW74_41525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LUW74_41530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LUW74_41535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LUW74_41540	COG0202	RNA polymerase activity
LUW74_41545	COG0203	ribosomal protein L17
LUW74_41550	COG0101	tRNA pseudouridine synthase activity
LUW74_41565	COG2340	Cysteine-rich secretory protein family
LUW74_41570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LUW74_41575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LUW74_41580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LUW74_41600	COG1131	(ABC) transporter
LUW74_41620	COG2197	response regulator
LUW74_41625	COG4585	Histidine kinase
LUW74_41630	COG2409	Drug exporters of the RND superfamily
LUW74_41635	COG3831	ATPase activity
LUW74_41645	COG1072	(Pantothenic acid kinase))
LUW74_41650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LUW74_41690	COG1063	alcohol dehydrogenase
LUW74_41695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LUW74_41705	COG0802	atpase or kinase
LUW74_41715	COG0456	acetyltransferase
LUW74_41715	COG1214	PFAM Peptidase M22, glycoprotease
LUW74_41725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LUW74_41745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LUW74_41750	COG0459	protein refolding
LUW74_41755	COG1595	DNA-templated transcription, initiation
LUW74_41780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LUW74_41805	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_41850	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LUW74_41855	COG1216	Glycosyl transferase, family 2
LUW74_41860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW74_41865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW74_41870	COG0500	methyltransferase
LUW74_41895	COG0791	NLP P60 protein
LUW74_41895	COG1388	LysM domain
LUW74_41895	COG3103	Sh3 type 3 domain protein
LUW74_41940	COG2197	response regulator
LUW74_41970	COG2376	Dihydroxyacetone kinase
LUW74_41975	COG1461	Dihydroxyacetone kinase
LUW74_41980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW74_41980	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LUW74_41980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LUW74_42030	COG1764	response to oxidative stress
LUW74_42035	COG0641	radical SAM
LUW74_42080	COG2318	DinB family
LUW74_42100	COG0778	Nitroreductase
LUW74_42105	COG5650	phosphatidylinositol metabolic process
LUW74_42110	COG4585	Histidine kinase
LUW74_42115	COG2197	response regulator
LUW74_42145	COG0180	Tryptophanyl-tRNA synthetase
LUW74_42170	COG0504	CTP synthase activity
LUW74_42190	COG3384	dioxygenase
LUW74_42200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LUW74_42225	COG0438	transferase activity, transferring glycosyl groups
LUW74_42235	COG0588	phosphoglycerate mutase activity
LUW74_42245	COG2814	Major facilitator Superfamily
LUW74_42270	COG0745	RESPONSE REGULATOR receiver
LUW74_42290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LUW74_42295	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_42320	COG4941	Belongs to the sigma-70 factor family
LUW74_42330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LUW74_42335	COG4941	Belongs to the sigma-70 factor family
LUW74_42360	COG1733	regulation of RNA biosynthetic process
LUW74_42375	COG1917	Cupin 2, conserved barrel domain protein
LUW74_42375	COG4977	sequence-specific DNA binding
LUW74_42400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LUW74_42425	COG0477	Major facilitator Superfamily
LUW74_42445	COG1404	Belongs to the peptidase S8 family
LUW74_42475	COG1695	Transcriptional regulator
LUW74_42485	COG1595	DNA-templated transcription, initiation
LUW74_42500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LUW74_42530	COG0459	protein refolding
LUW74_42565	COG1061	Type III restriction enzyme res subunit
LUW74_42580	COG1309	transcriptional regulator
LUW74_42610	COG2814	Major facilitator Superfamily
LUW74_42640	COG2814	Major facilitator Superfamily
LUW74_42645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LUW74_42690	COG0259	pyridoxamine-phosphate oxidase activity
LUW74_42700	COG1573	uracil-dna glycosylase
LUW74_42720	COG2226	methyltransferase
LUW74_42740	COG0183	Belongs to the thiolase family
LUW74_42745	COG1024	Enoyl-CoA hydratase
LUW74_42775	COG0640	Transcriptional regulator
LUW74_42815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LUW74_42825	COG2197	response regulator
LUW74_42855	COG2207	Transcriptional regulator
LUW74_42865	COG4585	Histidine kinase
LUW74_42915	COG1309	transcriptional regulator
LUW74_42935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_42950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW74_42965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW74_42990	COG1725	Transcriptional regulator
LUW74_43005	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_43025	COG0018	arginyl-trna synthetase
LUW74_43030	COG0416	fatty acid biosynthetic process
LUW74_43070	COG1881	PFAM PEBP family protein
LUW74_43075	COG0395	ABC-type sugar transport system, permease component
LUW74_43080	COG1175	transmembrane transport
LUW74_43085	COG3842	ATPase activity
LUW74_43095	COG1134	teichoic acid transport
LUW74_43095	COG1388	LysM domain
LUW74_43105	COG1597	lipid kinase activity
LUW74_43115	COG2720	vancomycin resistance protein
LUW74_43155	COG0438	transferase activity, transferring glycosyl groups
LUW74_43160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LUW74_43175	COG0181	hydroxymethylbilane synthase activity
LUW74_43200	COG0488	(ABC) transporter
LUW74_43205	COG0442	prolyl-tRNA aminoacylation
LUW74_43210	COG0442	prolyl-tRNA aminoacylation
LUW74_43240	COG1595	DNA-templated transcription, initiation
LUW74_43260	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW74_43260	COG2172	sigma factor antagonist activity
LUW74_43260	COG2208	phosphoserine phosphatase activity
LUW74_43295	COG0612	Peptidase, M16
LUW74_43300	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW74_43375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LUW74_43380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_43385	COG4941	Belongs to the sigma-70 factor family
LUW74_43425	COG0577	efflux transmembrane transporter activity
LUW74_43425	COG1136	(ABC) transporter
LUW74_43445	COG5564	TIM-barrel signal transduction protein
LUW74_43465	COG1252	NADH dehydrogenase
LUW74_43470	COG1595	DNA-templated transcription, initiation
LUW74_43480	COG3012	SEC-C Motif Domain Protein
LUW74_43505	COG4941	Belongs to the sigma-70 factor family
LUW74_43515	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LUW74_43520	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LUW74_43525	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LUW74_43555	COG1309	transcriptional regulator
LUW74_43570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LUW74_43575	COG0747	negative chemotaxis
LUW74_43585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW74_43590	COG0444	Belongs to the ABC transporter superfamily
LUW74_43595	COG4608	Belongs to the ABC transporter superfamily
LUW74_43600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LUW74_43605	COG1414	Transcriptional regulator
LUW74_43610	COG2080	2 iron, 2 sulfur cluster binding
LUW74_43615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LUW74_43620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW74_43635	COG3384	dioxygenase
LUW74_43650	COG0579	oxidoreductase
LUW74_43660	COG1396	sequence-specific DNA binding
LUW74_43665	COG0477	Major facilitator Superfamily
LUW74_43670	COG1228	amidohydrolase
LUW74_43685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW74_43685	COG0515	serine threonine protein kinase
LUW74_43730	COG3344	reverse transcriptase
LUW74_43740	COG0714	Associated with various cellular activities
LUW74_43865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW74_43870	COG0195	Participates in both transcription termination and antitermination
LUW74_43905	COG1876	peptidase activity
LUW74_43910	COG1970	mechanosensitive ion channel activity
LUW74_43925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LUW74_43930	COG2409	Drug exporters of the RND superfamily
LUW74_43940	COG3263	regulation of cellular component size
LUW74_43950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LUW74_43955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LUW74_43965	COG0315	cyclic pyranopterin monophosphate synthase activity
LUW74_43970	COG0521	Mo-molybdopterin cofactor biosynthetic process
LUW74_43975	COG0215	cysteine-tRNA ligase activity
LUW74_43990	COG0477	Major facilitator Superfamily
LUW74_43995	COG3795	YCII-related domain
LUW74_44010	COG2222	sugar isomerase
LUW74_44045	COG0154	amidase activity
LUW74_44070	COG1349	DNA-binding transcription factor activity
LUW74_44090	COG0745	RESPONSE REGULATOR receiver
LUW74_44095	COG2205	protein histidine kinase activity
LUW74_44120	COG1960	acyl-CoA dehydrogenase activity
LUW74_44125	COG0667	Aldo Keto reductase
LUW74_44145	COG0375	protein maturation
LUW74_44155	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LUW74_44195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LUW74_44205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LUW74_44230	COG1672	PFAM Archaeal ATPase
LUW74_44230	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW74_44250	COG2508	Transcriptional regulator
LUW74_44265	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_44270	COG0300	oxidoreductase activity
LUW74_44275	COG3835	regulator
LUW74_44300	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LUW74_44310	COG1657	PFAM Prenyltransferase squalene oxidase
LUW74_44330	COG1132	(ABC) transporter
LUW74_44335	COG1132	(ABC) transporter
LUW74_44350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW74_44360	COG0248	Ppx GppA phosphatase
LUW74_44365	COG0701	Predicted permease
LUW74_44390	COG3485	protocatechuate 3,4-dioxygenase
LUW74_44405	COG0778	Nitroreductase
LUW74_44425	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW74_44440	COG1063	alcohol dehydrogenase
LUW74_44445	COG1414	Transcriptional regulator
LUW74_44455	COG1024	Enoyl-CoA hydratase
LUW74_44465	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_44470	COG0402	S-adenosylhomocysteine deaminase activity
LUW74_44490	COG3181	Tripartite tricarboxylate transporter family receptor
LUW74_44500	COG0028	Belongs to the TPP enzyme family
LUW74_44505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LUW74_44520	COG2234	aminopeptidase activity
LUW74_44535	COG0667	Aldo Keto reductase
LUW74_44550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW74_44580	COG0515	serine threonine protein kinase
LUW74_44580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW74_44655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LUW74_44660	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW74_44665	COG0022	dehydrogenase e1 component
LUW74_44680	COG1522	sequence-specific DNA binding
LUW74_44690	COG1802	Transcriptional regulator
LUW74_44700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW74_44710	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_44745	COG1473	amidohydrolase
LUW74_44760	COG0745	RESPONSE REGULATOR receiver
LUW74_44765	COG0018	arginyl-trna synthetase
LUW74_44770	COG0019	diaminopimelate decarboxylase activity
LUW74_44775	COG0460	homoserine dehydrogenase
LUW74_44780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LUW74_44785	COG0083	homoserine kinase activity
LUW74_44800	COG2197	response regulator
LUW74_44805	COG0254	rRNA binding
LUW74_44810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LUW74_44815	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW74_44835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LUW74_44855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LUW74_44860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LUW74_44865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LUW74_44870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LUW74_44875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LUW74_44880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LUW74_44885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LUW74_44925	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_44945	COG0702	epimerase
LUW74_44955	COG1994	Peptidase M50
LUW74_45000	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LUW74_45020	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW74_45050	COG0346	lactoylglutathione lyase activity
LUW74_45055	COG0183	Belongs to the thiolase family
LUW74_45070	COG2814	Major facilitator Superfamily
LUW74_45105	COG1678	Uncharacterized ACR, COG1678
LUW74_45125	COG3265	gluconokinase activity
LUW74_45130	COG1335	isochorismatase
LUW74_45140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LUW74_45185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LUW74_45190	COG1234	tRNA 3'-trailer cleavage
LUW74_45195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LUW74_45200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LUW74_45210	COG1595	DNA-templated transcription, initiation
LUW74_45240	COG0477	Major facilitator Superfamily
LUW74_45265	COG1486	melibiose metabolic process
LUW74_45295	COG0277	FAD linked oxidase domain protein
LUW74_45305	COG3290	protein histidine kinase activity
LUW74_45310	COG3290	protein histidine kinase activity
LUW74_45315	COG4565	transcriptional regulatory protein
LUW74_45325	COG0183	Belongs to the thiolase family
LUW74_45355	COG1280	lysine exporter protein (LysE YggA)
LUW74_45390	COG1760	l-serine dehydratase
LUW74_45395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LUW74_45400	COG0509	glycine decarboxylation via glycine cleavage system
LUW74_45405	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LUW74_45410	COG0750	zinc metalloprotease
LUW74_45415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LUW74_45425	COG1793	dna ligase
LUW74_45450	COG1309	transcriptional regulator
LUW74_45465	COG1309	transcriptional regulator
LUW74_45485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW74_45585	COG1309	transcriptional regulator
LUW74_45605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW74_45650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LUW74_45675	COG0204	Acyl-transferase
LUW74_45685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LUW74_45700	COG3634	alkyl hydroperoxide reductase activity
LUW74_45720	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LUW74_45720	COG2508	Transcriptional regulator
LUW74_45725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LUW74_45765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW74_45770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW74_45770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW74_45785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LUW74_45855	COG1116	anion transmembrane transporter activity
LUW74_45865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW74_45870	COG1609	Transcriptional regulator
LUW74_45930	COG2080	2 iron, 2 sulfur cluster binding
LUW74_45935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LUW74_45940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW74_45945	COG1620	l-lactate permease
LUW74_45990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LUW74_46000	COG1053	succinate dehydrogenase
LUW74_46015	COG0346	lactoylglutathione lyase activity
LUW74_46035	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_46095	COG1960	acyl-CoA dehydrogenase activity
LUW74_46100	COG0583	DNA-binding transcription factor activity
LUW74_46115	COG1309	transcriptional regulator
LUW74_46195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW74_46195	COG0515	serine threonine protein kinase
LUW74_46210	COG0028	Belongs to the TPP enzyme family
LUW74_46225	COG1414	Transcriptional regulator
LUW74_46230	COG3321	synthase
LUW74_46230	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_46230	COG0604	alcohol dehydrogenase
LUW74_46255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LUW74_46280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LUW74_46290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LUW74_46300	COG4208	sulfate ABC transporter
LUW74_46310	COG1959	2 iron, 2 sulfur cluster binding
LUW74_46315	COG1595	DNA-templated transcription, initiation
LUW74_46335	COG0438	transferase activity, transferring glycosyl groups
LUW74_46340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_46425	COG2267	carboxylic ester hydrolase activity
LUW74_46470	COG2171	N-acyltransferase activity
LUW74_46480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW74_46485	COG1611	Belongs to the LOG family
LUW74_46495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LUW74_46500	COG1609	Transcriptional regulator
LUW74_46505	COG0583	DNA-binding transcription factor activity
LUW74_46515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW74_46520	COG1309	transcriptional regulator
LUW74_46525	COG1131	(ABC) transporter
LUW74_46530	COG3559	Exporter of polyketide antibiotics
LUW74_46535	COG3559	Exporter of polyketide antibiotics
LUW74_46540	COG1611	Belongs to the LOG family
LUW74_46545	COG0028	Belongs to the TPP enzyme family
LUW74_46550	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_46555	COG0483	inositol monophosphate 1-phosphatase activity
LUW74_46580	COG2818	Glycosylase
LUW74_46595	COG1024	Enoyl-CoA hydratase
LUW74_46605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LUW74_46615	COG4122	O-methyltransferase activity
LUW74_46635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW74_46650	COG1846	Transcriptional regulator
LUW74_46660	COG2239	Acts as a magnesium transporter
LUW74_46695	COG0613	PHP domain protein
LUW74_46750	COG4585	Histidine kinase
LUW74_46760	COG2409	Drug exporters of the RND superfamily
LUW74_46800	COG3321	synthase
LUW74_46800	COG0604	alcohol dehydrogenase
LUW74_46825	COG0702	epimerase
LUW74_46840	COG0513	Belongs to the DEAD box helicase family
LUW74_46870	COG1793	dna ligase
LUW74_46870	COG3285	dna ligase
LUW74_46875	COG1793	dna ligase
LUW74_46875	COG3285	dna ligase
LUW74_46880	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LUW74_46890	COG2409	Drug exporters of the RND superfamily
LUW74_46900	COG5002	protein histidine kinase activity
LUW74_46905	COG0745	RESPONSE REGULATOR receiver
LUW74_46930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW74_46965	COG0210	DNA helicase
LUW74_46970	COG0210	DNA helicase
LUW74_46975	COG2226	methyltransferase
LUW74_46985	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_47000	COG0019	diaminopimelate decarboxylase activity
LUW74_47015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LUW74_47070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LUW74_47125	COG3480	Lon protease (S16) C-terminal proteolytic domain
LUW74_47135	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_47150	COG1012	belongs to the aldehyde dehydrogenase family
LUW74_47175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_47185	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_47190	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_47200	COG0300	oxidoreductase activity
LUW74_47210	COG1309	transcriptional regulator
LUW74_47230	COG0483	inositol monophosphate 1-phosphatase activity
LUW74_47240	COG0277	FAD linked oxidase domain protein
LUW74_47260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LUW74_47280	COG2135	peptidase activity
LUW74_47295	COG1595	DNA-templated transcription, initiation
LUW74_47300	COG5662	AntiSigma factor
LUW74_47310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LUW74_47310	COG2199	diguanylate cyclase activity
LUW74_47315	COG2199	diguanylate cyclase activity
LUW74_47315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LUW74_47370	COG0277	FAD linked oxidase domain protein
LUW74_47375	COG2205	protein histidine kinase activity
LUW74_47380	COG0745	RESPONSE REGULATOR receiver
LUW74_47395	COG0577	efflux transmembrane transporter activity
LUW74_47395	COG1136	(ABC) transporter
LUW74_47400	COG0577	efflux transmembrane transporter activity
LUW74_47400	COG1136	(ABC) transporter
LUW74_47425	COG0515	serine threonine protein kinase
LUW74_47490	COG1201	RNA secondary structure unwinding
LUW74_47495	COG3629	intracellular signal transduction
LUW74_47495	COG3903	Transcriptional regulator
LUW74_47590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW74_47595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LUW74_47620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LUW74_47625	COG0583	DNA-binding transcription factor activity
LUW74_47660	COG2172	sigma factor antagonist activity
LUW74_47690	COG0156	8-amino-7-oxononanoate synthase activity
LUW74_47695	COG2188	Transcriptional regulator
LUW74_47710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LUW74_47715	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LUW74_47735	COG0439	Biotin carboxylase
LUW74_47760	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_47770	COG0657	acetylesterase activity
LUW74_47775	COG2186	Transcriptional regulator
LUW74_47785	COG1175	transmembrane transport
LUW74_47800	COG4948	Mandelate Racemase Muconate Lactonizing
LUW74_47820	COG2945	thiolester hydrolase activity
LUW74_47820	COG0596	Alpha beta hydrolase
LUW74_47845	COG4585	Histidine kinase
LUW74_47855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW74_47860	COG0281	malic enzyme
LUW74_47865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW74_47870	COG0765	amino acid transport
LUW74_47880	COG0604	alcohol dehydrogenase
LUW74_47885	COG1695	Transcriptional regulator
LUW74_47920	COG0435	Glutathione S-transferase
LUW74_47935	COG1028	Short-chain dehydrogenase reductase Sdr
LUW74_47940	COG1024	Enoyl-CoA hydratase
LUW74_47955	COG2018	Roadblock/LC7 domain
LUW74_47975	COG2018	Roadblock/LC7 domain
LUW74_47990	COG1940	carbohydrate kinase activity
LUW74_47995	COG1129	ABC transporter
LUW74_48000	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW74_48005	COG4213	ABC transporter substrate-binding protein
LUW74_48010	COG0673	inositol 2-dehydrogenase activity
LUW74_48075	COG2226	methyltransferase
LUW74_48080	COG0438	transferase activity, transferring glycosyl groups
LUW74_48085	COG2124	cytochrome p450
LUW74_48090	COG2124	cytochrome p450
LUW74_48115	COG2124	cytochrome p450
LUW74_48120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW74_48130	COG2124	cytochrome p450
LUW74_48135	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_48155	COG3835	regulator
LUW74_48190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW74_48195	COG3622	Belongs to the hyi family
LUW74_48200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LUW74_48205	COG4266	Belongs to the allantoicase family
LUW74_48240	COG1309	transcriptional regulator
LUW74_48245	COG0318	PFAM AMP-dependent synthetase and ligase
LUW74_48250	COG1960	acyl-CoA dehydrogenase activity
LUW74_48255	COG1960	acyl-CoA dehydrogenase activity
LUW74_48265	COG0076	glutamate decarboxylase activity
LUW74_48270	COG1309	transcriptional regulator
LUW74_48275	COG0477	Major facilitator Superfamily
LUW74_48290	COG3572	ergothioneine biosynthetic process
LUW74_48295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW74_48300	COG0121	glutamine amidotransferase
LUW74_48305	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LUW74_48315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LUW74_48330	COG1609	Transcriptional regulator
LUW74_48335	COG2986	histidine ammonia-lyase
LUW74_48340	COG0517	IMP dehydrogenase activity
LUW74_48340	COG1125	glycine betaine transport
LUW74_48345	COG1174	glycine betaine transport
LUW74_48350	COG1174	glycine betaine transport
LUW74_48375	COG4106	trans-aconitate 2-methyltransferase activity
LUW74_48390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW74_48405	COG1136	(ABC) transporter
LUW74_48465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW74_48465	COG3320	Male sterility
LUW74_48480	COG2986	histidine ammonia-lyase
LUW74_48485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LUW74_48540	COG1228	amidohydrolase
LUW74_48545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LUW74_48550	COG0616	signal peptide processing
LUW74_48565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position