locus-tag	class	description
LUW76_00055	COG1309	transcriptional regulator
LUW76_00065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LUW76_00115	COG1522	sequence-specific DNA binding
LUW76_00130	COG0477	Major facilitator Superfamily
LUW76_00145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LUW76_00160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW76_00165	COG0583	DNA-binding transcription factor activity
LUW76_00180	COG1376	ErfK ybiS ycfS ynhG family protein
LUW76_00185	COG1376	ErfK ybiS ycfS ynhG family protein
LUW76_00190	COG0438	transferase activity, transferring glycosyl groups
LUW76_00200	COG2205	protein histidine kinase activity
LUW76_00205	COG0745	RESPONSE REGULATOR receiver
LUW76_00220	COG1136	(ABC) transporter
LUW76_00225	COG0577	efflux transmembrane transporter activity
LUW76_00235	COG1070	Carbohydrate kinase
LUW76_00270	COG0395	ABC-type sugar transport system, permease component
LUW76_00285	COG2851	Citrate transporter
LUW76_00300	COG5297	Belongs to the glycosyl hydrolase family 6
LUW76_00315	COG5297	Belongs to the glycosyl hydrolase family 6
LUW76_00315	COG4733	cellulase activity
LUW76_00330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LUW76_00415	COG3559	Exporter of polyketide antibiotics
LUW76_00420	COG1131	(ABC) transporter
LUW76_00425	COG1309	transcriptional regulator
LUW76_00430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW76_00435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW76_00455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LUW76_00550	COG1169	isochorismate synthase
LUW76_00565	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LUW76_00595	COG1309	transcriptional regulator
LUW76_00615	COG0559	Belongs to the binding-protein-dependent transport system permease family
LUW76_00625	COG1349	DNA-binding transcription factor activity
LUW76_00630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW76_00645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW76_00645	COG2213	PTS system mannitol-specific
LUW76_00665	COG0697	spore germination
LUW76_00715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW76_00730	COG1960	acyl-CoA dehydrogenase activity
LUW76_00770	COG0673	inositol 2-dehydrogenase activity
LUW76_00830	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_00855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_00860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_00870	COG3290	protein histidine kinase activity
LUW76_00885	COG1131	(ABC) transporter
LUW76_00915	COG1215	transferase activity, transferring glycosyl groups
LUW76_00920	COG1960	acyl-CoA dehydrogenase activity
LUW76_00935	COG4585	Histidine kinase
LUW76_00940	COG2197	response regulator
LUW76_00945	COG1309	transcriptional regulator
LUW76_00950	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_00955	COG2272	Belongs to the type-B carboxylesterase lipase family
LUW76_00965	COG2197	response regulator
LUW76_01005	COG0395	ABC-type sugar transport system, permease component
LUW76_01010	COG0252	asparaginase activity
LUW76_01030	COG1902	pentaerythritol trinitrate reductase activity
LUW76_01035	COG3665	Urea carboxylase-associated protein
LUW76_01040	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_01045	COG1595	DNA-templated transcription, initiation
LUW76_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW76_01085	COG1309	transcriptional regulator
LUW76_01095	COG1309	transcriptional regulator
LUW76_01100	COG4608	Belongs to the ABC transporter superfamily
LUW76_01105	COG0444	Belongs to the ABC transporter superfamily
LUW76_01115	COG0601	transmembrane transport
LUW76_01155	COG0346	lactoylglutathione lyase activity
LUW76_01200	COG0243	molybdopterin cofactor binding
LUW76_01235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LUW76_01240	COG0657	acetylesterase activity
LUW76_01245	COG1024	Enoyl-CoA hydratase
LUW76_01255	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_01260	COG0477	Major facilitator Superfamily
LUW76_01275	COG1690	Belongs to the RtcB family
LUW76_01285	COG1940	carbohydrate kinase activity
LUW76_01290	COG1653	transport
LUW76_01295	COG1175	transmembrane transport
LUW76_01300	COG0395	ABC-type sugar transport system, permease component
LUW76_01305	COG2723	6-phospho-beta-galactosidase activity
LUW76_01315	COG1137	ATPase activity
LUW76_01325	COG3973	AAA domain
LUW76_01345	COG1960	acyl-CoA dehydrogenase activity
LUW76_01350	COG1960	acyl-CoA dehydrogenase activity
LUW76_01355	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LUW76_01360	COG0563	adenylate kinase activity
LUW76_01370	COG3608	succinylglutamate desuccinylase aspartoacylase
LUW76_01370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LUW76_01380	COG3629	intracellular signal transduction
LUW76_01380	COG3903	Transcriptional regulator
LUW76_01395	COG3485	protocatechuate 3,4-dioxygenase
LUW76_01400	COG3485	protocatechuate 3,4-dioxygenase
LUW76_01405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LUW76_01415	COG1414	Transcriptional regulator
LUW76_01430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LUW76_01430	COG0189	ligase activity
LUW76_01445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LUW76_01460	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LUW76_01475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LUW76_01495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LUW76_01500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LUW76_01520	COG0859	PFAM glycosyl transferase family 9
LUW76_01525	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_01530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LUW76_01530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LUW76_01535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LUW76_01540	COG0438	transferase activity, transferring glycosyl groups
LUW76_01550	COG0859	PFAM glycosyl transferase family 9
LUW76_01580	COG0477	Major facilitator Superfamily
LUW76_01595	COG0667	Aldo Keto reductase
LUW76_01610	COG2030	dehydratase
LUW76_01610	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_01615	COG0583	DNA-binding transcription factor activity
LUW76_01630	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_01635	COG0022	dehydrogenase e1 component
LUW76_01655	COG0683	leucine binding
LUW76_01660	COG2423	ornithine cyclodeaminase activity
LUW76_01695	COG3938	Belongs to the proline racemase family
LUW76_01720	COG0166	Belongs to the GPI family
LUW76_01735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW76_01775	COG0702	epimerase
LUW76_01795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LUW76_01805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LUW76_01820	COG4585	Histidine kinase
LUW76_01830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LUW76_01835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW76_01840	COG1280	lysine exporter protein (LysE YggA)
LUW76_01850	COG3879	Bacterial protein of unknown function (DUF881)
LUW76_01915	COG0247	lactate metabolic process
LUW76_01920	COG1139	Iron-sulfur cluster binding protein
LUW76_01925	COG1556	Lactate utilization protein
LUW76_01945	COG2223	nitrite transmembrane transporter activity
LUW76_02000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW76_02015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LUW76_02025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LUW76_02035	COG2365	Tyrosine phosphatase family
LUW76_02075	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_02085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW76_02090	COG4977	sequence-specific DNA binding
LUW76_02095	COG2249	NAD(P)H dehydrogenase (quinone) activity
LUW76_02105	COG1649	PFAM Uncharacterised BCR, COG1649
LUW76_02115	COG1733	regulation of RNA biosynthetic process
LUW76_02210	COG0085	RNA polymerase activity
LUW76_02245	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW76_02265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_02270	COG1295	ribonuclease BN
LUW76_02285	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_02300	COG0477	Major facilitator Superfamily
LUW76_02305	COG4257	antibiotic catabolic process
LUW76_02340	COG2205	protein histidine kinase activity
LUW76_02350	COG2409	Drug exporters of the RND superfamily
LUW76_02385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW76_02420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LUW76_02445	COG0596	Alpha beta hydrolase
LUW76_02465	COG0583	DNA-binding transcription factor activity
LUW76_02470	COG0477	Major facilitator Superfamily
LUW76_02500	COG1278	Cold shock
LUW76_02535	COG1162	GTPase activity
LUW76_02545	COG0745	RESPONSE REGULATOR receiver
LUW76_02550	COG2205	protein histidine kinase activity
LUW76_02560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LUW76_02565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LUW76_02570	COG2154	pterin-4-alpha-carbinolamine dehydratase
LUW76_02615	COG3467	pyridoxamine 5'-phosphate
LUW76_02620	COG1309	transcriptional regulator
LUW76_02635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW76_02655	COG0583	DNA-binding transcription factor activity
LUW76_02710	COG0583	DNA-binding transcription factor activity
LUW76_02725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW76_02765	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_02785	COG1739	Uncharacterized protein family UPF0029
LUW76_02830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW76_02835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW76_02880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LUW76_02885	COG1595	DNA-templated transcription, initiation
LUW76_02890	COG2197	response regulator
LUW76_02895	COG4585	Histidine kinase
LUW76_02940	COG4974	Belongs to the 'phage' integrase family
LUW76_02980	COG2226	methyltransferase
LUW76_03005	COG1271	oxidase subunit
LUW76_03020	COG4988	ABC transporter
LUW76_03040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW76_03090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_03125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW76_03125	COG2111	Na H antiporter
LUW76_03145	COG2378	regulation of single-species biofilm formation
LUW76_03195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LUW76_03200	COG0657	acetylesterase activity
LUW76_03225	COG0714	Associated with various cellular activities
LUW76_03235	COG2304	oxidoreductase activity
LUW76_03250	COG2813	Specifically methylates the guanine in position
LUW76_03260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LUW76_03265	COG1077	Cell shape determining protein MreB Mrl
LUW76_03290	COG0740	serine-type endopeptidase activity
LUW76_03295	COG0740	serine-type endopeptidase activity
LUW76_03305	COG2197	response regulator
LUW76_03310	COG4585	Histidine kinase
LUW76_03335	COG3030	protein affecting phage T7 exclusion by the F plasmid
LUW76_03340	COG1216	Glycosyl transferase, family 2
LUW76_03350	COG1607	acyl-coa hydrolase
LUW76_03355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LUW76_03360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LUW76_03390	COG0604	alcohol dehydrogenase
LUW76_03395	COG1509	lysine 2,3-aminomutase activity
LUW76_03400	COG2124	cytochrome p450
LUW76_03410	COG1960	acyl-CoA dehydrogenase activity
LUW76_03430	COG1522	sequence-specific DNA binding
LUW76_03445	COG0395	ABC-type sugar transport system, permease component
LUW76_03450	COG1175	transmembrane transport
LUW76_03455	COG1653	transport
LUW76_03470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LUW76_03480	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LUW76_03485	COG5398	heme oxygenase
LUW76_03510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LUW76_03515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LUW76_03525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LUW76_03545	COG0247	lactate metabolic process
LUW76_03545	COG0277	FAD linked oxidase domain protein
LUW76_03555	COG0577	efflux transmembrane transporter activity
LUW76_03555	COG1136	(ABC) transporter
LUW76_03570	COG1131	(ABC) transporter
LUW76_03590	COG0805	protein transport
LUW76_03595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LUW76_03640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LUW76_03645	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LUW76_03660	COG4122	O-methyltransferase activity
LUW76_03665	COG1222	aaa ATPase
LUW76_03685	COG4585	Histidine kinase
LUW76_03690	COG2197	response regulator
LUW76_03695	COG1136	(ABC) transporter
LUW76_03695	COG0577	efflux transmembrane transporter activity
LUW76_03700	COG0577	efflux transmembrane transporter activity
LUW76_03705	COG4608	Belongs to the ABC transporter superfamily
LUW76_03710	COG0444	Belongs to the ABC transporter superfamily
LUW76_03720	COG0747	negative chemotaxis
LUW76_03725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW76_03735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LUW76_03750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LUW76_03755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW76_03755	COG0515	serine threonine protein kinase
LUW76_03760	COG0215	cysteine-tRNA ligase activity
LUW76_03765	COG0601	transmembrane transport
LUW76_03795	COG0598	Magnesium transport protein CorA
LUW76_03805	COG0667	Aldo Keto reductase
LUW76_03825	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_03840	COG3360	Dodecin
LUW76_03880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LUW76_03880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LUW76_03880	COG1703	isobutyryl-CoA mutase activity
LUW76_03920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_03925	COG0477	Major facilitator Superfamily
LUW76_03940	COG0746	molybdenum cofactor guanylyltransferase activity
LUW76_03945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LUW76_03950	COG2267	carboxylic ester hydrolase activity
LUW76_03955	COG1690	Belongs to the RtcB family
LUW76_03965	COG0477	Major facilitator Superfamily
LUW76_03980	COG0709	Synthesizes selenophosphate from selenide and ATP
LUW76_04000	COG2860	membrane
LUW76_04005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LUW76_04025	COG0516	GMP reductase activity
LUW76_04025	COG0517	IMP dehydrogenase activity
LUW76_04035	COG2364	Membrane
LUW76_04050	COG1619	proteins homologs of microcin C7 resistance protein MccF
LUW76_04055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LUW76_04065	COG1132	(ABC) transporter
LUW76_04075	COG1024	Enoyl-CoA hydratase
LUW76_04085	COG0488	(ABC) transporter
LUW76_04135	COG2151	metal-sulfur cluster biosynthetic enzyme
LUW76_04140	COG0822	iron-sulfur transferase activity
LUW76_04150	COG0396	ATPase activity
LUW76_04175	COG0549	Belongs to the carbamate kinase family
LUW76_04180	COG1131	(ABC) transporter
LUW76_04195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LUW76_04200	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LUW76_04200	COG1796	DNA polymerase
LUW76_04220	COG0109	protoheme IX farnesyltransferase activity
LUW76_04230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LUW76_04240	COG0166	Belongs to the GPI family
LUW76_04260	COG0363	glucosamine-6-phosphate deaminase activity
LUW76_04265	COG1376	ErfK ybiS ycfS ynhG family protein
LUW76_04290	COG0477	Major facilitator Superfamily
LUW76_04315	COG2197	response regulator
LUW76_04320	COG0477	Major facilitator Superfamily
LUW76_04340	COG1695	Transcriptional regulator
LUW76_04350	COG4585	Histidine kinase
LUW76_04355	COG2197	response regulator
LUW76_04365	COG2409	Drug exporters of the RND superfamily
LUW76_04370	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_04395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW76_04400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LUW76_04435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LUW76_04450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_04450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_04460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LUW76_04475	COG1522	sequence-specific DNA binding
LUW76_04490	COG2367	Beta-lactamase
LUW76_04500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LUW76_04505	COG0149	triose-phosphate isomerase activity
LUW76_04510	COG0126	phosphoglycerate kinase activity
LUW76_04515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LUW76_04535	COG1481	regulation of sporulation
LUW76_04540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LUW76_04545	COG1660	Displays ATPase and GTPase activities
LUW76_04550	COG0322	excinuclease ABC activity
LUW76_04570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW76_04575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_04590	COG3903	Transcriptional regulator
LUW76_04590	COG3629	intracellular signal transduction
LUW76_04605	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LUW76_04620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_04635	COG2814	Major facilitator Superfamily
LUW76_04645	COG0542	response to heat
LUW76_04660	COG1960	acyl-CoA dehydrogenase activity
LUW76_04695	COG0497	DNA recombination
LUW76_04720	COG0647	UMP catabolic process
LUW76_04780	COG1024	Enoyl-CoA hydratase
LUW76_04805	COG0406	alpha-ribazole phosphatase activity
LUW76_04810	COG1070	Carbohydrate kinase
LUW76_04820	COG4214	carbohydrate transport
LUW76_04830	COG4213	ABC transporter substrate-binding protein
LUW76_04835	COG1349	DNA-binding transcription factor activity
LUW76_04850	COG0431	NADPH-dependent FMN reductase
LUW76_04860	COG0673	inositol 2-dehydrogenase activity
LUW76_04865	COG0596	Alpha beta hydrolase
LUW76_04895	COG3903	Transcriptional regulator
LUW76_04895	COG3629	intracellular signal transduction
LUW76_04900	COG0247	lactate metabolic process
LUW76_04900	COG0277	FAD linked oxidase domain protein
LUW76_04905	COG1414	Transcriptional regulator
LUW76_04910	COG3971	2-oxopent-4-enoate hydratase activity
LUW76_04955	COG0137	argininosuccinate synthase activity
LUW76_04960	COG1742	UPF0060 membrane protein
LUW76_04985	COG1136	(ABC) transporter
LUW76_04985	COG0577	efflux transmembrane transporter activity
LUW76_05005	COG3620	sequence-specific DNA binding
LUW76_05045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LUW76_05060	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_05140	COG2124	cytochrome p450
LUW76_05170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LUW76_05215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_05220	COG0427	acetyl-CoA hydrolase
LUW76_05250	COG4689	acetoacetate decarboxylase
LUW76_05260	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LUW76_05275	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_05280	COG2078	PFAM AMMECR1 domain protein
LUW76_05280	COG3885	ferrous iron binding
LUW76_05290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_05300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LUW76_05305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LUW76_05305	COG0519	Catalyzes the synthesis of GMP from XMP
LUW76_05310	COG0583	DNA-binding transcription factor activity
LUW76_05355	COG0596	Alpha beta hydrolase
LUW76_05370	COG4221	oxidoreductase activity
LUW76_05385	COG2226	methyltransferase
LUW76_05405	COG0477	Major facilitator Superfamily
LUW76_05420	COG3629	intracellular signal transduction
LUW76_05420	COG3903	Transcriptional regulator
LUW76_05435	COG0745	RESPONSE REGULATOR receiver
LUW76_05470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LUW76_05475	COG1116	anion transmembrane transporter activity
LUW76_05480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_05485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_05495	COG1131	(ABC) transporter
LUW76_05515	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_05535	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_05540	COG1024	Enoyl-CoA hydratase
LUW76_05560	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_05570	COG2267	carboxylic ester hydrolase activity
LUW76_05590	COG2124	cytochrome p450
LUW76_05690	COG3842	ATPase activity
LUW76_05740	COG4221	oxidoreductase activity
LUW76_05765	COG2301	Belongs to the HpcH HpaI aldolase family
LUW76_05775	COG1024	Enoyl-CoA hydratase
LUW76_05800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_05835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_05840	COG2072	flavoprotein involved in K transport
LUW76_05845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_05855	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_05860	COG1960	acyl-CoA dehydrogenase activity
LUW76_05865	COG1960	acyl-CoA dehydrogenase activity
LUW76_05870	COG0183	Belongs to the thiolase family
LUW76_05880	COG1024	Enoyl-CoA hydratase
LUW76_05885	COG2186	Transcriptional regulator
LUW76_05895	COG0444	Belongs to the ABC transporter superfamily
LUW76_05900	COG0601	transmembrane transport
LUW76_05955	COG2814	Major facilitator Superfamily
LUW76_05960	COG0583	DNA-binding transcription factor activity
LUW76_05965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_05985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_05995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_06040	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_06070	COG1609	Transcriptional regulator
LUW76_06075	COG1960	acyl-CoA dehydrogenase activity
LUW76_06080	COG0183	Belongs to the thiolase family
LUW76_06100	COG1960	acyl-CoA dehydrogenase activity
LUW76_06110	COG1024	Enoyl-CoA hydratase
LUW76_06120	COG1960	acyl-CoA dehydrogenase activity
LUW76_06130	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_06135	COG0604	alcohol dehydrogenase
LUW76_06135	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_06135	COG3321	synthase
LUW76_06145	COG1024	Enoyl-CoA hydratase
LUW76_06165	COG1024	Enoyl-CoA hydratase
LUW76_06180	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_06195	COG1960	acyl-CoA dehydrogenase activity
LUW76_06205	COG1960	acyl-CoA dehydrogenase activity
LUW76_06210	COG1960	acyl-CoA dehydrogenase activity
LUW76_06220	COG1024	Enoyl-CoA hydratase
LUW76_06225	COG1024	Enoyl-CoA hydratase
LUW76_06230	COG0183	Belongs to the thiolase family
LUW76_06235	COG1024	Enoyl-CoA hydratase
LUW76_06240	COG1960	acyl-CoA dehydrogenase activity
LUW76_06250	COG1063	alcohol dehydrogenase
LUW76_06260	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_06265	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_06270	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_06285	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_06325	COG2130	NADP-dependent
LUW76_06330	COG0028	Belongs to the TPP enzyme family
LUW76_06345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_06350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW76_06355	COG1024	Enoyl-CoA hydratase
LUW76_06355	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_06390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LUW76_06410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LUW76_06445	COG0582	viral genome integration into host DNA
LUW76_06500	COG0383	alpha-mannosidase activity
LUW76_06510	COG3842	ATPase activity
LUW76_06515	COG2011	ABC-type metal ion transport system permease component
LUW76_06525	COG2182	Extracellular solute-binding protein
LUW76_06530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LUW76_06535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LUW76_06540	COG0640	Transcriptional regulator
LUW76_06560	COG3250	beta-galactosidase activity
LUW76_06580	COG0395	ABC-type sugar transport system, permease component
LUW76_06610	COG1940	carbohydrate kinase activity
LUW76_06625	COG4214	carbohydrate transport
LUW76_06630	COG4213	ABC transporter substrate-binding protein
LUW76_06635	COG3629	intracellular signal transduction
LUW76_06655	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_06660	COG1129	ABC transporter
LUW76_06675	COG0434	BtpA family
LUW76_06680	COG1609	Transcriptional regulator
LUW76_06715	COG2018	Roadblock/LC7 domain
LUW76_06755	COG1396	sequence-specific DNA binding
LUW76_06760	COG0740	serine-type endopeptidase activity
LUW76_06765	COG0740	serine-type endopeptidase activity
LUW76_06815	COG1486	melibiose metabolic process
LUW76_06830	COG2182	Extracellular solute-binding protein
LUW76_06835	COG1175	transmembrane transport
LUW76_06840	COG0395	ABC-type sugar transport system, permease component
LUW76_06850	COG1105	Belongs to the carbohydrate kinase PfkB family
LUW76_06880	COG1595	DNA-templated transcription, initiation
LUW76_06900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LUW76_06955	COG1960	acyl-CoA dehydrogenase activity
LUW76_06965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_06970	COG0740	serine-type endopeptidase activity
LUW76_06975	COG1414	Transcriptional regulator
LUW76_06985	COG2124	cytochrome p450
LUW76_07015	COG0437	4 iron, 4 sulfur cluster binding
LUW76_07030	COG1946	Acyl-CoA thioesterase
LUW76_07040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW76_07055	COG1280	lysine exporter protein (LysE YggA)
LUW76_07080	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_07090	COG3842	ATPase activity
LUW76_07100	COG1609	Transcriptional regulator
LUW76_07120	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LUW76_07135	COG0431	NADPH-dependent FMN reductase
LUW76_07155	COG2353	YceI-like domain
LUW76_07190	COG2186	Transcriptional regulator
LUW76_07195	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_07215	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_07300	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LUW76_07305	COG1797	cobyrinic acid a,c-diamide synthase activity
LUW76_07365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LUW76_07370	COG1968	undecaprenyl-diphosphatase activity
LUW76_07390	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_07395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_07425	COG1414	Transcriptional regulator
LUW76_07440	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_07450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW76_07480	COG1940	carbohydrate kinase activity
LUW76_07480	COG1846	Transcriptional regulator
LUW76_07485	COG1126	abc transporter atp-binding protein
LUW76_07495	COG0765	amino acid transport
LUW76_07500	COG0765	amino acid transport
LUW76_07510	COG3142	Participates in the control of copper homeostasis
LUW76_07520	COG0366	Alpha amylase catalytic
LUW76_07535	COG0366	Alpha amylase catalytic
LUW76_07540	COG3281	Trehalose synthase
LUW76_07545	COG0667	Aldo Keto reductase
LUW76_07555	COG3842	ATPase activity
LUW76_07565	COG1077	Cell shape determining protein MreB Mrl
LUW76_07580	COG4715	Zinc finger, swim domain protein
LUW76_07585	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LUW76_07590	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LUW76_07610	COG0626	cystathionine gamma-synthase activity
LUW76_07635	COG0446	pyridine nucleotide-disulphide oxidoreductase
LUW76_07645	COG0174	glutamine synthetase
LUW76_07670	COG0747	negative chemotaxis
LUW76_07695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LUW76_07710	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LUW76_07710	COG0235	Class ii aldolase
LUW76_07720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LUW76_07730	COG0587	DNA-directed DNA polymerase activity
LUW76_07735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW76_07735	COG0515	serine threonine protein kinase
LUW76_07740	COG0823	Involved in the tonB-independent uptake of proteins
LUW76_07745	COG2409	Drug exporters of the RND superfamily
LUW76_07750	COG0248	Ppx GppA phosphatase
LUW76_07760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW76_07770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_07800	COG0656	L-ascorbic acid biosynthetic process
LUW76_07820	COG3250	beta-galactosidase activity
LUW76_07825	COG3250	beta-galactosidase activity
LUW76_07845	COG3250	beta-galactosidase activity
LUW76_07850	COG3250	beta-galactosidase activity
LUW76_07875	COG3347	Dehydrogenase
LUW76_07875	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_07880	COG3250	beta-galactosidase activity
LUW76_07895	COG3254	rhamnose metabolic process
LUW76_07900	COG1879	ABC-type sugar transport system periplasmic component
LUW76_07905	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_07915	COG1129	ABC transporter
LUW76_07920	COG1609	Transcriptional regulator
LUW76_07925	COG0247	lactate metabolic process
LUW76_07930	COG1139	Iron-sulfur cluster binding protein
LUW76_07935	COG1556	Lactate utilization protein
LUW76_07940	COG1070	Carbohydrate kinase
LUW76_07945	COG1672	PFAM Archaeal ATPase
LUW76_07945	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_08015	COG1643	Atp-dependent helicase
LUW76_08045	COG3284	Transcriptional regulator
LUW76_08065	COG0183	Belongs to the thiolase family
LUW76_08105	COG2755	lipolytic protein G-D-S-L family
LUW76_08155	COG3540	Alkaline phosphatase
LUW76_08215	COG0210	DNA helicase
LUW76_08220	COG0515	serine threonine protein kinase
LUW76_08220	COG2815	serine threonine protein kinase
LUW76_08235	COG0328	RNA-DNA hybrid ribonuclease activity
LUW76_08270	COG0601	transmembrane transport
LUW76_08275	COG0444	Belongs to the ABC transporter superfamily
LUW76_08300	COG4948	Mandelate Racemase Muconate Lactonizing
LUW76_08305	COG2508	Transcriptional regulator
LUW76_08305	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LUW76_08315	COG0667	Aldo Keto reductase
LUW76_08340	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LUW76_08350	COG0454	-acetyltransferase
LUW76_08360	COG2197	response regulator
LUW76_08370	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
LUW76_08380	COG0477	Major facilitator Superfamily
LUW76_08385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_08385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_08420	COG1764	response to oxidative stress
LUW76_08425	COG0204	Acyl-transferase
LUW76_08425	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_08450	COG0668	transmembrane transport
LUW76_08475	COG0438	transferase activity, transferring glycosyl groups
LUW76_08485	COG2197	response regulator
LUW76_08540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_08565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LUW76_08580	COG4221	oxidoreductase activity
LUW76_08635	COG1960	acyl-CoA dehydrogenase activity
LUW76_08675	COG0235	Class ii aldolase
LUW76_08680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW76_08685	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_08695	COG0443	Heat shock 70 kDa protein
LUW76_08725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_08730	COG1309	transcriptional regulator
LUW76_08740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW76_08755	COG1309	transcriptional regulator
LUW76_08790	COG2186	Transcriptional regulator
LUW76_08795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW76_08810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_08830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LUW76_08855	COG0714	Associated with various cellular activities
LUW76_08885	COG0714	Associated with various cellular activities
LUW76_08890	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LUW76_08895	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LUW76_08915	COG0640	Transcriptional regulator
LUW76_08925	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LUW76_08940	COG1597	lipid kinase activity
LUW76_08950	COG0667	Aldo Keto reductase
LUW76_08990	COG0300	oxidoreductase activity
LUW76_09005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LUW76_09010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LUW76_09025	COG4948	Mandelate Racemase Muconate Lactonizing
LUW76_09040	COG1175	transmembrane transport
LUW76_09045	COG0395	ABC-type sugar transport system, permease component
LUW76_09055	COG0673	inositol 2-dehydrogenase activity
LUW76_09065	COG0714	Associated with various cellular activities
LUW76_09075	COG2304	oxidoreductase activity
LUW76_09080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW76_09085	COG0745	RESPONSE REGULATOR receiver
LUW76_09090	COG2205	protein histidine kinase activity
LUW76_09115	COG0420	3'-5' exonuclease activity
LUW76_09185	COG3962	Belongs to the TPP enzyme family
LUW76_09190	COG3718	enzyme involved in inositol metabolism
LUW76_09200	COG1082	Xylose isomerase domain protein TIM barrel
LUW76_09205	COG0673	inositol 2-dehydrogenase activity
LUW76_09225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LUW76_09230	COG0604	alcohol dehydrogenase
LUW76_09235	COG1476	TRANSCRIPTIONal
LUW76_09245	COG2814	Major facilitator Superfamily
LUW76_09255	COG0477	Major facilitator Superfamily
LUW76_09260	COG0456	acetyltransferase
LUW76_09260	COG1846	Transcriptional regulator
LUW76_09285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LUW76_09300	COG0386	Belongs to the glutathione peroxidase family
LUW76_09320	COG1316	TRANSCRIPTIONal
LUW76_09355	COG2018	Roadblock/LC7 domain
LUW76_09370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_09375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_09390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_09395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_09400	COG1116	anion transmembrane transporter activity
LUW76_09400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_09440	COG0277	FAD linked oxidase domain protein
LUW76_09490	COG0175	sulfate reduction
LUW76_09510	COG1960	acyl-CoA dehydrogenase activity
LUW76_09535	COG0438	transferase activity, transferring glycosyl groups
LUW76_09545	COG0438	transferase activity, transferring glycosyl groups
LUW76_09575	COG2326	polyphosphate kinase activity
LUW76_09635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LUW76_09640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LUW76_09650	COG1131	(ABC) transporter
LUW76_09665	COG0446	pyridine nucleotide-disulphide oxidoreductase
LUW76_09685	COG0531	amino acid
LUW76_09695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LUW76_09720	COG0516	GMP reductase activity
LUW76_09720	COG0517	IMP dehydrogenase activity
LUW76_09765	COG1063	alcohol dehydrogenase
LUW76_09775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LUW76_09820	COG1063	alcohol dehydrogenase
LUW76_09825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LUW76_09840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW76_09845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_09850	COG1937	Protein conserved in bacteria
LUW76_09880	COG1830	Aldolase
LUW76_09890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LUW76_09900	COG1960	acyl-CoA dehydrogenase activity
LUW76_09910	COG1129	ABC transporter
LUW76_09940	COG0145	ligase activity
LUW76_09955	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_09975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW76_09980	COG0531	amino acid
LUW76_09990	COG1595	DNA-templated transcription, initiation
LUW76_10005	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_10010	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_10015	COG1129	ABC transporter
LUW76_10020	COG1879	ABC-type sugar transport system periplasmic component
LUW76_10035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LUW76_10040	COG1349	DNA-binding transcription factor activity
LUW76_10075	COG1793	dna ligase
LUW76_10080	COG3540	Alkaline phosphatase
LUW76_10090	COG2186	Transcriptional regulator
LUW76_10095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW76_10105	COG2936	dipeptidyl-peptidase activity
LUW76_10120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LUW76_10135	COG3253	May function as heme-dependent peroxidase
LUW76_10150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LUW76_10170	COG0672	)-iron permease
LUW76_10180	COG0577	efflux transmembrane transporter activity
LUW76_10185	COG0577	efflux transmembrane transporter activity
LUW76_10185	COG1136	(ABC) transporter
LUW76_10205	COG0475	glutathione-regulated potassium exporter activity
LUW76_10225	COG3548	integral membrane protein
LUW76_10230	COG0745	RESPONSE REGULATOR receiver
LUW76_10235	COG2205	protein histidine kinase activity
LUW76_10240	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_10245	COG0183	Belongs to the thiolase family
LUW76_10250	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_10250	COG1024	Enoyl-CoA hydratase
LUW76_10255	COG0531	amino acid
LUW76_10270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LUW76_10275	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LUW76_10285	COG1175	transmembrane transport
LUW76_10290	COG0395	ABC-type sugar transport system, permease component
LUW76_10310	COG1280	lysine exporter protein (LysE YggA)
LUW76_10315	COG0667	Aldo Keto reductase
LUW76_10330	COG2197	response regulator
LUW76_10340	COG2409	Drug exporters of the RND superfamily
LUW76_10365	COG0640	Transcriptional regulator
LUW76_10390	COG1562	ergosterol biosynthetic process
LUW76_10440	COG2197	response regulator
LUW76_10450	COG0577	efflux transmembrane transporter activity
LUW76_10455	COG0583	DNA-binding transcription factor activity
LUW76_10470	COG0800	Aldolase
LUW76_10475	COG0837	glucose binding
LUW76_10480	COG0129	dihydroxy-acid dehydratase activity
LUW76_10530	COG2084	Dehydrogenase
LUW76_10565	COG0297	glycogen (starch) synthase activity
LUW76_10585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW76_10585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW76_10590	COG3541	Predicted nucleotidyltransferase
LUW76_10600	COG1653	transport
LUW76_10615	COG0366	Alpha amylase catalytic
LUW76_10635	COG0395	ABC-type sugar transport system, permease component
LUW76_10665	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_10695	COG2814	Major facilitator Superfamily
LUW76_10705	COG1501	Belongs to the glycosyl hydrolase 31 family
LUW76_10710	COG0395	ABC-type sugar transport system, permease component
LUW76_10715	COG1175	transmembrane transport
LUW76_10730	COG4336	lyase activity
LUW76_10735	COG1984	allophanate hydrolase subunit 2
LUW76_10740	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LUW76_10745	COG1914	H( )-stimulated, divalent metal cation uptake system
LUW76_10755	COG1802	Transcriptional regulator
LUW76_10760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LUW76_10765	COG0022	dehydrogenase e1 component
LUW76_10770	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW76_10790	COG1595	DNA-templated transcription, initiation
LUW76_10825	COG1940	carbohydrate kinase activity
LUW76_10830	COG0673	inositol 2-dehydrogenase activity
LUW76_10835	COG1653	transport
LUW76_10865	COG0300	oxidoreductase activity
LUW76_10870	COG0583	DNA-binding transcription factor activity
LUW76_10900	COG1522	sequence-specific DNA binding
LUW76_10910	COG3281	Trehalose synthase
LUW76_10920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LUW76_10925	COG2226	methyltransferase
LUW76_10945	COG0477	Major facilitator Superfamily
LUW76_10965	COG4552	Acetyltransferase involved in intracellular survival and related
LUW76_10970	COG0477	Major facilitator Superfamily
LUW76_10980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LUW76_10985	COG0531	amino acid
LUW76_10990	COG0569	domain protein
LUW76_11010	COG0477	Major facilitator Superfamily
LUW76_11015	COG0728	peptidoglycan biosynthetic process
LUW76_11030	COG1136	(ABC) transporter
LUW76_11040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW76_11050	COG0756	dUTP diphosphatase activity
LUW76_11090	COG0706	membrane insertase activity
LUW76_11100	COG0525	valine-tRNA ligase activity
LUW76_11135	COG2205	protein histidine kinase activity
LUW76_11140	COG0745	RESPONSE REGULATOR receiver
LUW76_11155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LUW76_11195	COG3402	PFAM membrane-flanked domain
LUW76_11220	COG1252	NADH dehydrogenase
LUW76_11225	COG1881	PFAM PEBP family protein
LUW76_11245	COG0288	reversible hydration of carbon dioxide
LUW76_11265	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
LUW76_11280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LUW76_11330	COG0251	oxidation-reduction process
LUW76_11335	COG0583	DNA-binding transcription factor activity
LUW76_11370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LUW76_11400	COG2814	Major facilitator Superfamily
LUW76_11405	COG1846	Transcriptional regulator
LUW76_11445	COG0517	IMP dehydrogenase activity
LUW76_11455	COG0464	growth
LUW76_11460	COG4451	ribulose bisphosphate carboxylase, small
LUW76_11465	COG1850	ribulose-bisphosphate carboxylase activity
LUW76_11470	COG0583	DNA-binding transcription factor activity
LUW76_11480	COG3268	Saccharopine dehydrogenase
LUW76_11490	COG2197	response regulator
LUW76_11495	COG0572	uridine kinase
LUW76_11520	COG0432	Pfam Uncharacterised protein family UPF0047
LUW76_11530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LUW76_11600	COG2378	regulation of single-species biofilm formation
LUW76_11615	COG2267	carboxylic ester hydrolase activity
LUW76_11620	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_11645	COG0410	ABC transporter
LUW76_11670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LUW76_11670	COG1796	DNA polymerase
LUW76_11675	COG4585	Histidine kinase
LUW76_11680	COG2197	response regulator
LUW76_11710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW76_11715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW76_11790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LUW76_11800	COG0514	ATP-dependent DNA helicase (RecQ)
LUW76_11835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LUW76_11865	COG2011	ABC-type metal ion transport system permease component
LUW76_11870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LUW76_11880	COG1309	transcriptional regulator
LUW76_11885	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_11900	COG4585	Histidine kinase
LUW76_11905	COG1131	(ABC) transporter
LUW76_11920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LUW76_11945	COG2197	response regulator
LUW76_11955	COG0187	DNA topoisomerase II activity
LUW76_11960	COG1131	(ABC) transporter
LUW76_11985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW76_12000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LUW76_12035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LUW76_12040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LUW76_12070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LUW76_12135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LUW76_12150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LUW76_12160	COG0495	leucyl-tRNA aminoacylation
LUW76_12170	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_12180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LUW76_12185	COG0596	Alpha beta hydrolase
LUW76_12220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LUW76_12225	COG0277	FAD linked oxidase domain protein
LUW76_12260	COG0577	efflux transmembrane transporter activity
LUW76_12265	COG1136	(ABC) transporter
LUW76_12310	COG1683	Conserved Protein
LUW76_12325	COG1595	DNA-templated transcription, initiation
LUW76_12340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LUW76_12450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_12455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_12500	COG0406	alpha-ribazole phosphatase activity
LUW76_12510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LUW76_12515	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LUW76_12520	COG0501	Belongs to the peptidase M48B family
LUW76_12535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LUW76_12540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LUW76_12545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LUW76_12550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LUW76_12555	COG1530	ribonuclease E activity
LUW76_12570	COG0772	Belongs to the SEDS family
LUW76_12575	COG0768	penicillin binding
LUW76_12590	COG1077	Cell shape determining protein MreB Mrl
LUW76_12595	COG0105	UTP biosynthetic process
LUW76_12610	COG0285	dihydrofolate synthase activity
LUW76_12625	COG0525	valine-tRNA ligase activity
LUW76_12635	COG2197	response regulator
LUW76_12640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LUW76_12645	COG0740	serine-type endopeptidase activity
LUW76_12650	COG0740	serine-type endopeptidase activity
LUW76_12655	COG0544	peptidyl-prolyl cis-trans isomerase activity
LUW76_12665	COG2183	response to ionizing radiation
LUW76_12700	COG1309	transcriptional regulator
LUW76_12720	COG1733	regulation of RNA biosynthetic process
LUW76_12725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LUW76_12790	COG2815	serine threonine protein kinase
LUW76_12790	COG0515	serine threonine protein kinase
LUW76_12875	COG0210	DNA helicase
LUW76_12925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_12930	COG0596	Alpha beta hydrolase
LUW76_13010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LUW76_13030	COG0789	Transcriptional regulator
LUW76_13035	COG3629	intracellular signal transduction
LUW76_13035	COG3903	Transcriptional regulator
LUW76_13060	COG3903	Transcriptional regulator
LUW76_13060	COG3629	intracellular signal transduction
LUW76_13065	COG3903	Transcriptional regulator
LUW76_13065	COG3629	intracellular signal transduction
LUW76_13075	COG2409	Drug exporters of the RND superfamily
LUW76_13125	COG1129	ABC transporter
LUW76_13130	COG4214	carbohydrate transport
LUW76_13135	COG1609	Transcriptional regulator
LUW76_13180	COG0709	Synthesizes selenophosphate from selenide and ATP
LUW76_13225	COG2814	Major facilitator Superfamily
LUW76_13270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_13275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW76_13285	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_13290	COG0657	acetylesterase activity
LUW76_13300	COG4585	Histidine kinase
LUW76_13305	COG2197	response regulator
LUW76_13325	COG5002	protein histidine kinase activity
LUW76_13330	COG0515	serine threonine protein kinase
LUW76_13345	COG0698	ribose 5-phosphate isomerase
LUW76_13375	COG0310	cobalt ion transport
LUW76_13380	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LUW76_13400	COG0154	amidase activity
LUW76_13410	COG0129	dihydroxy-acid dehydratase activity
LUW76_13430	COG1505	serine-type exopeptidase activity
LUW76_13435	COG2226	methyltransferase
LUW76_13460	COG0668	transmembrane transport
LUW76_13470	COG0366	Alpha amylase catalytic
LUW76_13480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_13485	COG0824	Thioesterase
LUW76_13490	COG4948	Mandelate Racemase Muconate Lactonizing
LUW76_13510	COG0629	single-stranded DNA binding
LUW76_13525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LUW76_13525	COG1648	precorrin-2 dehydrogenase activity
LUW76_13530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LUW76_13550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LUW76_13555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_13580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_13595	COG2226	methyltransferase
LUW76_13605	COG4585	Histidine kinase
LUW76_13610	COG2197	response regulator
LUW76_13625	COG0587	DNA-directed DNA polymerase activity
LUW76_13640	COG1309	transcriptional regulator
LUW76_13665	COG0515	serine threonine protein kinase
LUW76_13665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW76_13670	COG1280	lysine exporter protein (LysE YggA)
LUW76_13685	COG1492	cobalamin metabolic process
LUW76_13720	COG1674	ftsk spoiiie
LUW76_13740	COG2188	Transcriptional regulator
LUW76_13780	COG2160	L-arabinose isomerase activity
LUW76_13785	COG1879	ABC-type sugar transport system periplasmic component
LUW76_13790	COG1129	ABC transporter
LUW76_13800	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_13805	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_13845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LUW76_13855	COG1132	(ABC) transporter
LUW76_13895	COG1051	belongs to the nudix hydrolase family
LUW76_13900	COG1414	Transcriptional regulator
LUW76_13910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW76_13915	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_13920	COG1879	ABC-type sugar transport system periplasmic component
LUW76_13925	COG1129	ABC transporter
LUW76_13930	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_13950	COG0436	Aminotransferase
LUW76_13955	COG4977	sequence-specific DNA binding
LUW76_13970	COG4977	sequence-specific DNA binding
LUW76_13980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LUW76_14010	COG0640	Transcriptional regulator
LUW76_14025	COG0154	amidase activity
LUW76_14035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW76_14035	COG3153	acetyltransferase
LUW76_14045	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LUW76_14055	COG3940	Belongs to the glycosyl hydrolase 43 family
LUW76_14075	COG3119	arylsulfatase activity
LUW76_14080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW76_14090	COG1132	(ABC) transporter
LUW76_14095	COG1132	(ABC) transporter
LUW76_14095	COG2375	cellular response to nickel ion
LUW76_14110	COG4585	Histidine kinase
LUW76_14115	COG2197	response regulator
LUW76_14120	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW76_14120	COG2319	Wd-40 repeat
LUW76_14155	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_14205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_14215	COG1595	DNA-templated transcription, initiation
LUW76_14230	COG0596	Alpha beta hydrolase
LUW76_14245	COG3339	Conserved Protein
LUW76_14255	COG4977	sequence-specific DNA binding
LUW76_14260	COG4447	cellulose binding
LUW76_14275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LUW76_14275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LUW76_14280	COG1349	DNA-binding transcription factor activity
LUW76_14290	COG1175	transmembrane transport
LUW76_14295	COG0395	ABC-type sugar transport system, permease component
LUW76_14340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LUW76_14345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW76_14350	COG3629	intracellular signal transduction
LUW76_14360	COG1960	acyl-CoA dehydrogenase activity
LUW76_14370	COG3321	synthase
LUW76_14395	COG0156	8-amino-7-oxononanoate synthase activity
LUW76_14405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_14410	COG0156	8-amino-7-oxononanoate synthase activity
LUW76_14415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW76_14420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW76_14425	COG2197	response regulator
LUW76_14430	COG3469	chitinase activity
LUW76_14490	COG0515	serine threonine protein kinase
LUW76_14490	COG2815	serine threonine protein kinase
LUW76_14540	COG1116	anion transmembrane transporter activity
LUW76_14570	COG3629	intracellular signal transduction
LUW76_14570	COG3903	Transcriptional regulator
LUW76_14610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LUW76_14630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LUW76_14635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LUW76_14675	COG1309	transcriptional regulator
LUW76_14705	COG3468	outer membrane autotransporter barrel domain protein
LUW76_14725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LUW76_14765	COG2226	methyltransferase
LUW76_14780	COG1047	Peptidyl-prolyl cis-trans
LUW76_14785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW76_14855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW76_14865	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LUW76_14875	COG2197	response regulator
LUW76_14930	COG1309	transcriptional regulator
LUW76_14940	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_14945	COG1309	transcriptional regulator
LUW76_14960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LUW76_14970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW76_14980	COG3119	arylsulfatase activity
LUW76_15000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW76_15005	COG0601	transmembrane transport
LUW76_15020	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LUW76_15030	COG1846	Transcriptional regulator
LUW76_15035	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LUW76_15065	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW76_15065	COG2319	Wd-40 repeat
LUW76_15070	COG2409	Drug exporters of the RND superfamily
LUW76_15080	COG1695	Transcriptional regulator
LUW76_15085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LUW76_15095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW76_15110	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_15185	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW76_15200	COG0702	epimerase
LUW76_15215	COG1196	nuclear chromosome segregation
LUW76_15215	COG0741	lytic transglycosylase activity
LUW76_15215	COG0739	heme binding
LUW76_15230	COG0778	Nitroreductase
LUW76_15230	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LUW76_15250	COG3387	PFAM Glycoside hydrolase 15-related
LUW76_15265	COG3629	intracellular signal transduction
LUW76_15265	COG3903	Transcriptional regulator
LUW76_15285	COG3629	intracellular signal transduction
LUW76_15285	COG3903	Transcriptional regulator
LUW76_15315	COG0300	oxidoreductase activity
LUW76_15345	COG0477	Major facilitator Superfamily
LUW76_15395	COG1414	Transcriptional regulator
LUW76_15400	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LUW76_15410	COG4608	Belongs to the ABC transporter superfamily
LUW76_15450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LUW76_15455	COG1960	acyl-CoA dehydrogenase activity
LUW76_15465	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_15510	COG3260	NADH ubiquinone oxidoreductase 20
LUW76_15520	COG0650	Formate hydrogenlyase subunit 4
LUW76_15530	COG0651	ATP synthesis coupled electron transport
LUW76_15535	COG3261	NADH dehydrogenase
LUW76_15535	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LUW76_15545	COG0183	Belongs to the thiolase family
LUW76_15555	COG1960	acyl-CoA dehydrogenase activity
LUW76_15565	COG1960	acyl-CoA dehydrogenase activity
LUW76_15570	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_15585	COG1090	epimerase
LUW76_15595	COG1090	epimerase
LUW76_15600	COG1595	DNA-templated transcription, initiation
LUW76_15605	COG0596	Alpha beta hydrolase
LUW76_15620	COG1309	transcriptional regulator
LUW76_15635	COG2267	carboxylic ester hydrolase activity
LUW76_15665	COG0745	RESPONSE REGULATOR receiver
LUW76_15680	COG1136	(ABC) transporter
LUW76_15680	COG0577	efflux transmembrane transporter activity
LUW76_15685	COG1136	(ABC) transporter
LUW76_15715	COG1960	acyl-CoA dehydrogenase activity
LUW76_15725	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LUW76_15770	COG0726	polysaccharide deacetylase
LUW76_15775	COG1024	Enoyl-CoA hydratase
LUW76_15785	COG1073	alpha beta
LUW76_15785	COG2226	methyltransferase
LUW76_15790	COG0215	cysteine-tRNA ligase activity
LUW76_15820	COG0006	proline dipeptidase activity
LUW76_15830	COG0604	alcohol dehydrogenase
LUW76_15830	COG3321	synthase
LUW76_15840	COG4585	Histidine kinase
LUW76_15890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_15905	COG2255	four-way junction helicase activity
LUW76_15910	COG1674	ftsk spoiiie
LUW76_15930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LUW76_15940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LUW76_15945	COG1316	TRANSCRIPTIONal
LUW76_15965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW76_15985	COG1132	(ABC) transporter
LUW76_15995	COG1132	(ABC) transporter
LUW76_16015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LUW76_16055	COG1846	Transcriptional regulator
LUW76_16075	COG1053	succinate dehydrogenase
LUW76_16105	COG0515	serine threonine protein kinase
LUW76_16110	COG1316	TRANSCRIPTIONal
LUW76_16175	COG0791	NLP P60 protein
LUW76_16175	COG3883	PFAM NLP P60 protein
LUW76_16220	COG2885	chlorophyll binding
LUW76_16235	COG4585	Histidine kinase
LUW76_16260	COG2894	cell division
LUW76_16285	COG0542	response to heat
LUW76_16305	COG1217	gtp-binding protein TYPA
LUW76_16310	COG0791	NLP P60 protein
LUW76_16315	COG0494	nUDIX hydrolase
LUW76_16325	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_16375	COG0012	GTP binding
LUW76_16380	COG1322	Protein conserved in bacteria
LUW76_16390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LUW76_16410	COG1722	exodeoxyribonuclease VII activity
LUW76_16435	COG1131	(ABC) transporter
LUW76_16455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW76_16465	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LUW76_16465	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LUW76_16475	COG0114	fumarate hydratase activity
LUW76_16485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LUW76_16490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LUW76_16505	COG1331	Highly conserved protein containing a thioredoxin domain
LUW76_16515	COG1234	tRNA 3'-trailer cleavage
LUW76_16535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW76_16545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LUW76_16555	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LUW76_16570	COG1714	RDD family
LUW76_16575	COG0308	aminopeptidase N
LUW76_16585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LUW76_16600	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LUW76_16615	COG0657	acetylesterase activity
LUW76_16615	COG2755	lipolytic protein G-D-S-L family
LUW76_16625	COG2409	Drug exporters of the RND superfamily
LUW76_16635	COG2755	lipolytic protein G-D-S-L family
LUW76_16640	COG0183	Belongs to the thiolase family
LUW76_16660	COG1252	NADH dehydrogenase
LUW76_16690	COG0148	phosphopyruvate hydratase activity
LUW76_16695	COG2205	protein histidine kinase activity
LUW76_16710	COG0604	alcohol dehydrogenase
LUW76_16710	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_16710	COG3321	synthase
LUW76_16715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW76_16740	COG0529	Catalyzes the synthesis of activated sulfate
LUW76_16740	COG2046	Belongs to the sulfate adenylyltransferase family
LUW76_16745	COG0730	response to heat
LUW76_16825	COG1218	3'(2'),5'-bisphosphate nucleotidase
LUW76_16835	COG0193	aminoacyl-tRNA hydrolase activity
LUW76_16840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LUW76_16845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LUW76_16850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LUW76_16865	COG1309	transcriptional regulator
LUW76_16870	COG4106	trans-aconitate 2-methyltransferase activity
LUW76_16880	COG0154	amidase activity
LUW76_16885	COG0488	(ABC) transporter
LUW76_16900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LUW76_16905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LUW76_16905	COG4124	Belongs to the glycosyl hydrolase 26 family
LUW76_16910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LUW76_16925	COG0084	hydrolase, TatD family'
LUW76_16930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LUW76_16975	COG1609	Transcriptional regulator
LUW76_16980	COG0598	Magnesium transport protein CorA
LUW76_16995	COG0583	DNA-binding transcription factor activity
LUW76_17010	COG0154	amidase activity
LUW76_17045	COG0515	serine threonine protein kinase
LUW76_17045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW76_17055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_17085	COG3655	Transcriptional regulator
LUW76_17095	COG0477	Major facilitator Superfamily
LUW76_17170	COG0457	Tetratricopeptide repeat
LUW76_17185	COG2255	four-way junction helicase activity
LUW76_17210	COG0640	Transcriptional regulator
LUW76_17220	COG1132	(ABC) transporter
LUW76_17270	COG1280	lysine exporter protein (LysE YggA)
LUW76_17275	COG1309	transcriptional regulator
LUW76_17295	COG2197	response regulator
LUW76_17320	COG0438	transferase activity, transferring glycosyl groups
LUW76_17330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LUW76_17355	COG2124	cytochrome p450
LUW76_17360	COG3851	Histidine kinase
LUW76_17365	COG2197	response regulator
LUW76_17375	COG0515	serine threonine protein kinase
LUW76_17380	COG0515	serine threonine protein kinase
LUW76_17380	COG2815	serine threonine protein kinase
LUW76_17385	COG0515	serine threonine protein kinase
LUW76_17390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LUW76_17390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LUW76_17460	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_17495	COG1846	Transcriptional regulator
LUW76_17505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW76_17535	COG2070	2-Nitropropane dioxygenase
LUW76_17555	COG4981	capsule polysaccharide biosynthetic process
LUW76_17565	COG1216	Glycosyl transferase, family 2
LUW76_17580	COG1960	acyl-CoA dehydrogenase activity
LUW76_17595	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_17600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_17600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_17665	COG3903	Transcriptional regulator
LUW76_17665	COG3629	intracellular signal transduction
LUW76_17670	COG0641	radical SAM
LUW76_17675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_17695	COG0583	DNA-binding transcription factor activity
LUW76_17730	COG1492	cobalamin metabolic process
LUW76_17735	COG1473	amidohydrolase
LUW76_17750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LUW76_17755	COG0793	Belongs to the peptidase S41A family
LUW76_17760	COG2177	Part of the ABC transporter FtsEX involved in
LUW76_17765	COG2884	Cell division ATP-binding protein ftsE
LUW76_17780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LUW76_17795	COG2902	Dehydrogenase
LUW76_17810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW76_17820	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_17825	COG1595	DNA-templated transcription, initiation
LUW76_17845	COG1131	(ABC) transporter
LUW76_17855	COG1011	Hydrolase
LUW76_17860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LUW76_17875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW76_17880	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW76_17890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LUW76_17895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LUW76_17905	COG1263	PTS System
LUW76_17905	COG2190	(PTS) system
LUW76_17905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LUW76_17910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LUW76_17915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LUW76_17920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LUW76_17930	COG1263	PTS System
LUW76_17940	COG0653	protein targeting
LUW76_17950	COG3214	Protein conserved in bacteria
LUW76_17960	COG2197	response regulator
LUW76_17965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LUW76_17970	COG1040	competence protein
LUW76_17980	COG5401	PFAM Sporulation and spore germination
LUW76_17990	COG0745	RESPONSE REGULATOR receiver
LUW76_18015	COG0714	Associated with various cellular activities
LUW76_18045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LUW76_18050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LUW76_18065	COG2197	response regulator
LUW76_18070	COG4585	Histidine kinase
LUW76_18085	COG2835	tetraacyldisaccharide 4'-kinase activity
LUW76_18090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LUW76_18145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LUW76_18150	COG0778	Nitroreductase
LUW76_18150	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LUW76_18155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LUW76_18165	COG0583	DNA-binding transcription factor activity
LUW76_18195	COG0438	transferase activity, transferring glycosyl groups
LUW76_18200	COG2226	methyltransferase
LUW76_18200	COG1073	alpha beta
LUW76_18210	COG3118	belongs to the thioredoxin family
LUW76_18215	COG0438	transferase activity, transferring glycosyl groups
LUW76_18235	COG3594	Acyltransferase
LUW76_18240	COG3594	Acyltransferase
LUW76_18245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW76_18250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW76_18260	COG0438	transferase activity, transferring glycosyl groups
LUW76_18300	COG0438	transferase activity, transferring glycosyl groups
LUW76_18320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LUW76_18340	COG3973	AAA domain
LUW76_18370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LUW76_18390	COG1316	TRANSCRIPTIONal
LUW76_18410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LUW76_18415	COG1832	CoA-binding protein
LUW76_18430	COG3850	Histidine kinase
LUW76_18450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LUW76_18465	COG2205	protein histidine kinase activity
LUW76_18470	COG0745	RESPONSE REGULATOR receiver
LUW76_18505	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_18515	COG1024	Enoyl-CoA hydratase
LUW76_18535	COG3795	YCII-related domain
LUW76_18545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LUW76_18550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LUW76_18560	COG1432	Conserved Protein
LUW76_18635	COG1674	ftsk spoiiie
LUW76_18650	COG4770	biotin carboxylase activity
LUW76_18675	COG2197	response regulator
LUW76_18715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LUW76_18755	COG0640	Transcriptional regulator
LUW76_18760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LUW76_18780	COG2315	Protein conserved in bacteria
LUW76_18815	COG0583	DNA-binding transcription factor activity
LUW76_18845	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_18855	COG2936	dipeptidyl-peptidase activity
LUW76_18870	COG1079	Belongs to the binding-protein-dependent transport system permease family
LUW76_18880	COG3845	ABC transporter
LUW76_18885	COG1744	ABC transporter substrate-binding protein PnrA-like
LUW76_18890	COG1473	amidohydrolase
LUW76_18890	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW76_18895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW76_18900	COG1686	Belongs to the peptidase S11 family
LUW76_18910	COG1295	ribonuclease BN
LUW76_18925	COG1253	flavin adenine dinucleotide binding
LUW76_18935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LUW76_18950	COG0326	Molecular chaperone. Has ATPase activity
LUW76_18960	COG1672	PFAM Archaeal ATPase
LUW76_18960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_18965	COG2197	response regulator
LUW76_18985	COG1404	Belongs to the peptidase S8 family
LUW76_18985	COG4412	M6 family metalloprotease domain protein
LUW76_18990	COG0039	L-malate dehydrogenase activity
LUW76_19010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LUW76_19025	COG0138	bifunctional purine biosynthesis protein purh
LUW76_19060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_19080	COG2223	nitrite transmembrane transporter activity
LUW76_19085	COG2207	Transcriptional regulator
LUW76_19105	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LUW76_19125	COG1490	D-aminoacyl-tRNA deacylase activity
LUW76_19130	COG3246	L-lysine catabolic process to acetate
LUW76_19145	COG2807	transmembrane transport
LUW76_19150	COG2186	Transcriptional regulator
LUW76_19185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LUW76_19190	COG1309	transcriptional regulator
LUW76_19195	COG2409	Drug exporters of the RND superfamily
LUW76_19250	COG1595	DNA-templated transcription, initiation
LUW76_19270	COG2084	Dehydrogenase
LUW76_19300	COG3442	glutamine amidotransferase
LUW76_19305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LUW76_19330	COG0640	Transcriptional regulator
LUW76_19380	COG1216	Glycosyl transferase, family 2
LUW76_19415	COG3119	arylsulfatase activity
LUW76_19435	COG1316	TRANSCRIPTIONal
LUW76_19545	COG1404	Belongs to the peptidase S8 family
LUW76_19565	COG4842	Belongs to the WXG100 family
LUW76_19580	COG1674	ftsk spoiiie
LUW76_19655	COG0745	RESPONSE REGULATOR receiver
LUW76_19680	COG0456	acetyltransferase
LUW76_19685	COG0737	Belongs to the 5'-nucleotidase family
LUW76_19685	COG1525	nuclease
LUW76_19685	COG4085	toxin activity
LUW76_19695	COG1392	Phosphate transport regulator
LUW76_19705	COG0464	growth
LUW76_19720	COG0242	peptide deformylase activity
LUW76_19725	COG0745	RESPONSE REGULATOR receiver
LUW76_19730	COG2205	protein histidine kinase activity
LUW76_19735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW76_19745	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LUW76_19785	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_19820	COG1902	pentaerythritol trinitrate reductase activity
LUW76_19830	COG4566	intracellular signal transduction
LUW76_19870	COG3118	belongs to the thioredoxin family
LUW76_19875	COG0071	Belongs to the small heat shock protein (HSP20) family
LUW76_19885	COG2197	response regulator
LUW76_19895	COG2814	Major facilitator Superfamily
LUW76_19905	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_19905	COG1672	PFAM Archaeal ATPase
LUW76_19915	COG0443	Heat shock 70 kDa protein
LUW76_19920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LUW76_19935	COG0542	response to heat
LUW76_19940	COG3285	dna ligase
LUW76_19940	COG1793	dna ligase
LUW76_19955	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LUW76_19980	COG3842	ATPase activity
LUW76_19990	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW76_20035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LUW76_20040	COG1473	amidohydrolase
LUW76_20050	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_20060	COG1473	amidohydrolase
LUW76_20065	COG4608	Belongs to the ABC transporter superfamily
LUW76_20070	COG0444	Belongs to the ABC transporter superfamily
LUW76_20075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW76_20080	COG0601	transmembrane transport
LUW76_20085	COG0747	negative chemotaxis
LUW76_20090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_20115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LUW76_20125	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_20130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LUW76_20185	COG0667	Aldo Keto reductase
LUW76_20190	COG0129	dihydroxy-acid dehydratase activity
LUW76_20195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW76_20200	COG3387	PFAM Glycoside hydrolase 15-related
LUW76_20205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LUW76_20220	COG0431	NADPH-dependent FMN reductase
LUW76_20230	COG0028	Belongs to the TPP enzyme family
LUW76_20245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LUW76_20270	COG1191	sigma factor activity
LUW76_20300	COG1234	tRNA 3'-trailer cleavage
LUW76_20305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_20310	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_20335	COG0596	Alpha beta hydrolase
LUW76_20345	COG2409	Drug exporters of the RND superfamily
LUW76_20355	COG0745	RESPONSE REGULATOR receiver
LUW76_20400	COG1132	(ABC) transporter
LUW76_20405	COG1132	(ABC) transporter
LUW76_20410	COG0515	serine threonine protein kinase
LUW76_20415	COG0515	serine threonine protein kinase
LUW76_20445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LUW76_20455	COG2130	NADP-dependent
LUW76_20460	COG1309	transcriptional regulator
LUW76_20470	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_20475	COG1024	Enoyl-CoA hydratase
LUW76_20490	COG0183	Belongs to the thiolase family
LUW76_20515	COG1129	ABC transporter
LUW76_20530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LUW76_20540	COG1960	acyl-CoA dehydrogenase activity
LUW76_20545	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_20565	COG2837	iron assimilation
LUW76_20615	COG3903	Transcriptional regulator
LUW76_20615	COG3629	intracellular signal transduction
LUW76_20620	COG1024	Enoyl-CoA hydratase
LUW76_20640	COG4221	oxidoreductase activity
LUW76_20660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_20665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_20665	COG1116	anion transmembrane transporter activity
LUW76_20675	COG0431	NADPH-dependent FMN reductase
LUW76_20715	COG3387	PFAM Glycoside hydrolase 15-related
LUW76_20730	COG0477	Major facilitator Superfamily
LUW76_20765	COG2226	methyltransferase
LUW76_20840	COG2018	Roadblock/LC7 domain
LUW76_20885	COG1129	ABC transporter
LUW76_20890	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_20910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LUW76_20930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW76_20935	COG3386	PFAM SMP-30 Gluconolaconase
LUW76_20945	COG1609	Transcriptional regulator
LUW76_20950	COG0596	Alpha beta hydrolase
LUW76_21040	COG1959	2 iron, 2 sulfur cluster binding
LUW76_21055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LUW76_21060	COG1115	amino acid carrier protein
LUW76_21065	COG1793	dna ligase
LUW76_21100	COG2353	YceI-like domain
LUW76_21135	COG1228	amidohydrolase
LUW76_21145	COG3629	intracellular signal transduction
LUW76_21160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LUW76_21245	COG1021	2,3-dihydroxybenzoate-AMP ligase
LUW76_21260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW76_21330	COG1309	transcriptional regulator
LUW76_21335	COG0604	alcohol dehydrogenase
LUW76_21345	COG5398	heme oxygenase
LUW76_21375	COG4558	Periplasmic binding protein
LUW76_21380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW76_21385	COG1120	ATPase activity
LUW76_21400	COG2186	Transcriptional regulator
LUW76_21405	COG2807	transmembrane transport
LUW76_21415	COG2814	Major facilitator Superfamily
LUW76_21420	COG0439	Biotin carboxylase
LUW76_21450	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_21480	COG0596	Alpha beta hydrolase
LUW76_21485	COG0066	3-isopropylmalate dehydratase activity
LUW76_21490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LUW76_21495	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LUW76_21510	COG1414	Transcriptional regulator
LUW76_21535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_21540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_21545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_21545	COG1116	anion transmembrane transporter activity
LUW76_21570	COG1454	alcohol dehydrogenase
LUW76_21580	COG0583	DNA-binding transcription factor activity
LUW76_21595	COG1309	transcriptional regulator
LUW76_21605	COG1414	Transcriptional regulator
LUW76_21615	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_21620	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_21625	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_21640	COG3594	Acyltransferase
LUW76_21690	COG0438	transferase activity, transferring glycosyl groups
LUW76_21700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LUW76_21720	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_21730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LUW76_21740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LUW76_21750	COG3279	Response regulator of the LytR AlgR family
LUW76_21755	COG3275	phosphorelay sensor kinase activity
LUW76_21770	COG1279	arginine transmembrane transporter activity
LUW76_21775	COG1917	Cupin 2, conserved barrel domain protein
LUW76_21775	COG4977	sequence-specific DNA binding
LUW76_21815	COG0596	Alpha beta hydrolase
LUW76_21835	COG1960	acyl-CoA dehydrogenase activity
LUW76_21845	COG1024	Enoyl-CoA hydratase
LUW76_21850	COG1960	acyl-CoA dehydrogenase activity
LUW76_21870	COG0737	Belongs to the 5'-nucleotidase family
LUW76_21905	COG4977	sequence-specific DNA binding
LUW76_21915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LUW76_21940	COG4935	Belongs to the peptidase S8 family
LUW76_21940	COG2234	aminopeptidase activity
LUW76_21955	COG1960	acyl-CoA dehydrogenase activity
LUW76_21965	COG0477	Major facilitator Superfamily
LUW76_22035	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_22105	COG2274	protein secretion by the type I secretion system
LUW76_22110	COG3629	intracellular signal transduction
LUW76_22110	COG3903	Transcriptional regulator
LUW76_22120	COG3903	Transcriptional regulator
LUW76_22120	COG3629	intracellular signal transduction
LUW76_22125	COG0477	Major facilitator Superfamily
LUW76_22165	COG1309	transcriptional regulator
LUW76_22175	COG0583	DNA-binding transcription factor activity
LUW76_22200	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_22240	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_22275	COG2423	ornithine cyclodeaminase activity
LUW76_22285	COG0583	DNA-binding transcription factor activity
LUW76_22300	COG2151	metal-sulfur cluster biosynthetic enzyme
LUW76_22300	COG0489	protein tyrosine kinase activity
LUW76_22310	COG0243	molybdopterin cofactor binding
LUW76_22330	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LUW76_22340	COG2186	Transcriptional regulator
LUW76_22350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_22355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_22355	COG1116	anion transmembrane transporter activity
LUW76_22365	COG2009	succinate dehydrogenase
LUW76_22370	COG1053	succinate dehydrogenase
LUW76_22375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LUW76_22380	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LUW76_22385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW76_22390	COG2721	sulfolactate sulfo-lyase activity
LUW76_22395	COG2721	sulfolactate sulfo-lyase activity
LUW76_22425	COG1802	Transcriptional regulator
LUW76_22435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW76_22445	COG5522	Integral membrane protein (intg_mem_TP0381)
LUW76_22470	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_22510	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_22515	COG1309	transcriptional regulator
LUW76_22520	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_22530	COG1129	ABC transporter
LUW76_22555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_22580	COG0464	growth
LUW76_22585	COG0583	DNA-binding transcription factor activity
LUW76_22590	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_22645	COG0584	glycerophosphoryl diester phosphodiesterase
LUW76_22655	COG1113	amino acid transport
LUW76_22660	COG1113	amino acid transport
LUW76_22700	COG1846	Transcriptional regulator
LUW76_22720	COG1942	4-Oxalocrotonate Tautomerase
LUW76_22750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_22760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_22765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_22765	COG1116	anion transmembrane transporter activity
LUW76_22770	COG2186	Transcriptional regulator
LUW76_22815	COG0604	alcohol dehydrogenase
LUW76_22860	COG0583	DNA-binding transcription factor activity
LUW76_22865	COG1760	l-serine dehydratase
LUW76_22870	COG3620	sequence-specific DNA binding
LUW76_22885	COG0765	amino acid transport
LUW76_22890	COG1126	abc transporter atp-binding protein
LUW76_22895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_22940	COG1132	(ABC) transporter
LUW76_22945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_22970	COG2226	methyltransferase
LUW76_22985	COG1082	Xylose isomerase domain protein TIM barrel
LUW76_22990	COG2814	Major facilitator Superfamily
LUW76_23015	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW76_23055	COG0492	ferredoxin-NADP+ reductase activity
LUW76_23070	COG0438	transferase activity, transferring glycosyl groups
LUW76_23080	COG0438	transferase activity, transferring glycosyl groups
LUW76_23095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LUW76_23130	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LUW76_23155	COG0464	growth
LUW76_23200	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_23240	COG2267	carboxylic ester hydrolase activity
LUW76_23255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LUW76_23260	COG1959	2 iron, 2 sulfur cluster binding
LUW76_23285	COG2226	methyltransferase
LUW76_23335	COG0167	dihydroorotate dehydrogenase activity
LUW76_23340	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW76_23355	COG1609	Transcriptional regulator
LUW76_23360	COG1309	transcriptional regulator
LUW76_23385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LUW76_23430	COG4974	Belongs to the 'phage' integrase family
LUW76_23445	COG1674	ftsk spoiiie
LUW76_23460	COG2188	Transcriptional regulator
LUW76_23510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LUW76_23515	COG0047	phosphoribosylformylglycinamidine synthase activity
LUW76_23530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LUW76_23545	COG0022	dehydrogenase e1 component
LUW76_23550	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW76_23565	COG0697	spore germination
LUW76_23575	COG1960	acyl-CoA dehydrogenase activity
LUW76_23580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LUW76_23585	COG2076	Multidrug Resistance protein
LUW76_23660	COG0406	alpha-ribazole phosphatase activity
LUW76_23660	COG0494	nUDIX hydrolase
LUW76_23665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LUW76_23685	COG1595	DNA-templated transcription, initiation
LUW76_23690	COG2204	response regulator
LUW76_23695	COG4251	negative regulation of phosphorylation
LUW76_23700	COG0784	Response regulator, receiver
LUW76_23730	COG1799	cell septum assembly
LUW76_23745	COG0745	RESPONSE REGULATOR receiver
LUW76_23765	COG2205	protein histidine kinase activity
LUW76_23770	COG2205	protein histidine kinase activity
LUW76_23780	COG1960	acyl-CoA dehydrogenase activity
LUW76_23880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LUW76_23910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LUW76_23955	COG0416	fatty acid biosynthetic process
LUW76_23965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LUW76_23975	COG1233	COG1233 Phytoene dehydrogenase and related
LUW76_23985	COG2770	Histidine kinase
LUW76_23985	COG2208	phosphoserine phosphatase activity
LUW76_23990	COG0596	Alpha beta hydrolase
LUW76_24015	COG2197	response regulator
LUW76_24030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LUW76_24035	COG0633	Ferredoxin
LUW76_24035	COG0543	2 iron, 2 sulfur cluster binding
LUW76_24045	COG1064	alcohol dehydrogenase
LUW76_24065	COG2706	6-phosphogluconolactonase activity
LUW76_24070	COG1733	regulation of RNA biosynthetic process
LUW76_24150	COG0577	efflux transmembrane transporter activity
LUW76_24150	COG1136	(ABC) transporter
LUW76_24170	COG0515	serine threonine protein kinase
LUW76_24170	COG2815	serine threonine protein kinase
LUW76_24190	COG1247	-acetyltransferase
LUW76_24270	COG0714	Associated with various cellular activities
LUW76_24320	COG0745	RESPONSE REGULATOR receiver
LUW76_24360	COG1733	regulation of RNA biosynthetic process
LUW76_24375	COG0028	Belongs to the TPP enzyme family
LUW76_24390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LUW76_24440	COG1309	transcriptional regulator
LUW76_24490	COG0247	lactate metabolic process
LUW76_24490	COG2181	nitrate reductase activity
LUW76_24510	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_24515	COG0477	Major facilitator Superfamily
LUW76_24540	COG1595	DNA-templated transcription, initiation
LUW76_24545	COG1404	Belongs to the peptidase S8 family
LUW76_24600	COG0443	Heat shock 70 kDa protein
LUW76_24605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LUW76_24610	COG0484	heat shock protein binding
LUW76_24615	COG0789	Transcriptional regulator
LUW76_24620	COG0542	response to heat
LUW76_24645	COG4941	Belongs to the sigma-70 factor family
LUW76_24650	COG3795	YCII-related domain
LUW76_24660	COG0596	Alpha beta hydrolase
LUW76_24705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LUW76_24715	COG0586	Pfam SNARE associated Golgi protein
LUW76_24750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LUW76_24760	COG0598	Magnesium transport protein CorA
LUW76_24765	COG0151	Belongs to the GarS family
LUW76_24770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LUW76_24775	COG0633	Ferredoxin
LUW76_24775	COG3217	Mosc domain protein beta barrel domain protein
LUW76_24785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LUW76_24810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW76_24825	COG2268	Band 7 protein
LUW76_24850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_24875	COG0515	serine threonine protein kinase
LUW76_24885	COG1253	flavin adenine dinucleotide binding
LUW76_24905	COG1950	PFAM Membrane protein of
LUW76_24915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LUW76_24920	COG0514	ATP-dependent DNA helicase (RecQ)
LUW76_24940	COG0745	RESPONSE REGULATOR receiver
LUW76_24950	COG2205	protein histidine kinase activity
LUW76_24955	COG2267	carboxylic ester hydrolase activity
LUW76_24960	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_25020	COG3883	PFAM NLP P60 protein
LUW76_25020	COG0791	NLP P60 protein
LUW76_25160	COG1960	acyl-CoA dehydrogenase activity
LUW76_25175	COG2207	Transcriptional regulator
LUW76_25185	COG1793	dna ligase
LUW76_25200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LUW76_25260	COG1518	maintenance of DNA repeat elements
LUW76_25265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LUW76_25300	COG0358	DNA primase activity
LUW76_25410	COG0300	oxidoreductase activity
LUW76_25435	COG0022	dehydrogenase e1 component
LUW76_25440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LUW76_25445	COG0022	dehydrogenase e1 component
LUW76_25450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LUW76_25455	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW76_25465	COG4948	Mandelate Racemase Muconate Lactonizing
LUW76_25480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_25500	COG0431	NADPH-dependent FMN reductase
LUW76_25510	COG2271	Major facilitator Superfamily
LUW76_25530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_25535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_25540	COG3485	protocatechuate 3,4-dioxygenase
LUW76_25575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LUW76_25580	COG0477	Major facilitator Superfamily
LUW76_25590	COG0583	DNA-binding transcription factor activity
LUW76_25610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_25620	COG0559	Belongs to the binding-protein-dependent transport system permease family
LUW76_25655	COG1960	acyl-CoA dehydrogenase activity
LUW76_25660	COG1960	acyl-CoA dehydrogenase activity
LUW76_25665	COG0183	Belongs to the thiolase family
LUW76_25675	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_25700	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_25705	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_25715	COG2130	NADP-dependent
LUW76_25740	COG1233	COG1233 Phytoene dehydrogenase and related
LUW76_25755	COG0789	Transcriptional regulator
LUW76_25765	COG0583	DNA-binding transcription factor activity
LUW76_25770	COG1024	Enoyl-CoA hydratase
LUW76_25775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW76_25840	COG1309	transcriptional regulator
LUW76_25860	COG0477	Major facilitator Superfamily
LUW76_25865	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW76_25865	COG2319	Wd-40 repeat
LUW76_25870	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LUW76_25890	COG3850	Histidine kinase
LUW76_25895	COG2197	response regulator
LUW76_25905	COG3903	Transcriptional regulator
LUW76_25905	COG3629	intracellular signal transduction
LUW76_25985	COG0477	Major facilitator Superfamily
LUW76_25995	COG1476	TRANSCRIPTIONal
LUW76_26005	COG1846	Transcriptional regulator
LUW76_26015	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LUW76_26020	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_26035	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_26040	COG1595	DNA-templated transcription, initiation
LUW76_26070	COG1846	Transcriptional regulator
LUW76_26145	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LUW76_26165	COG0604	alcohol dehydrogenase
LUW76_26175	COG0561	phosphatase activity
LUW76_26180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LUW76_26185	COG2226	methyltransferase
LUW76_26190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LUW76_26205	COG5650	phosphatidylinositol metabolic process
LUW76_26235	COG5002	protein histidine kinase activity
LUW76_26240	COG0745	RESPONSE REGULATOR receiver
LUW76_26270	COG2235	arginine
LUW76_26280	COG5002	protein histidine kinase activity
LUW76_26290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW76_26305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LUW76_26330	COG1902	pentaerythritol trinitrate reductase activity
LUW76_26350	COG1595	DNA-templated transcription, initiation
LUW76_26385	COG0140	phosphoribosyl-ATP diphosphatase activity
LUW76_26385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LUW76_26435	COG0789	Transcriptional regulator
LUW76_26470	COG0789	Transcriptional regulator
LUW76_26550	COG0477	Major facilitator Superfamily
LUW76_26555	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_26585	COG2018	Roadblock/LC7 domain
LUW76_26610	COG0577	efflux transmembrane transporter activity
LUW76_26610	COG1136	(ABC) transporter
LUW76_26615	COG1136	(ABC) transporter
LUW76_26630	COG0745	RESPONSE REGULATOR receiver
LUW76_26640	COG2205	protein histidine kinase activity
LUW76_26650	COG4585	Histidine kinase
LUW76_26655	COG2197	response regulator
LUW76_26670	COG1716	ATPase activity
LUW76_26685	COG0768	penicillin binding
LUW76_26690	COG0515	serine threonine protein kinase
LUW76_26695	COG0515	serine threonine protein kinase
LUW76_26710	COG3764	Sortase (surface protein transpeptidase)
LUW76_26725	COG0705	Rhomboid family
LUW76_26745	COG0596	Alpha beta hydrolase
LUW76_26755	COG0513	Belongs to the DEAD box helicase family
LUW76_26760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW76_26775	COG1271	oxidase subunit
LUW76_26780	COG1294	oxidase, subunit
LUW76_26785	COG4988	ABC transporter
LUW76_26815	COG0154	amidase activity
LUW76_26820	COG1609	Transcriptional regulator
LUW76_26845	COG0667	Aldo Keto reductase
LUW76_26855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW76_26865	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_26875	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_26885	COG1247	-acetyltransferase
LUW76_26890	COG2226	methyltransferase
LUW76_26895	COG0640	Transcriptional regulator
LUW76_26905	COG0640	Transcriptional regulator
LUW76_26970	COG0346	lactoylglutathione lyase activity
LUW76_26980	COG3266	domain, Protein
LUW76_26985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LUW76_26995	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LUW76_27000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LUW76_27010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LUW76_27015	COG0592	DNA-directed DNA polymerase activity
LUW76_27020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LUW76_27025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LUW76_27030	COG0594	ribonuclease P activity
LUW76_27035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LUW76_27040	COG0706	membrane insertase activity
LUW76_27055	COG0357	Ribosomal RNA small subunit methyltransferase G
LUW76_27060	COG1192	Involved in chromosome partitioning
LUW76_27095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW76_27105	COG3118	belongs to the thioredoxin family
LUW76_27110	COG0492	ferredoxin-NADP+ reductase activity
LUW76_27125	COG1595	DNA-templated transcription, initiation
LUW76_27130	COG0515	serine threonine protein kinase
LUW76_27130	COG2815	serine threonine protein kinase
LUW76_27155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LUW76_27165	COG4166	transmembrane transport
LUW76_27185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW76_27200	COG0789	Transcriptional regulator
LUW76_27220	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LUW76_27235	COG0360	Binds together with S18 to 16S ribosomal RNA
LUW76_27240	COG0629	single-stranded DNA binding
LUW76_27245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LUW76_27250	COG0359	binds to the 23S rRNA
LUW76_27265	COG0534	Mate efflux family protein
LUW76_27270	COG0305	Participates in initiation and elongation during chromosome replication
LUW76_27295	COG2318	DinB family
LUW76_27305	COG1595	DNA-templated transcription, initiation
LUW76_27320	COG1846	Transcriptional regulator
LUW76_27340	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW76_27375	COG0592	DNA-directed DNA polymerase activity
LUW76_27395	COG0537	adenosine 5'-monophosphoramidase activity
LUW76_27460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LUW76_27490	COG2186	Transcriptional regulator
LUW76_27495	COG2807	transmembrane transport
LUW76_27545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LUW76_27565	COG0189	ligase activity
LUW76_27570	COG0246	Mannitol dehydrogenase
LUW76_27580	COG0745	RESPONSE REGULATOR receiver
LUW76_27600	COG1309	transcriptional regulator
LUW76_27615	COG1846	Transcriptional regulator
LUW76_27650	COG3629	intracellular signal transduction
LUW76_27650	COG3903	Transcriptional regulator
LUW76_27665	COG0860	N-Acetylmuramoyl-L-alanine amidase
LUW76_27705	COG0515	serine threonine protein kinase
LUW76_27775	COG1408	metallophosphoesterase
LUW76_27785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LUW76_27800	COG0667	Aldo Keto reductase
LUW76_27805	COG0003	Pfam Anion-transporting ATPase
LUW76_27865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_27870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_27885	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_27900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW76_27910	COG0596	Alpha beta hydrolase
LUW76_27920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LUW76_28000	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_28000	COG1672	PFAM Archaeal ATPase
LUW76_28050	COG0560	Phosphoserine phosphatase
LUW76_28050	COG3830	Belongs to the UPF0237 family
LUW76_28055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LUW76_28065	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_28075	COG2197	response regulator
LUW76_28100	COG1119	ATPase activity
LUW76_28145	COG2843	Capsule synthesis protein
LUW76_28190	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_28200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_28205	COG2188	Transcriptional regulator
LUW76_28210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LUW76_28255	COG1280	lysine exporter protein (LysE YggA)
LUW76_28260	COG1522	sequence-specific DNA binding
LUW76_28270	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LUW76_28270	COG3321	synthase
LUW76_28270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW76_28270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW76_28290	COG1819	glycosyl
LUW76_28300	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_28310	COG1414	Transcriptional regulator
LUW76_28315	COG3339	Conserved Protein
LUW76_28325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LUW76_28345	COG1309	transcriptional regulator
LUW76_28400	COG1595	DNA-templated transcription, initiation
LUW76_28420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW76_28450	COG2205	protein histidine kinase activity
LUW76_28455	COG0745	RESPONSE REGULATOR receiver
LUW76_28500	COG1595	DNA-templated transcription, initiation
LUW76_28530	COG2197	response regulator
LUW76_28540	COG2409	Drug exporters of the RND superfamily
LUW76_28545	COG0726	polysaccharide deacetylase
LUW76_28560	COG0477	Major facilitator Superfamily
LUW76_28570	COG2197	response regulator
LUW76_28580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW76_28600	COG0300	oxidoreductase activity
LUW76_28615	COG1309	transcriptional regulator
LUW76_28620	COG2409	Drug exporters of the RND superfamily
LUW76_28625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_28650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LUW76_28665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LUW76_28695	COG1960	acyl-CoA dehydrogenase activity
LUW76_28715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LUW76_28740	COG3795	YCII-related domain
LUW76_28745	COG4941	Belongs to the sigma-70 factor family
LUW76_28765	COG3118	belongs to the thioredoxin family
LUW76_28770	COG3304	Inner membrane component domain
LUW76_28775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LUW76_28810	COG2197	response regulator
LUW76_28815	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LUW76_28840	COG4977	sequence-specific DNA binding
LUW76_28905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LUW76_28925	COG0542	response to heat
LUW76_28940	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LUW76_28955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LUW76_28960	COG2151	metal-sulfur cluster biosynthetic enzyme
LUW76_28965	COG3396	Phenylacetate-CoA oxygenase
LUW76_28970	COG3460	Phenylacetate-CoA oxygenase
LUW76_28975	COG3396	Phenylacetate-CoA oxygenase
LUW76_28985	COG1309	transcriptional regulator
LUW76_29015	COG3401	FG-GAP repeat protein
LUW76_29020	COG3866	Pectate lyase
LUW76_29030	COG0701	Predicted permease
LUW76_29060	COG2885	chlorophyll binding
LUW76_29070	COG1309	transcriptional regulator
LUW76_29095	COG4585	Histidine kinase
LUW76_29100	COG2197	response regulator
LUW76_29115	COG2079	MmgE PrpD family protein
LUW76_29130	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_29140	COG3842	ATPase activity
LUW76_29150	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW76_29155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LUW76_29160	COG1063	alcohol dehydrogenase
LUW76_29165	COG0667	Aldo Keto reductase
LUW76_29170	COG1309	transcriptional regulator
LUW76_29175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LUW76_29180	COG0583	DNA-binding transcription factor activity
LUW76_29200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LUW76_29230	COG0583	DNA-binding transcription factor activity
LUW76_29240	COG1304	FMN binding
LUW76_29250	COG0583	DNA-binding transcription factor activity
LUW76_29255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_29260	COG1024	Enoyl-CoA hydratase
LUW76_29315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LUW76_29325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LUW76_29355	COG3960	tartronate-semialdehyde synthase activity
LUW76_29360	COG2072	flavoprotein involved in K transport
LUW76_29385	COG1177	transmembrane transport
LUW76_29390	COG3842	ATPase activity
LUW76_29410	COG2084	Dehydrogenase
LUW76_29420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LUW76_29460	COG0477	Major facilitator Superfamily
LUW76_29470	COG3629	intracellular signal transduction
LUW76_29470	COG3903	Transcriptional regulator
LUW76_29475	COG2319	Wd-40 repeat
LUW76_29475	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW76_29495	COG0702	epimerase
LUW76_29535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_29550	COG0129	dihydroxy-acid dehydratase activity
LUW76_29585	COG0129	dihydroxy-acid dehydratase activity
LUW76_29590	COG1233	COG1233 Phytoene dehydrogenase and related
LUW76_29600	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_29605	COG2197	response regulator
LUW76_29615	COG0477	Major facilitator Superfamily
LUW76_29630	COG2080	2 iron, 2 sulfur cluster binding
LUW76_29645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW76_29650	COG0640	Transcriptional regulator
LUW76_29655	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_29670	COG3639	organic phosphonate transmembrane transporter activity
LUW76_29675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LUW76_29675	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LUW76_29680	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LUW76_29695	COG2814	Major facilitator Superfamily
LUW76_29700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_29705	COG0640	Transcriptional regulator
LUW76_29710	COG1846	Transcriptional regulator
LUW76_29715	COG2226	methyltransferase
LUW76_29745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LUW76_29750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LUW76_29795	COG1754	DNA topoisomerase type I activity
LUW76_29795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LUW76_29800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LUW76_29805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LUW76_29810	COG1404	Belongs to the peptidase S8 family
LUW76_29820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LUW76_29835	COG1774	PSP1 C-terminal conserved region
LUW76_29840	COG0656	L-ascorbic acid biosynthetic process
LUW76_29845	COG0477	Major facilitator Superfamily
LUW76_29850	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_29850	COG0604	alcohol dehydrogenase
LUW76_29850	COG3321	synthase
LUW76_29855	COG0789	Transcriptional regulator
LUW76_29950	COG0791	NLP P60 protein
LUW76_29950	COG3883	PFAM NLP P60 protein
LUW76_29955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LUW76_29960	COG2027	D-alanyl-D-alanine carboxypeptidase
LUW76_29970	COG0037	tRNA processing
LUW76_29975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LUW76_29985	COG0302	gtp cyclohydrolase
LUW76_30000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LUW76_30025	COG0649	NAD binding
LUW76_30055	COG2124	cytochrome p450
LUW76_30065	COG4585	Histidine kinase
LUW76_30080	COG1136	(ABC) transporter
LUW76_30085	COG0577	efflux transmembrane transporter activity
LUW76_30095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LUW76_30100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LUW76_30110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LUW76_30120	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LUW76_30125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LUW76_30135	COG1609	Transcriptional regulator
LUW76_30150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LUW76_30180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LUW76_30185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW76_30185	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
LUW76_30195	COG5434	Belongs to the glycosyl hydrolase 28 family
LUW76_30200	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LUW76_30205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LUW76_30215	COG0500	methyltransferase
LUW76_30220	COG1082	Xylose isomerase domain protein TIM barrel
LUW76_30240	COG1316	TRANSCRIPTIONal
LUW76_30245	COG0506	proline dehydrogenase activity
LUW76_30260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LUW76_30265	COG1136	(ABC) transporter
LUW76_30270	COG0577	efflux transmembrane transporter activity
LUW76_30270	COG1136	(ABC) transporter
LUW76_30285	COG0123	including yeast histone deacetylase and acetoin utilization protein
LUW76_30335	COG2814	Major facilitator Superfamily
LUW76_30345	COG2124	cytochrome p450
LUW76_30350	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_30355	COG0789	Transcriptional regulator
LUW76_30425	COG0560	Phosphoserine phosphatase
LUW76_30460	COG0181	hydroxymethylbilane synthase activity
LUW76_30470	COG0113	porphobilinogen synthase activity
LUW76_30480	COG2815	serine threonine protein kinase
LUW76_30480	COG0515	serine threonine protein kinase
LUW76_30490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LUW76_30510	COG0406	alpha-ribazole phosphatase activity
LUW76_30515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LUW76_30520	COG0785	Cytochrome C biogenesis protein
LUW76_30525	COG1333	cytochrome c biogenesis protein
LUW76_30530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LUW76_30560	COG2226	methyltransferase
LUW76_30575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW76_30585	COG0649	NAD binding
LUW76_30600	COG1034	ATP synthesis coupled electron transport
LUW76_30605	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LUW76_30610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW76_30625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW76_30640	COG0142	geranyltranstransferase activity
LUW76_30660	COG5002	protein histidine kinase activity
LUW76_30700	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_30765	COG1013	pyruvate-flavodoxin oxidoreductase activity
LUW76_30770	COG0674	pyruvate-flavodoxin oxidoreductase activity
LUW76_30770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LUW76_30785	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW76_30795	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW76_30800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LUW76_30810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW76_30820	COG0713	ATP synthesis coupled electron transport
LUW76_30835	COG1007	ATP synthesis coupled electron transport
LUW76_30840	COG0501	Belongs to the peptidase M48B family
LUW76_30845	COG1666	GTP binding
LUW76_30900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW76_30990	COG1132	(ABC) transporter
LUW76_31010	COG0681	Belongs to the peptidase S26 family
LUW76_31030	COG1595	DNA-templated transcription, initiation
LUW76_31080	COG1960	acyl-CoA dehydrogenase activity
LUW76_31095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LUW76_31100	COG2030	dehydratase
LUW76_31110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LUW76_31115	COG2119	membrane
LUW76_31120	COG1802	Transcriptional regulator
LUW76_31130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LUW76_31140	COG1595	DNA-templated transcription, initiation
LUW76_31150	COG0436	Aminotransferase
LUW76_31160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LUW76_31170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LUW76_31175	COG0081	regulation of translation
LUW76_31195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LUW76_31200	COG0222	ribosome binding
LUW76_31210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW76_31215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW76_31260	COG0085	RNA polymerase activity
LUW76_31265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LUW76_31300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LUW76_31320	COG1522	sequence-specific DNA binding
LUW76_31325	COG0667	Aldo Keto reductase
LUW76_31340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LUW76_31345	COG0049	tRNA binding
LUW76_31350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LUW76_31355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LUW76_31360	COG0051	transcription antitermination factor activity, RNA binding
LUW76_31365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LUW76_31370	COG0088	Forms part of the polypeptide exit tunnel
LUW76_31375	COG0089	rRNA binding
LUW76_31380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LUW76_31385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LUW76_31390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LUW76_31395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LUW76_31400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LUW76_31405	COG0255	Belongs to the universal ribosomal protein uL29 family
LUW76_31410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LUW76_31415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LUW76_31420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LUW76_31425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LUW76_31430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LUW76_31435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LUW76_31440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LUW76_31445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LUW76_31450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LUW76_31460	COG0200	Binds to the 23S rRNA
LUW76_31465	COG0201	protein transport
LUW76_31470	COG0563	adenylate kinase activity
LUW76_31485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LUW76_31495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LUW76_31500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LUW76_31505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LUW76_31510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LUW76_31515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LUW76_31520	COG0202	RNA polymerase activity
LUW76_31525	COG0203	ribosomal protein L17
LUW76_31530	COG0101	tRNA pseudouridine synthase activity
LUW76_31545	COG2340	Cysteine-rich secretory protein family
LUW76_31550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LUW76_31555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LUW76_31560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LUW76_31580	COG1131	(ABC) transporter
LUW76_31600	COG2197	response regulator
LUW76_31605	COG4585	Histidine kinase
LUW76_31610	COG2409	Drug exporters of the RND superfamily
LUW76_31615	COG3831	ATPase activity
LUW76_31625	COG1072	(Pantothenic acid kinase))
LUW76_31630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LUW76_31670	COG1063	alcohol dehydrogenase
LUW76_31675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LUW76_31685	COG0802	atpase or kinase
LUW76_31695	COG1214	PFAM Peptidase M22, glycoprotease
LUW76_31695	COG0456	acetyltransferase
LUW76_31705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LUW76_31725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LUW76_31730	COG0459	protein refolding
LUW76_31735	COG1595	DNA-templated transcription, initiation
LUW76_31755	COG0516	GMP reductase activity
LUW76_31760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LUW76_31785	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_31830	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LUW76_31835	COG1216	Glycosyl transferase, family 2
LUW76_31840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW76_31845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW76_31850	COG0500	methyltransferase
LUW76_31930	COG2197	response regulator
LUW76_31960	COG2376	Dihydroxyacetone kinase
LUW76_31965	COG1461	Dihydroxyacetone kinase
LUW76_31990	COG0596	Alpha beta hydrolase
LUW76_32030	COG1764	response to oxidative stress
LUW76_32035	COG0641	radical SAM
LUW76_32090	COG2318	DinB family
LUW76_32115	COG0778	Nitroreductase
LUW76_32120	COG5650	phosphatidylinositol metabolic process
LUW76_32130	COG2197	response regulator
LUW76_32160	COG0180	Tryptophanyl-tRNA synthetase
LUW76_32185	COG0504	CTP synthase activity
LUW76_32205	COG3384	dioxygenase
LUW76_32215	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LUW76_32250	COG0588	phosphoglycerate mutase activity
LUW76_32260	COG2814	Major facilitator Superfamily
LUW76_32285	COG0745	RESPONSE REGULATOR receiver
LUW76_32305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LUW76_32335	COG4941	Belongs to the sigma-70 factor family
LUW76_32345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LUW76_32350	COG4941	Belongs to the sigma-70 factor family
LUW76_32375	COG1733	regulation of RNA biosynthetic process
LUW76_32415	COG2084	Dehydrogenase
LUW76_32440	COG2814	Major facilitator Superfamily
LUW76_32465	COG1404	Belongs to the peptidase S8 family
LUW76_32495	COG1695	Transcriptional regulator
LUW76_32510	COG1595	DNA-templated transcription, initiation
LUW76_32525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LUW76_32550	COG0459	protein refolding
LUW76_32585	COG1061	Type III restriction enzyme res subunit
LUW76_32600	COG1309	transcriptional regulator
LUW76_32625	COG2814	Major facilitator Superfamily
LUW76_32655	COG2814	Major facilitator Superfamily
LUW76_32660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LUW76_32705	COG0259	pyridoxamine-phosphate oxidase activity
LUW76_32715	COG1573	uracil-dna glycosylase
LUW76_32735	COG2226	methyltransferase
LUW76_32755	COG0183	Belongs to the thiolase family
LUW76_32760	COG1024	Enoyl-CoA hydratase
LUW76_32790	COG0640	Transcriptional regulator
LUW76_32825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LUW76_32835	COG2197	response regulator
LUW76_32845	COG2409	Drug exporters of the RND superfamily
LUW76_32860	COG2207	Transcriptional regulator
LUW76_32870	COG4585	Histidine kinase
LUW76_32880	COG1131	(ABC) transporter
LUW76_32920	COG1309	transcriptional regulator
LUW76_32940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_32955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_32970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW76_33005	COG1725	Transcriptional regulator
LUW76_33020	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_33040	COG0018	arginyl-trna synthetase
LUW76_33045	COG0416	fatty acid biosynthetic process
LUW76_33085	COG1881	PFAM PEBP family protein
LUW76_33090	COG0395	ABC-type sugar transport system, permease component
LUW76_33095	COG1175	transmembrane transport
LUW76_33100	COG3842	ATPase activity
LUW76_33110	COG1134	teichoic acid transport
LUW76_33110	COG1388	LysM domain
LUW76_33120	COG1597	lipid kinase activity
LUW76_33130	COG2720	vancomycin resistance protein
LUW76_33165	COG0438	transferase activity, transferring glycosyl groups
LUW76_33170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LUW76_33185	COG0181	hydroxymethylbilane synthase activity
LUW76_33215	COG0442	prolyl-tRNA aminoacylation
LUW76_33220	COG0442	prolyl-tRNA aminoacylation
LUW76_33250	COG1595	DNA-templated transcription, initiation
LUW76_33265	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW76_33265	COG2208	phosphoserine phosphatase activity
LUW76_33265	COG2172	sigma factor antagonist activity
LUW76_33305	COG0612	Peptidase, M16
LUW76_33310	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW76_33355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LUW76_33380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LUW76_33385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_33390	COG4941	Belongs to the sigma-70 factor family
LUW76_33435	COG0577	efflux transmembrane transporter activity
LUW76_33435	COG1136	(ABC) transporter
LUW76_33455	COG5564	TIM-barrel signal transduction protein
LUW76_33475	COG1252	NADH dehydrogenase
LUW76_33480	COG1595	DNA-templated transcription, initiation
LUW76_33490	COG3012	SEC-C Motif Domain Protein
LUW76_33510	COG4941	Belongs to the sigma-70 factor family
LUW76_33525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LUW76_33530	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LUW76_33560	COG1309	transcriptional regulator
LUW76_33565	COG0657	acetylesterase activity
LUW76_33570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LUW76_33575	COG0747	negative chemotaxis
LUW76_33580	COG0601	transmembrane transport
LUW76_33585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW76_33590	COG0444	Belongs to the ABC transporter superfamily
LUW76_33595	COG4608	Belongs to the ABC transporter superfamily
LUW76_33600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LUW76_33605	COG1414	Transcriptional regulator
LUW76_33610	COG2080	2 iron, 2 sulfur cluster binding
LUW76_33615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LUW76_33620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW76_33635	COG3384	dioxygenase
LUW76_33645	COG2124	cytochrome p450
LUW76_33650	COG0579	oxidoreductase
LUW76_33660	COG1396	sequence-specific DNA binding
LUW76_33665	COG0477	Major facilitator Superfamily
LUW76_33670	COG1228	amidohydrolase
LUW76_33685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LUW76_33685	COG0515	serine threonine protein kinase
LUW76_33725	COG3344	reverse transcriptase
LUW76_33735	COG0714	Associated with various cellular activities
LUW76_33865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW76_33870	COG0195	Participates in both transcription termination and antitermination
LUW76_33905	COG1876	peptidase activity
LUW76_33910	COG1970	mechanosensitive ion channel activity
LUW76_33920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LUW76_33925	COG2409	Drug exporters of the RND superfamily
LUW76_33935	COG3263	regulation of cellular component size
LUW76_33950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LUW76_33955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LUW76_33965	COG0315	cyclic pyranopterin monophosphate synthase activity
LUW76_33970	COG0521	Mo-molybdopterin cofactor biosynthetic process
LUW76_33975	COG0215	cysteine-tRNA ligase activity
LUW76_33995	COG0477	Major facilitator Superfamily
LUW76_34000	COG3795	YCII-related domain
LUW76_34015	COG2222	sugar isomerase
LUW76_34050	COG0154	amidase activity
LUW76_34075	COG1349	DNA-binding transcription factor activity
LUW76_34095	COG0745	RESPONSE REGULATOR receiver
LUW76_34100	COG2205	protein histidine kinase activity
LUW76_34125	COG1960	acyl-CoA dehydrogenase activity
LUW76_34130	COG0667	Aldo Keto reductase
LUW76_34145	COG0375	protein maturation
LUW76_34155	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LUW76_34195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LUW76_34205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LUW76_34215	COG0409	Hydrogenase expression formation protein
LUW76_34230	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_34230	COG1672	PFAM Archaeal ATPase
LUW76_34250	COG2508	Transcriptional regulator
LUW76_34265	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_34270	COG0300	oxidoreductase activity
LUW76_34275	COG3835	regulator
LUW76_34300	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LUW76_34310	COG1657	PFAM Prenyltransferase squalene oxidase
LUW76_34335	COG1132	(ABC) transporter
LUW76_34340	COG1132	(ABC) transporter
LUW76_34355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LUW76_34365	COG0248	Ppx GppA phosphatase
LUW76_34370	COG0701	Predicted permease
LUW76_34395	COG3485	protocatechuate 3,4-dioxygenase
LUW76_34410	COG0778	Nitroreductase
LUW76_34430	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_34445	COG1063	alcohol dehydrogenase
LUW76_34450	COG1414	Transcriptional regulator
LUW76_34460	COG1024	Enoyl-CoA hydratase
LUW76_34470	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_34475	COG0402	S-adenosylhomocysteine deaminase activity
LUW76_34490	COG3181	Tripartite tricarboxylate transporter family receptor
LUW76_34500	COG0028	Belongs to the TPP enzyme family
LUW76_34505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LUW76_34525	COG2234	aminopeptidase activity
LUW76_34535	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
LUW76_34540	COG0667	Aldo Keto reductase
LUW76_34555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW76_34645	COG2826	transposase and inactivated derivatives, IS30 family
LUW76_34685	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW76_34690	COG0022	dehydrogenase e1 component
LUW76_34705	COG1522	sequence-specific DNA binding
LUW76_34715	COG1802	Transcriptional regulator
LUW76_34725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LUW76_34735	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_34770	COG1473	amidohydrolase
LUW76_34775	COG3547	Transposase (IS116 IS110 IS902 family)
LUW76_34785	COG0745	RESPONSE REGULATOR receiver
LUW76_34790	COG0018	arginyl-trna synthetase
LUW76_34795	COG0019	diaminopimelate decarboxylase activity
LUW76_34800	COG0460	homoserine dehydrogenase
LUW76_34805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LUW76_34810	COG0083	homoserine kinase activity
LUW76_34825	COG2197	response regulator
LUW76_34830	COG0254	rRNA binding
LUW76_34835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LUW76_34860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LUW76_34880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LUW76_34885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LUW76_34890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LUW76_34895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LUW76_34900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LUW76_34905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LUW76_34910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LUW76_34950	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_34970	COG0702	epimerase
LUW76_34980	COG1994	Peptidase M50
LUW76_35030	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LUW76_35050	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_35055	COG1024	Enoyl-CoA hydratase
LUW76_35055	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_35070	COG0628	permease
LUW76_35080	COG0346	lactoylglutathione lyase activity
LUW76_35085	COG0183	Belongs to the thiolase family
LUW76_35100	COG2814	Major facilitator Superfamily
LUW76_35135	COG1678	Uncharacterized ACR, COG1678
LUW76_35160	COG3265	gluconokinase activity
LUW76_35165	COG1335	isochorismatase
LUW76_35175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LUW76_35225	COG1234	tRNA 3'-trailer cleavage
LUW76_35230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LUW76_35235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LUW76_35245	COG1595	DNA-templated transcription, initiation
LUW76_35275	COG0477	Major facilitator Superfamily
LUW76_35300	COG1486	melibiose metabolic process
LUW76_35330	COG0277	FAD linked oxidase domain protein
LUW76_35335	COG1301	dicarboxylic acid transport
LUW76_35340	COG3290	protein histidine kinase activity
LUW76_35345	COG4565	transcriptional regulatory protein
LUW76_35355	COG0183	Belongs to the thiolase family
LUW76_35390	COG1280	lysine exporter protein (LysE YggA)
LUW76_35420	COG1760	l-serine dehydratase
LUW76_35425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LUW76_35430	COG0509	glycine decarboxylation via glycine cleavage system
LUW76_35435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LUW76_35440	COG0750	zinc metalloprotease
LUW76_35445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LUW76_35455	COG1793	dna ligase
LUW76_35480	COG1309	transcriptional regulator
LUW76_35495	COG1309	transcriptional regulator
LUW76_35515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW76_35620	COG1309	transcriptional regulator
LUW76_35635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW76_35640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LUW76_35685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LUW76_35710	COG0204	Acyl-transferase
LUW76_35720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LUW76_35740	COG3634	alkyl hydroperoxide reductase activity
LUW76_35770	COG2508	Transcriptional regulator
LUW76_35770	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LUW76_35775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LUW76_35815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_35820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_35820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LUW76_35835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LUW76_35900	COG0673	inositol 2-dehydrogenase activity
LUW76_35905	COG1116	anion transmembrane transporter activity
LUW76_35915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_35920	COG1609	Transcriptional regulator
LUW76_35975	COG2080	2 iron, 2 sulfur cluster binding
LUW76_35980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LUW76_35985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW76_35990	COG1620	l-lactate permease
LUW76_36040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LUW76_36050	COG1053	succinate dehydrogenase
LUW76_36065	COG0346	lactoylglutathione lyase activity
LUW76_36085	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_36150	COG1960	acyl-CoA dehydrogenase activity
LUW76_36155	COG0583	DNA-binding transcription factor activity
LUW76_36175	COG1309	transcriptional regulator
LUW76_36270	COG0028	Belongs to the TPP enzyme family
LUW76_36285	COG1414	Transcriptional regulator
LUW76_36290	COG3321	synthase
LUW76_36290	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_36290	COG0604	alcohol dehydrogenase
LUW76_36300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LUW76_36315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LUW76_36340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LUW76_36350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LUW76_36360	COG4208	sulfate ABC transporter
LUW76_36370	COG1959	2 iron, 2 sulfur cluster binding
LUW76_36375	COG1595	DNA-templated transcription, initiation
LUW76_36400	COG0438	transferase activity, transferring glycosyl groups
LUW76_36405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_36490	COG2267	carboxylic ester hydrolase activity
LUW76_36530	COG2171	N-acyltransferase activity
LUW76_36540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW76_36545	COG1611	Belongs to the LOG family
LUW76_36555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LUW76_36560	COG1609	Transcriptional regulator
LUW76_36565	COG0583	DNA-binding transcription factor activity
LUW76_36575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW76_36585	COG1131	(ABC) transporter
LUW76_36595	COG3559	Exporter of polyketide antibiotics
LUW76_36600	COG1611	Belongs to the LOG family
LUW76_36605	COG0028	Belongs to the TPP enzyme family
LUW76_36610	COG0483	inositol monophosphate 1-phosphatase activity
LUW76_36640	COG2818	Glycosylase
LUW76_36650	COG0577	efflux transmembrane transporter activity
LUW76_36650	COG1136	(ABC) transporter
LUW76_36655	COG1024	Enoyl-CoA hydratase
LUW76_36665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LUW76_36675	COG4122	O-methyltransferase activity
LUW76_36680	COG1595	DNA-templated transcription, initiation
LUW76_36695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LUW76_36710	COG1846	Transcriptional regulator
LUW76_36720	COG2239	Acts as a magnesium transporter
LUW76_36755	COG0613	PHP domain protein
LUW76_36805	COG4585	Histidine kinase
LUW76_36815	COG2409	Drug exporters of the RND superfamily
LUW76_36900	COG0702	epimerase
LUW76_36905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LUW76_36915	COG0513	Belongs to the DEAD box helicase family
LUW76_36945	COG3285	dna ligase
LUW76_36945	COG1793	dna ligase
LUW76_36950	COG1793	dna ligase
LUW76_36950	COG3285	dna ligase
LUW76_36955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LUW76_36965	COG2409	Drug exporters of the RND superfamily
LUW76_36980	COG5002	protein histidine kinase activity
LUW76_36985	COG0745	RESPONSE REGULATOR receiver
LUW76_36990	COG0475	glutathione-regulated potassium exporter activity
LUW76_37010	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_37050	COG2226	methyltransferase
LUW76_37060	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_37075	COG0019	diaminopimelate decarboxylase activity
LUW76_37090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LUW76_37125	COG1946	Acyl-CoA thioesterase
LUW76_37145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LUW76_37185	COG1615	UPF0182 protein
LUW76_37190	COG1615	UPF0182 protein
LUW76_37195	COG1615	UPF0182 protein
LUW76_37210	COG3480	Lon protease (S16) C-terminal proteolytic domain
LUW76_37220	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_37250	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_37280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_37290	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_37295	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_37305	COG0300	oxidoreductase activity
LUW76_37315	COG1309	transcriptional regulator
LUW76_37340	COG0277	FAD linked oxidase domain protein
LUW76_37350	COG2815	serine threonine protein kinase
LUW76_37350	COG0515	serine threonine protein kinase
LUW76_37360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LUW76_37380	COG2135	peptidase activity
LUW76_37390	COG2226	methyltransferase
LUW76_37395	COG1595	DNA-templated transcription, initiation
LUW76_37400	COG5662	AntiSigma factor
LUW76_37405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LUW76_37410	COG2199	diguanylate cyclase activity
LUW76_37410	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LUW76_37415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LUW76_37415	COG2199	diguanylate cyclase activity
LUW76_37430	COG2124	cytochrome p450
LUW76_37470	COG0277	FAD linked oxidase domain protein
LUW76_37475	COG2205	protein histidine kinase activity
LUW76_37480	COG0745	RESPONSE REGULATOR receiver
LUW76_37495	COG0577	efflux transmembrane transporter activity
LUW76_37495	COG1136	(ABC) transporter
LUW76_37500	COG0577	efflux transmembrane transporter activity
LUW76_37500	COG1136	(ABC) transporter
LUW76_37525	COG0515	serine threonine protein kinase
LUW76_37565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_37650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW76_37655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LUW76_37680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LUW76_37685	COG0583	DNA-binding transcription factor activity
LUW76_37715	COG0439	Biotin carboxylase
LUW76_37735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LUW76_37740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LUW76_37755	COG2188	Transcriptional regulator
LUW76_37760	COG0156	8-amino-7-oxononanoate synthase activity
LUW76_37790	COG2172	sigma factor antagonist activity
LUW76_37810	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_37820	COG0657	acetylesterase activity
LUW76_37825	COG2186	Transcriptional regulator
LUW76_37835	COG1175	transmembrane transport
LUW76_37850	COG4948	Mandelate Racemase Muconate Lactonizing
LUW76_37870	COG2945	thiolester hydrolase activity
LUW76_37870	COG0596	Alpha beta hydrolase
LUW76_37895	COG4585	Histidine kinase
LUW76_37905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LUW76_37910	COG0281	malic enzyme
LUW76_37915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_37920	COG0765	amino acid transport
LUW76_37930	COG0604	alcohol dehydrogenase
LUW76_37935	COG1695	Transcriptional regulator
LUW76_37955	COG0567	Dehydrogenase, E1 component
LUW76_37955	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW76_37965	COG0435	Glutathione S-transferase
LUW76_37980	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_37985	COG1024	Enoyl-CoA hydratase
LUW76_38000	COG2018	Roadblock/LC7 domain
LUW76_38020	COG2018	Roadblock/LC7 domain
LUW76_38040	COG1129	ABC transporter
LUW76_38045	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_38050	COG4213	ABC transporter substrate-binding protein
LUW76_38055	COG0673	inositol 2-dehydrogenase activity
LUW76_38120	COG2226	methyltransferase
LUW76_38130	COG2124	cytochrome p450
LUW76_38140	COG0488	(ABC) transporter
LUW76_38150	COG0183	Belongs to the thiolase family
LUW76_38160	COG2124	cytochrome p450
LUW76_38165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LUW76_38175	COG2124	cytochrome p450
LUW76_38180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_38185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW76_38205	COG3835	regulator
LUW76_38240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LUW76_38245	COG3622	Belongs to the hyi family
LUW76_38250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LUW76_38255	COG4266	Belongs to the allantoicase family
LUW76_38290	COG1309	transcriptional regulator
LUW76_38295	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_38300	COG1960	acyl-CoA dehydrogenase activity
LUW76_38305	COG1960	acyl-CoA dehydrogenase activity
LUW76_38315	COG0076	glutamate decarboxylase activity
LUW76_38320	COG1309	transcriptional regulator
LUW76_38325	COG0477	Major facilitator Superfamily
LUW76_38340	COG3572	ergothioneine biosynthetic process
LUW76_38345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LUW76_38350	COG0121	glutamine amidotransferase
LUW76_38355	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LUW76_38365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LUW76_38380	COG1609	Transcriptional regulator
LUW76_38390	COG1125	glycine betaine transport
LUW76_38390	COG0517	IMP dehydrogenase activity
LUW76_38395	COG1174	glycine betaine transport
LUW76_38440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_38455	COG1136	(ABC) transporter
LUW76_38520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW76_38520	COG3320	Male sterility
LUW76_38535	COG2986	histidine ammonia-lyase
LUW76_38540	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LUW76_38595	COG1228	amidohydrolase
LUW76_38600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LUW76_38605	COG0616	signal peptide processing
LUW76_38630	COG2186	Transcriptional regulator
LUW76_38645	COG0366	Alpha amylase catalytic
LUW76_38650	COG0058	SHG alpha-glucan phosphorylase activity
LUW76_38655	COG1476	TRANSCRIPTIONal
LUW76_38660	COG4585	Histidine kinase
LUW76_38665	COG4279	zinc finger
LUW76_38670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LUW76_38690	COG4221	oxidoreductase activity
LUW76_38720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LUW76_38725	COG0515	serine threonine protein kinase
LUW76_38755	COG0482	sulfurtransferase activity
LUW76_38770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LUW76_38785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LUW76_38795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LUW76_38805	COG5001	Diguanylate cyclase
LUW76_38820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LUW76_38860	COG0473	3-isopropylmalate dehydrogenase activity
LUW76_38865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LUW76_38870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW76_38925	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_38955	COG2409	Drug exporters of the RND superfamily
LUW76_38970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LUW76_38980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LUW76_39005	COG1007	ATP synthesis coupled electron transport
LUW76_39030	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LUW76_39050	COG2149	membrane
LUW76_39055	COG0789	Transcriptional regulator
LUW76_39065	COG1414	Transcriptional regulator
LUW76_39070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LUW76_39075	COG0066	3-isopropylmalate dehydratase activity
LUW76_39085	COG0776	regulation of translation
LUW76_39105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LUW76_39110	COG1181	Belongs to the D-alanine--D-alanine ligase family
LUW76_39150	COG1309	transcriptional regulator
LUW76_39190	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_39205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_39210	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_39255	COG0351	phosphomethylpyrimidine kinase
LUW76_39260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LUW76_39265	COG1461	Dihydroxyacetone kinase
LUW76_39290	COG0742	ribosomal rna small subunit methyltransferase
LUW76_39295	COG0768	penicillin binding
LUW76_39300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LUW76_39310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LUW76_39320	COG0571	ribonuclease III activity
LUW76_39325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LUW76_39330	COG1254	Belongs to the acylphosphatase family
LUW76_39340	COG1196	nuclear chromosome segregation
LUW76_39355	COG3599	regulation of cell shape
LUW76_39375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LUW76_39385	COG0228	four-way junction DNA binding
LUW76_39390	COG1837	Belongs to the UPF0109 family
LUW76_39395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LUW76_39410	COG0335	large ribosomal subunit rRNA binding
LUW76_39415	COG0681	Belongs to the peptidase S26 family
LUW76_39420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LUW76_39440	COG0792	nuclease activity
LUW76_39445	COG4974	Belongs to the 'phage' integrase family
LUW76_39455	COG0052	Belongs to the universal ribosomal protein uS2 family
LUW76_39460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LUW76_39465	COG0528	UMP kinase activity
LUW76_39470	COG0233	cytoplasmic translational termination
LUW76_39475	COG0575	Belongs to the CDS family
LUW76_39485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LUW76_39500	COG1595	DNA-templated transcription, initiation
LUW76_39525	COG0494	nUDIX hydrolase
LUW76_39535	COG1522	sequence-specific DNA binding
LUW76_39540	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_39555	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW76_39560	COG1177	transmembrane transport
LUW76_39565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LUW76_39585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_39605	COG0631	protein serine/threonine phosphatase activity
LUW76_39610	COG0515	serine threonine protein kinase
LUW76_39635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LUW76_39645	COG0596	Alpha beta hydrolase
LUW76_39655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW76_39680	COG2205	protein histidine kinase activity
LUW76_39695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LUW76_39705	COG0596	Alpha beta hydrolase
LUW76_39770	COG0477	Major facilitator Superfamily
LUW76_39780	COG0745	RESPONSE REGULATOR receiver
LUW76_39785	COG2205	protein histidine kinase activity
LUW76_39790	COG3979	chitinase
LUW76_39800	COG0477	Major facilitator Superfamily
LUW76_39805	COG0477	Major facilitator Superfamily
LUW76_39820	COG3851	Histidine kinase
LUW76_39830	COG1309	transcriptional regulator
LUW76_39850	COG1515	deoxyribonuclease V activity
LUW76_39860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LUW76_39860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LUW76_39925	COG4213	ABC transporter substrate-binding protein
LUW76_39935	COG4214	carbohydrate transport
LUW76_39945	COG1940	carbohydrate kinase activity
LUW76_39990	COG0779	Required for maturation of 30S ribosomal subunits
LUW76_40005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LUW76_40015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LUW76_40020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LUW76_40025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LUW76_40040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LUW76_40045	COG1185	polyribonucleotide nucleotidyltransferase activity
LUW76_40050	COG0612	Peptidase, M16
LUW76_40055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LUW76_40060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LUW76_40075	COG1595	DNA-templated transcription, initiation
LUW76_40080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LUW76_40095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LUW76_40110	COG0477	Major facilitator Superfamily
LUW76_40165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LUW76_40180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LUW76_40210	COG1058	Belongs to the CinA family
LUW76_40210	COG1546	Belongs to the CinA family
LUW76_40215	COG1396	sequence-specific DNA binding
LUW76_40220	COG0783	Belongs to the Dps family
LUW76_40235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LUW76_40250	COG0395	ABC-type sugar transport system, permease component
LUW76_40255	COG1175	transmembrane transport
LUW76_40270	COG0653	protein targeting
LUW76_40275	COG1309	transcriptional regulator
LUW76_40285	COG1201	RNA secondary structure unwinding
LUW76_40295	COG0657	acetylesterase activity
LUW76_40305	COG0754	glutathionylspermidine amidase activity
LUW76_40320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LUW76_40325	COG2137	regulation of response to DNA damage stimulus
LUW76_40330	COG1418	mRNA catabolic process
LUW76_40335	COG0584	glycerophosphoryl diester phosphodiesterase
LUW76_40340	COG1073	alpha beta
LUW76_40350	COG0765	amino acid transport
LUW76_40355	COG0765	amino acid transport
LUW76_40360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_40365	COG1126	abc transporter atp-binding protein
LUW76_40370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LUW76_40390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LUW76_40400	COG1309	transcriptional regulator
LUW76_40435	COG0247	lactate metabolic process
LUW76_40440	COG0277	FAD linked oxidase domain protein
LUW76_40445	COG0277	FAD linked oxidase domain protein
LUW76_40450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LUW76_40455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LUW76_40460	COG1228	amidohydrolase
LUW76_40465	COG1307	EDD domain protein, DegV family
LUW76_40490	COG1307	EDD domain protein, DegV family
LUW76_40495	COG1307	EDD domain protein, DegV family
LUW76_40525	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
LUW76_40530	COG0268	Binds directly to 16S ribosomal RNA
LUW76_40535	COG0481	GTPase activity
LUW76_40570	COG1420	regulation of RNA biosynthetic process
LUW76_40575	COG0484	heat shock protein binding
LUW76_40595	COG0537	adenosine 5'-monophosphoramidase activity
LUW76_40605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LUW76_40620	COG2409	Drug exporters of the RND superfamily
LUW76_40625	COG3629	intracellular signal transduction
LUW76_40625	COG3903	Transcriptional regulator
LUW76_40630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LUW76_40645	COG1834	amidinotransferase
LUW76_40650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW76_40665	COG1175	transmembrane transport
LUW76_40675	COG0366	Alpha amylase catalytic
LUW76_40685	COG0789	Transcriptional regulator
LUW76_40705	COG1381	Involved in DNA repair and RecF pathway recombination
LUW76_40710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LUW76_40715	COG1764	response to oxidative stress
LUW76_40740	COG1121	(ABC) transporter
LUW76_40770	COG0423	glycine-tRNA ligase activity
LUW76_40785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW76_40785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW76_40795	COG3387	PFAM Glycoside hydrolase 15-related
LUW76_40800	COG0574	Belongs to the PEP-utilizing enzyme family
LUW76_40800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LUW76_40810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LUW76_40820	COG2223	nitrite transmembrane transporter activity
LUW76_40830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_40835	COG0789	Transcriptional regulator
LUW76_40865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW76_40870	COG0358	DNA primase activity
LUW76_40875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LUW76_40880	COG0393	Putative heavy-metal-binding
LUW76_40890	COG2837	iron assimilation
LUW76_40930	COG1358	cellular component organization or biogenesis
LUW76_40985	COG2111	Na H antiporter
LUW76_40985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LUW76_40990	COG1006	Multisubunit Na H antiporter MnhC subunit
LUW76_41005	COG2212	antiporter activity
LUW76_41010	COG1320	monovalent cation:proton antiporter activity
LUW76_41025	COG4585	Histidine kinase
LUW76_41045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW76_41050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW76_41055	COG1120	ATPase activity
LUW76_41080	COG0559	Belongs to the binding-protein-dependent transport system permease family
LUW76_41105	COG1024	Enoyl-CoA hydratase
LUW76_41120	COG0477	Major facilitator Superfamily
LUW76_41145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LUW76_41165	COG0531	amino acid
LUW76_41170	COG0405	Gamma-glutamyltransferase
LUW76_41185	COG0477	Major facilitator Superfamily
LUW76_41195	COG1937	Protein conserved in bacteria
LUW76_41200	COG0406	alpha-ribazole phosphatase activity
LUW76_41205	COG0686	Belongs to the AlaDH PNT family
LUW76_41215	COG1929	Belongs to the glycerate kinase type-1 family
LUW76_41220	COG2252	PERMEase
LUW76_41245	COG3336	cytochrome c oxidase
LUW76_41250	COG4585	Histidine kinase
LUW76_41255	COG2197	response regulator
LUW76_41275	COG0745	RESPONSE REGULATOR receiver
LUW76_41280	COG2205	protein histidine kinase activity
LUW76_41285	COG2205	protein histidine kinase activity
LUW76_41295	COG1733	regulation of RNA biosynthetic process
LUW76_41350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LUW76_41355	COG0477	Major facilitator Superfamily
LUW76_41360	COG1309	transcriptional regulator
LUW76_41390	COG2124	cytochrome p450
LUW76_41395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LUW76_41400	COG0765	amino acid transport
LUW76_41405	COG1126	abc transporter atp-binding protein
LUW76_41410	COG0174	glutamine synthetase
LUW76_41415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LUW76_41460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LUW76_41470	COG0321	lipoyl(octanoyl) transferase activity
LUW76_41475	COG3340	Belongs to the peptidase S51 family
LUW76_41480	COG1090	epimerase
LUW76_41490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LUW76_41495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LUW76_41500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LUW76_41520	COG0667	Aldo Keto reductase
LUW76_41540	COG0501	Belongs to the peptidase M48B family
LUW76_41550	COG0501	Belongs to the peptidase M48B family
LUW76_41560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LUW76_41570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW76_41575	COG0425	Belongs to the sulfur carrier protein TusA family
LUW76_41585	COG1104	cysteine desulfurase activity
LUW76_41590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LUW76_41595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LUW76_41605	COG1376	ErfK ybiS ycfS ynhG family protein
LUW76_41610	COG0501	Belongs to the peptidase M48B family
LUW76_41625	COG3103	Sh3 type 3 domain protein
LUW76_41625	COG1388	LysM domain
LUW76_41625	COG0791	NLP P60 protein
LUW76_41660	COG3842	ATPase activity
LUW76_41665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LUW76_41670	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW76_41675	COG1177	transmembrane transport
LUW76_41680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LUW76_41690	COG1845	cytochrome c oxidase, subunit III
LUW76_41695	COG2010	Cytochrome c
LUW76_41700	COG0723	plastoquinol--plastocyanin reductase activity
LUW76_41705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW76_41710	COG0438	transferase activity, transferring glycosyl groups
LUW76_41750	COG1022	Amp-dependent synthetase and ligase
LUW76_41775	COG1940	carbohydrate kinase activity
LUW76_41800	COG2197	response regulator
LUW76_41810	COG3220	belongs to the UPF0276 family
LUW76_41825	COG0301	tRNA thio-modification
LUW76_41835	COG0697	spore germination
LUW76_41840	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LUW76_41845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LUW76_41860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LUW76_41870	COG0515	serine threonine protein kinase
LUW76_41870	COG2815	serine threonine protein kinase
LUW76_41875	COG0697	spore germination
LUW76_41880	COG2022	thiamine diphosphate biosynthetic process
LUW76_41905	COG0352	thiamine-phosphate diphosphorylase activity
LUW76_41915	COG2815	serine threonine protein kinase
LUW76_41915	COG0515	serine threonine protein kinase
LUW76_41920	COG1472	Belongs to the glycosyl hydrolase 3 family
LUW76_41930	COG0142	geranyltranstransferase activity
LUW76_41975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_41980	COG2814	Major facilitator Superfamily
LUW76_41990	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LUW76_41995	COG0540	Belongs to the ATCase OTCase family
LUW76_42000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LUW76_42005	COG0505	Belongs to the CarA family
LUW76_42010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LUW76_42015	COG0543	2 iron, 2 sulfur cluster binding
LUW76_42020	COG0167	dihydroorotate dehydrogenase activity
LUW76_42025	COG0284	orotidine-5'-phosphate decarboxylase activity
LUW76_42040	COG1758	RNA polymerase activity
LUW76_42050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LUW76_42070	COG0242	peptide deformylase activity
LUW76_42075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LUW76_42085	COG0671	phosphoesterase, PA-phosphatase related
LUW76_42090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LUW76_42095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LUW76_42110	COG3201	nicotinamide mononucleotide transporter
LUW76_42115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW76_42115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LUW76_42120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LUW76_42125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LUW76_42150	COG3608	succinylglutamate desuccinylase aspartoacylase
LUW76_42150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LUW76_42185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LUW76_42190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LUW76_42205	COG2233	PERMEase
LUW76_42225	COG0726	polysaccharide deacetylase
LUW76_42290	COG0655	NAD(P)H dehydrogenase (quinone) activity
LUW76_42315	COG1309	transcriptional regulator
LUW76_42325	COG1131	(ABC) transporter
LUW76_42335	COG4585	Histidine kinase
LUW76_42340	COG2197	response regulator
LUW76_42350	COG0549	Belongs to the carbamate kinase family
LUW76_42370	COG0751	glycine-tRNA ligase activity
LUW76_42380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LUW76_42385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LUW76_42390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LUW76_42395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LUW76_42400	COG1309	transcriptional regulator
LUW76_42415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_42430	COG0006	proline dipeptidase activity
LUW76_42440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LUW76_42470	COG0714	Associated with various cellular activities
LUW76_42475	COG2001	Belongs to the MraZ family
LUW76_42480	COG0275	rRNA processing
LUW76_42490	COG0768	penicillin binding
LUW76_42500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LUW76_42505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LUW76_42510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LUW76_42520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LUW76_42525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LUW76_42535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LUW76_42540	COG1496	oxidoreductase activity
LUW76_42550	COG1799	cell septum assembly
LUW76_42560	COG3599	regulation of cell shape
LUW76_42575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LUW76_42585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LUW76_42600	COG0587	DNA-directed DNA polymerase activity
LUW76_42620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LUW76_42625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LUW76_42630	COG0384	phenazine biosynthesis protein PhzF
LUW76_42635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LUW76_42640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LUW76_42645	COG0131	Imidazoleglycerol-phosphate dehydratase
LUW76_42655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LUW76_42660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LUW76_42665	COG0107	imidazoleglycerol-phosphate synthase activity
LUW76_42675	COG1960	acyl-CoA dehydrogenase activity
LUW76_42680	COG1960	acyl-CoA dehydrogenase activity
LUW76_42730	COG1278	Cold shock
LUW76_42740	COG0745	RESPONSE REGULATOR receiver
LUW76_42750	COG0134	indole-3-glycerol-phosphate synthase activity
LUW76_42755	COG0133	tryptophan synthase activity
LUW76_42760	COG0159	tryptophan synthase activity
LUW76_42780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LUW76_42800	COG0070	glutamate synthase
LUW76_42800	COG0069	glutamate synthase activity
LUW76_42800	COG0067	glutamate synthase
LUW76_42835	COG0047	phosphoribosylformylglycinamidine synthase activity
LUW76_42920	COG0237	dephospho-CoA kinase activity
LUW76_42925	COG2319	Wd-40 repeat
LUW76_42925	COG5635	Nacht domain
LUW76_42945	COG0483	inositol monophosphate 1-phosphatase activity
LUW76_42960	COG4585	Histidine kinase
LUW76_42965	COG0556	nucleotide-excision repair
LUW76_42995	COG2755	lipolytic protein G-D-S-L family
LUW76_43015	COG2813	Specifically methylates the guanine in position
LUW76_43050	COG2319	Wd-40 repeat
LUW76_43050	COG4249	Peptidase C14 caspase catalytic subunit p20
LUW76_43085	COG0667	Aldo Keto reductase
LUW76_43095	COG2070	2-Nitropropane dioxygenase
LUW76_43110	COG4977	sequence-specific DNA binding
LUW76_43120	COG1126	abc transporter atp-binding protein
LUW76_43125	COG0765	amino acid transport
LUW76_43130	COG0765	amino acid transport
LUW76_43140	COG5285	phytanoyl-CoA dioxygenase
LUW76_43145	COG1917	Cupin 2, conserved barrel domain protein
LUW76_43150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LUW76_43155	COG0456	acetyltransferase
LUW76_43170	COG0504	CTP synthase activity
LUW76_43175	COG0494	nUDIX hydrolase
LUW76_43195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LUW76_43200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LUW76_43220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LUW76_43225	COG1160	GTP binding
LUW76_43265	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LUW76_43290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LUW76_43310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW76_43330	COG0277	FAD linked oxidase domain protein
LUW76_43335	COG0542	response to heat
LUW76_43355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_43430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LUW76_43435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LUW76_43440	COG0583	DNA-binding transcription factor activity
LUW76_43445	COG0477	Major facilitator Superfamily
LUW76_43465	COG1357	PFAM Pentapeptide repeats (8 copies)
LUW76_43475	COG2890	protein-(glutamine-N5) methyltransferase activity
LUW76_43500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LUW76_43515	COG0745	RESPONSE REGULATOR receiver
LUW76_43530	COG0640	Transcriptional regulator
LUW76_43555	COG0586	Pfam SNARE associated Golgi protein
LUW76_43560	COG4585	Histidine kinase
LUW76_43565	COG2197	response regulator
LUW76_43570	COG1063	alcohol dehydrogenase
LUW76_43610	COG2259	Doxx family
LUW76_43635	COG0477	Major facilitator Superfamily
LUW76_43665	COG2318	DinB family
LUW76_43710	COG1846	Transcriptional regulator
LUW76_43720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_43735	COG1595	DNA-templated transcription, initiation
LUW76_43760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LUW76_43780	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_43795	COG1120	ATPase activity
LUW76_43905	COG0776	regulation of translation
LUW76_43955	COG0535	radical SAM domain protein
LUW76_43995	COG2205	protein histidine kinase activity
LUW76_44025	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_44030	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_44045	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LUW76_44060	COG0745	RESPONSE REGULATOR receiver
LUW76_44065	COG2205	protein histidine kinase activity
LUW76_44070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_44085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LUW76_44095	COG0183	Belongs to the thiolase family
LUW76_44100	COG0583	DNA-binding transcription factor activity
LUW76_44115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LUW76_44115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LUW76_44130	COG2188	Transcriptional regulator
LUW76_44160	COG0626	cystathionine gamma-synthase activity
LUW76_44170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LUW76_44175	COG2318	DinB family
LUW76_44200	COG0395	ABC-type sugar transport system, permease component
LUW76_44205	COG3250	beta-galactosidase activity
LUW76_44250	COG1879	ABC-type sugar transport system periplasmic component
LUW76_44255	COG1129	ABC transporter
LUW76_44260	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_44265	COG1063	alcohol dehydrogenase
LUW76_44280	COG4948	Mandelate Racemase Muconate Lactonizing
LUW76_44285	COG0800	Aldolase
LUW76_44345	COG0154	amidase activity
LUW76_44365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LUW76_44390	COG0583	DNA-binding transcription factor activity
LUW76_44395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LUW76_44415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_44435	COG0730	response to heat
LUW76_44440	COG0583	DNA-binding transcription factor activity
LUW76_44455	COG1053	succinate dehydrogenase
LUW76_44455	COG3976	FMN-binding domain protein
LUW76_44460	COG0129	dihydroxy-acid dehydratase activity
LUW76_44465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_44480	COG1414	Transcriptional regulator
LUW76_44490	COG3903	Transcriptional regulator
LUW76_44490	COG3629	intracellular signal transduction
LUW76_44505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW76_44515	COG1024	Enoyl-CoA hydratase
LUW76_44520	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_44555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_44565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_44575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_44590	COG1132	(ABC) transporter
LUW76_44600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LUW76_44605	COG3424	synthase
LUW76_44610	COG1024	Enoyl-CoA hydratase
LUW76_44615	COG1024	Enoyl-CoA hydratase
LUW76_44635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_44645	COG0475	glutathione-regulated potassium exporter activity
LUW76_44650	COG2211	Major facilitator Superfamily
LUW76_44660	COG1278	Cold shock
LUW76_44675	COG0604	alcohol dehydrogenase
LUW76_44680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LUW76_44685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LUW76_44700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LUW76_44705	COG1802	Transcriptional regulator
LUW76_44720	COG0154	amidase activity
LUW76_44755	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_44770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LUW76_44805	COG2197	response regulator
LUW76_44810	COG4585	Histidine kinase
LUW76_44840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LUW76_44845	COG1120	ATPase activity
LUW76_44855	COG2226	methyltransferase
LUW76_44880	COG1309	transcriptional regulator
LUW76_44885	COG1309	transcriptional regulator
LUW76_44890	COG1131	(ABC) transporter
LUW76_44895	COG3559	Exporter of polyketide antibiotics
LUW76_44910	COG1024	Enoyl-CoA hydratase
LUW76_44925	COG1024	Enoyl-CoA hydratase
LUW76_44930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW76_44940	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_44945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LUW76_44950	COG1176	ABC-type spermidine putrescine transport system, permease component I
LUW76_44955	COG1177	transmembrane transport
LUW76_44960	COG3842	ATPase activity
LUW76_44970	COG0596	Alpha beta hydrolase
LUW76_44975	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LUW76_44980	COG0686	Belongs to the AlaDH PNT family
LUW76_44990	COG3693	PFAM glycoside hydrolase, family 10
LUW76_45000	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LUW76_45005	COG2072	flavoprotein involved in K transport
LUW76_45015	COG1172	Belongs to the binding-protein-dependent transport system permease family
LUW76_45020	COG1129	ABC transporter
LUW76_45025	COG1879	ABC-type sugar transport system periplasmic component
LUW76_45065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LUW76_45065	COG0517	IMP dehydrogenase activity
LUW76_45065	COG0617	tRNA 3'-terminal CCA addition
LUW76_45100	COG0589	response to stress
LUW76_45145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LUW76_45165	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_45170	COG2072	flavoprotein involved in K transport
LUW76_45185	COG0633	Ferredoxin
LUW76_45190	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_45205	COG1414	Transcriptional regulator
LUW76_45225	COG0183	Belongs to the thiolase family
LUW76_45270	COG3618	amidohydrolase
LUW76_45275	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_45300	COG3250	beta-galactosidase activity
LUW76_45310	COG1175	transmembrane transport
LUW76_45340	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_45345	COG1960	acyl-CoA dehydrogenase activity
LUW76_45350	COG1960	acyl-CoA dehydrogenase activity
LUW76_45360	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_45380	COG1960	acyl-CoA dehydrogenase activity
LUW76_45385	COG1960	acyl-CoA dehydrogenase activity
LUW76_45435	COG1595	DNA-templated transcription, initiation
LUW76_45440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LUW76_45470	COG2267	carboxylic ester hydrolase activity
LUW76_45475	COG1129	ABC transporter
LUW76_45485	COG1879	ABC-type sugar transport system periplasmic component
LUW76_45510	COG3384	dioxygenase
LUW76_45520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_45545	COG0596	Alpha beta hydrolase
LUW76_45585	COG3795	YCII-related domain
LUW76_45590	COG4941	Belongs to the sigma-70 factor family
LUW76_45625	COG2267	carboxylic ester hydrolase activity
LUW76_45630	COG3328	transposase activity
LUW76_45655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_45675	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_45685	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_45700	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_45725	COG1802	Transcriptional regulator
LUW76_45730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LUW76_45730	COG1116	anion transmembrane transporter activity
LUW76_45740	COG1174	glycine betaine transport
LUW76_45745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LUW76_45770	COG1802	Transcriptional regulator
LUW76_45780	COG1228	amidohydrolase
LUW76_45820	COG1802	Transcriptional regulator
LUW76_45825	COG0179	Fumarylacetoacetate (FAA) hydrolase
LUW76_45840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LUW76_45855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LUW76_45875	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
LUW76_45880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_45885	COG1024	Enoyl-CoA hydratase
LUW76_45905	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_45915	COG2267	carboxylic ester hydrolase activity
LUW76_45935	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_45975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_45985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_45985	COG3433	isochorismatase activity
LUW76_45985	COG2226	methyltransferase
LUW76_46015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LUW76_46015	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LUW76_46015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LUW76_46015	COG3321	synthase
LUW76_46020	COG3634	alkyl hydroperoxide reductase activity
LUW76_46040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_46045	COG2226	methyltransferase
LUW76_46045	COG3433	isochorismatase activity
LUW76_46045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LUW76_46050	COG4106	trans-aconitate 2-methyltransferase activity
LUW76_46060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LUW76_46065	COG0436	Aminotransferase
LUW76_46080	COG0596	Alpha beta hydrolase
LUW76_46090	COG0405	Gamma-glutamyltransferase
LUW76_46150	COG0247	lactate metabolic process
LUW76_46150	COG2181	nitrate reductase activity
LUW76_46155	COG0277	FAD linked oxidase domain protein
LUW76_46170	COG1012	belongs to the aldehyde dehydrogenase family
LUW76_46180	COG3631	Ketosteroid isomerase-related protein
LUW76_46185	COG1960	acyl-CoA dehydrogenase activity
LUW76_46190	COG1960	acyl-CoA dehydrogenase activity
LUW76_46205	COG1984	allophanate hydrolase subunit 2
LUW76_46215	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LUW76_46220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LUW76_46230	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_46245	COG1073	alpha beta
LUW76_46250	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_46255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LUW76_46260	COG0183	Belongs to the thiolase family
LUW76_46265	COG0583	DNA-binding transcription factor activity
LUW76_46280	COG0477	Major facilitator Superfamily
LUW76_46285	COG2376	Dihydroxyacetone kinase
LUW76_46305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LUW76_46335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW76_46345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW76_46360	COG0243	molybdopterin cofactor binding
LUW76_46370	COG0243	molybdopterin cofactor binding
LUW76_46380	COG1191	sigma factor activity
LUW76_46385	COG0248	Ppx GppA phosphatase
LUW76_46390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LUW76_46390	COG0723	plastoquinol--plastocyanin reductase activity
LUW76_46425	COG0154	amidase activity
LUW76_46440	COG0508	dehydrogenase complex catalyzes the overall conversion of
LUW76_46445	COG0022	dehydrogenase e1 component
LUW76_46460	COG0604	alcohol dehydrogenase
LUW76_46470	COG1414	Transcriptional regulator
LUW76_46550	COG1999	signal sequence binding
LUW76_46570	COG2197	response regulator
LUW76_46580	COG1250	3-hydroxyacyl-CoA dehydrogenase
LUW76_46615	COG0604	alcohol dehydrogenase
LUW76_46615	COG3321	synthase
LUW76_46625	COG0604	alcohol dehydrogenase
LUW76_46625	COG3321	synthase
LUW76_46675	COG3629	intracellular signal transduction
LUW76_46675	COG3903	Transcriptional regulator
LUW76_46725	COG0667	Aldo Keto reductase
LUW76_46800	COG2815	serine threonine protein kinase
LUW76_46800	COG0515	serine threonine protein kinase
LUW76_46900	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LUW76_46905	COG1674	ftsk spoiiie
LUW76_46965	COG0582	viral genome integration into host DNA
LUW76_46995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LUW76_47000	COG1960	acyl-CoA dehydrogenase activity
LUW76_47005	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_47010	COG1309	transcriptional regulator
LUW76_47015	COG0183	Belongs to the thiolase family
LUW76_47025	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LUW76_47030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LUW76_47035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LUW76_47045	COG1414	Transcriptional regulator
LUW76_47050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LUW76_47060	COG1802	Transcriptional regulator
LUW76_47065	COG1024	Enoyl-CoA hydratase
LUW76_47070	COG1960	acyl-CoA dehydrogenase activity
LUW76_47085	COG0667	Aldo Keto reductase
LUW76_47110	COG1024	Enoyl-CoA hydratase
LUW76_47115	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_47120	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_47125	COG0515	serine threonine protein kinase
LUW76_47130	COG1643	Atp-dependent helicase
LUW76_47165	COG1119	ATPase activity
LUW76_47180	COG2409	Drug exporters of the RND superfamily
LUW76_47220	COG2084	Dehydrogenase
LUW76_47235	COG2050	protein possibly involved in aromatic compounds catabolism
LUW76_47260	COG1131	(ABC) transporter
LUW76_47265	COG4585	Histidine kinase
LUW76_47270	COG2197	response regulator
LUW76_47280	COG1309	transcriptional regulator
LUW76_47415	COG1028	Short-chain dehydrogenase reductase Sdr
LUW76_47430	COG1129	ABC transporter
LUW76_47435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LUW76_47485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LUW76_47490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LUW76_47515	COG0494	nUDIX hydrolase
LUW76_47530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LUW76_47545	COG2205	protein histidine kinase activity
LUW76_47545	COG0784	Response regulator, receiver
LUW76_47565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LUW76_47575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LUW76_47610	COG2814	Major facilitator Superfamily
LUW76_47635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LUW76_47645	COG0318	PFAM AMP-dependent synthetase and ligase
LUW76_47650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LUW76_47675	COG2124	cytochrome p450
LUW76_47705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LUW76_47710	COG4166	transmembrane transport
LUW76_47715	COG0601	transmembrane transport
LUW76_47720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LUW76_47730	COG4608	Belongs to the ABC transporter superfamily
LUW76_47740	COG0702	epimerase
LUW76_47760	COG2205	protein histidine kinase activity
LUW76_47770	COG2172	sigma factor antagonist activity
LUW76_47775	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW76_47780	COG1366	Belongs to the anti-sigma-factor antagonist family
LUW76_47800	COG1136	(ABC) transporter
LUW76_47800	COG0577	efflux transmembrane transporter activity
LUW76_47830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LUW76_47860	COG0488	(ABC) transporter
LUW76_47870	COG0583	DNA-binding transcription factor activity
LUW76_47895	COG1917	Cupin 2, conserved barrel domain protein
LUW76_47905	COG3844	kynureninase activity
LUW76_47910	COG1278	Cold shock
LUW76_47945	COG2197	response regulator
LUW76_47955	COG4585	Histidine kinase
LUW76_47970	COG0477	Major facilitator Superfamily
LUW76_47975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LUW76_48015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LUW76_48020	COG1560	Kdo2-lipid A biosynthetic process
LUW76_48025	COG0438	transferase activity, transferring glycosyl groups
LUW76_48040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LUW76_48055	COG0217	transcriptional regulatory protein
LUW76_48060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LUW76_48065	COG0632	four-way junction helicase activity
LUW76_48070	COG2255	four-way junction helicase activity
LUW76_48080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW76_48085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LUW76_48090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LUW76_48095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LUW76_48100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LUW76_48105	COG0124	histidyl-tRNA synthetase
LUW76_48120	COG1196	nuclear chromosome segregation
LUW76_48160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LUW76_48170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LUW76_48175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LUW76_48190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LUW76_48200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LUW76_48210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LUW76_48215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LUW76_48225	COG5002	protein histidine kinase activity
LUW76_48230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LUW76_48245	COG1672	PFAM Archaeal ATPase
LUW76_48245	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LUW76_48275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LUW76_48280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LUW76_48285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LUW76_48290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LUW76_48300	COG1438	arginine binding
LUW76_48305	COG0165	Argininosuccinate lyase
LUW76_48310	COG2094	Belongs to the DNA glycosylase MPG family
LUW76_48320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)