locus-tag	class	description
HUT06_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUT06_00010	COG0592	DNA-directed DNA polymerase activity
HUT06_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT06_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT06_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUT06_00030	COG0187	DNA topoisomerase II activity
HUT06_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT06_00040	COG3266	domain, Protein
HUT06_00075	COG0697	spore germination
HUT06_00085	COG0300	oxidoreductase activity
HUT06_00110	COG0640	Transcriptional regulator
HUT06_00140	COG1294	oxidase, subunit
HUT06_00145	COG1271	oxidase subunit
HUT06_00155	COG0151	Belongs to the GarS family
HUT06_00165	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT06_00170	COG1834	amidinotransferase
HUT06_00220	COG0513	Belongs to the DEAD box helicase family
HUT06_00240	COG0705	Rhomboid family
HUT06_00255	COG3764	Sortase (surface protein transpeptidase)
HUT06_00265	COG0515	serine threonine protein kinase
HUT06_00270	COG0515	serine threonine protein kinase
HUT06_00275	COG0768	penicillin binding
HUT06_00290	COG1716	ATPase activity
HUT06_00350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT06_00415	COG2378	regulation of single-species biofilm formation
HUT06_00455	COG3467	pyridoxamine 5'-phosphate
HUT06_00465	COG2814	Major facilitator Superfamily
HUT06_00475	COG4221	oxidoreductase activity
HUT06_00535	COG0477	Major facilitator Superfamily
HUT06_00575	COG1733	regulation of RNA biosynthetic process
HUT06_00620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT06_00685	COG0583	DNA-binding transcription factor activity
HUT06_00690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT06_00700	COG1309	transcriptional regulator
HUT06_00715	COG1595	DNA-templated transcription, initiation
HUT06_00735	COG1902	pentaerythritol trinitrate reductase activity
HUT06_00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT06_00815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT06_00825	COG5002	protein histidine kinase activity
HUT06_00835	COG2235	arginine
HUT06_00870	COG0745	RESPONSE REGULATOR receiver
HUT06_00875	COG5002	protein histidine kinase activity
HUT06_00900	COG5650	phosphatidylinositol metabolic process
HUT06_00915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT06_00930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT06_00935	COG0561	phosphatase activity
HUT06_00945	COG0604	alcohol dehydrogenase
HUT06_01025	COG1595	DNA-templated transcription, initiation
HUT06_01030	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_01065	COG4585	Histidine kinase
HUT06_01070	COG2197	response regulator
HUT06_01075	COG0515	serine threonine protein kinase
HUT06_01080	COG0783	Belongs to the Dps family
HUT06_01085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT06_01090	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT06_01095	COG2080	2 iron, 2 sulfur cluster binding
HUT06_01105	COG1595	DNA-templated transcription, initiation
HUT06_01115	COG0604	alcohol dehydrogenase
HUT06_01125	COG1131	(ABC) transporter
HUT06_01135	COG0745	RESPONSE REGULATOR receiver
HUT06_01140	COG2205	protein histidine kinase activity
HUT06_01145	COG2814	Major facilitator Superfamily
HUT06_01155	COG1595	DNA-templated transcription, initiation
HUT06_01195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT06_01255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_01365	COG3693	PFAM glycoside hydrolase, family 10
HUT06_01370	COG0667	Aldo Keto reductase
HUT06_01450	COG3920	Histidine kinase
HUT06_01455	COG2207	Transcriptional regulator
HUT06_01485	COG1401	restriction endodeoxyribonuclease activity
HUT06_01495	COG2319	Wd-40 repeat
HUT06_01495	COG4249	Peptidase C14 caspase catalytic subunit p20
HUT06_01510	COG3920	Histidine kinase
HUT06_01530	COG1595	DNA-templated transcription, initiation
HUT06_01560	COG1959	2 iron, 2 sulfur cluster binding
HUT06_01565	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_01575	COG1584	GPR1 FUN34 yaaH family protein
HUT06_01580	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_01585	COG2267	carboxylic ester hydrolase activity
HUT06_01590	COG2205	protein histidine kinase activity
HUT06_01595	COG0745	RESPONSE REGULATOR receiver
HUT06_01615	COG0514	ATP-dependent DNA helicase (RecQ)
HUT06_01620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT06_01630	COG1950	PFAM Membrane protein of
HUT06_01655	COG1253	flavin adenine dinucleotide binding
HUT06_01660	COG1253	flavin adenine dinucleotide binding
HUT06_01670	COG0515	serine threonine protein kinase
HUT06_01675	COG0675	Transposase, IS605 OrfB family
HUT06_01700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_01710	COG0204	Acyl-transferase
HUT06_01710	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_01725	COG2268	Band 7 protein
HUT06_01740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT06_01750	COG1846	Transcriptional regulator
HUT06_01755	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT06_01760	COG0667	Aldo Keto reductase
HUT06_01775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT06_01785	COG0633	Ferredoxin
HUT06_01785	COG3217	Mosc domain protein beta barrel domain protein
HUT06_01790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT06_01795	COG0151	Belongs to the GarS family
HUT06_01800	COG0598	Magnesium transport protein CorA
HUT06_01810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT06_01845	COG0586	Pfam SNARE associated Golgi protein
HUT06_01855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUT06_01870	COG1432	Conserved Protein
HUT06_01895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUT06_01905	COG1846	Transcriptional regulator
HUT06_01945	COG0542	response to heat
HUT06_01950	COG0789	Transcriptional regulator
HUT06_01955	COG0484	heat shock protein binding
HUT06_01960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUT06_01965	COG0443	Heat shock 70 kDa protein
HUT06_01980	COG2197	response regulator
HUT06_01985	COG4585	Histidine kinase
HUT06_01995	COG1404	Belongs to the peptidase S8 family
HUT06_02000	COG1595	DNA-templated transcription, initiation
HUT06_02010	COG1595	DNA-templated transcription, initiation
HUT06_02025	COG0477	Major facilitator Superfamily
HUT06_02030	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT06_02035	COG0183	Belongs to the thiolase family
HUT06_02055	COG2181	nitrate reductase activity
HUT06_02055	COG0247	lactate metabolic process
HUT06_02060	COG3903	Transcriptional regulator
HUT06_02060	COG3629	intracellular signal transduction
HUT06_02080	COG4176	ABC-type proline glycine betaine transport system permease component
HUT06_02090	COG0717	Belongs to the dCTP deaminase family
HUT06_02175	COG0494	nUDIX hydrolase
HUT06_02245	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HUT06_02300	COG1595	DNA-templated transcription, initiation
HUT06_02325	COG2814	Major facilitator Superfamily
HUT06_02345	COG1136	(ABC) transporter
HUT06_02370	COG3304	Inner membrane component domain
HUT06_02375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUT06_02380	COG0726	polysaccharide deacetylase
HUT06_02385	COG1982	Orn Lys Arg decarboxylase major
HUT06_02400	COG1285	pathogenesis
HUT06_02420	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HUT06_02435	COG5002	protein histidine kinase activity
HUT06_02435	COG3850	Histidine kinase
HUT06_02450	COG1316	TRANSCRIPTIONal
HUT06_02455	COG4977	sequence-specific DNA binding
HUT06_02475	COG0242	peptide deformylase activity
HUT06_02530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT06_02535	COG0028	Belongs to the TPP enzyme family
HUT06_02570	COG2188	Transcriptional regulator
HUT06_02585	COG3547	Transposase (IS116 IS110 IS902 family)
HUT06_02600	COG2207	Transcriptional regulator
HUT06_02655	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT06_02690	COG4172	Belongs to the ABC transporter superfamily
HUT06_02700	COG0601	transmembrane transport
HUT06_02740	COG1090	epimerase
HUT06_02745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT06_02750	COG0542	response to heat
HUT06_02765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HUT06_02775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT06_02780	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT06_02785	COG3396	Phenylacetate-CoA oxygenase
HUT06_02790	COG3460	Phenylacetate-CoA oxygenase
HUT06_02795	COG3396	Phenylacetate-CoA oxygenase
HUT06_02800	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_02800	COG2030	dehydratase
HUT06_02805	COG1309	transcriptional regulator
HUT06_02850	COG1742	UPF0060 membrane protein
HUT06_02855	COG0789	Transcriptional regulator
HUT06_02860	COG2837	iron assimilation
HUT06_02875	COG3401	FG-GAP repeat protein
HUT06_02890	COG1473	amidohydrolase
HUT06_02895	COG2860	membrane
HUT06_02915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT06_02940	COG3119	arylsulfatase activity
HUT06_02975	COG1024	Enoyl-CoA hydratase
HUT06_02980	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_02990	COG3976	FMN-binding domain protein
HUT06_02990	COG1053	succinate dehydrogenase
HUT06_03035	COG2197	response regulator
HUT06_03040	COG4585	Histidine kinase
HUT06_03045	COG2409	Drug exporters of the RND superfamily
HUT06_03095	COG0791	NLP P60 protein
HUT06_03095	COG3883	PFAM NLP P60 protein
HUT06_03110	COG0667	Aldo Keto reductase
HUT06_03115	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_03115	COG3321	synthase
HUT06_03115	COG0604	alcohol dehydrogenase
HUT06_03130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_03150	COG0574	Belongs to the PEP-utilizing enzyme family
HUT06_03150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT06_03180	COG1024	Enoyl-CoA hydratase
HUT06_03185	COG4585	Histidine kinase
HUT06_03190	COG2197	response regulator
HUT06_03200	COG0577	efflux transmembrane transporter activity
HUT06_03200	COG1136	(ABC) transporter
HUT06_03210	COG3903	Transcriptional regulator
HUT06_03210	COG3629	intracellular signal transduction
HUT06_03240	COG0477	Major facilitator Superfamily
HUT06_03255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT06_03260	COG1234	tRNA 3'-trailer cleavage
HUT06_03285	COG2309	aminopeptidase activity
HUT06_03290	COG0596	Alpha beta hydrolase
HUT06_03295	COG1802	Transcriptional regulator
HUT06_03300	COG1335	isochorismatase
HUT06_03320	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_03335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_03340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT06_03405	COG3328	transposase activity
HUT06_03420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT06_03440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUT06_03440	COG1754	DNA topoisomerase type I activity
HUT06_03445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT06_03450	COG0470	DNA polymerase III
HUT06_03465	COG1595	DNA-templated transcription, initiation
HUT06_03475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT06_03495	COG1774	PSP1 C-terminal conserved region
HUT06_03500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT06_03500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT06_03540	COG0577	efflux transmembrane transporter activity
HUT06_03540	COG1136	(ABC) transporter
HUT06_03545	COG1136	(ABC) transporter
HUT06_03545	COG0577	efflux transmembrane transporter activity
HUT06_03575	COG0477	Major facilitator Superfamily
HUT06_03600	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HUT06_03610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT06_03630	COG0438	transferase activity, transferring glycosyl groups
HUT06_03655	COG0492	ferredoxin-NADP+ reductase activity
HUT06_03720	COG1846	Transcriptional regulator
HUT06_03740	COG2226	methyltransferase
HUT06_03775	COG1802	Transcriptional regulator
HUT06_03780	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_03785	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_03800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT06_03820	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_03830	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HUT06_03845	COG1113	amino acid transport
HUT06_03855	COG0584	glycerophosphoryl diester phosphodiesterase
HUT06_03860	COG0583	DNA-binding transcription factor activity
HUT06_03865	COG2205	protein histidine kinase activity
HUT06_03895	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_03900	COG0583	DNA-binding transcription factor activity
HUT06_03930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_03980	COG0556	nucleotide-excision repair
HUT06_04005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT06_04020	COG1309	transcriptional regulator
HUT06_04025	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_04045	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_04080	COG1879	ABC-type sugar transport system periplasmic component
HUT06_04090	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_04095	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_04100	COG0515	serine threonine protein kinase
HUT06_04100	COG2815	serine threonine protein kinase
HUT06_04125	COG3540	Alkaline phosphatase
HUT06_04190	COG0577	efflux transmembrane transporter activity
HUT06_04190	COG1136	(ABC) transporter
HUT06_04200	COG0583	DNA-binding transcription factor activity
HUT06_04210	COG1595	DNA-templated transcription, initiation
HUT06_04280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUT06_04290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT06_04320	COG4977	sequence-specific DNA binding
HUT06_04335	COG0737	Belongs to the 5'-nucleotidase family
HUT06_04345	COG1960	acyl-CoA dehydrogenase activity
HUT06_04350	COG1024	Enoyl-CoA hydratase
HUT06_04360	COG1960	acyl-CoA dehydrogenase activity
HUT06_04375	COG2197	response regulator
HUT06_04400	COG3275	phosphorelay sensor kinase activity
HUT06_04415	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT06_04425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT06_04440	COG0673	inositol 2-dehydrogenase activity
HUT06_04445	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUT06_04455	COG0438	transferase activity, transferring glycosyl groups
HUT06_04480	COG0463	Glycosyl transferase, family 2
HUT06_04495	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_04500	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_04510	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_04515	COG1414	Transcriptional regulator
HUT06_04545	COG0583	DNA-binding transcription factor activity
HUT06_04565	COG1063	alcohol dehydrogenase
HUT06_04585	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT06_04605	COG2409	Drug exporters of the RND superfamily
HUT06_04615	COG1140	nitrate reductase beta subunit
HUT06_04635	COG1131	(ABC) transporter
HUT06_04645	COG4585	Histidine kinase
HUT06_04650	COG2197	response regulator
HUT06_04655	COG1309	transcriptional regulator
HUT06_04660	COG2409	Drug exporters of the RND superfamily
HUT06_04665	COG2197	response regulator
HUT06_04670	COG4585	Histidine kinase
HUT06_04680	COG0577	efflux transmembrane transporter activity
HUT06_04680	COG1136	(ABC) transporter
HUT06_04690	COG0531	amino acid
HUT06_04805	COG2267	carboxylic ester hydrolase activity
HUT06_04825	COG1960	acyl-CoA dehydrogenase activity
HUT06_04835	COG3976	FMN-binding domain protein
HUT06_04835	COG1053	succinate dehydrogenase
HUT06_04840	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_04850	COG1053	succinate dehydrogenase
HUT06_04860	COG1053	succinate dehydrogenase
HUT06_04895	COG4941	Belongs to the sigma-70 factor family
HUT06_04900	COG3795	YCII-related domain
HUT06_04960	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_04970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_04975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUT06_04985	COG0183	Belongs to the thiolase family
HUT06_04990	COG0583	DNA-binding transcription factor activity
HUT06_05010	COG0124	histidyl-tRNA synthetase
HUT06_05050	COG1131	(ABC) transporter
HUT06_05060	COG0747	negative chemotaxis
HUT06_05065	COG0601	transmembrane transport
HUT06_05080	COG0488	(ABC) transporter
HUT06_05110	COG2409	Drug exporters of the RND superfamily
HUT06_05115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUT06_05120	COG4585	Histidine kinase
HUT06_05125	COG2197	response regulator
HUT06_05130	COG0577	efflux transmembrane transporter activity
HUT06_05130	COG1136	(ABC) transporter
HUT06_05180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT06_05180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT06_05185	COG2409	Drug exporters of the RND superfamily
HUT06_05190	COG4585	Histidine kinase
HUT06_05200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT06_05220	COG2018	Roadblock/LC7 domain
HUT06_05240	COG0587	DNA-directed DNA polymerase activity
HUT06_05255	COG3850	Histidine kinase
HUT06_05255	COG0642	Histidine kinase
HUT06_05265	COG0745	RESPONSE REGULATOR receiver
HUT06_05270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT06_05285	COG0745	RESPONSE REGULATOR receiver
HUT06_05290	COG0745	RESPONSE REGULATOR receiver
HUT06_05305	COG0714	Associated with various cellular activities
HUT06_05395	COG0475	glutathione-regulated potassium exporter activity
HUT06_05430	COG2207	Transcriptional regulator
HUT06_05440	COG1162	GTPase activity
HUT06_05475	COG2197	response regulator
HUT06_05480	COG4585	Histidine kinase
HUT06_05485	COG1131	(ABC) transporter
HUT06_05520	COG1131	(ABC) transporter
HUT06_05560	COG2197	response regulator
HUT06_05565	COG1902	pentaerythritol trinitrate reductase activity
HUT06_05575	COG2723	6-phospho-beta-galactosidase activity
HUT06_05600	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_05610	COG1024	Enoyl-CoA hydratase
HUT06_05650	COG0456	acetyltransferase
HUT06_05655	COG0737	Belongs to the 5'-nucleotidase family
HUT06_05660	COG0306	phosphate transporter
HUT06_05675	COG0464	growth
HUT06_05690	COG0242	peptide deformylase activity
HUT06_05695	COG0745	RESPONSE REGULATOR receiver
HUT06_05700	COG2205	protein histidine kinase activity
HUT06_05705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT06_05715	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT06_05720	COG0745	RESPONSE REGULATOR receiver
HUT06_05785	COG1404	Belongs to the peptidase S8 family
HUT06_05795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT06_05830	COG1674	ftsk spoiiie
HUT06_05850	COG4842	Belongs to the WXG100 family
HUT06_05855	COG4842	Belongs to the WXG100 family
HUT06_05905	COG1316	TRANSCRIPTIONal
HUT06_05910	COG1216	Glycosyl transferase, family 2
HUT06_05920	COG1216	Glycosyl transferase, family 2
HUT06_05935	COG1216	Glycosyl transferase, family 2
HUT06_05960	COG3119	arylsulfatase activity
HUT06_06030	COG3442	glutamine amidotransferase
HUT06_06085	COG2318	DinB family
HUT06_06105	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HUT06_06125	COG1490	D-aminoacyl-tRNA deacylase activity
HUT06_06130	COG3246	L-lysine catabolic process to acetate
HUT06_06145	COG2807	transmembrane transport
HUT06_06150	COG2186	Transcriptional regulator
HUT06_06185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT06_06190	COG1309	transcriptional regulator
HUT06_06195	COG2409	Drug exporters of the RND superfamily
HUT06_06205	COG1755	Isoprenylcysteine carboxyl methyltransferase
HUT06_06230	COG0667	Aldo Keto reductase
HUT06_06245	COG2130	NADP-dependent
HUT06_06270	COG3328	transposase activity
HUT06_06290	COG0778	Nitroreductase
HUT06_06295	COG5650	phosphatidylinositol metabolic process
HUT06_06305	COG2197	response regulator
HUT06_06330	COG0180	Tryptophanyl-tRNA synthetase
HUT06_06335	COG1309	transcriptional regulator
HUT06_06340	COG2226	methyltransferase
HUT06_06355	COG3384	dioxygenase
HUT06_06365	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HUT06_06400	COG0438	transferase activity, transferring glycosyl groups
HUT06_06410	COG0588	phosphoglycerate mutase activity
HUT06_06430	COG1309	transcriptional regulator
HUT06_06450	COG0745	RESPONSE REGULATOR receiver
HUT06_06470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUT06_06475	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_06500	COG4941	Belongs to the sigma-70 factor family
HUT06_06505	COG0596	Alpha beta hydrolase
HUT06_06510	COG0215	cysteine-tRNA ligase activity
HUT06_06515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT06_06520	COG0697	spore germination
HUT06_06525	COG4941	Belongs to the sigma-70 factor family
HUT06_06560	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_06565	COG1671	Belongs to the UPF0178 family
HUT06_06590	COG2205	protein histidine kinase activity
HUT06_06605	COG0477	Major facilitator Superfamily
HUT06_06620	COG2261	transglycosylase associated protein
HUT06_06635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT06_06670	COG1695	Transcriptional regulator
HUT06_06675	COG0515	serine threonine protein kinase
HUT06_06680	COG1595	DNA-templated transcription, initiation
HUT06_06690	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT06_06695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUT06_06735	COG0459	protein refolding
HUT06_06780	COG1061	Type III restriction enzyme res subunit
HUT06_06785	COG0640	Transcriptional regulator
HUT06_06805	COG1309	transcriptional regulator
HUT06_06825	COG1278	Cold shock
HUT06_06830	COG2814	Major facilitator Superfamily
HUT06_06855	COG2814	Major facilitator Superfamily
HUT06_06860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HUT06_06905	COG0259	pyridoxamine-phosphate oxidase activity
HUT06_06915	COG1573	uracil-dna glycosylase
HUT06_06935	COG2226	methyltransferase
HUT06_06955	COG0183	Belongs to the thiolase family
HUT06_06960	COG1024	Enoyl-CoA hydratase
HUT06_06965	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_06975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_07000	COG0583	DNA-binding transcription factor activity
HUT06_07085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_07090	COG1672	PFAM Archaeal ATPase
HUT06_07090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT06_07095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT06_07120	COG1725	Transcriptional regulator
HUT06_07150	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_07155	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_07175	COG0018	arginyl-trna synthetase
HUT06_07180	COG0416	fatty acid biosynthetic process
HUT06_07220	COG1881	PFAM PEBP family protein
HUT06_07225	COG0395	ABC-type sugar transport system, permease component
HUT06_07230	COG1175	transmembrane transport
HUT06_07235	COG3842	ATPase activity
HUT06_07245	COG1388	LysM domain
HUT06_07245	COG1134	teichoic acid transport
HUT06_07255	COG1597	lipid kinase activity
HUT06_07260	COG2720	vancomycin resistance protein
HUT06_07290	COG0438	transferase activity, transferring glycosyl groups
HUT06_07295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT06_07320	COG0488	(ABC) transporter
HUT06_07330	COG0442	prolyl-tRNA aminoacylation
HUT06_07335	COG0442	prolyl-tRNA aminoacylation
HUT06_07365	COG1595	DNA-templated transcription, initiation
HUT06_07405	COG0612	Peptidase, M16
HUT06_07410	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT06_07445	COG1695	Transcriptional regulator
HUT06_07455	COG0464	growth
HUT06_07460	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUT06_07470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT06_07485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT06_07490	COG4941	Belongs to the sigma-70 factor family
HUT06_07495	COG3795	YCII-related domain
HUT06_07525	COG1136	(ABC) transporter
HUT06_07530	COG1136	(ABC) transporter
HUT06_07545	COG5564	TIM-barrel signal transduction protein
HUT06_07550	COG1917	Cupin 2, conserved barrel domain protein
HUT06_07555	COG3012	SEC-C Motif Domain Protein
HUT06_07570	COG4941	Belongs to the sigma-70 factor family
HUT06_07585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUT06_07590	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUT06_07595	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUT06_07650	COG3842	ATPase activity
HUT06_07670	COG2197	response regulator
HUT06_07675	COG0596	Alpha beta hydrolase
HUT06_07680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT06_07685	COG0549	Belongs to the carbamate kinase family
HUT06_07690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT06_07700	COG0531	amino acid
HUT06_07705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT06_07710	COG1595	DNA-templated transcription, initiation
HUT06_07715	COG2197	response regulator
HUT06_07750	COG1876	peptidase activity
HUT06_07765	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT06_07770	COG2409	Drug exporters of the RND superfamily
HUT06_07780	COG3263	regulation of cellular component size
HUT06_07785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT06_07790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT06_07800	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT06_07805	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUT06_07840	COG2205	protein histidine kinase activity
HUT06_07860	COG0745	RESPONSE REGULATOR receiver
HUT06_07865	COG1131	(ABC) transporter
HUT06_07900	COG1349	DNA-binding transcription factor activity
HUT06_07905	COG0215	cysteine-tRNA ligase activity
HUT06_07920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT06_07930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_07945	COG1335	isochorismatase
HUT06_07965	COG0701	Predicted permease
HUT06_08015	COG0222	ribosome binding
HUT06_08020	COG1960	acyl-CoA dehydrogenase activity
HUT06_08025	COG0667	Aldo Keto reductase
HUT06_08035	COG0375	protein maturation
HUT06_08045	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HUT06_08080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT06_08090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT06_08130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_08165	COG3385	transposase activity
HUT06_08170	COG2255	four-way junction helicase activity
HUT06_08185	COG0457	Tetratricopeptide repeat
HUT06_08215	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_08290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_08300	COG2815	serine threonine protein kinase
HUT06_08300	COG0515	serine threonine protein kinase
HUT06_08315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUT06_08340	COG0583	DNA-binding transcription factor activity
HUT06_08350	COG0477	Major facilitator Superfamily
HUT06_08355	COG2367	Beta-lactamase
HUT06_08360	COG0598	Magnesium transport protein CorA
HUT06_08410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT06_08415	COG0084	hydrolase, TatD family'
HUT06_08420	COG0741	lytic transglycosylase activity
HUT06_08425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT06_08435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUT06_08450	COG0488	(ABC) transporter
HUT06_08455	COG0154	amidase activity
HUT06_08460	COG1846	Transcriptional regulator
HUT06_08465	COG4106	trans-aconitate 2-methyltransferase activity
HUT06_08470	COG1309	transcriptional regulator
HUT06_08485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT06_08490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT06_08495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUT06_08500	COG0193	aminoacyl-tRNA hydrolase activity
HUT06_08510	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUT06_08595	COG0730	response to heat
HUT06_08600	COG0529	Catalyzes the synthesis of activated sulfate
HUT06_08640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT06_08645	COG0604	alcohol dehydrogenase
HUT06_08645	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_08645	COG3321	synthase
HUT06_08660	COG5002	protein histidine kinase activity
HUT06_08680	COG0148	phosphopyruvate hydratase activity
HUT06_08710	COG1252	NADH dehydrogenase
HUT06_08730	COG0183	Belongs to the thiolase family
HUT06_08735	COG2755	lipolytic protein G-D-S-L family
HUT06_08745	COG2409	Drug exporters of the RND superfamily
HUT06_08770	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HUT06_08780	COG1940	carbohydrate kinase activity
HUT06_08785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT06_08795	COG0308	aminopeptidase N
HUT06_08800	COG1714	RDD family
HUT06_08810	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT06_08820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT06_08830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT06_08850	COG1234	tRNA 3'-trailer cleavage
HUT06_08855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT06_08860	COG1331	Highly conserved protein containing a thioredoxin domain
HUT06_08870	COG1309	transcriptional regulator
HUT06_08875	COG0477	Major facilitator Superfamily
HUT06_08885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT06_08890	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUT06_08900	COG0114	fumarate hydratase activity
HUT06_08910	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT06_08910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT06_08925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT06_08970	COG1722	exodeoxyribonuclease VII activity
HUT06_08975	COG1570	exodeoxyribonuclease VII activity
HUT06_08990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT06_09000	COG1322	Protein conserved in bacteria
HUT06_09005	COG0012	GTP binding
HUT06_09055	COG0494	nUDIX hydrolase
HUT06_09060	COG0791	NLP P60 protein
HUT06_09060	COG3883	PFAM NLP P60 protein
HUT06_09080	COG0542	response to heat
HUT06_09090	COG0515	serine threonine protein kinase
HUT06_09090	COG2815	serine threonine protein kinase
HUT06_09190	COG1316	TRANSCRIPTIONal
HUT06_09195	COG0515	serine threonine protein kinase
HUT06_09195	COG2815	serine threonine protein kinase
HUT06_09225	COG1053	succinate dehydrogenase
HUT06_09240	COG0583	DNA-binding transcription factor activity
HUT06_09245	COG0010	Belongs to the arginase family
HUT06_09250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT06_09255	COG1053	succinate dehydrogenase
HUT06_09270	COG1132	(ABC) transporter
HUT06_09275	COG1132	(ABC) transporter
HUT06_09290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT06_09310	COG1316	TRANSCRIPTIONal
HUT06_09315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT06_09325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT06_09345	COG1309	transcriptional regulator
HUT06_09355	COG2255	four-way junction helicase activity
HUT06_09375	COG2205	protein histidine kinase activity
HUT06_09380	COG0745	RESPONSE REGULATOR receiver
HUT06_09420	COG1136	(ABC) transporter
HUT06_09420	COG0577	efflux transmembrane transporter activity
HUT06_09485	COG0215	cysteine-tRNA ligase activity
HUT06_09490	COG2226	methyltransferase
HUT06_09500	COG1024	Enoyl-CoA hydratase
HUT06_09555	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUT06_09565	COG1960	acyl-CoA dehydrogenase activity
HUT06_09570	COG0028	Belongs to the TPP enzyme family
HUT06_09580	COG1136	(ABC) transporter
HUT06_09590	COG2205	protein histidine kinase activity
HUT06_09595	COG0745	RESPONSE REGULATOR receiver
HUT06_09600	COG0326	Molecular chaperone. Has ATPase activity
HUT06_09610	COG4977	sequence-specific DNA binding
HUT06_09630	COG0640	Transcriptional regulator
HUT06_09635	COG0515	serine threonine protein kinase
HUT06_09640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUT06_09705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT06_09745	COG0438	transferase activity, transferring glycosyl groups
HUT06_09750	COG0789	Transcriptional regulator
HUT06_09750	COG4978	Transcriptional regulator
HUT06_09760	COG2171	N-acyltransferase activity
HUT06_09780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT06_09785	COG1611	Belongs to the LOG family
HUT06_09840	COG4948	Mandelate Racemase Muconate Lactonizing
HUT06_09855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT06_09860	COG1309	transcriptional regulator
HUT06_09865	COG1131	(ABC) transporter
HUT06_09870	COG3559	Exporter of polyketide antibiotics
HUT06_09875	COG1611	Belongs to the LOG family
HUT06_09880	COG0028	Belongs to the TPP enzyme family
HUT06_09885	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_09895	COG0673	inositol 2-dehydrogenase activity
HUT06_09915	COG1177	transmembrane transport
HUT06_09920	COG3842	ATPase activity
HUT06_09935	COG0561	phosphatase activity
HUT06_09945	COG1609	Transcriptional regulator
HUT06_09955	COG2188	Transcriptional regulator
HUT06_09960	COG1082	Xylose isomerase domain protein TIM barrel
HUT06_09965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT06_09975	COG3962	Belongs to the TPP enzyme family
HUT06_10005	COG2818	Glycosylase
HUT06_10015	COG1136	(ABC) transporter
HUT06_10015	COG0577	efflux transmembrane transporter activity
HUT06_10020	COG1024	Enoyl-CoA hydratase
HUT06_10030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT06_10045	COG1595	DNA-templated transcription, initiation
HUT06_10060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT06_10065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT06_10075	COG1846	Transcriptional regulator
HUT06_10085	COG2239	Acts as a magnesium transporter
HUT06_10120	COG0613	PHP domain protein
HUT06_10145	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_10150	COG0277	FAD linked oxidase domain protein
HUT06_10170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUT06_10180	COG0513	Belongs to the DEAD box helicase family
HUT06_10215	COG1793	dna ligase
HUT06_10215	COG3285	dna ligase
HUT06_10220	COG1793	dna ligase
HUT06_10220	COG3285	dna ligase
HUT06_10225	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT06_10235	COG2409	Drug exporters of the RND superfamily
HUT06_10240	COG2409	Drug exporters of the RND superfamily
HUT06_10250	COG1940	carbohydrate kinase activity
HUT06_10265	COG2201	protein-glutamate methylesterase activity
HUT06_10300	COG1404	Belongs to the peptidase S8 family
HUT06_10310	COG0210	DNA helicase
HUT06_10315	COG0210	DNA helicase
HUT06_10320	COG2226	methyltransferase
HUT06_10330	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_10345	COG0019	diaminopimelate decarboxylase activity
HUT06_10350	COG4264	IucA IucC family
HUT06_10360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT06_10375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT06_10395	COG1946	Acyl-CoA thioesterase
HUT06_10400	COG2197	response regulator
HUT06_10405	COG4585	Histidine kinase
HUT06_10410	COG0596	Alpha beta hydrolase
HUT06_10430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT06_10455	COG1418	mRNA catabolic process
HUT06_10485	COG1615	UPF0182 protein
HUT06_10500	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT06_10510	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_10520	COG0506	proline dehydrogenase activity
HUT06_10525	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_10555	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_10560	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_10570	COG0300	oxidoreductase activity
HUT06_10580	COG1309	transcriptional regulator
HUT06_10590	COG0579	oxidoreductase
HUT06_10600	COG0483	inositol monophosphate 1-phosphatase activity
HUT06_10620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT06_10640	COG2135	peptidase activity
HUT06_10650	COG2226	methyltransferase
HUT06_10655	COG1595	DNA-templated transcription, initiation
HUT06_10660	COG5662	AntiSigma factor
HUT06_10665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT06_10670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUT06_10670	COG2199	diguanylate cyclase activity
HUT06_10735	COG3629	intracellular signal transduction
HUT06_10735	COG3903	Transcriptional regulator
HUT06_10740	COG0277	FAD linked oxidase domain protein
HUT06_10745	COG2205	protein histidine kinase activity
HUT06_10750	COG0745	RESPONSE REGULATOR receiver
HUT06_10770	COG1136	(ABC) transporter
HUT06_10770	COG0577	efflux transmembrane transporter activity
HUT06_10830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_10910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT06_10915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT06_10940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT06_10945	COG0439	Biotin carboxylase
HUT06_10970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUT06_10975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUT06_10985	COG2188	Transcriptional regulator
HUT06_11005	COG1597	lipid kinase activity
HUT06_11020	COG2172	sigma factor antagonist activity
HUT06_11040	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_11055	COG2186	Transcriptional regulator
HUT06_11065	COG1175	transmembrane transport
HUT06_11070	COG3833	ABC-type maltose transport systems, permease component
HUT06_11080	COG4948	Mandelate Racemase Muconate Lactonizing
HUT06_11100	COG1131	(ABC) transporter
HUT06_11115	COG4585	Histidine kinase
HUT06_11120	COG2197	response regulator
HUT06_11160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT06_11165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT06_11170	COG0281	malic enzyme
HUT06_11175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_11180	COG0765	amino acid transport
HUT06_11185	COG1126	abc transporter atp-binding protein
HUT06_11215	COG0604	alcohol dehydrogenase
HUT06_11235	COG0567	Dehydrogenase, E1 component
HUT06_11235	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT06_11245	COG0435	Glutathione S-transferase
HUT06_11250	COG0586	Pfam SNARE associated Golgi protein
HUT06_11260	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_11265	COG1024	Enoyl-CoA hydratase
HUT06_11280	COG2018	Roadblock/LC7 domain
HUT06_11300	COG2018	Roadblock/LC7 domain
HUT06_11315	COG1940	carbohydrate kinase activity
HUT06_11315	COG1846	Transcriptional regulator
HUT06_11320	COG1129	ABC transporter
HUT06_11325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_11330	COG4213	ABC transporter substrate-binding protein
HUT06_11335	COG0673	inositol 2-dehydrogenase activity
HUT06_11405	COG2226	methyltransferase
HUT06_11410	COG0438	transferase activity, transferring glycosyl groups
HUT06_11415	COG2124	cytochrome p450
HUT06_11420	COG2124	cytochrome p450
HUT06_11425	COG0488	(ABC) transporter
HUT06_11440	COG0183	Belongs to the thiolase family
HUT06_11445	COG2124	cytochrome p450
HUT06_11460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT06_11465	COG0463	Glycosyl transferase, family 2
HUT06_11470	COG2124	cytochrome p450
HUT06_11475	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_11495	COG3835	regulator
HUT06_11505	COG2351	hydroxyisourate hydrolase activity
HUT06_11530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT06_11535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT06_11540	COG4266	Belongs to the allantoicase family
HUT06_11555	COG1309	transcriptional regulator
HUT06_11560	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_11565	COG1960	acyl-CoA dehydrogenase activity
HUT06_11570	COG1960	acyl-CoA dehydrogenase activity
HUT06_11575	COG0076	glutamate decarboxylase activity
HUT06_11580	COG1309	transcriptional regulator
HUT06_11585	COG0477	Major facilitator Superfamily
HUT06_11600	COG3572	ergothioneine biosynthetic process
HUT06_11605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT06_11615	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUT06_11640	COG1609	Transcriptional regulator
HUT06_11645	COG2986	histidine ammonia-lyase
HUT06_11650	COG0517	IMP dehydrogenase activity
HUT06_11650	COG1125	glycine betaine transport
HUT06_11655	COG1174	glycine betaine transport
HUT06_11660	COG1174	glycine betaine transport
HUT06_11690	COG0596	Alpha beta hydrolase
HUT06_11715	COG2814	Major facilitator Superfamily
HUT06_11740	COG2986	histidine ammonia-lyase
HUT06_11745	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUT06_11755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT06_11795	COG1228	amidohydrolase
HUT06_11805	COG0616	signal peptide processing
HUT06_11825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUT06_11835	COG2186	Transcriptional regulator
HUT06_11850	COG0366	Alpha amylase catalytic
HUT06_11855	COG0058	SHG alpha-glucan phosphorylase activity
HUT06_11865	COG1476	TRANSCRIPTIONal
HUT06_11880	COG4585	Histidine kinase
HUT06_11885	COG4279	zinc finger
HUT06_11890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT06_11900	COG1733	regulation of RNA biosynthetic process
HUT06_11910	COG4221	oxidoreductase activity
HUT06_11940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUT06_11975	COG0482	sulfurtransferase activity
HUT06_11990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT06_12010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT06_12015	COG0154	amidase activity
HUT06_12020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT06_12025	COG2133	pyrroloquinoline quinone binding
HUT06_12030	COG5001	Diguanylate cyclase
HUT06_12045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT06_12060	COG1136	(ABC) transporter
HUT06_12060	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUT06_12090	COG0473	3-isopropylmalate dehydrogenase activity
HUT06_12095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT06_12100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT06_12145	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_12180	COG2409	Drug exporters of the RND superfamily
HUT06_12195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_12205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT06_12215	COG0713	ATP synthesis coupled electron transport
HUT06_12230	COG1007	ATP synthesis coupled electron transport
HUT06_12240	COG1126	abc transporter atp-binding protein
HUT06_12245	COG0765	amino acid transport
HUT06_12255	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HUT06_12260	COG0583	DNA-binding transcription factor activity
HUT06_12265	COG2084	Dehydrogenase
HUT06_12275	COG0789	Transcriptional regulator
HUT06_12280	COG1414	Transcriptional regulator
HUT06_12285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT06_12290	COG0066	3-isopropylmalate dehydratase activity
HUT06_12300	COG0776	regulation of translation
HUT06_12310	COG1920	GTP binding
HUT06_12320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT06_12325	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT06_12370	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_12395	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_12435	COG0351	phosphomethylpyrimidine kinase
HUT06_12440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT06_12445	COG1461	Dihydroxyacetone kinase
HUT06_12470	COG0742	ribosomal rna small subunit methyltransferase
HUT06_12480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUT06_12490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUT06_12495	COG0571	ribonuclease III activity
HUT06_12500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT06_12505	COG1254	Belongs to the acylphosphatase family
HUT06_12515	COG1196	nuclear chromosome segregation
HUT06_12525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT06_12550	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT06_12560	COG0228	four-way junction DNA binding
HUT06_12565	COG1837	Belongs to the UPF0109 family
HUT06_12570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUT06_12585	COG0336	Belongs to the RNA methyltransferase TrmD family
HUT06_12590	COG0335	large ribosomal subunit rRNA binding
HUT06_12595	COG0681	Belongs to the peptidase S26 family
HUT06_12600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT06_12620	COG0792	nuclease activity
HUT06_12625	COG4974	Belongs to the 'phage' integrase family
HUT06_12635	COG0052	Belongs to the universal ribosomal protein uS2 family
HUT06_12640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUT06_12645	COG0528	UMP kinase activity
HUT06_12650	COG0233	cytoplasmic translational termination
HUT06_12655	COG0575	Belongs to the CDS family
HUT06_12665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUT06_12705	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_12710	COG3842	ATPase activity
HUT06_12720	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT06_12725	COG1177	transmembrane transport
HUT06_12745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_12770	COG0515	serine threonine protein kinase
HUT06_12785	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT06_12795	COG0596	Alpha beta hydrolase
HUT06_12805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT06_12845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT06_12850	COG0596	Alpha beta hydrolase
HUT06_12855	COG0596	Alpha beta hydrolase
HUT06_12890	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HUT06_12915	COG0477	Major facilitator Superfamily
HUT06_12925	COG0633	Ferredoxin
HUT06_12925	COG0543	2 iron, 2 sulfur cluster binding
HUT06_12930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT06_12945	COG2205	protein histidine kinase activity
HUT06_12955	COG2318	DinB family
HUT06_12965	COG0537	adenosine 5'-monophosphoramidase activity
HUT06_13005	COG1515	deoxyribonuclease V activity
HUT06_13015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUT06_13015	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUT06_13030	COG1309	transcriptional regulator
HUT06_13080	COG4213	ABC transporter substrate-binding protein
HUT06_13090	COG4214	carbohydrate transport
HUT06_13100	COG1940	carbohydrate kinase activity
HUT06_13140	COG0779	Required for maturation of 30S ribosomal subunits
HUT06_13155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUT06_13165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUT06_13170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUT06_13175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUT06_13190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUT06_13195	COG1185	polyribonucleotide nucleotidyltransferase activity
HUT06_13200	COG0612	Peptidase, M16
HUT06_13205	COG1950	PFAM Membrane protein of
HUT06_13210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT06_13215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT06_13225	COG0456	acetyltransferase
HUT06_13240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT06_13255	COG0477	Major facilitator Superfamily
HUT06_13280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT06_13305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT06_13310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT06_13315	COG1674	ftsk spoiiie
HUT06_13325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT06_13340	COG1058	Belongs to the CinA family
HUT06_13340	COG1546	Belongs to the CinA family
HUT06_13345	COG1396	sequence-specific DNA binding
HUT06_13360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT06_13375	COG0395	ABC-type sugar transport system, permease component
HUT06_13380	COG1175	transmembrane transport
HUT06_13395	COG0653	protein targeting
HUT06_13400	COG1201	RNA secondary structure unwinding
HUT06_13420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUT06_13425	COG2137	regulation of response to DNA damage stimulus
HUT06_13430	COG1418	mRNA catabolic process
HUT06_13435	COG1073	alpha beta
HUT06_13440	COG0765	amino acid transport
HUT06_13445	COG0765	amino acid transport
HUT06_13450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_13455	COG1126	abc transporter atp-binding protein
HUT06_13460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT06_13475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUT06_13480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUT06_13515	COG0247	lactate metabolic process
HUT06_13520	COG0277	FAD linked oxidase domain protein
HUT06_13525	COG0277	FAD linked oxidase domain protein
HUT06_13535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUT06_13540	COG1228	amidohydrolase
HUT06_13545	COG1307	EDD domain protein, DegV family
HUT06_13580	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUT06_13585	COG0268	Binds directly to 16S ribosomal RNA
HUT06_13590	COG0481	GTPase activity
HUT06_13625	COG1420	regulation of RNA biosynthetic process
HUT06_13630	COG0484	heat shock protein binding
HUT06_13650	COG0537	adenosine 5'-monophosphoramidase activity
HUT06_13660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT06_13675	COG2409	Drug exporters of the RND superfamily
HUT06_13680	COG3903	Transcriptional regulator
HUT06_13680	COG3629	intracellular signal transduction
HUT06_13685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUT06_13700	COG1834	amidinotransferase
HUT06_13705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT06_13720	COG1381	Involved in DNA repair and RecF pathway recombination
HUT06_13725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT06_13730	COG1764	response to oxidative stress
HUT06_13745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT06_13750	COG1121	(ABC) transporter
HUT06_13755	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT06_13775	COG0423	glycine-tRNA ligase activity
HUT06_13790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT06_13790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT06_13805	COG3387	PFAM Glycoside hydrolase 15-related
HUT06_13810	COG0574	Belongs to the PEP-utilizing enzyme family
HUT06_13810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT06_13820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT06_13825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT06_13830	COG2223	nitrite transmembrane transporter activity
HUT06_13840	COG1595	DNA-templated transcription, initiation
HUT06_13845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_13850	COG0789	Transcriptional regulator
HUT06_13875	COG0358	DNA primase activity
HUT06_13880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT06_13885	COG0393	Putative heavy-metal-binding
HUT06_13895	COG2837	iron assimilation
HUT06_13935	COG1358	cellular component organization or biogenesis
HUT06_13985	COG0270	DNA (cytosine-5-)-methyltransferase activity
HUT06_14055	COG2188	Transcriptional regulator
HUT06_14065	COG0305	Participates in initiation and elongation during chromosome replication
HUT06_14080	COG3629	intracellular signal transduction
HUT06_14100	COG2111	Na H antiporter
HUT06_14100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT06_14125	COG1320	monovalent cation:proton antiporter activity
HUT06_14135	COG4585	Histidine kinase
HUT06_14140	COG2197	response regulator
HUT06_14165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_14170	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_14175	COG1120	ATPase activity
HUT06_14200	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUT06_14250	COG0477	Major facilitator Superfamily
HUT06_14270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT06_14290	COG0531	amino acid
HUT06_14295	COG0405	Gamma-glutamyltransferase
HUT06_14310	COG0477	Major facilitator Superfamily
HUT06_14320	COG1937	Protein conserved in bacteria
HUT06_14325	COG0588	phosphoglycerate mutase activity
HUT06_14340	COG1929	Belongs to the glycerate kinase type-1 family
HUT06_14345	COG2252	PERMEase
HUT06_14350	COG3835	regulator
HUT06_14370	COG3336	cytochrome c oxidase
HUT06_14375	COG4585	Histidine kinase
HUT06_14380	COG2197	response regulator
HUT06_14400	COG0745	RESPONSE REGULATOR receiver
HUT06_14405	COG2205	protein histidine kinase activity
HUT06_14450	COG0475	glutathione-regulated potassium exporter activity
HUT06_14450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT06_14465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT06_14470	COG0477	Major facilitator Superfamily
HUT06_14495	COG1674	ftsk spoiiie
HUT06_14555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT06_14555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUT06_14575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_14580	COG0765	amino acid transport
HUT06_14585	COG1126	abc transporter atp-binding protein
HUT06_14590	COG0174	glutamine synthetase
HUT06_14595	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUT06_14610	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT06_14620	COG2267	carboxylic ester hydrolase activity
HUT06_14660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUT06_14670	COG0321	lipoyl(octanoyl) transferase activity
HUT06_14675	COG3340	Belongs to the peptidase S51 family
HUT06_14680	COG1090	epimerase
HUT06_14690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT06_14695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT06_14700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUT06_14720	COG0667	Aldo Keto reductase
HUT06_14740	COG0501	Belongs to the peptidase M48B family
HUT06_14750	COG0501	Belongs to the peptidase M48B family
HUT06_14760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUT06_14770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT06_14780	COG1104	cysteine desulfurase activity
HUT06_14785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUT06_14790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT06_14800	COG1376	ErfK ybiS ycfS ynhG family protein
HUT06_14805	COG0501	Belongs to the peptidase M48B family
HUT06_14820	COG0791	NLP P60 protein
HUT06_14845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT06_14855	COG1845	cytochrome c oxidase, subunit III
HUT06_14860	COG2010	Cytochrome c
HUT06_14865	COG0723	plastoquinol--plastocyanin reductase activity
HUT06_14870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT06_14875	COG0438	transferase activity, transferring glycosyl groups
HUT06_14920	COG1022	Amp-dependent synthetase and ligase
HUT06_14925	COG3142	Participates in the control of copper homeostasis
HUT06_14940	COG1940	carbohydrate kinase activity
HUT06_14965	COG2197	response regulator
HUT06_14975	COG3220	belongs to the UPF0276 family
HUT06_14980	COG3220	belongs to the UPF0276 family
HUT06_14990	COG0301	tRNA thio-modification
HUT06_15000	COG0697	spore germination
HUT06_15005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUT06_15010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT06_15015	COG3275	phosphorelay sensor kinase activity
HUT06_15030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT06_15035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT06_15040	COG0515	serine threonine protein kinase
HUT06_15040	COG2815	serine threonine protein kinase
HUT06_15045	COG0697	spore germination
HUT06_15050	COG2022	thiamine diphosphate biosynthetic process
HUT06_15060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT06_15060	COG2022	thiamine diphosphate biosynthetic process
HUT06_15075	COG0352	thiamine-phosphate diphosphorylase activity
HUT06_15090	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT06_15145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_15175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUT06_15180	COG0540	Belongs to the ATCase OTCase family
HUT06_15185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT06_15190	COG0505	Belongs to the CarA family
HUT06_15200	COG0543	2 iron, 2 sulfur cluster binding
HUT06_15205	COG0167	dihydroorotate dehydrogenase activity
HUT06_15210	COG0284	orotidine-5'-phosphate decarboxylase activity
HUT06_15220	COG0194	GDP metabolic process
HUT06_15225	COG1758	RNA polymerase activity
HUT06_15235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT06_15245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUT06_15255	COG0242	peptide deformylase activity
HUT06_15260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUT06_15270	COG0671	phosphoesterase, PA-phosphatase related
HUT06_15275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUT06_15280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT06_15355	COG3201	nicotinamide mononucleotide transporter
HUT06_15360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT06_15360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT06_15365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUT06_15370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUT06_15410	COG3608	succinylglutamate desuccinylase aspartoacylase
HUT06_15410	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUT06_15415	COG0746	molybdenum cofactor guanylyltransferase activity
HUT06_15440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUT06_15445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUT06_15455	COG2508	Transcriptional regulator
HUT06_15460	COG2233	PERMEase
HUT06_15515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT06_15520	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HUT06_15540	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_15545	COG1309	transcriptional regulator
HUT06_15555	COG1131	(ABC) transporter
HUT06_15565	COG4585	Histidine kinase
HUT06_15570	COG2197	response regulator
HUT06_15610	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_15660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT06_15665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT06_15670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT06_15675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUT06_15680	COG1309	transcriptional regulator
HUT06_15690	COG1024	Enoyl-CoA hydratase
HUT06_15695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_15705	COG0006	proline dipeptidase activity
HUT06_15710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUT06_15715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUT06_15725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT06_15745	COG0714	Associated with various cellular activities
HUT06_15750	COG2001	Belongs to the MraZ family
HUT06_15755	COG0275	rRNA processing
HUT06_15765	COG0768	penicillin binding
HUT06_15770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT06_15775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUT06_15780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT06_15785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT06_15795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUT06_15800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUT06_15810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUT06_15825	COG1799	cell septum assembly
HUT06_15835	COG3599	regulation of cell shape
HUT06_15850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUT06_15860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUT06_15885	COG0587	DNA-directed DNA polymerase activity
HUT06_15910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUT06_15915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT06_15920	COG0384	phenazine biosynthesis protein PhzF
HUT06_15925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUT06_15930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT06_15935	COG0131	Imidazoleglycerol-phosphate dehydratase
HUT06_15945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUT06_15950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUT06_15955	COG0107	imidazoleglycerol-phosphate synthase activity
HUT06_15965	COG1960	acyl-CoA dehydrogenase activity
HUT06_15970	COG1960	acyl-CoA dehydrogenase activity
HUT06_16005	COG1132	(ABC) transporter
HUT06_16010	COG1132	(ABC) transporter
HUT06_16020	COG1278	Cold shock
HUT06_16025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT06_16035	COG0745	RESPONSE REGULATOR receiver
HUT06_16045	COG0134	indole-3-glycerol-phosphate synthase activity
HUT06_16050	COG0133	tryptophan synthase activity
HUT06_16055	COG0159	tryptophan synthase activity
HUT06_16075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUT06_16095	COG0067	glutamate synthase
HUT06_16095	COG0070	glutamate synthase
HUT06_16095	COG0069	glutamate synthase activity
HUT06_16130	COG0693	protein deglycase activity
HUT06_16180	COG2050	protein possibly involved in aromatic compounds catabolism
HUT06_16210	COG0237	dephospho-CoA kinase activity
HUT06_16230	COG5635	Nacht domain
HUT06_16230	COG2319	Wd-40 repeat
HUT06_16255	COG4585	Histidine kinase
HUT06_16260	COG0556	nucleotide-excision repair
HUT06_16295	COG2197	response regulator
HUT06_16300	COG4585	Histidine kinase
HUT06_16340	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_16360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT06_16380	COG2070	2-Nitropropane dioxygenase
HUT06_16395	COG1126	abc transporter atp-binding protein
HUT06_16400	COG0765	amino acid transport
HUT06_16405	COG0765	amino acid transport
HUT06_16415	COG5285	phytanoyl-CoA dioxygenase
HUT06_16420	COG1917	Cupin 2, conserved barrel domain protein
HUT06_16425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT06_16430	COG0456	acetyltransferase
HUT06_16445	COG0504	CTP synthase activity
HUT06_16470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUT06_16475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUT06_16485	COG4401	Chorismate mutase type I
HUT06_16495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUT06_16500	COG1160	GTP binding
HUT06_16540	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUT06_16565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUT06_16580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT06_16590	COG0542	response to heat
HUT06_16610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT06_16685	COG0248	Ppx GppA phosphatase
HUT06_16690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT06_16695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT06_16705	COG0477	Major facilitator Superfamily
HUT06_16720	COG1357	PFAM Pentapeptide repeats (8 copies)
HUT06_16725	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT06_16750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT06_16755	COG0583	DNA-binding transcription factor activity
HUT06_16765	COG2205	protein histidine kinase activity
HUT06_16770	COG0745	RESPONSE REGULATOR receiver
HUT06_16790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT06_16815	COG0586	Pfam SNARE associated Golgi protein
HUT06_16820	COG4585	Histidine kinase
HUT06_16825	COG2201	protein-glutamate methylesterase activity
HUT06_16830	COG1063	alcohol dehydrogenase
HUT06_16875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT06_16895	COG0477	Major facilitator Superfamily
HUT06_16955	COG1595	DNA-templated transcription, initiation
HUT06_16965	COG1960	acyl-CoA dehydrogenase activity
HUT06_16980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT06_17000	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_17015	COG1120	ATPase activity
HUT06_17020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_17030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_17050	COG0477	Major facilitator Superfamily
HUT06_17095	COG0776	regulation of translation
HUT06_17100	COG0427	acetyl-CoA hydrolase
HUT06_17135	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_17175	COG0010	Belongs to the arginase family
HUT06_17180	COG0477	Major facilitator Superfamily
HUT06_17200	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_17240	COG1024	Enoyl-CoA hydratase
HUT06_17250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT06_17270	COG0745	RESPONSE REGULATOR receiver
HUT06_17280	COG1937	Protein conserved in bacteria
HUT06_17290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT06_17295	COG0730	response to heat
HUT06_17315	COG1177	transmembrane transport
HUT06_17320	COG3842	ATPase activity
HUT06_17340	COG1960	acyl-CoA dehydrogenase activity
HUT06_17350	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_17380	COG0798	PFAM Bile acid sodium symporter
HUT06_17385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT06_17395	COG2072	flavoprotein involved in K transport
HUT06_17400	COG0640	Transcriptional regulator
HUT06_17430	COG2208	phosphoserine phosphatase activity
HUT06_17455	COG0596	Alpha beta hydrolase
HUT06_17485	COG1960	acyl-CoA dehydrogenase activity
HUT06_17495	COG1141	Ferredoxin
HUT06_17510	COG0300	oxidoreductase activity
HUT06_17510	COG3321	synthase
HUT06_17510	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_17510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT06_17510	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_17525	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT06_17535	COG2124	cytochrome p450
HUT06_17540	COG0475	glutathione-regulated potassium exporter activity
HUT06_17555	COG3903	Transcriptional regulator
HUT06_17555	COG3629	intracellular signal transduction
HUT06_17565	COG2124	cytochrome p450
HUT06_17575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT06_17580	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_17600	COG2197	response regulator
HUT06_17610	COG1131	(ABC) transporter
HUT06_17635	COG4257	antibiotic catabolic process
HUT06_17640	COG0110	maltose O-acetyltransferase activity
HUT06_17645	COG0583	DNA-binding transcription factor activity
HUT06_17665	COG0596	Alpha beta hydrolase
HUT06_17705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_17710	COG1414	Transcriptional regulator
HUT06_17720	COG0477	Major facilitator Superfamily
HUT06_17725	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_17735	COG0583	DNA-binding transcription factor activity
HUT06_17815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT06_17820	COG0438	transferase activity, transferring glycosyl groups
HUT06_17825	COG1960	acyl-CoA dehydrogenase activity
HUT06_17830	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_17835	COG1309	transcriptional regulator
HUT06_17840	COG0183	Belongs to the thiolase family
HUT06_17845	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HUT06_17850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT06_17855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT06_17865	COG1414	Transcriptional regulator
HUT06_17870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT06_17880	COG1802	Transcriptional regulator
HUT06_17885	COG1024	Enoyl-CoA hydratase
HUT06_17890	COG1960	acyl-CoA dehydrogenase activity
HUT06_17900	COG0667	Aldo Keto reductase
HUT06_17925	COG1024	Enoyl-CoA hydratase
HUT06_17930	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_17935	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_17940	COG0515	serine threonine protein kinase
HUT06_17945	COG1643	Atp-dependent helicase
HUT06_17980	COG1119	ATPase activity
HUT06_18030	COG2050	protein possibly involved in aromatic compounds catabolism
HUT06_18055	COG1131	(ABC) transporter
HUT06_18060	COG4585	Histidine kinase
HUT06_18065	COG2197	response regulator
HUT06_18200	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_18215	COG1129	ABC transporter
HUT06_18220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_18235	COG1960	acyl-CoA dehydrogenase activity
HUT06_18260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT06_18280	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_18285	COG0494	nUDIX hydrolase
HUT06_18300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUT06_18310	COG2205	protein histidine kinase activity
HUT06_18310	COG3437	response regulator, receiver
HUT06_18310	COG3850	Histidine kinase
HUT06_18310	COG4999	Histidine kinase
HUT06_18330	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT06_18340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT06_18410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT06_18415	COG2124	cytochrome p450
HUT06_18425	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_18430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_18435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT06_18445	COG2124	cytochrome p450
HUT06_18485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT06_18490	COG4166	transmembrane transport
HUT06_18495	COG0601	transmembrane transport
HUT06_18500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT06_18505	COG0444	Belongs to the ABC transporter superfamily
HUT06_18510	COG4608	Belongs to the ABC transporter superfamily
HUT06_18520	COG0702	epimerase
HUT06_18550	COG2172	sigma factor antagonist activity
HUT06_18555	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT06_18560	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT06_18585	COG2366	antibiotic biosynthetic process
HUT06_18595	COG0488	(ABC) transporter
HUT06_18625	COG0789	Transcriptional regulator
HUT06_18635	COG1733	regulation of RNA biosynthetic process
HUT06_18650	COG2271	Major facilitator Superfamily
HUT06_18715	COG0583	DNA-binding transcription factor activity
HUT06_18720	COG1132	(ABC) transporter
HUT06_18745	COG3971	2-oxopent-4-enoate hydratase activity
HUT06_18760	COG1917	Cupin 2, conserved barrel domain protein
HUT06_18770	COG3844	kynureninase activity
HUT06_18775	COG1278	Cold shock
HUT06_18780	COG0738	Major facilitator superfamily
HUT06_18810	COG2197	response regulator
HUT06_18815	COG4585	Histidine kinase
HUT06_18820	COG2226	methyltransferase
HUT06_18825	COG0477	Major facilitator Superfamily
HUT06_18830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT06_18870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUT06_18875	COG1560	Kdo2-lipid A biosynthetic process
HUT06_18880	COG0438	transferase activity, transferring glycosyl groups
HUT06_18895	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUT06_18905	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUT06_18910	COG0217	transcriptional regulatory protein
HUT06_18915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUT06_18920	COG0632	four-way junction helicase activity
HUT06_18925	COG2255	four-way junction helicase activity
HUT06_18930	COG1862	Preprotein translocase
HUT06_18935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT06_18940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT06_18945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT06_18950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT06_18955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUT06_18960	COG0124	histidyl-tRNA synthetase
HUT06_18970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUT06_18975	COG1196	nuclear chromosome segregation
HUT06_19015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT06_19020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUT06_19030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUT06_19065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUT06_19070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT06_19080	COG5002	protein histidine kinase activity
HUT06_19085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUT06_19090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT06_19090	COG0072	phenylalanine-tRNA ligase activity
HUT06_19105	COG4555	ABC transporter
HUT06_19110	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT06_19110	COG1672	PFAM Archaeal ATPase
HUT06_19115	COG0488	(ABC) transporter
HUT06_19140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUT06_19145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUT06_19150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT06_19155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT06_19160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT06_19165	COG1438	arginine binding
HUT06_19170	COG0137	argininosuccinate synthase activity
HUT06_19175	COG0165	Argininosuccinate lyase
HUT06_19180	COG2094	Belongs to the DNA glycosylase MPG family
HUT06_19185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUT06_19225	COG1309	transcriptional regulator
HUT06_19235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT06_19265	COG1316	TRANSCRIPTIONal
HUT06_19275	COG1522	sequence-specific DNA binding
HUT06_19290	COG0477	Major facilitator Superfamily
HUT06_19325	COG0436	Aminotransferase
HUT06_19340	COG1376	ErfK ybiS ycfS ynhG family protein
HUT06_19345	COG1376	ErfK ybiS ycfS ynhG family protein
HUT06_19365	COG2205	protein histidine kinase activity
HUT06_19370	COG0745	RESPONSE REGULATOR receiver
HUT06_19385	COG1136	(ABC) transporter
HUT06_19385	COG0577	efflux transmembrane transporter activity
HUT06_19390	COG0577	efflux transmembrane transporter activity
HUT06_19395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_19405	COG1070	Carbohydrate kinase
HUT06_19440	COG0395	ABC-type sugar transport system, permease component
HUT06_19450	COG5297	Belongs to the glycosyl hydrolase family 6
HUT06_19465	COG4733	cellulase activity
HUT06_19465	COG5297	Belongs to the glycosyl hydrolase family 6
HUT06_19470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT06_19490	COG2197	response regulator
HUT06_19565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_19570	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_19575	COG1120	ATPase activity
HUT06_19585	COG0477	Major facilitator Superfamily
HUT06_19590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT06_19595	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT06_19645	COG1169	isochorismate synthase
HUT06_19660	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT06_19675	COG2814	Major facilitator Superfamily
HUT06_19695	COG1309	transcriptional regulator
HUT06_19725	COG1349	DNA-binding transcription factor activity
HUT06_19730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT06_19735	COG1063	alcohol dehydrogenase
HUT06_19740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT06_19740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT06_19745	COG2213	PTS system mannitol-specific
HUT06_19755	COG1105	Belongs to the carbohydrate kinase PfkB family
HUT06_19765	COG0697	spore germination
HUT06_19800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT06_19815	COG1960	acyl-CoA dehydrogenase activity
HUT06_19855	COG0673	inositol 2-dehydrogenase activity
HUT06_19885	COG2076	Multidrug Resistance protein
HUT06_19900	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_19930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT06_19940	COG3290	protein histidine kinase activity
HUT06_19945	COG4565	transcriptional regulatory protein
HUT06_19950	COG4555	ABC transporter
HUT06_19980	COG1215	transferase activity, transferring glycosyl groups
HUT06_19985	COG1960	acyl-CoA dehydrogenase activity
HUT06_19990	COG1309	transcriptional regulator
HUT06_20025	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_20035	COG2378	regulation of single-species biofilm formation
HUT06_20040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT06_20060	COG2050	protein possibly involved in aromatic compounds catabolism
HUT06_20075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUT06_20105	COG1690	Belongs to the RtcB family
HUT06_20115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUT06_20125	COG0300	oxidoreductase activity
HUT06_20130	COG3973	AAA domain
HUT06_20145	COG1960	acyl-CoA dehydrogenase activity
HUT06_20150	COG1960	acyl-CoA dehydrogenase activity
HUT06_20155	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUT06_20160	COG0563	adenylate kinase activity
HUT06_20170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUT06_20170	COG3608	succinylglutamate desuccinylase aspartoacylase
HUT06_20185	COG3485	protocatechuate 3,4-dioxygenase
HUT06_20190	COG3485	protocatechuate 3,4-dioxygenase
HUT06_20195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT06_20205	COG1414	Transcriptional regulator
HUT06_20215	COG2409	Drug exporters of the RND superfamily
HUT06_20225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT06_20225	COG0189	ligase activity
HUT06_20240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT06_20255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HUT06_20270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT06_20290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT06_20295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT06_20320	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_20325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT06_20325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT06_20330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT06_20335	COG0297	glycogen (starch) synthase activity
HUT06_20345	COG0859	PFAM glycosyl transferase family 9
HUT06_20350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUT06_20355	COG2192	nodulation
HUT06_20370	COG0477	Major facilitator Superfamily
HUT06_20385	COG1881	PFAM PEBP family protein
HUT06_20390	COG0667	Aldo Keto reductase
HUT06_20395	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_20400	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_20400	COG2030	dehydratase
HUT06_20405	COG0583	DNA-binding transcription factor activity
HUT06_20410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT06_20420	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_20425	COG0022	dehydrogenase e1 component
HUT06_20490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT06_20505	COG2188	Transcriptional regulator
HUT06_20525	COG0702	epimerase
HUT06_20550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUT06_20555	COG4585	Histidine kinase
HUT06_20565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT06_20570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT06_20575	COG1280	lysine exporter protein (LysE YggA)
HUT06_20620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT06_20620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT06_20645	COG0247	lactate metabolic process
HUT06_20650	COG1139	Iron-sulfur cluster binding protein
HUT06_20655	COG1556	Lactate utilization protein
HUT06_20675	COG2223	nitrite transmembrane transporter activity
HUT06_20690	COG0243	molybdopterin cofactor binding
HUT06_20730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT06_20750	COG4948	Mandelate Racemase Muconate Lactonizing
HUT06_20755	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUT06_20780	COG0475	glutathione-regulated potassium exporter activity
HUT06_20790	COG1169	isochorismate synthase
HUT06_20840	COG1733	regulation of RNA biosynthetic process
HUT06_20845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUT06_20860	COG1649	PFAM Uncharacterised BCR, COG1649
HUT06_20930	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT06_20950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT06_20955	COG1295	ribonuclease BN
HUT06_20980	COG0477	Major facilitator Superfamily
HUT06_20985	COG2197	response regulator
HUT06_20990	COG4585	Histidine kinase
HUT06_20995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT06_21015	COG2608	mercury ion transmembrane transporter activity
HUT06_21030	COG3634	alkyl hydroperoxide reductase activity
HUT06_21035	COG2814	Major facilitator Superfamily
HUT06_21070	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUT06_21080	COG4608	Belongs to the ABC transporter superfamily
HUT06_21120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT06_21150	COG4974	Belongs to the 'phage' integrase family
HUT06_21210	COG1715	Restriction endonuclease
HUT06_21330	COG0419	ATPase involved in DNA repair
HUT06_21340	COG0477	Major facilitator Superfamily
HUT06_21400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT06_21460	COG3547	Transposase (IS116 IS110 IS902 family)
HUT06_21595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT06_21635	COG1595	DNA-templated transcription, initiation
HUT06_21655	COG4977	sequence-specific DNA binding
HUT06_21710	COG1846	Transcriptional regulator
HUT06_21715	COG2378	regulation of single-species biofilm formation
HUT06_21730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT06_21730	COG2111	Na H antiporter
HUT06_21765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_21810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT06_21820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUT06_21825	COG1132	(ABC) transporter
HUT06_21835	COG4988	ABC transporter
HUT06_21845	COG1271	oxidase subunit
HUT06_21920	COG2197	response regulator
HUT06_21930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT06_21950	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT06_21960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT06_21975	COG3795	YCII-related domain
HUT06_21990	COG1739	Uncharacterized protein family UPF0029
HUT06_22035	COG0583	DNA-binding transcription factor activity
HUT06_22055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT06_22085	COG0583	DNA-binding transcription factor activity
HUT06_22100	COG3467	pyridoxamine 5'-phosphate
HUT06_22120	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_22130	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT06_22135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUT06_22135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUT06_22140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUT06_22150	COG2205	protein histidine kinase activity
HUT06_22155	COG0745	RESPONSE REGULATOR receiver
HUT06_22165	COG1162	GTPase activity
HUT06_22185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT06_22215	COG0714	Associated with various cellular activities
HUT06_22225	COG2304	oxidoreductase activity
HUT06_22230	COG2813	Specifically methylates the guanine in position
HUT06_22235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT06_22240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUT06_22255	COG2813	Specifically methylates the guanine in position
HUT06_22285	COG0740	serine-type endopeptidase activity
HUT06_22290	COG0740	serine-type endopeptidase activity
HUT06_22300	COG2197	response regulator
HUT06_22315	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUT06_22320	COG1216	Glycosyl transferase, family 2
HUT06_22330	COG1607	acyl-coa hydrolase
HUT06_22335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT06_22340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUT06_22370	COG0604	alcohol dehydrogenase
HUT06_22375	COG1509	lysine 2,3-aminomutase activity
HUT06_22380	COG2124	cytochrome p450
HUT06_22390	COG1960	acyl-CoA dehydrogenase activity
HUT06_22400	COG1940	carbohydrate kinase activity
HUT06_22410	COG1175	transmembrane transport
HUT06_22415	COG0395	ABC-type sugar transport system, permease component
HUT06_22420	COG1486	melibiose metabolic process
HUT06_22435	COG1522	sequence-specific DNA binding
HUT06_22440	COG1609	Transcriptional regulator
HUT06_22450	COG0395	ABC-type sugar transport system, permease component
HUT06_22455	COG1175	transmembrane transport
HUT06_22460	COG1653	transport
HUT06_22475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT06_22490	COG5398	heme oxygenase
HUT06_22515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT06_22520	COG2146	nitrite reductase [NAD(P)H] activity
HUT06_22520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT06_22540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT06_22555	COG0247	lactate metabolic process
HUT06_22555	COG0277	FAD linked oxidase domain protein
HUT06_22560	COG3387	PFAM Glycoside hydrolase 15-related
HUT06_22570	COG0577	efflux transmembrane transporter activity
HUT06_22570	COG1136	(ABC) transporter
HUT06_22585	COG1131	(ABC) transporter
HUT06_22600	COG0805	protein transport
HUT06_22605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT06_22645	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT06_22650	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT06_22655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT06_22675	COG4122	O-methyltransferase activity
HUT06_22680	COG1222	aaa ATPase
HUT06_22690	COG0517	IMP dehydrogenase activity
HUT06_22690	COG1994	Peptidase M50
HUT06_22700	COG4585	Histidine kinase
HUT06_22705	COG2197	response regulator
HUT06_22710	COG1136	(ABC) transporter
HUT06_22710	COG0577	efflux transmembrane transporter activity
HUT06_22715	COG0577	efflux transmembrane transporter activity
HUT06_22715	COG1136	(ABC) transporter
HUT06_22725	COG0444	Belongs to the ABC transporter superfamily
HUT06_22735	COG0747	negative chemotaxis
HUT06_22740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT06_22750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT06_22765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUT06_22775	COG0215	cysteine-tRNA ligase activity
HUT06_22785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT06_22815	COG0598	Magnesium transport protein CorA
HUT06_22825	COG0667	Aldo Keto reductase
HUT06_22830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUT06_22845	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_22860	COG3360	Dodecin
HUT06_22895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT06_22895	COG1703	isobutyryl-CoA mutase activity
HUT06_22895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT06_22915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_22920	COG0477	Major facilitator Superfamily
HUT06_22940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT06_22945	COG2267	carboxylic ester hydrolase activity
HUT06_22955	COG1690	Belongs to the RtcB family
HUT06_22980	COG0709	Synthesizes selenophosphate from selenide and ATP
HUT06_23005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUT06_23025	COG0516	GMP reductase activity
HUT06_23025	COG0517	IMP dehydrogenase activity
HUT06_23030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT06_23035	COG2364	Membrane
HUT06_23040	COG1929	Belongs to the glycerate kinase type-1 family
HUT06_23050	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT06_23055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT06_23065	COG1132	(ABC) transporter
HUT06_23070	COG2936	dipeptidyl-peptidase activity
HUT06_23085	COG0488	(ABC) transporter
HUT06_23120	COG2197	response regulator
HUT06_23125	COG4585	Histidine kinase
HUT06_23135	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT06_23140	COG0822	iron-sulfur transferase activity
HUT06_23150	COG0396	ATPase activity
HUT06_23160	COG0719	Fe-S assembly protein
HUT06_23180	COG0531	amino acid
HUT06_23185	COG0549	Belongs to the carbamate kinase family
HUT06_23190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT06_23200	COG1131	(ABC) transporter
HUT06_23215	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT06_23220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT06_23220	COG1796	DNA polymerase
HUT06_23225	COG1612	heme a metabolic process
HUT06_23235	COG0109	protoheme IX farnesyltransferase activity
HUT06_23245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT06_23255	COG0166	Belongs to the GPI family
HUT06_23260	COG0166	Belongs to the GPI family
HUT06_23275	COG0363	glucosamine-6-phosphate deaminase activity
HUT06_23280	COG1376	ErfK ybiS ycfS ynhG family protein
HUT06_23300	COG4585	Histidine kinase
HUT06_23310	COG2197	response regulator
HUT06_23330	COG1695	Transcriptional regulator
HUT06_23340	COG4585	Histidine kinase
HUT06_23345	COG2197	response regulator
HUT06_23355	COG2409	Drug exporters of the RND superfamily
HUT06_23370	COG0574	Belongs to the PEP-utilizing enzyme family
HUT06_23370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT06_23400	COG0445	tRNA wobble uridine modification
HUT06_23410	COG2755	lipolytic protein G-D-S-L family
HUT06_23440	COG1309	transcriptional regulator
HUT06_23475	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_23495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT06_23540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_23545	COG2301	Belongs to the HpcH HpaI aldolase family
HUT06_23555	COG2079	MmgE PrpD family protein
HUT06_23590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT06_23600	COG1522	sequence-specific DNA binding
HUT06_23610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT06_23615	COG0149	triose-phosphate isomerase activity
HUT06_23620	COG0126	phosphoglycerate kinase activity
HUT06_23625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT06_23645	COG1481	regulation of sporulation
HUT06_23650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT06_23655	COG1660	Displays ATPase and GTPase activities
HUT06_23660	COG0322	excinuclease ABC activity
HUT06_23675	COG2146	nitrite reductase [NAD(P)H] activity
HUT06_23680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT06_23685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT06_23700	COG3629	intracellular signal transduction
HUT06_23700	COG3903	Transcriptional regulator
HUT06_23710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT06_23770	COG1960	acyl-CoA dehydrogenase activity
HUT06_23805	COG0497	DNA recombination
HUT06_23810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT06_23830	COG0647	UMP catabolic process
HUT06_23890	COG1024	Enoyl-CoA hydratase
HUT06_23910	COG0673	inositol 2-dehydrogenase activity
HUT06_23940	COG1140	nitrate reductase beta subunit
HUT06_23980	COG0076	glutamate decarboxylase activity
HUT06_23985	COG0247	lactate metabolic process
HUT06_23985	COG0277	FAD linked oxidase domain protein
HUT06_23990	COG1414	Transcriptional regulator
HUT06_23995	COG3971	2-oxopent-4-enoate hydratase activity
HUT06_24035	COG0513	Belongs to the DEAD box helicase family
HUT06_24040	COG1278	Cold shock
HUT06_24070	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_24080	COG1309	transcriptional regulator
HUT06_24125	COG0024	Methionine aminopeptidase
HUT06_24160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT06_24165	COG1278	Cold shock
HUT06_24215	COG0439	Biotin carboxylase
HUT06_24235	COG4948	Mandelate Racemase Muconate Lactonizing
HUT06_24255	COG1175	transmembrane transport
HUT06_24260	COG0395	ABC-type sugar transport system, permease component
HUT06_24270	COG0673	inositol 2-dehydrogenase activity
HUT06_24290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT06_24295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT06_24300	COG0829	nickel cation binding
HUT06_24305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUT06_24310	COG0830	nickel cation binding
HUT06_24325	COG0831	urea catabolic process
HUT06_24330	COG4413	Urea transporter
HUT06_24340	COG0531	amino acid
HUT06_24345	COG2301	Belongs to the HpcH HpaI aldolase family
HUT06_24350	COG1960	acyl-CoA dehydrogenase activity
HUT06_24370	COG2030	dehydratase
HUT06_24385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_24390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_24395	COG2030	dehydratase
HUT06_24410	COG2188	Transcriptional regulator
HUT06_24415	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_24435	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUT06_24480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT06_24485	COG0747	negative chemotaxis
HUT06_24490	COG0444	Belongs to the ABC transporter superfamily
HUT06_24495	COG4608	Belongs to the ABC transporter superfamily
HUT06_24510	COG1414	Transcriptional regulator
HUT06_24530	COG0431	NADPH-dependent FMN reductase
HUT06_24530	COG1053	succinate dehydrogenase
HUT06_24530	COG3976	FMN-binding domain protein
HUT06_24580	COG1414	Transcriptional regulator
HUT06_24600	COG1846	Transcriptional regulator
HUT06_24630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUT06_24635	COG1309	transcriptional regulator
HUT06_24665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT06_24670	COG0531	amino acid
HUT06_24675	COG1349	DNA-binding transcription factor activity
HUT06_24680	COG1309	transcriptional regulator
HUT06_24685	COG2130	NADP-dependent
HUT06_24690	COG1902	pentaerythritol trinitrate reductase activity
HUT06_24690	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT06_24700	COG4585	Histidine kinase
HUT06_24705	COG2197	response regulator
HUT06_24715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT06_24725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUT06_24730	COG1024	Enoyl-CoA hydratase
HUT06_24735	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HUT06_24775	COG1131	(ABC) transporter
HUT06_24825	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_24830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT06_24835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT06_24840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_24850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_24855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT06_24865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT06_24870	COG1228	amidohydrolase
HUT06_24875	COG1819	glycosyl
HUT06_24895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT06_24915	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_24920	COG0251	oxidation-reduction process
HUT06_24945	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HUT06_24960	COG2770	Histidine kinase
HUT06_24960	COG2208	phosphoserine phosphatase activity
HUT06_24970	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT06_24980	COG3618	amidohydrolase
HUT06_25020	COG4213	ABC transporter substrate-binding protein
HUT06_25025	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_25030	COG1129	ABC transporter
HUT06_25045	COG1024	Enoyl-CoA hydratase
HUT06_25065	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT06_25105	COG0640	Transcriptional regulator
HUT06_25115	COG2814	Major facilitator Superfamily
HUT06_25130	COG2130	NADP-dependent
HUT06_25135	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT06_25150	COG2365	Tyrosine phosphatase family
HUT06_25205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT06_25210	COG1595	DNA-templated transcription, initiation
HUT06_25230	COG1902	pentaerythritol trinitrate reductase activity
HUT06_25230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT06_25235	COG2267	carboxylic ester hydrolase activity
HUT06_25240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUT06_25250	COG1129	ABC transporter
HUT06_25255	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_25260	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_25265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT06_25275	COG1414	Transcriptional regulator
HUT06_25285	COG0800	Aldolase
HUT06_25295	COG0251	oxidation-reduction process
HUT06_25305	COG0477	Major facilitator Superfamily
HUT06_25325	COG0596	Alpha beta hydrolase
HUT06_25330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HUT06_25335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUT06_25340	COG2197	response regulator
HUT06_25345	COG4585	Histidine kinase
HUT06_25355	COG1136	(ABC) transporter
HUT06_25385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUT06_25390	COG0659	secondary active sulfate transmembrane transporter activity
HUT06_25395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT06_25400	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT06_25405	COG3842	ATPase activity
HUT06_25455	COG1335	isochorismatase
HUT06_25485	COG0436	Aminotransferase
HUT06_25490	COG1802	Transcriptional regulator
HUT06_25625	COG0416	fatty acid biosynthetic process
HUT06_25635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUT06_25645	COG1233	COG1233 Phytoene dehydrogenase and related
HUT06_25685	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HUT06_25700	COG0726	polysaccharide deacetylase
HUT06_25720	COG1131	(ABC) transporter
HUT06_25740	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT06_25750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT06_25760	COG2205	protein histidine kinase activity
HUT06_25765	COG0745	RESPONSE REGULATOR receiver
HUT06_25770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT06_25770	COG1017	nitric oxide dioxygenase activity
HUT06_25820	COG1233	COG1233 Phytoene dehydrogenase and related
HUT06_25830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUT06_25830	COG3620	sequence-specific DNA binding
HUT06_25830	COG0617	tRNA 3'-terminal CCA addition
HUT06_25870	COG0589	response to stress
HUT06_25875	COG0531	amino acid
HUT06_25885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT06_25890	COG0549	Belongs to the carbamate kinase family
HUT06_25970	COG0589	response to stress
HUT06_26040	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_26045	COG1024	Enoyl-CoA hydratase
HUT06_26050	COG2267	carboxylic ester hydrolase activity
HUT06_26060	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_26065	COG1024	Enoyl-CoA hydratase
HUT06_26085	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_26100	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUT06_26105	COG0683	leucine binding
HUT06_26190	COG3328	transposase activity
HUT06_26235	COG0383	alpha-mannosidase activity
HUT06_26240	COG0613	PHP domain protein
HUT06_26245	COG3842	ATPase activity
HUT06_26250	COG0395	ABC-type sugar transport system, permease component
HUT06_26260	COG2182	Extracellular solute-binding protein
HUT06_26270	COG0640	Transcriptional regulator
HUT06_26320	COG1105	Belongs to the carbohydrate kinase PfkB family
HUT06_26360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_26365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT06_26415	COG1960	acyl-CoA dehydrogenase activity
HUT06_26445	COG0437	4 iron, 4 sulfur cluster binding
HUT06_26470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT06_26480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT06_26520	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_26530	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT06_26545	COG1609	Transcriptional regulator
HUT06_26555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT06_26570	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HUT06_26585	COG0431	NADPH-dependent FMN reductase
HUT06_26590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_26595	COG0789	Transcriptional regulator
HUT06_26605	COG2353	YceI-like domain
HUT06_26650	COG0596	Alpha beta hydrolase
HUT06_26655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT06_26660	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_26665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT06_26670	COG3321	synthase
HUT06_26670	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_26670	COG0604	alcohol dehydrogenase
HUT06_26685	COG3509	depolymerase
HUT06_26700	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HUT06_26705	COG1797	cobyrinic acid a,c-diamide synthase activity
HUT06_26750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT06_26755	COG1968	undecaprenyl-diphosphatase activity
HUT06_26770	COG0402	S-adenosylhomocysteine deaminase activity
HUT06_26775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_26795	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_26795	COG3321	synthase
HUT06_26795	COG0604	alcohol dehydrogenase
HUT06_26800	COG1414	Transcriptional regulator
HUT06_26840	COG2072	flavoprotein involved in K transport
HUT06_26855	COG1940	carbohydrate kinase activity
HUT06_26855	COG1846	Transcriptional regulator
HUT06_26860	COG1126	abc transporter atp-binding protein
HUT06_26865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT06_26870	COG0765	amino acid transport
HUT06_26875	COG0765	amino acid transport
HUT06_26885	COG3142	Participates in the control of copper homeostasis
HUT06_26890	COG0366	Alpha amylase catalytic
HUT06_26905	COG0366	Alpha amylase catalytic
HUT06_26910	COG3281	Trehalose synthase
HUT06_26925	COG1116	anion transmembrane transporter activity
HUT06_26930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT06_26935	COG1077	Cell shape determining protein MreB Mrl
HUT06_26950	COG2814	Major facilitator Superfamily
HUT06_26955	COG4715	Zinc finger, swim domain protein
HUT06_26960	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUT06_26965	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HUT06_26970	COG0714	Associated with various cellular activities
HUT06_26975	COG3831	ATPase activity
HUT06_26995	COG0596	Alpha beta hydrolase
HUT06_27005	COG0626	cystathionine gamma-synthase activity
HUT06_27015	COG3831	ATPase activity
HUT06_27020	COG3831	ATPase activity
HUT06_27025	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT06_27035	COG0174	glutamine synthetase
HUT06_27080	COG1309	transcriptional regulator
HUT06_27085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT06_27090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUT06_27100	COG0235	Class ii aldolase
HUT06_27100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUT06_27110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT06_27115	COG0587	DNA-directed DNA polymerase activity
HUT06_27125	COG0248	Ppx GppA phosphatase
HUT06_27135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT06_27145	COG2814	Major facilitator Superfamily
HUT06_27155	COG0656	L-ascorbic acid biosynthetic process
HUT06_27170	COG3250	beta-galactosidase activity
HUT06_27175	COG3250	beta-galactosidase activity
HUT06_27200	COG3347	Dehydrogenase
HUT06_27200	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_27210	COG3254	rhamnose metabolic process
HUT06_27215	COG1879	ABC-type sugar transport system periplasmic component
HUT06_27220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_27230	COG1129	ABC transporter
HUT06_27240	COG0247	lactate metabolic process
HUT06_27245	COG1139	Iron-sulfur cluster binding protein
HUT06_27250	COG1556	Lactate utilization protein
HUT06_27255	COG1070	Carbohydrate kinase
HUT06_27260	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT06_27260	COG1672	PFAM Archaeal ATPase
HUT06_27280	COG3467	pyridoxamine 5'-phosphate
HUT06_27320	COG1643	Atp-dependent helicase
HUT06_27345	COG3284	Transcriptional regulator
HUT06_27365	COG0183	Belongs to the thiolase family
HUT06_27395	COG2755	lipolytic protein G-D-S-L family
HUT06_27400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUT06_27410	COG3695	enzyme binding
HUT06_27440	COG2340	Cysteine-rich secretory protein family
HUT06_27455	COG0604	alcohol dehydrogenase
HUT06_27455	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_27455	COG3321	synthase
HUT06_27490	COG1063	alcohol dehydrogenase
HUT06_27510	COG1401	restriction endodeoxyribonuclease activity
HUT06_27520	COG1733	regulation of RNA biosynthetic process
HUT06_27580	COG0210	DNA helicase
HUT06_27585	COG0515	serine threonine protein kinase
HUT06_27595	COG0328	RNA-DNA hybrid ribonuclease activity
HUT06_27630	COG2409	Drug exporters of the RND superfamily
HUT06_27635	COG2197	response regulator
HUT06_27640	COG4585	Histidine kinase
HUT06_27665	COG0477	Major facilitator Superfamily
HUT06_27705	COG0668	transmembrane transport
HUT06_27725	COG0438	transferase activity, transferring glycosyl groups
HUT06_27730	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT06_27730	COG1672	PFAM Archaeal ATPase
HUT06_27750	COG0515	serine threonine protein kinase
HUT06_27760	COG1132	(ABC) transporter
HUT06_27770	COG2197	response regulator
HUT06_27785	COG1070	Carbohydrate kinase
HUT06_27790	COG1349	DNA-binding transcription factor activity
HUT06_27805	COG3250	beta-galactosidase activity
HUT06_27815	COG1175	transmembrane transport
HUT06_27820	COG0395	ABC-type sugar transport system, permease component
HUT06_27850	COG3251	PFAM MbtH domain protein
HUT06_27855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT06_27860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT06_27875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT06_27890	COG0604	alcohol dehydrogenase
HUT06_27900	COG1960	acyl-CoA dehydrogenase activity
HUT06_27930	COG0235	Class ii aldolase
HUT06_27940	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_27955	COG0443	Heat shock 70 kDa protein
HUT06_27980	COG0778	Nitroreductase
HUT06_27985	COG1309	transcriptional regulator
HUT06_27995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT06_28025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT06_28035	COG3473	Maleate cis-trans isomerase
HUT06_28045	COG2186	Transcriptional regulator
HUT06_28055	COG1960	acyl-CoA dehydrogenase activity
HUT06_28065	COG1309	transcriptional regulator
HUT06_28080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_28100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT06_28125	COG0714	Associated with various cellular activities
HUT06_28145	COG0714	Associated with various cellular activities
HUT06_28150	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HUT06_28155	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUT06_28165	COG0515	serine threonine protein kinase
HUT06_28165	COG2815	serine threonine protein kinase
HUT06_28175	COG0640	Transcriptional regulator
HUT06_28190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUT06_28210	COG1597	lipid kinase activity
HUT06_28220	COG0667	Aldo Keto reductase
HUT06_28275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT06_28295	COG2132	Multicopper oxidase
HUT06_28315	COG0419	ATPase involved in DNA repair
HUT06_28320	COG0420	3'-5' exonuclease activity
HUT06_28325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT06_28325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT06_28330	COG0590	tRNA wobble adenosine to inosine editing
HUT06_28395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT06_28405	COG3718	enzyme involved in inositol metabolism
HUT06_28420	COG0673	inositol 2-dehydrogenase activity
HUT06_28435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT06_28470	COG0456	acetyltransferase
HUT06_28495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT06_28510	COG0386	Belongs to the glutathione peroxidase family
HUT06_28530	COG1316	TRANSCRIPTIONal
HUT06_28535	COG1132	(ABC) transporter
HUT06_28540	COG0464	growth
HUT06_28565	COG2018	Roadblock/LC7 domain
HUT06_28570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUT06_28585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT06_28600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT06_28605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT06_28610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUT06_28610	COG1116	anion transmembrane transporter activity
HUT06_28705	COG0175	sulfate reduction
HUT06_28725	COG1960	acyl-CoA dehydrogenase activity
HUT06_28745	COG2197	response regulator
HUT06_28750	COG4585	Histidine kinase
HUT06_28845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUT06_28855	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT06_28870	COG0702	epimerase
HUT06_28880	COG0789	Transcriptional regulator
HUT06_28885	COG1309	transcriptional regulator
HUT06_28890	COG0477	Major facilitator Superfamily
HUT06_28900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT06_28910	COG1349	DNA-binding transcription factor activity
HUT06_28935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT06_28945	COG1793	dna ligase
HUT06_28950	COG3540	Alkaline phosphatase
HUT06_28960	COG2186	Transcriptional regulator
HUT06_28965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT06_28975	COG2936	dipeptidyl-peptidase activity
HUT06_28990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT06_29025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUT06_29045	COG0672	)-iron permease
HUT06_29055	COG0577	efflux transmembrane transporter activity
HUT06_29060	COG1136	(ABC) transporter
HUT06_29060	COG0577	efflux transmembrane transporter activity
HUT06_29080	COG0745	RESPONSE REGULATOR receiver
HUT06_29085	COG2205	protein histidine kinase activity
HUT06_29090	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_29160	COG3559	Exporter of polyketide antibiotics
HUT06_29165	COG1131	(ABC) transporter
HUT06_29170	COG2267	carboxylic ester hydrolase activity
HUT06_29190	COG2124	cytochrome p450
HUT06_29225	COG3433	isochorismatase activity
HUT06_29225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT06_29225	COG2226	methyltransferase
HUT06_29240	COG2226	methyltransferase
HUT06_29240	COG3433	isochorismatase activity
HUT06_29240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT06_29260	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HUT06_29275	COG0604	alcohol dehydrogenase
HUT06_29275	COG3321	synthase
HUT06_29275	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_29285	COG0475	glutathione-regulated potassium exporter activity
HUT06_29290	COG0644	oxidoreductase
HUT06_29295	COG3903	Transcriptional regulator
HUT06_29295	COG3629	intracellular signal transduction
HUT06_29300	COG0825	malonyl-CoA metabolic process
HUT06_29300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUT06_29305	COG0511	ligase activity, forming carbon-carbon bonds
HUT06_29310	COG0439	Biotin carboxylase
HUT06_29320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_29345	COG3629	intracellular signal transduction
HUT06_29355	COG0183	Belongs to the thiolase family
HUT06_29360	COG1024	Enoyl-CoA hydratase
HUT06_29360	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT06_29365	COG0531	amino acid
HUT06_29385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT06_29390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT06_29405	COG0395	ABC-type sugar transport system, permease component
HUT06_29430	COG0667	Aldo Keto reductase
HUT06_29435	COG1280	lysine exporter protein (LysE YggA)
HUT06_29440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUT06_29455	COG2272	Belongs to the type-B carboxylesterase lipase family
HUT06_29475	COG1562	ergosterol biosynthetic process
HUT06_29485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT06_29495	COG1657	PFAM Prenyltransferase squalene oxidase
HUT06_29535	COG0800	Aldolase
HUT06_29540	COG0837	glucose binding
HUT06_29565	COG0484	heat shock protein binding
HUT06_29575	COG0484	heat shock protein binding
HUT06_29585	COG0484	heat shock protein binding
HUT06_29635	COG0657	acetylesterase activity
HUT06_29660	COG0438	transferase activity, transferring glycosyl groups
HUT06_29680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT06_29680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT06_29685	COG3541	Predicted nucleotidyltransferase
HUT06_29695	COG1653	transport
HUT06_29710	COG0366	Alpha amylase catalytic
HUT06_29715	COG1609	Transcriptional regulator
HUT06_29730	COG0395	ABC-type sugar transport system, permease component
HUT06_29735	COG2723	6-phospho-beta-galactosidase activity
HUT06_29780	COG2814	Major facilitator Superfamily
HUT06_29790	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT06_29795	COG0395	ABC-type sugar transport system, permease component
HUT06_29800	COG1175	transmembrane transport
HUT06_29815	COG4336	lyase activity
HUT06_29820	COG1984	allophanate hydrolase subunit 2
HUT06_29825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUT06_29830	COG1914	H( )-stimulated, divalent metal cation uptake system
HUT06_29835	COG2188	Transcriptional regulator
HUT06_29840	COG1802	Transcriptional regulator
HUT06_29845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT06_29850	COG0022	dehydrogenase e1 component
HUT06_29855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT06_29875	COG1595	DNA-templated transcription, initiation
HUT06_29905	COG1940	carbohydrate kinase activity
HUT06_29905	COG1846	Transcriptional regulator
HUT06_29910	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT06_29920	COG4106	trans-aconitate 2-methyltransferase activity
HUT06_29930	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT06_29970	COG1482	cell wall glycoprotein biosynthetic process
HUT06_29980	COG1522	sequence-specific DNA binding
HUT06_29985	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_30000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT06_30005	COG2226	methyltransferase
HUT06_30020	COG0477	Major facilitator Superfamily
HUT06_30040	COG4552	Acetyltransferase involved in intracellular survival and related
HUT06_30045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT06_30050	COG0531	amino acid
HUT06_30055	COG0569	domain protein
HUT06_30080	COG1136	(ABC) transporter
HUT06_30105	COG0756	dUTP diphosphatase activity
HUT06_30145	COG0706	membrane insertase activity
HUT06_30155	COG0525	valine-tRNA ligase activity
HUT06_30180	COG2205	protein histidine kinase activity
HUT06_30185	COG0745	RESPONSE REGULATOR receiver
HUT06_30195	COG0483	inositol monophosphate 1-phosphatase activity
HUT06_30205	COG0739	heme binding
HUT06_30230	COG3402	PFAM membrane-flanked domain
HUT06_30250	COG1252	NADH dehydrogenase
HUT06_30255	COG1881	PFAM PEBP family protein
HUT06_30265	COG0659	secondary active sulfate transmembrane transporter activity
HUT06_30290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT06_30295	COG4608	Belongs to the ABC transporter superfamily
HUT06_30300	COG0444	Belongs to the ABC transporter superfamily
HUT06_30310	COG0747	negative chemotaxis
HUT06_30315	COG2186	Transcriptional regulator
HUT06_30335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUT06_30465	COG0517	IMP dehydrogenase activity
HUT06_30475	COG0464	growth
HUT06_30480	COG4451	ribulose bisphosphate carboxylase, small
HUT06_30485	COG1850	ribulose-bisphosphate carboxylase activity
HUT06_30490	COG0583	DNA-binding transcription factor activity
HUT06_30500	COG3268	Saccharopine dehydrogenase
HUT06_30510	COG2197	response regulator
HUT06_30515	COG0572	uridine kinase
HUT06_30540	COG0432	Pfam Uncharacterised protein family UPF0047
HUT06_30550	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT06_30575	COG0477	Major facilitator Superfamily
HUT06_30580	COG1846	Transcriptional regulator
HUT06_30590	COG3385	transposase activity
HUT06_30605	COG0667	Aldo Keto reductase
HUT06_30610	COG1309	transcriptional regulator
HUT06_30615	COG2378	regulation of single-species biofilm formation
HUT06_30630	COG2267	carboxylic ester hydrolase activity
HUT06_30635	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_30660	COG0410	ABC transporter
HUT06_30695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT06_30695	COG1796	DNA polymerase
HUT06_30700	COG4585	Histidine kinase
HUT06_30705	COG2197	response regulator
HUT06_30735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT06_30740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT06_30820	COG2267	carboxylic ester hydrolase activity
HUT06_30830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT06_30835	COG1309	transcriptional regulator
HUT06_30890	COG1464	Belongs to the NlpA lipoprotein family
HUT06_30895	COG2011	ABC-type metal ion transport system permease component
HUT06_30900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT06_30930	COG1309	transcriptional regulator
HUT06_30935	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_30950	COG4585	Histidine kinase
HUT06_30955	COG1131	(ABC) transporter
HUT06_30970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT06_31040	COG2197	response regulator
HUT06_31050	COG0187	DNA topoisomerase II activity
HUT06_31055	COG1131	(ABC) transporter
HUT06_31075	COG3022	response to hydroperoxide
HUT06_31080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT06_31085	COG4191	Histidine kinase
HUT06_31095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT06_31140	COG1984	allophanate hydrolase subunit 2
HUT06_31160	COG0596	Alpha beta hydrolase
HUT06_31165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT06_31175	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUT06_31175	COG0778	Nitroreductase
HUT06_31230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUT06_31235	COG0495	leucyl-tRNA aminoacylation
HUT06_31240	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_31250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT06_31255	COG0596	Alpha beta hydrolase
HUT06_31270	COG0667	Aldo Keto reductase
HUT06_31275	COG1793	dna ligase
HUT06_31295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT06_31300	COG0277	FAD linked oxidase domain protein
HUT06_31330	COG0436	Aminotransferase
HUT06_31335	COG0577	efflux transmembrane transporter activity
HUT06_31340	COG1136	(ABC) transporter
HUT06_31370	COG1683	Conserved Protein
HUT06_31460	COG0406	alpha-ribazole phosphatase activity
HUT06_31470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUT06_31475	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HUT06_31485	COG0501	Belongs to the peptidase M48B family
HUT06_31495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT06_31500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUT06_31505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT06_31510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUT06_31515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUT06_31520	COG1530	ribonuclease E activity
HUT06_31535	COG0772	Belongs to the SEDS family
HUT06_31555	COG1077	Cell shape determining protein MreB Mrl
HUT06_31560	COG0105	UTP biosynthetic process
HUT06_31575	COG0285	dihydrofolate synthase activity
HUT06_31590	COG0525	valine-tRNA ligase activity
HUT06_31605	COG2197	response regulator
HUT06_31610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT06_31615	COG0740	serine-type endopeptidase activity
HUT06_31620	COG0740	serine-type endopeptidase activity
HUT06_31625	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUT06_31635	COG2183	response to ionizing radiation
HUT06_31670	COG1309	transcriptional regulator
HUT06_31685	COG1733	regulation of RNA biosynthetic process
HUT06_31725	COG3467	pyridoxamine 5'-phosphate
HUT06_31730	COG2315	Protein conserved in bacteria
HUT06_31735	COG2315	Protein conserved in bacteria
HUT06_31755	COG1595	DNA-templated transcription, initiation
HUT06_31780	COG3540	Alkaline phosphatase
HUT06_31810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT06_31820	COG0596	Alpha beta hydrolase
HUT06_31830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_31840	COG3291	Pkd domain containing protein
HUT06_31845	COG4608	Belongs to the ABC transporter superfamily
HUT06_31855	COG0601	transmembrane transport
HUT06_31860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT06_31870	COG0006	proline dipeptidase activity
HUT06_31880	COG1802	Transcriptional regulator
HUT06_31895	COG1802	Transcriptional regulator
HUT06_31920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT06_31925	COG3938	Belongs to the proline racemase family
HUT06_31965	COG5398	heme oxygenase
HUT06_31970	COG1120	ATPase activity
HUT06_31975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_31980	COG4558	Periplasmic binding protein
HUT06_32010	COG1063	alcohol dehydrogenase
HUT06_32070	COG4213	ABC transporter substrate-binding protein
HUT06_32075	COG1129	ABC transporter
HUT06_32080	COG4214	carbohydrate transport
HUT06_32085	COG1609	Transcriptional regulator
HUT06_32110	COG2160	L-arabinose isomerase activity
HUT06_32115	COG0235	Class ii aldolase
HUT06_32120	COG1609	Transcriptional regulator
HUT06_32125	COG0477	Major facilitator Superfamily
HUT06_32130	COG1473	amidohydrolase
HUT06_32145	COG0243	molybdopterin cofactor binding
HUT06_32145	COG3383	formate dehydrogenase (NAD+) activity
HUT06_32150	COG3383	formate dehydrogenase (NAD+) activity
HUT06_32150	COG0243	molybdopterin cofactor binding
HUT06_32155	COG0709	Synthesizes selenophosphate from selenide and ATP
HUT06_32175	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_32220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_32235	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_32270	COG2409	Drug exporters of the RND superfamily
HUT06_32275	COG1595	DNA-templated transcription, initiation
HUT06_32285	COG0519	Catalyzes the synthesis of GMP from XMP
HUT06_32285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT06_32295	COG0154	amidase activity
HUT06_32300	COG5002	protein histidine kinase activity
HUT06_32305	COG2815	serine threonine protein kinase
HUT06_32305	COG0515	serine threonine protein kinase
HUT06_32320	COG0698	ribose 5-phosphate isomerase
HUT06_32335	COG1122	ATPase activity
HUT06_32350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT06_32370	COG0154	amidase activity
HUT06_32380	COG0129	dihydroxy-acid dehydratase activity
HUT06_32400	COG1505	serine-type exopeptidase activity
HUT06_32425	COG0668	transmembrane transport
HUT06_32435	COG0366	Alpha amylase catalytic
HUT06_32445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT06_32480	COG3706	GGDEF domain
HUT06_32485	COG0629	single-stranded DNA binding
HUT06_32500	COG1648	precorrin-2 dehydrogenase activity
HUT06_32500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT06_32505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT06_32530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT06_32555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_32560	COG0028	Belongs to the TPP enzyme family
HUT06_32575	COG4585	Histidine kinase
HUT06_32580	COG2197	response regulator
HUT06_32595	COG0587	DNA-directed DNA polymerase activity
HUT06_32610	COG1309	transcriptional regulator
HUT06_32655	COG1492	cobalamin metabolic process
HUT06_32670	COG3328	transposase activity
HUT06_32700	COG0515	serine threonine protein kinase
HUT06_32760	COG0583	DNA-binding transcription factor activity
HUT06_32770	COG1595	DNA-templated transcription, initiation
HUT06_32780	COG3485	protocatechuate 3,4-dioxygenase
HUT06_32795	COG4977	sequence-specific DNA binding
HUT06_32845	COG0740	serine-type endopeptidase activity
HUT06_32850	COG0740	serine-type endopeptidase activity
HUT06_32855	COG1396	sequence-specific DNA binding
HUT06_32860	COG2267	carboxylic ester hydrolase activity
HUT06_32870	COG4106	trans-aconitate 2-methyltransferase activity
HUT06_32890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT06_32895	COG4221	oxidoreductase activity
HUT06_32915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT06_32915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT06_32920	COG0785	Cytochrome C biogenesis protein
HUT06_32930	COG0601	transmembrane transport
HUT06_32935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT06_32940	COG1124	(ABC) transporter
HUT06_32945	COG1132	(ABC) transporter
HUT06_32950	COG1132	(ABC) transporter
HUT06_32955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT06_32960	COG1120	ATPase activity
HUT06_32965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_32970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_32995	COG1802	Transcriptional regulator
HUT06_33000	COG1960	acyl-CoA dehydrogenase activity
HUT06_33005	COG2234	aminopeptidase activity
HUT06_33030	COG0577	efflux transmembrane transporter activity
HUT06_33030	COG1136	(ABC) transporter
HUT06_33060	COG1053	succinate dehydrogenase
HUT06_33065	COG1120	ATPase activity
HUT06_33070	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_33075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT06_33135	COG0583	DNA-binding transcription factor activity
HUT06_33140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT06_33170	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HUT06_33170	COG3261	NADH dehydrogenase
HUT06_33175	COG0651	ATP synthesis coupled electron transport
HUT06_33185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT06_33195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_33220	COG3469	chitinase activity
HUT06_33400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT06_33400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT06_33425	COG3831	ATPase activity
HUT06_33470	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HUT06_33480	COG3629	intracellular signal transduction
HUT06_33480	COG3903	Transcriptional regulator
HUT06_33510	COG2197	response regulator
HUT06_33630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUT06_33705	COG1047	Peptidyl-prolyl cis-trans
HUT06_33710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT06_33785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT06_33795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUT06_33805	COG2197	response regulator
HUT06_33820	COG0596	Alpha beta hydrolase
HUT06_33840	COG0583	DNA-binding transcription factor activity
HUT06_33845	COG0438	transferase activity, transferring glycosyl groups
HUT06_33845	COG1216	Glycosyl transferase, family 2
HUT06_33870	COG1053	succinate dehydrogenase
HUT06_33895	COG0431	NADPH-dependent FMN reductase
HUT06_33910	COG1960	acyl-CoA dehydrogenase activity
HUT06_33920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT06_33925	COG0739	heme binding
HUT06_33925	COG0741	lytic transglycosylase activity
HUT06_33925	COG1196	nuclear chromosome segregation
HUT06_33935	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUT06_33950	COG3387	PFAM Glycoside hydrolase 15-related
HUT06_33955	COG1063	alcohol dehydrogenase
HUT06_33990	COG3903	Transcriptional regulator
HUT06_33990	COG3629	intracellular signal transduction
HUT06_34025	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT06_34055	COG0653	protein targeting
HUT06_34090	COG2010	Cytochrome c
HUT06_34090	COG4993	Dehydrogenase
HUT06_34095	COG5000	phosphorelay sensor kinase activity
HUT06_34095	COG3279	Response regulator of the LytR AlgR family
HUT06_34100	COG2272	Belongs to the type-B carboxylesterase lipase family
HUT06_34110	COG1960	acyl-CoA dehydrogenase activity
HUT06_34115	COG1960	acyl-CoA dehydrogenase activity
HUT06_34120	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_34125	COG2723	6-phospho-beta-galactosidase activity
HUT06_34150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT06_34185	COG1902	pentaerythritol trinitrate reductase activity
HUT06_34240	COG0183	Belongs to the thiolase family
HUT06_34250	COG1960	acyl-CoA dehydrogenase activity
HUT06_34260	COG1960	acyl-CoA dehydrogenase activity
HUT06_34265	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_34295	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_34315	COG2855	membrane
HUT06_34340	COG0156	8-amino-7-oxononanoate synthase activity
HUT06_34345	COG2409	Drug exporters of the RND superfamily
HUT06_34365	COG1595	DNA-templated transcription, initiation
HUT06_34370	COG3631	Ketosteroid isomerase-related protein
HUT06_34385	COG1960	acyl-CoA dehydrogenase activity
HUT06_34390	COG0183	Belongs to the thiolase family
HUT06_34410	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_34415	COG1309	transcriptional regulator
HUT06_34430	COG1960	acyl-CoA dehydrogenase activity
HUT06_34465	COG1309	transcriptional regulator
HUT06_34490	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_34505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT06_34515	COG4608	Belongs to the ABC transporter superfamily
HUT06_34580	COG3976	FMN-binding domain protein
HUT06_34580	COG1053	succinate dehydrogenase
HUT06_34590	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_34605	COG1053	succinate dehydrogenase
HUT06_34610	COG2267	carboxylic ester hydrolase activity
HUT06_34615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUT06_34625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_34665	COG1132	(ABC) transporter
HUT06_34680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUT06_34700	COG0675	Transposase, IS605 OrfB family
HUT06_34710	COG1584	GPR1 FUN34 yaaH family protein
HUT06_34725	COG1620	l-lactate permease
HUT06_34730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT06_34735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT06_34740	COG2080	2 iron, 2 sulfur cluster binding
HUT06_34805	COG1609	Transcriptional regulator
HUT06_34810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT06_34820	COG1116	anion transmembrane transporter activity
HUT06_34825	COG0673	inositol 2-dehydrogenase activity
HUT06_34860	COG0667	Aldo Keto reductase
HUT06_34895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUT06_34910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT06_34915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT06_34920	COG0477	Major facilitator Superfamily
HUT06_34960	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HUT06_34960	COG2508	Transcriptional regulator
HUT06_34970	COG1309	transcriptional regulator
HUT06_34975	COG0586	Pfam SNARE associated Golgi protein
HUT06_34990	COG3328	transposase activity
HUT06_35005	COG1834	amidinotransferase
HUT06_35035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT06_35045	COG0204	Acyl-transferase
HUT06_35065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT06_35070	COG1846	Transcriptional regulator
HUT06_35110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT06_35115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT06_35130	COG1309	transcriptional regulator
HUT06_35260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUT06_35285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT06_35295	COG1127	ABC transporter
HUT06_35305	COG1309	transcriptional regulator
HUT06_35320	COG1309	transcriptional regulator
HUT06_35350	COG1793	dna ligase
HUT06_35360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT06_35365	COG0750	zinc metalloprotease
HUT06_35375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT06_35380	COG0509	glycine decarboxylation via glycine cleavage system
HUT06_35385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT06_35390	COG1760	l-serine dehydratase
HUT06_35410	COG0789	Transcriptional regulator
HUT06_35430	COG0183	Belongs to the thiolase family
HUT06_35450	COG4565	transcriptional regulatory protein
HUT06_35455	COG3290	protein histidine kinase activity
HUT06_35485	COG2968	Membrane
HUT06_35490	COG1486	melibiose metabolic process
HUT06_35515	COG1606	tRNA processing
HUT06_35520	COG1691	(AIR) carboxylase
HUT06_35525	COG1691	(AIR) carboxylase
HUT06_35530	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HUT06_35570	COG4566	intracellular signal transduction
HUT06_35575	COG2197	response regulator
HUT06_35590	COG0204	Acyl-transferase
HUT06_35590	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_35615	COG1595	DNA-templated transcription, initiation
HUT06_35625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUT06_35630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUT06_35635	COG1234	tRNA 3'-trailer cleavage
HUT06_35640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUT06_35670	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUT06_35680	COG1335	isochorismatase
HUT06_35685	COG3265	gluconokinase activity
HUT06_35705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT06_35730	COG1678	Uncharacterized ACR, COG1678
HUT06_35750	COG1136	(ABC) transporter
HUT06_35760	COG2814	Major facilitator Superfamily
HUT06_35770	COG0183	Belongs to the thiolase family
HUT06_35785	COG0628	permease
HUT06_35805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT06_35830	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUT06_35845	COG1994	Peptidase M50
HUT06_35875	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_35895	COG1403	HNH endonuclease
HUT06_35945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUT06_35950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUT06_35955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUT06_35960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUT06_35965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT06_35970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUT06_35975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT06_35995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT06_36015	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT06_36020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUT06_36025	COG0254	rRNA binding
HUT06_36045	COG0083	homoserine kinase activity
HUT06_36050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT06_36055	COG0460	homoserine dehydrogenase
HUT06_36060	COG0019	diaminopimelate decarboxylase activity
HUT06_36065	COG0018	arginyl-trna synthetase
HUT06_36105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT06_36120	COG4585	Histidine kinase
HUT06_36145	COG0640	Transcriptional regulator
HUT06_36170	COG1657	PFAM Prenyltransferase squalene oxidase
HUT06_36180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT06_36200	COG3835	regulator
HUT06_36235	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT06_36245	COG2508	Transcriptional regulator
HUT06_36275	COG0395	ABC-type sugar transport system, permease component
HUT06_36295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT06_36315	COG0596	Alpha beta hydrolase
HUT06_36325	COG2124	cytochrome p450
HUT06_36330	COG2130	NADP-dependent
HUT06_36340	COG0640	Transcriptional regulator
HUT06_36365	COG1132	(ABC) transporter
HUT06_36380	COG1316	TRANSCRIPTIONal
HUT06_36400	COG2211	Major facilitator Superfamily
HUT06_36415	COG1280	lysine exporter protein (LysE YggA)
HUT06_36420	COG1309	transcriptional regulator
HUT06_36425	COG2124	cytochrome p450
HUT06_36450	COG1090	epimerase
HUT06_36465	COG2072	flavoprotein involved in K transport
HUT06_36575	COG2197	response regulator
HUT06_36585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUT06_36595	COG0438	transferase activity, transferring glycosyl groups
HUT06_36610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT06_36640	COG2124	cytochrome p450
HUT06_36645	COG4585	Histidine kinase
HUT06_36650	COG2197	response regulator
HUT06_36670	COG0515	serine threonine protein kinase
HUT06_36685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUT06_36685	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUT06_36720	COG0321	lipoyl(octanoyl) transferase activity
HUT06_36720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUT06_36775	COG1511	domain protein
HUT06_36795	COG1846	Transcriptional regulator
HUT06_36805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT06_36825	COG1024	Enoyl-CoA hydratase
HUT06_36840	COG2070	2-Nitropropane dioxygenase
HUT06_36855	COG4981	capsule polysaccharide biosynthetic process
HUT06_36860	COG0438	transferase activity, transferring glycosyl groups
HUT06_36865	COG1216	Glycosyl transferase, family 2
HUT06_36875	COG1960	acyl-CoA dehydrogenase activity
HUT06_36890	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_36905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT06_36950	COG2814	Major facilitator Superfamily
HUT06_36960	COG3629	intracellular signal transduction
HUT06_36960	COG3903	Transcriptional regulator
HUT06_36965	COG0641	radical SAM
HUT06_36980	COG1053	succinate dehydrogenase
HUT06_36980	COG3976	FMN-binding domain protein
HUT06_37000	COG4106	trans-aconitate 2-methyltransferase activity
HUT06_37005	COG4608	Belongs to the ABC transporter superfamily
HUT06_37010	COG0444	Belongs to the ABC transporter superfamily
HUT06_37025	COG0747	negative chemotaxis
HUT06_37045	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_37050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_37070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT06_37090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT06_37095	COG0793	Belongs to the peptidase S41A family
HUT06_37105	COG2884	Cell division ATP-binding protein ftsE
HUT06_37120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT06_37130	COG2902	Dehydrogenase
HUT06_37150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT06_37160	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_37170	COG1011	Hydrolase
HUT06_37175	COG1960	acyl-CoA dehydrogenase activity
HUT06_37180	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUT06_37185	COG1737	Transcriptional regulator
HUT06_37195	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT06_37205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT06_37210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT06_37225	COG1263	PTS System
HUT06_37225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUT06_37235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUT06_37240	COG2188	Transcriptional regulator
HUT06_37245	COG1263	PTS System
HUT06_37255	COG0653	protein targeting
HUT06_37265	COG3214	Protein conserved in bacteria
HUT06_37270	COG2197	response regulator
HUT06_37275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUT06_37280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUT06_37285	COG5401	PFAM Sporulation and spore germination
HUT06_37290	COG5002	protein histidine kinase activity
HUT06_37290	COG5000	phosphorelay sensor kinase activity
HUT06_37295	COG0745	RESPONSE REGULATOR receiver
HUT06_37315	COG0714	Associated with various cellular activities
HUT06_37340	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUT06_37360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT06_37365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT06_37380	COG2197	response regulator
HUT06_37385	COG4585	Histidine kinase
HUT06_37395	COG2222	sugar isomerase
HUT06_37405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT06_37440	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT06_37445	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUT06_37445	COG0778	Nitroreductase
HUT06_37450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT06_37460	COG0583	DNA-binding transcription factor activity
HUT06_37520	COG3385	transposase activity
HUT06_37530	COG0515	serine threonine protein kinase
HUT06_37530	COG2815	serine threonine protein kinase
HUT06_37545	COG2226	methyltransferase
HUT06_37555	COG3118	belongs to the thioredoxin family
HUT06_37560	COG0438	transferase activity, transferring glycosyl groups
HUT06_37580	COG1316	TRANSCRIPTIONal
HUT06_37585	COG3594	Acyltransferase
HUT06_37590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT06_37605	COG0438	transferase activity, transferring glycosyl groups
HUT06_37635	COG0438	transferase activity, transferring glycosyl groups
HUT06_37670	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_37675	COG3973	AAA domain
HUT06_37685	COG1215	transferase activity, transferring glycosyl groups
HUT06_37705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUT06_37735	COG1316	TRANSCRIPTIONal
HUT06_37755	COG0738	Major facilitator superfamily
HUT06_37760	COG1349	DNA-binding transcription factor activity
HUT06_37805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT06_37810	COG1832	CoA-binding protein
HUT06_37815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUT06_37830	COG2205	protein histidine kinase activity
HUT06_37835	COG0745	RESPONSE REGULATOR receiver
HUT06_37865	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT06_37875	COG1024	Enoyl-CoA hydratase
HUT06_37885	COG4941	Belongs to the sigma-70 factor family
HUT06_37890	COG3795	YCII-related domain
HUT06_37895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUT06_37900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT06_37910	COG1432	Conserved Protein
HUT06_37990	COG1674	ftsk spoiiie
HUT06_38060	COG4770	biotin carboxylase activity
HUT06_38075	COG4585	Histidine kinase
HUT06_38080	COG2197	response regulator
HUT06_38110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT06_38120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT06_38160	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT06_38165	COG1476	TRANSCRIPTIONal
HUT06_38180	COG2018	Roadblock/LC7 domain
HUT06_38260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT06_38260	COG1473	amidohydrolase
HUT06_38265	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT06_38275	COG1295	ribonuclease BN
HUT06_38285	COG0180	Tryptophanyl-tRNA synthetase
HUT06_38290	COG1253	flavin adenine dinucleotide binding
HUT06_38295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT06_38300	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUT06_38310	COG0326	Molecular chaperone. Has ATPase activity
HUT06_38370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT06_38375	COG2318	DinB family
HUT06_38380	COG0039	L-malate dehydrogenase activity
HUT06_38400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT06_38415	COG0138	bifunctional purine biosynthesis protein purh
HUT06_38440	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT06_38455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT06_38490	COG1461	Dihydroxyacetone kinase
HUT06_38495	COG2376	Dihydroxyacetone kinase
HUT06_38500	COG1957	nucleoside hydrolase
HUT06_38525	COG2197	response regulator
HUT06_38575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT06_38580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT06_38585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT06_38595	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HUT06_38610	COG1090	epimerase
HUT06_38615	COG0450	alkyl hydroperoxide reductase
HUT06_38620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT06_38625	COG0519	Catalyzes the synthesis of GMP from XMP
HUT06_38625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT06_38650	COG1012	belongs to the aldehyde dehydrogenase family
HUT06_38660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT06_38665	COG0516	GMP reductase activity
HUT06_38685	COG1595	DNA-templated transcription, initiation
HUT06_38690	COG0459	protein refolding
HUT06_38695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT06_38715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT06_38725	COG0456	acetyltransferase
HUT06_38725	COG1214	PFAM Peptidase M22, glycoprotease
HUT06_38735	COG0802	atpase or kinase
HUT06_38745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT06_38780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT06_38785	COG1072	(Pantothenic acid kinase))
HUT06_38795	COG3831	ATPase activity
HUT06_38805	COG4585	Histidine kinase
HUT06_38810	COG2197	response regulator
HUT06_38820	COG1131	(ABC) transporter
HUT06_38830	COG1131	(ABC) transporter
HUT06_38850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT06_38855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUT06_38860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUT06_38865	COG2340	Cysteine-rich secretory protein family
HUT06_38880	COG0101	tRNA pseudouridine synthase activity
HUT06_38885	COG0203	ribosomal protein L17
HUT06_38890	COG0202	RNA polymerase activity
HUT06_38895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT06_38900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUT06_38905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUT06_38910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT06_38915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUT06_38930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUT06_38945	COG0563	adenylate kinase activity
HUT06_38950	COG0201	protein transport
HUT06_38955	COG0200	Binds to the 23S rRNA
HUT06_38965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUT06_38970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUT06_38975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUT06_38980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUT06_38985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT06_38990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUT06_38995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUT06_39000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUT06_39005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUT06_39010	COG0255	Belongs to the universal ribosomal protein uL29 family
HUT06_39015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUT06_39020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUT06_39025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUT06_39030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUT06_39035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUT06_39040	COG0089	rRNA binding
HUT06_39045	COG0088	Forms part of the polypeptide exit tunnel
HUT06_39050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUT06_39055	COG0051	transcription antitermination factor activity, RNA binding
HUT06_39060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT06_39065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT06_39070	COG0049	tRNA binding
HUT06_39075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUT06_39090	COG0667	Aldo Keto reductase
HUT06_39145	COG1595	DNA-templated transcription, initiation
HUT06_39170	COG2197	response regulator
HUT06_39250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT06_39260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUT06_39265	COG0085	RNA polymerase activity
HUT06_39285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUT06_39310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT06_39315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT06_39325	COG0222	ribosome binding
HUT06_39330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUT06_39365	COG1309	transcriptional regulator
HUT06_39375	COG0081	regulation of translation
HUT06_39380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUT06_39390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT06_39400	COG0436	Aminotransferase
HUT06_39410	COG1595	DNA-templated transcription, initiation
HUT06_39420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT06_39430	COG1802	Transcriptional regulator
HUT06_39435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUT06_39445	COG2030	dehydratase
HUT06_39450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT06_39465	COG1960	acyl-CoA dehydrogenase activity
HUT06_39575	COG1674	ftsk spoiiie
HUT06_39600	COG1666	GTP binding
HUT06_39605	COG0501	Belongs to the peptidase M48B family
HUT06_39610	COG1007	ATP synthesis coupled electron transport
HUT06_39620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT06_39625	COG0713	ATP synthesis coupled electron transport
HUT06_39635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_39645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT06_39650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_39655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_39660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_39675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT06_39675	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT06_39680	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT06_39755	COG2124	cytochrome p450
HUT06_39790	COG0583	DNA-binding transcription factor activity
HUT06_39795	COG2814	Major facilitator Superfamily
HUT06_39815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT06_39830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_39835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT06_39840	COG1034	ATP synthesis coupled electron transport
HUT06_39855	COG0649	NAD binding
HUT06_39860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_39865	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT06_39880	COG2226	methyltransferase
HUT06_39910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUT06_39915	COG1333	cytochrome c biogenesis protein
HUT06_39920	COG0785	Cytochrome C biogenesis protein
HUT06_39925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT06_39930	COG0406	alpha-ribazole phosphatase activity
HUT06_39945	COG0697	spore germination
HUT06_39950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT06_39955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT06_39960	COG0515	serine threonine protein kinase
HUT06_39960	COG2815	serine threonine protein kinase
HUT06_39970	COG0113	porphobilinogen synthase activity
HUT06_39975	COG1648	precorrin-2 dehydrogenase activity
HUT06_39975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT06_39980	COG0181	hydroxymethylbilane synthase activity
HUT06_39985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUT06_39990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUT06_40015	COG0560	Phosphoserine phosphatase
HUT06_40075	COG2267	carboxylic ester hydrolase activity
HUT06_40100	COG1595	DNA-templated transcription, initiation
HUT06_40130	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUT06_40150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUT06_40155	COG0506	proline dehydrogenase activity
HUT06_40160	COG1316	TRANSCRIPTIONal
HUT06_40180	COG1082	Xylose isomerase domain protein TIM barrel
HUT06_40185	COG0500	methyltransferase
HUT06_40195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUT06_40200	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUT06_40215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT06_40215	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HUT06_40225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT06_40255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT06_40270	COG1609	Transcriptional regulator
HUT06_40280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUT06_40285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT06_40295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT06_40300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT06_40305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT06_40315	COG0577	efflux transmembrane transporter activity
HUT06_40320	COG1136	(ABC) transporter
HUT06_40330	COG2197	response regulator
HUT06_40335	COG4585	Histidine kinase
HUT06_40340	COG0617	tRNA 3'-terminal CCA addition
HUT06_40345	COG2124	cytochrome p450
HUT06_40370	COG0649	NAD binding
HUT06_40380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUT06_40385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUT06_40400	COG0302	gtp cyclohydrolase
HUT06_40415	COG0037	tRNA processing
HUT06_40425	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT06_40430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT06_40435	COG3883	PFAM NLP P60 protein
HUT06_40435	COG0791	NLP P60 protein
HUT06_40470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUT06_40480	COG3397	chitin binding
HUT06_40560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUT06_40650	COG3848	Pyruvate phosphate dikinase
HUT06_40650	COG0574	Belongs to the PEP-utilizing enzyme family
HUT06_40690	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_40715	COG0028	Belongs to the TPP enzyme family
HUT06_40850	COG1309	transcriptional regulator
HUT06_40860	COG2267	carboxylic ester hydrolase activity
HUT06_40890	COG2267	carboxylic ester hydrolase activity
HUT06_40905	COG2318	DinB family
HUT06_40910	COG2226	methyltransferase
HUT06_40930	COG0167	dihydroorotate dehydrogenase activity
HUT06_40940	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT06_40985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT06_41025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT06_41030	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT06_41040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT06_41050	COG4941	Belongs to the sigma-70 factor family
HUT06_41055	COG3795	YCII-related domain
HUT06_41095	COG0022	dehydrogenase e1 component
HUT06_41100	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT06_41195	COG1960	acyl-CoA dehydrogenase activity
HUT06_41200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT06_41205	COG2076	Multidrug Resistance protein
HUT06_41220	COG4221	oxidoreductase activity
HUT06_41230	COG0604	alcohol dehydrogenase
HUT06_41230	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_41230	COG3321	synthase
HUT06_41285	COG1960	acyl-CoA dehydrogenase activity
HUT06_41290	COG3386	PFAM SMP-30 Gluconolaconase
HUT06_41300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT06_41310	COG4941	Belongs to the sigma-70 factor family
HUT06_41320	COG2409	Drug exporters of the RND superfamily
HUT06_41325	COG1595	DNA-templated transcription, initiation
HUT06_41365	COG0784	Response regulator, receiver
HUT06_41370	COG4251	negative regulation of phosphorylation
HUT06_41390	COG1136	(ABC) transporter
HUT06_41390	COG0577	efflux transmembrane transporter activity
HUT06_41395	COG0577	efflux transmembrane transporter activity
HUT06_41395	COG1136	(ABC) transporter
HUT06_41400	COG2205	protein histidine kinase activity
HUT06_41405	COG0745	RESPONSE REGULATOR receiver
HUT06_41420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUT06_41480	COG0577	efflux transmembrane transporter activity
HUT06_41480	COG1136	(ABC) transporter
HUT06_41495	COG2197	response regulator
HUT06_41525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT06_41545	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT06_41585	COG2197	response regulator
HUT06_41605	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_41655	COG1846	Transcriptional regulator
HUT06_41675	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_41685	COG1733	regulation of RNA biosynthetic process
HUT06_41695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUT06_41710	COG1960	acyl-CoA dehydrogenase activity
HUT06_41730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT06_41735	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT06_41740	COG2205	protein histidine kinase activity
HUT06_41765	COG0604	alcohol dehydrogenase
HUT06_41765	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_41765	COG3321	synthase
HUT06_41800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT06_41805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT06_41805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUT06_41830	COG2409	Drug exporters of the RND superfamily
HUT06_41835	COG1309	transcriptional regulator
HUT06_41845	COG3226	Transcriptional regulator
HUT06_41875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT06_41880	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_41885	COG2197	response regulator
HUT06_41905	COG2409	Drug exporters of the RND superfamily
HUT06_41915	COG2197	response regulator
HUT06_41925	COG1024	Enoyl-CoA hydratase
HUT06_41935	COG0515	serine threonine protein kinase
HUT06_41935	COG2815	serine threonine protein kinase
HUT06_41945	COG1595	DNA-templated transcription, initiation
HUT06_41990	COG2353	YceI-like domain
HUT06_41995	COG2205	protein histidine kinase activity
HUT06_42005	COG0745	RESPONSE REGULATOR receiver
HUT06_42010	COG2205	protein histidine kinase activity
HUT06_42025	COG2186	Transcriptional regulator
HUT06_42050	COG1595	DNA-templated transcription, initiation
HUT06_42075	COG1280	lysine exporter protein (LysE YggA)
HUT06_42080	COG1522	sequence-specific DNA binding
HUT06_42105	COG4585	Histidine kinase
HUT06_42160	COG2814	Major facilitator Superfamily
HUT06_42170	COG1846	Transcriptional regulator
HUT06_42185	COG1846	Transcriptional regulator
HUT06_42200	COG0477	Major facilitator Superfamily
HUT06_42205	COG1819	glycosyl
HUT06_42210	COG2409	Drug exporters of the RND superfamily
HUT06_42215	COG0318	PFAM AMP-dependent synthetase and ligase
HUT06_42240	COG3339	Conserved Protein
HUT06_42250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUT06_42270	COG1309	transcriptional regulator
HUT06_42305	COG1940	carbohydrate kinase activity
HUT06_42340	COG0662	Cupin 2, conserved barrel domain protein
HUT06_42355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT06_42360	COG2207	Transcriptional regulator
HUT06_42380	COG0243	molybdopterin cofactor binding
HUT06_42400	COG1119	ATPase activity
HUT06_42420	COG0675	Transposase, IS605 OrfB family
HUT06_42430	COG2197	response regulator
HUT06_42450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUT06_42455	COG0560	Phosphoserine phosphatase
HUT06_42455	COG3830	Belongs to the UPF0237 family
HUT06_42475	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUT06_42480	COG2172	sigma factor antagonist activity
HUT06_42485	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT06_42490	COG1111	helicase
HUT06_42490	COG1205	dead DEAH box helicase
HUT06_42505	COG0488	(ABC) transporter
HUT06_42565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT06_42570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT06_42580	COG0596	Alpha beta hydrolase
HUT06_42590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT06_42615	COG1028	Short-chain dehydrogenase reductase Sdr
HUT06_42635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT06_42640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT06_42665	COG2130	NADP-dependent
HUT06_42680	COG0003	Pfam Anion-transporting ATPase
HUT06_42700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT06_42710	COG1408	metallophosphoesterase
HUT06_42715	COG2226	methyltransferase
HUT06_42725	COG3547	Transposase (IS116 IS110 IS902 family)
HUT06_42760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUT06_42845	COG4974	Belongs to the 'phage' integrase family
HUT06_42885	COG1595	DNA-templated transcription, initiation
HUT06_42890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT06_42955	COG0651	ATP synthesis coupled electron transport
HUT06_42995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HUT06_43005	COG0596	Alpha beta hydrolase
HUT06_43010	COG3629	intracellular signal transduction
HUT06_43010	COG3903	Transcriptional regulator
HUT06_43015	COG0753	catalase activity
HUT06_43040	COG0583	DNA-binding transcription factor activity
HUT06_43075	COG1309	transcriptional regulator
HUT06_43105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUT06_43110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT06_43115	COG0110	maltose O-acetyltransferase activity
HUT06_43155	COG2807	transmembrane transport
HUT06_43160	COG2186	Transcriptional regulator
HUT06_43185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUT06_43210	COG0590	tRNA wobble adenosine to inosine editing
HUT06_43240	COG0592	DNA-directed DNA polymerase activity
HUT06_43285	COG2264	protein methyltransferase activity
HUT06_43310	COG1846	Transcriptional regulator
HUT06_43335	COG2409	Drug exporters of the RND superfamily
HUT06_43375	COG0305	Participates in initiation and elongation during chromosome replication
HUT06_43395	COG0359	binds to the 23S rRNA
HUT06_43400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT06_43405	COG0629	single-stranded DNA binding
HUT06_43410	COG0360	Binds together with S18 to 16S ribosomal RNA
HUT06_43425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT06_43440	COG0789	Transcriptional regulator
HUT06_43450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT06_43455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT06_43470	COG4166	transmembrane transport
HUT06_43490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT06_43495	COG0617	tRNA 3'-terminal CCA addition
HUT06_43515	COG0515	serine threonine protein kinase
HUT06_43515	COG2815	serine threonine protein kinase
HUT06_43520	COG1595	DNA-templated transcription, initiation
HUT06_43540	COG3118	belongs to the thioredoxin family
HUT06_43550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT06_43555	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT06_43570	COG1192	Involved in chromosome partitioning
HUT06_43575	COG0357	Ribosomal RNA small subunit methyltransferase G
HUT06_43595	COG0706	membrane insertase activity
HUT06_43600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT06_43605	COG0594	ribonuclease P activity
HUT06_43610	COG0230	Belongs to the bacterial ribosomal protein bL34 family