locus-tag	class	description
M3I41_00010	COG0592	DNA-directed DNA polymerase activity
M3I41_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M3I41_00025	COG0187	DNA topoisomerase II activity
M3I41_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M3I41_00070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M3I41_00085	COG3764	Sortase (surface protein transpeptidase)
M3I41_00100	COG0515	serine threonine protein kinase
M3I41_00105	COG0768	penicillin binding
M3I41_00120	COG1716	ATPase activity
M3I41_00125	COG1716	ATPase activity
M3I41_00140	COG0569	domain protein
M3I41_00140	COG2985	domain, Protein
M3I41_00145	COG0628	permease
M3I41_00155	COG1854	S-ribosylhomocysteine lyase activity
M3I41_00220	COG1100	Small GTP-binding protein
M3I41_00230	COG0443	Heat shock 70 kDa protein
M3I41_00300	COG4555	ABC transporter
M3I41_00325	COG1063	alcohol dehydrogenase
M3I41_00330	COG2274	protein secretion by the type I secretion system
M3I41_00335	COG1132	(ABC) transporter
M3I41_00370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M3I41_00375	COG0402	S-adenosylhomocysteine deaminase activity
M3I41_00385	COG0561	phosphatase activity
M3I41_00390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M3I41_00425	COG0431	NADPH-dependent FMN reductase
M3I41_00435	COG0033	Phosphoglucomutase
M3I41_00465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M3I41_00490	COG2233	PERMEase
M3I41_00520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M3I41_00535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M3I41_00535	COG0519	Catalyzes the synthesis of GMP from XMP
M3I41_00540	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M3I41_00600	COG2261	transglycosylase associated protein
M3I41_00615	COG0443	Heat shock 70 kDa protein
M3I41_00620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M3I41_00625	COG0484	heat shock protein binding
M3I41_00630	COG0789	Transcriptional regulator
M3I41_00655	COG0247	lactate metabolic process
M3I41_00655	COG2181	nitrate reductase activity
M3I41_00670	COG3842	ATPase activity
M3I41_00690	COG0577	efflux transmembrane transporter activity
M3I41_00690	COG1136	(ABC) transporter
M3I41_00700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M3I41_00705	COG4667	esterase of the alpha-beta hydrolase superfamily
M3I41_00730	COG2354	Protein conserved in bacteria
M3I41_00735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M3I41_00740	COG0113	porphobilinogen synthase activity
M3I41_00750	COG0181	hydroxymethylbilane synthase activity
M3I41_00760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M3I41_00765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M3I41_00770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M3I41_00775	COG3253	May function as heme-dependent peroxidase
M3I41_00775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M3I41_00830	COG0366	Alpha amylase catalytic
M3I41_00830	COG1470	cell adhesion involved in biofilm formation
M3I41_00840	COG0803	Belongs to the bacterial solute-binding protein 9 family
M3I41_00845	COG1121	(ABC) transporter
M3I41_00850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M3I41_00855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M3I41_00870	COG1643	Atp-dependent helicase
M3I41_00885	COG0577	efflux transmembrane transporter activity
M3I41_00885	COG1136	(ABC) transporter
M3I41_00895	COG2860	membrane
M3I41_00900	COG1131	(ABC) transporter
M3I41_00935	COG1132	(ABC) transporter
M3I41_00960	COG0717	Belongs to the dCTP deaminase family
M3I41_00970	COG2176	DNA-directed DNA polymerase activity
M3I41_00995	COG0395	ABC-type sugar transport system, permease component
M3I41_01000	COG0300	oxidoreductase activity
M3I41_01010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M3I41_01020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M3I41_01025	COG0191	fructose-bisphosphate aldolase activity
M3I41_01035	COG0477	Major facilitator Superfamily
M3I41_01045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M3I41_01090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M3I41_01160	COG2837	iron assimilation
M3I41_01165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M3I41_01175	COG2801	Transposase and inactivated derivatives
M3I41_01180	COG0151	Belongs to the GarS family
M3I41_01185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M3I41_01190	COG3291	Pkd domain containing protein
M3I41_01190	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M3I41_01200	COG0047	phosphoribosylformylglycinamidine synthase activity
M3I41_01205	COG0438	transferase activity, transferring glycosyl groups
M3I41_01210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M3I41_01230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M3I41_01245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M3I41_01290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M3I41_01310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M3I41_01310	COG1754	DNA topoisomerase type I activity
M3I41_01320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M3I41_01330	COG0483	inositol monophosphate 1-phosphatase activity
M3I41_01375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M3I41_01395	COG1362	aminopeptidase activity
M3I41_01410	COG0371	Dehydrogenase
M3I41_01420	COG0569	domain protein
M3I41_01425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M3I41_01445	COG0406	alpha-ribazole phosphatase activity
M3I41_01490	COG0714	Associated with various cellular activities
M3I41_01540	COG1674	ftsk spoiiie
M3I41_01585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M3I41_01590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M3I41_01595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M3I41_01600	COG1120	ATPase activity
M3I41_01610	COG1620	l-lactate permease
M3I41_01615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M3I41_01620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M3I41_01625	COG2390	Transcriptional regulator
M3I41_01645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M3I41_01650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M3I41_01655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M3I41_01660	COG1120	ATPase activity
M3I41_01670	COG0698	ribose 5-phosphate isomerase
M3I41_01680	COG0647	UMP catabolic process
M3I41_01685	COG1069	ribulokinase activity
M3I41_01695	COG0443	Heat shock 70 kDa protein
M3I41_01705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M3I41_01715	COG4948	Mandelate Racemase Muconate Lactonizing
M3I41_01720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M3I41_01725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M3I41_01730	COG1169	isochorismate synthase
M3I41_01735	COG2226	methyltransferase
M3I41_01745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M3I41_01750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M3I41_01755	COG0649	NAD binding
M3I41_01765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M3I41_01770	COG1034	ATP synthesis coupled electron transport
M3I41_01775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M3I41_01780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M3I41_01785	COG0839	Belongs to the complex I subunit 6 family
M3I41_01790	COG0713	ATP synthesis coupled electron transport
M3I41_01795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M3I41_01805	COG1007	ATP synthesis coupled electron transport
M3I41_01810	COG0142	geranyltranstransferase activity
M3I41_01815	COG0493	'glutamate synthase
M3I41_01820	COG1322	Protein conserved in bacteria
M3I41_01835	COG3549	Plasmid maintenance system killer
M3I41_01915	COG1397	ADP-ribosylglycohydrolase
M3I41_01950	COG1725	Transcriptional regulator
M3I41_01955	COG1131	(ABC) transporter
M3I41_02010	COG0604	alcohol dehydrogenase
M3I41_02035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M3I41_02140	COG0833	amino acid
M3I41_02155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M3I41_02160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M3I41_02170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M3I41_02185	COG1722	exodeoxyribonuclease VII activity
M3I41_02190	COG1570	exodeoxyribonuclease VII activity
M3I41_02195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M3I41_02200	COG0501	Belongs to the peptidase M48B family
M3I41_02205	COG1666	GTP binding
M3I41_02235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M3I41_02250	COG0436	Aminotransferase
M3I41_02260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M3I41_02270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M3I41_02275	COG0081	regulation of translation
M3I41_02285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M3I41_02290	COG0222	ribosome binding
M3I41_02320	COG0085	RNA polymerase activity
M3I41_02325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M3I41_02345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M3I41_02380	COG1217	gtp-binding protein TYPA
M3I41_02435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M3I41_02445	COG1316	TRANSCRIPTIONal
M3I41_02450	COG1316	TRANSCRIPTIONal
M3I41_02475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M3I41_02480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M3I41_02540	COG1132	(ABC) transporter
M3I41_02550	COG0438	transferase activity, transferring glycosyl groups
M3I41_02575	COG3754	Rhamnan synthesis protein F
M3I41_02590	COG1216	Glycosyl transferase, family 2
M3I41_02605	COG0438	transferase activity, transferring glycosyl groups
M3I41_02625	COG1216	Glycosyl transferase, family 2
M3I41_02645	COG3475	LICD family
M3I41_02655	COG0697	spore germination
M3I41_02660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M3I41_02665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M3I41_02670	COG1482	cell wall glycoprotein biosynthetic process
M3I41_02710	COG1611	Belongs to the LOG family
M3I41_02740	COG2239	Acts as a magnesium transporter
M3I41_02745	COG0006	proline dipeptidase activity
M3I41_02755	COG2095	MarC family integral membrane protein
M3I41_02760	COG0513	Belongs to the DEAD box helicase family
M3I41_02830	COG1129	ABC transporter
M3I41_02830	COG0842	Transport permease protein
M3I41_02835	COG0842	Transport permease protein
M3I41_02850	COG0583	DNA-binding transcription factor activity
M3I41_02855	COG1968	undecaprenyl-diphosphatase activity
M3I41_02860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M3I41_02885	COG1162	GTPase activity
M3I41_02890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M3I41_02900	COG1595	DNA-templated transcription, initiation
M3I41_02915	COG0567	Dehydrogenase, E1 component
M3I41_02915	COG0508	dehydrogenase complex catalyzes the overall conversion of
M3I41_02920	COG1253	flavin adenine dinucleotide binding
M3I41_02930	COG0739	heme binding
M3I41_02930	COG0741	lytic transglycosylase activity
M3I41_02930	COG1196	nuclear chromosome segregation
M3I41_02940	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M3I41_02955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M3I41_02970	COG0018	arginyl-trna synthetase
M3I41_02975	COG0460	homoserine dehydrogenase
M3I41_02980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M3I41_02985	COG0083	homoserine kinase activity
M3I41_02995	COG0254	rRNA binding
M3I41_03000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M3I41_03005	COG2890	protein-(glutamine-N5) methyltransferase activity
M3I41_03015	COG0205	6-phosphofructokinase activity
M3I41_03020	COG0045	succinate-CoA ligase (ADP-forming) activity
M3I41_03055	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M3I41_03065	COG4988	ABC transporter
M3I41_03070	COG0039	L-malate dehydrogenase activity
M3I41_03085	COG0395	ABC-type sugar transport system, permease component
M3I41_03095	COG1725	Transcriptional regulator
M3I41_03120	COG0058	SHG alpha-glucan phosphorylase activity
M3I41_03125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M3I41_03130	COG3281	Trehalose synthase
M3I41_03135	COG0366	Alpha amylase catalytic
M3I41_03140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M3I41_03145	COG1461	Dihydroxyacetone kinase
M3I41_03155	COG0742	ribosomal rna small subunit methyltransferase
M3I41_03160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M3I41_03175	COG0571	ribonuclease III activity
M3I41_03180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M3I41_03195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M3I41_03200	COG4988	ABC transporter
M3I41_03205	COG1294	oxidase, subunit
M3I41_03210	COG1271	oxidase subunit
M3I41_03215	COG1530	ribonuclease E activity
M3I41_03220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M3I41_03225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M3I41_03230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M3I41_03240	COG5426	von Willebrand factor, type A
M3I41_03245	COG1349	DNA-binding transcription factor activity
M3I41_03250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M3I41_03260	COG0799	negative regulation of ribosome biogenesis
M3I41_03265	COG0406	alpha-ribazole phosphatase activity
M3I41_03295	COG1174	glycine betaine transport
M3I41_03300	COG1174	glycine betaine transport
M3I41_03315	COG0114	fumarate hydratase activity
M3I41_03330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M3I41_03345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M3I41_03350	COG1263	PTS System
M3I41_03355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M3I41_03360	COG2190	(PTS) system
M3I41_03370	COG3590	peptidase
M3I41_03390	COG1045	serine acetyltransferase
M3I41_03405	COG1739	Uncharacterized protein family UPF0029
M3I41_03430	COG0544	peptidyl-prolyl cis-trans isomerase activity
M3I41_03450	COG0740	serine-type endopeptidase activity
M3I41_03455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M3I41_03465	COG0395	ABC-type sugar transport system, permease component
M3I41_03470	COG1175	transmembrane transport
M3I41_03480	COG0673	inositol 2-dehydrogenase activity
M3I41_03490	COG4555	ABC transporter
M3I41_03505	COG1162	GTPase activity
M3I41_03525	COG0285	dihydrofolate synthase activity
M3I41_03545	COG0105	UTP biosynthetic process
M3I41_03555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M3I41_03565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M3I41_03570	COG0730	response to heat
M3I41_03575	COG0561	phosphatase activity
M3I41_03580	COG0656	L-ascorbic acid biosynthetic process
M3I41_03585	COG0733	neurotransmitter:sodium symporter activity
M3I41_03610	COG0537	adenosine 5'-monophosphoramidase activity
M3I41_03635	COG0297	glycogen (starch) synthase activity
M3I41_03640	COG1119	ATPase activity
M3I41_03665	COG1121	(ABC) transporter
M3I41_03685	COG0488	(ABC) transporter
M3I41_03725	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M3I41_03735	COG0142	geranyltranstransferase activity
M3I41_03745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M3I41_03755	COG0187	DNA topoisomerase II activity
M3I41_03775	COG0339	signal peptide processing
M3I41_03795	COG0667	Aldo Keto reductase
M3I41_03810	COG1222	aaa ATPase
M3I41_03815	COG4122	O-methyltransferase activity
M3I41_03825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M3I41_03845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M3I41_03875	COG0539	negative regulation of cytoplasmic translation
M3I41_03880	COG2056	Na+-H+ antiporter family
M3I41_03895	COG2095	MarC family integral membrane protein
M3I41_03955	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M3I41_03995	COG2801	Transposase and inactivated derivatives
M3I41_04065	COG0556	nucleotide-excision repair
M3I41_04075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M3I41_04090	COG1175	transmembrane transport
M3I41_04095	COG3833	ABC-type maltose transport systems, permease component
M3I41_04150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M3I41_04160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M3I41_04165	COG1560	Kdo2-lipid A biosynthetic process
M3I41_04170	COG0438	transferase activity, transferring glycosyl groups
M3I41_04190	COG0217	transcriptional regulatory protein
M3I41_04195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M3I41_04200	COG0632	four-way junction helicase activity
M3I41_04205	COG2255	four-way junction helicase activity
M3I41_04215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M3I41_04220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M3I41_04225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M3I41_04235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M3I41_04240	COG1196	nuclear chromosome segregation
M3I41_04245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M3I41_04250	COG0124	histidyl-tRNA synthetase
M3I41_04275	COG2801	Transposase and inactivated derivatives
M3I41_04285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M3I41_04290	COG0009	L-threonylcarbamoyladenylate synthase
M3I41_04295	COG2409	Drug exporters of the RND superfamily
M3I41_04305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M3I41_04310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M3I41_04315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M3I41_04330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M3I41_04335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M3I41_04345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M3I41_04350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M3I41_04355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M3I41_04360	COG0540	Belongs to the ATCase OTCase family
M3I41_04365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M3I41_04370	COG0284	orotidine-5'-phosphate decarboxylase activity
M3I41_04380	COG0194	GDP metabolic process
M3I41_04385	COG1758	RNA polymerase activity
M3I41_04395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M3I41_04405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M3I41_04415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M3I41_04420	COG4770	biotin carboxylase activity
M3I41_04425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M3I41_04430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M3I41_04435	COG0736	holo-[acyl-carrier-protein] synthase activity
M3I41_04440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M3I41_04445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M3I41_04470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M3I41_04475	COG0805	protein transport
M3I41_04490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M3I41_04495	COG1216	Glycosyl transferase, family 2
M3I41_04505	COG0205	6-phosphofructokinase activity
M3I41_04510	COG1247	-acetyltransferase
M3I41_04520	COG1609	Transcriptional regulator
M3I41_04525	COG2190	(PTS) system
M3I41_04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M3I41_04525	COG1263	PTS System
M3I41_04530	COG1621	beta-fructofuranosidase activity
M3I41_04555	COG1716	ATPase activity
M3I41_04580	COG0561	phosphatase activity
M3I41_04585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M3I41_04590	COG1643	Atp-dependent helicase
M3I41_04595	COG0028	Belongs to the TPP enzyme family
M3I41_04610	COG4191	Histidine kinase
M3I41_04635	COG2814	Major facilitator Superfamily
M3I41_04670	COG1160	GTP binding
M3I41_04680	COG1187	pseudouridine synthase activity
M3I41_04695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M3I41_04700	COG0149	triose-phosphate isomerase activity
M3I41_04710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M3I41_04715	COG1481	regulation of sporulation
M3I41_04720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M3I41_04725	COG1660	Displays ATPase and GTPase activities
M3I41_04730	COG0322	excinuclease ABC activity
M3I41_04760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M3I41_04770	COG1882	Formate acetyltransferase
M3I41_04775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M3I41_04780	COG0657	acetylesterase activity
M3I41_04790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M3I41_04795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M3I41_04800	COG0508	dehydrogenase complex catalyzes the overall conversion of
M3I41_04825	COG0321	lipoyl(octanoyl) transferase activity
M3I41_04830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M3I41_04840	COG0174	glutamine synthetase
M3I41_04850	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M3I41_04850	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M3I41_04910	COG0671	phosphoesterase, PA-phosphatase related
M3I41_04915	COG4221	oxidoreductase activity
M3I41_04920	COG1881	PFAM PEBP family protein
M3I41_04925	COG3842	ATPase activity
M3I41_04935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M3I41_04995	COG0531	amino acid
M3I41_05000	COG0569	domain protein
M3I41_05035	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M3I41_05040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M3I41_05045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M3I41_05050	COG0765	amino acid transport
M3I41_05055	COG1126	abc transporter atp-binding protein
M3I41_05065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M3I41_05075	COG0174	glutamine synthetase
M3I41_05080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M3I41_05100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M3I41_05115	COG3022	response to hydroperoxide
M3I41_05130	COG1181	Belongs to the D-alanine--D-alanine ligase family
M3I41_05140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M3I41_05150	COG0438	transferase activity, transferring glycosyl groups
M3I41_05155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M3I41_05165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M3I41_05180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M3I41_05185	COG2813	Specifically methylates the guanine in position
M3I41_05195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M3I41_05205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M3I41_05210	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M3I41_05215	COG2137	regulation of response to DNA damage stimulus
M3I41_05220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M3I41_05235	COG1058	Belongs to the CinA family
M3I41_05235	COG1546	Belongs to the CinA family
M3I41_05245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M3I41_05250	COG1381	Involved in DNA repair and RecF pathway recombination
M3I41_05255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M3I41_05270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M3I41_05280	COG1902	pentaerythritol trinitrate reductase activity
M3I41_05290	COG0484	heat shock protein binding
M3I41_05295	COG1420	regulation of RNA biosynthetic process
M3I41_05310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M3I41_05320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M3I41_05325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M3I41_05335	COG0028	Belongs to the TPP enzyme family
M3I41_05340	COG0569	domain protein
M3I41_05340	COG2985	domain, Protein
M3I41_05350	COG2501	S4 domain
M3I41_05355	COG0587	DNA-directed DNA polymerase activity
M3I41_05385	COG1799	cell septum assembly
M3I41_05390	COG1496	oxidoreductase activity
M3I41_05395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M3I41_05405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M3I41_05420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M3I41_05425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M3I41_05430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M3I41_05435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M3I41_05440	COG0768	penicillin binding
M3I41_05450	COG0275	rRNA processing
M3I41_05455	COG2001	Belongs to the MraZ family
M3I41_05465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M3I41_05490	COG0318	PFAM AMP-dependent synthetase and ligase
M3I41_05500	COG0612	Peptidase, M16
M3I41_05505	COG1131	(ABC) transporter
M3I41_05520	COG1185	polyribonucleotide nucleotidyltransferase activity
M3I41_05545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M3I41_05555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M3I41_05555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M3I41_05565	COG0779	Required for maturation of 30S ribosomal subunits
M3I41_05575	COG0442	prolyl-tRNA aminoacylation
M3I41_05585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M3I41_05590	COG0750	zinc metalloprotease
M3I41_05595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M3I41_05605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M3I41_05610	COG0575	Belongs to the CDS family
M3I41_05615	COG0233	cytoplasmic translational termination
M3I41_05625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M3I41_05630	COG0052	Belongs to the universal ribosomal protein uS2 family
M3I41_05635	COG1113	amino acid transport
M3I41_05645	COG4974	Belongs to the 'phage' integrase family
M3I41_05660	COG0792	nuclease activity
M3I41_05675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M3I41_05680	COG0681	Belongs to the peptidase S26 family
M3I41_05685	COG0335	large ribosomal subunit rRNA binding
M3I41_05695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M3I41_05700	COG1837	Belongs to the UPF0109 family
M3I41_05710	COG1131	(ABC) transporter
M3I41_05720	COG4585	Histidine kinase
M3I41_05725	COG2197	response regulator
M3I41_05740	COG4868	Belongs to the UPF0371 family
M3I41_05755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M3I41_05760	COG0481	GTPase activity
M3I41_05770	COG0268	Binds directly to 16S ribosomal RNA
M3I41_05785	COG1596	polysaccharide export
M3I41_05785	COG1555	photosystem II stabilization
M3I41_05795	COG0783	Belongs to the Dps family
M3I41_05805	COG0495	leucyl-tRNA aminoacylation
M3I41_05825	COG0423	glycine-tRNA ligase activity
M3I41_05840	COG1116	anion transmembrane transporter activity
M3I41_05845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M3I41_05885	COG0488	(ABC) transporter
M3I41_05900	COG1002	Type II restriction enzyme, methylase subunits
M3I41_05960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M3I41_05965	COG0512	Glutamine amidotransferase of anthranilate synthase
M3I41_05980	COG0159	tryptophan synthase activity
M3I41_05985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M3I41_05995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M3I41_06025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M3I41_06030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M3I41_06040	COG1115	amino acid carrier protein
M3I41_06045	COG1115	amino acid carrier protein
M3I41_06055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M3I41_06060	COG3304	Inner membrane component domain
M3I41_06095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M3I41_06100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M3I41_06105	COG1234	tRNA 3'-trailer cleavage
M3I41_06130	COG0363	glucosamine-6-phosphate deaminase activity
M3I41_06150	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M3I41_06160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M3I41_06165	COG4608	Belongs to the ABC transporter superfamily
M3I41_06190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M3I41_06190	COG2169	Transcriptional regulator
M3I41_06200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M3I41_06215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M3I41_06220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M3I41_06255	COG2177	Part of the ABC transporter FtsEX involved in
M3I41_06260	COG2884	Cell division ATP-binding protein ftsE
M3I41_06300	COG1615	UPF0182 protein
M3I41_06315	COG3480	Lon protease (S16) C-terminal proteolytic domain
M3I41_06335	COG1104	cysteine desulfurase activity
M3I41_06350	COG0482	sulfurtransferase activity
M3I41_06355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M3I41_06380	COG1002	Type II restriction enzyme, methylase subunits
M3I41_06395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M3I41_06400	COG1027	Aspartate ammonia-lyase
M3I41_06410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M3I41_06450	COG0358	DNA primase activity
M3I41_06465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M3I41_06475	COG0167	dihydroorotate dehydrogenase activity
M3I41_06500	COG0822	iron-sulfur transferase activity
M3I41_06510	COG0396	ATPase activity
M3I41_06515	COG0719	Fe-S assembly protein
M3I41_06535	COG0494	nUDIX hydrolase
M3I41_06540	COG0504	CTP synthase activity
M3I41_06570	COG0497	DNA recombination
M3I41_06575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M3I41_06610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M3I41_06615	COG1438	arginine binding
M3I41_06630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M3I41_06635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M3I41_06640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M3I41_06645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M3I41_06655	COG0697	spore germination
M3I41_06695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M3I41_06700	COG0154	amidase activity
M3I41_06705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M3I41_06715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M3I41_06720	COG1674	ftsk spoiiie
M3I41_06750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M3I41_06760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M3I41_06765	COG0420	3'-5' exonuclease activity
M3I41_06770	COG0419	ATPase involved in DNA repair
M3I41_06810	COG0653	protein targeting
M3I41_06820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M3I41_06825	COG5401	PFAM Sporulation and spore germination
M3I41_06830	COG5002	protein histidine kinase activity
M3I41_06830	COG5000	phosphorelay sensor kinase activity
M3I41_06835	COG0745	RESPONSE REGULATOR receiver
M3I41_06855	COG0714	Associated with various cellular activities
M3I41_06860	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M3I41_06895	COG0549	Belongs to the carbamate kinase family
M3I41_06900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M3I41_06915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M3I41_06940	COG0577	efflux transmembrane transporter activity
M3I41_06940	COG1136	(ABC) transporter
M3I41_06945	COG0577	efflux transmembrane transporter activity
M3I41_06945	COG1136	(ABC) transporter
M3I41_06965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M3I41_06970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M3I41_06975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M3I41_06985	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M3I41_06995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M3I41_07000	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M3I41_07005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M3I41_07010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M3I41_07015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M3I41_07020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M3I41_07025	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M3I41_07030	COG0356	it plays a direct role in the translocation of protons across the membrane
M3I41_07055	COG2197	response regulator
M3I41_07060	COG2205	protein histidine kinase activity
M3I41_07095	COG3177	Filamentation induced by cAMP protein fic
M3I41_07100	COG0281	malic enzyme
M3I41_07105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M3I41_07115	COG1573	uracil-dna glycosylase
M3I41_07125	COG1131	(ABC) transporter
M3I41_07190	COG2184	nucleotidyltransferase activity
M3I41_07245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M3I41_07245	COG0519	Catalyzes the synthesis of GMP from XMP
M3I41_07250	COG0673	inositol 2-dehydrogenase activity
M3I41_07285	COG3718	enzyme involved in inositol metabolism
M3I41_07300	COG2188	Transcriptional regulator
M3I41_07305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M3I41_07310	COG0673	inositol 2-dehydrogenase activity
M3I41_07325	COG1609	Transcriptional regulator
M3I41_07330	COG0673	inositol 2-dehydrogenase activity
M3I41_07335	COG2814	Major facilitator Superfamily
M3I41_07355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M3I41_07360	COG0328	RNA-DNA hybrid ribonuclease activity
M3I41_07365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M3I41_07390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M3I41_07405	COG1132	(ABC) transporter
M3I41_07410	COG1132	(ABC) transporter
M3I41_07415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M3I41_07420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M3I41_07425	COG1053	succinate dehydrogenase
M3I41_07435	COG0456	acetyltransferase
M3I41_07450	COG0802	atpase or kinase
M3I41_07455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M3I41_07470	COG1072	(Pantothenic acid kinase))
M3I41_07480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M3I41_07485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M3I41_07530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M3I41_07535	COG0203	ribosomal protein L17
M3I41_07540	COG0202	RNA polymerase activity
M3I41_07545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M3I41_07550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M3I41_07555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M3I41_07560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M3I41_07570	COG0563	adenylate kinase activity
M3I41_07575	COG0201	protein transport
M3I41_07580	COG0200	Binds to the 23S rRNA
M3I41_07585	COG1841	ribosomal large subunit assembly
M3I41_07590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M3I41_07595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M3I41_07600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M3I41_07610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M3I41_07615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M3I41_07620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M3I41_07625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M3I41_07630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M3I41_07635	COG0255	Belongs to the universal ribosomal protein uL29 family
M3I41_07640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M3I41_07645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M3I41_07650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M3I41_07655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M3I41_07660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M3I41_07665	COG0089	rRNA binding
M3I41_07680	COG0051	transcription antitermination factor activity, RNA binding
M3I41_07695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M3I41_07700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M3I41_07705	COG0049	tRNA binding
M3I41_07710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M3I41_07720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M3I41_07725	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M3I41_07730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M3I41_07740	COG0577	efflux transmembrane transporter activity
M3I41_07740	COG1136	(ABC) transporter
M3I41_07745	COG1136	(ABC) transporter
M3I41_07750	COG2826	transposase and inactivated derivatives, IS30 family
M3I41_07785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M3I41_07795	COG0302	gtp cyclohydrolase
M3I41_07800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M3I41_07810	COG2027	D-alanyl-D-alanine carboxypeptidase
M3I41_07815	COG0477	Major facilitator Superfamily
M3I41_07825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M3I41_07830	COG3883	PFAM NLP P60 protein
M3I41_07830	COG0791	NLP P60 protein
M3I41_07835	COG1472	Belongs to the glycosyl hydrolase 3 family
M3I41_07840	COG2267	carboxylic ester hydrolase activity
M3I41_07850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M3I41_07850	COG0574	Belongs to the PEP-utilizing enzyme family
M3I41_07865	COG1490	D-aminoacyl-tRNA deacylase activity
M3I41_07880	COG3485	protocatechuate 3,4-dioxygenase
M3I41_07890	COG0745	RESPONSE REGULATOR receiver
M3I41_07895	COG0110	maltose O-acetyltransferase activity
M3I41_07930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M3I41_07940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M3I41_07950	COG2226	methyltransferase
M3I41_07965	COG1136	(ABC) transporter
M3I41_07975	COG1230	cation diffusion facilitator family transporter
M3I41_07990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M3I41_07995	COG0129	dihydroxy-acid dehydratase activity
M3I41_08000	COG1316	TRANSCRIPTIONal
M3I41_08005	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M3I41_08010	COG0193	aminoacyl-tRNA hydrolase activity
M3I41_08015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M3I41_08020	COG2197	response regulator
M3I41_08035	COG1131	(ABC) transporter
M3I41_08055	COG1132	(ABC) transporter
M3I41_08070	COG0545	Peptidyl-prolyl cis-trans isomerase
M3I41_08075	COG0489	protein tyrosine kinase activity
M3I41_08100	COG0710	3-dehydroquinate dehydratase activity
M3I41_08120	COG0148	phosphopyruvate hydratase activity
M3I41_08165	COG1083	cytidylyl-transferase
M3I41_08170	COG2089	acid synthase
M3I41_08180	COG0438	transferase activity, transferring glycosyl groups
M3I41_08195	COG0438	transferase activity, transferring glycosyl groups
M3I41_08220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M3I41_08240	COG0488	(ABC) transporter
M3I41_08245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M3I41_08260	COG0494	nUDIX hydrolase
M3I41_08285	COG5650	phosphatidylinositol metabolic process
M3I41_08300	COG0084	hydrolase, TatD family'
M3I41_08305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M3I41_08325	COG1335	isochorismatase
M3I41_08370	COG0252	asparaginase activity
M3I41_08375	COG1113	amino acid transport
M3I41_08400	COG0789	Transcriptional regulator
M3I41_08415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M3I41_08420	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M3I41_08460	COG2826	transposase and inactivated derivatives, IS30 family
M3I41_08465	COG1131	(ABC) transporter
M3I41_08495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M3I41_08520	COG0475	glutathione-regulated potassium exporter activity
M3I41_08535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M3I41_08540	COG2226	methyltransferase
M3I41_08565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M3I41_08575	COG1970	mechanosensitive ion channel activity
M3I41_08590	COG1309	transcriptional regulator
M3I41_08600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M3I41_08600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M3I41_08620	COG4172	Belongs to the ABC transporter superfamily
M3I41_08625	COG0747	negative chemotaxis
M3I41_08635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M3I41_08660	COG2885	chlorophyll binding
M3I41_08675	COG0791	NLP P60 protein
M3I41_08680	COG1321	iron dependent repressor
M3I41_08690	COG2252	PERMEase
M3I41_08705	COG0505	Belongs to the CarA family
M3I41_08715	COG1842	Phage shock protein A
M3I41_08725	COG0745	RESPONSE REGULATOR receiver
M3I41_08730	COG2205	protein histidine kinase activity
M3I41_08745	COG1376	ErfK ybiS ycfS ynhG family protein
M3I41_08760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M3I41_08780	COG0166	Belongs to the GPI family
M3I41_08790	COG3842	ATPase activity
M3I41_08815	COG0215	cysteine-tRNA ligase activity
M3I41_08820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M3I41_08825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M3I41_08835	COG0588	phosphoglycerate mutase activity
M3I41_08870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M3I41_08875	COG1464	Belongs to the NlpA lipoprotein family
M3I41_08880	COG2011	ABC-type metal ion transport system permease component
M3I41_08885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M3I41_08915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M3I41_08925	COG1780	Probably involved in ribonucleotide reductase function
M3I41_08935	COG2205	protein histidine kinase activity
M3I41_08940	COG0745	RESPONSE REGULATOR receiver
M3I41_08945	COG1760	l-serine dehydratase
M3I41_08950	COG0351	phosphomethylpyrimidine kinase
M3I41_08955	COG0534	Mate efflux family protein
M3I41_08960	COG0305	Participates in initiation and elongation during chromosome replication
M3I41_08965	COG0359	binds to the 23S rRNA
M3I41_08970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M3I41_08980	COG0360	Binds together with S18 to 16S ribosomal RNA
M3I41_08985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M3I41_08995	COG0617	tRNA 3'-terminal CCA addition
M3I41_09000	COG0494	nUDIX hydrolase
M3I41_09015	COG0492	ferredoxin-NADP+ reductase activity
M3I41_09020	COG3118	belongs to the thioredoxin family
M3I41_09025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M3I41_09030	COG1181	Belongs to the D-alanine--D-alanine ligase family
M3I41_09035	COG1114	Component of the transport system for branched-chain amino acids
M3I41_09050	COG1132	(ABC) transporter
M3I41_09050	COG2375	cellular response to nickel ion
M3I41_09055	COG1129	ABC transporter
M3I41_09075	COG1192	Involved in chromosome partitioning
M3I41_09085	COG0357	Ribosomal RNA small subunit methyltransferase G
M3I41_09095	COG0706	membrane insertase activity
M3I41_09100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M3I41_09105	COG0594	ribonuclease P activity
M3I41_09110	COG0230	Belongs to the bacterial ribosomal protein bL34 family