locus-tag	class	description
AN27039_0005	COG0569	domain protein
AN27039_0005	COG2985	domain, Protein
AN27039_0006	COG2966	Psort location CytoplasmicMembrane, score
AN27039_0011	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN27039_0012	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN27039_0013	COG0154	amidase activity
AN27039_0014	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN27039_0017	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN27039_0018	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN27039_0020	COG1674	ftsk spoiiie
AN27039_0028	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AN27039_0034	COG1174	glycine betaine transport
AN27039_0035	COG1125	glycine betaine transport
AN27039_0036	COG0346	lactoylglutathione lyase activity
AN27039_0041	COG0114	fumarate hydratase activity
AN27039_0051	COG0513	Belongs to the DEAD box helicase family
AN27039_0052	COG2095	MarC family integral membrane protein
AN27039_0055	COG0006	proline dipeptidase activity
AN27039_0056	COG0006	proline dipeptidase activity
AN27039_0060	COG1082	Xylose isomerase domain protein TIM barrel
AN27039_0063	COG2239	Acts as a magnesium transporter
AN27039_0067	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN27039_0070	COG1611	Belongs to the LOG family
AN27039_0071	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN27039_0072	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN27039_0076	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN27039_0076	COG1321	iron dependent repressor
AN27039_0077	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN27039_0078	COG1121	(ABC) transporter
AN27039_0096	COG1349	DNA-binding transcription factor activity
AN27039_0098	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AN27039_0102	COG1136	(ABC) transporter
AN27039_0102	COG0577	efflux transmembrane transporter activity
AN27039_0103	COG1136	(ABC) transporter
AN27039_0103	COG0577	efflux transmembrane transporter activity
AN27039_0105	COG1254	Belongs to the acylphosphatase family
AN27039_0110	COG1621	beta-fructofuranosidase activity
AN27039_0111	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN27039_0115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN27039_0116	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN27039_0117	COG0254	rRNA binding
AN27039_0118	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN27039_0120	COG0788	formyltetrahydrofolate deformylase activity
AN27039_0126	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AN27039_0129	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AN27039_0130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AN27039_0132	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AN27039_0133	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AN27039_0134	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN27039_0135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN27039_0138	COG0356	it plays a direct role in the translocation of protons across the membrane
AN27039_0141	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN27039_0145	COG2197	response regulator
AN27039_0146	COG2205	protein histidine kinase activity
AN27039_0151	COG0693	protein deglycase activity
AN27039_0156	COG1401	restriction endodeoxyribonuclease activity
AN27039_0157	COG1401	restriction endodeoxyribonuclease activity
AN27039_0160	COG3654	unkown
AN27039_0162	COG2267	carboxylic ester hydrolase activity
AN27039_0164	COG0596	Alpha beta hydrolase
AN27039_0166	COG1733	regulation of RNA biosynthetic process
AN27039_0173	COG2197	response regulator
AN27039_0174	COG2197	response regulator
AN27039_0175	COG4585	Histidine kinase
AN27039_0176	COG1131	(ABC) transporter
AN27039_0180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN27039_0180	COG0519	Catalyzes the synthesis of GMP from XMP
AN27039_0181	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN27039_0181	COG0519	Catalyzes the synthesis of GMP from XMP
AN27039_0183	COG1063	alcohol dehydrogenase
AN27039_0188	COG2814	Major facilitator Superfamily
AN27039_0190	COG3962	Belongs to the TPP enzyme family
AN27039_0191	COG3718	enzyme involved in inositol metabolism
AN27039_0198	COG2188	Transcriptional regulator
AN27039_0199	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN27039_0201	COG0673	inositol 2-dehydrogenase activity
AN27039_0202	COG2017	converts alpha-aldose to the beta-anomer
AN27039_0203	COG1609	Transcriptional regulator
AN27039_0204	COG0673	inositol 2-dehydrogenase activity
AN27039_0205	COG2814	Major facilitator Superfamily
AN27039_0206	COG2814	Major facilitator Superfamily
AN27039_0207	COG2814	Major facilitator Superfamily
AN27039_0208	COG1082	Xylose isomerase domain protein TIM barrel
AN27039_0217	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AN27039_0219	COG1131	(ABC) transporter
AN27039_0223	COG4585	Histidine kinase
AN27039_0224	COG2197	response regulator
AN27039_0229	COG4975	Glucose uptake
AN27039_0230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN27039_0231	COG0516	GMP reductase activity
AN27039_0238	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN27039_0239	COG2949	membrane
AN27039_0241	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AN27039_0242	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AN27039_0247	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AN27039_0248	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN27039_0249	COG1053	succinate dehydrogenase
AN27039_0254	COG0802	atpase or kinase
AN27039_0256	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN27039_0257	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN27039_0260	COG0736	holo-[acyl-carrier-protein] synthase activity
AN27039_0262	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN27039_0263	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN27039_0264	COG1072	(Pantothenic acid kinase))
AN27039_0265	COG0596	Alpha beta hydrolase
AN27039_0274	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AN27039_0277	COG0101	tRNA pseudouridine synthase activity
AN27039_0280	COG1285	pathogenesis
AN27039_0284	COG0228	four-way junction DNA binding
AN27039_0285	COG0202	RNA polymerase activity
AN27039_0286	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AN27039_0287	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN27039_0288	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN27039_0289	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN27039_0290	COG0024	Methionine aminopeptidase
AN27039_0291	COG0563	adenylate kinase activity
AN27039_0294	COG1841	ribosomal large subunit assembly
AN27039_0295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AN27039_0296	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AN27039_0297	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AN27039_0298	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AN27039_0299	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN27039_0300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN27039_0301	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AN27039_0302	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AN27039_0303	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AN27039_0304	COG0255	Belongs to the universal ribosomal protein uL29 family
AN27039_0305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AN27039_0306	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AN27039_0307	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AN27039_0308	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AN27039_0309	COG0089	rRNA binding
AN27039_0311	COG0088	Forms part of the polypeptide exit tunnel
AN27039_0312	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AN27039_0313	COG0051	transcription antitermination factor activity, RNA binding
AN27039_0320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN27039_0321	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN27039_0322	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN27039_0324	COG0049	tRNA binding
AN27039_0325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AN27039_0329	COG2894	cell division
AN27039_0339	COG2885	chlorophyll binding
AN27039_0348	COG0081	regulation of translation
AN27039_0350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN27039_0351	COG0436	Aminotransferase
AN27039_0354	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AN27039_0355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AN27039_0357	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN27039_0358	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN27039_0364	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN27039_0364	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AN27039_0364	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN27039_0365	COG1461	Dihydroxyacetone kinase
AN27039_0366	COG2376	Dihydroxyacetone kinase
AN27039_0373	COG2814	Major facilitator Superfamily
AN27039_0377	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AN27039_0383	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AN27039_0386	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN27039_0387	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AN27039_0388	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AN27039_0389	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN27039_0391	COG2217	Heavy metal translocating P-type atpase
AN27039_0392	COG2217	Heavy metal translocating P-type atpase
AN27039_0392	COG2608	mercury ion transmembrane transporter activity
AN27039_0393	COG1620	l-lactate permease
AN27039_0394	COG1620	l-lactate permease
AN27039_0396	COG0247	lactate metabolic process
AN27039_0397	COG1139	Iron-sulfur cluster binding protein
AN27039_0399	COG1556	Lactate utilization protein
AN27039_0402	COG3104	oligopeptide transport
AN27039_0403	COG3104	oligopeptide transport
AN27039_0405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AN27039_0414	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AN27039_0416	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN27039_0419	COG4592	Periplasmic binding protein
AN27039_0421	COG1120	ATPase activity
AN27039_0423	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_0424	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_0425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_0426	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_0428	COG1136	(ABC) transporter
AN27039_0433	COG3599	regulation of cell shape
AN27039_0438	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AN27039_0440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AN27039_0441	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AN27039_0451	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AN27039_0452	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AN27039_0455	COG0577	efflux transmembrane transporter activity
AN27039_0455	COG1136	(ABC) transporter
AN27039_0456	COG1136	(ABC) transporter
AN27039_0459	COG2197	response regulator
AN27039_0461	COG2076	Multidrug Resistance protein
AN27039_0464	COG0302	gtp cyclohydrolase
AN27039_0466	COG0302	gtp cyclohydrolase
AN27039_0467	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN27039_0477	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN27039_0480	COG2873	o-acetylhomoserine
AN27039_0481	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN27039_0482	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN27039_0488	COG0012	GTP binding
AN27039_0492	COG1322	Protein conserved in bacteria
AN27039_0493	COG2261	transglycosylase associated protein
AN27039_0495	COG1302	Protein conserved in bacteria
AN27039_0501	COG1595	DNA-templated transcription, initiation
AN27039_0504	COG0833	amino acid
AN27039_0505	COG0833	amino acid
AN27039_0506	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AN27039_0507	COG1570	exodeoxyribonuclease VII activity
AN27039_0508	COG1722	exodeoxyribonuclease VII activity
AN27039_0513	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN27039_0521	COG1472	Belongs to the glycosyl hydrolase 3 family
AN27039_0529	COG1136	(ABC) transporter
AN27039_0530	COG0577	efflux transmembrane transporter activity
AN27039_0532	COG1132	(ABC) transporter
AN27039_0533	COG1132	(ABC) transporter
AN27039_0538	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AN27039_0539	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AN27039_0542	COG0557	exoribonuclease II activity
AN27039_0545	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AN27039_0545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN27039_0545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN27039_0548	COG1105	Belongs to the carbohydrate kinase PfkB family
AN27039_0549	COG1349	DNA-binding transcription factor activity
AN27039_0551	COG0737	Belongs to the 5'-nucleotidase family
AN27039_0551	COG1525	nuclease
AN27039_0551	COG4085	toxin activity
AN27039_0552	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN27039_0560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN27039_0561	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN27039_0567	COG0047	phosphoribosylformylglycinamidine synthase activity
AN27039_0573	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN27039_0574	COG0151	Belongs to the GarS family
AN27039_0575	COG0151	Belongs to the GarS family
AN27039_0591	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN27039_0597	COG0191	fructose-bisphosphate aldolase activity
AN27039_0598	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN27039_0599	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AN27039_0600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AN27039_0601	COG1028	Short-chain dehydrogenase reductase Sdr
AN27039_0606	COG0717	Belongs to the dCTP deaminase family
AN27039_0618	COG0714	Associated with various cellular activities
AN27039_0628	COG1051	belongs to the nudix hydrolase family
AN27039_0636	COG2860	membrane
AN27039_0637	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AN27039_0644	COG1643	Atp-dependent helicase
AN27039_0645	COG1643	Atp-dependent helicase
AN27039_0646	COG1643	Atp-dependent helicase
AN27039_0647	COG3547	Transposase (IS116 IS110 IS902 family)
AN27039_0648	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN27039_0649	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN27039_0654	COG0393	Putative heavy-metal-binding
AN27039_0657	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AN27039_0660	COG0745	RESPONSE REGULATOR receiver
AN27039_0661	COG5002	protein histidine kinase activity
AN27039_0663	COG0588	phosphoglycerate mutase activity
AN27039_0665	COG1113	amino acid transport
AN27039_0666	COG0252	asparaginase activity
AN27039_0679	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AN27039_0681	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN27039_0690	COG2885	chlorophyll binding
AN27039_0692	COG0642	Histidine kinase
AN27039_0693	COG0745	RESPONSE REGULATOR receiver
AN27039_0695	COG1754	DNA topoisomerase type I activity
AN27039_0695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN27039_0698	COG0745	RESPONSE REGULATOR receiver
AN27039_0700	COG2205	protein histidine kinase activity
AN27039_0706	COG2890	protein-(glutamine-N5) methyltransferase activity
AN27039_0708	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN27039_0709	COG0450	alkyl hydroperoxide reductase
AN27039_0726	COG3548	integral membrane protein
AN27039_0731	COG0577	efflux transmembrane transporter activity
AN27039_0731	COG1136	(ABC) transporter
AN27039_0736	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AN27039_0738	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AN27039_0739	COG1408	metallophosphoesterase
AN27039_0740	COG1028	Short-chain dehydrogenase reductase Sdr
AN27039_0744	COG1597	lipid kinase activity
AN27039_0749	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AN27039_0749	COG1918	ferrous iron import across plasma membrane
AN27039_0750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AN27039_0751	COG1918	ferrous iron import across plasma membrane
AN27039_0751	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AN27039_0753	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AN27039_0753	COG1918	ferrous iron import across plasma membrane
AN27039_0755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AN27039_0755	COG1918	ferrous iron import across plasma membrane
AN27039_0761	COG0783	Belongs to the Dps family
AN27039_0771	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AN27039_0772	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AN27039_0773	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AN27039_0775	COG0181	hydroxymethylbilane synthase activity
AN27039_0777	COG0113	porphobilinogen synthase activity
AN27039_0778	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AN27039_0780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN27039_0784	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN27039_0790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN27039_0802	COG2233	PERMEase
AN27039_0808	COG0702	epimerase
AN27039_0815	COG1643	Atp-dependent helicase
AN27039_0816	COG1643	Atp-dependent helicase
AN27039_0818	COG1643	Atp-dependent helicase
AN27039_0820	COG0037	tRNA processing
AN27039_0820	COG0590	tRNA wobble adenosine to inosine editing
AN27039_0821	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN27039_0822	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN27039_0823	COG0656	L-ascorbic acid biosynthetic process
AN27039_0824	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AN27039_0830	COG4585	Histidine kinase
AN27039_0833	COG0577	efflux transmembrane transporter activity
AN27039_0833	COG1136	(ABC) transporter
AN27039_0835	COG1464	Belongs to the NlpA lipoprotein family
AN27039_0836	COG2011	ABC-type metal ion transport system permease component
AN27039_0839	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AN27039_0848	COG0463	Glycosyl transferase, family 2
AN27039_0851	COG1309	transcriptional regulator
AN27039_0865	COG0033	Phosphoglucomutase
AN27039_0868	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN27039_0869	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN27039_0870	COG1950	PFAM Membrane protein of
AN27039_0874	COG2813	Specifically methylates the guanine in position
AN27039_0881	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN27039_0894	COG2197	response regulator
AN27039_0896	COG1937	Protein conserved in bacteria
AN27039_0911	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AN27039_0914	COG0626	cystathionine gamma-synthase activity
AN27039_0915	COG0596	Alpha beta hydrolase
AN27039_0924	COG1653	transport
AN27039_0925	COG0561	phosphatase activity
AN27039_0926	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AN27039_0931	COG1309	transcriptional regulator
AN27039_0933	COG2837	iron assimilation
AN27039_0935	COG0672	)-iron permease
AN27039_0949	COG1072	(Pantothenic acid kinase))
AN27039_0951	COG0385	Bile acid
AN27039_0952	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN27039_0953	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN27039_0954	COG1780	Probably involved in ribonucleotide reductase function
AN27039_0963	COG1760	l-serine dehydratase
AN27039_0965	COG1733	regulation of RNA biosynthetic process
AN27039_0967	COG0351	phosphomethylpyrimidine kinase
AN27039_0969	COG1121	(ABC) transporter
AN27039_0970	COG0305	Participates in initiation and elongation during chromosome replication
AN27039_0973	COG0359	binds to the 23S rRNA
AN27039_0974	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AN27039_0976	COG0360	Binds together with S18 to 16S ribosomal RNA
AN27039_0977	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN27039_0982	COG3764	Sortase (surface protein transpeptidase)
AN27039_0995	COG1476	TRANSCRIPTIONal
AN27039_0998	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN27039_0999	COG0187	DNA topoisomerase II activity
AN27039_1000	COG0187	DNA topoisomerase II activity
AN27039_1001	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AN27039_1002	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN27039_1003	COG0592	DNA-directed DNA polymerase activity
AN27039_1004	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN27039_1005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN27039_1006	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AN27039_1007	COG0594	ribonuclease P activity
AN27039_1008	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AN27039_1009	COG0706	membrane insertase activity
AN27039_1011	COG0357	Ribosomal RNA small subunit methyltransferase G
AN27039_1013	COG1192	Involved in chromosome partitioning
AN27039_1015	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN27039_1016	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN27039_1017	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN27039_1018	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN27039_1020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AN27039_1021	COG3118	belongs to the thioredoxin family
AN27039_1025	COG0728	peptidoglycan biosynthetic process
AN27039_1030	COG0617	tRNA 3'-terminal CCA addition
AN27039_1033	COG0673	inositol 2-dehydrogenase activity
AN27039_1034	COG3345	alpha-galactosidase
AN27039_1047	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AN27039_1048	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN27039_1050	COG0515	serine threonine protein kinase
AN27039_1050	COG2815	serine threonine protein kinase
AN27039_1051	COG0515	serine threonine protein kinase
AN27039_1052	COG0515	serine threonine protein kinase
AN27039_1053	COG0768	penicillin binding
AN27039_1055	COG0772	Belongs to the SEDS family
AN27039_1057	COG1716	ATPase activity
AN27039_1059	COG1716	ATPase activity
AN27039_1063	COG1966	Carbon starvation protein
AN27039_1064	COG2985	domain, Protein
AN27039_1064	COG0569	domain protein
AN27039_1065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AN27039_1067	COG0789	Transcriptional regulator
AN27039_1071	COG2409	Drug exporters of the RND superfamily
AN27039_1073	COG1854	S-ribosylhomocysteine lyase activity
AN27039_1074	COG1854	S-ribosylhomocysteine lyase activity
AN27039_1076	COG0628	permease
AN27039_1078	COG1940	carbohydrate kinase activity
AN27039_1079	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN27039_1079	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN27039_1080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN27039_1081	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN27039_1086	COG1113	amino acid transport
AN27039_1087	COG1113	amino acid transport
AN27039_1088	COG0483	inositol monophosphate 1-phosphatase activity
AN27039_1089	COG0477	Major facilitator Superfamily
AN27039_1094	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN27039_1104	COG1131	(ABC) transporter
AN27039_1121	COG4585	Histidine kinase
AN27039_1122	COG2197	response regulator
AN27039_1123	COG2197	response regulator
AN27039_1136	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AN27039_1137	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AN27039_1138	COG2181	nitrate reductase activity
AN27039_1138	COG0247	lactate metabolic process
AN27039_1149	COG3842	ATPase activity
AN27039_1151	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AN27039_1151	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AN27039_1164	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AN27039_1186	COG0778	Nitroreductase
AN27039_1194	COG2197	response regulator
AN27039_1201	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_1202	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AN27039_1204	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN27039_1207	COG0443	Heat shock 70 kDa protein
AN27039_1208	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN27039_1209	COG0484	heat shock protein binding
AN27039_1210	COG0789	Transcriptional regulator
AN27039_1215	COG2205	protein histidine kinase activity
AN27039_1216	COG0745	RESPONSE REGULATOR receiver
AN27039_1220	COG0577	efflux transmembrane transporter activity
AN27039_1220	COG1136	(ABC) transporter
AN27039_1223	COG3655	Transcriptional regulator
AN27039_1229	COG0542	response to heat
AN27039_1230	COG0542	response to heat
AN27039_1231	COG0542	response to heat
AN27039_1237	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN27039_1238	COG1609	Transcriptional regulator
AN27039_1239	COG1621	beta-fructofuranosidase activity
AN27039_1247	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN27039_1248	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN27039_1248	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN27039_1249	COG3715	PTS system
AN27039_1250	COG3716	PTS system mannose fructose sorbose family IID component
AN27039_1251	COG3716	PTS system mannose fructose sorbose family IID component
AN27039_1255	COG0561	phosphatase activity
AN27039_1259	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN27039_1263	COG1674	ftsk spoiiie
AN27039_1264	COG1674	ftsk spoiiie
AN27039_1265	COG1674	ftsk spoiiie
AN27039_1275	COG3842	ATPase activity
AN27039_1279	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN27039_1280	COG0215	cysteine-tRNA ligase activity
AN27039_1281	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AN27039_1282	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AN27039_1284	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AN27039_1287	COG0459	protein refolding
AN27039_1290	COG2205	protein histidine kinase activity
AN27039_1292	COG0745	RESPONSE REGULATOR receiver
AN27039_1294	COG1842	Phage shock protein A
AN27039_1297	COG0519	Catalyzes the synthesis of GMP from XMP
AN27039_1308	COG0789	Transcriptional regulator
AN27039_1313	COG1201	RNA secondary structure unwinding
AN27039_1314	COG1201	RNA secondary structure unwinding
AN27039_1315	COG1201	RNA secondary structure unwinding
AN27039_1317	COG1201	RNA secondary structure unwinding
AN27039_1318	COG2252	PERMEase
AN27039_1319	COG2252	PERMEase
AN27039_1320	COG2252	PERMEase
AN27039_1329	COG1388	LysM domain
AN27039_1329	COG3103	Sh3 type 3 domain protein
AN27039_1329	COG0791	NLP P60 protein
AN27039_1333	COG1970	mechanosensitive ion channel activity
AN27039_1334	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AN27039_1340	COG1297	OPT oligopeptide transporter protein
AN27039_1344	COG0697	spore germination
AN27039_1351	COG1335	isochorismatase
AN27039_1353	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN27039_1354	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN27039_1359	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN27039_1360	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AN27039_1361	COG0488	(ABC) transporter
AN27039_1362	COG0488	(ABC) transporter
AN27039_1379	COG0714	Associated with various cellular activities
AN27039_1385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AN27039_1385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AN27039_1386	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AN27039_1409	COG1309	transcriptional regulator
AN27039_1411	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN27039_1422	COG1136	(ABC) transporter
AN27039_1425	COG0148	phosphopyruvate hydratase activity
AN27039_1426	COG0148	phosphopyruvate hydratase activity
AN27039_1436	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN27039_1437	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN27039_1438	COG2197	response regulator
AN27039_1439	COG4585	Histidine kinase
AN27039_1447	COG0129	dihydroxy-acid dehydratase activity
AN27039_1449	COG0444	Belongs to the ABC transporter superfamily
AN27039_1451	COG1124	(ABC) transporter
AN27039_1455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN27039_1456	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN27039_1457	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN27039_1463	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN27039_1467	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN27039_1468	COG0513	Belongs to the DEAD box helicase family
AN27039_1474	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AN27039_1481	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN27039_1482	COG0745	RESPONSE REGULATOR receiver
AN27039_1484	COG3485	protocatechuate 3,4-dioxygenase
AN27039_1485	COG0354	folic acid binding
AN27039_1487	COG1490	D-aminoacyl-tRNA deacylase activity
AN27039_1492	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN27039_1494	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AN27039_1494	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AN27039_1513	COG0745	RESPONSE REGULATOR receiver
AN27039_1514	COG2205	protein histidine kinase activity
AN27039_1515	COG2132	Multicopper oxidase
AN27039_1516	COG2132	Multicopper oxidase
AN27039_1529	COG0542	response to heat
AN27039_1532	COG0438	transferase activity, transferring glycosyl groups
AN27039_1532	COG0297	glycogen (starch) synthase activity
AN27039_1535	COG2211	Major facilitator Superfamily
AN27039_1538	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN27039_1538	COG0574	Belongs to the PEP-utilizing enzyme family
AN27039_1540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AN27039_1547	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN27039_1547	COG0596	Alpha beta hydrolase
AN27039_1551	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN27039_1552	COG0698	ribose 5-phosphate isomerase
AN27039_1554	COG0698	ribose 5-phosphate isomerase
AN27039_1555	COG2814	Major facilitator Superfamily
AN27039_1576	COG0546	phosphoglycolate phosphatase activity
AN27039_1577	COG1362	aminopeptidase activity
AN27039_1578	COG0604	alcohol dehydrogenase
AN27039_1579	COG1733	regulation of RNA biosynthetic process
AN27039_1580	COG1902	pentaerythritol trinitrate reductase activity
AN27039_1583	COG2267	carboxylic ester hydrolase activity
AN27039_1585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN27039_1587	COG0601	transmembrane transport
AN27039_1588	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN27039_1589	COG4172	Belongs to the ABC transporter superfamily
AN27039_1616	COG1053	succinate dehydrogenase
AN27039_1619	COG2171	N-acyltransferase activity
AN27039_1620	COG0406	alpha-ribazole phosphatase activity
AN27039_1626	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN27039_1627	COG1397	ADP-ribosylglycohydrolase
AN27039_1632	COG3477	response to acidic pH
AN27039_1637	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AN27039_1638	COG2197	response regulator
AN27039_1642	COG2235	arginine
AN27039_1643	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AN27039_1646	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN27039_1648	COG1175	transmembrane transport
AN27039_1651	COG5426	von Willebrand factor, type A
AN27039_1654	COG1940	carbohydrate kinase activity
AN27039_1656	COG4176	ABC-type proline glycine betaine transport system permease component
AN27039_1660	COG4948	Mandelate Racemase Muconate Lactonizing
AN27039_1661	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AN27039_1662	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AN27039_1664	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN27039_1667	COG2226	methyltransferase
AN27039_1668	COG0644	oxidoreductase
AN27039_1670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN27039_1671	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN27039_1672	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN27039_1673	COG0649	NAD binding
AN27039_1676	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AN27039_1677	COG1034	ATP synthesis coupled electron transport
AN27039_1678	COG1034	ATP synthesis coupled electron transport
AN27039_1679	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AN27039_1680	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AN27039_1683	COG0713	ATP synthesis coupled electron transport
AN27039_1685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN27039_1688	COG1007	ATP synthesis coupled electron transport
AN27039_1696	COG0501	Belongs to the peptidase M48B family
AN27039_1700	COG2197	response regulator
AN27039_1701	COG1666	GTP binding
AN27039_1702	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN27039_1705	COG0424	maF-like protein
AN27039_1708	COG0745	RESPONSE REGULATOR receiver
AN27039_1709	COG5002	protein histidine kinase activity
AN27039_1717	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN27039_1718	COG1316	TRANSCRIPTIONal
AN27039_1725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN27039_1727	COG0673	inositol 2-dehydrogenase activity
AN27039_1740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AN27039_1758	COG0463	Glycosyl transferase, family 2
AN27039_1773	COG0463	Glycosyl transferase, family 2
AN27039_1773	COG1216	Glycosyl transferase, family 2
AN27039_1775	COG0438	transferase activity, transferring glycosyl groups
AN27039_1777	COG1091	dTDP-4-dehydrorhamnose reductase activity
AN27039_1781	COG1482	cell wall glycoprotein biosynthetic process
AN27039_1793	COG2835	tetraacyldisaccharide 4'-kinase activity
AN27039_1797	COG0714	Associated with various cellular activities
AN27039_1804	COG0745	RESPONSE REGULATOR receiver
AN27039_1805	COG5000	phosphorelay sensor kinase activity
AN27039_1805	COG5002	protein histidine kinase activity
AN27039_1806	COG5401	PFAM Sporulation and spore germination
AN27039_1807	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN27039_1809	COG0653	protein targeting
AN27039_1810	COG0653	protein targeting
AN27039_1818	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AN27039_1819	COG0222	ribosome binding
AN27039_1820	COG0085	RNA polymerase activity
AN27039_1821	COG0085	RNA polymerase activity
AN27039_1822	COG0085	RNA polymerase activity
AN27039_1823	COG0085	RNA polymerase activity
AN27039_1824	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AN27039_1828	COG1874	Beta-galactosidase
AN27039_1858	COG0419	ATPase involved in DNA repair
AN27039_1864	COG1968	undecaprenyl-diphosphatase activity
AN27039_1866	COG0483	inositol monophosphate 1-phosphatase activity
AN27039_1868	COG2249	NAD(P)H dehydrogenase (quinone) activity
AN27039_1869	COG0456	acetyltransferase
AN27039_1870	COG2249	NAD(P)H dehydrogenase (quinone) activity
AN27039_1872	COG1120	ATPase activity
AN27039_1874	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_1877	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_1885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AN27039_1894	COG1140	nitrate reductase beta subunit
AN27039_1895	COG1140	nitrate reductase beta subunit
AN27039_1896	COG1140	nitrate reductase beta subunit
AN27039_1907	COG0315	cyclic pyranopterin monophosphate synthase activity
AN27039_1909	COG0314	molybdopterin synthase activity
AN27039_1911	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN27039_1919	COG1162	GTPase activity
AN27039_1920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN27039_1921	COG2838	Isocitrate dehydrogenase
AN27039_1922	COG2838	Isocitrate dehydrogenase
AN27039_1924	COG1595	DNA-templated transcription, initiation
AN27039_1928	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN27039_1928	COG0567	Dehydrogenase, E1 component
AN27039_1933	COG1253	flavin adenine dinucleotide binding
AN27039_1936	COG0739	heme binding
AN27039_1939	COG0018	arginyl-trna synthetase
AN27039_1940	COG0019	diaminopimelate decarboxylase activity
AN27039_1943	COG0460	homoserine dehydrogenase
AN27039_1944	COG0083	homoserine kinase activity
AN27039_1945	COG0083	homoserine kinase activity
AN27039_1946	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN27039_1951	COG0254	rRNA binding
AN27039_1952	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN27039_1953	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN27039_1955	COG2890	protein-(glutamine-N5) methyltransferase activity
AN27039_1956	COG1846	Transcriptional regulator
AN27039_1957	COG0604	alcohol dehydrogenase
AN27039_1959	COG0693	protein deglycase activity
AN27039_1965	COG0110	maltose O-acetyltransferase activity
AN27039_1966	COG1501	Belongs to the glycosyl hydrolase 31 family
AN27039_1972	COG0205	6-phosphofructokinase activity
AN27039_1975	COG0045	succinate-CoA ligase (ADP-forming) activity
AN27039_1983	COG1132	(ABC) transporter
AN27039_1987	COG0039	L-malate dehydrogenase activity
AN27039_1990	COG1175	transmembrane transport
AN27039_1991	COG0395	ABC-type sugar transport system, permease component
AN27039_1998	COG0058	SHG alpha-glucan phosphorylase activity
AN27039_1999	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AN27039_2000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AN27039_2001	COG3281	Trehalose synthase
AN27039_2004	COG0366	Alpha amylase catalytic
AN27039_2005	COG0366	Alpha amylase catalytic
AN27039_2006	COG0180	Tryptophanyl-tRNA synthetase
AN27039_2008	COG1523	belongs to the glycosyl hydrolase 13 family
AN27039_2010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AN27039_2011	COG0482	sulfurtransferase activity
AN27039_2012	COG0482	sulfurtransferase activity
AN27039_2018	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN27039_2024	COG3480	Lon protease (S16) C-terminal proteolytic domain
AN27039_2027	COG1615	UPF0182 protein
AN27039_2028	COG1615	UPF0182 protein
AN27039_2031	COG2326	polyphosphate kinase activity
AN27039_2049	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN27039_2050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN27039_2055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN27039_2057	COG1263	PTS System
AN27039_2057	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN27039_2062	COG2190	(PTS) system
AN27039_2063	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN27039_2063	COG1263	PTS System
AN27039_2064	COG2188	Transcriptional regulator
AN27039_2065	COG2190	(PTS) system
AN27039_2065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN27039_2065	COG1263	PTS System
AN27039_2066	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN27039_2066	COG1263	PTS System
AN27039_2072	COG3590	peptidase
AN27039_2073	COG3590	peptidase
AN27039_2079	COG1045	serine acetyltransferase
AN27039_2081	COG1739	Uncharacterized protein family UPF0029
AN27039_2083	COG0544	peptidyl-prolyl cis-trans isomerase activity
AN27039_2087	COG0740	serine-type endopeptidase activity
AN27039_2088	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AN27039_2089	COG1605	Chorismate mutase
AN27039_2089	COG0287	Prephenate dehydrogenase
AN27039_2097	COG0366	Alpha amylase catalytic
AN27039_2098	COG0454	-acetyltransferase
AN27039_2100	COG0525	valine-tRNA ligase activity
AN27039_2102	COG1222	aaa ATPase
AN27039_2103	COG4122	O-methyltransferase activity
AN27039_2105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AN27039_2107	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AN27039_2109	COG1122	ATPase activity
AN27039_2120	COG0730	response to heat
AN27039_2121	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AN27039_2121	COG1648	precorrin-2 dehydrogenase activity
AN27039_2122	COG0529	Catalyzes the synthesis of activated sulfate
AN27039_2122	COG2895	sulfate adenylyltransferase (ATP) activity
AN27039_2126	COG0175	sulfate reduction
AN27039_2127	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN27039_2128	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN27039_2129	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AN27039_2130	COG2056	Na+-H+ antiporter family
AN27039_2131	COG4221	oxidoreductase activity
AN27039_2135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN27039_2140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AN27039_2144	COG1215	transferase activity, transferring glycosyl groups
AN27039_2154	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AN27039_2155	COG0285	dihydrofolate synthase activity
AN27039_2156	COG1461	Dihydroxyacetone kinase
AN27039_2157	COG0105	UTP biosynthetic process
AN27039_2160	COG4152	abc transporter atp-binding protein
AN27039_2161	COG1196	nuclear chromosome segregation
AN27039_2165	COG2197	response regulator
AN27039_2166	COG4585	Histidine kinase
AN27039_2167	COG0842	Transport permease protein
AN27039_2168	COG1131	(ABC) transporter
AN27039_2171	COG2197	response regulator
AN27039_2172	COG4585	Histidine kinase
AN27039_2177	COG1837	Belongs to the UPF0109 family
AN27039_2178	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN27039_2179	COG0336	Belongs to the RNA methyltransferase TrmD family
AN27039_2181	COG0681	Belongs to the peptidase S26 family
AN27039_2182	COG0335	large ribosomal subunit rRNA binding
AN27039_2184	COG0681	Belongs to the peptidase S26 family
AN27039_2185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN27039_2187	COG0792	nuclease activity
AN27039_2197	COG4974	Belongs to the 'phage' integrase family
AN27039_2201	COG0052	Belongs to the universal ribosomal protein uS2 family
AN27039_2202	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AN27039_2204	COG0233	cytoplasmic translational termination
AN27039_2206	COG0575	Belongs to the CDS family
AN27039_2208	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN27039_2209	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN27039_2211	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AN27039_2212	COG0750	zinc metalloprotease
AN27039_2213	COG0750	zinc metalloprotease
AN27039_2214	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AN27039_2216	COG0456	acetyltransferase
AN27039_2223	COG0442	prolyl-tRNA aminoacylation
AN27039_2224	COG0442	prolyl-tRNA aminoacylation
AN27039_2231	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN27039_2232	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN27039_2233	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AN27039_2237	COG0330	HflC and HflK could
AN27039_2239	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AN27039_2240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN27039_2242	COG1136	(ABC) transporter
AN27039_2242	COG0577	efflux transmembrane transporter activity
AN27039_2249	COG1454	alcohol dehydrogenase
AN27039_2250	COG1185	polyribonucleotide nucleotidyltransferase activity
AN27039_2251	COG1185	polyribonucleotide nucleotidyltransferase activity
AN27039_2252	COG0612	Peptidase, M16
AN27039_2253	COG0300	oxidoreductase activity
AN27039_2254	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN27039_2255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN27039_2259	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN27039_2260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN27039_2261	COG0318	PFAM AMP-dependent synthetase and ligase
AN27039_2262	COG0318	PFAM AMP-dependent synthetase and ligase
AN27039_2263	COG0318	PFAM AMP-dependent synthetase and ligase
AN27039_2264	COG1021	2,3-dihydroxybenzoate-AMP ligase
AN27039_2273	COG2001	Belongs to the MraZ family
AN27039_2275	COG0275	rRNA processing
AN27039_2278	COG0768	penicillin binding
AN27039_2279	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN27039_2282	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN27039_2283	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN27039_2284	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN27039_2285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN27039_2287	COG0772	Belongs to the SEDS family
AN27039_2289	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN27039_2290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN27039_2291	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN27039_2294	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN27039_2296	COG1799	cell septum assembly
AN27039_2299	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AN27039_2302	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AN27039_2304	COG0587	DNA-directed DNA polymerase activity
AN27039_2306	COG0587	DNA-directed DNA polymerase activity
AN27039_2308	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN27039_2309	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN27039_2310	COG2501	S4 domain
AN27039_2316	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN27039_2317	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN27039_2318	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN27039_2320	COG1215	transferase activity, transferring glycosyl groups
AN27039_2322	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AN27039_2323	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AN27039_2326	COG0514	ATP-dependent DNA helicase (RecQ)
AN27039_2331	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN27039_2332	COG0131	Imidazoleglycerol-phosphate dehydratase
AN27039_2336	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN27039_2337	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AN27039_2343	COG1131	(ABC) transporter
AN27039_2348	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AN27039_2349	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AN27039_2350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN27039_2354	COG1126	abc transporter atp-binding protein
AN27039_2357	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN27039_2358	COG0765	amino acid transport
AN27039_2359	COG0765	amino acid transport
AN27039_2362	COG1131	(ABC) transporter
AN27039_2364	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AN27039_2367	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AN27039_2369	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN27039_2370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AN27039_2371	COG1438	arginine binding
AN27039_2373	COG0137	argininosuccinate synthase activity
AN27039_2374	COG2116	formate transmembrane transporter activity
AN27039_2375	COG0165	Argininosuccinate lyase
AN27039_2376	COG2094	Belongs to the DNA glycosylase MPG family
AN27039_2381	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN27039_2383	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN27039_2385	COG0647	UMP catabolic process
AN27039_2390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN27039_2391	COG0497	DNA recombination
AN27039_2404	COG1175	transmembrane transport
AN27039_2405	COG0395	ABC-type sugar transport system, permease component
AN27039_2406	COG1621	beta-fructofuranosidase activity
AN27039_2410	COG0719	Fe-S assembly protein
AN27039_2411	COG0396	ATPase activity
AN27039_2413	COG0822	iron-sulfur transferase activity
AN27039_2414	COG2151	metal-sulfur cluster biosynthetic enzyme
AN27039_2416	COG1309	transcriptional regulator
AN27039_2420	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AN27039_2422	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AN27039_2423	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AN27039_2427	COG0167	dihydroorotate dehydrogenase activity
AN27039_2428	COG0167	dihydroorotate dehydrogenase activity
AN27039_2435	COG3833	ABC-type maltose transport systems, permease component
AN27039_2436	COG1175	transmembrane transport
AN27039_2447	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AN27039_2449	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AN27039_2451	COG1027	Aspartate ammonia-lyase
AN27039_2453	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AN27039_2454	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AN27039_2475	COG3022	response to hydroperoxide
AN27039_2479	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AN27039_2480	COG0174	glutamine synthetase
AN27039_2483	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AN27039_2484	COG0406	alpha-ribazole phosphatase activity
AN27039_2486	COG0765	amino acid transport
AN27039_2492	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN27039_2493	COG0321	lipoyl(octanoyl) transferase activity
AN27039_2502	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN27039_2503	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN27039_2504	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN27039_2505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN27039_2506	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN27039_2507	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN27039_2510	COG0038	chloride channel
AN27039_2511	COG1073	alpha beta
AN27039_2512	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN27039_2513	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN27039_2514	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN27039_2515	COG1882	Formate acetyltransferase
AN27039_2529	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AN27039_2535	COG0438	transferase activity, transferring glycosyl groups
AN27039_2540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AN27039_2541	COG1051	belongs to the nudix hydrolase family
AN27039_2542	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AN27039_2543	COG0217	transcriptional regulatory protein
AN27039_2544	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AN27039_2545	COG0632	four-way junction helicase activity
AN27039_2546	COG2255	four-way junction helicase activity
AN27039_2548	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN27039_2550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN27039_2551	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN27039_2552	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN27039_2553	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN27039_2554	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN27039_2556	COG0789	Transcriptional regulator
AN27039_2558	COG1196	nuclear chromosome segregation
AN27039_2562	COG0124	histidyl-tRNA synthetase
AN27039_2565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN27039_2572	COG0513	Belongs to the DEAD box helicase family
AN27039_2574	COG1116	anion transmembrane transporter activity
AN27039_2574	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN27039_2578	COG2382	esterase
AN27039_2583	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AN27039_2590	COG0009	L-threonylcarbamoyladenylate synthase
AN27039_2594	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AN27039_2595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN27039_2596	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN27039_2597	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN27039_2598	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN27039_2601	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AN27039_2603	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AN27039_2604	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN27039_2605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN27039_2611	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AN27039_2612	COG0540	Belongs to the ATCase OTCase family
AN27039_2613	COG0540	Belongs to the ATCase OTCase family
AN27039_2614	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN27039_2616	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AN27039_2617	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AN27039_2618	COG0284	orotidine-5'-phosphate decarboxylase activity
AN27039_2620	COG0194	GDP metabolic process
AN27039_2621	COG1758	RNA polymerase activity
AN27039_2623	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN27039_2625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AN27039_2627	COG0477	Major facilitator Superfamily
AN27039_2629	COG1834	amidinotransferase
AN27039_2630	COG0549	Belongs to the carbamate kinase family
AN27039_2631	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AN27039_2635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AN27039_2637	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN27039_2638	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN27039_2640	COG4770	biotin carboxylase activity
AN27039_2641	COG4770	biotin carboxylase activity
AN27039_2642	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN27039_2644	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AN27039_2645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AN27039_2647	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN27039_2648	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN27039_2649	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN27039_2650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN27039_2651	COG0140	phosphoribosyl-ATP diphosphatase activity
AN27039_2655	COG1131	(ABC) transporter
AN27039_2657	COG2197	response regulator
AN27039_2658	COG4585	Histidine kinase
AN27039_2664	COG0805	protein transport
AN27039_2666	COG4581	dead DEAH box helicase
AN27039_2670	COG2354	Protein conserved in bacteria
AN27039_2671	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AN27039_2672	COG1216	Glycosyl transferase, family 2
AN27039_2675	COG0205	6-phosphofructokinase activity
AN27039_2676	COG0205	6-phosphofructokinase activity
AN27039_2677	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AN27039_2679	COG0577	efflux transmembrane transporter activity
AN27039_2680	COG1136	(ABC) transporter
AN27039_2683	COG1609	Transcriptional regulator
AN27039_2685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN27039_2685	COG2190	(PTS) system
AN27039_2685	COG1263	PTS System
AN27039_2686	COG2190	(PTS) system
AN27039_2686	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN27039_2686	COG1263	PTS System
AN27039_2687	COG1621	beta-fructofuranosidase activity
AN27039_2689	COG1621	beta-fructofuranosidase activity
AN27039_2695	COG0443	Heat shock 70 kDa protein
AN27039_2697	COG0443	Heat shock 70 kDa protein
AN27039_2700	COG0667	Aldo Keto reductase
AN27039_2704	COG1716	ATPase activity
AN27039_2707	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AN27039_2712	COG0363	glucosamine-6-phosphate deaminase activity
AN27039_2720	COG0166	Belongs to the GPI family
AN27039_2721	COG0166	Belongs to the GPI family
AN27039_2724	COG1160	GTP binding
AN27039_2725	COG0287	Prephenate dehydrogenase
AN27039_2728	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AN27039_2730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AN27039_2733	COG4974	Belongs to the 'phage' integrase family
AN27039_2734	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN27039_2735	COG0149	triose-phosphate isomerase activity
AN27039_2736	COG0126	phosphoglycerate kinase activity
AN27039_2737	COG0126	phosphoglycerate kinase activity
AN27039_2738	COG0126	phosphoglycerate kinase activity
AN27039_2740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN27039_2741	COG1481	regulation of sporulation
AN27039_2743	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AN27039_2744	COG1660	Displays ATPase and GTPase activities
AN27039_2745	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AN27039_2747	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AN27039_2750	COG3585	molybdate ion transport
AN27039_2751	COG0322	excinuclease ABC activity
AN27039_2752	COG0322	excinuclease ABC activity
AN27039_2753	COG0322	excinuclease ABC activity
AN27039_2765	COG0861	Integral membrane protein TerC family
AN27039_2767	COG0556	nucleotide-excision repair
AN27039_2768	COG0556	nucleotide-excision repair
AN27039_2769	COG0556	nucleotide-excision repair
AN27039_2770	COG0237	dephospho-CoA kinase activity
AN27039_2772	COG0539	negative regulation of cytoplasmic translation
AN27039_2775	COG2050	protein possibly involved in aromatic compounds catabolism
AN27039_2779	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AN27039_2780	COG0134	indole-3-glycerol-phosphate synthase activity
AN27039_2783	COG0107	imidazoleglycerol-phosphate synthase activity
AN27039_2785	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AN27039_2786	COG1222	aaa ATPase
AN27039_2790	COG2837	iron assimilation
AN27039_2792	COG0517	IMP dehydrogenase activity
AN27039_2792	COG1994	Peptidase M50
AN27039_2794	COG2391	methyltransferase activity
AN27039_2795	COG0425	Belongs to the sulfur carrier protein TusA family
AN27039_2796	COG0667	Aldo Keto reductase
AN27039_2798	COG4605	iron ion homeostasis
AN27039_2799	COG4605	iron ion homeostasis
AN27039_2800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN27039_2801	COG4607	ABC-type enterochelin transport system periplasmic component
AN27039_2804	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN27039_2805	COG0339	signal peptide processing
AN27039_2809	COG0477	Major facilitator Superfamily
AN27039_2821	COG0587	DNA-directed DNA polymerase activity
AN27039_2823	COG0587	DNA-directed DNA polymerase activity
AN27039_2824	COG0587	DNA-directed DNA polymerase activity
AN27039_2825	COG0587	DNA-directed DNA polymerase activity
AN27039_2830	COG1435	thymidine kinase activity
AN27039_2831	COG0671	phosphoesterase, PA-phosphatase related
AN27039_2836	COG1881	PFAM PEBP family protein
AN27039_2837	COG4221	oxidoreductase activity
AN27039_2838	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN27039_2839	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN27039_2842	COG4555	ABC transporter
AN27039_2845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN27039_2846	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN27039_2851	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AN27039_2852	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AN27039_2853	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN27039_2855	COG0531	amino acid
AN27039_2856	COG0569	domain protein
AN27039_2865	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN27039_2868	COG0187	DNA topoisomerase II activity
AN27039_2873	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN27039_2877	COG0515	serine threonine protein kinase
AN27039_2877	COG2815	serine threonine protein kinase
AN27039_2879	COG2815	serine threonine protein kinase
AN27039_2879	COG0515	serine threonine protein kinase
AN27039_2880	COG0515	serine threonine protein kinase
AN27039_2880	COG2815	serine threonine protein kinase
AN27039_2881	COG0515	serine threonine protein kinase
AN27039_2882	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AN27039_2884	COG0205	6-phosphofructokinase activity
AN27039_2889	COG0545	Peptidyl-prolyl cis-trans isomerase
AN27039_2894	COG0488	(ABC) transporter
AN27039_2901	COG1121	(ABC) transporter
AN27039_2904	COG0297	glycogen (starch) synthase activity
AN27039_2905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AN27039_2906	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AN27039_2907	COG0560	Phosphoserine phosphatase
AN27039_2908	COG0560	Phosphoserine phosphatase
AN27039_2908	COG3830	Belongs to the UPF0237 family
AN27039_2911	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN27039_2914	COG0423	glycine-tRNA ligase activity
AN27039_2916	COG1121	(ABC) transporter
AN27039_2917	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN27039_2919	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN27039_2920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN27039_2921	COG1381	Involved in DNA repair and RecF pathway recombination
AN27039_2922	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN27039_2923	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN27039_2924	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN27039_2925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN27039_2926	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN27039_2930	COG1476	TRANSCRIPTIONal
AN27039_2931	COG2337	Toxic component of a toxin-antitoxin (TA) module
AN27039_2934	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AN27039_2934	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AN27039_2934	COG0506	proline dehydrogenase activity
AN27039_2936	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN27039_2942	COG0842	Transport permease protein
AN27039_2946	COG0484	heat shock protein binding
AN27039_2947	COG1420	regulation of RNA biosynthetic process
AN27039_2950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AN27039_2954	COG2807	transmembrane transport
AN27039_2955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN27039_2957	COG0481	GTPase activity
AN27039_2958	COG0481	GTPase activity
AN27039_2960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AN27039_2961	COG0512	Glutamine amidotransferase of anthranilate synthase
AN27039_2962	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AN27039_2964	COG0159	tryptophan synthase activity
AN27039_2971	COG0268	Binds directly to 16S ribosomal RNA
AN27039_2972	COG4868	Belongs to the UPF0371 family
AN27039_2973	COG4868	Belongs to the UPF0371 family
AN27039_2977	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN27039_2977	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN27039_2978	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AN27039_2983	COG0438	transferase activity, transferring glycosyl groups
AN27039_2984	COG0438	transferase activity, transferring glycosyl groups
AN27039_2986	COG0433	COG0433 Predicted ATPase
AN27039_2987	COG0495	leucyl-tRNA aminoacylation
AN27039_2990	COG0537	adenosine 5'-monophosphoramidase activity
AN27039_2998	COG0733	neurotransmitter:sodium symporter activity
AN27039_2999	COG0813	purine-nucleoside phosphorylase activity
AN27039_3002	COG2095	MarC family integral membrane protein
AN27039_3003	COG0406	alpha-ribazole phosphatase activity
AN27039_3004	COG0799	negative regulation of ribosome biogenesis
AN27039_3007	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AN27039_3011	COG1349	DNA-binding transcription factor activity
AN27039_3012	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN27039_3015	COG1132	(ABC) transporter
AN27039_3018	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AN27039_3019	COG2205	protein histidine kinase activity
AN27039_3020	COG0745	RESPONSE REGULATOR receiver
AN27039_3021	COG0745	RESPONSE REGULATOR receiver
AN27039_3023	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AN27039_3024	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AN27039_3025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN27039_3026	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AN27039_3027	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN27039_3029	COG1530	ribonuclease E activity
AN27039_3032	COG1271	oxidase subunit
AN27039_3034	COG1294	oxidase, subunit
AN27039_3035	COG4988	ABC transporter
AN27039_3036	COG2274	protein secretion by the type I secretion system
AN27039_3037	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AN27039_3038	COG1132	(ABC) transporter
AN27039_3042	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AN27039_3043	COG0571	ribonuclease III activity
AN27039_3046	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AN27039_3047	COG1609	Transcriptional regulator
AN27039_3048	COG0738	Major facilitator superfamily
AN27039_3049	COG4154	Belongs to the RbsD FucU family
AN27039_3050	COG1070	Carbohydrate kinase
AN27039_3052	COG0235	Class ii aldolase
AN27039_3054	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AN27039_3058	COG1461	Dihydroxyacetone kinase
AN27039_3059	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN27039_3061	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN27039_3062	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN27039_3064	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN27039_3065	COG0066	3-isopropylmalate dehydratase activity
AN27039_3070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN27039_3072	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN27039_3076	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AN27039_3079	COG2813	Specifically methylates the guanine in position
AN27039_3083	COG1114	Component of the transport system for branched-chain amino acids
AN27039_3085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AN27039_3089	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN27039_3090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN27039_3092	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN27039_3092	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN27039_3093	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN27039_3093	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN27039_3094	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN27039_3094	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN27039_3095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN27039_3096	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN27039_3097	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN27039_3098	COG0509	glycine decarboxylation via glycine cleavage system
AN27039_3100	COG1846	Transcriptional regulator
AN27039_3100	COG1940	carbohydrate kinase activity
AN27039_3101	COG1940	carbohydrate kinase activity
AN27039_3103	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AN27039_3104	COG2137	regulation of response to DNA damage stimulus
AN27039_3105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AN27039_3107	COG1396	sequence-specific DNA binding
AN27039_3108	COG1058	Belongs to the CinA family
AN27039_3108	COG1546	Belongs to the CinA family
AN27039_3110	COG2843	Capsule synthesis protein
AN27039_3111	COG1674	ftsk spoiiie
AN27039_3114	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN27039_3116	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AN27039_3119	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN27039_3120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN27039_3122	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN27039_3123	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN27039_3124	COG1115	amino acid carrier protein
AN27039_3125	COG1115	amino acid carrier protein
AN27039_3126	COG1115	amino acid carrier protein
AN27039_3127	COG1115	amino acid carrier protein
AN27039_3133	COG2040	homocysteine
AN27039_3134	COG0833	amino acid
AN27039_3135	COG3304	Inner membrane component domain
AN27039_3144	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AN27039_3145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AN27039_3148	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN27039_3149	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN27039_3151	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN27039_3157	COG0363	glucosamine-6-phosphate deaminase activity
AN27039_3162	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AN27039_3163	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AN27039_3164	COG1940	carbohydrate kinase activity
AN27039_3165	COG4608	Belongs to the ABC transporter superfamily
AN27039_3167	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN27039_3169	COG0601	transmembrane transport
AN27039_3170	COG0601	transmembrane transport
AN27039_3172	COG0747	negative chemotaxis
AN27039_3173	COG2188	Transcriptional regulator
AN27039_3181	COG2884	Cell division ATP-binding protein ftsE
AN27039_3191	COG1131	(ABC) transporter
AN27039_3191	COG1716	ATPase activity
AN27039_3191	COG0842	Transport permease protein
AN27039_3194	COG0515	serine threonine protein kinase
AN27039_3195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AN27039_3197	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AN27039_3199	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN27039_3203	COG1134	teichoic acid transport
AN27039_3205	COG0463	Glycosyl transferase, family 2
AN27039_3212	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AN27039_3216	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AN27039_3217	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AN27039_3218	COG0463	Glycosyl transferase, family 2
AN27039_3218	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AN27039_3219	COG1215	transferase activity, transferring glycosyl groups
AN27039_3220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AN27039_3222	COG1316	TRANSCRIPTIONal
AN27039_3223	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN27039_3226	COG0473	3-isopropylmalate dehydrogenase activity
AN27039_3227	COG1309	transcriptional regulator
AN27039_3229	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate