locus-tag	class	description
PGE45_00010	COG0357	Ribosomal RNA small subunit methyltransferase G
PGE45_00020	COG0706	membrane insertase activity
PGE45_00025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PGE45_00030	COG0594	ribonuclease P activity
PGE45_00035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PGE45_00040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PGE45_00045	COG0592	DNA-directed DNA polymerase activity
PGE45_00050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PGE45_00055	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
PGE45_00060	COG0187	DNA topoisomerase II activity
PGE45_00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PGE45_00100	COG1476	TRANSCRIPTIONal
PGE45_00175	COG3764	Sortase (surface protein transpeptidase)
PGE45_00190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PGE45_00195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PGE45_00200	COG0360	Binds together with S18 to 16S ribosomal RNA
PGE45_00210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PGE45_00215	COG0359	binds to the 23S rRNA
PGE45_00225	COG0534	Mate efflux family protein
PGE45_00230	COG0305	Participates in initiation and elongation during chromosome replication
PGE45_00240	COG1121	(ABC) transporter
PGE45_00250	COG0351	phosphomethylpyrimidine kinase
PGE45_00255	COG0702	epimerase
PGE45_00260	COG1733	regulation of RNA biosynthetic process
PGE45_00270	COG1760	l-serine dehydratase
PGE45_00310	COG1780	Probably involved in ribonucleotide reductase function
PGE45_00315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PGE45_00325	COG0385	Bile acid
PGE45_00330	COG1072	(Pantothenic acid kinase))
PGE45_00375	COG1609	Transcriptional regulator
PGE45_00385	COG2211	Major facilitator Superfamily
PGE45_00405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PGE45_00410	COG0561	phosphatase activity
PGE45_00415	COG1653	transport
PGE45_00460	COG0596	Alpha beta hydrolase
PGE45_00465	COG0626	cystathionine gamma-synthase activity
PGE45_00470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PGE45_00485	COG1937	Protein conserved in bacteria
PGE45_00495	COG2197	response regulator
PGE45_00540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PGE45_00585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PGE45_00610	COG2813	Specifically methylates the guanine in position
PGE45_00630	COG1950	PFAM Membrane protein of
PGE45_00635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PGE45_00735	COG0463	Glycosyl transferase, family 2
PGE45_00755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PGE45_00770	COG2011	ABC-type metal ion transport system permease component
PGE45_00775	COG1464	Belongs to the NlpA lipoprotein family
PGE45_00780	COG3311	Transcriptional regulator
PGE45_00790	COG1569	PIN domain
PGE45_00810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PGE45_00830	COG0577	efflux transmembrane transporter activity
PGE45_00830	COG1136	(ABC) transporter
PGE45_00840	COG4585	Histidine kinase
PGE45_00860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PGE45_00865	COG2197	response regulator
PGE45_00870	COG4585	Histidine kinase
PGE45_00880	COG0577	efflux transmembrane transporter activity
PGE45_00880	COG1136	(ABC) transporter
PGE45_00890	COG0656	L-ascorbic acid biosynthetic process
PGE45_00895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PGE45_00900	COG0590	tRNA wobble adenosine to inosine editing
PGE45_00900	COG0037	tRNA processing
PGE45_00915	COG1643	Atp-dependent helicase
PGE45_00980	COG2233	PERMEase
PGE45_01035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PGE45_01085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PGE45_01110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PGE45_01120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PGE45_01125	COG0113	porphobilinogen synthase activity
PGE45_01135	COG0181	hydroxymethylbilane synthase activity
PGE45_01145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PGE45_01150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PGE45_01155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PGE45_01160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PGE45_01160	COG3253	May function as heme-dependent peroxidase
PGE45_01180	COG0783	Belongs to the Dps family
PGE45_01205	COG2207	Transcriptional regulator
PGE45_01205	COG3708	Transcriptional regulator
PGE45_01230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PGE45_01230	COG1918	ferrous iron import across plasma membrane
PGE45_01245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PGE45_01245	COG1918	ferrous iron import across plasma membrane
PGE45_01265	COG1597	lipid kinase activity
PGE45_01290	COG1028	Short-chain dehydrogenase reductase Sdr
PGE45_01295	COG1408	metallophosphoesterase
PGE45_01300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PGE45_01325	COG1136	(ABC) transporter
PGE45_01335	COG2267	carboxylic ester hydrolase activity
PGE45_01340	COG3548	integral membrane protein
PGE45_01350	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PGE45_01400	COG0450	alkyl hydroperoxide reductase
PGE45_01405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PGE45_01435	COG2205	protein histidine kinase activity
PGE45_01440	COG0745	RESPONSE REGULATOR receiver
PGE45_01455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PGE45_01455	COG1754	DNA topoisomerase type I activity
PGE45_01465	COG0745	RESPONSE REGULATOR receiver
PGE45_01470	COG5002	protein histidine kinase activity
PGE45_01475	COG2885	chlorophyll binding
PGE45_01485	COG2188	Transcriptional regulator
PGE45_01510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PGE45_01515	COG0470	DNA polymerase III
PGE45_01540	COG0252	asparaginase activity
PGE45_01545	COG1113	amino acid transport
PGE45_01560	COG0588	phosphoglycerate mutase activity
PGE45_01570	COG5002	protein histidine kinase activity
PGE45_01575	COG0745	RESPONSE REGULATOR receiver
PGE45_01585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PGE45_01615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PGE45_01630	COG1643	Atp-dependent helicase
PGE45_01650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PGE45_01655	COG2860	membrane
PGE45_01725	COG0714	Associated with various cellular activities
PGE45_01790	COG0717	Belongs to the dCTP deaminase family
PGE45_01800	COG2176	DNA-directed DNA polymerase activity
PGE45_01815	COG1028	Short-chain dehydrogenase reductase Sdr
PGE45_01820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PGE45_01825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PGE45_01830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PGE45_01835	COG0191	fructose-bisphosphate aldolase activity
PGE45_01865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PGE45_01900	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PGE45_01940	COG0151	Belongs to the GarS family
PGE45_01945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PGE45_01965	COG0047	phosphoribosylformylglycinamidine synthase activity
PGE45_02005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PGE45_02035	COG1090	epimerase
PGE45_02045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PGE45_02050	COG4085	toxin activity
PGE45_02050	COG1525	nuclease
PGE45_02050	COG0737	Belongs to the 5'-nucleotidase family
PGE45_02055	COG1349	DNA-binding transcription factor activity
PGE45_02065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PGE45_02065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PGE45_02065	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PGE45_02075	COG0557	exoribonuclease II activity
PGE45_02090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PGE45_02095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PGE45_02120	COG1132	(ABC) transporter
PGE45_02125	COG1132	(ABC) transporter
PGE45_02130	COG0577	efflux transmembrane transporter activity
PGE45_02135	COG1136	(ABC) transporter
PGE45_02145	COG1472	Belongs to the glycosyl hydrolase 3 family
PGE45_02185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PGE45_02205	COG1722	exodeoxyribonuclease VII activity
PGE45_02210	COG1570	exodeoxyribonuclease VII activity
PGE45_02215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PGE45_02220	COG0833	amino acid
PGE45_02235	COG1595	DNA-templated transcription, initiation
PGE45_02265	COG2261	transglycosylase associated protein
PGE45_02270	COG1322	Protein conserved in bacteria
PGE45_02280	COG0012	GTP binding
PGE45_02360	COG3549	Plasmid maintenance system killer
PGE45_02370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PGE45_02375	COG2873	o-acetylhomoserine
PGE45_02385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PGE45_02390	COG2027	D-alanyl-D-alanine carboxypeptidase
PGE45_02400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PGE45_02410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PGE45_02415	COG0302	gtp cyclohydrolase
PGE45_02430	COG2076	Multidrug Resistance protein
PGE45_02435	COG2826	transposase and inactivated derivatives, IS30 family
PGE45_02450	COG2197	response regulator
PGE45_02455	COG0577	efflux transmembrane transporter activity
PGE45_02455	COG1136	(ABC) transporter
PGE45_02460	COG1136	(ABC) transporter
PGE45_02465	COG1136	(ABC) transporter
PGE45_02465	COG0577	efflux transmembrane transporter activity
PGE45_02470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PGE45_02475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PGE45_02500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PGE45_02505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PGE45_02515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PGE45_02545	COG1136	(ABC) transporter
PGE45_02555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PGE45_02560	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PGE45_02565	COG1120	ATPase activity
PGE45_02570	COG4592	Periplasmic binding protein
PGE45_02575	COG3104	oligopeptide transport
PGE45_02580	COG3104	oligopeptide transport
PGE45_02595	COG1556	Lactate utilization protein
PGE45_02600	COG1139	Iron-sulfur cluster binding protein
PGE45_02605	COG0247	lactate metabolic process
PGE45_02610	COG1620	l-lactate permease
PGE45_02615	COG2217	Heavy metal translocating P-type atpase
PGE45_02620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PGE45_02625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PGE45_02630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PGE45_02640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PGE45_02675	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PGE45_02720	COG2376	Dihydroxyacetone kinase
PGE45_02725	COG1461	Dihydroxyacetone kinase
PGE45_02750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PGE45_02765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PGE45_02770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PGE45_02790	COG0436	Aminotransferase
PGE45_02800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PGE45_02805	COG0250	Participates in transcription elongation, termination and antitermination
PGE45_02815	COG0081	regulation of translation
PGE45_02840	COG2885	chlorophyll binding
PGE45_02880	COG2197	response regulator
PGE45_02885	COG3851	Histidine kinase
PGE45_02910	COG2894	cell division
PGE45_02935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PGE45_02940	COG0049	tRNA binding
PGE45_02945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PGE45_02950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PGE45_02970	COG0051	transcription antitermination factor activity, RNA binding
PGE45_02985	COG0089	rRNA binding
PGE45_02990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PGE45_02995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PGE45_03000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PGE45_03005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PGE45_03010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PGE45_03015	COG0255	Belongs to the universal ribosomal protein uL29 family
PGE45_03020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PGE45_03025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PGE45_03030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PGE45_03035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PGE45_03040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PGE45_03045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PGE45_03050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PGE45_03055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PGE45_03060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PGE45_03065	COG1841	ribosomal large subunit assembly
PGE45_03080	COG0563	adenylate kinase activity
PGE45_03085	COG0024	Methionine aminopeptidase
PGE45_03090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PGE45_03095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PGE45_03100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PGE45_03105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PGE45_03110	COG0202	RNA polymerase activity
PGE45_03125	COG1285	pathogenesis
PGE45_03130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PGE45_03135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PGE45_03145	COG0101	tRNA pseudouridine synthase activity
PGE45_03150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PGE45_03155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PGE45_03185	COG1395	domain, Protein
PGE45_03190	COG0596	Alpha beta hydrolase
PGE45_03195	COG1072	(Pantothenic acid kinase))
PGE45_03205	COG0736	holo-[acyl-carrier-protein] synthase activity
PGE45_03215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PGE45_03220	COG0802	atpase or kinase
PGE45_03245	COG1053	succinate dehydrogenase
PGE45_03250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PGE45_03260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PGE45_03270	COG1132	(ABC) transporter
PGE45_03270	COG2375	cellular response to nickel ion
PGE45_03275	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
PGE45_03285	COG2949	membrane
PGE45_03290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PGE45_03310	COG0516	GMP reductase activity
PGE45_03315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PGE45_03320	COG4975	Glucose uptake
PGE45_03355	COG0328	RNA-DNA hybrid ribonuclease activity
PGE45_03365	COG2197	response regulator
PGE45_03370	COG4585	Histidine kinase
PGE45_03385	COG1131	(ABC) transporter
PGE45_03390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PGE45_03420	COG1082	Xylose isomerase domain protein TIM barrel
PGE45_03425	COG2814	Major facilitator Superfamily
PGE45_03430	COG0673	inositol 2-dehydrogenase activity
PGE45_03440	COG2017	converts alpha-aldose to the beta-anomer
PGE45_03445	COG0673	inositol 2-dehydrogenase activity
PGE45_03450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PGE45_03455	COG2188	Transcriptional regulator
PGE45_03470	COG3718	enzyme involved in inositol metabolism
PGE45_03475	COG3962	Belongs to the TPP enzyme family
PGE45_03485	COG2814	Major facilitator Superfamily
PGE45_03505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PGE45_03505	COG0519	Catalyzes the synthesis of GMP from XMP
PGE45_03525	COG1131	(ABC) transporter
PGE45_03530	COG4585	Histidine kinase
PGE45_03570	COG2267	carboxylic ester hydrolase activity
PGE45_03580	COG3654	unkown
PGE45_03590	COG1401	restriction endodeoxyribonuclease activity
PGE45_03595	COG4268	DNA restriction-modification system
PGE45_03600	COG2826	transposase and inactivated derivatives, IS30 family
PGE45_03610	COG3842	ATPase activity
PGE45_03620	COG1840	ABC-type Fe3 transport system, periplasmic component
PGE45_03625	COG0745	RESPONSE REGULATOR receiver
PGE45_03630	COG5002	protein histidine kinase activity
PGE45_03655	COG2205	protein histidine kinase activity
PGE45_03660	COG2197	response regulator
PGE45_03670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PGE45_03680	COG0356	it plays a direct role in the translocation of protons across the membrane
PGE45_03690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PGE45_03695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PGE45_03700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PGE45_03705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PGE45_03710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PGE45_03715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PGE45_03725	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
PGE45_03770	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PGE45_03775	COG0830	nickel cation binding
PGE45_03785	COG0804	urea catabolic process
PGE45_03790	COG0832	Belongs to the urease beta subunit family
PGE45_03800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PGE45_03805	COG0254	rRNA binding
PGE45_03810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PGE45_03815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PGE45_03820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PGE45_03830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PGE45_03835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PGE45_03840	COG1621	beta-fructofuranosidase activity
PGE45_03860	COG1254	Belongs to the acylphosphatase family
PGE45_03870	COG1136	(ABC) transporter
PGE45_03870	COG0577	efflux transmembrane transporter activity
PGE45_03875	COG1136	(ABC) transporter
PGE45_03875	COG0577	efflux transmembrane transporter activity
PGE45_03885	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PGE45_03890	COG1349	DNA-binding transcription factor activity
PGE45_03910	COG1744	ABC transporter substrate-binding protein PnrA-like
PGE45_03915	COG3845	ABC transporter
PGE45_03920	COG4603	Belongs to the binding-protein-dependent transport system permease family
PGE45_03925	COG1079	Belongs to the binding-protein-dependent transport system permease family
PGE45_03950	COG0803	Belongs to the bacterial solute-binding protein 9 family
PGE45_03955	COG1121	(ABC) transporter
PGE45_03970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PGE45_03975	COG1611	Belongs to the LOG family
PGE45_03990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PGE45_04005	COG2239	Acts as a magnesium transporter
PGE45_04015	COG1082	Xylose isomerase domain protein TIM barrel
PGE45_04030	COG0006	proline dipeptidase activity
PGE45_04035	COG0673	inositol 2-dehydrogenase activity
PGE45_04045	COG2095	MarC family integral membrane protein
PGE45_04050	COG0513	Belongs to the DEAD box helicase family
PGE45_04075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PGE45_04095	COG0114	fumarate hydratase activity
PGE45_04115	COG1174	glycine betaine transport
PGE45_04145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PGE45_04175	COG1674	ftsk spoiiie
PGE45_04180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PGE45_04190	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PGE45_04195	COG0154	amidase activity
PGE45_04200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PGE45_04230	COG2966	Psort location CytoplasmicMembrane, score
PGE45_04235	COG0569	domain protein
PGE45_04235	COG2985	domain, Protein
PGE45_04250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PGE45_04265	COG0473	3-isopropylmalate dehydrogenase activity
PGE45_04280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PGE45_04285	COG1316	TRANSCRIPTIONal
PGE45_04290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PGE45_04295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PGE45_04300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PGE45_04320	COG1216	Glycosyl transferase, family 2
PGE45_04330	COG1134	teichoic acid transport
PGE45_04350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PGE45_04360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PGE45_04380	COG0515	serine threonine protein kinase
PGE45_04385	COG0842	Transport permease protein
PGE45_04385	COG1131	(ABC) transporter
PGE45_04385	COG1716	ATPase activity
PGE45_04395	COG1162	GTPase activity
PGE45_04400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PGE45_04415	COG2884	Cell division ATP-binding protein ftsE
PGE45_04420	COG2177	Part of the ABC transporter FtsEX involved in
PGE45_04460	COG0747	negative chemotaxis
PGE45_04470	COG0444	Belongs to the ABC transporter superfamily
PGE45_04475	COG4608	Belongs to the ABC transporter superfamily
PGE45_04480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PGE45_04485	COG1940	carbohydrate kinase activity
PGE45_04490	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PGE45_04510	COG0363	glucosamine-6-phosphate deaminase activity
PGE45_04530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PGE45_04540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PGE45_04560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PGE45_04565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PGE45_04620	COG3304	Inner membrane component domain
PGE45_04625	COG2040	homocysteine
PGE45_04650	COG1115	amino acid carrier protein
PGE45_04655	COG1115	amino acid carrier protein
PGE45_04660	COG1115	amino acid carrier protein
PGE45_04665	COG1115	amino acid carrier protein
PGE45_04670	COG0179	Fumarylacetoacetate (FAA) hydrolase
PGE45_04680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PGE45_04710	COG0726	polysaccharide deacetylase
PGE45_04715	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PGE45_04725	COG1674	ftsk spoiiie
PGE45_04740	COG1058	Belongs to the CinA family
PGE45_04740	COG1546	Belongs to the CinA family
PGE45_04745	COG1396	sequence-specific DNA binding
PGE45_04755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PGE45_04760	COG2137	regulation of response to DNA damage stimulus
PGE45_04770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PGE45_04780	COG0395	ABC-type sugar transport system, permease component
PGE45_04795	COG1940	carbohydrate kinase activity
PGE45_04795	COG1846	Transcriptional regulator
PGE45_04800	COG1252	NADH dehydrogenase
PGE45_04805	COG0509	glycine decarboxylation via glycine cleavage system
PGE45_04810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PGE45_04815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PGE45_04815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PGE45_04820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PGE45_04835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PGE45_04840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PGE45_04845	COG1114	Component of the transport system for branched-chain amino acids
PGE45_04855	COG2813	Specifically methylates the guanine in position
PGE45_04865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PGE45_04880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PGE45_04890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PGE45_04905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PGE45_04910	COG0066	3-isopropylmalate dehydratase activity
PGE45_04915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PGE45_04925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PGE45_04930	COG1181	Belongs to the D-alanine--D-alanine ligase family
PGE45_04940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PGE45_04945	COG1461	Dihydroxyacetone kinase
PGE45_04960	COG0235	Class ii aldolase
PGE45_04970	COG1070	Carbohydrate kinase
PGE45_04975	COG4154	Belongs to the RbsD FucU family
PGE45_04980	COG0738	Major facilitator superfamily
PGE45_04985	COG1609	Transcriptional regulator
PGE45_04990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PGE45_05005	COG0571	ribonuclease III activity
PGE45_05010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PGE45_05025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PGE45_05030	COG4988	ABC transporter
PGE45_05035	COG1294	oxidase, subunit
PGE45_05040	COG1271	oxidase subunit
PGE45_05045	COG1530	ribonuclease E activity
PGE45_05050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PGE45_05055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PGE45_05060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PGE45_05065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PGE45_05070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PGE45_05075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PGE45_05085	COG0745	RESPONSE REGULATOR receiver
PGE45_05090	COG5002	protein histidine kinase activity
PGE45_05095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PGE45_05110	COG1132	(ABC) transporter
PGE45_05115	COG0297	glycogen (starch) synthase activity
PGE45_05125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PGE45_05130	COG1349	DNA-binding transcription factor activity
PGE45_05140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PGE45_05150	COG0799	negative regulation of ribosome biogenesis
PGE45_05155	COG0406	alpha-ribazole phosphatase activity
PGE45_05170	COG2095	MarC family integral membrane protein
PGE45_05185	COG0813	purine-nucleoside phosphorylase activity
PGE45_05190	COG0733	neurotransmitter:sodium symporter activity
PGE45_05220	COG0537	adenosine 5'-monophosphoramidase activity
PGE45_05230	COG0495	leucyl-tRNA aminoacylation
PGE45_05240	COG0433	COG0433 Predicted ATPase
PGE45_05245	COG0438	transferase activity, transferring glycosyl groups
PGE45_05255	COG1555	photosystem II stabilization
PGE45_05270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PGE45_05275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PGE45_05275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PGE45_05290	COG4868	Belongs to the UPF0371 family
PGE45_05295	COG0268	Binds directly to 16S ribosomal RNA
PGE45_05315	COG0159	tryptophan synthase activity
PGE45_05330	COG0512	Glutamine amidotransferase of anthranilate synthase
PGE45_05335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PGE45_05340	COG1404	Belongs to the peptidase S8 family
PGE45_05350	COG0481	GTPase activity
PGE45_05360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PGE45_05365	COG2807	transmembrane transport
PGE45_05380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PGE45_05395	COG1420	regulation of RNA biosynthetic process
PGE45_05400	COG0484	heat shock protein binding
PGE45_05405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PGE45_05435	COG0842	Transport permease protein
PGE45_05490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PGE45_05500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PGE45_05505	COG0506	proline dehydrogenase activity
PGE45_05505	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PGE45_05505	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PGE45_05510	COG3609	addiction module antidote protein, CC2985 family
PGE45_05515	COG2337	Toxic component of a toxin-antitoxin (TA) module
PGE45_05520	COG1476	TRANSCRIPTIONal
PGE45_05530	COG1131	(ABC) transporter
PGE45_05535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PGE45_05540	COG1381	Involved in DNA repair and RecF pathway recombination
PGE45_05545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PGE45_05555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PGE45_05570	COG0423	glycine-tRNA ligase activity
PGE45_05595	COG0560	Phosphoserine phosphatase
PGE45_05605	COG0297	glycogen (starch) synthase activity
PGE45_05615	COG1119	ATPase activity
PGE45_05645	COG0488	(ABC) transporter
PGE45_05655	COG0545	Peptidyl-prolyl cis-trans isomerase
PGE45_05690	COG0205	6-phosphofructokinase activity
PGE45_05695	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PGE45_05700	COG0515	serine threonine protein kinase
PGE45_05700	COG2815	serine threonine protein kinase
PGE45_05705	COG0142	geranyltranstransferase activity
PGE45_05710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PGE45_05735	COG0187	DNA topoisomerase II activity
PGE45_05740	COG0456	acetyltransferase
PGE45_05740	COG0454	-acetyltransferase
PGE45_05750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PGE45_05795	COG0569	domain protein
PGE45_05800	COG0531	amino acid
PGE45_05805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PGE45_05810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PGE45_05820	COG1309	transcriptional regulator
PGE45_05825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PGE45_05840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PGE45_05845	COG4221	oxidoreductase activity
PGE45_05850	COG1881	PFAM PEBP family protein
PGE45_05865	COG0671	phosphoesterase, PA-phosphatase related
PGE45_05870	COG1435	thymidine kinase activity
PGE45_05890	COG0587	DNA-directed DNA polymerase activity
PGE45_05930	COG0477	Major facilitator Superfamily
PGE45_05940	COG0339	signal peptide processing
PGE45_05945	COG1252	NADH dehydrogenase
PGE45_05955	COG4607	ABC-type enterochelin transport system periplasmic component
PGE45_05960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PGE45_05965	COG4605	iron ion homeostasis
PGE45_05970	COG4604	ABC transporter, ATP-binding protein
PGE45_05975	COG0667	Aldo Keto reductase
PGE45_05980	COG0425	Belongs to the sulfur carrier protein TusA family
PGE45_05985	COG2391	methyltransferase activity
PGE45_05995	COG1994	Peptidase M50
PGE45_05995	COG0517	IMP dehydrogenase activity
PGE45_06000	COG2837	iron assimilation
PGE45_06015	COG1222	aaa ATPase
PGE45_06020	COG4122	O-methyltransferase activity
PGE45_06030	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PGE45_06040	COG0107	imidazoleglycerol-phosphate synthase activity
PGE45_06060	COG0134	indole-3-glycerol-phosphate synthase activity
PGE45_06090	COG2050	protein possibly involved in aromatic compounds catabolism
PGE45_06100	COG0539	negative regulation of cytoplasmic translation
PGE45_06110	COG0237	dephospho-CoA kinase activity
PGE45_06115	COG0556	nucleotide-excision repair
PGE45_06175	COG0322	excinuclease ABC activity
PGE45_06180	COG3585	molybdate ion transport
PGE45_06195	COG1660	Displays ATPase and GTPase activities
PGE45_06205	COG1481	regulation of sporulation
PGE45_06210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PGE45_06215	COG0126	phosphoglycerate kinase activity
PGE45_06220	COG0149	triose-phosphate isomerase activity
PGE45_06225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PGE45_06245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PGE45_06260	COG1160	GTP binding
PGE45_06280	COG0166	Belongs to the GPI family
PGE45_06285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PGE45_06315	COG0363	glucosamine-6-phosphate deaminase activity
PGE45_06330	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PGE45_06340	COG1716	ATPase activity
PGE45_06360	COG0667	Aldo Keto reductase
PGE45_06365	COG0443	Heat shock 70 kDa protein
PGE45_06380	COG1621	beta-fructofuranosidase activity
PGE45_06385	COG2190	(PTS) system
PGE45_06385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PGE45_06385	COG1263	PTS System
PGE45_06390	COG1609	Transcriptional regulator
PGE45_06400	COG1136	(ABC) transporter
PGE45_06405	COG0577	efflux transmembrane transporter activity
PGE45_06410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PGE45_06415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PGE45_06425	COG0205	6-phosphofructokinase activity
PGE45_06435	COG1216	Glycosyl transferase, family 2
PGE45_06440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PGE45_06445	COG2354	Protein conserved in bacteria
PGE45_06460	COG0805	protein transport
PGE45_06465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PGE45_06485	COG4585	Histidine kinase
PGE45_06490	COG2197	response regulator
PGE45_06495	COG1131	(ABC) transporter
PGE45_06515	COG0140	phosphoribosyl-ATP diphosphatase activity
PGE45_06520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PGE45_06525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PGE45_06530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PGE45_06535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PGE45_06545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PGE45_06550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PGE45_06555	COG4770	biotin carboxylase activity
PGE45_06560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PGE45_06570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PGE45_06585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PGE45_06590	COG0549	Belongs to the carbamate kinase family
PGE45_06605	COG0477	Major facilitator Superfamily
PGE45_06620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PGE45_06630	COG1758	RNA polymerase activity
PGE45_06635	COG0194	GDP metabolic process
PGE45_06645	COG0284	orotidine-5'-phosphate decarboxylase activity
PGE45_06650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PGE45_06660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PGE45_06665	COG0540	Belongs to the ATCase OTCase family
PGE45_06670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PGE45_06695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PGE45_06700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PGE45_06710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PGE45_06715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PGE45_06720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PGE45_06730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PGE45_06735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PGE45_06740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PGE45_06750	COG0009	L-threonylcarbamoyladenylate synthase
PGE45_06775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PGE45_06805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PGE45_06805	COG1116	anion transmembrane transporter activity
PGE45_06835	COG0124	histidyl-tRNA synthetase
PGE45_06850	COG1196	nuclear chromosome segregation
PGE45_06860	COG0789	Transcriptional regulator
PGE45_06870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PGE45_06875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PGE45_06880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PGE45_06885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PGE45_06895	COG2255	four-way junction helicase activity
PGE45_06900	COG0632	four-way junction helicase activity
PGE45_06905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PGE45_06910	COG0217	transcriptional regulatory protein
PGE45_06915	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PGE45_06920	COG1051	belongs to the nudix hydrolase family
PGE45_06925	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PGE45_06940	COG0438	transferase activity, transferring glycosyl groups
PGE45_06960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PGE45_07020	COG1882	Formate acetyltransferase
PGE45_07030	COG1073	alpha beta
PGE45_07035	COG0038	chloride channel
PGE45_07045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PGE45_07050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PGE45_07055	COG0508	dehydrogenase complex catalyzes the overall conversion of
PGE45_07085	COG0321	lipoyl(octanoyl) transferase activity
PGE45_07090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PGE45_07110	COG0765	amino acid transport
PGE45_07115	COG1126	abc transporter atp-binding protein
PGE45_07135	COG2423	ornithine cyclodeaminase activity
PGE45_07170	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PGE45_07175	COG0174	glutamine synthetase
PGE45_07180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PGE45_07200	COG3022	response to hydroperoxide
PGE45_07210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PGE45_07230	COG0436	Aminotransferase
PGE45_07280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PGE45_07295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PGE45_07305	COG1027	Aspartate ammonia-lyase
PGE45_07315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PGE45_07320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PGE45_07345	COG0358	DNA primase activity
PGE45_07360	COG2182	Extracellular solute-binding protein
PGE45_07370	COG3833	ABC-type maltose transport systems, permease component
PGE45_07375	COG1609	Transcriptional regulator
PGE45_07395	COG0167	dihydroorotate dehydrogenase activity
PGE45_07415	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PGE45_07430	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PGE45_07445	COG3189	MarR family transcriptional regulator
PGE45_07450	COG2151	metal-sulfur cluster biosynthetic enzyme
PGE45_07455	COG0822	iron-sulfur transferase activity
PGE45_07465	COG0396	ATPase activity
PGE45_07470	COG0719	Fe-S assembly protein
PGE45_07485	COG0494	nUDIX hydrolase
PGE45_07515	COG0497	DNA recombination
PGE45_07520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PGE45_07535	COG0647	UMP catabolic process
PGE45_07565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PGE45_07570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PGE45_07585	COG2094	Belongs to the DNA glycosylase MPG family
PGE45_07590	COG0165	Argininosuccinate lyase
PGE45_07595	COG2116	formate transmembrane transporter activity
PGE45_07600	COG0137	argininosuccinate synthase activity
PGE45_07605	COG1438	arginine binding
PGE45_07610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PGE45_07615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PGE45_07625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PGE45_07640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PGE45_07650	COG1131	(ABC) transporter
PGE45_07665	COG0765	amino acid transport
PGE45_07670	COG0765	amino acid transport
PGE45_07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PGE45_07680	COG1126	abc transporter atp-binding protein
PGE45_07695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PGE45_07700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PGE45_07705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PGE45_07710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PGE45_07720	COG4133	protoheme IX ABC transporter activity
PGE45_07735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PGE45_07740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PGE45_07755	COG0131	Imidazoleglycerol-phosphate dehydratase
PGE45_07765	COG0025	NhaP-type Na H and K H
PGE45_07770	COG0514	ATP-dependent DNA helicase (RecQ)
PGE45_07785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PGE45_07795	COG1215	transferase activity, transferring glycosyl groups
PGE45_07805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PGE45_07810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PGE45_07830	COG2501	S4 domain
PGE45_07835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PGE45_07840	COG0587	DNA-directed DNA polymerase activity
PGE45_07845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PGE45_07860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PGE45_07865	COG3599	regulation of cell shape
PGE45_07875	COG1799	cell septum assembly
PGE45_07880	COG1496	oxidoreductase activity
PGE45_07885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PGE45_07895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PGE45_07910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PGE45_07915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PGE45_07920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PGE45_07925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PGE45_07930	COG0768	penicillin binding
PGE45_07940	COG0275	rRNA processing
PGE45_07945	COG2001	Belongs to the MraZ family
PGE45_07955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PGE45_07975	COG0318	PFAM AMP-dependent synthetase and ligase
PGE45_07980	COG0318	PFAM AMP-dependent synthetase and ligase
PGE45_08000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PGE45_08005	COG0300	oxidoreductase activity
PGE45_08010	COG0612	Peptidase, M16
PGE45_08015	COG1185	polyribonucleotide nucleotidyltransferase activity
PGE45_08020	COG1454	alcohol dehydrogenase
PGE45_08030	COG0196	riboflavin kinase activity
PGE45_08040	COG1136	(ABC) transporter
PGE45_08040	COG0577	efflux transmembrane transporter activity
PGE45_08050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PGE45_08055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PGE45_08065	COG0330	HflC and HflK could
PGE45_08085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PGE45_08120	COG0442	prolyl-tRNA aminoacylation
PGE45_08155	COG0456	acetyltransferase
PGE45_08160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PGE45_08165	COG0750	zinc metalloprotease
PGE45_08170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PGE45_08180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PGE45_08190	COG0233	cytoplasmic translational termination
PGE45_08200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PGE45_08205	COG0052	Belongs to the universal ribosomal protein uS2 family
PGE45_08215	COG4974	Belongs to the 'phage' integrase family
PGE45_08225	COG1716	ATPase activity
PGE45_08245	COG0792	nuclease activity
PGE45_08255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PGE45_08260	COG0681	Belongs to the peptidase S26 family
PGE45_08270	COG0681	Belongs to the peptidase S26 family
PGE45_08275	COG0336	Belongs to the RNA methyltransferase TrmD family
PGE45_08280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PGE45_08285	COG1837	Belongs to the UPF0109 family
PGE45_08315	COG4585	Histidine kinase
PGE45_08320	COG2197	response regulator
PGE45_08330	COG1131	(ABC) transporter
PGE45_08335	COG0842	Transport permease protein
PGE45_08340	COG4585	Histidine kinase
PGE45_08345	COG2197	response regulator
PGE45_08360	COG1196	nuclear chromosome segregation
PGE45_08365	COG4152	abc transporter atp-binding protein
PGE45_08375	COG0105	UTP biosynthetic process
PGE45_08380	COG1461	Dihydroxyacetone kinase
PGE45_08385	COG0285	dihydrofolate synthase activity
PGE45_08390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PGE45_08420	COG0438	transferase activity, transferring glycosyl groups
PGE45_08425	COG1215	transferase activity, transferring glycosyl groups
PGE45_08430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PGE45_08435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PGE45_08460	COG0656	L-ascorbic acid biosynthetic process
PGE45_08470	COG4221	oxidoreductase activity
PGE45_08475	COG2056	Na+-H+ antiporter family
PGE45_08480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PGE45_08485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PGE45_08490	COG0175	sulfate reduction
PGE45_08505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PGE45_08505	COG1648	precorrin-2 dehydrogenase activity
PGE45_08510	COG0730	response to heat
PGE45_08540	COG1132	(ABC) transporter
PGE45_08540	COG2375	cellular response to nickel ion
PGE45_08545	COG1122	ATPase activity
PGE45_08555	COG1129	ABC transporter
PGE45_08570	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PGE45_08580	COG4122	O-methyltransferase activity
PGE45_08585	COG1222	aaa ATPase
PGE45_08605	COG0366	Alpha amylase catalytic
PGE45_08620	COG1653	transport
PGE45_08635	COG1605	Chorismate mutase
PGE45_08635	COG0287	Prephenate dehydrogenase
PGE45_08640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PGE45_08645	COG0740	serine-type endopeptidase activity
PGE45_08665	COG0544	peptidyl-prolyl cis-trans isomerase activity
PGE45_08685	COG1739	Uncharacterized protein family UPF0029
PGE45_08695	COG1045	serine acetyltransferase
PGE45_08710	COG0698	ribose 5-phosphate isomerase
PGE45_08715	COG3590	peptidase
PGE45_08740	COG1263	PTS System
PGE45_08745	COG2188	Transcriptional regulator
PGE45_08750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PGE45_08765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PGE45_08770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PGE45_08800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PGE45_08875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PGE45_08880	COG2326	polyphosphate kinase activity
PGE45_08890	COG1615	UPF0182 protein
PGE45_08905	COG3480	Lon protease (S16) C-terminal proteolytic domain
PGE45_08970	COG3177	Filamentation induced by cAMP protein fic
PGE45_08975	COG0482	sulfurtransferase activity
PGE45_08985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PGE45_09025	COG0366	Alpha amylase catalytic
PGE45_09035	COG3281	Trehalose synthase
PGE45_09040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PGE45_09045	COG0058	SHG alpha-glucan phosphorylase activity
PGE45_09080	COG0395	ABC-type sugar transport system, permease component
PGE45_09085	COG1175	transmembrane transport
PGE45_09095	COG0039	L-malate dehydrogenase activity
PGE45_09100	COG4988	ABC transporter
PGE45_09105	COG1132	(ABC) transporter
PGE45_09140	COG0045	succinate-CoA ligase (ADP-forming) activity
PGE45_09150	COG0205	6-phosphofructokinase activity
PGE45_09170	COG0366	Alpha amylase catalytic
PGE45_09175	COG1501	Belongs to the glycosyl hydrolase 31 family
PGE45_09180	COG0110	maltose O-acetyltransferase activity
PGE45_09205	COG0604	alcohol dehydrogenase
PGE45_09210	COG1846	Transcriptional regulator
PGE45_09220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PGE45_09225	COG0254	rRNA binding
PGE45_09235	COG0431	NADPH-dependent FMN reductase
PGE45_09240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PGE45_09245	COG0083	homoserine kinase activity
PGE45_09250	COG0460	homoserine dehydrogenase
PGE45_09265	COG0019	diaminopimelate decarboxylase activity
PGE45_09270	COG0018	arginyl-trna synthetase
PGE45_09350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PGE45_09400	COG1192	Involved in chromosome partitioning
PGE45_09460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PGE45_09520	COG0739	heme binding
PGE45_09530	COG1253	flavin adenine dinucleotide binding
PGE45_09545	COG0508	dehydrogenase complex catalyzes the overall conversion of
PGE45_09545	COG0567	Dehydrogenase, E1 component
PGE45_09565	COG1595	DNA-templated transcription, initiation
PGE45_09575	COG2838	Isocitrate dehydrogenase
PGE45_09580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PGE45_09585	COG1162	GTPase activity
PGE45_09615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PGE45_09625	COG0314	molybdopterin synthase activity
PGE45_09635	COG0315	cyclic pyranopterin monophosphate synthase activity
PGE45_09645	COG0521	Mo-molybdopterin cofactor biosynthetic process
PGE45_09645	COG0315	cyclic pyranopterin monophosphate synthase activity
PGE45_09660	COG1140	nitrate reductase beta subunit
PGE45_09685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PGE45_09710	COG2249	NAD(P)H dehydrogenase (quinone) activity
PGE45_09715	COG0456	acetyltransferase
PGE45_09720	COG2249	NAD(P)H dehydrogenase (quinone) activity
PGE45_09725	COG0483	inositol monophosphate 1-phosphatase activity
PGE45_09735	COG1968	undecaprenyl-diphosphatase activity
PGE45_09755	COG0420	3'-5' exonuclease activity
PGE45_09760	COG0419	ATPase involved in DNA repair
PGE45_09790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PGE45_09795	COG0085	RNA polymerase activity
PGE45_09810	COG0222	ribosome binding
PGE45_09815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PGE45_09855	COG0653	protein targeting
PGE45_09860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PGE45_09865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PGE45_09870	COG5401	PFAM Sporulation and spore germination
PGE45_09875	COG5002	protein histidine kinase activity
PGE45_09875	COG5000	phosphorelay sensor kinase activity
PGE45_09880	COG0745	RESPONSE REGULATOR receiver
PGE45_09900	COG0714	Associated with various cellular activities
PGE45_09905	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
PGE45_09920	COG2835	tetraacyldisaccharide 4'-kinase activity
PGE45_09955	COG1482	cell wall glycoprotein biosynthetic process
PGE45_09980	COG0438	transferase activity, transferring glycosyl groups
PGE45_09995	COG1215	transferase activity, transferring glycosyl groups
PGE45_10040	COG0463	Glycosyl transferase, family 2
PGE45_10055	COG1088	dTDP-glucose 4,6-dehydratase activity
PGE45_10070	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PGE45_10085	COG0297	glycogen (starch) synthase activity
PGE45_10100	COG0438	transferase activity, transferring glycosyl groups
PGE45_10120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PGE45_10125	COG0438	transferase activity, transferring glycosyl groups
PGE45_10150	COG1316	TRANSCRIPTIONal
PGE45_10155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PGE45_10185	COG5002	protein histidine kinase activity
PGE45_10190	COG0745	RESPONSE REGULATOR receiver
PGE45_10205	COG0424	maF-like protein
PGE45_10220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PGE45_10240	COG1666	GTP binding
PGE45_10245	COG2197	response regulator
PGE45_10265	COG0501	Belongs to the peptidase M48B family
PGE45_10280	COG1137	ATPase activity
PGE45_10285	COG1994	Peptidase M50
PGE45_10305	COG0142	geranyltranstransferase activity
PGE45_10310	COG1007	ATP synthesis coupled electron transport
PGE45_10320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PGE45_10325	COG0713	ATP synthesis coupled electron transport
PGE45_10340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PGE45_10345	COG1034	ATP synthesis coupled electron transport
PGE45_10350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PGE45_10360	COG0649	NAD binding
PGE45_10365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PGE45_10370	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PGE45_10380	COG0644	oxidoreductase
PGE45_10385	COG2226	methyltransferase
PGE45_10390	COG1169	isochorismate synthase
PGE45_10405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PGE45_10410	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PGE45_10415	COG4948	Mandelate Racemase Muconate Lactonizing
PGE45_10435	COG4176	ABC-type proline glycine betaine transport system permease component
PGE45_10445	COG1940	carbohydrate kinase activity
PGE45_10450	COG5426	von Willebrand factor, type A
PGE45_10460	COG1175	transmembrane transport
PGE45_10465	COG0395	ABC-type sugar transport system, permease component
PGE45_10480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PGE45_10485	COG2235	arginine
PGE45_10500	COG2197	response regulator
PGE45_10505	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PGE45_10530	COG3477	response to acidic pH
PGE45_10545	COG1397	ADP-ribosylglycohydrolase
PGE45_10550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PGE45_10550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PGE45_10570	COG0406	alpha-ribazole phosphatase activity
PGE45_10575	COG2171	N-acyltransferase activity
PGE45_10585	COG1053	succinate dehydrogenase
PGE45_10650	COG1217	gtp-binding protein TYPA
PGE45_10685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PGE45_10690	COG0601	transmembrane transport
PGE45_10700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PGE45_10710	COG2267	carboxylic ester hydrolase activity
PGE45_10725	COG1902	pentaerythritol trinitrate reductase activity
PGE45_10730	COG3012	SEC-C Motif Domain Protein
PGE45_10735	COG1362	aminopeptidase activity
PGE45_10740	COG0546	phosphoglycolate phosphatase activity
PGE45_10840	COG0698	ribose 5-phosphate isomerase
PGE45_10850	COG0730	response to heat
PGE45_10855	COG0641	radical SAM
PGE45_10860	COG1940	carbohydrate kinase activity
PGE45_10865	COG3119	arylsulfatase activity
PGE45_10870	COG2814	Major facilitator Superfamily
PGE45_10870	COG0477	Major facilitator Superfamily
PGE45_10875	COG0596	Alpha beta hydrolase
PGE45_10875	COG0508	dehydrogenase complex catalyzes the overall conversion of
PGE45_10890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PGE45_10900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PGE45_10900	COG0574	Belongs to the PEP-utilizing enzyme family
PGE45_10915	COG2211	Major facilitator Superfamily
PGE45_10925	COG0297	glycogen (starch) synthase activity
PGE45_10925	COG0438	transferase activity, transferring glycosyl groups
PGE45_11015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PGE45_11030	COG1490	D-aminoacyl-tRNA deacylase activity
PGE45_11040	COG0354	folic acid binding
PGE45_11045	COG3485	protocatechuate 3,4-dioxygenase
PGE45_11055	COG0745	RESPONSE REGULATOR receiver
PGE45_11060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PGE45_11080	COG0494	nUDIX hydrolase
PGE45_11080	COG0406	alpha-ribazole phosphatase activity
PGE45_11085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PGE45_11110	COG0513	Belongs to the DEAD box helicase family
PGE45_11115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PGE45_11125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PGE45_11130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PGE45_11165	COG0431	NADPH-dependent FMN reductase
PGE45_11170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PGE45_11180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PGE45_11195	COG0444	Belongs to the ABC transporter superfamily
PGE45_11230	COG4585	Histidine kinase
PGE45_11235	COG2197	response regulator
PGE45_11240	COG0193	aminoacyl-tRNA hydrolase activity
PGE45_11245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PGE45_11260	COG0710	3-dehydroquinate dehydratase activity
PGE45_11280	COG0148	phosphopyruvate hydratase activity
PGE45_11305	COG0745	RESPONSE REGULATOR receiver
PGE45_11310	COG2205	protein histidine kinase activity
PGE45_11325	COG0459	protein refolding
PGE45_11340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PGE45_11350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PGE45_11355	COG0215	cysteine-tRNA ligase activity
PGE45_11360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PGE45_11380	COG3842	ATPase activity
PGE45_11410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PGE45_11430	COG0561	phosphatase activity
PGE45_11450	COG3716	PTS system mannose fructose sorbose family IID component
PGE45_11455	COG3715	PTS system
PGE45_11460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PGE45_11460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PGE45_11465	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PGE45_11480	COG1621	beta-fructofuranosidase activity
PGE45_11485	COG1609	Transcriptional regulator
PGE45_11490	COG0546	phosphoglycolate phosphatase activity
PGE45_11495	COG1309	transcriptional regulator
PGE45_11515	COG0542	response to heat
PGE45_11535	COG3655	Transcriptional regulator
PGE45_11550	COG1136	(ABC) transporter
PGE45_11550	COG0577	efflux transmembrane transporter activity
PGE45_11570	COG0745	RESPONSE REGULATOR receiver
PGE45_11575	COG2205	protein histidine kinase activity
PGE45_11595	COG2311	Membrane
PGE45_11600	COG0789	Transcriptional regulator
PGE45_11605	COG0484	heat shock protein binding
PGE45_11610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PGE45_11615	COG0443	Heat shock 70 kDa protein
PGE45_11635	COG2814	Major facilitator Superfamily
PGE45_11640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PGE45_11650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PGE45_11655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PGE45_11680	COG2197	response regulator
PGE45_11685	COG4585	Histidine kinase
PGE45_11690	COG1131	(ABC) transporter
PGE45_11735	COG0778	Nitroreductase
PGE45_11740	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
PGE45_11830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PGE45_11900	COG3842	ATPase activity
PGE45_11935	COG0247	lactate metabolic process
PGE45_11935	COG2181	nitrate reductase activity
PGE45_11975	COG3842	ATPase activity
PGE45_11985	COG2197	response regulator
PGE45_12050	COG2197	response regulator
PGE45_12080	COG0515	serine threonine protein kinase
PGE45_12100	COG1131	(ABC) transporter
PGE45_12125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PGE45_12140	COG3851	Histidine kinase
PGE45_12145	COG2197	response regulator
PGE45_12155	COG2755	lipolytic protein G-D-S-L family
PGE45_12170	COG0483	inositol monophosphate 1-phosphatase activity
PGE45_12175	COG1113	amino acid transport
PGE45_12185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PGE45_12190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PGE45_12195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PGE45_12195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PGE45_12200	COG1940	carbohydrate kinase activity
PGE45_12205	COG0628	permease
PGE45_12215	COG1854	S-ribosylhomocysteine lyase activity
PGE45_12225	COG2409	Drug exporters of the RND superfamily
PGE45_12250	COG0789	Transcriptional regulator
PGE45_12255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PGE45_12265	COG0569	domain protein
PGE45_12265	COG2985	domain, Protein
PGE45_12270	COG1966	Carbon starvation protein
PGE45_12290	COG1716	ATPase activity
PGE45_12295	COG1716	ATPase activity
PGE45_12310	COG0768	penicillin binding
PGE45_12315	COG0515	serine threonine protein kinase
PGE45_12320	COG2815	serine threonine protein kinase
PGE45_12320	COG0515	serine threonine protein kinase
PGE45_12325	COG2197	response regulator
PGE45_12330	COG4585	Histidine kinase
PGE45_12345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PGE45_12350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PGE45_12390	COG3345	alpha-galactosidase
PGE45_12395	COG0673	inositol 2-dehydrogenase activity
PGE45_12400	COG0617	tRNA 3'-terminal CCA addition
PGE45_12415	COG0728	peptidoglycan biosynthetic process
PGE45_12420	COG0492	ferredoxin-NADP+ reductase activity
PGE45_12425	COG3118	belongs to the thioredoxin family
PGE45_12435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PGE45_12440	COG1181	Belongs to the D-alanine--D-alanine ligase family
PGE45_12460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PGE45_12475	COG1309	transcriptional regulator
PGE45_12565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PGE45_12570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PGE45_12570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PGE45_12580	COG0714	Associated with various cellular activities
PGE45_12625	COG0488	(ABC) transporter
PGE45_12630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PGE45_12635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PGE45_12650	COG0084	hydrolase, TatD family'
PGE45_12655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PGE45_12665	COG1335	isochorismatase
PGE45_12705	COG1297	OPT oligopeptide transporter protein
PGE45_12710	COG1215	transferase activity, transferring glycosyl groups
PGE45_12765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PGE45_12775	COG1970	mechanosensitive ion channel activity
PGE45_12800	COG0791	NLP P60 protein
PGE45_12800	COG1388	LysM domain
PGE45_12800	COG3103	Sh3 type 3 domain protein
PGE45_12835	COG2252	PERMEase
PGE45_12840	COG1201	RNA secondary structure unwinding
PGE45_12865	COG1061	Type III restriction enzyme res subunit
PGE45_12880	COG1842	Phage shock protein A