locus-tag	class	description
CWT12_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWT12_00010	COG0592	DNA-directed DNA polymerase activity
CWT12_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWT12_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CWT12_00025	COG0187	DNA topoisomerase II activity
CWT12_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWT12_00070	COG0656	L-ascorbic acid biosynthetic process
CWT12_00080	COG3764	Sortase (surface protein transpeptidase)
CWT12_00090	COG0515	serine threonine protein kinase
CWT12_00095	COG0768	penicillin binding
CWT12_00110	COG1716	ATPase activity
CWT12_00115	COG1716	ATPase activity
CWT12_00130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CWT12_00145	COG2985	domain, Protein
CWT12_00145	COG0569	domain protein
CWT12_00150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWT12_00165	COG1854	S-ribosylhomocysteine lyase activity
CWT12_00175	COG0471	metal ion transport
CWT12_00190	COG0628	permease
CWT12_00195	COG2226	methyltransferase
CWT12_00215	COG1196	nuclear chromosome segregation
CWT12_00215	COG0741	lytic transglycosylase activity
CWT12_00215	COG0739	heme binding
CWT12_00295	COG1120	ATPase activity
CWT12_00300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_00305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_00315	COG0110	maltose O-acetyltransferase activity
CWT12_00320	COG1940	carbohydrate kinase activity
CWT12_00325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWT12_00325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWT12_00420	COG1131	(ABC) transporter
CWT12_00445	COG1937	Protein conserved in bacteria
CWT12_00455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWT12_00475	COG1950	PFAM Membrane protein of
CWT12_00480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CWT12_00545	COG3588	fructose-bisphosphate aldolase
CWT12_00565	COG2211	Major facilitator Superfamily
CWT12_00590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWT12_00610	COG2011	ABC-type metal ion transport system permease component
CWT12_00615	COG1464	Belongs to the NlpA lipoprotein family
CWT12_00625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CWT12_00630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWT12_00635	COG0037	tRNA processing
CWT12_00635	COG0590	tRNA wobble adenosine to inosine editing
CWT12_00675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CWT12_00675	COG0519	Catalyzes the synthesis of GMP from XMP
CWT12_00750	COG1674	ftsk spoiiie
CWT12_00780	COG1827	regulation of RNA biosynthetic process
CWT12_00795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWT12_00805	COG0385	Bile acid
CWT12_00810	COG3386	PFAM SMP-30 Gluconolaconase
CWT12_00820	COG1253	flavin adenine dinucleotide binding
CWT12_00825	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CWT12_00830	COG0572	uridine kinase
CWT12_00835	COG1228	amidohydrolase
CWT12_00855	COG1378	Sugar-specific transcriptional regulator TrmB
CWT12_00870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CWT12_00880	COG3842	ATPase activity
CWT12_00885	COG1178	ABC-type Fe3 transport system permease component
CWT12_00890	COG1840	ABC-type Fe3 transport system, periplasmic component
CWT12_00900	COG3852	Histidine kinase
CWT12_00930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CWT12_00940	COG1653	transport
CWT12_00945	COG0778	Nitroreductase
CWT12_00985	COG0778	Nitroreductase
CWT12_01005	COG1404	Belongs to the peptidase S8 family
CWT12_01025	COG0626	cystathionine gamma-synthase activity
CWT12_01030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CWT12_01050	COG1132	(ABC) transporter
CWT12_01090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWT12_01125	COG1201	RNA secondary structure unwinding
CWT12_01135	COG2181	nitrate reductase activity
CWT12_01135	COG0247	lactate metabolic process
CWT12_01200	COG1175	transmembrane transport
CWT12_01205	COG3842	ATPase activity
CWT12_01220	COG0151	Belongs to the GarS family
CWT12_01225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWT12_01245	COG0047	phosphoribosylformylglycinamidine synthase activity
CWT12_01250	COG0438	transferase activity, transferring glycosyl groups
CWT12_01265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWT12_01280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWT12_01285	COG0737	Belongs to the 5'-nucleotidase family
CWT12_01295	COG1349	DNA-binding transcription factor activity
CWT12_01305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWT12_01305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CWT12_01305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_01310	COG4085	toxin activity
CWT12_01310	COG1525	nuclease
CWT12_01310	COG0737	Belongs to the 5'-nucleotidase family
CWT12_01320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CWT12_01340	COG1132	(ABC) transporter
CWT12_01350	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWT12_01395	COG2723	6-phospho-beta-galactosidase activity
CWT12_01400	COG0395	ABC-type sugar transport system, permease component
CWT12_01430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWT12_01450	COG3265	gluconokinase activity
CWT12_01500	COG1192	Involved in chromosome partitioning
CWT12_01510	COG4974	Belongs to the 'phage' integrase family
CWT12_01650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CWT12_01665	COG1408	metallophosphoesterase
CWT12_01670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWT12_01695	COG0596	Alpha beta hydrolase
CWT12_01705	COG1780	Probably involved in ribonucleotide reductase function
CWT12_01715	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWT12_01755	COG1492	cobalamin metabolic process
CWT12_01805	COG2205	protein histidine kinase activity
CWT12_01810	COG0745	RESPONSE REGULATOR receiver
CWT12_01820	COG1754	DNA topoisomerase type I activity
CWT12_01820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CWT12_01830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWT12_01850	COG0252	asparaginase activity
CWT12_01865	COG0588	phosphoglycerate mutase activity
CWT12_01870	COG0704	Plays a role in the regulation of phosphate uptake
CWT12_01875	COG5002	protein histidine kinase activity
CWT12_01880	COG0745	RESPONSE REGULATOR receiver
CWT12_01885	COG1329	Transcriptional regulator
CWT12_01890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CWT12_01900	COG1764	response to oxidative stress
CWT12_01925	COG1132	(ABC) transporter
CWT12_01930	COG1132	(ABC) transporter
CWT12_01940	COG2508	Transcriptional regulator
CWT12_01960	COG2723	6-phospho-beta-galactosidase activity
CWT12_01985	COG3507	Belongs to the glycosyl hydrolase 43 family
CWT12_01990	COG3250	beta-galactosidase activity
CWT12_02000	COG2211	Major facilitator Superfamily
CWT12_02010	COG3250	beta-galactosidase activity
CWT12_02015	COG2272	Belongs to the type-B carboxylesterase lipase family
CWT12_02020	COG2211	Major facilitator Superfamily
CWT12_02025	COG1609	Transcriptional regulator
CWT12_02045	COG1070	Carbohydrate kinase
CWT12_02055	COG2814	Major facilitator Superfamily
CWT12_02125	COG1609	Transcriptional regulator
CWT12_02145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWT12_02175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_02175	COG3711	transcriptional antiterminator
CWT12_02205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_02215	COG1842	Phage shock protein A
CWT12_02230	COG1028	Short-chain dehydrogenase reductase Sdr
CWT12_02230	COG0604	alcohol dehydrogenase
CWT12_02230	COG3321	synthase
CWT12_02250	COG2252	PERMEase
CWT12_02270	COG0791	NLP P60 protein
CWT12_02300	COG1970	mechanosensitive ion channel activity
CWT12_02310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CWT12_02385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWT12_02405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CWT12_02410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CWT12_02415	COG0488	(ABC) transporter
CWT12_02460	COG0714	Associated with various cellular activities
CWT12_02470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CWT12_02470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWT12_02475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWT12_02480	COG1309	transcriptional regulator
CWT12_02530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CWT12_02565	COG2244	polysaccharide biosynthetic process
CWT12_02585	COG0148	phosphopyruvate hydratase activity
CWT12_02605	COG0710	3-dehydroquinate dehydratase activity
CWT12_02610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CWT12_02620	COG2197	response regulator
CWT12_02655	COG0129	dihydroxy-acid dehydratase activity
CWT12_02660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWT12_02665	COG0431	NADPH-dependent FMN reductase
CWT12_02680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWT12_02685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWT12_02695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWT12_02700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CWT12_02710	COG1722	exodeoxyribonuclease VII activity
CWT12_02715	COG4209	transmembrane transport
CWT12_02720	COG0395	ABC-type sugar transport system, permease component
CWT12_02730	COG1621	beta-fructofuranosidase activity
CWT12_02745	COG1570	exodeoxyribonuclease VII activity
CWT12_02750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWT12_02765	COG0012	GTP binding
CWT12_02795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CWT12_02835	COG2304	oxidoreductase activity
CWT12_02845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWT12_02855	COG0076	glutamate decarboxylase activity
CWT12_02860	COG0531	amino acid
CWT12_02870	COG0546	phosphoglycolate phosphatase activity
CWT12_02890	COG1362	aminopeptidase activity
CWT12_02895	COG1902	pentaerythritol trinitrate reductase activity
CWT12_02900	COG4667	esterase of the alpha-beta hydrolase superfamily
CWT12_02920	COG1268	BioY protein
CWT12_03005	COG1053	succinate dehydrogenase
CWT12_03020	COG0406	alpha-ribazole phosphatase activity
CWT12_03030	COG1002	Type II restriction enzyme, methylase subunits
CWT12_03040	COG1131	(ABC) transporter
CWT12_03045	COG2197	response regulator
CWT12_03080	COG1116	anion transmembrane transporter activity
CWT12_03085	COG3477	response to acidic pH
CWT12_03095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWT12_03115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWT12_03125	COG4948	Mandelate Racemase Muconate Lactonizing
CWT12_03130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CWT12_03135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWT12_03145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWT12_03150	COG0254	rRNA binding
CWT12_03155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWT12_03160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWT12_03165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWT12_03190	COG1518	maintenance of DNA repeat elements
CWT12_03205	COG1857	crispr-associated protein
CWT12_03225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CWT12_03230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWT12_03240	COG1254	Belongs to the acylphosphatase family
CWT12_03245	COG0577	efflux transmembrane transporter activity
CWT12_03245	COG1136	(ABC) transporter
CWT12_03250	COG1136	(ABC) transporter
CWT12_03250	COG0577	efflux transmembrane transporter activity
CWT12_03310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CWT12_03315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CWT12_03320	COG1611	Belongs to the LOG family
CWT12_03335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWT12_03340	COG0489	protein tyrosine kinase activity
CWT12_03340	COG2151	metal-sulfur cluster biosynthetic enzyme
CWT12_03350	COG2239	Acts as a magnesium transporter
CWT12_03360	COG1082	Xylose isomerase domain protein TIM barrel
CWT12_03370	COG0673	inositol 2-dehydrogenase activity
CWT12_03380	COG2095	MarC family integral membrane protein
CWT12_03385	COG0513	Belongs to the DEAD box helicase family
CWT12_03470	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CWT12_03510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWT12_03515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_03525	COG2190	(PTS) system
CWT12_03540	COG1349	DNA-binding transcription factor activity
CWT12_03550	COG1830	Aldolase
CWT12_03560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWT12_03565	COG1929	Belongs to the glycerate kinase type-1 family
CWT12_03570	COG1316	TRANSCRIPTIONal
CWT12_03585	COG0698	ribose 5-phosphate isomerase
CWT12_03595	COG1045	serine acetyltransferase
CWT12_03605	COG1739	Uncharacterized protein family UPF0029
CWT12_03630	COG2040	homocysteine
CWT12_03645	COG0544	peptidyl-prolyl cis-trans isomerase activity
CWT12_03660	COG0740	serine-type endopeptidase activity
CWT12_03670	COG1683	Conserved Protein
CWT12_03695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWT12_03710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CWT12_03715	COG1388	LysM domain
CWT12_03720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWT12_03735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWT12_03740	COG0066	3-isopropylmalate dehydratase activity
CWT12_03745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWT12_03755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CWT12_03765	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWT12_03775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWT12_03780	COG1461	Dihydroxyacetone kinase
CWT12_03800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWT12_03815	COG0571	ribonuclease III activity
CWT12_03835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CWT12_03850	COG1294	oxidase, subunit
CWT12_03860	COG1530	ribonuclease E activity
CWT12_03865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWT12_03870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWT12_03875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWT12_03890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CWT12_03895	COG0745	RESPONSE REGULATOR receiver
CWT12_03900	COG5002	protein histidine kinase activity
CWT12_03915	COG1132	(ABC) transporter
CWT12_03925	COG0438	transferase activity, transferring glycosyl groups
CWT12_03935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CWT12_03940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CWT12_03950	COG0799	negative regulation of ribosome biogenesis
CWT12_03955	COG0406	alpha-ribazole phosphatase activity
CWT12_03970	COG1968	undecaprenyl-diphosphatase activity
CWT12_03975	COG0483	inositol monophosphate 1-phosphatase activity
CWT12_03990	COG0110	maltose O-acetyltransferase activity
CWT12_03995	COG1063	alcohol dehydrogenase
CWT12_04000	COG1120	ATPase activity
CWT12_04005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWT12_04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_04015	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWT12_04040	COG1140	nitrate reductase beta subunit
CWT12_04055	COG0315	cyclic pyranopterin monophosphate synthase activity
CWT12_04055	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWT12_04075	COG0315	cyclic pyranopterin monophosphate synthase activity
CWT12_04095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWT12_04120	COG1162	GTPase activity
CWT12_04125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CWT12_04130	COG2838	Isocitrate dehydrogenase
CWT12_04140	COG1595	DNA-templated transcription, initiation
CWT12_04170	COG0741	lytic transglycosylase activity
CWT12_04170	COG1196	nuclear chromosome segregation
CWT12_04170	COG0739	heme binding
CWT12_04175	COG0584	glycerophosphoryl diester phosphodiesterase
CWT12_04180	COG2272	Belongs to the type-B carboxylesterase lipase family
CWT12_04215	COG0018	arginyl-trna synthetase
CWT12_04220	COG0019	diaminopimelate decarboxylase activity
CWT12_04245	COG0083	homoserine kinase activity
CWT12_04255	COG0254	rRNA binding
CWT12_04260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CWT12_04285	COG0366	Alpha amylase catalytic
CWT12_04295	COG1472	Belongs to the glycosyl hydrolase 3 family
CWT12_04305	COG0366	Alpha amylase catalytic
CWT12_04310	COG1501	Belongs to the glycosyl hydrolase 31 family
CWT12_04315	COG1609	Transcriptional regulator
CWT12_04320	COG1846	Transcriptional regulator
CWT12_04320	COG1940	carbohydrate kinase activity
CWT12_04330	COG1175	transmembrane transport
CWT12_04350	COG0205	6-phosphofructokinase activity
CWT12_04370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CWT12_04375	COG0039	L-malate dehydrogenase activity
CWT12_04390	COG0395	ABC-type sugar transport system, permease component
CWT12_04440	COG3281	Trehalose synthase
CWT12_04445	COG0366	Alpha amylase catalytic
CWT12_04465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CWT12_04470	COG1725	Transcriptional regulator
CWT12_04520	COG3480	Lon protease (S16) C-terminal proteolytic domain
CWT12_04560	COG0114	fumarate hydratase activity
CWT12_04585	COG1174	glycine betaine transport
CWT12_04600	COG1609	Transcriptional regulator
CWT12_04605	COG0673	inositol 2-dehydrogenase activity
CWT12_04615	COG2814	Major facilitator Superfamily
CWT12_04625	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CWT12_04655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWT12_04670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWT12_04675	COG0154	amidase activity
CWT12_04680	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CWT12_04710	COG0647	UMP catabolic process
CWT12_04720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CWT12_04855	COG1674	ftsk spoiiie
CWT12_04860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CWT12_04905	COG0569	domain protein
CWT12_04910	COG0531	amino acid
CWT12_04915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWT12_04920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWT12_04930	COG0674	pyruvate-flavodoxin oxidoreductase activity
CWT12_04935	COG1013	pyruvate-flavodoxin oxidoreductase activity
CWT12_04940	COG0493	'glutamate synthase
CWT12_04950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWT12_04955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CWT12_04960	COG1881	PFAM PEBP family protein
CWT12_04980	COG1435	thymidine kinase activity
CWT12_05010	COG0587	DNA-directed DNA polymerase activity
CWT12_05030	COG0546	phosphoglycolate phosphatase activity
CWT12_05035	COG0676	glucose-6-phosphate 1-epimerase activity
CWT12_05045	COG0738	Major facilitator superfamily
CWT12_05065	COG0667	Aldo Keto reductase
CWT12_05070	COG0425	Belongs to the sulfur carrier protein TusA family
CWT12_05075	COG2391	methyltransferase activity
CWT12_05090	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWT12_05095	COG1879	ABC-type sugar transport system periplasmic component
CWT12_05100	COG0517	IMP dehydrogenase activity
CWT12_05100	COG1994	Peptidase M50
CWT12_05105	COG2264	protein methyltransferase activity
CWT12_05120	COG1222	aaa ATPase
CWT12_05125	COG4122	O-methyltransferase activity
CWT12_05135	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CWT12_05145	COG0107	imidazoleglycerol-phosphate synthase activity
CWT12_05165	COG0134	indole-3-glycerol-phosphate synthase activity
CWT12_05170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CWT12_05200	COG0539	negative regulation of cytoplasmic translation
CWT12_05210	COG0237	dephospho-CoA kinase activity
CWT12_05215	COG0556	nucleotide-excision repair
CWT12_05240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWT12_05245	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CWT12_05250	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CWT12_05295	COG0561	phosphatase activity
CWT12_05310	COG3711	transcriptional antiterminator
CWT12_05315	COG2190	(PTS) system
CWT12_05315	COG1263	PTS System
CWT12_05315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_05325	COG3739	integral membrane protein
CWT12_05335	COG1660	Displays ATPase and GTPase activities
CWT12_05345	COG1481	regulation of sporulation
CWT12_05350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWT12_05360	COG0149	triose-phosphate isomerase activity
CWT12_05365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWT12_05385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWT12_05400	COG1160	GTP binding
CWT12_05405	COG0519	Catalyzes the synthesis of GMP from XMP
CWT12_05410	COG0166	Belongs to the GPI family
CWT12_05425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CWT12_05425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CWT12_05460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CWT12_05480	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CWT12_05500	COG4989	oxidoreductase activity
CWT12_05520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CWT12_05545	COG0667	Aldo Keto reductase
CWT12_05570	COG2190	(PTS) system
CWT12_05570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_05570	COG1263	PTS System
CWT12_05585	COG0205	6-phosphofructokinase activity
CWT12_05595	COG1216	Glycosyl transferase, family 2
CWT12_05610	COG0805	protein transport
CWT12_05615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWT12_05620	COG2378	regulation of single-species biofilm formation
CWT12_05635	COG0140	phosphoribosyl-ATP diphosphatase activity
CWT12_05640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CWT12_05645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWT12_05650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWT12_05665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWT12_05670	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CWT12_05670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWT12_05670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_05675	COG1461	Dihydroxyacetone kinase
CWT12_05680	COG2376	Dihydroxyacetone kinase
CWT12_05690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWT12_05695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWT12_05705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWT12_05715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWT12_05730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWT12_05740	COG1758	RNA polymerase activity
CWT12_05745	COG0194	GDP metabolic process
CWT12_05755	COG0284	orotidine-5'-phosphate decarboxylase activity
CWT12_05765	COG0505	Belongs to the CarA family
CWT12_05775	COG0540	Belongs to the ATCase OTCase family
CWT12_05780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CWT12_05785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWT12_05790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWT12_05800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWT12_05815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CWT12_05825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CWT12_05835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWT12_05845	COG0730	response to heat
CWT12_05855	COG2409	Drug exporters of the RND superfamily
CWT12_05860	COG0009	L-threonylcarbamoyladenylate synthase
CWT12_05870	COG1063	alcohol dehydrogenase
CWT12_05890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWT12_05920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWT12_05940	COG1196	nuclear chromosome segregation
CWT12_05990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWT12_05995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CWT12_06000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWT12_06005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWT12_06015	COG2255	four-way junction helicase activity
CWT12_06020	COG0632	four-way junction helicase activity
CWT12_06025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CWT12_06030	COG0217	transcriptional regulatory protein
CWT12_06050	COG0438	transferase activity, transferring glycosyl groups
CWT12_06060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CWT12_06070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWT12_06130	COG1882	Formate acetyltransferase
CWT12_06135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CWT12_06150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CWT12_06155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWT12_06175	COG0515	serine threonine protein kinase
CWT12_06175	COG2815	serine threonine protein kinase
CWT12_06180	COG0321	lipoyl(octanoyl) transferase activity
CWT12_06185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CWT12_06205	COG0765	amino acid transport
CWT12_06235	COG0174	glutamine synthetase
CWT12_06240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWT12_06250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CWT12_06250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CWT12_06275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWT12_06290	COG0436	Aminotransferase
CWT12_06315	COG1027	Aspartate ammonia-lyase
CWT12_06325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWT12_06355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CWT12_06425	COG1388	LysM domain
CWT12_06425	COG0791	NLP P60 protein
CWT12_06630	COG0358	DNA primase activity
CWT12_06655	COG3833	ABC-type maltose transport systems, permease component
CWT12_06665	COG1609	Transcriptional regulator
CWT12_06675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CWT12_06685	COG0667	Aldo Keto reductase
CWT12_06690	COG0167	dihydroorotate dehydrogenase activity
CWT12_06710	COG0789	Transcriptional regulator
CWT12_06715	COG1131	(ABC) transporter
CWT12_06725	COG2151	metal-sulfur cluster biosynthetic enzyme
CWT12_06730	COG0822	iron-sulfur transferase activity
CWT12_06740	COG0396	ATPase activity
CWT12_06745	COG0719	Fe-S assembly protein
CWT12_06765	COG0395	ABC-type sugar transport system, permease component
CWT12_06810	COG0351	phosphomethylpyrimidine kinase
CWT12_06820	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CWT12_06825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWT12_06835	COG2815	serine threonine protein kinase
CWT12_06835	COG0515	serine threonine protein kinase
CWT12_06840	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CWT12_06845	COG0205	6-phosphofructokinase activity
CWT12_06860	COG2026	Addiction module toxin, RelE StbE family
CWT12_06865	COG2161	toxin-antitoxin pair type II binding
CWT12_06910	COG0488	(ABC) transporter
CWT12_06955	COG1119	ATPase activity
CWT12_06965	COG0297	glycogen (starch) synthase activity
CWT12_06975	COG0560	Phosphoserine phosphatase
CWT12_07005	COG0423	glycine-tRNA ligase activity
CWT12_07015	COG1116	anion transmembrane transporter activity
CWT12_07020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CWT12_07030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWT12_07035	COG1381	Involved in DNA repair and RecF pathway recombination
CWT12_07040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWT12_07055	COG1476	TRANSCRIPTIONal
CWT12_07060	COG3609	addiction module antidote protein, CC2985 family
CWT12_07065	COG2337	Toxic component of a toxin-antitoxin (TA) module
CWT12_07070	COG1131	(ABC) transporter
CWT12_07085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWT12_07095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CWT12_07115	COG1309	transcriptional regulator
CWT12_07135	COG0484	heat shock protein binding
CWT12_07140	COG1420	regulation of RNA biosynthetic process
CWT12_07165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CWT12_07175	COG0481	GTPase activity
CWT12_07195	COG1216	Glycosyl transferase, family 2
CWT12_07205	COG1472	Belongs to the glycosyl hydrolase 3 family
CWT12_07225	COG0133	tryptophan synthase activity
CWT12_07235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CWT12_07240	COG0512	Glutamine amidotransferase of anthranilate synthase
CWT12_07255	COG0159	tryptophan synthase activity
CWT12_07265	COG2855	membrane
CWT12_07285	COG0268	Binds directly to 16S ribosomal RNA
CWT12_07290	COG4868	Belongs to the UPF0371 family
CWT12_07305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWT12_07305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CWT12_07310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWT12_07325	COG1555	photosystem II stabilization
CWT12_07340	COG0433	COG0433 Predicted ATPase
CWT12_07425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CWT12_07430	COG2094	Belongs to the DNA glycosylase MPG family
CWT12_07435	COG0165	Argininosuccinate lyase
CWT12_07445	COG0137	argininosuccinate synthase activity
CWT12_07450	COG1438	arginine binding
CWT12_07460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWT12_07470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CWT12_07485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CWT12_07495	COG1131	(ABC) transporter
CWT12_07535	COG0765	amino acid transport
CWT12_07560	COG2801	Transposase and inactivated derivatives
CWT12_07570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWT12_07575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWT12_07580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWT12_07585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CWT12_07595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWT12_07600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CWT12_07630	COG2885	chlorophyll binding
CWT12_07660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CWT12_07675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWT12_07700	COG2501	S4 domain
CWT12_07710	COG0587	DNA-directed DNA polymerase activity
CWT12_07725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWT12_07730	COG3599	regulation of cell shape
CWT12_07745	COG1799	cell septum assembly
CWT12_07755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWT12_07765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWT12_07780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CWT12_07795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWT12_07800	COG0768	penicillin binding
CWT12_07810	COG0275	rRNA processing
CWT12_07815	COG2001	Belongs to the MraZ family
CWT12_07825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CWT12_07845	COG0318	PFAM AMP-dependent synthetase and ligase
CWT12_07850	COG0318	PFAM AMP-dependent synthetase and ligase
CWT12_07855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWT12_07865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CWT12_07885	COG0612	Peptidase, M16
CWT12_07890	COG1185	polyribonucleotide nucleotidyltransferase activity
CWT12_07910	COG0196	riboflavin kinase activity
CWT12_07915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CWT12_07920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CWT12_07930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CWT12_07940	COG0195	Participates in both transcription termination and antitermination
CWT12_07945	COG0779	Required for maturation of 30S ribosomal subunits
CWT12_07965	COG0442	prolyl-tRNA aminoacylation
CWT12_07985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CWT12_07990	COG0750	zinc metalloprotease
CWT12_07995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CWT12_08005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CWT12_08015	COG0233	cytoplasmic translational termination
CWT12_08025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CWT12_08030	COG0052	Belongs to the universal ribosomal protein uS2 family
CWT12_08045	COG1131	(ABC) transporter
CWT12_08055	COG2801	Transposase and inactivated derivatives
CWT12_08075	COG0792	nuclease activity
CWT12_08085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWT12_08090	COG0681	Belongs to the peptidase S26 family
CWT12_08105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CWT12_08110	COG1837	Belongs to the UPF0109 family
CWT12_08145	COG1196	nuclear chromosome segregation
CWT12_08150	COG4152	abc transporter atp-binding protein
CWT12_08160	COG0105	UTP biosynthetic process
CWT12_08165	COG0285	dihydrofolate synthase activity
CWT12_08185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWT12_08205	COG0438	transferase activity, transferring glycosyl groups
CWT12_08220	COG1215	transferase activity, transferring glycosyl groups
CWT12_08235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CWT12_08240	COG0175	sulfate reduction
CWT12_08255	COG1648	precorrin-2 dehydrogenase activity
CWT12_08255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CWT12_08260	COG0730	response to heat
CWT12_08270	COG2188	Transcriptional regulator
CWT12_08275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CWT12_08275	COG2190	(PTS) system
CWT12_08275	COG1263	PTS System
CWT12_08280	COG0366	Alpha amylase catalytic
CWT12_08290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWT12_08295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CWT12_08310	COG0438	transferase activity, transferring glycosyl groups
CWT12_08325	COG1086	Polysaccharide biosynthesis protein
CWT12_08330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWT12_08365	COG1131	(ABC) transporter
CWT12_08380	COG1605	Chorismate mutase
CWT12_08380	COG0287	Prephenate dehydrogenase
CWT12_08390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWT12_08395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CWT12_08435	COG3470	protein probably involved in high-affinity Fe2 transport
CWT12_08440	COG0672	)-iron permease
CWT12_08450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWT12_08460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWT12_08465	COG1126	abc transporter atp-binding protein
CWT12_08470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWT12_08475	COG0765	amino acid transport
CWT12_08480	COG0765	amino acid transport
CWT12_08485	COG1252	NADH dehydrogenase
CWT12_08495	COG2137	regulation of response to DNA damage stimulus
CWT12_08500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CWT12_08510	COG1396	sequence-specific DNA binding
CWT12_08515	COG1058	Belongs to the CinA family
CWT12_08515	COG1546	Belongs to the CinA family
CWT12_08525	COG1674	ftsk spoiiie
CWT12_08535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CWT12_08575	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWT12_08580	COG1115	amino acid carrier protein
CWT12_08585	COG1115	amino acid carrier protein
CWT12_08590	COG1115	amino acid carrier protein
CWT12_08605	COG3304	Inner membrane component domain
CWT12_08645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CWT12_08665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CWT12_08675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CWT12_08695	COG0363	glucosamine-6-phosphate deaminase activity
CWT12_08715	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CWT12_08720	COG1940	carbohydrate kinase activity
CWT12_08725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWT12_08735	COG0444	Belongs to the ABC transporter superfamily
CWT12_08745	COG0747	negative chemotaxis
CWT12_08770	COG2249	NAD(P)H dehydrogenase (quinone) activity
CWT12_08790	COG0667	Aldo Keto reductase
CWT12_08810	COG2884	Cell division ATP-binding protein ftsE
CWT12_08835	COG1131	(ABC) transporter
CWT12_08835	COG1716	ATPase activity
CWT12_08835	COG0842	Transport permease protein
CWT12_08850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CWT12_08860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWT12_08875	COG1086	Polysaccharide biosynthesis protein
CWT12_08880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWT12_08890	COG0438	transferase activity, transferring glycosyl groups
CWT12_08910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWT12_08915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWT12_08930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWT12_08955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CWT12_08960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CWT12_08970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWT12_08975	COG0473	3-isopropylmalate dehydrogenase activity
CWT12_08985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWT12_08995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CWT12_09010	COG0569	domain protein
CWT12_09010	COG2985	domain, Protein
CWT12_09020	COG1468	defense response to virus
CWT12_09020	COG1518	maintenance of DNA repeat elements
CWT12_09050	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWT12_09065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CWT12_09085	COG0420	3'-5' exonuclease activity
CWT12_09090	COG0419	ATPase involved in DNA repair
CWT12_09130	COG0653	protein targeting
CWT12_09140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWT12_09145	COG5401	PFAM Sporulation and spore germination
CWT12_09150	COG5002	protein histidine kinase activity
CWT12_09150	COG5000	phosphorelay sensor kinase activity
CWT12_09155	COG0745	RESPONSE REGULATOR receiver
CWT12_09170	COG0714	Associated with various cellular activities
CWT12_09220	COG1482	cell wall glycoprotein biosynthetic process
CWT12_09240	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CWT12_09255	COG3754	Rhamnan synthesis protein F
CWT12_09420	COG1316	TRANSCRIPTIONal
CWT12_09430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWT12_09475	COG0424	maF-like protein
CWT12_09485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWT12_09510	COG0501	Belongs to the peptidase M48B family
CWT12_09540	COG1007	ATP synthesis coupled electron transport
CWT12_09550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWT12_09555	COG0713	ATP synthesis coupled electron transport
CWT12_09560	COG0839	Belongs to the complex I subunit 6 family
CWT12_09570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CWT12_09575	COG1034	ATP synthesis coupled electron transport
CWT12_09580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CWT12_09590	COG0649	NAD binding
CWT12_09595	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWT12_09600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWT12_09610	COG0644	oxidoreductase
CWT12_09615	COG2226	methyltransferase
CWT12_09620	COG1169	isochorismate synthase
CWT12_09640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CWT12_09650	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CWT12_09655	COG1028	Short-chain dehydrogenase reductase Sdr
CWT12_09655	COG3347	Dehydrogenase
CWT12_09665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWT12_09670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CWT12_09675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CWT12_09680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CWT12_09695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWT12_09700	COG0356	it plays a direct role in the translocation of protons across the membrane
CWT12_09710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWT12_09725	COG2197	response regulator
CWT12_09755	COG1136	(ABC) transporter
CWT12_09755	COG0577	efflux transmembrane transporter activity
CWT12_09770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWT12_09805	COG0583	DNA-binding transcription factor activity
CWT12_09815	COG0656	L-ascorbic acid biosynthetic process
CWT12_09830	COG1028	Short-chain dehydrogenase reductase Sdr
CWT12_09845	COG1131	(ABC) transporter
CWT12_09875	COG1129	ABC transporter
CWT12_09880	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWT12_09895	COG0667	Aldo Keto reductase
CWT12_09925	COG1309	transcriptional regulator
CWT12_09935	COG3177	Filamentation induced by cAMP protein fic
CWT12_09940	COG0519	Catalyzes the synthesis of GMP from XMP
CWT12_09975	COG0673	inositol 2-dehydrogenase activity
CWT12_09990	COG1063	alcohol dehydrogenase
CWT12_10000	COG2814	Major facilitator Superfamily
CWT12_10005	COG2814	Major facilitator Superfamily
CWT12_10010	COG1082	Xylose isomerase domain protein TIM barrel
CWT12_10015	COG0673	inositol 2-dehydrogenase activity
CWT12_10030	COG3962	Belongs to the TPP enzyme family
CWT12_10035	COG3718	enzyme involved in inositol metabolism
CWT12_10055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CWT12_10060	COG0673	inositol 2-dehydrogenase activity
CWT12_10085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWT12_10090	COG0328	RNA-DNA hybrid ribonuclease activity
CWT12_10095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWT12_10105	COG0395	ABC-type sugar transport system, permease component
CWT12_10120	COG0516	GMP reductase activity
CWT12_10135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWT12_10140	COG2949	membrane
CWT12_10150	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CWT12_10155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CWT12_10165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWT12_10185	COG1214	PFAM Peptidase M22, glycoprotease
CWT12_10185	COG0456	acetyltransferase
CWT12_10190	COG0802	atpase or kinase
CWT12_10195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWT12_10215	COG4585	Histidine kinase
CWT12_10220	COG2197	response regulator
CWT12_10230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CWT12_10235	COG1072	(Pantothenic acid kinase))
CWT12_10250	COG1733	regulation of RNA biosynthetic process
CWT12_10255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CWT12_10260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CWT12_10285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CWT12_10290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWT12_10295	COG0101	tRNA pseudouridine synthase activity
CWT12_10300	COG1940	carbohydrate kinase activity
CWT12_10305	COG0203	ribosomal protein L17
CWT12_10310	COG0202	RNA polymerase activity
CWT12_10320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWT12_10325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWT12_10330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWT12_10340	COG0563	adenylate kinase activity
CWT12_10350	COG0200	Binds to the 23S rRNA
CWT12_10360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWT12_10365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWT12_10370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CWT12_10375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWT12_10380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWT12_10385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWT12_10390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWT12_10395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWT12_10405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWT12_10410	COG0255	Belongs to the universal ribosomal protein uL29 family
CWT12_10415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWT12_10420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWT12_10425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWT12_10435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWT12_10440	COG0089	rRNA binding
CWT12_10445	COG0088	Forms part of the polypeptide exit tunnel
CWT12_10450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWT12_10455	COG0051	transcription antitermination factor activity, RNA binding
CWT12_10460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWT12_10465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CWT12_10470	COG0049	tRNA binding
CWT12_10475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWT12_10495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CWT12_10505	COG1100	Small GTP-binding protein
CWT12_10575	COG0085	RNA polymerase activity
CWT12_10585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWT12_10590	COG2885	chlorophyll binding
CWT12_10605	COG0515	serine threonine protein kinase
CWT12_10610	COG0081	regulation of translation
CWT12_10615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CWT12_10620	COG0250	Participates in transcription elongation, termination and antitermination
CWT12_10635	COG0436	Aminotransferase
CWT12_10660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CWT12_10665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CWT12_10685	COG0395	ABC-type sugar transport system, permease component
CWT12_10690	COG3507	Belongs to the glycosyl hydrolase 43 family
CWT12_10715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CWT12_10750	COG0395	ABC-type sugar transport system, permease component
CWT12_10755	COG1175	transmembrane transport
CWT12_10765	COG3458	cephalosporin-C deacetylase activity
CWT12_10775	COG4214	carbohydrate transport
CWT12_10785	COG4213	ABC transporter substrate-binding protein
CWT12_10790	COG1609	Transcriptional regulator
CWT12_10795	COG2017	converts alpha-aldose to the beta-anomer
CWT12_10805	COG1609	Transcriptional regulator
CWT12_10815	COG2160	L-arabinose isomerase activity
CWT12_10840	COG2211	Major facilitator Superfamily
CWT12_10850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWT12_10860	COG1733	regulation of RNA biosynthetic process
CWT12_10880	COG0395	ABC-type sugar transport system, permease component
CWT12_10890	COG1609	Transcriptional regulator
CWT12_10895	COG4214	carbohydrate transport
CWT12_10940	COG1070	Carbohydrate kinase
CWT12_10945	COG2115	Belongs to the xylose isomerase family
CWT12_10950	COG1940	carbohydrate kinase activity
CWT12_10950	COG1846	Transcriptional regulator
CWT12_10965	COG0667	Aldo Keto reductase
CWT12_10970	COG2376	Dihydroxyacetone kinase
CWT12_10975	COG2376	Dihydroxyacetone kinase
CWT12_10985	COG3775	system Galactitol-specific IIC component
CWT12_11060	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CWT12_11070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CWT12_11080	COG0247	lactate metabolic process
CWT12_11095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CWT12_11100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CWT12_11105	COG1620	l-lactate permease
CWT12_11115	COG0247	lactate metabolic process
CWT12_11120	COG1139	Iron-sulfur cluster binding protein
CWT12_11125	COG1556	Lactate utilization protein
CWT12_11180	COG1136	(ABC) transporter
CWT12_11205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CWT12_11220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWT12_11235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CWT12_11240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CWT12_11245	COG0302	gtp cyclohydrolase
CWT12_11250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWT12_11315	COG1518	maintenance of DNA repeat elements
CWT12_11315	COG1468	defense response to virus
CWT12_11350	COG2027	D-alanyl-D-alanine carboxypeptidase
CWT12_11355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CWT12_11360	COG0791	NLP P60 protein
CWT12_11360	COG3883	PFAM NLP P60 protein
CWT12_11365	COG2873	o-acetylhomoserine
CWT12_11370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWT12_11390	COG0714	Associated with various cellular activities
CWT12_11415	COG0574	Belongs to the PEP-utilizing enzyme family
CWT12_11415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWT12_11455	COG1490	D-aminoacyl-tRNA deacylase activity
CWT12_11465	COG0738	Major facilitator superfamily
CWT12_11490	COG3485	protocatechuate 3,4-dioxygenase
CWT12_11505	COG0745	RESPONSE REGULATOR receiver
CWT12_11510	COG2814	Major facilitator Superfamily
CWT12_11520	COG0463	Glycosyl transferase, family 2
CWT12_11530	COG0577	efflux transmembrane transporter activity
CWT12_11530	COG1136	(ABC) transporter
CWT12_11640	COG4691	Plasmid stability protein
CWT12_11750	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CWT12_11760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CWT12_11805	COG0191	fructose-bisphosphate aldolase activity
CWT12_11825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CWT12_11860	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CWT12_11870	COG4221	oxidoreductase activity
CWT12_11885	COG0778	Nitroreductase
CWT12_11890	COG2176	DNA-directed DNA polymerase activity
CWT12_11915	COG0717	Belongs to the dCTP deaminase family
CWT12_11935	COG0494	nUDIX hydrolase
CWT12_11995	COG0631	protein serine/threonine phosphatase activity
CWT12_12010	COG5650	phosphatidylinositol metabolic process
CWT12_12030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CWT12_12035	COG1132	(ABC) transporter
CWT12_12040	COG4988	ABC transporter
CWT12_12050	COG0745	RESPONSE REGULATOR receiver
CWT12_12055	COG2205	protein histidine kinase activity
CWT12_12065	COG0577	efflux transmembrane transporter activity
CWT12_12065	COG1136	(ABC) transporter
CWT12_12070	COG1136	(ABC) transporter
CWT12_12070	COG0577	efflux transmembrane transporter activity
CWT12_12125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CWT12_12440	COG3617	BRO family, N-terminal domain
CWT12_12475	COG3842	ATPase activity
CWT12_12505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWT12_12510	COG0215	cysteine-tRNA ligase activity
CWT12_12515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWT12_12520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CWT12_12535	COG0546	phosphoglycolate phosphatase activity
CWT12_12555	COG3059	membrane
CWT12_12565	COG3715	PTS system
CWT12_12585	COG1621	beta-fructofuranosidase activity
CWT12_12585	COG1621	beta-fructofuranosidase activity
CWT12_12635	COG1505	serine-type exopeptidase activity
CWT12_12650	COG0789	Transcriptional regulator
CWT12_12655	COG0484	heat shock protein binding
CWT12_12660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWT12_12665	COG0443	Heat shock 70 kDa protein
CWT12_12670	COG0667	Aldo Keto reductase
CWT12_12675	COG0596	Alpha beta hydrolase
CWT12_12700	COG1597	lipid kinase activity
CWT12_12750	COG0577	efflux transmembrane transporter activity
CWT12_12750	COG1136	(ABC) transporter
CWT12_12770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CWT12_12775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CWT12_12785	COG0181	hydroxymethylbilane synthase activity
CWT12_12795	COG0113	porphobilinogen synthase activity
CWT12_12800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CWT12_12815	COG0783	Belongs to the Dps family
CWT12_12820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWT12_12830	COG1309	transcriptional regulator
CWT12_12840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWT12_12890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CWT12_12965	COG2233	PERMEase
CWT12_12995	COG1733	regulation of RNA biosynthetic process
CWT12_13005	COG0351	phosphomethylpyrimidine kinase
CWT12_13010	COG0305	Participates in initiation and elongation during chromosome replication
CWT12_13015	COG0534	Mate efflux family protein
CWT12_13020	COG0359	binds to the 23S rRNA
CWT12_13025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWT12_13035	COG0360	Binds together with S18 to 16S ribosomal RNA
CWT12_13040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWT12_13045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CWT12_13060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWT12_13070	COG2211	Major facilitator Superfamily
CWT12_13090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWT12_13095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CWT12_13170	COG3118	belongs to the thioredoxin family
CWT12_13175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWT12_13180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWT12_13185	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWT12_13195	COG1192	Involved in chromosome partitioning
CWT12_13200	COG0357	Ribosomal RNA small subunit methyltransferase G
CWT12_13210	COG0706	membrane insertase activity
CWT12_13215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWT12_13220	COG0594	ribonuclease P activity
CWT12_13225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWT12_13230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWT12_13235	COG0592	DNA-directed DNA polymerase activity
CWT12_13240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP