locus-tag	class	description
MANAM107_00030	COG0667	Aldo Keto reductase
MANAM107_00040	COG2807	transmembrane transport
MANAM107_00050	COG0167	dihydroorotate dehydrogenase activity
MANAM107_00080	COG1131	(ABC) transporter
MANAM107_00110	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MANAM107_00120	COG2151	metal-sulfur cluster biosynthetic enzyme
MANAM107_00130	COG0822	iron-sulfur transferase activity
MANAM107_00150	COG0396	ATPase activity
MANAM107_00170	COG0719	Fe-S assembly protein
MANAM107_00200	COG0395	ABC-type sugar transport system, permease component
MANAM107_00230	COG1609	Transcriptional regulator
MANAM107_00300	COG0497	DNA recombination
MANAM107_00310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MANAM107_00330	COG0647	UMP catabolic process
MANAM107_00350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MANAM107_00380	COG1846	Transcriptional regulator
MANAM107_00400	COG2094	Belongs to the DNA glycosylase MPG family
MANAM107_00410	COG0165	Argininosuccinate lyase
MANAM107_00430	COG0137	argininosuccinate synthase activity
MANAM107_00440	COG1438	arginine binding
MANAM107_00450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MANAM107_00460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MANAM107_00480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MANAM107_00510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MANAM107_00520	COG0765	amino acid transport
MANAM107_00530	COG0765	amino acid transport
MANAM107_00540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MANAM107_00550	COG1126	abc transporter atp-binding protein
MANAM107_00610	COG2826	transposase and inactivated derivatives, IS30 family
MANAM107_00660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MANAM107_00670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MANAM107_00680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MANAM107_00690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MANAM107_00710	COG4133	protoheme IX ABC transporter activity
MANAM107_00740	COG0575	Belongs to the CDS family
MANAM107_00760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MANAM107_00770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MANAM107_00800	COG0131	Imidazoleglycerol-phosphate dehydratase
MANAM107_00810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MANAM107_00830	COG0514	ATP-dependent DNA helicase (RecQ)
MANAM107_00860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MANAM107_00880	COG0463	Glycosyl transferase, family 2
MANAM107_00900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MANAM107_00920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MANAM107_00970	COG2501	S4 domain
MANAM107_00980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MANAM107_00990	COG0587	DNA-directed DNA polymerase activity
MANAM107_01020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MANAM107_01030	COG3599	regulation of cell shape
MANAM107_01050	COG1799	cell septum assembly
MANAM107_01060	COG1496	oxidoreductase activity
MANAM107_01090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MANAM107_01120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MANAM107_01130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MANAM107_01140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MANAM107_01150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MANAM107_01160	COG0768	penicillin binding
MANAM107_01180	COG0275	rRNA processing
MANAM107_01190	COG2001	Belongs to the MraZ family
MANAM107_01210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MANAM107_01260	COG0318	PFAM AMP-dependent synthetase and ligase
MANAM107_01290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MANAM107_01300	COG0657	acetylesterase activity
MANAM107_01340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MANAM107_01350	COG0612	Peptidase, M16
MANAM107_01370	COG1185	polyribonucleotide nucleotidyltransferase activity
MANAM107_01420	COG2814	Major facilitator Superfamily
MANAM107_01440	COG0577	efflux transmembrane transporter activity
MANAM107_01440	COG1136	(ABC) transporter
MANAM107_01460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MANAM107_01470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MANAM107_01490	COG0697	spore germination
MANAM107_01500	COG0583	DNA-binding transcription factor activity
MANAM107_01540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MANAM107_01600	COG0442	prolyl-tRNA aminoacylation
MANAM107_01650	COG2197	response regulator
MANAM107_01720	COG3415	Transposase
MANAM107_01720	COG2801	Transposase and inactivated derivatives
MANAM107_01740	COG0456	acetyltransferase
MANAM107_01750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MANAM107_01770	COG0750	zinc metalloprotease
MANAM107_01780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MANAM107_01800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MANAM107_01820	COG0233	cytoplasmic translational termination
MANAM107_01840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MANAM107_01850	COG0052	Belongs to the universal ribosomal protein uS2 family
MANAM107_01890	COG4974	Belongs to the 'phage' integrase family
MANAM107_01920	COG0792	nuclease activity
MANAM107_01940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MANAM107_01950	COG0681	Belongs to the peptidase S26 family
MANAM107_01970	COG0681	Belongs to the peptidase S26 family
MANAM107_01990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MANAM107_02000	COG1837	Belongs to the UPF0109 family
MANAM107_02010	COG0228	four-way junction DNA binding
MANAM107_02030	COG1131	(ABC) transporter
MANAM107_02050	COG4585	Histidine kinase
MANAM107_02060	COG2197	response regulator
MANAM107_02160	COG0352	thiamine-phosphate diphosphorylase activity
MANAM107_02170	COG0477	Major facilitator Superfamily
MANAM107_02180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MANAM107_02180	COG0351	phosphomethylpyrimidine kinase
MANAM107_02180	COG0352	thiamine-phosphate diphosphorylase activity
MANAM107_02210	COG1196	nuclear chromosome segregation
MANAM107_02220	COG0105	UTP biosynthetic process
MANAM107_02230	COG2188	Transcriptional regulator
MANAM107_02240	COG1263	PTS System
MANAM107_02240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_02240	COG2190	(PTS) system
MANAM107_02250	COG0366	Alpha amylase catalytic
MANAM107_02260	COG0285	dihydrofolate synthase activity
MANAM107_02270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MANAM107_02340	COG2056	Na+-H+ antiporter family
MANAM107_02350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MANAM107_02380	COG1122	ATPase activity
MANAM107_02400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MANAM107_02430	COG1222	aaa ATPase
MANAM107_02460	COG0366	Alpha amylase catalytic
MANAM107_02490	COG1653	transport
MANAM107_02520	COG0287	Prephenate dehydrogenase
MANAM107_02520	COG1605	Chorismate mutase
MANAM107_02530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MANAM107_02540	COG0740	serine-type endopeptidase activity
MANAM107_02600	COG0544	peptidyl-prolyl cis-trans isomerase activity
MANAM107_02640	COG1739	Uncharacterized protein family UPF0029
MANAM107_02660	COG1045	serine acetyltransferase
MANAM107_02700	COG3590	peptidase
MANAM107_02740	COG1263	PTS System
MANAM107_02740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_02740	COG2190	(PTS) system
MANAM107_02760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_02770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MANAM107_02830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MANAM107_02990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MANAM107_02990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_03020	COG1615	UPF0182 protein
MANAM107_03050	COG3480	Lon protease (S16) C-terminal proteolytic domain
MANAM107_03100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MANAM107_03120	COG0738	Major facilitator superfamily
MANAM107_03130	COG2390	Transcriptional regulator
MANAM107_03150	COG0482	sulfurtransferase activity
MANAM107_03170	COG1131	(ABC) transporter
MANAM107_03180	COG1725	Transcriptional regulator
MANAM107_03210	COG3552	Protein containing von Willebrand factor type A (VWA) domain
MANAM107_03220	COG0714	Associated with various cellular activities
MANAM107_03250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MANAM107_03260	COG2086	electron transfer activity
MANAM107_03300	COG0366	Alpha amylase catalytic
MANAM107_03320	COG3281	Trehalose synthase
MANAM107_03330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MANAM107_03340	COG0058	SHG alpha-glucan phosphorylase activity
MANAM107_03410	COG0395	ABC-type sugar transport system, permease component
MANAM107_03420	COG1175	transmembrane transport
MANAM107_03430	COG1653	transport
MANAM107_03440	COG0039	L-malate dehydrogenase activity
MANAM107_03450	COG4988	ABC transporter
MANAM107_03460	COG1132	(ABC) transporter
MANAM107_03470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MANAM107_03500	COG1136	(ABC) transporter
MANAM107_03550	COG0045	succinate-CoA ligase (ADP-forming) activity
MANAM107_03640	COG0366	Alpha amylase catalytic
MANAM107_03650	COG1501	Belongs to the glycosyl hydrolase 31 family
MANAM107_03660	COG3291	Pkd domain containing protein
MANAM107_03660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MANAM107_03700	COG1733	regulation of RNA biosynthetic process
MANAM107_03740	COG2910	NAD(P)H-binding
MANAM107_03750	COG1733	regulation of RNA biosynthetic process
MANAM107_03800	COG0542	response to heat
MANAM107_03830	COG2267	carboxylic ester hydrolase activity
MANAM107_03950	COG2890	protein-(glutamine-N5) methyltransferase activity
MANAM107_03960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MANAM107_03970	COG0254	rRNA binding
MANAM107_03990	COG0431	NADPH-dependent FMN reductase
MANAM107_04010	COG0083	homoserine kinase activity
MANAM107_04020	COG0460	homoserine dehydrogenase
MANAM107_04050	COG0019	diaminopimelate decarboxylase activity
MANAM107_04060	COG0018	arginyl-trna synthetase
MANAM107_04080	COG4604	ABC transporter, ATP-binding protein
MANAM107_04090	COG4605	iron ion homeostasis
MANAM107_04100	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_04110	COG4607	ABC-type enterochelin transport system periplasmic component
MANAM107_04130	COG0739	heme binding
MANAM107_04170	COG1253	flavin adenine dinucleotide binding
MANAM107_04180	COG0508	dehydrogenase complex catalyzes the overall conversion of
MANAM107_04180	COG0567	Dehydrogenase, E1 component
MANAM107_04210	COG1309	transcriptional regulator
MANAM107_04220	COG1131	(ABC) transporter
MANAM107_04230	COG3559	Exporter of polyketide antibiotics
MANAM107_04240	COG5662	AntiSigma factor
MANAM107_04250	COG1595	DNA-templated transcription, initiation
MANAM107_04270	COG2838	Isocitrate dehydrogenase
MANAM107_04280	COG1105	Belongs to the carbohydrate kinase PfkB family
MANAM107_04290	COG0191	fructose-bisphosphate aldolase activity
MANAM107_04300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MANAM107_04310	COG1162	GTPase activity
MANAM107_04380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MANAM107_04420	COG0315	cyclic pyranopterin monophosphate synthase activity
MANAM107_04440	COG0315	cyclic pyranopterin monophosphate synthase activity
MANAM107_04440	COG0521	Mo-molybdopterin cofactor biosynthetic process
MANAM107_04470	COG1140	nitrate reductase beta subunit
MANAM107_04520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MANAM107_04530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_04540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_04570	COG1120	ATPase activity
MANAM107_04580	COG1063	alcohol dehydrogenase
MANAM107_04620	COG2249	NAD(P)H dehydrogenase (quinone) activity
MANAM107_04670	COG1132	(ABC) transporter
MANAM107_04680	COG1132	(ABC) transporter
MANAM107_04680	COG2375	cellular response to nickel ion
MANAM107_04690	COG0483	inositol monophosphate 1-phosphatase activity
MANAM107_04700	COG1968	undecaprenyl-diphosphatase activity
MANAM107_04720	COG0420	3'-5' exonuclease activity
MANAM107_04730	COG0419	ATPase involved in DNA repair
MANAM107_04810	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_04830	COG0653	protein targeting
MANAM107_04850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MANAM107_04860	COG0823	Involved in the tonB-independent uptake of proteins
MANAM107_04870	COG5000	phosphorelay sensor kinase activity
MANAM107_04870	COG5002	protein histidine kinase activity
MANAM107_04880	COG0745	RESPONSE REGULATOR receiver
MANAM107_04920	COG0714	Associated with various cellular activities
MANAM107_04930	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MANAM107_04960	COG2835	tetraacyldisaccharide 4'-kinase activity
MANAM107_05030	COG1482	cell wall glycoprotein biosynthetic process
MANAM107_05050	COG3475	LICD family
MANAM107_05070	COG1216	Glycosyl transferase, family 2
MANAM107_05080	COG3475	LICD family
MANAM107_05090	COG1216	Glycosyl transferase, family 2
MANAM107_05120	COG0697	spore germination
MANAM107_05150	COG0438	transferase activity, transferring glycosyl groups
MANAM107_05320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MANAM107_05430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MANAM107_05470	COG1316	TRANSCRIPTIONal
MANAM107_05490	COG1316	TRANSCRIPTIONal
MANAM107_05560	COG0586	Pfam SNARE associated Golgi protein
MANAM107_05580	COG5002	protein histidine kinase activity
MANAM107_05590	COG0745	RESPONSE REGULATOR receiver
MANAM107_05620	COG0424	maF-like protein
MANAM107_05660	COG1666	GTP binding
MANAM107_05710	COG0501	Belongs to the peptidase M48B family
MANAM107_05720	COG0686	Belongs to the AlaDH PNT family
MANAM107_05790	COG0142	geranyltranstransferase activity
MANAM107_05800	COG1007	ATP synthesis coupled electron transport
MANAM107_05820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MANAM107_05830	COG0713	ATP synthesis coupled electron transport
MANAM107_05860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MANAM107_05870	COG1034	ATP synthesis coupled electron transport
MANAM107_05880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MANAM107_05900	COG0649	NAD binding
MANAM107_05910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MANAM107_05920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MANAM107_05940	COG0644	oxidoreductase
MANAM107_06090	COG2226	methyltransferase
MANAM107_06110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MANAM107_06120	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MANAM107_06130	COG4948	Mandelate Racemase Muconate Lactonizing
MANAM107_06140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MANAM107_06160	COG1595	DNA-templated transcription, initiation
MANAM107_06190	COG3477	response to acidic pH
MANAM107_06240	COG0406	alpha-ribazole phosphatase activity
MANAM107_06250	COG2171	N-acyltransferase activity
MANAM107_06270	COG1053	succinate dehydrogenase
MANAM107_06370	COG1217	gtp-binding protein TYPA
MANAM107_06430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANAM107_06450	COG2267	carboxylic ester hydrolase activity
MANAM107_06480	COG4667	esterase of the alpha-beta hydrolase superfamily
MANAM107_06500	COG1902	pentaerythritol trinitrate reductase activity
MANAM107_06510	COG3012	SEC-C Motif Domain Protein
MANAM107_06520	COG1362	aminopeptidase activity
MANAM107_06590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MANAM107_06640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_06640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_06660	COG3415	Transposase
MANAM107_06660	COG2801	Transposase and inactivated derivatives
MANAM107_06680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MANAM107_06730	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
MANAM107_06750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MANAM107_06830	COG1201	RNA secondary structure unwinding
MANAM107_06840	COG0210	DNA helicase
MANAM107_06860	COG0228	four-way junction DNA binding
MANAM107_06900	COG3328	transposase activity
MANAM107_06920	COG2801	Transposase and inactivated derivatives
MANAM107_06960	COG0012	GTP binding
MANAM107_06970	COG1322	Protein conserved in bacteria
MANAM107_06980	COG1302	Protein conserved in bacteria
MANAM107_07030	COG1595	DNA-templated transcription, initiation
MANAM107_07060	COG0833	amino acid
MANAM107_07070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MANAM107_07080	COG1570	exodeoxyribonuclease VII activity
MANAM107_07090	COG1722	exodeoxyribonuclease VII activity
MANAM107_07110	COG2249	NAD(P)H dehydrogenase (quinone) activity
MANAM107_07140	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
MANAM107_07160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MANAM107_07180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MANAM107_07190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MANAM107_07220	COG0583	DNA-binding transcription factor activity
MANAM107_07240	COG0431	NADPH-dependent FMN reductase
MANAM107_07250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MANAM107_07280	COG4171	peptide transport system, permease
MANAM107_07300	COG1124	(ABC) transporter
MANAM107_07320	COG0129	dihydroxy-acid dehydratase activity
MANAM107_07410	COG2197	response regulator
MANAM107_07420	COG0193	aminoacyl-tRNA hydrolase activity
MANAM107_07430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MANAM107_07440	COG0710	3-dehydroquinate dehydratase activity
MANAM107_07480	COG2205	protein histidine kinase activity
MANAM107_07490	COG0745	RESPONSE REGULATOR receiver
MANAM107_07530	COG0577	efflux transmembrane transporter activity
MANAM107_07530	COG1136	(ABC) transporter
MANAM107_07540	COG0577	efflux transmembrane transporter activity
MANAM107_07550	COG0148	phosphopyruvate hydratase activity
MANAM107_07570	COG0438	transferase activity, transferring glycosyl groups
MANAM107_07660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MANAM107_07680	COG1309	transcriptional regulator
MANAM107_07780	COG0297	glycogen (starch) synthase activity
MANAM107_07820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MANAM107_07830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_07830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MANAM107_07850	COG0714	Associated with various cellular activities
MANAM107_07930	COG0488	(ABC) transporter
MANAM107_07940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MANAM107_07950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MANAM107_07980	COG0084	hydrolase, TatD family'
MANAM107_07990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MANAM107_08010	COG1335	isochorismatase
MANAM107_08080	COG1297	OPT oligopeptide transporter protein
MANAM107_08110	COG1733	regulation of RNA biosynthetic process
MANAM107_08200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MANAM107_08220	COG1970	mechanosensitive ion channel activity
MANAM107_08260	COG3103	Sh3 type 3 domain protein
MANAM107_08260	COG1388	LysM domain
MANAM107_08260	COG0791	NLP P60 protein
MANAM107_08290	COG2252	PERMEase
MANAM107_08370	COG1842	Phage shock protein A
MANAM107_08390	COG0745	RESPONSE REGULATOR receiver
MANAM107_08400	COG2205	protein histidine kinase activity
MANAM107_08430	COG0459	protein refolding
MANAM107_08450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MANAM107_08470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MANAM107_08480	COG0346	lactoylglutathione lyase activity
MANAM107_08490	COG0215	cysteine-tRNA ligase activity
MANAM107_08550	COG3842	ATPase activity
MANAM107_08680	COG4585	Histidine kinase
MANAM107_08690	COG2197	response regulator
MANAM107_08710	COG1609	Transcriptional regulator
MANAM107_08720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MANAM107_08760	COG0542	response to heat
MANAM107_08800	COG1505	serine-type exopeptidase activity
MANAM107_08860	COG0789	Transcriptional regulator
MANAM107_08870	COG0484	heat shock protein binding
MANAM107_08880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MANAM107_08890	COG0443	Heat shock 70 kDa protein
MANAM107_08930	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MANAM107_08940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_08960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MANAM107_09040	COG2197	response regulator
MANAM107_09070	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
MANAM107_09110	COG1028	Short-chain dehydrogenase reductase Sdr
MANAM107_09160	COG1597	lipid kinase activity
MANAM107_09190	COG0803	Belongs to the bacterial solute-binding protein 9 family
MANAM107_09200	COG1121	(ABC) transporter
MANAM107_09210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_09220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_09230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MANAM107_09230	COG1918	ferrous iron import across plasma membrane
MANAM107_09280	COG3226	Transcriptional regulator
MANAM107_09300	COG0366	Alpha amylase catalytic
MANAM107_09330	COG0783	Belongs to the Dps family
MANAM107_09350	COG1131	(ABC) transporter
MANAM107_09360	COG1309	transcriptional regulator
MANAM107_09410	COG4585	Histidine kinase
MANAM107_09420	COG2197	response regulator
MANAM107_09500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MANAM107_09510	COG0626	cystathionine gamma-synthase activity
MANAM107_09520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MANAM107_09570	COG0745	RESPONSE REGULATOR receiver
MANAM107_09580	COG1840	ABC-type Fe3 transport system, periplasmic component
MANAM107_09600	COG3842	ATPase activity
MANAM107_09650	COG1653	transport
MANAM107_09660	COG0561	phosphatase activity
MANAM107_09670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MANAM107_09740	COG0583	DNA-binding transcription factor activity
MANAM107_09750	COG1597	lipid kinase activity
MANAM107_09770	COG0077	Prephenate dehydratase
MANAM107_09820	COG1228	amidohydrolase
MANAM107_09870	COG1486	melibiose metabolic process
MANAM107_09880	COG1349	DNA-binding transcription factor activity
MANAM107_09890	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_09890	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MANAM107_09910	COG1175	transmembrane transport
MANAM107_09920	COG0395	ABC-type sugar transport system, permease component
MANAM107_09940	COG2249	NAD(P)H dehydrogenase (quinone) activity
MANAM107_09970	COG2801	Transposase and inactivated derivatives
MANAM107_09970	COG3415	Transposase
MANAM107_10080	COG2376	Dihydroxyacetone kinase
MANAM107_10090	COG1063	alcohol dehydrogenase
MANAM107_10110	COG1760	l-serine dehydratase
MANAM107_10160	COG0351	phosphomethylpyrimidine kinase
MANAM107_10180	COG1121	(ABC) transporter
MANAM107_10200	COG1834	amidinotransferase
MANAM107_10210	COG0833	amino acid
MANAM107_10220	COG0305	Participates in initiation and elongation during chromosome replication
MANAM107_10270	COG0359	binds to the 23S rRNA
MANAM107_10280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MANAM107_10300	COG0360	Binds together with S18 to 16S ribosomal RNA
MANAM107_10310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MANAM107_10320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MANAM107_10340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MANAM107_10370	COG1910	domain protein
MANAM107_10410	COG1132	(ABC) transporter
MANAM107_10410	COG2375	cellular response to nickel ion
MANAM107_10420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MANAM107_10430	COG1609	Transcriptional regulator
MANAM107_10460	COG1175	transmembrane transport
MANAM107_10470	COG0395	ABC-type sugar transport system, permease component
MANAM107_10570	COG2197	response regulator
MANAM107_10590	COG1937	Protein conserved in bacteria
MANAM107_10620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MANAM107_10630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MANAM107_10710	COG1063	alcohol dehydrogenase
MANAM107_10740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MANAM107_10750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MANAM107_10760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_10760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MANAM107_10790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_10800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MANAM107_10810	COG1120	ATPase activity
MANAM107_10830	COG0628	permease
MANAM107_10850	COG1854	S-ribosylhomocysteine lyase activity
MANAM107_10880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_10900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MANAM107_10930	COG2855	membrane
MANAM107_10950	COG0583	DNA-binding transcription factor activity
MANAM107_10970	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MANAM107_10990	COG1966	Carbon starvation protein
MANAM107_11010	COG1716	ATPase activity
MANAM107_11020	COG1716	ATPase activity
MANAM107_11050	COG0768	penicillin binding
MANAM107_11060	COG0515	serine threonine protein kinase
MANAM107_11090	COG3764	Sortase (surface protein transpeptidase)
MANAM107_11230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MANAM107_11240	COG0187	DNA topoisomerase II activity
MANAM107_11250	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MANAM107_11260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_11270	COG0592	DNA-directed DNA polymerase activity
MANAM107_11280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MANAM107_11290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MANAM107_11300	COG0594	ribonuclease P activity
MANAM107_11310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MANAM107_11320	COG0706	membrane insertase activity
MANAM107_11340	COG0357	Ribosomal RNA small subunit methyltransferase G
MANAM107_11350	COG1192	Involved in chromosome partitioning
MANAM107_11410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MANAM107_11430	COG3118	belongs to the thioredoxin family
MANAM107_11440	COG0492	ferredoxin-NADP+ reductase activity
MANAM107_11450	COG0728	peptidoglycan biosynthetic process
MANAM107_11480	COG0617	tRNA 3'-terminal CCA addition
MANAM107_11500	COG3345	alpha-galactosidase
MANAM107_11520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MANAM107_11530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MANAM107_11590	COG0549	Belongs to the carbamate kinase family
MANAM107_11600	COG1953	Uracil, thiamine, allantoin
MANAM107_11610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MANAM107_11640	COG3959	Transketolase, thiamine diphosphate binding domain
MANAM107_11650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MANAM107_11670	COG2084	Dehydrogenase
MANAM107_11680	COG3960	tartronate-semialdehyde synthase activity
MANAM107_11690	COG1953	Uracil, thiamine, allantoin
MANAM107_11700	COG3739	integral membrane protein
MANAM107_11730	COG1950	PFAM Membrane protein of
MANAM107_11740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MANAM107_11750	COG0366	Alpha amylase catalytic
MANAM107_11820	COG1780	Probably involved in ribonucleotide reductase function
MANAM107_11830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MANAM107_11870	COG3328	transposase activity
MANAM107_11880	COG2826	transposase and inactivated derivatives, IS30 family
MANAM107_11910	COG3328	transposase activity
MANAM107_12010	COG0471	metal ion transport
MANAM107_12040	COG0477	Major facilitator Superfamily
MANAM107_12050	COG3265	gluconokinase activity
MANAM107_12080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MANAM107_12100	COG3415	Transposase
MANAM107_12100	COG2801	Transposase and inactivated derivatives
MANAM107_12140	COG2211	Major facilitator Superfamily
MANAM107_12160	COG0672	)-iron permease
MANAM107_12180	COG2837	iron assimilation
MANAM107_12210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MANAM107_12230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MANAM107_12240	COG2011	ABC-type metal ion transport system permease component
MANAM107_12250	COG1464	Belongs to the NlpA lipoprotein family
MANAM107_12260	COG1929	Belongs to the glycerate kinase type-1 family
MANAM107_12280	COG5000	phosphorelay sensor kinase activity
MANAM107_12280	COG5002	protein histidine kinase activity
MANAM107_12320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MANAM107_12360	COG2197	response regulator
MANAM107_12380	COG0577	efflux transmembrane transporter activity
MANAM107_12380	COG1136	(ABC) transporter
MANAM107_12410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MANAM107_12420	COG0037	tRNA processing
MANAM107_12420	COG0590	tRNA wobble adenosine to inosine editing
MANAM107_12430	COG1643	Atp-dependent helicase
MANAM107_12480	COG2233	PERMEase
MANAM107_12540	COG3588	fructose-bisphosphate aldolase
MANAM107_12560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MANAM107_12580	COG1131	(ABC) transporter
MANAM107_12590	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_12590	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_12630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MANAM107_12650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MANAM107_12670	COG0113	porphobilinogen synthase activity
MANAM107_12690	COG0181	hydroxymethylbilane synthase activity
MANAM107_12710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MANAM107_12730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MANAM107_12740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MANAM107_12750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MANAM107_12750	COG3253	May function as heme-dependent peroxidase
MANAM107_12770	COG2181	nitrate reductase activity
MANAM107_12770	COG0247	lactate metabolic process
MANAM107_12810	COG3842	ATPase activity
MANAM107_12820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MANAM107_12840	COG4166	transmembrane transport
MANAM107_12920	COG0326	Molecular chaperone. Has ATPase activity
MANAM107_13120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_13120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MANAM107_13130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MANAM107_13220	COG1136	(ABC) transporter
MANAM107_13220	COG0577	efflux transmembrane transporter activity
MANAM107_13260	COG2337	Toxic component of a toxin-antitoxin (TA) module
MANAM107_13300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MANAM107_13350	COG0596	Alpha beta hydrolase
MANAM107_13370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MANAM107_13480	COG2205	protein histidine kinase activity
MANAM107_13490	COG0745	RESPONSE REGULATOR receiver
MANAM107_13520	COG1754	DNA topoisomerase type I activity
MANAM107_13520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MANAM107_13540	COG0745	RESPONSE REGULATOR receiver
MANAM107_13550	COG2205	protein histidine kinase activity
MANAM107_13560	COG2885	chlorophyll binding
MANAM107_13590	COG2188	Transcriptional regulator
MANAM107_13650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MANAM107_13660	COG0470	DNA polymerase III
MANAM107_13690	COG0252	asparaginase activity
MANAM107_13700	COG1113	amino acid transport
MANAM107_13730	COG0588	phosphoglycerate mutase activity
MANAM107_13750	COG5002	protein histidine kinase activity
MANAM107_13760	COG0745	RESPONSE REGULATOR receiver
MANAM107_13780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MANAM107_13820	COG2197	response regulator
MANAM107_13830	COG3591	Belongs to the peptidase S1B family
MANAM107_13890	COG1309	transcriptional regulator
MANAM107_13930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MANAM107_13940	COG1643	Atp-dependent helicase
MANAM107_13980	COG3142	Participates in the control of copper homeostasis
MANAM107_13990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MANAM107_14000	COG2860	membrane
MANAM107_14030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MANAM107_14050	COG5650	phosphatidylinositol metabolic process
MANAM107_14060	COG0745	RESPONSE REGULATOR receiver
MANAM107_14070	COG2205	protein histidine kinase activity
MANAM107_14080	COG0577	efflux transmembrane transporter activity
MANAM107_14080	COG1136	(ABC) transporter
MANAM107_14160	COG0714	Associated with various cellular activities
MANAM107_14280	COG0717	Belongs to the dCTP deaminase family
MANAM107_14300	COG2176	DNA-directed DNA polymerase activity
MANAM107_14350	COG1175	transmembrane transport
MANAM107_14360	COG0395	ABC-type sugar transport system, permease component
MANAM107_14410	COG2801	Transposase and inactivated derivatives
MANAM107_14440	COG2801	Transposase and inactivated derivatives
MANAM107_14520	COG1028	Short-chain dehydrogenase reductase Sdr
MANAM107_14540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MANAM107_14560	COG0191	fructose-bisphosphate aldolase activity
MANAM107_14570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MANAM107_14620	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MANAM107_14640	COG0151	Belongs to the GarS family
MANAM107_14670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MANAM107_14710	COG0047	phosphoribosylformylglycinamidine synthase activity
MANAM107_14720	COG0438	transferase activity, transferring glycosyl groups
MANAM107_14730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MANAM107_14770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MANAM107_14790	COG1349	DNA-binding transcription factor activity
MANAM107_14810	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MANAM107_14810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MANAM107_14810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MANAM107_14830	COG0557	exoribonuclease II activity
MANAM107_14850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MANAM107_14910	COG1132	(ABC) transporter
MANAM107_14920	COG1132	(ABC) transporter
MANAM107_14930	COG0577	efflux transmembrane transporter activity
MANAM107_14940	COG1136	(ABC) transporter
MANAM107_14960	COG1472	Belongs to the glycosyl hydrolase 3 family
MANAM107_15020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MANAM107_15060	COG0513	Belongs to the DEAD box helicase family
MANAM107_15070	COG2261	transglycosylase associated protein
MANAM107_15100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MANAM107_15170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MANAM107_15200	COG0745	RESPONSE REGULATOR receiver
MANAM107_15220	COG3485	protocatechuate 3,4-dioxygenase
MANAM107_15230	COG0354	folic acid binding
MANAM107_15250	COG1490	D-aminoacyl-tRNA deacylase activity
MANAM107_15310	COG4585	Histidine kinase
MANAM107_15320	COG2197	response regulator
MANAM107_15330	COG4585	Histidine kinase
MANAM107_15350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MANAM107_15390	COG0438	transferase activity, transferring glycosyl groups
MANAM107_15390	COG0297	glycogen (starch) synthase activity
MANAM107_15410	COG0574	Belongs to the PEP-utilizing enzyme family
MANAM107_15410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MANAM107_15420	COG0714	Associated with various cellular activities
MANAM107_15460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MANAM107_15480	COG4585	Histidine kinase
MANAM107_15490	COG2197	response regulator
MANAM107_15520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MANAM107_15530	COG2873	o-acetylhomoserine
MANAM107_15550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MANAM107_15580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MANAM107_15600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MANAM107_15610	COG0302	gtp cyclohydrolase
MANAM107_15630	COG2197	response regulator
MANAM107_15640	COG0577	efflux transmembrane transporter activity
MANAM107_15650	COG1136	(ABC) transporter
MANAM107_15660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MANAM107_15670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MANAM107_15730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MANAM107_15740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MANAM107_15760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MANAM107_15790	COG3104	oligopeptide transport
MANAM107_15810	COG1556	Lactate utilization protein
MANAM107_15820	COG1139	Iron-sulfur cluster binding protein
MANAM107_15840	COG1620	l-lactate permease
MANAM107_15860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MANAM107_15870	COG0698	ribose 5-phosphate isomerase
MANAM107_15900	COG1069	ribulokinase activity
MANAM107_15920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MANAM107_15960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MANAM107_15990	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MANAM107_16050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MANAM107_16080	COG0477	Major facilitator Superfamily
MANAM107_16160	COG2376	Dihydroxyacetone kinase
MANAM107_16170	COG1461	Dihydroxyacetone kinase
MANAM107_16180	COG2017	converts alpha-aldose to the beta-anomer
MANAM107_16220	COG3250	beta-galactosidase activity
MANAM107_16230	COG0569	domain protein
MANAM107_16240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MANAM107_16270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MANAM107_16290	COG0483	inositol monophosphate 1-phosphatase activity
MANAM107_16300	COG1609	Transcriptional regulator
MANAM107_16310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MANAM107_16330	COG1115	amino acid carrier protein
MANAM107_16350	COG0436	Aminotransferase
MANAM107_16390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MANAM107_16400	COG0250	Participates in transcription elongation, termination and antitermination
MANAM107_16410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MANAM107_16420	COG0081	regulation of translation
MANAM107_16440	COG2885	chlorophyll binding
MANAM107_16460	COG2885	chlorophyll binding
MANAM107_16490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MANAM107_16500	COG0222	ribosome binding
MANAM107_16530	COG0085	RNA polymerase activity
MANAM107_16540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MANAM107_16560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MANAM107_16570	COG0049	tRNA binding
MANAM107_16580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MANAM107_16590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MANAM107_16640	COG0051	transcription antitermination factor activity, RNA binding
MANAM107_16660	COG0088	Forms part of the polypeptide exit tunnel
MANAM107_16670	COG0089	rRNA binding
MANAM107_16680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MANAM107_16690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MANAM107_16700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MANAM107_16710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MANAM107_16720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MANAM107_16730	COG0255	Belongs to the universal ribosomal protein uL29 family
MANAM107_16740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MANAM107_16750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MANAM107_16760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MANAM107_16770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MANAM107_16780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MANAM107_16800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MANAM107_16810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MANAM107_16820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MANAM107_16830	COG1841	ribosomal large subunit assembly
MANAM107_16860	COG0563	adenylate kinase activity
MANAM107_16870	COG0024	Methionine aminopeptidase
MANAM107_16890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MANAM107_16900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MANAM107_16910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MANAM107_16920	COG0202	RNA polymerase activity
MANAM107_16930	COG0203	ribosomal protein L17
MANAM107_16950	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MANAM107_16960	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MANAM107_16980	COG0101	tRNA pseudouridine synthase activity
MANAM107_16990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MANAM107_17000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MANAM107_17030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MANAM107_17040	COG1072	(Pantothenic acid kinase))
MANAM107_17050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MANAM107_17060	COG0736	holo-[acyl-carrier-protein] synthase activity
MANAM107_17070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MANAM107_17080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MANAM107_17090	COG0802	atpase or kinase
MANAM107_17140	COG1053	succinate dehydrogenase
MANAM107_17150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MANAM107_17160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MANAM107_17200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MANAM107_17220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MANAM107_17260	COG0516	GMP reductase activity
MANAM107_17270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MANAM107_17300	COG0328	RNA-DNA hybrid ribonuclease activity
MANAM107_17320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MANAM107_17390	COG1082	Xylose isomerase domain protein TIM barrel
MANAM107_17400	COG2814	Major facilitator Superfamily
MANAM107_17410	COG0673	inositol 2-dehydrogenase activity
MANAM107_17420	COG1609	Transcriptional regulator
MANAM107_17450	COG0673	inositol 2-dehydrogenase activity
MANAM107_17460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MANAM107_17470	COG2188	Transcriptional regulator
MANAM107_17480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MANAM107_17500	COG3718	enzyme involved in inositol metabolism
MANAM107_17510	COG3962	Belongs to the TPP enzyme family
MANAM107_17590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MANAM107_17590	COG0519	Catalyzes the synthesis of GMP from XMP
MANAM107_17630	COG2267	carboxylic ester hydrolase activity
MANAM107_17650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MANAM107_17660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MANAM107_17660	COG1116	anion transmembrane transporter activity
MANAM107_17670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MANAM107_17740	COG2197	response regulator
MANAM107_17770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MANAM107_17790	COG0356	it plays a direct role in the translocation of protons across the membrane
MANAM107_17810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MANAM107_17820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MANAM107_17830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MANAM107_17840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MANAM107_17850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MANAM107_17890	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MANAM107_17940	COG3415	Transposase
MANAM107_17940	COG2801	Transposase and inactivated derivatives
MANAM107_17960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MANAM107_17970	COG0254	rRNA binding
MANAM107_17980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MANAM107_17990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MANAM107_18000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MANAM107_18030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MANAM107_18040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MANAM107_18050	COG1254	Belongs to the acylphosphatase family
MANAM107_18070	COG0577	efflux transmembrane transporter activity
MANAM107_18080	COG0577	efflux transmembrane transporter activity
MANAM107_18080	COG1136	(ABC) transporter
MANAM107_18100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MANAM107_18110	COG1349	DNA-binding transcription factor activity
MANAM107_18120	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MANAM107_18380	COG1744	ABC transporter substrate-binding protein PnrA-like
MANAM107_18390	COG3845	ABC transporter
MANAM107_18400	COG4603	Belongs to the binding-protein-dependent transport system permease family
MANAM107_18410	COG1079	Belongs to the binding-protein-dependent transport system permease family
MANAM107_18480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MANAM107_18500	COG1121	(ABC) transporter
MANAM107_18510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_18520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MANAM107_18550	COG3328	transposase activity
MANAM107_18590	COG1611	Belongs to the LOG family
MANAM107_18620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MANAM107_18650	COG2239	Acts as a magnesium transporter
MANAM107_18670	COG1082	Xylose isomerase domain protein TIM barrel
MANAM107_18680	COG1230	cation diffusion facilitator family transporter
MANAM107_18700	COG0006	proline dipeptidase activity
MANAM107_18710	COG0673	inositol 2-dehydrogenase activity
MANAM107_18730	COG2095	MarC family integral membrane protein
MANAM107_18740	COG0513	Belongs to the DEAD box helicase family
MANAM107_18790	COG0114	fumarate hydratase activity
MANAM107_18800	COG0778	Nitroreductase
MANAM107_18810	COG0346	lactoylglutathione lyase activity
MANAM107_18830	COG1174	glycine betaine transport
MANAM107_18840	COG1174	glycine betaine transport
MANAM107_18870	COG3328	transposase activity
MANAM107_18900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MANAM107_18960	COG1674	ftsk spoiiie
MANAM107_18970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MANAM107_18990	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MANAM107_19000	COG0154	amidase activity
MANAM107_19010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MANAM107_19050	COG2985	domain, Protein
MANAM107_19050	COG0569	domain protein
MANAM107_19080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MANAM107_19090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MANAM107_19110	COG0473	3-isopropylmalate dehydrogenase activity
MANAM107_19120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MANAM107_19130	COG1316	TRANSCRIPTIONal
MANAM107_19140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_19160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MANAM107_19180	COG0438	transferase activity, transferring glycosyl groups
MANAM107_19200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MANAM107_19230	COG1086	Polysaccharide biosynthesis protein
MANAM107_19240	COG0438	transferase activity, transferring glycosyl groups
MANAM107_19250	COG1181	Belongs to the D-alanine--D-alanine ligase family
MANAM107_19270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MANAM107_19290	COG2271	Major facilitator Superfamily
MANAM107_19300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MANAM107_19310	COG0515	serine threonine protein kinase
MANAM107_19320	COG1131	(ABC) transporter
MANAM107_19320	COG0842	Transport permease protein
MANAM107_19320	COG1716	ATPase activity
MANAM107_19460	COG0629	single-stranded DNA binding
MANAM107_19480	COG2884	Cell division ATP-binding protein ftsE
MANAM107_19490	COG2177	Part of the ABC transporter FtsEX involved in
MANAM107_19530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MANAM107_19540	COG2233	PERMEase
MANAM107_19570	COG1175	transmembrane transport
MANAM107_19590	COG2186	Transcriptional regulator
MANAM107_19600	COG0747	negative chemotaxis
MANAM107_19620	COG0601	transmembrane transport
MANAM107_19630	COG0444	Belongs to the ABC transporter superfamily
MANAM107_19640	COG4608	Belongs to the ABC transporter superfamily
MANAM107_19650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MANAM107_19660	COG1940	carbohydrate kinase activity
MANAM107_19670	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MANAM107_19690	COG1131	(ABC) transporter
MANAM107_19710	COG0363	glucosamine-6-phosphate deaminase activity
MANAM107_19750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MANAM107_19770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MANAM107_19780	COG1234	tRNA 3'-trailer cleavage
MANAM107_19800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MANAM107_19810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MANAM107_19870	COG3304	Inner membrane component domain
MANAM107_19880	COG2040	homocysteine
MANAM107_19900	COG1115	amino acid carrier protein
MANAM107_19910	COG1115	amino acid carrier protein
MANAM107_19920	COG1115	amino acid carrier protein
MANAM107_19930	COG1115	amino acid carrier protein
MANAM107_19970	COG0179	Fumarylacetoacetate (FAA) hydrolase
MANAM107_20000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MANAM107_20030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MANAM107_20050	COG1674	ftsk spoiiie
MANAM107_20080	COG1546	Belongs to the CinA family
MANAM107_20080	COG1058	Belongs to the CinA family
MANAM107_20090	COG1396	sequence-specific DNA binding
MANAM107_20110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MANAM107_20120	COG2137	regulation of response to DNA damage stimulus
MANAM107_20130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MANAM107_20150	COG1653	transport
MANAM107_20190	COG1940	carbohydrate kinase activity
MANAM107_20190	COG1846	Transcriptional regulator
MANAM107_20200	COG1252	NADH dehydrogenase
MANAM107_20210	COG0509	glycine decarboxylation via glycine cleavage system
MANAM107_20220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MANAM107_20230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MANAM107_20230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MANAM107_20240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MANAM107_20250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MANAM107_20250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_20290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MANAM107_20300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MANAM107_20310	COG1114	Component of the transport system for branched-chain amino acids
MANAM107_20360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MANAM107_20400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MANAM107_20420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MANAM107_20430	COG0438	transferase activity, transferring glycosyl groups
MANAM107_20460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MANAM107_20470	COG0066	3-isopropylmalate dehydratase activity
MANAM107_20480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MANAM107_20490	COG0204	Acyl-transferase
MANAM107_20500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MANAM107_20520	COG1181	Belongs to the D-alanine--D-alanine ligase family
MANAM107_20550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MANAM107_20560	COG1461	Dihydroxyacetone kinase
MANAM107_20590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MANAM107_20620	COG0571	ribonuclease III activity
MANAM107_20630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MANAM107_20670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MANAM107_20680	COG4988	ABC transporter
MANAM107_20710	COG1294	oxidase, subunit
MANAM107_20720	COG1271	oxidase subunit
MANAM107_20730	COG1530	ribonuclease E activity
MANAM107_20740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MANAM107_20750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MANAM107_20760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MANAM107_20770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MANAM107_20790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MANAM107_20810	COG0745	RESPONSE REGULATOR receiver
MANAM107_20820	COG5002	protein histidine kinase activity
MANAM107_20830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MANAM107_20860	COG1132	(ABC) transporter
MANAM107_20870	COG0438	transferase activity, transferring glycosyl groups
MANAM107_20910	COG1349	DNA-binding transcription factor activity
MANAM107_20930	COG1940	carbohydrate kinase activity
MANAM107_20940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MANAM107_20960	COG0799	negative regulation of ribosome biogenesis
MANAM107_20980	COG4989	oxidoreductase activity
MANAM107_21010	COG0789	Transcriptional regulator
MANAM107_21040	COG0813	purine-nucleoside phosphorylase activity
MANAM107_21050	COG0733	neurotransmitter:sodium symporter activity
MANAM107_21110	COG0537	adenosine 5'-monophosphoramidase activity
MANAM107_21120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MANAM107_21130	COG0495	leucyl-tRNA aminoacylation
MANAM107_21160	COG3547	Transposase (IS116 IS110 IS902 family)
MANAM107_21190	COG3328	transposase activity
MANAM107_21200	COG3328	transposase activity
MANAM107_21210	COG1196	nuclear chromosome segregation
MANAM107_21220	COG0433	COG0433 Predicted ATPase
MANAM107_21250	COG0438	transferase activity, transferring glycosyl groups
MANAM107_21280	COG1307	EDD domain protein, DegV family
MANAM107_21320	COG4868	Belongs to the UPF0371 family
MANAM107_21330	COG0268	Binds directly to 16S ribosomal RNA
MANAM107_21380	COG2814	Major facilitator Superfamily
MANAM107_21380	COG0477	Major facilitator Superfamily
MANAM107_21400	COG0159	tryptophan synthase activity
MANAM107_21430	COG0512	Glutamine amidotransferase of anthranilate synthase
MANAM107_21440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MANAM107_21490	COG0481	GTPase activity
MANAM107_21510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MANAM107_21560	COG1420	regulation of RNA biosynthetic process
MANAM107_21570	COG0484	heat shock protein binding
MANAM107_21620	COG1131	(ABC) transporter
MANAM107_21660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MANAM107_21680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MANAM107_21690	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MANAM107_21690	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MANAM107_21690	COG0506	proline dehydrogenase activity
MANAM107_21700	COG1131	(ABC) transporter
MANAM107_21720	COG1476	TRANSCRIPTIONal
MANAM107_21730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MANAM107_21740	COG1381	Involved in DNA repair and RecF pathway recombination
MANAM107_21750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MANAM107_21770	COG0640	Transcriptional regulator
MANAM107_21790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MANAM107_21800	COG1121	(ABC) transporter
MANAM107_21810	COG0803	Belongs to the bacterial solute-binding protein 9 family
MANAM107_21820	COG0423	glycine-tRNA ligase activity
MANAM107_21860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MANAM107_21880	COG0560	Phosphoserine phosphatase
MANAM107_21900	COG0297	glycogen (starch) synthase activity
MANAM107_21920	COG1119	ATPase activity
MANAM107_21960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MANAM107_21990	COG2326	polyphosphate kinase activity
MANAM107_22000	COG1263	PTS System
MANAM107_22000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_22000	COG2190	(PTS) system
MANAM107_22020	COG0488	(ABC) transporter
MANAM107_22050	COG0545	Peptidyl-prolyl cis-trans isomerase
MANAM107_22170	COG0205	6-phosphofructokinase activity
MANAM107_22180	COG2409	Drug exporters of the RND superfamily
MANAM107_22200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MANAM107_22210	COG0515	serine threonine protein kinase
MANAM107_22210	COG2815	serine threonine protein kinase
MANAM107_22220	COG0142	geranyltranstransferase activity
MANAM107_22230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MANAM107_22280	COG1929	Belongs to the glycerate kinase type-1 family
MANAM107_22300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MANAM107_22400	COG0569	domain protein
MANAM107_22410	COG0531	amino acid
MANAM107_22420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MANAM107_22440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MANAM107_22490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MANAM107_22500	COG4221	oxidoreductase activity
MANAM107_22510	COG1881	PFAM PEBP family protein
MANAM107_22540	COG0671	phosphoesterase, PA-phosphatase related
MANAM107_22550	COG1435	thymidine kinase activity
MANAM107_22590	COG0587	DNA-directed DNA polymerase activity
MANAM107_22640	COG0738	Major facilitator superfamily
MANAM107_22700	COG0667	Aldo Keto reductase
MANAM107_22740	COG0517	IMP dehydrogenase activity
MANAM107_22740	COG1994	Peptidase M50
MANAM107_22750	COG2814	Major facilitator Superfamily
MANAM107_22780	COG1222	aaa ATPase
MANAM107_22790	COG4122	O-methyltransferase activity
MANAM107_22810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MANAM107_22830	COG0107	imidazoleglycerol-phosphate synthase activity
MANAM107_22880	COG0134	indole-3-glycerol-phosphate synthase activity
MANAM107_22890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MANAM107_22940	COG2050	protein possibly involved in aromatic compounds catabolism
MANAM107_22960	COG0539	negative regulation of cytoplasmic translation
MANAM107_22980	COG2076	Multidrug Resistance protein
MANAM107_22990	COG0237	dephospho-CoA kinase activity
MANAM107_23000	COG0556	nucleotide-excision repair
MANAM107_23030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MANAM107_23050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MANAM107_23060	COG3415	Transposase
MANAM107_23060	COG2801	Transposase and inactivated derivatives
MANAM107_23070	COG2226	methyltransferase
MANAM107_23140	COG1882	Formate acetyltransferase
MANAM107_23270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MANAM107_23290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MANAM107_23300	COG1560	Kdo2-lipid A biosynthetic process
MANAM107_23310	COG0438	transferase activity, transferring glycosyl groups
MANAM107_23340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MANAM107_23360	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MANAM107_23370	COG0217	transcriptional regulatory protein
MANAM107_23380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MANAM107_23390	COG0632	four-way junction helicase activity
MANAM107_23400	COG2255	four-way junction helicase activity
MANAM107_23420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MANAM107_23430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MANAM107_23440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MANAM107_23450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MANAM107_23470	COG0789	Transcriptional regulator
MANAM107_23480	COG1196	nuclear chromosome segregation
MANAM107_23500	COG0488	(ABC) transporter
MANAM107_23590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MANAM107_23620	COG0640	Transcriptional regulator
MANAM107_23630	COG0584	glycerophosphoryl diester phosphodiesterase
MANAM107_23640	COG0009	L-threonylcarbamoyladenylate synthase
MANAM107_23650	COG2409	Drug exporters of the RND superfamily
MANAM107_23670	COG0730	response to heat
MANAM107_23680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MANAM107_23690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MANAM107_23700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MANAM107_23730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MANAM107_23760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MANAM107_23770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MANAM107_23820	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MANAM107_23930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MANAM107_23940	COG0540	Belongs to the ATCase OTCase family
MANAM107_23950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MANAM107_23960	COG0284	orotidine-5'-phosphate decarboxylase activity
MANAM107_23980	COG0194	GDP metabolic process
MANAM107_23990	COG1758	RNA polymerase activity
MANAM107_24010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MANAM107_24020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MANAM107_24090	COG1834	amidinotransferase
MANAM107_24100	COG0549	Belongs to the carbamate kinase family
MANAM107_24110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MANAM107_24120	COG2235	arginine
MANAM107_24130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MANAM107_24150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MANAM107_24160	COG4770	biotin carboxylase activity
MANAM107_24170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MANAM107_24180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MANAM107_24210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MANAM107_24220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MANAM107_24230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MANAM107_24240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MANAM107_24250	COG0140	phosphoribosyl-ATP diphosphatase activity
MANAM107_24270	COG1131	(ABC) transporter
MANAM107_24290	COG2197	response regulator
MANAM107_24320	COG3328	transposase activity
MANAM107_24420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MANAM107_24460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MANAM107_24480	COG3022	response to hydroperoxide
MANAM107_24520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MANAM107_24530	COG0174	glutamine synthetase
MANAM107_24540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MANAM107_24560	COG1126	abc transporter atp-binding protein
MANAM107_24570	COG0765	amino acid transport
MANAM107_24580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MANAM107_24610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MANAM107_24620	COG0321	lipoyl(octanoyl) transferase activity
MANAM107_24640	COG0508	dehydrogenase complex catalyzes the overall conversion of
MANAM107_24650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MANAM107_24660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MANAM107_24680	COG0583	DNA-binding transcription factor activity
MANAM107_24690	COG0667	Aldo Keto reductase
MANAM107_24700	COG0322	excinuclease ABC activity
MANAM107_24710	COG3711	transcriptional antiterminator
MANAM107_24730	COG1263	PTS System
MANAM107_24730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_24730	COG2190	(PTS) system
MANAM107_24750	COG1660	Displays ATPase and GTPase activities
MANAM107_24770	COG1481	regulation of sporulation
MANAM107_24780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MANAM107_24800	COG0149	triose-phosphate isomerase activity
MANAM107_24810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MANAM107_24840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MANAM107_24850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MANAM107_24870	COG0287	Prephenate dehydrogenase
MANAM107_24880	COG1160	GTP binding
MANAM107_24940	COG0166	Belongs to the GPI family
MANAM107_24960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MANAM107_25010	COG0662	Cupin 2, conserved barrel domain protein
MANAM107_25030	COG1201	RNA secondary structure unwinding
MANAM107_25140	COG0363	glucosamine-6-phosphate deaminase activity
MANAM107_25170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MANAM107_25190	COG1716	ATPase activity
MANAM107_25220	COG0443	Heat shock 70 kDa protein
MANAM107_25250	COG1621	beta-fructofuranosidase activity
MANAM107_25260	COG1263	PTS System
MANAM107_25260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MANAM107_25260	COG2190	(PTS) system
MANAM107_25270	COG1609	Transcriptional regulator
MANAM107_25290	COG1136	(ABC) transporter
MANAM107_25300	COG0577	efflux transmembrane transporter activity
MANAM107_25330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MANAM107_25340	COG1487	ribonuclease activity
MANAM107_25400	COG0205	6-phosphofructokinase activity
MANAM107_25420	COG1216	Glycosyl transferase, family 2
MANAM107_25440	COG4581	dead DEAH box helicase
MANAM107_25460	COG0805	protein transport
MANAM107_25480	COG2378	regulation of single-species biofilm formation
MANAM107_25500	COG3328	transposase activity
MANAM107_25630	COG2801	Transposase and inactivated derivatives
MANAM107_25630	COG3415	Transposase
MANAM107_25670	COG0542	response to heat
MANAM107_25710	COG3328	transposase activity
MANAM107_25800	COG0730	response to heat
MANAM107_25810	COG0641	radical SAM
MANAM107_25820	COG3119	arylsulfatase activity
MANAM107_25830	COG0395	ABC-type sugar transport system, permease component
MANAM107_25840	COG1175	transmembrane transport
MANAM107_25890	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MANAM107_25910	COG1027	Aspartate ammonia-lyase
MANAM107_25930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MANAM107_25980	COG0358	DNA primase activity
MANAM107_26010	COG2182	Extracellular solute-binding protein
MANAM107_26040	COG3833	ABC-type maltose transport systems, permease component
MANAM107_26060	COG1609	Transcriptional regulator