locus-tag class description BK816_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BK816_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BK816_00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BK816_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BK816_00055 ENOG4107QSI ABC, transporter BK816_00075 ENOG4105ZJT Cell division protein CrgA BK816_00085 ENOG4108RN7 integral membrane protein BK816_00090 ENOG4105D9P serine threonine protein kinase BK816_00095 ENOG4107TPY serine threonine protein kinase BK816_00100 ENOG4105CJN penicillin-binding protein BK816_00115 ENOG4105HZM Fha domain containing protein BK816_00120 ENOG4105TV9 FHA Domain-Containing protein BK816_00130 ENOG41065RQ ADP-ribosylation crystallin J1 BK816_00135 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BK816_00140 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BK816_00145 ENOG4105EJQ L-serine dehydratase BK816_00150 ENOG4107RY6 amino acid BK816_00160 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BK816_00180 ENOG4105BZ1 (ABC) transporter BK816_00220 ENOG4107QHE Choloylglycine hydrolase BK816_00245 ENOG4105BZ1 (ABC) transporter BK816_00250 ENOG4105BZ1 (ABC) transporter BK816_00255 ENOG4105C8J )-transporter BK816_00275 ENOG4105D7W serine acetyltransferase BK816_00280 ENOG4107QMU Mate efflux family protein BK816_00285 ENOG4105CDU Replicative dna helicase BK816_00305 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BK816_00315 ENOG4105DWF phosphomethylpyrimidine kinase BK816_00350 ENOG4105C19 ABC transporter BK816_00385 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BK816_00440 ENOG4107R0E Glycosyl transferase, family 2 BK816_00480 ENOG4105EY8 ABC transporter BK816_00500 ENOG4108IJ1 Dehydrogenase BK816_00510 ENOG4108KGH TRANSCRIPTIONal BK816_00530 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BK816_00545 ENOG41082T9 Membrane BK816_00585 ENOG4107RGJ metallophosphoesterase BK816_00590 ENOG4105BZ4 penicillin-binding protein BK816_00655 ENOG4108I5C dEAD DEAH box helicase BK816_00660 ENOG4105CFH Aspartokinase BK816_00665 ENOG4105D6E homoserine dehydrogenase BK816_00670 ENOG4105D98 threonine synthase BK816_00675 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BK816_00685 ENOG4105C2W permease BK816_00705 ENOG4105C3Q Glycosyl transferase, family 2 BK816_00725 ENOG4105CC5 ABC transporter BK816_00730 ENOG4105DIK (ABC) transporter BK816_00755 ENOG4105CXB phosphoribosylaminoimidazole synthetase BK816_00760 ENOG4105EX0 alpha-galactosidase BK816_00790 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BK816_00800 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BK816_00810 ENOG4105WH1 Two component transcriptional regulator luxr family BK816_00855 ENOG4105BZ1 (ABC) transporter BK816_00860 ENOG4105BZ1 (ABC) transporter BK816_00875 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BK816_00885 ENOG4105CJ1 ABC, transporter BK816_00890 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BK816_00900 ENOG4107QIK phosphoribosylformylglycinamidine synthase BK816_00935 ENOG4105XSJ toxin secretion phage lysis holin BK816_01005 ENOG4105EFC phage portal protein HK97 family BK816_01015 ENOG4105CAR Terminase, large subunit BK816_01045 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BK816_01165 ENOG4105C19 ABC transporter BK816_01225 ENOG4105NTK Transcriptional repressor Mpra BK816_01235 ENOG4108UZX fmn reductase BK816_01240 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BK816_01245 ENOG4105UYK outer membrane protein a BK816_01265 ENOG41079KZ Major Facilitator Superfamily BK816_01270 ENOG4105D2H Uronic isomerase BK816_01275 ENOG4105D82 Glutamate dehydrogenase BK816_01280 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BK816_01285 ENOG4105KZ7 phosphocarrier protein hpr BK816_01295 ENOG41080RH Thioredoxin BK816_01345 ENOG4105C12 Phosphoribosylglycinamide synthetase BK816_01355 ENOG4105C8V SAICAR synthetase BK816_01365 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BK816_01370 ENOG4107TE5 Lipid kinase BK816_01375 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BK816_01380 ENOG410667J hydrolase BK816_01430 ENOG4105C4X radical SAM domain protein BK816_01445 ENOG4105C7N Xanthine uracil vitamin C permease BK816_01450 ENOG4105C54 Major Facilitator superfamily BK816_01455 ENOG4105ETE Transcriptional regulator (LacI family BK816_01470 ENOG4105CJ3 phosphate transporter BK816_01500 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BK816_01510 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BK816_01530 ENOG4105CH6 catalase BK816_01535 ENOG4108PJD permease BK816_01545 ENOG4105G6Z alkaline phosphatase BK816_01550 ENOG4105E2D ec 3.2.1.52 BK816_01560 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BK816_01565 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC BK816_01570 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BK816_01615 ENOG4105C0D helicase BK816_01640 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BK816_01675 ENOG4105E70 isomerase BK816_01685 ENOG4108SU4 UPF0309 protein BK816_01715 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BK816_01725 ENOG4107GBW cellulosome anchoring protein cohesin BK816_01740 ENOG4105DHP deoxycytidine triphosphate deaminase BK816_01750 ENOG4105DF6 Fe-S oxidoreductase BK816_01760 ENOG4105CHF Glutathione S-transferase BK816_01780 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BK816_01790 ENOG4105P52 geranylgeranyl reductase BK816_01800 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BK816_01805 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BK816_01810 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BK816_01820 ENOG4107QIZ NADH dehydrogenase BK816_01825 ENOG4108IEH NADH dehydrogenase subunit g BK816_01830 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BK816_01835 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BK816_01840 ENOG4105DF2 NADH dehydrogenase subunit j BK816_01845 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BK816_01850 ENOG4105D65 subunit l BK816_01860 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BK816_01880 ENOG4105D0M Protease HtpX homolog BK816_01885 ENOG4108VPT UPF0234 protein BK816_01905 ENOG4105WDJ 50S ribosomal protein L33 BK816_01915 ENOG4107R4N Cell wall formation (By similarity) BK816_01920 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BK816_01935 ENOG4105E8V Alpha Beta Hydrolase Fold protein BK816_01960 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BK816_01965 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BK816_01970 ENOG4105ESP cell wall surface anchor family protein BK816_01975 ENOG4108VZM 50s ribosomal protein L10 BK816_01980 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BK816_01985 ENOG4105BZ1 (ABC) transporter BK816_01990 ENOG4108JJ9 ABC, transporter BK816_01995 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BK816_02000 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BK816_02025 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BK816_02030 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BK816_02035 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BK816_02040 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BK816_02045 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BK816_02050 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BK816_02055 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BK816_02060 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BK816_02065 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BK816_02070 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BK816_02080 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BK816_02085 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BK816_02090 ENOG41082SA 50s ribosomal protein l29 BK816_02095 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BK816_02100 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BK816_02105 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BK816_02110 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BK816_02115 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BK816_02120 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BK816_02130 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BK816_02135 ENOG410849U 50S ribosomal protein L30 BK816_02140 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BK816_02150 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BK816_02155 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BK816_02160 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BK816_02165 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BK816_02170 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BK816_02175 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BK816_02180 ENOG4108ZT0 50S ribosomal protein l17 BK816_02185 ENOG41066F8 ROK family BK816_02190 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BK816_02195 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BK816_02200 ENOG4108UJD 30S ribosomal protein S9 BK816_02205 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BK816_02215 ENOG4105CS9 pantothenic acid kinase BK816_02220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BK816_02225 ENOG4108097 ATP-binding protein BK816_02250 ENOG4105E33 succinate dehydrogenase BK816_02255 ENOG4105CAG UPF0210 protein BK816_02280 ENOG4105ECY inositol monophosphatase BK816_02285 ENOG41080R8 Conserved Protein BK816_02290 ENOG4107QR9 Iron-sulfur cluster binding protein BK816_02295 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BK816_02300 ENOG4105DAA L-lactate BK816_02305 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BK816_02355 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BK816_02360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BK816_02365 ENOG4105CVM Molybdenum cofactor synthesis domain protein BK816_02370 ENOG41068WN BK816_02405 ENOG4107GBW cellulosome anchoring protein cohesin BK816_02440 ENOG41082BV acetyltransferase BK816_02450 ENOG4105PGM cation diffusion facilitator family transporter BK816_02460 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BK816_02465 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BK816_02470 ENOG4107GBW cellulosome anchoring protein cohesin BK816_02475 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BK816_02490 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BK816_02500 ENOG4107QVP Dehydrogenase BK816_02505 ENOG4107GFK fumarate BK816_02525 ENOG4105CJW magnesium transporter BK816_02535 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BK816_02540 ENOG4107T6F Xaa-Pro aminopeptidase BK816_02560 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component BK816_02570 ENOG4105EYW Ion transport protein BK816_02575 ENOG4105C1J atp-dependent rna helicase BK816_02595 ENOG4105C4R Atp-dependent dna helicase BK816_02640 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BK816_02650 ENOG4105CAK Cell division ATP-binding protein ftsE BK816_02655 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) BK816_02660 ENOG4105DR5 peptidase BK816_02665 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BK816_02715 ENOG4108426 dNA-binding protein BK816_02720 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BK816_02740 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BK816_02745 ENOG4108RQ5 Beta-lactamase domain-containing protein BK816_02750 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BK816_02755 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BK816_02775 ENOG4105DZ1 carboxypeptidase BK816_02795 ENOG4105DJZ UPF0182 protein BK816_02805 ENOG4105F27 Major Facilitator BK816_02820 ENOG410667J hydrolase BK816_02830 ENOG4105CQ7 ATP-dependent helicase BK816_02840 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BK816_02845 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BK816_02850 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BK816_02880 ENOG4105EC2 ftsk spoIIIe BK816_02885 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BK816_02890 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BK816_02895 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BK816_02900 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BK816_02905 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BK816_02915 ENOG4107QKS N-acylglucosamine 2-epimerase BK816_02940 ENOG4105D0C transport protein BK816_02945 ENOG4105CM2 brancheD-chain amino acid aminotransferase BK816_02970 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BK816_02985 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BK816_03000 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BK816_03005 ENOG4105CPF Cell wall formation (By similarity) BK816_03025 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BK816_03045 ENOG4107YH6 single-stranded DNA-binding protein BK816_03075 ENOG4105CI1 PTS System BK816_03080 ENOG4105FDP GntR family transcriptional regulator BK816_03085 ENOG4105C9K Endothelin-converting enzyme 1 BK816_03090 ENOG4108YZG isomerase BK816_03095 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BK816_03105 ENOG4105EXC Acyl-transferase BK816_03125 ENOG4105EZR dyp-type peroxidase family protein BK816_03135 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BK816_03140 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BK816_03145 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BK816_03150 ENOG4105C93 Xylose Isomerase BK816_03160 ENOG4105C87 Aminotransferase class I and II BK816_03165 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BK816_03170 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BK816_03180 ENOG4105DFM M18 family aminopeptidase BK816_03220 ENOG4105CI3 gtp-binding protein typa BK816_03230 ENOG4108Z4U Ferredoxin BK816_03240 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) BK816_03245 ENOG4107WR6 Maf-like protein BK816_03255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BK816_03260 ENOG4105ECM Sensor protein basS pmrB BK816_03270 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BK816_03275 ENOG4105CMR udp-glucose 4-epimerase BK816_03280 ENOG4108KGH TRANSCRIPTIONal BK816_03285 ENOG4108KGH TRANSCRIPTIONal BK816_03300 ENOG4105J5G Transferase hexapeptide repeat containing protein BK816_03320 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BK816_03350 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BK816_03365 ENOG410602S Transferase BK816_03375 ENOG4105EY8 ABC transporter BK816_03380 ENOG4105K64 Glycosyl transferase, family 2 BK816_03390 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) BK816_03430 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BK816_03435 ENOG4108WQ6 secreted protein BK816_03455 ENOG4105BZU Histidine kinase BK816_03465 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BK816_03470 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea BK816_03515 ENOG4105EYH Exonuclease BK816_03525 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BK816_03530 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BK816_03540 ENOG4105EMN RNA polymerase sigma factor BK816_03550 ENOG4108SHJ s-layer protein BK816_03560 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BK816_03565 ENOG4105C37 (CBS) domain BK816_03575 ENOG4105E4C Lytic transglycosylase catalytic BK816_03580 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BK816_03595 ENOG4105C75 arginyL-tRNA synthetase BK816_03625 ENOG4105VFB Binds the 23S rRNA (By similarity) BK816_03630 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BK816_03635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BK816_03655 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) BK816_03660 ENOG4105ZA1 atp synthase BK816_03670 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BK816_03675 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BK816_03680 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BK816_03685 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BK816_03690 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BK816_03700 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) BK816_03705 ENOG4105CE4 GlcNAc 6-P deacetylase BK816_03735 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BK816_03740 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) BK816_03745 ENOG4105C31 Tryptophanyl-tRNA synthetase BK816_03760 ENOG4105C10 Electron transfer flavoprotein BK816_03770 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BK816_03810 ENOG4105C8T Leucyl-tRNA synthetase BK816_03825 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BK816_03830 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BK816_03835 ENOG4105VE1 Phosphatidylcholine synthase BK816_03845 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BK816_03860 ENOG4105K5M 30s ribosomal protein S16 BK816_03865 ENOG41082KU UPF0109 protein BK816_03870 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BK816_03875 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BK816_03880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BK816_03890 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BK816_03900 ENOG41080R2 UPF0102 protein BK816_03905 ENOG4105C0P Mg chelatase subunit ChlI BK816_03915 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BK816_03930 ENOG4107QN2 dihydrolipoyl dehydrogenase BK816_03940 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BK816_03960 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) BK816_03965 ENOG4105E5F proteasome BK816_03975 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) BK816_03990 ENOG4105CA9 Pyruvate kinase BK816_04015 ENOG4105KA0 thioesterase Superfamily protein BK816_04025 ENOG4108IJ8 ABC transporter BK816_04035 ENOG4105DEI Mannitol dehydrogenase BK816_04040 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BK816_04045 ENOG4108UHU Aldolase BK816_04050 ENOG4105D7K pfkb domain protein BK816_04065 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BK816_04070 ENOG4108JP0 extracellular solute-binding protein family 1 BK816_04085 ENOG4107R13 MMPL domain protein BK816_04095 ENOG4105D22 carbon starvation protein BK816_04100 ENOG4108DBC nitroreductase BK816_04110 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BK816_04130 ENOG4105D17 glycoside hydrolase, family 3 domain protein BK816_04140 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BK816_04155 ENOG4105DHU Bile acid BK816_04170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BK816_04175 ENOG4108IQE Amp-dependent synthetase and ligase BK816_04180 ENOG4105C5F glutamine synthetase BK816_04185 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BK816_04190 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BK816_04195 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BK816_04200 ENOG4105CHW UPF0052 protein BK816_04205 ENOG4105CIE May be required for sporulation (By similarity) BK816_04210 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BK816_04215 ENOG4105BZA Phosphoglycerate kinase BK816_04220 ENOG4105CP7 Triose-phosphate isomerase BK816_04255 ENOG4105C9M aspartyl-trna synthetase BK816_04260 ENOG4107RTD sua5 ycio yrdc ywlc family protein BK816_04275 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BK816_04285 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BK816_04290 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BK816_04300 ENOG4105E2X shikimate dehydrogenase BK816_04310 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BK816_04315 ENOG4105D49 3-dehydroquinate synthase BK816_04325 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BK816_04330 ENOG410803B Involved in the transcription termination process (By similarity) BK816_04335 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BK816_04340 ENOG4105CXT aspartate transcarbamylase BK816_04345 ENOG4105CD3 dihydroorotase BK816_04350 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BK816_04355 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BK816_04360 ENOG4105SKN orotidine 5''-phosphate decarboxylase BK816_04365 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BK816_04370 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BK816_04380 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BK816_04385 ENOG4107RSZ Primosomal protein n' BK816_04390 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BK816_04400 ENOG4105DJV ribulose-phosphate 3-epimerase BK816_04405 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component BK816_04410 ENOG4107XKF NMT1 THI5 Like Domain Protein BK816_04420 ENOG4105CQR helicase BK816_04430 ENOG4105Q70 BK816_04480 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BK816_04485 ENOG4105CAT Cytidine monophosphate kinase BK816_04505 ENOG4105CUT histidyl-tRNA synthetase BK816_04515 ENOG4105C99 atpase involved in dna repair BK816_04520 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BK816_04525 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BK816_04530 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BK816_04535 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BK816_04545 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BK816_04550 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BK816_04555 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BK816_04560 ENOG4105CDY transcriptional regulatory protein BK816_04570 ENOG4105E2K Glycosyl transferase (Group 1 BK816_04590 ENOG4105C22 threonyL-tRNA synthetase BK816_04670 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BK816_04680 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BK816_04685 ENOG4105C0X amino acid BK816_04690 ENOG4107VEG TrkA-N domain protein BK816_04735 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BK816_04750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BK816_04760 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BK816_04775 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase BK816_04830 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BK816_04840 ENOG4105FCS tRNA rRNA methyltransferase BK816_04845 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BK816_04860 ENOG4105DWV Homoserine O-trans-acetylase BK816_04875 ENOG4105D7N magnesium and cobalt transport protein CorA BK816_04880 ENOG4105DPH UPF0371 protein BK816_04890 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BK816_04895 ENOG4105DCF alanine dehydrogenase BK816_04900 ENOG4105C85 amino acid BK816_04910 ENOG4108YYH Nadph-dependent fmn reductase BK816_04935 ENOG4107S6Z Na H antiporter BK816_04940 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein BK816_04955 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BK816_04980 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BK816_04985 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BK816_04990 ENOG4105D2N Aldolase BK816_04995 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) BK816_05000 ENOG4105E98 transcriptional regulator DeoR family BK816_05005 ENOG4105CT8 Phosphorylase BK816_05010 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BK816_05015 ENOG4105K46 50S ribosomal protein l27 BK816_05020 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BK816_05025 ENOG4105C03 ribonuclease BK816_05030 ENOG4105C4M (Ubiquinol oxidase) subunit I BK816_05035 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BK816_05040 ENOG4108JJ9 ABC, transporter BK816_05045 ENOG4108JJ8 (ABC) transporter BK816_05070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BK816_05075 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BK816_05085 ENOG4105FDP GntR family transcriptional regulator BK816_05090 ENOG4105DEF Extracellular solute-binding protein, family 5 BK816_05095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BK816_05105 ENOG4108JQ7 (ABC) transporter BK816_05110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BK816_05115 ENOG4105DKQ ROK family BK816_05120 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BK816_05125 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BK816_05130 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BK816_05150 ENOG4107XFJ UPF0246 protein BK816_05175 ENOG4105EGD dinuclear metal center protein, YbgI family BK816_05190 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BK816_05210 ENOG4105CKU formyltetrahydrofolate synthetase BK816_05215 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BK816_05220 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BK816_05225 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BK816_05230 ENOG4105DZP Membrane-associated zinc metalloprotease BK816_05235 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BK816_05245 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BK816_05250 ENOG4105KNE Phosphatidate cytidylyltransferase BK816_05255 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BK816_05260 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BK816_05265 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BK816_05270 ENOG4105CE9 30S ribosomal protein S2 BK816_05295 ENOG4105C0D helicase BK816_05300 ENOG4107104 thymidine kinase BK816_05315 ENOG4108V1U phospholipid-binding protein BK816_05320 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BK816_05330 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BK816_05360 ENOG4106PMH Extracellular solute-binding protein family 3 BK816_05365 ENOG4105DRP amino acid AbC transporter BK816_05375 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BK816_05380 ENOG4105C5F glutamine synthetase BK816_05395 ENOG4105DKW ABC transporter BK816_05400 ENOG4107QPH glycogen) synthase BK816_05405 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BK816_05420 ENOG4105C5H ABC transporter BK816_05425 ENOG4105CEY Amp-dependent synthetase and ligase BK816_05435 ENOG4105CBD Diacylglycerol kinase BK816_05440 ENOG4105VG1 fes assembly suf system protein BK816_05445 ENOG4108UNV SUF system FeS assembly protein, NifU family BK816_05450 ENOG4105C9B Cysteine desulfurase BK816_05455 ENOG4105C3K feS assembly ATPase SufC BK816_05460 ENOG4105VQD rieske 2fe-2S domain-containing protein BK816_05465 ENOG4105JRK feS assembly protein SufD BK816_05510 ENOG4105DSU hydrolase BK816_05520 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BK816_05525 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BK816_05530 ENOG4105KNH Nucleic acid-binding protein BK816_05540 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BK816_05560 ENOG4105VB9 50S ribosomal protein l28 BK816_05575 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BK816_05580 ENOG4108RWN rrna methyltransferase BK816_05585 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BK816_05590 ENOG41084BS 50S ribosomal protein L35 BK816_05610 ENOG410848D S4 domain protein YaaA BK816_05625 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BK816_05630 ENOG4107VQS DivIVA family BK816_05640 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BK816_05645 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BK816_05650 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BK816_05660 ENOG4105DFU Cell wall formation (By similarity) BK816_05670 ENOG4105CNI cell division protein FtsW BK816_05675 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BK816_05680 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BK816_05690 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BK816_05695 ENOG4105CJN penicillin-binding protein BK816_05705 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BK816_05710 ENOG4108V6E Cell division protein mraZ BK816_05720 ENOG4107VJY DNA polymerase BK816_05735 ENOG4105EEM helicase BK816_05740 ENOG4105CEY Amp-dependent synthetase and ligase BK816_05745 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BK816_05770 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BK816_05780 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BK816_05785 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BK816_05790 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BK816_05795 ENOG4105CEV competence damage-inducible protein BK816_05805 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BK816_05815 ENOG4105WBV Transcriptional regulator BK816_05830 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BK816_05835 ENOG4105CRK lysyL-tRNA synthetase BK816_05860 ENOG4105C1V Peptidase, M16 BK816_05865 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BK816_05880 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BK816_05885 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BK816_05910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BK816_05915 ENOG4105D8K carboxyl transferase BK816_05925 ENOG4105IBS Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BK816_05930 ENOG4107ZYJ bioY protein BK816_05955 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BK816_05955 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BK816_05970 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) BK816_05990 ENOG4105C72 UPF0176 protein BK816_06000 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BK816_06005 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BK816_06015 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BK816_06025 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BK816_06030 ENOG4105EG2 ABC transporter, permease BK816_06035 ENOG4105D56 permease protein BK816_06055 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BK816_06065 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BK816_06075 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BK816_06085 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BK816_06090 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BK816_06095 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BK816_06110 ENOG4105FDK ABC transporter BK816_06125 ENOG4105E2D ec 3.2.1.52 BK816_06130 ENOG4105ECR NmrA family BK816_06140 ENOG4105CSA Coproporphyrinogen iii oxidase BK816_06145 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BK816_06150 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BK816_06160 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BK816_06170 ENOG4105K8R UPF0145 protein BK816_06190 ENOG4105D7A ATP-binding protein BK816_06195 ENOG4105II7 pyrroline-5-carboxylate reductase BK816_06200 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BK816_06210 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BK816_06215 ENOG41081FY multiple antibiotic resistance (MarC)-related BK816_06270 ENOG4105C3G gtp-binding protein BK816_06275 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BK816_06280 ENOG4105CGY Dna recombination protein BK816_06285 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BK816_06295 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BK816_06300 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BK816_06305 ENOG4108UT2 hemolysin iii BK816_06310 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BK816_06330 ENOG4108V1T peptidylprolyl cis-trans isomerase BK816_06345 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BK816_06365 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BK816_06375 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BK816_06380 ENOG4105CDA abc transporter atp-binding protein BK816_06385 ENOG4105E5Q amino acid AbC transporter BK816_06390 ENOG4106TNF Periplasmic binding protein BK816_06400 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BK816_06415 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 BK816_06460 ENOG4105VEQ Cold shock protein BK816_06465 ENOG4105C5H ABC transporter BK816_06470 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BK816_06485 ENOG4105F8V Hydrolase, tatD family BK816_06495 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BK816_06505 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BK816_06525 ENOG4105SYT Methylenetetrahydrofolate reductase BK816_06530 ENOG4108URH decarboxylase BK816_06535 ENOG4107R4C succinyl-diaminopimelate desuccinylase BK816_06545 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain BK816_06550 ENOG4105CMQ Chloride channel BK816_06555 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BK816_06560 ENOG4105CK7 Sodium proline symporter BK816_06580 ENOG4105UIB (ABC) transporter BK816_06585 ENOG4108JQ9 ABC transporter BK816_06590 ENOG4105DIH basic membrane BK816_06600 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BK816_06605 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BK816_06645 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BK816_06655 ENOG4105I1K ABC transporter BK816_06660 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BK816_06670 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BK816_06675 ENOG4105CSR polyphosphate kinase 2 BK816_06680 ENOG4107QP8 phosphohexose isomerase BK816_06705 ENOG4105CMV Succinyl-CoA synthetase subunit beta BK816_06720 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BK816_06725 ENOG4108JJB ABC transporter BK816_06735 ENOG4105CAT Cytidine monophosphate kinase BK816_06740 ENOG4105WH1 Two component transcriptional regulator luxr family BK816_06770 ENOG4105C7K acetolactate synthase BK816_06775 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BK816_06780 ENOG4108RWI nicotinamidase BK816_06805 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BK816_06810 ENOG4105CRK lysyL-tRNA synthetase BK816_06815 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BK816_06820 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BK816_06845 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BK816_06855 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BK816_06890 ENOG4108IUE nitrate reductase beta subunit BK816_06910 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BK816_06915 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BK816_06940 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BK816_06950 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) BK816_06965 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BK816_06975 ENOG4105D64 Mechanosensitive ion channel BK816_06980 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BK816_07035 ENOG4107R39 (ABC) transporter BK816_07055 ENOG4105XSJ toxin secretion phage lysis holin BK816_07125 ENOG4105EFC phage portal protein HK97 family BK816_07145 ENOG4105DA5 (ABC) transporter BK816_07155 ENOG4105CAR Terminase, large subunit BK816_07180 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BK816_07300 ENOG4108JJ8 (ABC) transporter BK816_07320 ENOG4108IJ9 (ABC) transporter BK816_07340 ENOG4105E2D ec 3.2.1.52 BK816_07350 ENOG4105E2D ec 3.2.1.52 BK816_07355 ENOG4107RCW fructose-bisphosphate aldolase BK816_07360 ENOG4105C2N RNA methyltransferase TrmH family group 3 BK816_07365 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BK816_07370 ENOG4105EMU Dehydrogenase BK816_07380 ENOG4108J59 Extracellular solute-binding protein, family 5 BK816_07390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BK816_07395 ENOG4105DRS transport system, permease BK816_07405 ENOG4105XN3 extracellular solute-binding protein family 1 BK816_07415 ENOG4105EEX Two component transcriptional regulator (Winged helix family BK816_07420 ENOG4105C08 Histidine kinase BK816_07425 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BK816_07430 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BK816_07440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BK816_07460 ENOG4105KNI merR family transcriptional Regulator BK816_07465 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BK816_07470 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BK816_07475 ENOG4105CFG Acts as a chaperone (By similarity) BK816_07495 ENOG4107WGA YidE YbjL BK816_07500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BK816_07515 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BK816_07530 ENOG4108SHJ s-layer protein BK816_07545 ENOG4107SIQ Naphthoate synthase BK816_07565 ENOG4108IQE Amp-dependent synthetase and ligase BK816_07580 ENOG4108RH7 phosphoglycerate mutase BK816_07585 ENOG4108RXW HAD-superfamily subfamily IB hydrolase BK816_07595 ENOG4105DFA alanine racemase domain protein BK816_07600 ENOG4105CZN Potassium uptake protein BK816_07605 ENOG4107ZYR domain protein BK816_07610 ENOG4108KGH TRANSCRIPTIONal BK816_07620 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BK816_07645 ENOG4105EUJ GTP cyclohydrolase i BK816_07650 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BK816_07660 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BK816_07675 ENOG4105F0N pyrophosphate phospho-hydrolase BK816_07680 ENOG4107SUZ Sodium/hydrogen exchanger family BK816_07685 ENOG4107SN7 NLP P60 protein BK816_07750 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BK816_07760 ENOG4105CJQ hydrolase, family 31 BK816_07765 ENOG4105ETE Transcriptional regulator (LacI family BK816_07775 ENOG4105DRS transport system, permease BK816_07780 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BK816_07825 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BK816_07850 ENOG410650H (LipO)protein BK816_07855 ENOG4105DBE peroxidase BK816_07870 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BK816_07890 ENOG4108IPW abc transporter atp-binding protein BK816_07895 ENOG4105CM4 permease protein BK816_07900 ENOG4105DHS permease protein BK816_07910 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BK816_07925 ENOG4105C26 Dehydrogenase BK816_07935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BK816_07940 ENOG4105BZU Histidine kinase BK816_07965 ENOG4105C8N cysteinyl-tRNA synthetase BK816_07975 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BK816_08010 ENOG4105D3R alkyl hydroperoxide reductase BK816_08020 ENOG4107ZR7 Membrane BK816_08050 ENOG4105EWK phytoene BK816_08055 ENOG4108V06 Glutathione peroxidase BK816_08060 ENOG4105VPX protein, conserved in bacteria BK816_08135 ENOG4105C6E dna polymerase iii BK816_08140 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BK816_08155 ENOG4108SGK Tetr family transcriptional regulator BK816_08195 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BK816_08220 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BK816_08225 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BK816_08250 ENOG4108JQ6 ABC transporter BK816_08255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BK816_08260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BK816_08280 ENOG4105C09 Bile acid BK816_08285 ENOG4105C94 Transporter BK816_08295 ENOG4108IUX (ABC) transporter BK816_08305 ENOG4105DFH Transport of potassium into the cell (By similarity) BK816_08320 ENOG4108Z6B deaminase BK816_08325 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BK816_08330 ENOG4105D01 (LipO)protein BK816_08335 ENOG4108UMI ABC transporter, permease BK816_08340 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BK816_08350 ENOG4108ZJ4 polysaccharide deacetylase BK816_08360 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BK816_08365 ENOG4108VJ1 Transcriptional regulator (CarD family BK816_08385 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BK816_08400 ENOG4105CJ1 ABC, transporter BK816_08410 ENOG4105VZ8 Transcriptional regulator BK816_08420 ENOG4105CRQ synthase (Component I) BK816_08425 ENOG4105RGK anthranilate synthase component ii BK816_08430 ENOG4107QYG anthranilate phosphoribosyltransferase BK816_08445 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BK816_08460 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BK816_08535 ENOG4107SIG periplasmic solute binding protein BK816_08540 ENOG4105DIK (ABC) transporter BK816_08545 ENOG4105CC5 ABC transporter BK816_08570 ENOG4105ECB domain protein BK816_08575 ENOG4108IG5 Transcriptional regulator BK816_08585 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BK816_08600 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BK816_08625 ENOG4105E0X reductase BK816_08650 ENOG4108S01 response regulator BK816_08655 ENOG4105BZU Histidine kinase BK816_08665 ENOG4108M15 ABC transporter BK816_08670 ENOG4105CI1 PTS System BK816_08675 ENOG4105BZG amino acid carrier protein BK816_08685 ENOG4107QN2 dihydrolipoyl dehydrogenase BK816_08700 ENOG4105EN6 Membrane BK816_08720 ENOG4105CQ7 ATP-dependent helicase BK816_08760 ENOG4105CV8 reductase BK816_08765 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BK816_08770 ENOG4105TMB Formate nitrite transporter BK816_08775 ENOG4107QTF adenylosuccinate lyase BK816_08800 ENOG4107QNK )-transporter BK816_08825 ENOG4105DQR SNARE associated Golgi BK816_08835 ENOG4107KCI Protein CrcB homolog BK816_08840 ENOG4105WMR Protein CrcB homolog BK816_08860 ENOG4106N3A copper homeostasis protein cutc BK816_08885 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BK816_08890 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BK816_08895 ENOG4105CEY Amp-dependent synthetase and ligase BK816_08900 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) BK816_08910 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BK816_08915 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BK816_08920 ENOG4105BZ4 penicillin-binding protein BK816_08930 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BK816_08945 ENOG4105C3M thioredoxin reductase BK816_08950 ENOG4105K63 Thioredoxin BK816_08955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BK816_08960 ENOG4105CPF Cell wall formation (By similarity) BK816_08970 ENOG4107QJE Chromosome Partitioning Protein BK816_08975 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BK816_08985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BK816_08990 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BK816_08995 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BK816_09000 ENOG41084CH 50S ribosomal protein l34