locus-tag	class	description
HW274_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW274_00010	COG0592	DNA-directed DNA polymerase activity
HW274_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW274_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HW274_00025	COG0187	DNA topoisomerase II activity
HW274_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW274_00065	COG1476	TRANSCRIPTIONal
HW274_00120	COG3764	Sortase (surface protein transpeptidase)
HW274_00135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HW274_00140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW274_00145	COG0360	Binds together with S18 to 16S ribosomal RNA
HW274_00155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW274_00160	COG0359	binds to the 23S rRNA
HW274_00165	COG0534	Mate efflux family protein
HW274_00170	COG0305	Participates in initiation and elongation during chromosome replication
HW274_00180	COG1121	(ABC) transporter
HW274_00190	COG0351	phosphomethylpyrimidine kinase
HW274_00200	COG1733	regulation of RNA biosynthetic process
HW274_00210	COG1760	l-serine dehydratase
HW274_00250	COG1780	Probably involved in ribonucleotide reductase function
HW274_00255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW274_00265	COG0385	Bile acid
HW274_00270	COG1072	(Pantothenic acid kinase))
HW274_00315	COG1609	Transcriptional regulator
HW274_00325	COG2211	Major facilitator Superfamily
HW274_00330	COG0672	)-iron permease
HW274_00340	COG2837	iron assimilation
HW274_00350	COG1309	transcriptional regulator
HW274_00370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HW274_00380	COG1653	transport
HW274_00435	COG0626	cystathionine gamma-synthase activity
HW274_00440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW274_00460	COG1937	Protein conserved in bacteria
HW274_00470	COG2197	response regulator
HW274_00520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW274_00545	COG2813	Specifically methylates the guanine in position
HW274_00560	COG1950	PFAM Membrane protein of
HW274_00565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW274_00645	COG3739	integral membrane protein
HW274_00655	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW274_00665	COG0463	Glycosyl transferase, family 2
HW274_00700	COG2011	ABC-type metal ion transport system permease component
HW274_00705	COG1464	Belongs to the NlpA lipoprotein family
HW274_00725	COG4585	Histidine kinase
HW274_00770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW274_00775	COG2197	response regulator
HW274_00800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW274_00805	COG0590	tRNA wobble adenosine to inosine editing
HW274_00805	COG0037	tRNA processing
HW274_00820	COG1643	Atp-dependent helicase
HW274_00855	COG0702	epimerase
HW274_00885	COG2233	PERMEase
HW274_00940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW274_00965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW274_00975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW274_00985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW274_00990	COG0113	porphobilinogen synthase activity
HW274_01000	COG0181	hydroxymethylbilane synthase activity
HW274_01005	COG3415	Transposase
HW274_01005	COG2801	Transposase and inactivated derivatives
HW274_01015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HW274_01020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HW274_01025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW274_01030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW274_01030	COG3253	May function as heme-dependent peroxidase
HW274_01040	COG0783	Belongs to the Dps family
HW274_01085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW274_01085	COG1918	ferrous iron import across plasma membrane
HW274_01105	COG1597	lipid kinase activity
HW274_01125	COG1028	Short-chain dehydrogenase reductase Sdr
HW274_01130	COG1408	metallophosphoesterase
HW274_01135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW274_01160	COG1136	(ABC) transporter
HW274_01160	COG0577	efflux transmembrane transporter activity
HW274_01170	COG2267	carboxylic ester hydrolase activity
HW274_01175	COG3548	integral membrane protein
HW274_01185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HW274_01235	COG0450	alkyl hydroperoxide reductase
HW274_01240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW274_01270	COG2205	protein histidine kinase activity
HW274_01275	COG0745	RESPONSE REGULATOR receiver
HW274_01290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW274_01290	COG1754	DNA topoisomerase type I activity
HW274_01300	COG0745	RESPONSE REGULATOR receiver
HW274_01305	COG5002	protein histidine kinase activity
HW274_01315	COG2885	chlorophyll binding
HW274_01325	COG2188	Transcriptional regulator
HW274_01355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW274_01360	COG0470	DNA polymerase III
HW274_01385	COG0252	asparaginase activity
HW274_01390	COG1113	amino acid transport
HW274_01405	COG0588	phosphoglycerate mutase activity
HW274_01415	COG5002	protein histidine kinase activity
HW274_01420	COG0745	RESPONSE REGULATOR receiver
HW274_01430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HW274_01460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW274_01475	COG1643	Atp-dependent helicase
HW274_01495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW274_01500	COG2860	membrane
HW274_01520	COG5650	phosphatidylinositol metabolic process
HW274_01555	COG0714	Associated with various cellular activities
HW274_01615	COG0717	Belongs to the dCTP deaminase family
HW274_01625	COG2176	DNA-directed DNA polymerase activity
HW274_01645	COG1028	Short-chain dehydrogenase reductase Sdr
HW274_01650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW274_01655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HW274_01660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW274_01665	COG0191	fructose-bisphosphate aldolase activity
HW274_01695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HW274_01725	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HW274_01775	COG0151	Belongs to the GarS family
HW274_01780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW274_01800	COG0047	phosphoribosylformylglycinamidine synthase activity
HW274_01825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW274_01855	COG1090	epimerase
HW274_01865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW274_01870	COG4085	toxin activity
HW274_01870	COG1525	nuclease
HW274_01870	COG0737	Belongs to the 5'-nucleotidase family
HW274_01875	COG1349	DNA-binding transcription factor activity
HW274_01885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW274_01885	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HW274_01885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW274_01895	COG0557	exoribonuclease II activity
HW274_01900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW274_01905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HW274_01930	COG1132	(ABC) transporter
HW274_01935	COG1132	(ABC) transporter
HW274_01940	COG0577	efflux transmembrane transporter activity
HW274_01945	COG1136	(ABC) transporter
HW274_01955	COG1472	Belongs to the glycosyl hydrolase 3 family
HW274_01995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW274_02005	COG0679	Auxin Efflux Carrier
HW274_02015	COG1722	exodeoxyribonuclease VII activity
HW274_02025	COG0477	Major facilitator Superfamily
HW274_02030	COG1570	exodeoxyribonuclease VII activity
HW274_02035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW274_02040	COG0833	amino acid
HW274_02055	COG1595	DNA-templated transcription, initiation
HW274_02085	COG2261	transglycosylase associated protein
HW274_02090	COG1322	Protein conserved in bacteria
HW274_02100	COG0012	GTP binding
HW274_02155	COG4115	mRNA cleavage
HW274_02165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW274_02170	COG2873	o-acetylhomoserine
HW274_02180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HW274_02185	COG2027	D-alanyl-D-alanine carboxypeptidase
HW274_02195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HW274_02210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_02215	COG0302	gtp cyclohydrolase
HW274_02230	COG2076	Multidrug Resistance protein
HW274_02240	COG2197	response regulator
HW274_02245	COG0577	efflux transmembrane transporter activity
HW274_02245	COG1136	(ABC) transporter
HW274_02250	COG1136	(ABC) transporter
HW274_02255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW274_02260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW274_02285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW274_02290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HW274_02295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HW274_02300	COG1917	Cupin 2, conserved barrel domain protein
HW274_02300	COG2207	Transcriptional regulator
HW274_02320	COG3599	regulation of cell shape
HW274_02335	COG1136	(ABC) transporter
HW274_02345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_02350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_02355	COG1120	ATPase activity
HW274_02360	COG4592	Periplasmic binding protein
HW274_02370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW274_02400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW274_02410	COG3104	oligopeptide transport
HW274_02415	COG3104	oligopeptide transport
HW274_02430	COG1556	Lactate utilization protein
HW274_02435	COG1139	Iron-sulfur cluster binding protein
HW274_02440	COG0247	lactate metabolic process
HW274_02460	COG1620	l-lactate permease
HW274_02470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HW274_02475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW274_02480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW274_02490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HW274_02520	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HW274_02540	COG2814	Major facilitator Superfamily
HW274_02565	COG2376	Dihydroxyacetone kinase
HW274_02570	COG1461	Dihydroxyacetone kinase
HW274_02595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW274_02610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW274_02615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HW274_02630	COG0436	Aminotransferase
HW274_02640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW274_02645	COG0250	Participates in transcription elongation, termination and antitermination
HW274_02650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW274_02655	COG0081	regulation of translation
HW274_02660	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_02675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW274_02675	COG2885	chlorophyll binding
HW274_02730	COG3850	Histidine kinase
HW274_02735	COG2197	response regulator
HW274_02780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW274_02785	COG0049	tRNA binding
HW274_02790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW274_02795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW274_02815	COG0051	transcription antitermination factor activity, RNA binding
HW274_02830	COG0089	rRNA binding
HW274_02835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW274_02840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW274_02845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW274_02850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HW274_02855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW274_02860	COG0255	Belongs to the universal ribosomal protein uL29 family
HW274_02865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW274_02875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW274_02880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HW274_02885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW274_02890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW274_02895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HW274_02900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HW274_02905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW274_02910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW274_02915	COG1841	ribosomal large subunit assembly
HW274_02930	COG0563	adenylate kinase activity
HW274_02935	COG0024	Methionine aminopeptidase
HW274_02940	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_02945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW274_02950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW274_02955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW274_02960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HW274_02965	COG0202	RNA polymerase activity
HW274_02980	COG1285	pathogenesis
HW274_02990	COG0101	tRNA pseudouridine synthase activity
HW274_02995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW274_03000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW274_03030	COG1395	domain, Protein
HW274_03035	COG0596	Alpha beta hydrolase
HW274_03040	COG1072	(Pantothenic acid kinase))
HW274_03050	COG0736	holo-[acyl-carrier-protein] synthase activity
HW274_03060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HW274_03065	COG0802	atpase or kinase
HW274_03090	COG1053	succinate dehydrogenase
HW274_03095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW274_03100	COG0546	phosphoglycolate phosphatase activity
HW274_03105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HW274_03115	COG1132	(ABC) transporter
HW274_03115	COG2375	cellular response to nickel ion
HW274_03125	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HW274_03135	COG2949	membrane
HW274_03140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW274_03160	COG0516	GMP reductase activity
HW274_03165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW274_03170	COG4975	Glucose uptake
HW274_03205	COG0328	RNA-DNA hybrid ribonuclease activity
HW274_03215	COG2197	response regulator
HW274_03220	COG4585	Histidine kinase
HW274_03235	COG1131	(ABC) transporter
HW274_03240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW274_03270	COG1082	Xylose isomerase domain protein TIM barrel
HW274_03275	COG2814	Major facilitator Superfamily
HW274_03280	COG0673	inositol 2-dehydrogenase activity
HW274_03290	COG2017	converts alpha-aldose to the beta-anomer
HW274_03295	COG0673	inositol 2-dehydrogenase activity
HW274_03300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW274_03305	COG2188	Transcriptional regulator
HW274_03320	COG3718	enzyme involved in inositol metabolism
HW274_03325	COG3962	Belongs to the TPP enzyme family
HW274_03340	COG0673	inositol 2-dehydrogenase activity
HW274_03345	COG1082	Xylose isomerase domain protein TIM barrel
HW274_03350	COG2814	Major facilitator Superfamily
HW274_03375	COG0519	Catalyzes the synthesis of GMP from XMP
HW274_03375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW274_03390	COG1131	(ABC) transporter
HW274_03395	COG4585	Histidine kinase
HW274_03425	COG2267	carboxylic ester hydrolase activity
HW274_03435	COG1401	restriction endodeoxyribonuclease activity
HW274_03440	COG4268	DNA restriction-modification system
HW274_03470	COG2205	protein histidine kinase activity
HW274_03475	COG2197	response regulator
HW274_03485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW274_03495	COG0356	it plays a direct role in the translocation of protons across the membrane
HW274_03505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW274_03510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW274_03515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW274_03520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW274_03525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW274_03530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW274_03540	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HW274_03550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW274_03560	COG2801	Transposase and inactivated derivatives
HW274_03580	COG1028	Short-chain dehydrogenase reductase Sdr
HW274_03580	COG3321	synthase
HW274_03580	COG0604	alcohol dehydrogenase
HW274_03585	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW274_03595	COG1960	acyl-CoA dehydrogenase activity
HW274_03615	COG0318	PFAM AMP-dependent synthetase and ligase
HW274_03640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HW274_03645	COG0830	nickel cation binding
HW274_03655	COG0804	urea catabolic process
HW274_03660	COG0832	Belongs to the urease beta subunit family
HW274_03670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW274_03675	COG0254	rRNA binding
HW274_03680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW274_03685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW274_03690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW274_03700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HW274_03705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW274_03710	COG1621	beta-fructofuranosidase activity
HW274_03730	COG1254	Belongs to the acylphosphatase family
HW274_03740	COG1136	(ABC) transporter
HW274_03740	COG0577	efflux transmembrane transporter activity
HW274_03745	COG1136	(ABC) transporter
HW274_03745	COG0577	efflux transmembrane transporter activity
HW274_03755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW274_03760	COG1349	DNA-binding transcription factor activity
HW274_03780	COG1744	ABC transporter substrate-binding protein PnrA-like
HW274_03785	COG3845	ABC transporter
HW274_03790	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW274_03795	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW274_03825	COG0803	Belongs to the bacterial solute-binding protein 9 family
HW274_03830	COG1121	(ABC) transporter
HW274_03845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW274_03850	COG1611	Belongs to the LOG family
HW274_03865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW274_03880	COG2239	Acts as a magnesium transporter
HW274_03890	COG1082	Xylose isomerase domain protein TIM barrel
HW274_03905	COG0006	proline dipeptidase activity
HW274_03910	COG0673	inositol 2-dehydrogenase activity
HW274_03920	COG2095	MarC family integral membrane protein
HW274_03925	COG0513	Belongs to the DEAD box helicase family
HW274_03970	COG0114	fumarate hydratase activity
HW274_03990	COG0346	lactoylglutathione lyase activity
HW274_04000	COG1174	glycine betaine transport
HW274_04020	COG1733	regulation of RNA biosynthetic process
HW274_04030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HW274_04060	COG1674	ftsk spoiiie
HW274_04065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW274_04075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW274_04080	COG0154	amidase activity
HW274_04085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW274_04115	COG2966	Psort location CytoplasmicMembrane, score
HW274_04120	COG0569	domain protein
HW274_04120	COG2985	domain, Protein
HW274_04135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HW274_04150	COG0473	3-isopropylmalate dehydrogenase activity
HW274_04165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW274_04170	COG1316	TRANSCRIPTIONal
HW274_04175	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW274_04180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HW274_04185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW274_04205	COG1216	Glycosyl transferase, family 2
HW274_04215	COG1134	teichoic acid transport
HW274_04235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW274_04245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW274_04265	COG0515	serine threonine protein kinase
HW274_04270	COG1716	ATPase activity
HW274_04270	COG1131	(ABC) transporter
HW274_04270	COG0842	Transport permease protein
HW274_04280	COG1162	GTPase activity
HW274_04285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW274_04290	COG0629	single-stranded DNA binding
HW274_04300	COG2884	Cell division ATP-binding protein ftsE
HW274_04365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_04395	COG0747	negative chemotaxis
HW274_04405	COG0444	Belongs to the ABC transporter superfamily
HW274_04410	COG4608	Belongs to the ABC transporter superfamily
HW274_04425	COG1175	transmembrane transport
HW274_04435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW274_04440	COG1940	carbohydrate kinase activity
HW274_04445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HW274_04465	COG0363	glucosamine-6-phosphate deaminase activity
HW274_04485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HW274_04495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HW274_04515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW274_04520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HW274_04580	COG3304	Inner membrane component domain
HW274_04585	COG0833	amino acid
HW274_04590	COG2040	homocysteine
HW274_04610	COG1115	amino acid carrier protein
HW274_04615	COG1115	amino acid carrier protein
HW274_04620	COG1115	amino acid carrier protein
HW274_04625	COG1115	amino acid carrier protein
HW274_04630	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW274_04640	COG2801	Transposase and inactivated derivatives
HW274_04640	COG3415	Transposase
HW274_04645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW274_04680	COG0726	polysaccharide deacetylase
HW274_04685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW274_04695	COG1674	ftsk spoiiie
HW274_04710	COG1546	Belongs to the CinA family
HW274_04710	COG1058	Belongs to the CinA family
HW274_04715	COG1396	sequence-specific DNA binding
HW274_04725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW274_04730	COG2137	regulation of response to DNA damage stimulus
HW274_04740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HW274_04750	COG0395	ABC-type sugar transport system, permease component
HW274_04765	COG1846	Transcriptional regulator
HW274_04765	COG1940	carbohydrate kinase activity
HW274_04770	COG1252	NADH dehydrogenase
HW274_04775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW274_04800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW274_04805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HW274_04810	COG1114	Component of the transport system for branched-chain amino acids
HW274_04820	COG2813	Specifically methylates the guanine in position
HW274_04835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW274_04850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW274_04860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW274_04875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HW274_04880	COG0066	3-isopropylmalate dehydratase activity
HW274_04885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW274_04895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HW274_04900	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW274_04910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW274_04915	COG1461	Dihydroxyacetone kinase
HW274_04930	COG0235	Class ii aldolase
HW274_04940	COG1070	Carbohydrate kinase
HW274_04945	COG4154	Belongs to the RbsD FucU family
HW274_04950	COG0738	Major facilitator superfamily
HW274_04960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW274_04975	COG0571	ribonuclease III activity
HW274_04980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW274_04995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HW274_05000	COG4988	ABC transporter
HW274_05005	COG1294	oxidase, subunit
HW274_05010	COG1271	oxidase subunit
HW274_05015	COG1530	ribonuclease E activity
HW274_05020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HW274_05025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HW274_05030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW274_05035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW274_05040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW274_05050	COG0745	RESPONSE REGULATOR receiver
HW274_05055	COG5002	protein histidine kinase activity
HW274_05060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW274_05075	COG1132	(ABC) transporter
HW274_05080	COG0297	glycogen (starch) synthase activity
HW274_05090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW274_05095	COG1349	DNA-binding transcription factor activity
HW274_05105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW274_05115	COG0799	negative regulation of ribosome biogenesis
HW274_05120	COG0406	alpha-ribazole phosphatase activity
HW274_05135	COG2095	MarC family integral membrane protein
HW274_05150	COG0813	purine-nucleoside phosphorylase activity
HW274_05155	COG0733	neurotransmitter:sodium symporter activity
HW274_05190	COG0537	adenosine 5'-monophosphoramidase activity
HW274_05205	COG0789	Transcriptional regulator
HW274_05210	COG0495	leucyl-tRNA aminoacylation
HW274_05215	COG0433	COG0433 Predicted ATPase
HW274_05220	COG0438	transferase activity, transferring glycosyl groups
HW274_05225	COG1307	EDD domain protein, DegV family
HW274_05230	COG1555	photosystem II stabilization
HW274_05245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW274_05250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW274_05250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW274_05265	COG4868	Belongs to the UPF0371 family
HW274_05270	COG0268	Binds directly to 16S ribosomal RNA
HW274_05290	COG0159	tryptophan synthase activity
HW274_05305	COG0512	Glutamine amidotransferase of anthranilate synthase
HW274_05310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW274_05315	COG1404	Belongs to the peptidase S8 family
HW274_05330	COG0481	GTPase activity
HW274_05340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW274_05345	COG2807	transmembrane transport
HW274_05355	COG1673	EVE domain
HW274_05375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW274_05390	COG1420	regulation of RNA biosynthetic process
HW274_05395	COG0484	heat shock protein binding
HW274_05400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW274_05430	COG0842	Transport permease protein
HW274_05450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HW274_05460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HW274_05465	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW274_05465	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW274_05465	COG0506	proline dehydrogenase activity
HW274_05470	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW274_05475	COG1476	TRANSCRIPTIONal
HW274_05485	COG1131	(ABC) transporter
HW274_05490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW274_05495	COG1381	Involved in DNA repair and RecF pathway recombination
HW274_05500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW274_05510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW274_05525	COG0423	glycine-tRNA ligase activity
HW274_05550	COG0560	Phosphoserine phosphatase
HW274_05560	COG0297	glycogen (starch) synthase activity
HW274_05570	COG1122	ATPase activity
HW274_05600	COG0488	(ABC) transporter
HW274_05610	COG0545	Peptidyl-prolyl cis-trans isomerase
HW274_05640	COG0205	6-phosphofructokinase activity
HW274_05645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HW274_05650	COG0515	serine threonine protein kinase
HW274_05650	COG2815	serine threonine protein kinase
HW274_05655	COG0142	geranyltranstransferase activity
HW274_05660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW274_05685	COG0187	DNA topoisomerase II activity
HW274_05690	COG0456	acetyltransferase
HW274_05690	COG0454	-acetyltransferase
HW274_05700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW274_05745	COG0569	domain protein
HW274_05750	COG0531	amino acid
HW274_05755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW274_05760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW274_05770	COG1309	transcriptional regulator
HW274_05775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW274_05790	COG4555	ABC transporter
HW274_05805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW274_05810	COG4221	oxidoreductase activity
HW274_05815	COG1881	PFAM PEBP family protein
HW274_05830	COG0671	phosphoesterase, PA-phosphatase related
HW274_05855	COG0587	DNA-directed DNA polymerase activity
HW274_05880	COG3152	Membrane
HW274_05900	COG0477	Major facilitator Superfamily
HW274_05910	COG0028	Belongs to the TPP enzyme family
HW274_05915	COG0339	signal peptide processing
HW274_05920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW274_05930	COG4607	ABC-type enterochelin transport system periplasmic component
HW274_05935	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_05940	COG4605	iron ion homeostasis
HW274_05945	COG4604	ABC transporter, ATP-binding protein
HW274_05950	COG0667	Aldo Keto reductase
HW274_05955	COG0425	Belongs to the sulfur carrier protein TusA family
HW274_05960	COG2391	methyltransferase activity
HW274_05970	COG1994	Peptidase M50
HW274_05970	COG0517	IMP dehydrogenase activity
HW274_05975	COG2837	iron assimilation
HW274_05990	COG1222	aaa ATPase
HW274_06005	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HW274_06015	COG0107	imidazoleglycerol-phosphate synthase activity
HW274_06040	COG0134	indole-3-glycerol-phosphate synthase activity
HW274_06070	COG2050	protein possibly involved in aromatic compounds catabolism
HW274_06080	COG0539	negative regulation of cytoplasmic translation
HW274_06090	COG0237	dephospho-CoA kinase activity
HW274_06095	COG0556	nucleotide-excision repair
HW274_06110	COG2226	methyltransferase
HW274_06155	COG0322	excinuclease ABC activity
HW274_06160	COG3585	molybdate ion transport
HW274_06170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HW274_06175	COG1660	Displays ATPase and GTPase activities
HW274_06185	COG1481	regulation of sporulation
HW274_06190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW274_06195	COG0126	phosphoglycerate kinase activity
HW274_06200	COG0149	triose-phosphate isomerase activity
HW274_06205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW274_06225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW274_06240	COG1160	GTP binding
HW274_06260	COG0166	Belongs to the GPI family
HW274_06265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW274_06295	COG0363	glucosamine-6-phosphate deaminase activity
HW274_06310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW274_06320	COG1716	ATPase activity
HW274_06340	COG0667	Aldo Keto reductase
HW274_06345	COG0443	Heat shock 70 kDa protein
HW274_06360	COG1621	beta-fructofuranosidase activity
HW274_06365	COG1263	PTS System
HW274_06365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_06365	COG2190	(PTS) system
HW274_06370	COG1609	Transcriptional regulator
HW274_06380	COG1136	(ABC) transporter
HW274_06385	COG0577	efflux transmembrane transporter activity
HW274_06390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW274_06400	COG0205	6-phosphofructokinase activity
HW274_06410	COG1216	Glycosyl transferase, family 2
HW274_06415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HW274_06420	COG2354	Protein conserved in bacteria
HW274_06435	COG0805	protein transport
HW274_06460	COG4585	Histidine kinase
HW274_06465	COG2197	response regulator
HW274_06470	COG1131	(ABC) transporter
HW274_06490	COG0140	phosphoribosyl-ATP diphosphatase activity
HW274_06495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HW274_06500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW274_06505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW274_06510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW274_06520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW274_06525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW274_06530	COG4770	biotin carboxylase activity
HW274_06535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW274_06545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW274_06560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW274_06565	COG0549	Belongs to the carbamate kinase family
HW274_06570	COG1834	amidinotransferase
HW274_06595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW274_06605	COG1758	RNA polymerase activity
HW274_06610	COG0194	GDP metabolic process
HW274_06620	COG0284	orotidine-5'-phosphate decarboxylase activity
HW274_06625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW274_06635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW274_06640	COG0540	Belongs to the ATCase OTCase family
HW274_06645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HW274_06665	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_06670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW274_06675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW274_06680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW274_06685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW274_06690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HW274_06695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW274_06705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HW274_06710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW274_06715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW274_06725	COG0009	L-threonylcarbamoyladenylate synthase
HW274_06750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW274_06780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW274_06780	COG1116	anion transmembrane transporter activity
HW274_06810	COG0124	histidyl-tRNA synthetase
HW274_06820	COG0488	(ABC) transporter
HW274_06825	COG1196	nuclear chromosome segregation
HW274_06830	COG0789	Transcriptional regulator
HW274_06840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW274_06845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW274_06850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW274_06855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW274_06865	COG2255	four-way junction helicase activity
HW274_06870	COG0632	four-way junction helicase activity
HW274_06875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HW274_06880	COG0217	transcriptional regulatory protein
HW274_06885	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW274_06890	COG1051	belongs to the nudix hydrolase family
HW274_06895	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HW274_06910	COG0438	transferase activity, transferring glycosyl groups
HW274_06930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW274_06990	COG1882	Formate acetyltransferase
HW274_07000	COG1073	alpha beta
HW274_07005	COG0038	chloride channel
HW274_07015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW274_07020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW274_07025	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW274_07055	COG0321	lipoyl(octanoyl) transferase activity
HW274_07060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HW274_07080	COG0765	amino acid transport
HW274_07095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HW274_07100	COG0174	glutamine synthetase
HW274_07105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HW274_07125	COG3022	response to hydroperoxide
HW274_07135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW274_07150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW274_07340	COG0436	Aminotransferase
HW274_07370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HW274_07380	COG1027	Aspartate ammonia-lyase
HW274_07390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW274_07420	COG0358	DNA primase activity
HW274_07435	COG2801	Transposase and inactivated derivatives
HW274_07435	COG3415	Transposase
HW274_07440	COG2182	Extracellular solute-binding protein
HW274_07445	COG1175	transmembrane transport
HW274_07450	COG3833	ABC-type maltose transport systems, permease component
HW274_07455	COG1609	Transcriptional regulator
HW274_07465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW274_07475	COG0167	dihydroorotate dehydrogenase activity
HW274_07495	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW274_07510	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW274_07525	COG3189	MarR family transcriptional regulator
HW274_07530	COG2151	metal-sulfur cluster biosynthetic enzyme
HW274_07535	COG0822	iron-sulfur transferase activity
HW274_07545	COG0396	ATPase activity
HW274_07565	COG0494	nUDIX hydrolase
HW274_07595	COG0497	DNA recombination
HW274_07600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW274_07615	COG0647	UMP catabolic process
HW274_07640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HW274_07660	COG2094	Belongs to the DNA glycosylase MPG family
HW274_07665	COG0165	Argininosuccinate lyase
HW274_07670	COG2116	formate transmembrane transporter activity
HW274_07675	COG0137	argininosuccinate synthase activity
HW274_07680	COG1438	arginine binding
HW274_07685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW274_07690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW274_07700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW274_07715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW274_07725	COG1131	(ABC) transporter
HW274_07745	COG0765	amino acid transport
HW274_07750	COG0765	amino acid transport
HW274_07755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW274_07760	COG1126	abc transporter atp-binding protein
HW274_07775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW274_07780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW274_07785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW274_07790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HW274_07800	COG1122	ATPase activity
HW274_07815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HW274_07820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW274_07835	COG0131	Imidazoleglycerol-phosphate dehydratase
HW274_07845	COG0025	NhaP-type Na H and K H
HW274_07850	COG0514	ATP-dependent DNA helicase (RecQ)
HW274_07865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW274_07875	COG1215	transferase activity, transferring glycosyl groups
HW274_07885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW274_07890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW274_07910	COG2501	S4 domain
HW274_07915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW274_07920	COG0587	DNA-directed DNA polymerase activity
HW274_07925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW274_07940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW274_07945	COG3599	regulation of cell shape
HW274_07955	COG1799	cell septum assembly
HW274_07960	COG1496	oxidoreductase activity
HW274_07965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW274_07975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW274_07990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW274_07995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW274_08000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW274_08005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW274_08010	COG0768	penicillin binding
HW274_08020	COG0275	rRNA processing
HW274_08025	COG2001	Belongs to the MraZ family
HW274_08035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW274_08055	COG0318	PFAM AMP-dependent synthetase and ligase
HW274_08060	COG0318	PFAM AMP-dependent synthetase and ligase
HW274_08080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HW274_08090	COG0300	oxidoreductase activity
HW274_08095	COG0612	Peptidase, M16
HW274_08100	COG1185	polyribonucleotide nucleotidyltransferase activity
HW274_08110	COG0196	riboflavin kinase activity
HW274_08120	COG0577	efflux transmembrane transporter activity
HW274_08120	COG1136	(ABC) transporter
HW274_08130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW274_08135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HW274_08145	COG0330	HflC and HflK could
HW274_08165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW274_08200	COG0442	prolyl-tRNA aminoacylation
HW274_08235	COG0456	acetyltransferase
HW274_08240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HW274_08245	COG0750	zinc metalloprotease
HW274_08250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HW274_08260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HW274_08270	COG0233	cytoplasmic translational termination
HW274_08280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HW274_08285	COG0052	Belongs to the universal ribosomal protein uS2 family
HW274_08295	COG4974	Belongs to the 'phage' integrase family
HW274_08315	COG1716	ATPase activity
HW274_08340	COG0792	nuclease activity
HW274_08350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW274_08355	COG0681	Belongs to the peptidase S26 family
HW274_08365	COG0681	Belongs to the peptidase S26 family
HW274_08370	COG0336	Belongs to the RNA methyltransferase TrmD family
HW274_08375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW274_08380	COG1837	Belongs to the UPF0109 family
HW274_08400	COG1131	(ABC) transporter
HW274_08410	COG1131	(ABC) transporter
HW274_08420	COG4585	Histidine kinase
HW274_08425	COG2197	response regulator
HW274_08435	COG1131	(ABC) transporter
HW274_08440	COG0842	Transport permease protein
HW274_08445	COG4585	Histidine kinase
HW274_08450	COG2197	response regulator
HW274_08465	COG1196	nuclear chromosome segregation
HW274_08470	COG4152	abc transporter atp-binding protein
HW274_08480	COG0105	UTP biosynthetic process
HW274_08485	COG1461	Dihydroxyacetone kinase
HW274_08490	COG0285	dihydrofolate synthase activity
HW274_08495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW274_08525	COG1215	transferase activity, transferring glycosyl groups
HW274_08530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW274_08535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW274_08560	COG0656	L-ascorbic acid biosynthetic process
HW274_08570	COG4221	oxidoreductase activity
HW274_08575	COG2056	Na+-H+ antiporter family
HW274_08580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW274_08585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW274_08590	COG0175	sulfate reduction
HW274_08605	COG1648	precorrin-2 dehydrogenase activity
HW274_08605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HW274_08610	COG0730	response to heat
HW274_08640	COG1132	(ABC) transporter
HW274_08640	COG2375	cellular response to nickel ion
HW274_08645	COG1122	ATPase activity
HW274_08655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HW274_08665	COG4122	O-methyltransferase activity
HW274_08670	COG1222	aaa ATPase
HW274_08685	COG0454	-acetyltransferase
HW274_08690	COG1609	Transcriptional regulator
HW274_08695	COG0366	Alpha amylase catalytic
HW274_08725	COG1605	Chorismate mutase
HW274_08725	COG0287	Prephenate dehydrogenase
HW274_08730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HW274_08735	COG0740	serine-type endopeptidase activity
HW274_08755	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW274_08775	COG1739	Uncharacterized protein family UPF0029
HW274_08785	COG1045	serine acetyltransferase
HW274_08800	COG0698	ribose 5-phosphate isomerase
HW274_08805	COG3590	peptidase
HW274_08830	COG1263	PTS System
HW274_08835	COG2188	Transcriptional regulator
HW274_08840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_08855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_08860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW274_08900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW274_08975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HW274_08980	COG2326	polyphosphate kinase activity
HW274_09000	COG1615	UPF0182 protein
HW274_09015	COG3480	Lon protease (S16) C-terminal proteolytic domain
HW274_09040	COG1104	cysteine desulfurase activity
HW274_09055	COG0482	sulfurtransferase activity
HW274_09065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW274_09110	COG0180	Tryptophanyl-tRNA synthetase
HW274_09115	COG0366	Alpha amylase catalytic
HW274_09125	COG3281	Trehalose synthase
HW274_09130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HW274_09135	COG0058	SHG alpha-glucan phosphorylase activity
HW274_09170	COG0395	ABC-type sugar transport system, permease component
HW274_09175	COG1175	transmembrane transport
HW274_09185	COG0039	L-malate dehydrogenase activity
HW274_09195	COG1132	(ABC) transporter
HW274_09200	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HW274_09230	COG0045	succinate-CoA ligase (ADP-forming) activity
HW274_09245	COG0205	6-phosphofructokinase activity
HW274_09260	COG0778	Nitroreductase
HW274_09265	COG0366	Alpha amylase catalytic
HW274_09270	COG1501	Belongs to the glycosyl hydrolase 31 family
HW274_09275	COG0110	maltose O-acetyltransferase activity
HW274_09310	COG0604	alcohol dehydrogenase
HW274_09315	COG1846	Transcriptional regulator
HW274_09325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW274_09330	COG0254	rRNA binding
HW274_09345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW274_09350	COG0083	homoserine kinase activity
HW274_09355	COG0460	homoserine dehydrogenase
HW274_09370	COG0019	diaminopimelate decarboxylase activity
HW274_09375	COG0018	arginyl-trna synthetase
HW274_09390	COG0739	heme binding
HW274_09400	COG1253	flavin adenine dinucleotide binding
HW274_09405	COG0567	Dehydrogenase, E1 component
HW274_09405	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW274_09420	COG1595	DNA-templated transcription, initiation
HW274_09430	COG2838	Isocitrate dehydrogenase
HW274_09435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW274_09440	COG1162	GTPase activity
HW274_09470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HW274_09480	COG0314	molybdopterin synthase activity
HW274_09490	COG0315	cyclic pyranopterin monophosphate synthase activity
HW274_09500	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW274_09500	COG0315	cyclic pyranopterin monophosphate synthase activity
HW274_09515	COG1140	nitrate reductase beta subunit
HW274_09540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW274_09545	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_09550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_09560	COG1120	ATPase activity
HW274_09570	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW274_09575	COG0456	acetyltransferase
HW274_09580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW274_09585	COG0483	inositol monophosphate 1-phosphatase activity
HW274_09590	COG1968	undecaprenyl-diphosphatase activity
HW274_09605	COG0420	3'-5' exonuclease activity
HW274_09610	COG0419	ATPase involved in DNA repair
HW274_09640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HW274_09645	COG0085	RNA polymerase activity
HW274_09655	COG0222	ribosome binding
HW274_09660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW274_09700	COG0653	protein targeting
HW274_09710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW274_09720	COG5002	protein histidine kinase activity
HW274_09720	COG5000	phosphorelay sensor kinase activity
HW274_09725	COG0745	RESPONSE REGULATOR receiver
HW274_09745	COG0714	Associated with various cellular activities
HW274_09750	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HW274_09765	COG2835	tetraacyldisaccharide 4'-kinase activity
HW274_09800	COG1482	cell wall glycoprotein biosynthetic process
HW274_09825	COG0438	transferase activity, transferring glycosyl groups
HW274_09830	COG0438	transferase activity, transferring glycosyl groups
HW274_09885	COG0463	Glycosyl transferase, family 2
HW274_09900	COG1088	dTDP-glucose 4,6-dehydratase activity
HW274_09915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW274_09930	COG0297	glycogen (starch) synthase activity
HW274_09945	COG0438	transferase activity, transferring glycosyl groups
HW274_09965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW274_09970	COG0438	transferase activity, transferring glycosyl groups
HW274_09995	COG1316	TRANSCRIPTIONal
HW274_10000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW274_10030	COG5002	protein histidine kinase activity
HW274_10035	COG0745	RESPONSE REGULATOR receiver
HW274_10050	COG0424	maF-like protein
HW274_10065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW274_10085	COG1666	GTP binding
HW274_10090	COG2197	response regulator
HW274_10110	COG0501	Belongs to the peptidase M48B family
HW274_10115	COG0456	acetyltransferase
HW274_10130	COG0142	geranyltranstransferase activity
HW274_10145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW274_10150	COG0713	ATP synthesis coupled electron transport
HW274_10165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HW274_10170	COG1034	ATP synthesis coupled electron transport
HW274_10175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HW274_10185	COG0649	NAD binding
HW274_10190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW274_10195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW274_10205	COG0644	oxidoreductase
HW274_10210	COG2226	methyltransferase
HW274_10215	COG1169	isochorismate synthase
HW274_10220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW274_10225	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HW274_10230	COG4948	Mandelate Racemase Muconate Lactonizing
HW274_10250	COG4176	ABC-type proline glycine betaine transport system permease component
HW274_10260	COG1940	carbohydrate kinase activity
HW274_10265	COG5426	von Willebrand factor, type A
HW274_10275	COG1175	transmembrane transport
HW274_10280	COG0395	ABC-type sugar transport system, permease component
HW274_10295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW274_10300	COG2235	arginine
HW274_10315	COG2197	response regulator
HW274_10320	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW274_10360	COG1397	ADP-ribosylglycohydrolase
HW274_10365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW274_10385	COG0406	alpha-ribazole phosphatase activity
HW274_10390	COG2171	N-acyltransferase activity
HW274_10400	COG1053	succinate dehydrogenase
HW274_10420	COG2814	Major facilitator Superfamily
HW274_10460	COG1217	gtp-binding protein TYPA
HW274_10500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW274_10505	COG0601	transmembrane transport
HW274_10515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW274_10525	COG2267	carboxylic ester hydrolase activity
HW274_10540	COG1902	pentaerythritol trinitrate reductase activity
HW274_10545	COG1733	regulation of RNA biosynthetic process
HW274_10550	COG0604	alcohol dehydrogenase
HW274_10555	COG3012	SEC-C Motif Domain Protein
HW274_10560	COG1362	aminopeptidase activity
HW274_10565	COG0546	phosphoglycolate phosphatase activity
HW274_10670	COG0698	ribose 5-phosphate isomerase
HW274_10675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW274_10680	COG0596	Alpha beta hydrolase
HW274_10680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW274_10690	COG2197	response regulator
HW274_10695	COG4585	Histidine kinase
HW274_10710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HW274_10720	COG0574	Belongs to the PEP-utilizing enzyme family
HW274_10720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW274_10730	COG2211	Major facilitator Superfamily
HW274_10740	COG0438	transferase activity, transferring glycosyl groups
HW274_10740	COG0297	glycogen (starch) synthase activity
HW274_10785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW274_10800	COG1490	D-aminoacyl-tRNA deacylase activity
HW274_10810	COG0354	folic acid binding
HW274_10815	COG3485	protocatechuate 3,4-dioxygenase
HW274_10825	COG0745	RESPONSE REGULATOR receiver
HW274_10830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW274_10850	COG0406	alpha-ribazole phosphatase activity
HW274_10850	COG0494	nUDIX hydrolase
HW274_10855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HW274_10875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_10915	COG0513	Belongs to the DEAD box helicase family
HW274_10930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW274_10940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW274_10955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW274_10970	COG0431	NADPH-dependent FMN reductase
HW274_10975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW274_10995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW274_11010	COG0444	Belongs to the ABC transporter superfamily
HW274_11015	COG0129	dihydroxy-acid dehydratase activity
HW274_11045	COG4585	Histidine kinase
HW274_11050	COG2197	response regulator
HW274_11055	COG0193	aminoacyl-tRNA hydrolase activity
HW274_11060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HW274_11095	COG0148	phosphopyruvate hydratase activity
HW274_11130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW274_11235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW274_11240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HW274_11240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HW274_11250	COG0714	Associated with various cellular activities
HW274_11290	COG0488	(ABC) transporter
HW274_11295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HW274_11300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW274_11315	COG0084	hydrolase, TatD family'
HW274_11320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW274_11330	COG1335	isochorismatase
HW274_11350	COG0697	spore germination
HW274_11355	COG0583	DNA-binding transcription factor activity
HW274_11375	COG2197	response regulator
HW274_11400	COG1297	OPT oligopeptide transporter protein
HW274_11405	COG2814	Major facilitator Superfamily
HW274_11410	COG0640	Transcriptional regulator
HW274_11415	COG1215	transferase activity, transferring glycosyl groups
HW274_11445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW274_11455	COG1970	mechanosensitive ion channel activity
HW274_11480	COG0791	NLP P60 protein
HW274_11480	COG3103	Sh3 type 3 domain protein
HW274_11480	COG1388	LysM domain
HW274_11505	COG3547	Transposase (IS116 IS110 IS902 family)
HW274_11530	COG2252	PERMEase
HW274_11555	COG1061	Type III restriction enzyme res subunit
HW274_11570	COG1842	Phage shock protein A
HW274_11580	COG0745	RESPONSE REGULATOR receiver
HW274_11585	COG2205	protein histidine kinase activity
HW274_11600	COG0459	protein refolding
HW274_11615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HW274_11620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HW274_11625	COG0215	cysteine-tRNA ligase activity
HW274_11630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW274_11660	COG3842	ATPase activity
HW274_11690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW274_11710	COG0561	phosphatase activity
HW274_11730	COG3716	PTS system mannose fructose sorbose family IID component
HW274_11735	COG3715	PTS system
HW274_11740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW274_11740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW274_11745	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW274_11765	COG1609	Transcriptional regulator
HW274_11770	COG0546	phosphoglycolate phosphatase activity
HW274_11785	COG0542	response to heat
HW274_11810	COG0577	efflux transmembrane transporter activity
HW274_11830	COG0745	RESPONSE REGULATOR receiver
HW274_11835	COG2205	protein histidine kinase activity
HW274_11855	COG2311	Membrane
HW274_11860	COG0789	Transcriptional regulator
HW274_11865	COG0484	heat shock protein binding
HW274_11870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW274_11875	COG0443	Heat shock 70 kDa protein
HW274_11885	COG2814	Major facilitator Superfamily
HW274_11890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW274_11900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HW274_11905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_11920	COG1131	(ABC) transporter
HW274_11940	COG2197	response regulator
HW274_11945	COG4585	Histidine kinase
HW274_11985	COG0778	Nitroreductase
HW274_11990	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HW274_12080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW274_12175	COG0601	transmembrane transport
HW274_12180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW274_12185	COG3842	ATPase activity
HW274_12205	COG1733	regulation of RNA biosynthetic process
HW274_12230	COG0247	lactate metabolic process
HW274_12230	COG2181	nitrate reductase activity
HW274_12235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW274_12245	COG2197	response regulator
HW274_12250	COG4585	Histidine kinase
HW274_12295	COG1132	(ABC) transporter
HW274_12335	COG2197	response regulator
HW274_12350	COG2755	lipolytic protein G-D-S-L family
HW274_12365	COG0483	inositol monophosphate 1-phosphatase activity
HW274_12370	COG1113	amino acid transport
HW274_12380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW274_12385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW274_12390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW274_12390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW274_12395	COG1940	carbohydrate kinase activity
HW274_12400	COG4607	ABC-type enterochelin transport system periplasmic component
HW274_12405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_12410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW274_12415	COG1120	ATPase activity
HW274_12425	COG0628	permease
HW274_12435	COG1854	S-ribosylhomocysteine lyase activity
HW274_12445	COG2409	Drug exporters of the RND superfamily
HW274_12465	COG0789	Transcriptional regulator
HW274_12470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW274_12475	COG2985	domain, Protein
HW274_12475	COG0569	domain protein
HW274_12480	COG1966	Carbon starvation protein
HW274_12500	COG1716	ATPase activity
HW274_12505	COG1716	ATPase activity
HW274_12520	COG0768	penicillin binding
HW274_12525	COG0515	serine threonine protein kinase
HW274_12530	COG0515	serine threonine protein kinase
HW274_12530	COG2815	serine threonine protein kinase
HW274_12535	COG2197	response regulator
HW274_12540	COG4585	Histidine kinase
HW274_12550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW274_12555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HW274_12565	COG3345	alpha-galactosidase
HW274_12570	COG0673	inositol 2-dehydrogenase activity
HW274_12575	COG0617	tRNA 3'-terminal CCA addition
HW274_12590	COG0728	peptidoglycan biosynthetic process
HW274_12595	COG0492	ferredoxin-NADP+ reductase activity
HW274_12600	COG3118	belongs to the thioredoxin family
HW274_12610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW274_12615	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW274_12630	COG0357	Ribosomal RNA small subunit methyltransferase G
HW274_12640	COG0706	membrane insertase activity
HW274_12645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HW274_12650	COG0594	ribonuclease P activity
HW274_12655	COG0230	Belongs to the bacterial ribosomal protein bL34 family