locus-tag	class	description
AM609_00015	COG0577	efflux transmembrane transporter activity
AM609_00015	COG1136	(ABC) transporter
AM609_00020	COG3409	Peptidoglycan-binding domain 1 protein
AM609_00050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM609_00065	COG3716	PTS system mannose fructose sorbose family IID component
AM609_00070	COG3715	PTS system
AM609_00080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM609_00095	COG1725	Transcriptional regulator
AM609_00145	COG1132	(ABC) transporter
AM609_00165	COG1940	carbohydrate kinase activity
AM609_00180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM609_00200	COG1643	Atp-dependent helicase
AM609_00225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM609_00250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AM609_00255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM609_00260	COG3142	Participates in the control of copper homeostasis
AM609_00270	COG1132	(ABC) transporter
AM609_00275	COG1132	(ABC) transporter
AM609_00290	COG0714	Associated with various cellular activities
AM609_00305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AM609_00335	COG2860	membrane
AM609_00345	COG3878	Protein conserved in bacteria
AM609_00370	COG0631	protein serine/threonine phosphatase activity
AM609_00395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM609_00445	COG0542	response to heat
AM609_00475	COG0515	serine threonine protein kinase
AM609_00510	COG0443	Heat shock 70 kDa protein
AM609_00695	COG3842	ATPase activity
AM609_00725	COG0601	transmembrane transport
AM609_00730	COG0747	negative chemotaxis
AM609_00765	COG2304	oxidoreductase activity
AM609_00785	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AM609_00785	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AM609_00790	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AM609_00790	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AM609_00805	COG0714	Associated with various cellular activities
AM609_00840	COG0494	nUDIX hydrolase
AM609_00870	COG0717	Belongs to the dCTP deaminase family
AM609_00885	COG0778	Nitroreductase
AM609_00900	COG4221	oxidoreductase activity
AM609_00910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AM609_00940	COG0191	fructose-bisphosphate aldolase activity
AM609_00975	COG3293	Transposase
AM609_00980	COG2272	Belongs to the type-B carboxylesterase lipase family
AM609_00990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM609_01030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AM609_01065	COG0151	Belongs to the GarS family
AM609_01070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AM609_01080	COG0047	phosphoribosylformylglycinamidine synthase activity
AM609_01095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM609_01140	COG0546	phosphoglycolate phosphatase activity
AM609_01185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM609_01195	COG1349	DNA-binding transcription factor activity
AM609_01200	COG1105	Belongs to the carbohydrate kinase PfkB family
AM609_01220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AM609_01255	COG2226	methyltransferase
AM609_01260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AM609_01265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AM609_01300	COG1132	(ABC) transporter
AM609_01310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM609_01320	COG1120	ATPase activity
AM609_01330	COG0577	efflux transmembrane transporter activity
AM609_01330	COG1136	(ABC) transporter
AM609_01355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AM609_01385	COG1136	(ABC) transporter
AM609_01410	COG1556	Lactate utilization protein
AM609_01415	COG1139	Iron-sulfur cluster binding protein
AM609_01420	COG0247	lactate metabolic process
AM609_01470	COG0714	Associated with various cellular activities
AM609_01480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AM609_01480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AM609_01485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM609_01545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM609_01550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM609_01560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AM609_01575	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AM609_01580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AM609_01610	COG1846	Transcriptional regulator
AM609_01610	COG1940	carbohydrate kinase activity
AM609_01660	COG2017	converts alpha-aldose to the beta-anomer
AM609_01685	COG3250	beta-galactosidase activity
AM609_01700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM609_01710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM609_01715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AM609_01725	COG1115	amino acid carrier protein
AM609_01730	COG0436	Aminotransferase
AM609_01765	COG0250	Participates in transcription elongation, termination and antitermination
AM609_01770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AM609_01775	COG0081	regulation of translation
AM609_01780	COG0515	serine threonine protein kinase
AM609_01785	COG2885	chlorophyll binding
AM609_01795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AM609_01800	COG0222	ribosome binding
AM609_01805	COG0085	RNA polymerase activity
AM609_01810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AM609_01820	COG0443	Heat shock 70 kDa protein
AM609_01915	COG1100	Small GTP-binding protein
AM609_01920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AM609_01925	COG0049	tRNA binding
AM609_01930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM609_01935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AM609_01955	COG0051	transcription antitermination factor activity, RNA binding
AM609_01960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AM609_01970	COG0089	rRNA binding
AM609_01975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AM609_01980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AM609_01990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AM609_01995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AM609_02000	COG0255	Belongs to the universal ribosomal protein uL29 family
AM609_02005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AM609_02015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AM609_02020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AM609_02025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AM609_02030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AM609_02040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AM609_02050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AM609_02055	COG1841	ribosomal large subunit assembly
AM609_02080	COG0563	adenylate kinase activity
AM609_02085	COG0024	Methionine aminopeptidase
AM609_02090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AM609_02095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AM609_02100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AM609_02105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM609_02110	COG0202	RNA polymerase activity
AM609_02115	COG0203	ribosomal protein L17
AM609_02130	COG0101	tRNA pseudouridine synthase activity
AM609_02135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AM609_02140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM609_02175	COG1072	(Pantothenic acid kinase))
AM609_02180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM609_02185	COG0736	holo-[acyl-carrier-protein] synthase activity
AM609_02195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM609_02200	COG0802	atpase or kinase
AM609_02220	COG1053	succinate dehydrogenase
AM609_02225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM609_02230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AM609_02235	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AM609_02245	COG2949	membrane
AM609_02250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AM609_02275	COG0516	GMP reductase activity
AM609_02280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM609_02285	COG2095	MarC family integral membrane protein
AM609_02295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM609_02305	COG2814	Major facilitator Superfamily
AM609_02320	COG2186	Transcriptional regulator
AM609_02325	COG0519	Catalyzes the synthesis of GMP from XMP
AM609_02325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM609_02345	COG0667	Aldo Keto reductase
AM609_02370	COG1131	(ABC) transporter
AM609_02375	COG4585	Histidine kinase
AM609_02380	COG2197	response regulator
AM609_02410	COG0583	DNA-binding transcription factor activity
AM609_02435	COG1129	ABC transporter
AM609_02480	COG2814	Major facilitator Superfamily
AM609_02490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM609_02505	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM609_02520	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM609_02570	COG2197	response regulator
AM609_02580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM609_02590	COG0356	it plays a direct role in the translocation of protons across the membrane
AM609_02595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM609_02600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AM609_02605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM609_02610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AM609_02615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM609_02620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AM609_02625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AM609_02640	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AM609_02720	COG1129	ABC transporter
AM609_02740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM609_02745	COG1518	maintenance of DNA repeat elements
AM609_02760	COG1857	crispr-associated protein
AM609_02785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AM609_02800	COG0549	Belongs to the carbamate kinase family
AM609_02830	COG0577	efflux transmembrane transporter activity
AM609_02830	COG1136	(ABC) transporter
AM609_02835	COG1136	(ABC) transporter
AM609_02835	COG0577	efflux transmembrane transporter activity
AM609_02845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AM609_02900	COG0803	Belongs to the bacterial solute-binding protein 9 family
AM609_02905	COG1121	(ABC) transporter
AM609_02920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM609_02950	COG1611	Belongs to the LOG family
AM609_02955	COG4122	O-methyltransferase activity
AM609_02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM609_02970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AM609_02970	COG2755	lipolytic protein G-D-S-L family
AM609_02980	COG2239	Acts as a magnesium transporter
AM609_02990	COG1082	Xylose isomerase domain protein TIM barrel
AM609_03005	COG0006	proline dipeptidase activity
AM609_03020	COG2095	MarC family integral membrane protein
AM609_03025	COG0513	Belongs to the DEAD box helicase family
AM609_03050	COG0210	DNA helicase
AM609_03100	COG0583	DNA-binding transcription factor activity
AM609_03105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AM609_03135	COG1136	(ABC) transporter
AM609_03145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM609_03165	COG1263	PTS System
AM609_03165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM609_03175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM609_03175	COG1263	PTS System
AM609_03195	COG1929	Belongs to the glycerate kinase type-1 family
AM609_03200	COG3590	peptidase
AM609_03225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM609_03230	COG0154	amidase activity
AM609_03235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM609_03265	COG1175	transmembrane transport
AM609_03270	COG0395	ABC-type sugar transport system, permease component
AM609_03280	COG1609	Transcriptional regulator
AM609_03290	COG2985	domain, Protein
AM609_03290	COG0569	domain protein
AM609_03305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AM609_03340	COG0473	3-isopropylmalate dehydrogenase activity
AM609_03345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM609_03350	COG1316	TRANSCRIPTIONal
AM609_03375	COG1216	Glycosyl transferase, family 2
AM609_03375	COG1442	glycosyl transferase family 8
AM609_03395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM609_03450	COG1131	(ABC) transporter
AM609_03450	COG1716	ATPase activity
AM609_03450	COG0842	Transport permease protein
AM609_03465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AM609_03480	COG2884	Cell division ATP-binding protein ftsE
AM609_03485	COG2177	Part of the ABC transporter FtsEX involved in
AM609_03500	COG0667	Aldo Keto reductase
AM609_03510	COG2233	PERMEase
AM609_03515	COG2188	Transcriptional regulator
AM609_03520	COG0747	negative chemotaxis
AM609_03530	COG0444	Belongs to the ABC transporter superfamily
AM609_03535	COG4608	Belongs to the ABC transporter superfamily
AM609_03540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM609_03550	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AM609_03570	COG0363	glucosamine-6-phosphate deaminase activity
AM609_03595	COG3547	Transposase (IS116 IS110 IS902 family)
AM609_03605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM609_03635	COG0442	prolyl-tRNA aminoacylation
AM609_03655	COG0779	Required for maturation of 30S ribosomal subunits
AM609_03670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AM609_03670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AM609_03685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AM609_03690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM609_03695	COG1309	transcriptional regulator
AM609_03700	COG0196	riboflavin kinase activity
AM609_03715	COG0577	efflux transmembrane transporter activity
AM609_03715	COG1136	(ABC) transporter
AM609_03730	COG1185	polyribonucleotide nucleotidyltransferase activity
AM609_03735	COG0612	Peptidase, M16
AM609_03740	COG0300	oxidoreductase activity
AM609_03750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AM609_03775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM609_03780	COG0318	PFAM AMP-dependent synthetase and ligase
AM609_03785	COG0318	PFAM AMP-dependent synthetase and ligase
AM609_03815	COG2001	Belongs to the MraZ family
AM609_03820	COG0275	rRNA processing
AM609_03835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM609_03840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM609_03845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM609_03850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AM609_03865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM609_03885	COG1799	cell septum assembly
AM609_03895	COG3599	regulation of cell shape
AM609_03900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AM609_03915	COG0587	DNA-directed DNA polymerase activity
AM609_03920	COG2501	S4 domain
AM609_04000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AM609_04020	COG0514	ATP-dependent DNA helicase (RecQ)
AM609_04050	COG2078	PFAM AMMECR1 domain protein
AM609_04055	COG1355	regulation of microtubule-based process
AM609_04065	COG0131	Imidazoleglycerol-phosphate dehydratase
AM609_04080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM609_04085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AM609_04100	COG2801	Transposase and inactivated derivatives
AM609_04105	COG2963	transposase activity
AM609_04115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AM609_04120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AM609_04125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM609_04130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM609_04150	COG1126	abc transporter atp-binding protein
AM609_04160	COG0765	amino acid transport
AM609_04165	COG0765	amino acid transport
AM609_04170	COG2814	Major facilitator Superfamily
AM609_04235	COG3304	Inner membrane component domain
AM609_04240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM609_04260	COG1115	amino acid carrier protein
AM609_04265	COG1115	amino acid carrier protein
AM609_04270	COG1115	amino acid carrier protein
AM609_04275	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM609_04290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM609_04315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AM609_04325	COG1674	ftsk spoiiie
AM609_04340	COG1546	Belongs to the CinA family
AM609_04340	COG1058	Belongs to the CinA family
AM609_04345	COG1396	sequence-specific DNA binding
AM609_04355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AM609_04360	COG2137	regulation of response to DNA damage stimulus
AM609_04365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AM609_04375	COG1252	NADH dehydrogenase
AM609_04380	COG0509	glycine decarboxylation via glycine cleavage system
AM609_04385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AM609_04390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM609_04390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM609_04400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM609_04415	COG2188	Transcriptional regulator
AM609_04435	COG0672	)-iron permease
AM609_04440	COG3470	protein probably involved in high-affinity Fe2 transport
AM609_04455	COG0577	efflux transmembrane transporter activity
AM609_04460	COG1136	(ABC) transporter
AM609_04460	COG0577	efflux transmembrane transporter activity
AM609_04480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AM609_04525	COG2813	Specifically methylates the guanine in position
AM609_04535	COG1114	Component of the transport system for branched-chain amino acids
AM609_04540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AM609_04555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM609_04580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AM609_04600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AM609_04605	COG0066	3-isopropylmalate dehydratase activity
AM609_04610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM609_04620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AM609_04650	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM609_04680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM609_04685	COG1461	Dihydroxyacetone kinase
AM609_04710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AM609_04730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AM609_04755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AM609_04760	COG4988	ABC transporter
AM609_04765	COG1294	oxidase, subunit
AM609_04770	COG1271	oxidase subunit
AM609_04775	COG1530	ribonuclease E activity
AM609_04780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AM609_04785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AM609_04790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AM609_04795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AM609_04850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AM609_04860	COG0745	RESPONSE REGULATOR receiver
AM609_04865	COG5002	protein histidine kinase activity
AM609_04885	COG1132	(ABC) transporter
AM609_04905	COG1349	DNA-binding transcription factor activity
AM609_04910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AM609_04920	COG0799	negative regulation of ribosome biogenesis
AM609_04925	COG0406	alpha-ribazole phosphatase activity
AM609_05005	COG0537	adenosine 5'-monophosphoramidase activity
AM609_05010	COG0495	leucyl-tRNA aminoacylation
AM609_05035	COG1307	EDD domain protein, DegV family
AM609_05055	COG4868	Belongs to the UPF0371 family
AM609_05060	COG0268	Binds directly to 16S ribosomal RNA
AM609_05085	COG0577	efflux transmembrane transporter activity
AM609_05085	COG1136	(ABC) transporter
AM609_05095	COG2197	response regulator
AM609_05120	COG2197	response regulator
AM609_05140	COG0159	tryptophan synthase activity
AM609_05150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM609_05155	COG0512	Glutamine amidotransferase of anthranilate synthase
AM609_05160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM609_05175	COG1216	Glycosyl transferase, family 2
AM609_05185	COG0481	GTPase activity
AM609_05195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM609_05230	COG1420	regulation of RNA biosynthetic process
AM609_05235	COG0484	heat shock protein binding
AM609_05285	COG0640	Transcriptional regulator
AM609_05300	COG0443	Heat shock 70 kDa protein
AM609_05310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AM609_05330	COG0506	proline dehydrogenase activity
AM609_05330	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM609_05330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM609_05335	COG2337	Toxic component of a toxin-antitoxin (TA) module
AM609_05340	COG3609	addiction module antidote protein, CC2985 family
AM609_05350	COG1476	TRANSCRIPTIONal
AM609_05360	COG1131	(ABC) transporter
AM609_05370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM609_05375	COG1381	Involved in DNA repair and RecF pathway recombination
AM609_05385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM609_05390	COG1121	(ABC) transporter
AM609_05400	COG0423	glycine-tRNA ligase activity
AM609_05425	COG0560	Phosphoserine phosphatase
AM609_05435	COG0297	glycogen (starch) synthase activity
AM609_05445	COG1119	ATPase activity
AM609_05475	COG2326	polyphosphate kinase activity
AM609_05490	COG0488	(ABC) transporter
AM609_05505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM609_05545	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AM609_05555	COG2815	serine threonine protein kinase
AM609_05555	COG0515	serine threonine protein kinase
AM609_05565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM609_05585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AM609_05635	COG0569	domain protein
AM609_05640	COG0531	amino acid
AM609_05645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM609_05655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM609_05665	COG2197	response regulator
AM609_05695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM609_05710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM609_05715	COG4221	oxidoreductase activity
AM609_05720	COG1881	PFAM PEBP family protein
AM609_05730	COG1435	thymidine kinase activity
AM609_05745	COG0676	glucose-6-phosphate 1-epimerase activity
AM609_05770	COG0339	signal peptide processing
AM609_05775	COG1252	NADH dehydrogenase
AM609_05785	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM609_05790	COG4605	iron ion homeostasis
AM609_05800	COG0667	Aldo Keto reductase
AM609_05810	COG1994	Peptidase M50
AM609_05810	COG0517	IMP dehydrogenase activity
AM609_05820	COG2264	protein methyltransferase activity
AM609_05830	COG1222	aaa ATPase
AM609_05835	COG4122	O-methyltransferase activity
AM609_05845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AM609_05865	COG0134	indole-3-glycerol-phosphate synthase activity
AM609_05900	COG0539	negative regulation of cytoplasmic translation
AM609_05910	COG0237	dephospho-CoA kinase activity
AM609_05915	COG0556	nucleotide-excision repair
AM609_05920	COG0861	Integral membrane protein TerC family
AM609_05925	COG0861	Integral membrane protein TerC family
AM609_05935	COG1012	belongs to the aldehyde dehydrogenase family
AM609_06000	COG0322	excinuclease ABC activity
AM609_06005	COG3585	molybdate ion transport
AM609_06020	COG1660	Displays ATPase and GTPase activities
AM609_06025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AM609_06030	COG1481	regulation of sporulation
AM609_06035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM609_06045	COG0149	triose-phosphate isomerase activity
AM609_06050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AM609_06070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AM609_06095	COG1160	GTP binding
AM609_06110	COG0166	Belongs to the GPI family
AM609_06190	COG1136	(ABC) transporter
AM609_06220	COG3842	ATPase activity
AM609_06225	COG0395	ABC-type sugar transport system, permease component
AM609_06230	COG1175	transmembrane transport
AM609_06245	COG1082	Xylose isomerase domain protein TIM barrel
AM609_06260	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AM609_06415	COG0433	COG0433 Predicted ATPase
AM609_06415	COG1674	ftsk spoiiie
AM609_06430	COG0515	serine threonine protein kinase
AM609_06510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AM609_06540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AM609_06545	COG1716	ATPase activity
AM609_06580	COG1621	beta-fructofuranosidase activity
AM609_06585	COG2190	(PTS) system
AM609_06585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM609_06585	COG1263	PTS System
AM609_06610	COG0577	efflux transmembrane transporter activity
AM609_06630	COG0477	Major facilitator Superfamily
AM609_06665	COG0205	6-phosphofructokinase activity
AM609_06675	COG1216	Glycosyl transferase, family 2
AM609_06705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM609_06725	COG0140	phosphoribosyl-ATP diphosphatase activity
AM609_06730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM609_06740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM609_06745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM609_06750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM609_06765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM609_06770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM609_06775	COG4770	biotin carboxylase activity
AM609_06825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM609_06835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM609_06850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AM609_06860	COG1758	RNA polymerase activity
AM609_06865	COG0194	GDP metabolic process
AM609_06870	COG0284	orotidine-5'-phosphate decarboxylase activity
AM609_06875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AM609_06885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AM609_06890	COG0540	Belongs to the ATCase OTCase family
AM609_06895	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AM609_06905	COG0702	epimerase
AM609_06910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM609_06915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AM609_06930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AM609_06935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AM609_06940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM609_06950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM609_06960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AM609_06965	COG0730	response to heat
AM609_07005	COG0009	L-threonylcarbamoyladenylate synthase
AM609_07020	COG1063	alcohol dehydrogenase
AM609_07040	COG5265	(ABC) transporter
AM609_07045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AM609_07060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM609_07070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM609_07070	COG1116	anion transmembrane transporter activity
AM609_07095	COG0124	histidyl-tRNA synthetase
AM609_07110	COG0488	(ABC) transporter
AM609_07115	COG1196	nuclear chromosome segregation
AM609_07125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM609_07130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AM609_07135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM609_07140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM609_07150	COG2255	four-way junction helicase activity
AM609_07155	COG0632	four-way junction helicase activity
AM609_07160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AM609_07165	COG0217	transcriptional regulatory protein
AM609_07185	COG0438	transferase activity, transferring glycosyl groups
AM609_07190	COG1560	Kdo2-lipid A biosynthetic process
AM609_07205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AM609_07250	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AM609_07265	COG1882	Formate acetyltransferase
AM609_07295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AM609_07300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM609_07330	COG0321	lipoyl(octanoyl) transferase activity
AM609_07335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM609_07355	COG0765	amino acid transport
AM609_07380	COG0406	alpha-ribazole phosphatase activity
AM609_07390	COG0174	glutamine synthetase
AM609_07395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AM609_07400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM609_07400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM609_07470	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AM609_07500	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AM609_07505	COG1027	Aspartate ammonia-lyase
AM609_07515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM609_07560	COG0358	DNA primase activity
AM609_07585	COG2182	Extracellular solute-binding protein
AM609_07595	COG3833	ABC-type maltose transport systems, permease component
AM609_07600	COG3103	Sh3 type 3 domain protein
AM609_07600	COG0366	Alpha amylase catalytic
AM609_07605	COG1609	Transcriptional regulator
AM609_07610	COG1929	Belongs to the glycerate kinase type-1 family
AM609_07615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM609_07625	COG0667	Aldo Keto reductase
AM609_07655	COG0167	dihydroorotate dehydrogenase activity
AM609_07685	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AM609_07700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AM609_07705	COG2151	metal-sulfur cluster biosynthetic enzyme
AM609_07720	COG0396	ATPase activity
AM609_07745	COG1609	Transcriptional regulator
AM609_07755	COG1175	transmembrane transport
AM609_07800	COG0497	DNA recombination
AM609_07805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM609_07820	COG0647	UMP catabolic process
AM609_07845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AM609_07865	COG2094	Belongs to the DNA glycosylase MPG family
AM609_07870	COG0165	Argininosuccinate lyase
AM609_07885	COG0137	argininosuccinate synthase activity
AM609_07890	COG1438	arginine binding
AM609_07900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM609_07910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AM609_07940	COG1131	(ABC) transporter
AM609_07955	COG1175	transmembrane transport
AM609_07980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AM609_07985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AM609_07990	COG0454	-acetyltransferase
AM609_07990	COG0456	acetyltransferase
AM609_07995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AM609_08040	COG0750	zinc metalloprotease
AM609_08045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM609_08055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AM609_08065	COG0233	cytoplasmic translational termination
AM609_08075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AM609_08080	COG0052	Belongs to the universal ribosomal protein uS2 family
AM609_08100	COG0606	chelatase, subunit chli
AM609_08105	COG0792	nuclease activity
AM609_08115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM609_08120	COG0681	Belongs to the peptidase S26 family
AM609_08130	COG0335	large ribosomal subunit rRNA binding
AM609_08135	COG0681	Belongs to the peptidase S26 family
AM609_08140	COG0336	Belongs to the RNA methyltransferase TrmD family
AM609_08145	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM609_08150	COG1837	Belongs to the UPF0109 family
AM609_08155	COG0228	four-way junction DNA binding
AM609_08170	COG1131	(ABC) transporter
AM609_08180	COG4585	Histidine kinase
AM609_08185	COG2197	response regulator
AM609_08190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM609_08200	COG1131	(ABC) transporter
AM609_08205	COG0842	Transport permease protein
AM609_08210	COG4585	Histidine kinase
AM609_08215	COG2197	response regulator
AM609_08245	COG2197	response regulator
AM609_08270	COG4152	abc transporter atp-binding protein
AM609_08280	COG0105	UTP biosynthetic process
AM609_08290	COG1461	Dihydroxyacetone kinase
AM609_08295	COG0285	dihydrofolate synthase activity
AM609_08300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM609_08325	COG1215	transferase activity, transferring glycosyl groups
AM609_08435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM609_08440	COG2188	Transcriptional regulator
AM609_08445	COG2190	(PTS) system
AM609_08445	COG1263	PTS System
AM609_08445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM609_08450	COG0366	Alpha amylase catalytic
AM609_08480	COG4115	mRNA cleavage
AM609_08485	COG2161	toxin-antitoxin pair type II binding
AM609_08495	COG3177	Filamentation induced by cAMP protein fic
AM609_08510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AM609_08515	COG1129	ABC transporter
AM609_08545	COG1605	Chorismate mutase
AM609_08545	COG0287	Prephenate dehydrogenase
AM609_08550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AM609_08555	COG0740	serine-type endopeptidase activity
AM609_08560	COG0740	serine-type endopeptidase activity
AM609_08565	COG1116	anion transmembrane transporter activity
AM609_08620	COG0738	Major facilitator superfamily
AM609_08685	COG2963	transposase activity
AM609_08740	COG1739	Uncharacterized protein family UPF0029
AM609_08750	COG1045	serine acetyltransferase
AM609_08755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM609_08795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AM609_08805	COG1732	Glycine betaine
AM609_08815	COG1174	glycine betaine transport
AM609_08845	COG0346	lactoylglutathione lyase activity
AM609_08860	COG2205	protein histidine kinase activity
AM609_08875	COG0114	fumarate hydratase activity
AM609_08880	COG2315	Protein conserved in bacteria
AM609_08900	COG2197	response regulator
AM609_08920	COG1615	UPF0182 protein
AM609_08935	COG3480	Lon protease (S16) C-terminal proteolytic domain
AM609_09000	COG0482	sulfurtransferase activity
AM609_09010	COG1131	(ABC) transporter
AM609_09015	COG1725	Transcriptional regulator
AM609_09040	COG3831	ATPase activity
AM609_09060	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AM609_09070	COG0714	Associated with various cellular activities
AM609_09080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AM609_09085	COG2086	electron transfer activity
AM609_09100	COG1234	tRNA 3'-trailer cleavage
AM609_09120	COG0366	Alpha amylase catalytic
AM609_09125	COG3281	Trehalose synthase
AM609_09130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AM609_09135	COG0058	SHG alpha-glucan phosphorylase activity
AM609_09175	COG0039	L-malate dehydrogenase activity
AM609_09205	COG0045	succinate-CoA ligase (ADP-forming) activity
AM609_09215	COG0205	6-phosphofructokinase activity
AM609_09270	COG1609	Transcriptional regulator
AM609_09295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM609_09310	COG1175	transmembrane transport
AM609_09320	COG1846	Transcriptional regulator
AM609_09320	COG1940	carbohydrate kinase activity
AM609_09330	COG1609	Transcriptional regulator
AM609_09340	COG1175	transmembrane transport
AM609_09345	COG0395	ABC-type sugar transport system, permease component
AM609_09355	COG1028	Short-chain dehydrogenase reductase Sdr
AM609_09385	COG3293	Transposase
AM609_09425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AM609_09430	COG0254	rRNA binding
AM609_09450	COG0083	homoserine kinase activity
AM609_09455	COG0460	homoserine dehydrogenase
AM609_09465	COG4172	Belongs to the ABC transporter superfamily
AM609_09520	COG0019	diaminopimelate decarboxylase activity
AM609_09525	COG0018	arginyl-trna synthetase
AM609_09560	COG2272	Belongs to the type-B carboxylesterase lipase family
AM609_09565	COG0584	glycerophosphoryl diester phosphodiesterase
AM609_09570	COG1196	nuclear chromosome segregation
AM609_09570	COG0741	lytic transglycosylase activity
AM609_09570	COG0739	heme binding
AM609_09600	COG0567	Dehydrogenase, E1 component
AM609_09600	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM609_09630	COG1309	transcriptional regulator
AM609_09635	COG1131	(ABC) transporter
AM609_09645	COG5662	AntiSigma factor
AM609_09650	COG1595	DNA-templated transcription, initiation
AM609_09660	COG2838	Isocitrate dehydrogenase
AM609_09665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM609_09670	COG1162	GTPase activity
AM609_09700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM609_09710	COG0314	molybdopterin synthase activity
AM609_09730	COG0315	cyclic pyranopterin monophosphate synthase activity
AM609_09730	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM609_09745	COG1140	nitrate reductase beta subunit
AM609_09790	COG1063	alcohol dehydrogenase
AM609_09810	COG0483	inositol monophosphate 1-phosphatase activity
AM609_09815	COG1968	undecaprenyl-diphosphatase activity
AM609_09850	COG0420	3'-5' exonuclease activity
AM609_09855	COG0419	ATPase involved in DNA repair
AM609_09895	COG0653	protein targeting
AM609_09905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM609_09915	COG5002	protein histidine kinase activity
AM609_09915	COG5000	phosphorelay sensor kinase activity
AM609_09920	COG0745	RESPONSE REGULATOR receiver
AM609_09940	COG0714	Associated with various cellular activities
AM609_09945	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AM609_09990	COG1482	cell wall glycoprotein biosynthetic process
AM609_10075	COG0697	spore germination
AM609_10110	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM609_10140	COG0438	transferase activity, transferring glycosyl groups
AM609_10180	COG1316	TRANSCRIPTIONal
AM609_10185	COG1316	TRANSCRIPTIONal
AM609_10190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM609_10195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM609_10225	COG0586	Pfam SNARE associated Golgi protein
AM609_10230	COG5002	protein histidine kinase activity
AM609_10235	COG0745	RESPONSE REGULATOR receiver
AM609_10275	COG2205	protein histidine kinase activity
AM609_10280	COG0745	RESPONSE REGULATOR receiver
AM609_10290	COG0424	maF-like protein
AM609_10340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM609_10350	COG0501	Belongs to the peptidase M48B family
AM609_10355	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AM609_10440	COG0686	Belongs to the AlaDH PNT family
AM609_10460	COG1007	ATP synthesis coupled electron transport
AM609_10470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM609_10475	COG0713	ATP synthesis coupled electron transport
AM609_10485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM609_10490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AM609_10495	COG1034	ATP synthesis coupled electron transport
AM609_10500	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AM609_10510	COG0649	NAD binding
AM609_10515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM609_10520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM609_10545	COG2226	methyltransferase
AM609_10550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM609_10555	COG4948	Mandelate Racemase Muconate Lactonizing
AM609_10560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AM609_10580	COG2235	arginine
AM609_10595	COG1595	DNA-templated transcription, initiation
AM609_10610	COG0758	DNA mediated transformation
AM609_10650	COG0406	alpha-ribazole phosphatase activity
AM609_10655	COG2171	N-acyltransferase activity
AM609_10665	COG1053	succinate dehydrogenase
AM609_10690	COG4115	mRNA cleavage
AM609_10695	COG2161	toxin-antitoxin pair type II binding
AM609_10700	COG2723	6-phospho-beta-galactosidase activity
AM609_10770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM609_10775	COG0601	transmembrane transport
AM609_10785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM609_10795	COG1268	BioY protein
AM609_10825	COG4667	esterase of the alpha-beta hydrolase superfamily
AM609_10830	COG1902	pentaerythritol trinitrate reductase activity
AM609_10840	COG3012	SEC-C Motif Domain Protein
AM609_10845	COG1362	aminopeptidase activity
AM609_10905	COG3177	Filamentation induced by cAMP protein fic
AM609_10910	COG0698	ribose 5-phosphate isomerase
AM609_10920	COG1285	pathogenesis
AM609_10975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AM609_10985	COG3093	addiction module antidote protein HigA
AM609_10995	COG0012	GTP binding
AM609_11005	COG1322	Protein conserved in bacteria
AM609_11020	COG1570	exodeoxyribonuclease VII activity
AM609_11025	COG1722	exodeoxyribonuclease VII activity
AM609_11035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AM609_11040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM609_11050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM609_11055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM609_11070	COG0583	DNA-binding transcription factor activity
AM609_11085	COG1695	Transcriptional regulator
AM609_11095	COG0431	NADPH-dependent FMN reductase
AM609_11100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM609_11105	COG1073	alpha beta
AM609_11120	COG1309	transcriptional regulator
AM609_11135	COG0129	dihydroxy-acid dehydratase activity
AM609_11140	COG1619	proteins homologs of microcin C7 resistance protein MccF
AM609_11185	COG1131	(ABC) transporter
AM609_11195	COG4585	Histidine kinase
AM609_11200	COG2197	response regulator
AM609_11205	COG0193	aminoacyl-tRNA hydrolase activity
AM609_11210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AM609_11215	COG0710	3-dehydroquinate dehydratase activity
AM609_11235	COG0148	phosphopyruvate hydratase activity
AM609_11260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM609_11270	COG1309	transcriptional regulator
AM609_11275	COG0488	(ABC) transporter
AM609_11280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AM609_11285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM609_11300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM609_11345	COG1959	2 iron, 2 sulfur cluster binding
AM609_11370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM609_11380	COG1970	mechanosensitive ion channel activity
AM609_11405	COG0791	NLP P60 protein
AM609_11405	COG1388	LysM domain
AM609_11405	COG3103	Sh3 type 3 domain protein
AM609_11425	COG2252	PERMEase
AM609_11430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM609_11445	COG1012	belongs to the aldehyde dehydrogenase family
AM609_11455	COG0302	gtp cyclohydrolase
AM609_11460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM609_11550	COG1518	maintenance of DNA repeat elements
AM609_11605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM609_11615	COG2873	o-acetylhomoserine
AM609_11620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM609_11625	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AM609_11655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AM609_11660	COG0714	Associated with various cellular activities
AM609_11670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM609_11670	COG0574	Belongs to the PEP-utilizing enzyme family
AM609_11690	COG0542	response to heat
AM609_11705	COG4585	Histidine kinase
AM609_11845	COG0714	Associated with various cellular activities
AM609_11880	COG1490	D-aminoacyl-tRNA deacylase activity
AM609_11890	COG0354	folic acid binding
AM609_11895	COG3485	protocatechuate 3,4-dioxygenase
AM609_11905	COG0745	RESPONSE REGULATOR receiver
AM609_11915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AM609_11970	COG0513	Belongs to the DEAD box helicase family
AM609_11985	COG3293	Transposase
AM609_12040	COG1121	(ABC) transporter
AM609_12060	COG0577	efflux transmembrane transporter activity
AM609_12070	COG1472	Belongs to the glycosyl hydrolase 3 family
AM609_12075	COG4975	Glucose uptake
AM609_12085	COG1061	Type III restriction enzyme res subunit
AM609_12130	COG0745	RESPONSE REGULATOR receiver
AM609_12135	COG2205	protein histidine kinase activity
AM609_12160	COG0459	protein refolding
AM609_12175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AM609_12205	COG3842	ATPase activity
AM609_12230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM609_12235	COG0215	cysteine-tRNA ligase activity
AM609_12240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AM609_12250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM609_12295	COG1349	DNA-binding transcription factor activity
AM609_12300	COG3104	oligopeptide transport
AM609_12310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM609_12315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM609_12315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM609_12315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM609_12335	COG1309	transcriptional regulator
AM609_12345	COG0542	response to heat
AM609_12355	COG3655	Transcriptional regulator
AM609_12370	COG1505	serine-type exopeptidase activity
AM609_12390	COG0745	RESPONSE REGULATOR receiver
AM609_12400	COG0789	Transcriptional regulator
AM609_12405	COG0484	heat shock protein binding
AM609_12410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AM609_12415	COG0443	Heat shock 70 kDa protein
AM609_12430	COG1136	(ABC) transporter
AM609_12430	COG0577	efflux transmembrane transporter activity
AM609_12505	COG0471	metal ion transport
AM609_12545	COG3311	Transcriptional regulator
AM609_12565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM609_12600	COG1201	RNA secondary structure unwinding
AM609_12605	COG0210	DNA helicase
AM609_12630	COG1401	restriction endodeoxyribonuclease activity
AM609_12690	COG1309	transcriptional regulator
AM609_12710	COG2885	chlorophyll binding
AM609_12720	COG2205	protein histidine kinase activity
AM609_12725	COG0745	RESPONSE REGULATOR receiver
AM609_12735	COG1754	DNA topoisomerase type I activity
AM609_12735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM609_12750	COG0745	RESPONSE REGULATOR receiver
AM609_12755	COG2205	protein histidine kinase activity
AM609_12760	COG1472	Belongs to the glycosyl hydrolase 3 family
AM609_12810	COG0489	protein tyrosine kinase activity
AM609_12845	COG0596	Alpha beta hydrolase
AM609_12855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM609_12865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AM609_12895	COG1597	lipid kinase activity
AM609_12980	COG0494	nUDIX hydrolase
AM609_13000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AM609_13010	COG0181	hydroxymethylbilane synthase activity
AM609_13015	COG0113	porphobilinogen synthase activity
AM609_13025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AM609_13030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM609_13030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM609_13030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM609_13045	COG2723	6-phospho-beta-galactosidase activity
AM609_13075	COG0783	Belongs to the Dps family
AM609_13100	COG2197	response regulator
AM609_13105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM609_13170	COG1131	(ABC) transporter
AM609_13190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AM609_13235	COG3386	PFAM SMP-30 Gluconolaconase
AM609_13245	COG3588	fructose-bisphosphate aldolase
AM609_13250	COG1609	Transcriptional regulator
AM609_13260	COG2211	Major facilitator Superfamily
AM609_13335	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
AM609_13360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AM609_13390	COG3579	cysteine-type endopeptidase activity
AM609_13405	COG1950	PFAM Membrane protein of
AM609_13410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM609_13420	COG1937	Protein conserved in bacteria
AM609_13460	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AM609_13470	COG1737	Transcriptional regulator
AM609_13475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM609_13510	COG0477	Major facilitator Superfamily
AM609_13520	COG0237	dephospho-CoA kinase activity
AM609_13540	COG1780	Probably involved in ribonucleotide reductase function
AM609_13575	COG0366	Alpha amylase catalytic
AM609_13585	COG3550	peptidyl-serine autophosphorylation
AM609_13590	COG1760	l-serine dehydratase
AM609_13605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AM609_13610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AM609_13615	COG1113	amino acid transport
AM609_13630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM609_13630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM609_13860	COG0628	permease
AM609_13870	COG2197	response regulator
AM609_13915	COG0577	efflux transmembrane transporter activity
AM609_13915	COG1136	(ABC) transporter
AM609_13925	COG3177	Filamentation induced by cAMP protein fic
AM609_13935	COG2197	response regulator
AM609_13945	COG0170	dolichyl monophosphate biosynthetic process
AM609_13950	COG1136	(ABC) transporter
AM609_13950	COG0577	efflux transmembrane transporter activity
AM609_13960	COG1136	(ABC) transporter
AM609_13960	COG0577	efflux transmembrane transporter activity
AM609_13975	COG0477	Major facilitator Superfamily
AM609_14010	COG0471	metal ion transport
AM609_14025	COG1854	S-ribosylhomocysteine lyase activity
AM609_14040	COG2267	carboxylic ester hydrolase activity
AM609_14050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM609_14080	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AM609_14085	COG3293	Transposase
AM609_14100	COG1716	ATPase activity
AM609_14105	COG1716	ATPase activity
AM609_14120	COG0768	penicillin binding
AM609_14125	COG0515	serine threonine protein kinase
AM609_14140	COG3764	Sortase (surface protein transpeptidase)
AM609_14185	COG0187	DNA topoisomerase II activity
AM609_14195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM609_14200	COG0592	DNA-directed DNA polymerase activity
AM609_14205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AM609_14210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AM609_14215	COG0594	ribonuclease P activity
AM609_14220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM609_14225	COG0706	membrane insertase activity
AM609_14235	COG0357	Ribosomal RNA small subunit methyltransferase G
AM609_14240	COG1192	Involved in chromosome partitioning
AM609_14255	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM609_14260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM609_14265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM609_14270	COG0110	maltose O-acetyltransferase activity
AM609_14275	COG3118	belongs to the thioredoxin family
AM609_14305	COG0617	tRNA 3'-terminal CCA addition
AM609_14380	COG2197	response regulator
AM609_14395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM609_14460	COG0789	Transcriptional regulator
AM609_14465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AM609_14480	COG0360	Binds together with S18 to 16S ribosomal RNA
AM609_14490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AM609_14495	COG0359	binds to the 23S rRNA
AM609_14510	COG2197	response regulator
AM609_14515	COG0534	Mate efflux family protein
AM609_14520	COG0305	Participates in initiation and elongation during chromosome replication
AM609_14525	COG3177	Filamentation induced by cAMP protein fic
AM609_14535	COG0833	amino acid
AM609_14540	COG1834	amidinotransferase
AM609_14550	COG1121	(ABC) transporter
AM609_14570	COG0351	phosphomethylpyrimidine kinase
AM609_14605	COG1716	ATPase activity
AM609_14605	COG0842	Transport permease protein
AM609_14605	COG1131	(ABC) transporter
AM609_14615	COG1404	Belongs to the peptidase S8 family
AM609_14620	COG0483	inositol monophosphate 1-phosphatase activity
AM609_14695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM609_14705	COG1464	Belongs to the NlpA lipoprotein family
AM609_14745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AM609_14750	COG2197	response regulator
AM609_14765	COG0110	maltose O-acetyltransferase activity
AM609_14790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM609_14840	COG2233	PERMEase
AM609_14905	COG0590	tRNA wobble adenosine to inosine editing
AM609_14905	COG0037	tRNA processing
AM609_14910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM609_14920	COG1136	(ABC) transporter
AM609_14920	COG0577	efflux transmembrane transporter activity
AM609_14955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AM609_14960	COG0561	phosphatase activity
AM609_14965	COG1653	transport
AM609_15000	COG0596	Alpha beta hydrolase
AM609_15010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM609_15045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AM609_15050	COG1132	(ABC) transporter
AM609_15055	COG1132	(ABC) transporter
AM609_15060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM609_15095	COG3189	MarR family transcriptional regulator
AM609_15100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM609_15110	COG0546	phosphoglycolate phosphatase activity
AM609_15195	COG2197	response regulator
AM609_15200	COG4585	Histidine kinase
AM609_15205	COG2197	response regulator
AM609_15220	COG3548	integral membrane protein
AM609_15225	COG2181	nitrate reductase activity
AM609_15225	COG0247	lactate metabolic process
AM609_15240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM609_15245	COG0470	DNA polymerase III
AM609_15265	COG0252	asparaginase activity
AM609_15280	COG0588	phosphoglycerate mutase activity
AM609_15285	COG0704	Plays a role in the regulation of phosphate uptake
AM609_15300	COG1329	Transcriptional regulator
AM609_15305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AM609_15320	COG2409	Drug exporters of the RND superfamily