locus-tag	class	description
HPC72_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPC72_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPC72_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPC72_00020	ENOG4105K7N	UPF0232 protein
HPC72_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPC72_00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPC72_00085	ENOG4108U4N	(sortase) family
HPC72_00095	ENOG4105D9P	serine threonine protein kinase
HPC72_00100	ENOG4107TPY	serine threonine protein kinase
HPC72_00105	ENOG4105CJN	penicillin-binding protein
HPC72_00120	ENOG4105HZM	Fha domain containing protein
HPC72_00125	ENOG4105TV9	FHA Domain-Containing protein
HPC72_00145	ENOG4105D22	carbon starvation protein
HPC72_00155	ENOG4107QTF	adenylosuccinate lyase
HPC72_00160	ENOG41082T9	Membrane
HPC72_00180	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPC72_00195	ENOG4105KME	endoribonuclease L-psp
HPC72_00210	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPC72_00220	ENOG4105C4Y	ABC transporter
HPC72_00225	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPC72_00230	ENOG4105BZU	Histidine kinase
HPC72_00275	ENOG4107TE5	Lipid kinase
HPC72_00280	ENOG4105C5Q	Transcriptional regulator
HPC72_00285	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPC72_00290	ENOG410667J	hydrolase
HPC72_00300	ENOG4107QKS	N-acylglucosamine 2-epimerase
HPC72_00325	ENOG4105C28	cystathionine
HPC72_00360	ENOG4105WH1	Two component transcriptional regulator luxr family
HPC72_00385	ENOG4105DF6	Fe-S oxidoreductase
HPC72_00405	ENOG4108UCS	ABC, transporter
HPC72_00495	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HPC72_00500	ENOG4105CFH	Aspartokinase
HPC72_00510	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPC72_00515	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPC72_00525	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPC72_00535	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HPC72_00540	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPC72_00545	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPC72_00550	ENOG4107JTW	chlorite dismutase
HPC72_00555	ENOG41080RH	Thioredoxin
HPC72_00655	ENOG4105EC2	ftsk spoIIIe
HPC72_00675	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPC72_00680	ENOG4105CC5	ABC transporter
HPC72_00690	ENOG4105DIK	(ABC) transporter
HPC72_00695	ENOG4107SIG	periplasmic solute binding protein
HPC72_00710	ENOG4107TE5	Lipid kinase
HPC72_00720	ENOG4108PSK	reductase
HPC72_00730	ENOG4105BZ4	penicillin-binding protein
HPC72_00745	ENOG4105IJJ	transcriptional regulator, crp fnr family
HPC72_00755	ENOG4105CPT	Alpha beta hydrolase
HPC72_00765	ENOG4108UMN	azlc family
HPC72_00815	ENOG4105D3R	alkyl hydroperoxide reductase
HPC72_00825	ENOG4105BZU	Histidine kinase
HPC72_00830	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPC72_00845	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPC72_00865	ENOG4105CSH	Transporter
HPC72_00885	ENOG4105DBV	ornithine carbamoyltransferase
HPC72_00890	ENOG4105CEU	Arginine dihydrolase
HPC72_00900	ENOG4107QRG	dna polymerase iii
HPC72_00910	ENOG4105HDK	L-asparaginase
HPC72_00930	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPC72_00940	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPC72_00950	ENOG4105K8R	UPF0145 protein
HPC72_00965	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HPC72_00975	ENOG4105CQ7	ATP-dependent helicase
HPC72_01005	ENOG4105EN6	Membrane
HPC72_01035	ENOG4108ZF3	Phosphatase
HPC72_01060	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPC72_01120	ENOG4105DHP	deoxycytidine triphosphate deaminase
HPC72_01145	ENOG4108DBC	nitroreductase
HPC72_01155	ENOG4105EMU	Dehydrogenase
HPC72_01165	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPC72_01185	ENOG4107RCW	fructose-bisphosphate aldolase
HPC72_01210	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPC72_01225	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
HPC72_01230	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPC72_01235	ENOG4105C8V	SAICAR synthetase
HPC72_01250	ENOG410839H	phosphoribosylformylglycinamidine synthase
HPC72_01255	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HPC72_01260	ENOG41088YS	Glycosyl transferase (Group 1
HPC72_01265	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPC72_01280	ENOG4105D82	Glutamate dehydrogenase
HPC72_01285	ENOG4105E98	transcriptional regulator DeoR family
HPC72_01290	ENOG4105DE4	1-phosphofructokinase
HPC72_01295	ENOG4105DM4	PTS System
HPC72_01305	ENOG4105JXH	GntR family transcriptional regulator
HPC72_01320	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPC72_01350	ENOG4105BZ1	(ABC) transporter
HPC72_01355	ENOG4105BZ1	(ABC) transporter
HPC72_01410	ENOG4107AQZ	Membrane
HPC72_01415	ENOG4105C1J	atp-dependent rna helicase
HPC72_01455	ENOG4107NHD	transcriptional regulator
HPC72_01465	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
HPC72_01480	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPC72_01510	ENOG4107RA4	Glycosyl transferase (Group 1
HPC72_01520	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HPC72_01565	ENOG4105K6V	RNA polymerase
HPC72_01575	ENOG4105R3P	Inner membrane protein yagU
HPC72_01580	ENOG4107SIQ	Naphthoate synthase
HPC72_01585	ENOG4105CEU	Arginine dihydrolase
HPC72_01595	ENOG4107TCW	O-succinylbenzoate synthase
HPC72_01600	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPC72_01615	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPC72_01620	ENOG4105P52	geranylgeranyl reductase
HPC72_01630	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HPC72_01635	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HPC72_01640	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HPC72_01650	ENOG4107QIZ	NADH dehydrogenase
HPC72_01655	ENOG4108IEH	NADH dehydrogenase subunit g
HPC72_01660	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HPC72_01665	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HPC72_01675	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HPC72_01680	ENOG4105D65	subunit l
HPC72_01690	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HPC72_01705	ENOG4105DSE	periplasmic solute binding protein
HPC72_01715	ENOG4105CC5	ABC transporter
HPC72_01720	ENOG4105FDK	ABC transporter
HPC72_01735	ENOG4105D0M	Protease HtpX homolog
HPC72_01740	ENOG4108VPT	UPF0234 protein
HPC72_01760	ENOG4105WDJ	50S ribosomal protein L33
HPC72_01775	ENOG4107WR6	Maf-like protein
HPC72_01780	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPC72_01790	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPC72_01795	ENOG4105BZU	Histidine kinase
HPC72_01805	ENOG4105DQR	SNARE associated Golgi
HPC72_01835	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_01865	ENOG4108KGH	TRANSCRIPTIONal
HPC72_01915	ENOG4105MFV	ABC-2 type transporter
HPC72_01920	ENOG4105EY8	ABC transporter
HPC72_01935	ENOG4105CTC	Lipopolysaccharide biosynthesis protein-like protein
HPC72_01955	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HPC72_01965	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HPC72_01970	ENOG4105KPE	licD family
HPC72_01975	ENOG4108SHN	Glycosyl transferase, family 2
HPC72_01985	ENOG4105KPE	licD family
HPC72_01990	ENOG4106MCE	EamA-like transporter family
HPC72_02005	ENOG4105EIP	mannose-6-phosphate isomerase
HPC72_02015	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
HPC72_02055	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPC72_02060	ENOG4108WQ6	secreted protein
HPC72_02075	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPC72_02080	ENOG4105BZU	Histidine kinase
HPC72_02090	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
HPC72_02095	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPC72_02100	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPC72_02140	ENOG4105C2J	ABC transporter
HPC72_02145	ENOG4105CNN	ABC, transporter
HPC72_02150	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPC72_02155	ENOG4105EYH	Exonuclease
HPC72_02160	ENOG4107RH8	nuclease SbcCD subunit D
HPC72_02165	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPC72_02170	ENOG4107TK4	histidinol-phosphate phosphatase
HPC72_02175	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPC72_02205	ENOG4108IUE	nitrate reductase beta subunit
HPC72_02220	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPC72_02230	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPC72_02240	ENOG4108ZAF	Molybdopterin
HPC72_02250	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPC72_02280	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPC72_02285	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HPC72_02300	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPC72_02305	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPC72_02310	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPC72_02320	ENOG4108ZF3	Phosphatase
HPC72_02330	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HPC72_02335	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPC72_02340	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPC72_02345	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPC72_02360	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPC72_02365	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPC72_02370	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPC72_02375	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPC72_02380	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPC72_02385	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPC72_02390	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPC72_02395	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPC72_02400	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HPC72_02405	ENOG41082SA	50s ribosomal protein l29
HPC72_02410	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HPC72_02420	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPC72_02425	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPC72_02430	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPC72_02435	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPC72_02440	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HPC72_02445	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HPC72_02455	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPC72_02460	ENOG410849U	50S ribosomal protein L30
HPC72_02465	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HPC72_02475	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPC72_02480	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPC72_02485	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPC72_02490	ENOG41067V7	50S ribosomal protein L36
HPC72_02495	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPC72_02500	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPC72_02505	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPC72_02510	ENOG4108ZT0	50S ribosomal protein l17
HPC72_02525	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPC72_02530	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPC72_02535	ENOG4108UJD	30S ribosomal protein S9
HPC72_02545	ENOG4105CS9	pantothenic acid kinase
HPC72_02560	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPC72_02565	ENOG4108097	ATP-binding protein
HPC72_02595	ENOG4105E33	succinate dehydrogenase
HPC72_02610	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPC72_02630	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPC72_02635	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPC72_02650	ENOG410849S	phosphocarrier protein (HPr)
HPC72_02655	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPC72_02660	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPC72_02675	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
HPC72_02685	ENOG4107P2S	Transcriptional regulator
HPC72_02695	ENOG4107QNK	)-transporter
HPC72_02705	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_02710	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_02720	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HPC72_02740	ENOG4105DH8	myo-inositol catabolism
HPC72_02745	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
HPC72_02755	ENOG4105C26	Dehydrogenase
HPC72_02765	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HPC72_02770	ENOG4105F0H	myo-inositol catabolism protein
HPC72_02775	ENOG4107QNK	)-transporter
HPC72_02795	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPC72_02805	ENOG4105WH1	Two component transcriptional regulator luxr family
HPC72_02810	ENOG4105CPC	Aldo Keto reductase
HPC72_02840	ENOG4105WH1	Two component transcriptional regulator luxr family
HPC72_02855	ENOG4105ESV	Glycosyl transferase, family 4
HPC72_02865	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPC72_02870	ENOG4105ZA1	atp synthase
HPC72_02875	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HPC72_02880	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPC72_02885	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPC72_02890	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPC72_02895	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPC72_02925	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
HPC72_02940	ENOG4105CE4	GlcNAc 6-P deacetylase
HPC72_02955	ENOG4106032	Glutathionylspermidine synthase
HPC72_02965	ENOG4108638	50S ribosomal protein L36
HPC72_02970	ENOG4105NRA	50s ribosomal protein l31 type b
HPC72_02975	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPC72_02980	ENOG4105W0E	50S ribosomal protein L33
HPC72_02985	ENOG4105KDC	50s ribosomal protein l28
HPC72_02995	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPC72_03010	ENOG4105CGK	Exodeoxyribonuclease III
HPC72_03020	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPC72_03035	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HPC72_03045	ENOG4107SIG	periplasmic solute binding protein
HPC72_03050	ENOG4105D5T	phosphonate abc transporter
HPC72_03055	ENOG4105CC5	ABC transporter
HPC72_03065	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HPC72_03070	ENOG4108URH	decarboxylase
HPC72_03085	ENOG4105UTW	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPC72_03100	ENOG4105CJW	magnesium transporter
HPC72_03115	ENOG4105PGM	cation diffusion facilitator family transporter
HPC72_03140	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPC72_03145	ENOG4105C1J	atp-dependent rna helicase
HPC72_03215	ENOG4105C5Q	Transcriptional regulator
HPC72_03220	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HPC72_03240	ENOG4105BZ1	(ABC) transporter
HPC72_03250	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HPC72_03265	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
HPC72_03295	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPC72_03300	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
HPC72_03310	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HPC72_03315	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPC72_03330	ENOG4105BZJ	Electron transfer flavoprotein
HPC72_03335	ENOG4105C10	Electron transfer flavoprotein
HPC72_03340	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPC72_03365	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HPC72_03405	ENOG4105DET	Rhamnulokinase
HPC72_03410	ENOG41063PX	domain protein
HPC72_03425	ENOG4105DJZ	UPF0182 protein
HPC72_03560	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPC72_03570	ENOG4107QJE	Chromosome Partitioning Protein
HPC72_03590	ENOG4105C9Q	fumarate hydratase class II
HPC72_03595	ENOG4108IJ8	ABC transporter
HPC72_03615	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_03620	ENOG4105CK5	oxidoreductase
HPC72_03625	ENOG4107TTA	Xylose isomerase domain protein TIM barrel
HPC72_03630	ENOG4107QNK	)-transporter
HPC72_03640	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HPC72_03645	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HPC72_03680	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPC72_03690	ENOG4108IUX	(ABC) transporter
HPC72_03700	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HPC72_03705	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPC72_03710	ENOG4107TXC	Transcriptional regulator
HPC72_03720	ENOG4108S01	response regulator
HPC72_03725	ENOG4105BZU	Histidine kinase
HPC72_03735	ENOG4108M15	ABC transporter
HPC72_03740	ENOG4105BZG	amino acid carrier protein
HPC72_03745	ENOG4105K5M	30s ribosomal protein S16
HPC72_03750	ENOG41082KU	UPF0109 protein
HPC72_03755	ENOG4105CPC	Aldo Keto reductase
HPC72_03760	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPC72_03765	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPC72_03770	ENOG4107QYR	Signal peptidase i
HPC72_03780	ENOG4107QYR	Signal peptidase i
HPC72_03785	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPC72_03795	ENOG4105VFF	UPF0102 protein
HPC72_03810	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPC72_03820	ENOG4105CE9	30S ribosomal protein S2
HPC72_03825	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HPC72_03840	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPC72_03845	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPC72_03850	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPC72_03855	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HPC72_03865	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPC72_03870	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPC72_03880	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPC72_03890	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPC72_03900	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
HPC72_03915	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPC72_03950	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HPC72_03960	ENOG4105E8G	Major facilitator Superfamily
HPC72_03985	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HPC72_03990	ENOG4105C1V	Peptidase, M16
HPC72_03995	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPC72_04005	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HPC72_04015	ENOG4105CEY	Amp-dependent synthetase and ligase
HPC72_04045	ENOG4108V6E	Cell division protein mraZ
HPC72_04050	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HPC72_04060	ENOG4105CJN	penicillin-binding protein
HPC72_04065	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPC72_04075	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HPC72_04080	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPC72_04085	ENOG4105CNI	cell division protein FtsW
HPC72_04090	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HPC72_04095	ENOG4105DFU	Cell wall formation (By similarity)
HPC72_04105	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPC72_04110	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPC72_04115	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
HPC72_04125	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
HPC72_04145	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPC72_04150	ENOG410848D	S4 domain protein YaaA
HPC72_04170	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPC72_04185	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPC72_04200	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPC72_04210	ENOG4105EEQ	Na H antiporter
HPC72_04215	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPC72_04220	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPC72_04235	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HPC72_04240	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPC72_04260	ENOG4105DPH	UPF0371 protein
HPC72_04265	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HPC72_04280	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPC72_04290	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPC72_04295	ENOG4105DDQ	anthranilate synthase
HPC72_04300	ENOG4105CRQ	synthase (Component I)
HPC72_04305	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPC72_04315	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPC72_04325	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HPC72_04330	ENOG4105DJ2	Major Facilitator Superfamily
HPC72_04340	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPC72_04355	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HPC72_04360	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPC72_04365	ENOG4105DFA	alanine racemase domain protein
HPC72_04370	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HPC72_04380	ENOG4105CIG	ABC transporter
HPC72_04400	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HPC72_04410	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPC72_04420	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HPC72_04425	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
HPC72_04430	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPC72_04435	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
HPC72_04440	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPC72_04450	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HPC72_04480	ENOG4105EAC	phosphoserine phosphatase
HPC72_04485	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPC72_04490	ENOG4107QPH	glycogen) synthase
HPC72_04505	ENOG4105DKW	ABC transporter
HPC72_04530	ENOG4105C5H	ABC transporter
HPC72_04575	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HPC72_04595	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPC72_04620	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPC72_04630	ENOG4105CD3	dihydroorotase
HPC72_04675	ENOG4107VEG	TrkA-N domain protein
HPC72_04680	ENOG4105C0X	amino acid
HPC72_04685	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HPC72_04690	ENOG4107QM5	aconitate hydratase
HPC72_04695	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPC72_04700	ENOG4105EMU	Dehydrogenase
HPC72_04705	ENOG4108V1U	phospholipid-binding protein
HPC72_04725	ENOG4108IQI	permease
HPC72_04730	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPC72_04740	ENOG4105DSB	aldose 1-epimerase
HPC72_04760	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPC72_04770	ENOG4105CPC	Aldo Keto reductase
HPC72_04780	ENOG4105CUC	YeeE YedE family protein
HPC72_04800	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPC72_04810	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
HPC72_04825	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
HPC72_04835	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPC72_04855	ENOG4105EPD	Oligopeptide transporter, Opt family
HPC72_04860	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPC72_04865	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPC72_04895	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPC72_04905	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPC72_04910	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HPC72_04940	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPC72_04955	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPC72_04960	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
HPC72_04965	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
HPC72_04995	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPC72_05000	ENOG4105C5Y	PTS System
HPC72_05010	ENOG4105CID	antiterminator
HPC72_05015	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPC72_05025	ENOG4105CIE	May be required for sporulation (By similarity)
HPC72_05030	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPC72_05035	ENOG4105BZA	Phosphoglycerate kinase
HPC72_05040	ENOG4105CP7	Triose-phosphate isomerase
HPC72_05060	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HPC72_05065	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HPC72_05080	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPC72_05090	ENOG4107QP8	phosphohexose isomerase
HPC72_05115	ENOG4105DB4	
HPC72_05125	ENOG41067SE	Tetr family transcriptional regulator
HPC72_05135	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
HPC72_05170	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPC72_05175	ENOG4108UW8	fha domain-containing protein
HPC72_05195	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPC72_05200	ENOG4105C5Y	PTS System
HPC72_05205	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_05230	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HPC72_05245	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPC72_05250	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPC72_05270	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
HPC72_05275	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPC72_05280	ENOG4107XKF	NMT1 THI5 Like Domain Protein
HPC72_05285	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
HPC72_05295	ENOG4108RWI	nicotinamidase
HPC72_05305	ENOG4105CK7	Sodium proline symporter
HPC72_05315	ENOG4105D8K	carboxyl transferase
HPC72_05320	ENOG4108JIK	carboxylase
HPC72_05330	ENOG4105DA5	(ABC) transporter
HPC72_05335	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPC72_05345	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HPC72_05365	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HPC72_05375	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HPC72_05385	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPC72_05395	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HPC72_05400	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPC72_05410	ENOG4105CD3	dihydroorotase
HPC72_05415	ENOG4105CXT	aspartate transcarbamylase
HPC72_05420	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HPC72_05430	ENOG410803B	Involved in the transcription termination process (By similarity)
HPC72_05435	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPC72_05445	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPC72_05450	ENOG4105D49	3-dehydroquinate synthase
HPC72_05455	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPC72_05460	ENOG4105E2X	shikimate dehydrogenase
HPC72_05470	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPC72_05475	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPC72_05480	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPC72_05485	ENOG4105HF0	Membrane
HPC72_05495	ENOG4107R13	MMPL domain protein
HPC72_05500	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPC72_05505	ENOG41080HT	Transcriptional regulator, arsr family
HPC72_05515	ENOG4105C9M	aspartyl-trna synthetase
HPC72_05545	ENOG4105CUT	histidyl-tRNA synthetase
HPC72_05565	ENOG4105C99	atpase involved in dna repair
HPC72_05575	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPC72_05580	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPC72_05585	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPC72_05590	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPC72_05600	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HPC72_05605	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPC72_05610	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPC72_05615	ENOG4105CDY	transcriptional regulatory protein
HPC72_05620	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPC72_05635	ENOG4105E2K	Glycosyl transferase (Group 1
HPC72_05640	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
HPC72_05655	ENOG4105C22	threonyL-tRNA synthetase
HPC72_05665	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPC72_05715	ENOG4105C6N	Formate acetyltransferase
HPC72_05740	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPC72_05760	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HPC72_05765	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPC72_05775	ENOG4105C5F	glutamine synthetase
HPC72_05785	ENOG4105E5Q	amino acid AbC transporter
HPC72_05790	ENOG4108JEH	abc transporter atp-binding protein
HPC72_05800	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPC72_05805	ENOG4105C5F	glutamine synthetase
HPC72_05810	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPC72_05835	ENOG4107XFJ	UPF0246 protein
HPC72_05845	ENOG4105EGD	dinuclear metal center protein, YbgI family
HPC72_05885	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPC72_05890	ENOG4108IJ0	Aspartate ammonia-lyase
HPC72_05900	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPC72_05915	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPC72_05960	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPC72_05965	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPC72_05980	ENOG4105BZW	Glycerate kinase
HPC72_05985	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HPC72_05995	ENOG4105CPC	Aldo Keto reductase
HPC72_06000	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPC72_06015	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPC72_06030	ENOG4105CIG	ABC transporter
HPC72_06040	ENOG4105VG1	fes assembly suf system protein
HPC72_06045	ENOG4107YH3	SUF system FeS assembly protein, NifU family
HPC72_06055	ENOG4105C3K	feS assembly ATPase SufC
HPC72_06065	ENOG4105DIW	FeS assembly protein SUFB
HPC72_06080	ENOG4105ECY	inositol monophosphatase
HPC72_06110	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPC72_06115	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPC72_06130	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HPC72_06160	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPC72_06165	ENOG4105YXB	Toxic component of a toxin-antitoxin (TA) module. A
HPC72_06180	ENOG4108VX5	3-methyladenine DNA glycosylase
HPC72_06185	ENOG4105CH7	arginosuccinase
HPC72_06195	ENOG4105CDH	Citrulline--aspartate ligase
HPC72_06200	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HPC72_06205	ENOG4105C8Y	Acetylornithine aminotransferase
HPC72_06210	ENOG4105CAS	nag kinase
HPC72_06215	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HPC72_06220	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPC72_06230	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HPC72_06235	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPC72_06245	ENOG4105DRP	amino acid AbC transporter
HPC72_06250	ENOG4105EAD	ABC transporter
HPC72_06255	ENOG4107RP9	extracellular solute-binding protein, family 3
HPC72_06260	ENOG4105CDA	abc transporter atp-binding protein
HPC72_06265	ENOG4108RWN	rrna methyltransferase
HPC72_06270	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPC72_06275	ENOG41084BS	50S ribosomal protein L35
HPC72_06280	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPC72_06295	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HPC72_06305	ENOG4105EPR	degv family
HPC72_06310	ENOG4105D7A	ATP-binding protein
HPC72_06315	ENOG4105C8T	Leucyl-tRNA synthetase
HPC72_06320	ENOG4107ZUX	Histidine triad (HIT) protein
HPC72_06350	ENOG4105C8J	)-transporter
HPC72_06375	ENOG4107TB6	phosphoglycerate mutase
HPC72_06390	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HPC72_06395	ENOG4105E98	transcriptional regulator DeoR family
HPC72_06400	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPC72_06410	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPC72_06415	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPC72_06420	ENOG4105K46	50S ribosomal protein l27
HPC72_06425	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPC72_06435	ENOG4105CRE	cytochrome C
HPC72_06445	ENOG4107QIV	Cytochrome c biogenesis protein
HPC72_06460	ENOG4108W6G	cytochrome C
HPC72_06465	ENOG4105C03	ribonuclease
HPC72_06470	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPC72_06475	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPC72_06480	ENOG4108JJ9	ABC, transporter
HPC72_06485	ENOG4108JJ8	(ABC) transporter
HPC72_06500	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPC72_06505	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPC72_06520	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPC72_06535	ENOG4105DP4	dak2 domain fusion protein ylov
HPC72_06540	ENOG4105VB9	50S ribosomal protein l28
HPC72_06550	ENOG4105CPF	Cell wall formation (By similarity)
HPC72_06565	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPC72_06575	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPC72_06580	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPC72_06585	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPC72_06600	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPC72_06610	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPC72_06625	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPC72_06635	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPC72_06645	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPC72_06650	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPC72_06655	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPC72_06680	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPC72_06700	ENOG4107SJW	iron permease, FTR1
HPC72_06710	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HPC72_06715	ENOG4105E2R	ROK family
HPC72_06730	ENOG4105DRS	transport system, permease
HPC72_06740	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HPC72_06745	ENOG4105KC9	Modulates RecA activity (By similarity)
HPC72_06750	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPC72_06760	ENOG4105WBV	Transcriptional regulator
HPC72_06765	ENOG4105CEV	competence damage-inducible protein
HPC72_06775	ENOG4107QZI	cell division protein FtsK
HPC72_06785	ENOG4105CN5	Metallo-Beta-Lactamase
HPC72_06820	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPC72_06830	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HPC72_06835	ENOG4105BZG	amino acid carrier protein
HPC72_06860	ENOG4107QK5	Homocysteine s-methyltransferase
HPC72_06865	ENOG4108IQI	permease
HPC72_06870	ENOG410901E	Membrane
HPC72_06910	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPC72_06915	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HPC72_06930	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPC72_06940	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPC72_06960	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPC72_06970	ENOG4105CJ1	ABC, transporter
HPC72_06975	ENOG4108426	dNA-binding protein
HPC72_06980	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
HPC72_06985	ENOG4105DKQ	ROK family
HPC72_06990	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HPC72_06995	ENOG4108JQ7	(ABC) transporter
HPC72_07010	ENOG4108J59	Extracellular solute-binding protein, family 5
HPC72_07015	ENOG4105FDP	GntR family transcriptional regulator
HPC72_07030	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPC72_07040	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
HPC72_07045	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPC72_07055	ENOG4107YH6	single-stranded DNA-binding protein
HPC72_07075	ENOG4105IDI	abc transporter atp-binding protein
HPC72_07080	ENOG4108UGD	Serine Threonine protein kinase
HPC72_07085	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPC72_07095	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HPC72_07105	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HPC72_07150	ENOG4105K64	Glycosyl transferase, family 2
HPC72_07155	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
HPC72_07165	ENOG4108KGH	TRANSCRIPTIONal
HPC72_07175	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPC72_07180	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPC72_07185	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HPC72_07200	ENOG4105D0C	transport protein
HPC72_07205	ENOG4105DWK	Membrane
HPC72_07210	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_07215	ENOG4105D7K	pfkb domain protein
HPC72_07220	ENOG4105DRS	transport system, permease
HPC72_07225	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HPC72_07255	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HPC72_07260	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HPC72_07265	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HPC72_07275	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HPC72_07280	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPC72_07285	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HPC72_07295	ENOG4107YJ4	chain length determinant protein
HPC72_07305	ENOG4108UW5	maltose o-acetyltransferase
HPC72_07315	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HPC72_07330	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HPC72_07335	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HPC72_07340	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPC72_07355	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPC72_07360	ENOG410635A	Membrane
HPC72_07375	ENOG4105II7	pyrroline-5-carboxylate reductase
HPC72_07380	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
HPC72_07385	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
HPC72_07395	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
HPC72_07400	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPC72_07405	ENOG4108IQE	Amp-dependent synthetase and ligase
HPC72_07415	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
HPC72_07420	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPC72_07425	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPC72_07430	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPC72_07460	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPC72_07515	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
HPC72_07565	ENOG4108RCM	Nitroreductase
HPC72_07585	ENOG41067C8	50S ribosomal protein L32
HPC72_07590	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPC72_07600	ENOG4105D7W	serine acetyltransferase
HPC72_07610	ENOG4105BZW	Glycerate kinase
HPC72_07615	ENOG4108YZG	isomerase
HPC72_07620	ENOG4105C9K	Endothelin-converting enzyme 1
HPC72_07640	ENOG4105FDP	GntR family transcriptional regulator
HPC72_07650	ENOG4105C5Y	PTS System
HPC72_07665	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPC72_07670	ENOG4105C29	acyl-CoA thioesterase
HPC72_07695	ENOG4105CTQ	phosphohexokinase
HPC72_07710	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPC72_07735	ENOG4105E2R	ROK family
HPC72_07800	ENOG4105E0A	ABC, transporter
HPC72_07815	ENOG4105FDP	GntR family transcriptional regulator
HPC72_07840	ENOG4108M15	ABC transporter
HPC72_07845	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPC72_07850	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPC72_07855	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPC72_07875	ENOG4108PJD	permease
HPC72_07885	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPC72_07890	ENOG4105D6E	homoserine dehydrogenase
HPC72_07895	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPC72_07900	ENOG4105C75	arginyL-tRNA synthetase
HPC72_07920	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
HPC72_07935	ENOG4105C37	(CBS) domain
HPC72_07940	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPC72_07960	ENOG4105WMN	AntiSigma factor
HPC72_07965	ENOG4105EMN	RNA polymerase sigma factor
HPC72_07985	ENOG4105E9K	Isocitrate dehydrogenase
HPC72_07990	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HPC72_07995	ENOG4108VZM	50s ribosomal protein L10
HPC72_08000	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HPC72_08005	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HPC72_08010	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPC72_08030	ENOG4105XTG	Pfam:DUF156
HPC72_08050	ENOG4107R4N	Cell wall formation (By similarity)
HPC72_08065	ENOG4105CZN	Potassium uptake protein
HPC72_08075	ENOG4107WI4	Aldose-1-epimerase
HPC72_08080	ENOG4105VDH	Dihydroxyacetone kinase
HPC72_08090	ENOG4105CMT	Dihydroxyacetone kinase
HPC72_08115	ENOG4105H6Q	decarboxylase
HPC72_08130	ENOG4108IPW	abc transporter atp-binding protein
HPC72_08135	ENOG4105CM4	permease protein
HPC72_08150	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPC72_08155	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
HPC72_08175	ENOG4105DKT	Transcriptional regulator
HPC72_08180	ENOG4105EF1	ribulokinase
HPC72_08190	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
HPC72_08195	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HPC72_08205	ENOG4107YVI	ribose 5-phosphate isomerase
HPC72_08215	ENOG4105DKT	Transcriptional regulator
HPC72_08220	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPC72_08225	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPC72_08230	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HPC72_08240	ENOG4105C59	p-type ATPase
HPC72_08245	ENOG4105DAA	L-lactate
HPC72_08250	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPC72_08260	ENOG41080R8	Conserved Protein
HPC72_08275	ENOG4105DEI	Mannitol dehydrogenase
HPC72_08285	ENOG4105DUX	Transporter
HPC72_08290	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPC72_08305	ENOG4105C26	Dehydrogenase
HPC72_08320	ENOG4105D82	Glutamate dehydrogenase
HPC72_08335	ENOG4105CRK	lysyL-tRNA synthetase
HPC72_08350	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPC72_08380	ENOG4105EEI	dihydropteroate synthase
HPC72_08385	ENOG4105EUJ	GTP cyclohydrolase i
HPC72_08390	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPC72_08430	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPC72_08445	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPC72_08450	ENOG4107SN7	NLP P60 protein
HPC72_08455	ENOG4108IQK	o-acetylhomoserine
HPC72_08460	ENOG4105DWV	Homoserine O-trans-acetylase
HPC72_08485	ENOG4108RH7	phosphoglycerate mutase
HPC72_08505	ENOG4108Z4U	Ferredoxin
HPC72_08515	ENOG4105CI3	gtp-binding protein typa
HPC72_08525	ENOG4105DEN	Luciferase family
HPC72_08530	ENOG4105VKD	bioY protein
HPC72_08550	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPC72_08555	ENOG4105K5B	UPF0225 protein
HPC72_08560	ENOG4105DFM	M18 family aminopeptidase
HPC72_08625	ENOG4106178	UPF0339 protein
HPC72_08635	ENOG4105DA5	(ABC) transporter
HPC72_08650	ENOG4107WD8	ABC transporter, permease
HPC72_08660	ENOG4105C3G	gtp-binding protein
HPC72_08675	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPC72_08680	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPC72_08685	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPC72_08690	ENOG4105D7K	pfkb domain protein
HPC72_08695	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPC72_08705	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPC72_08710	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPC72_08725	ENOG4108YYH	Nadph-dependent fmn reductase
HPC72_08730	ENOG4108YYH	Nadph-dependent fmn reductase
HPC72_08740	ENOG4105C7B	Threonine dehydratase
HPC72_08745	ENOG4105C01	Dihydroxy-acid dehydratase
HPC72_08750	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPC72_08760	ENOG4105CJ1	ABC, transporter
HPC72_08770	ENOG4105BZU	Histidine kinase
HPC72_08775	ENOG4105WH1	Two component transcriptional regulator luxr family
HPC72_08780	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPC72_08785	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPC72_08790	ENOG4105FF2	Type I DHQase
HPC72_08810	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPC72_08840	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPC72_08845	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPC72_08900	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPC72_08920	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HPC72_08960	ENOG4107TPY	serine threonine protein kinase
HPC72_08970	ENOG4105C5H	ABC transporter
HPC72_08975	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPC72_08980	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HPC72_09000	ENOG4105F8V	Hydrolase, tatD family
HPC72_09005	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPC72_09055	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
HPC72_09065	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HPC72_09115	ENOG4105C7N	Xanthine uracil vitamin C permease
HPC72_09145	ENOG4105CFI	type iii restriction protein res subunit
HPC72_09170	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPC72_09175	ENOG4105EB3	Histidine kinase
HPC72_09190	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPC72_09205	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPC72_09215	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPC72_09220	ENOG4105E2R	ROK family
HPC72_09225	ENOG4105C93	Xylose Isomerase
HPC72_09245	ENOG4108HWW	ABC transporter
HPC72_09280	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPC72_09285	ENOG4105C8N	cysteinyl-tRNA synthetase
HPC72_09290	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPC72_09330	ENOG4105F3R	pts system mannose fructose sorbose family iid
HPC72_09335	ENOG4105ETZ	PTS System
HPC72_09340	ENOG4105DAS	pts system
HPC72_09355	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_09360	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HPC72_09370	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPC72_09405	ENOG4105CRK	lysyL-tRNA synthetase
HPC72_09415	ENOG4105F44	Two component transcriptional regulator, winged helix family
HPC72_09420	ENOG4106F60	Histidine kinase
HPC72_09425	ENOG4105KNI	merR family transcriptional Regulator
HPC72_09430	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPC72_09435	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPC72_09440	ENOG4105CFG	Acts as a chaperone (By similarity)
HPC72_09455	ENOG4105C2W	permease
HPC72_09480	ENOG4105CQ7	ATP-dependent helicase
HPC72_09495	ENOG4108UW5	maltose o-acetyltransferase
HPC72_09500	ENOG4108Z6B	deaminase
HPC72_09505	ENOG4105C94	Transporter
HPC72_09510	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HPC72_09515	ENOG4105D01	(LipO)protein
HPC72_09520	ENOG4108UMI	ABC transporter, permease
HPC72_09525	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HPC72_09535	ENOG4105KJF	protein tyrosine phosphatase
HPC72_09550	ENOG4108RVA	ribokinase
HPC72_09575	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPC72_09580	ENOG4105CNT	hydrolase family 2
HPC72_09585	ENOG4105ETE	Transcriptional regulator (LacI family
HPC72_09610	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPC72_09615	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
HPC72_09650	ENOG4107QW3	Sucrose phosphorylase
HPC72_09665	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HPC72_09680	ENOG4105DSF	transport protein
HPC72_09685	ENOG4105EV9	Alpha Beta Hydrolase
HPC72_09690	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPC72_09700	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPC72_09720	ENOG4107WGA	YidE YbjL
HPC72_09745	ENOG4105C85	amino acid
HPC72_09755	ENOG4105WMR	Protein CrcB homolog
HPC72_09760	ENOG41083TI	Protein CrcB homolog
HPC72_09770	ENOG4105DKQ	ROK family
HPC72_09780	ENOG4105DQ5	transport system permease protein
HPC72_09785	ENOG4105TVJ	transport system, permease
HPC72_09790	ENOG4105E0A	ABC, transporter
HPC72_09800	ENOG4105CDU	Replicative dna helicase
HPC72_09810	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPC72_09815	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPC72_09820	ENOG4107YH6	single-stranded DNA-binding protein
HPC72_09825	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPC72_09830	ENOG4105BZ4	penicillin-binding protein
HPC72_09850	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HPC72_09855	ENOG41060W2	glyoxylate carboligase
HPC72_09865	ENOG4108IUS	Transketolase
HPC72_09870	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPC72_09880	ENOG4105CXT	aspartate transcarbamylase
HPC72_09890	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HPC72_09900	ENOG410633P	Hydantoin racemase
HPC72_09920	ENOG4108JQ1	Dehydrogenase
HPC72_09925	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPC72_09930	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HPC72_09950	ENOG4105C3M	thioredoxin reductase
HPC72_09955	ENOG4105K63	Thioredoxin
HPC72_09965	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPC72_09970	ENOG4105CPF	Cell wall formation (By similarity)
HPC72_09985	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPC72_09995	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPC72_10000	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HPC72_10010	ENOG41084CH	50S ribosomal protein l34