locus-tag	class	description
HPC72_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPC72_00010	COG0592	DNA-directed DNA polymerase activity
HPC72_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPC72_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HPC72_00025	COG0187	DNA topoisomerase II activity
HPC72_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPC72_00085	COG3764	Sortase (surface protein transpeptidase)
HPC72_00095	COG2815	serine threonine protein kinase
HPC72_00095	COG0515	serine threonine protein kinase
HPC72_00100	COG0515	serine threonine protein kinase
HPC72_00105	COG0768	penicillin binding
HPC72_00120	COG1716	ATPase activity
HPC72_00125	COG1716	ATPase activity
HPC72_00145	COG1966	Carbon starvation protein
HPC72_00155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPC72_00160	COG1950	PFAM Membrane protein of
HPC72_00180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPC72_00210	COG3842	ATPase activity
HPC72_00215	COG1178	ABC-type Fe3 transport system permease component
HPC72_00220	COG1840	ABC-type Fe3 transport system, periplasmic component
HPC72_00230	COG5002	protein histidine kinase activity
HPC72_00235	COG3588	fructose-bisphosphate aldolase
HPC72_00285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPC72_00290	COG0561	phosphatase activity
HPC72_00325	COG0626	cystathionine gamma-synthase activity
HPC72_00360	COG2197	response regulator
HPC72_00370	COG1131	(ABC) transporter
HPC72_00385	COG2181	nitrate reductase activity
HPC72_00385	COG0247	lactate metabolic process
HPC72_00405	COG3842	ATPase activity
HPC72_00495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPC72_00510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPC72_00515	COG0113	porphobilinogen synthase activity
HPC72_00525	COG0181	hydroxymethylbilane synthase activity
HPC72_00535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPC72_00540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPC72_00555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPC72_00560	COG0783	Belongs to the Dps family
HPC72_00655	COG1674	ftsk spoiiie
HPC72_00675	COG1051	belongs to the nudix hydrolase family
HPC72_00680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPC72_00690	COG1121	(ABC) transporter
HPC72_00695	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPC72_00710	COG1597	lipid kinase activity
HPC72_00720	COG1028	Short-chain dehydrogenase reductase Sdr
HPC72_00730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPC72_00745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPC72_00755	COG0596	Alpha beta hydrolase
HPC72_00765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPC72_00815	COG0450	alkyl hydroperoxide reductase
HPC72_00825	COG2205	protein histidine kinase activity
HPC72_00830	COG0745	RESPONSE REGULATOR receiver
HPC72_00845	COG1754	DNA topoisomerase type I activity
HPC72_00845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPC72_00880	COG0549	Belongs to the carbamate kinase family
HPC72_00885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPC72_00890	COG2235	arginine
HPC72_00900	COG0470	DNA polymerase III
HPC72_00910	COG0252	asparaginase activity
HPC72_00915	COG1113	amino acid transport
HPC72_00930	COG0588	phosphoglycerate mutase activity
HPC72_00940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPC72_00950	COG0393	Putative heavy-metal-binding
HPC72_00965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPC72_00975	COG1643	Atp-dependent helicase
HPC72_01000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPC72_01005	COG2860	membrane
HPC72_01035	COG0631	protein serine/threonine phosphatase activity
HPC72_01060	COG0714	Associated with various cellular activities
HPC72_01120	COG0717	Belongs to the dCTP deaminase family
HPC72_01145	COG0778	Nitroreductase
HPC72_01155	COG4221	oxidoreductase activity
HPC72_01165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPC72_01180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPC72_01185	COG0191	fructose-bisphosphate aldolase activity
HPC72_01210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPC72_01225	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HPC72_01230	COG0151	Belongs to the GarS family
HPC72_01235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPC72_01250	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPC72_01255	COG0047	phosphoribosylformylglycinamidine synthase activity
HPC72_01260	COG0438	transferase activity, transferring glycosyl groups
HPC72_01265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPC72_01280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPC72_01285	COG1349	DNA-binding transcription factor activity
HPC72_01290	COG1105	Belongs to the carbohydrate kinase PfkB family
HPC72_01295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPC72_01295	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPC72_01295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPC72_01305	COG2186	Transcriptional regulator
HPC72_01320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPC72_01350	COG1132	(ABC) transporter
HPC72_01410	COG5006	permease, DMT superfamily
HPC72_01415	COG0513	Belongs to the DEAD box helicase family
HPC72_01455	COG0745	RESPONSE REGULATOR receiver
HPC72_01465	COG3485	protocatechuate 3,4-dioxygenase
HPC72_01480	COG1490	D-aminoacyl-tRNA deacylase activity
HPC72_01510	COG0438	transferase activity, transferring glycosyl groups
HPC72_01510	COG0297	glycogen (starch) synthase activity
HPC72_01520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPC72_01520	COG0574	Belongs to the PEP-utilizing enzyme family
HPC72_01565	COG1595	DNA-templated transcription, initiation
HPC72_01575	COG3477	response to acidic pH
HPC72_01580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPC72_01585	COG2235	arginine
HPC72_01595	COG4948	Mandelate Racemase Muconate Lactonizing
HPC72_01600	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPC72_01615	COG2226	methyltransferase
HPC72_01620	COG0644	oxidoreductase
HPC72_01630	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC72_01635	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC72_01640	COG0649	NAD binding
HPC72_01650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HPC72_01655	COG1034	ATP synthesis coupled electron transport
HPC72_01660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPC72_01675	COG0713	ATP synthesis coupled electron transport
HPC72_01680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPC72_01690	COG1007	ATP synthesis coupled electron transport
HPC72_01720	COG1121	(ABC) transporter
HPC72_01735	COG0501	Belongs to the peptidase M48B family
HPC72_01740	COG1666	GTP binding
HPC72_01760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPC72_01775	COG0424	maF-like protein
HPC72_01780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPC72_01780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPC72_01790	COG0745	RESPONSE REGULATOR receiver
HPC72_01795	COG5002	protein histidine kinase activity
HPC72_01805	COG0586	Pfam SNARE associated Golgi protein
HPC72_01855	COG1175	transmembrane transport
HPC72_01860	COG0395	ABC-type sugar transport system, permease component
HPC72_01865	COG1316	TRANSCRIPTIONal
HPC72_01935	COG3754	Rhamnan synthesis protein F
HPC72_01955	COG1216	Glycosyl transferase, family 2
HPC72_01965	COG0438	transferase activity, transferring glycosyl groups
HPC72_01970	COG3475	LICD family
HPC72_01975	COG1215	transferase activity, transferring glycosyl groups
HPC72_01985	COG3475	LICD family
HPC72_01990	COG0697	spore germination
HPC72_01995	COG4750	Nucleotidyl transferase
HPC72_02005	COG1482	cell wall glycoprotein biosynthetic process
HPC72_02055	COG0714	Associated with various cellular activities
HPC72_02075	COG0745	RESPONSE REGULATOR receiver
HPC72_02080	COG5002	protein histidine kinase activity
HPC72_02090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPC72_02095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPC72_02100	COG0653	protein targeting
HPC72_02140	COG1129	ABC transporter
HPC72_02145	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPC72_02150	COG1879	ABC-type sugar transport system periplasmic component
HPC72_02155	COG0419	ATPase involved in DNA repair
HPC72_02160	COG0420	3'-5' exonuclease activity
HPC72_02165	COG1968	undecaprenyl-diphosphatase activity
HPC72_02170	COG0483	inositol monophosphate 1-phosphatase activity
HPC72_02175	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPC72_02205	COG1140	nitrate reductase beta subunit
HPC72_02220	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPC72_02220	COG0315	cyclic pyranopterin monophosphate synthase activity
HPC72_02230	COG0315	cyclic pyranopterin monophosphate synthase activity
HPC72_02240	COG0314	molybdopterin synthase activity
HPC72_02250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPC72_02280	COG1162	GTPase activity
HPC72_02285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPC72_02300	COG0085	RNA polymerase activity
HPC72_02305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPC72_02310	COG0714	Associated with various cellular activities
HPC72_02320	COG0631	protein serine/threonine phosphatase activity
HPC72_02330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPC72_02335	COG0049	tRNA binding
HPC72_02340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPC72_02345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPC72_02360	COG0051	transcription antitermination factor activity, RNA binding
HPC72_02370	COG0088	Forms part of the polypeptide exit tunnel
HPC72_02375	COG0089	rRNA binding
HPC72_02380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPC72_02385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPC72_02390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPC72_02395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPC72_02400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPC72_02405	COG0255	Belongs to the universal ribosomal protein uL29 family
HPC72_02410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPC72_02420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPC72_02425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPC72_02430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPC72_02435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPC72_02440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPC72_02445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPC72_02455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPC72_02460	COG1841	ribosomal large subunit assembly
HPC72_02465	COG0200	Binds to the 23S rRNA
HPC72_02475	COG0563	adenylate kinase activity
HPC72_02480	COG0024	Methionine aminopeptidase
HPC72_02485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPC72_02490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPC72_02495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPC72_02500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPC72_02505	COG0202	RNA polymerase activity
HPC72_02510	COG0203	ribosomal protein L17
HPC72_02525	COG0101	tRNA pseudouridine synthase activity
HPC72_02530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPC72_02535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPC72_02545	COG1072	(Pantothenic acid kinase))
HPC72_02560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPC72_02565	COG0802	atpase or kinase
HPC72_02590	COG1053	succinate dehydrogenase
HPC72_02595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPC72_02610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPC72_02630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPC72_02645	COG0516	GMP reductase activity
HPC72_02650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPC72_02655	COG0328	RNA-DNA hybrid ribonuclease activity
HPC72_02660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPC72_02675	COG1082	Xylose isomerase domain protein TIM barrel
HPC72_02685	COG1609	Transcriptional regulator
HPC72_02690	COG1082	Xylose isomerase domain protein TIM barrel
HPC72_02695	COG2814	Major facilitator Superfamily
HPC72_02700	COG0673	inositol 2-dehydrogenase activity
HPC72_02705	COG1609	Transcriptional regulator
HPC72_02715	COG0673	inositol 2-dehydrogenase activity
HPC72_02720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPC72_02725	COG2188	Transcriptional regulator
HPC72_02740	COG3718	enzyme involved in inositol metabolism
HPC72_02745	COG3962	Belongs to the TPP enzyme family
HPC72_02765	COG0673	inositol 2-dehydrogenase activity
HPC72_02770	COG1082	Xylose isomerase domain protein TIM barrel
HPC72_02775	COG2814	Major facilitator Superfamily
HPC72_02795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPC72_02795	COG0519	Catalyzes the synthesis of GMP from XMP
HPC72_02805	COG2197	response regulator
HPC72_02810	COG0667	Aldo Keto reductase
HPC72_02840	COG2197	response regulator
HPC72_02855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPC72_02865	COG0356	it plays a direct role in the translocation of protons across the membrane
HPC72_02870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPC72_02875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPC72_02880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPC72_02885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPC72_02890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPC72_02895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPC72_02925	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HPC72_02940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPC72_02955	COG0754	glutathionylspermidine amidase activity
HPC72_02965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPC72_02970	COG0254	rRNA binding
HPC72_02975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPC72_02980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPC72_02985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPC72_02995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPC72_03005	COG1254	Belongs to the acylphosphatase family
HPC72_03010	COG0708	Exodeoxyribonuclease III
HPC72_03020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPC72_03045	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPC72_03050	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPC72_03055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPC72_03065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPC72_03070	COG1611	Belongs to the LOG family
HPC72_03080	COG4122	O-methyltransferase activity
HPC72_03100	COG2239	Acts as a magnesium transporter
HPC72_03125	COG0006	proline dipeptidase activity
HPC72_03140	COG2095	MarC family integral membrane protein
HPC72_03145	COG0513	Belongs to the DEAD box helicase family
HPC72_03220	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPC72_03240	COG1132	(ABC) transporter
HPC72_03250	COG0039	L-malate dehydrogenase activity
HPC72_03265	COG1725	Transcriptional regulator
HPC72_03290	COG0058	SHG alpha-glucan phosphorylase activity
HPC72_03295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPC72_03300	COG3281	Trehalose synthase
HPC72_03310	COG0366	Alpha amylase catalytic
HPC72_03315	COG0180	Tryptophanyl-tRNA synthetase
HPC72_03330	COG2086	electron transfer activity
HPC72_03335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPC72_03340	COG0482	sulfurtransferase activity
HPC72_03350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPC72_03365	COG1468	defense response to virus
HPC72_03365	COG1518	maintenance of DNA repeat elements
HPC72_03405	COG1070	Carbohydrate kinase
HPC72_03410	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPC72_03425	COG1615	UPF0182 protein
HPC72_03560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPC72_03570	COG1192	Involved in chromosome partitioning
HPC72_03590	COG0114	fumarate hydratase activity
HPC72_03595	COG1125	glycine betaine transport
HPC72_03595	COG0517	IMP dehydrogenase activity
HPC72_03615	COG1609	Transcriptional regulator
HPC72_03620	COG0673	inositol 2-dehydrogenase activity
HPC72_03630	COG2814	Major facilitator Superfamily
HPC72_03640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPC72_03645	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPC72_03680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPC72_03690	COG4152	abc transporter atp-binding protein
HPC72_03700	COG1196	nuclear chromosome segregation
HPC72_03710	COG0789	Transcriptional regulator
HPC72_03720	COG2197	response regulator
HPC72_03725	COG4585	Histidine kinase
HPC72_03735	COG1131	(ABC) transporter
HPC72_03740	COG1115	amino acid carrier protein
HPC72_03745	COG0228	four-way junction DNA binding
HPC72_03750	COG1837	Belongs to the UPF0109 family
HPC72_03755	COG0667	Aldo Keto reductase
HPC72_03760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPC72_03765	COG0336	Belongs to the RNA methyltransferase TrmD family
HPC72_03770	COG0681	Belongs to the peptidase S26 family
HPC72_03780	COG0681	Belongs to the peptidase S26 family
HPC72_03785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPC72_03795	COG0792	nuclease activity
HPC72_03810	COG4974	Belongs to the 'phage' integrase family
HPC72_03820	COG0052	Belongs to the universal ribosomal protein uS2 family
HPC72_03825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPC72_03840	COG0528	UMP kinase activity
HPC72_03845	COG0233	cytoplasmic translational termination
HPC72_03850	COG0575	Belongs to the CDS family
HPC72_03855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPC72_03865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPC72_03870	COG0750	zinc metalloprotease
HPC72_03880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPC72_03890	COG0442	prolyl-tRNA aminoacylation
HPC72_03900	COG0779	Required for maturation of 30S ribosomal subunits
HPC72_03915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPC72_03950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPC72_03960	COG0477	Major facilitator Superfamily
HPC72_03965	COG1309	transcriptional regulator
HPC72_03985	COG1185	polyribonucleotide nucleotidyltransferase activity
HPC72_03990	COG0612	Peptidase, M16
HPC72_03995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPC72_04005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPC72_04015	COG0318	PFAM AMP-dependent synthetase and ligase
HPC72_04035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPC72_04045	COG2001	Belongs to the MraZ family
HPC72_04050	COG0275	rRNA processing
HPC72_04060	COG0768	penicillin binding
HPC72_04065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPC72_04070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPC72_04075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPC72_04080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPC72_04085	COG0772	Belongs to the SEDS family
HPC72_04090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPC72_04095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPC72_04105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPC72_04115	COG1799	cell septum assembly
HPC72_04125	COG3599	regulation of cell shape
HPC72_04130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPC72_04145	COG0587	DNA-directed DNA polymerase activity
HPC72_04150	COG2501	S4 domain
HPC72_04170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPC72_04185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPC72_04200	COG0514	ATP-dependent DNA helicase (RecQ)
HPC72_04210	COG0025	NhaP-type Na H and K H
HPC72_04215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPC72_04220	COG0131	Imidazoleglycerol-phosphate dehydratase
HPC72_04235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPC72_04240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPC72_04260	COG4868	Belongs to the UPF0371 family
HPC72_04265	COG0268	Binds directly to 16S ribosomal RNA
HPC72_04280	COG0159	tryptophan synthase activity
HPC72_04290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPC72_04300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPC72_04305	COG0133	tryptophan synthase activity
HPC72_04315	COG0481	GTPase activity
HPC72_04325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPC72_04330	COG2807	transmembrane transport
HPC72_04340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPC72_04355	COG1420	regulation of RNA biosynthetic process
HPC72_04360	COG0484	heat shock protein binding
HPC72_04370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPC72_04400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPC72_04410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPC72_04420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPC72_04425	COG1381	Involved in DNA repair and RecF pathway recombination
HPC72_04430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPC72_04435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HPC72_04440	COG0519	Catalyzes the synthesis of GMP from XMP
HPC72_04440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPC72_04450	COG0423	glycine-tRNA ligase activity
HPC72_04480	COG0560	Phosphoserine phosphatase
HPC72_04490	COG0297	glycogen (starch) synthase activity
HPC72_04505	COG1119	ATPase activity
HPC72_04530	COG0488	(ABC) transporter
HPC72_04575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HPC72_04585	COG0515	serine threonine protein kinase
HPC72_04585	COG2815	serine threonine protein kinase
HPC72_04595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPC72_04620	COG0187	DNA topoisomerase II activity
HPC72_04630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPC72_04675	COG0569	domain protein
HPC72_04680	COG0531	amino acid
HPC72_04685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPC72_04690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPC72_04695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPC72_04700	COG4221	oxidoreductase activity
HPC72_04705	COG1881	PFAM PEBP family protein
HPC72_04725	COG0833	amino acid
HPC72_04730	COG0587	DNA-directed DNA polymerase activity
HPC72_04740	COG0676	glucose-6-phosphate 1-epimerase activity
HPC72_04760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPC72_04770	COG0667	Aldo Keto reductase
HPC72_04780	COG2391	methyltransferase activity
HPC72_04795	COG1994	Peptidase M50
HPC72_04795	COG0517	IMP dehydrogenase activity
HPC72_04800	COG2814	Major facilitator Superfamily
HPC72_04810	COG1222	aaa ATPase
HPC72_04825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HPC72_04835	COG0107	imidazoleglycerol-phosphate synthase activity
HPC72_04855	COG1297	OPT oligopeptide transporter protein
HPC72_04860	COG0134	indole-3-glycerol-phosphate synthase activity
HPC72_04865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPC72_04895	COG0539	negative regulation of cytoplasmic translation
HPC72_04905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPC72_04905	COG0237	dephospho-CoA kinase activity
HPC72_04910	COG0556	nucleotide-excision repair
HPC72_04940	COG2226	methyltransferase
HPC72_04955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPC72_04960	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HPC72_04965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPC72_04995	COG0322	excinuclease ABC activity
HPC72_05000	COG1263	PTS System
HPC72_05000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPC72_05000	COG2190	(PTS) system
HPC72_05010	COG3711	transcriptional antiterminator
HPC72_05015	COG1660	Displays ATPase and GTPase activities
HPC72_05025	COG1481	regulation of sporulation
HPC72_05030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPC72_05035	COG0126	phosphoglycerate kinase activity
HPC72_05040	COG0149	triose-phosphate isomerase activity
HPC72_05045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPC72_05060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPC72_05065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPC72_05080	COG1160	GTP binding
HPC72_05090	COG0166	Belongs to the GPI family
HPC72_05115	COG5290	Psort location Cytoplasmic, score
HPC72_05125	COG1309	transcriptional regulator
HPC72_05170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPC72_05175	COG1716	ATPase activity
HPC72_05195	COG0443	Heat shock 70 kDa protein
HPC72_05200	COG1263	PTS System
HPC72_05200	COG2190	(PTS) system
HPC72_05200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPC72_05205	COG1609	Transcriptional regulator
HPC72_05230	COG1216	Glycosyl transferase, family 2
HPC72_05245	COG0805	protein transport
HPC72_05250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPC72_05270	COG0140	phosphoribosyl-ATP diphosphatase activity
HPC72_05275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPC72_05280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPC72_05285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPC72_05295	COG1335	isochorismatase
HPC72_05305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPC72_05310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPC72_05315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPC72_05320	COG4770	biotin carboxylase activity
HPC72_05330	COG1131	(ABC) transporter
HPC72_05335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPC72_05345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPC72_05365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPC72_05375	COG1758	RNA polymerase activity
HPC72_05385	COG0194	GDP metabolic process
HPC72_05395	COG0284	orotidine-5'-phosphate decarboxylase activity
HPC72_05400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPC72_05410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPC72_05415	COG0540	Belongs to the ATCase OTCase family
HPC72_05420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HPC72_05430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPC72_05435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPC72_05445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPC72_05455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPC72_05460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPC72_05470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPC72_05480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPC72_05485	COG0730	response to heat
HPC72_05495	COG2409	Drug exporters of the RND superfamily
HPC72_05500	COG0009	L-threonylcarbamoyladenylate synthase
HPC72_05505	COG0640	Transcriptional regulator
HPC72_05515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPC72_05545	COG0124	histidyl-tRNA synthetase
HPC72_05565	COG1196	nuclear chromosome segregation
HPC72_05575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPC72_05580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPC72_05585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPC72_05590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPC72_05600	COG2255	four-way junction helicase activity
HPC72_05605	COG0632	four-way junction helicase activity
HPC72_05610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPC72_05615	COG0217	transcriptional regulatory protein
HPC72_05620	COG0494	nUDIX hydrolase
HPC72_05635	COG0438	transferase activity, transferring glycosyl groups
HPC72_05640	COG1560	Kdo2-lipid A biosynthetic process
HPC72_05645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPC72_05655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPC72_05665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPC72_05715	COG1882	Formate acetyltransferase
HPC72_05730	COG0038	chloride channel
HPC72_05740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPC72_05745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPC72_05750	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPC72_05760	COG0321	lipoyl(octanoyl) transferase activity
HPC72_05765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPC72_05785	COG0765	amino acid transport
HPC72_05800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPC72_05805	COG0174	glutamine synthetase
HPC72_05810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPC72_05835	COG3022	response to hydroperoxide
HPC72_05845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPC72_05885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPC72_05890	COG1027	Aspartate ammonia-lyase
HPC72_05900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPC72_05960	COG0358	DNA primase activity
HPC72_05980	COG1929	Belongs to the glycerate kinase type-1 family
HPC72_05985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPC72_05995	COG0667	Aldo Keto reductase
HPC72_06000	COG0167	dihydroorotate dehydrogenase activity
HPC72_06015	COG4589	Belongs to the CDS family
HPC72_06030	COG1131	(ABC) transporter
HPC72_06040	COG2151	metal-sulfur cluster biosynthetic enzyme
HPC72_06045	COG0822	iron-sulfur transferase activity
HPC72_06055	COG0396	ATPase activity
HPC72_06065	COG0719	Fe-S assembly protein
HPC72_06080	COG0483	inositol monophosphate 1-phosphatase activity
HPC72_06110	COG0497	DNA recombination
HPC72_06115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPC72_06130	COG0647	UMP catabolic process
HPC72_06160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPC72_06165	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HPC72_06180	COG2094	Belongs to the DNA glycosylase MPG family
HPC72_06185	COG0165	Argininosuccinate lyase
HPC72_06195	COG0137	argininosuccinate synthase activity
HPC72_06200	COG1438	arginine binding
HPC72_06205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPC72_06210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPC72_06220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPC72_06230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPC72_06230	COG0072	phenylalanine-tRNA ligase activity
HPC72_06245	COG0765	amino acid transport
HPC72_06250	COG0765	amino acid transport
HPC72_06255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPC72_06260	COG1126	abc transporter atp-binding protein
HPC72_06265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPC72_06270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPC72_06275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPC72_06280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPC72_06295	COG0658	competence protein
HPC72_06295	COG2333	competence protein COMEC
HPC72_06305	COG1307	EDD domain protein, DegV family
HPC72_06310	COG0433	COG0433 Predicted ATPase
HPC72_06315	COG0495	leucyl-tRNA aminoacylation
HPC72_06320	COG0537	adenosine 5'-monophosphoramidase activity
HPC72_06350	COG0733	neurotransmitter:sodium symporter activity
HPC72_06375	COG0406	alpha-ribazole phosphatase activity
HPC72_06380	COG0799	negative regulation of ribosome biogenesis
HPC72_06390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPC72_06395	COG1349	DNA-binding transcription factor activity
HPC72_06400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPC72_06410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPC72_06415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPC72_06420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPC72_06425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPC72_06430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPC72_06435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPC72_06445	COG0785	Cytochrome C biogenesis protein
HPC72_06460	COG3005	denitrification pathway
HPC72_06465	COG1530	ribonuclease E activity
HPC72_06470	COG1271	oxidase subunit
HPC72_06475	COG1294	oxidase, subunit
HPC72_06480	COG4988	ABC transporter
HPC72_06485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPC72_06500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPC72_06505	COG0571	ribonuclease III activity
HPC72_06520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPC72_06535	COG1461	Dihydroxyacetone kinase
HPC72_06540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPC72_06550	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPC72_06565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPC72_06575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPC72_06580	COG0066	3-isopropylmalate dehydratase activity
HPC72_06585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPC72_06600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPC72_06610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPC72_06625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPC72_06635	COG2813	Specifically methylates the guanine in position
HPC72_06645	COG1114	Component of the transport system for branched-chain amino acids
HPC72_06650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPC72_06655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPC72_06680	COG0577	efflux transmembrane transporter activity
HPC72_06680	COG1136	(ABC) transporter
HPC72_06700	COG0672	)-iron permease
HPC72_06710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPC72_06715	COG1846	Transcriptional regulator
HPC72_06715	COG1940	carbohydrate kinase activity
HPC72_06725	COG1175	transmembrane transport
HPC72_06730	COG0395	ABC-type sugar transport system, permease component
HPC72_06740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPC72_06745	COG2137	regulation of response to DNA damage stimulus
HPC72_06750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPC72_06760	COG1396	sequence-specific DNA binding
HPC72_06765	COG1546	Belongs to the CinA family
HPC72_06765	COG1058	Belongs to the CinA family
HPC72_06775	COG1674	ftsk spoiiie
HPC72_06785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPC72_06820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPC72_06830	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPC72_06835	COG1115	amino acid carrier protein
HPC72_06840	COG1115	amino acid carrier protein
HPC72_06845	COG1115	amino acid carrier protein
HPC72_06850	COG1115	amino acid carrier protein
HPC72_06860	COG2040	homocysteine
HPC72_06865	COG0833	amino acid
HPC72_06870	COG3304	Inner membrane component domain
HPC72_06910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPC72_06915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPC72_06930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPC72_06940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPC72_06960	COG0363	glucosamine-6-phosphate deaminase activity
HPC72_06970	COG1131	(ABC) transporter
HPC72_06980	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HPC72_06985	COG1940	carbohydrate kinase activity
HPC72_06990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPC72_06995	COG4608	Belongs to the ABC transporter superfamily
HPC72_07000	COG0444	Belongs to the ABC transporter superfamily
HPC72_07010	COG4166	transmembrane transport
HPC72_07015	COG2188	Transcriptional regulator
HPC72_07020	COG2233	PERMEase
HPC72_07040	COG2177	Part of the ABC transporter FtsEX involved in
HPC72_07045	COG2884	Cell division ATP-binding protein ftsE
HPC72_07055	COG0629	single-stranded DNA binding
HPC72_07075	COG1131	(ABC) transporter
HPC72_07075	COG1716	ATPase activity
HPC72_07075	COG0842	Transport permease protein
HPC72_07080	COG0515	serine threonine protein kinase
HPC72_07085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPC72_07095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPC72_07100	COG1086	Polysaccharide biosynthesis protein
HPC72_07105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPC72_07150	COG1216	Glycosyl transferase, family 2
HPC72_07155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPC72_07160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPC72_07165	COG1316	TRANSCRIPTIONal
HPC72_07175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPC72_07180	COG0473	3-isopropylmalate dehydrogenase activity
HPC72_07185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPC72_07200	COG0569	domain protein
HPC72_07200	COG2985	domain, Protein
HPC72_07205	COG2966	Psort location CytoplasmicMembrane, score
HPC72_07210	COG1609	Transcriptional regulator
HPC72_07215	COG5492	domain, Protein
HPC72_07215	COG1621	beta-fructofuranosidase activity
HPC72_07215	COG3583	domain protein
HPC72_07220	COG0395	ABC-type sugar transport system, permease component
HPC72_07225	COG1175	transmembrane transport
HPC72_07255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPC72_07260	COG0154	amidase activity
HPC72_07265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPC72_07275	COG0105	UTP biosynthetic process
HPC72_07280	COG0285	dihydrofolate synthase activity
HPC72_07285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPC72_07295	COG0489	protein tyrosine kinase activity
HPC72_07305	COG0110	maltose O-acetyltransferase activity
HPC72_07315	COG0438	transferase activity, transferring glycosyl groups
HPC72_07325	COG1215	transferase activity, transferring glycosyl groups
HPC72_07330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPC72_07335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPC72_07340	COG0175	sulfate reduction
HPC72_07355	COG1648	precorrin-2 dehydrogenase activity
HPC72_07355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPC72_07360	COG0730	response to heat
HPC72_07375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPC72_07380	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HPC72_07395	COG1222	aaa ATPase
HPC72_07405	COG1022	Amp-dependent synthetase and ligase
HPC72_07415	COG0287	Prephenate dehydrogenase
HPC72_07415	COG1605	Chorismate mutase
HPC72_07420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPC72_07425	COG0740	serine-type endopeptidase activity
HPC72_07460	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPC72_07515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPC72_07565	COG0778	Nitroreductase
HPC72_07590	COG1739	Uncharacterized protein family UPF0029
HPC72_07600	COG1045	serine acetyltransferase
HPC72_07610	COG1929	Belongs to the glycerate kinase type-1 family
HPC72_07615	COG0698	ribose 5-phosphate isomerase
HPC72_07620	COG3590	peptidase
HPC72_07640	COG2188	Transcriptional regulator
HPC72_07645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPC72_07660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPC72_07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPC72_07670	COG1946	Acyl-CoA thioesterase
HPC72_07695	COG0205	6-phosphofructokinase activity
HPC72_07710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPC72_07715	COG0366	Alpha amylase catalytic
HPC72_07725	COG1175	transmembrane transport
HPC72_07735	COG1940	carbohydrate kinase activity
HPC72_07735	COG1846	Transcriptional regulator
HPC72_07800	COG1120	ATPase activity
HPC72_07815	COG2188	Transcriptional regulator
HPC72_07840	COG1131	(ABC) transporter
HPC72_07845	COG2890	protein-(glutamine-N5) methyltransferase activity
HPC72_07850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPC72_07855	COG0254	rRNA binding
HPC72_07875	COG0701	Predicted permease
HPC72_07885	COG0083	homoserine kinase activity
HPC72_07890	COG0460	homoserine dehydrogenase
HPC72_07895	COG0019	diaminopimelate decarboxylase activity
HPC72_07900	COG0018	arginyl-trna synthetase
HPC72_07920	COG0584	glycerophosphoryl diester phosphodiesterase
HPC72_07935	COG1253	flavin adenine dinucleotide binding
HPC72_07940	COG0567	Dehydrogenase, E1 component
HPC72_07940	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPC72_07960	COG5662	AntiSigma factor
HPC72_07965	COG1595	DNA-templated transcription, initiation
HPC72_07970	COG1695	Transcriptional regulator
HPC72_07985	COG2838	Isocitrate dehydrogenase
HPC72_07990	COG0222	ribosome binding
HPC72_07995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPC72_08000	COG0081	regulation of translation
HPC72_08005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPC72_08010	COG0250	Participates in transcription elongation, termination and antitermination
HPC72_08030	COG1937	Protein conserved in bacteria
HPC72_08035	COG0436	Aminotransferase
HPC72_08045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPC72_08050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPC72_08065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPC72_08075	COG2017	converts alpha-aldose to the beta-anomer
HPC72_08080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPC72_08080	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HPC72_08080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPC72_08090	COG2376	Dihydroxyacetone kinase
HPC72_08100	COG2814	Major facilitator Superfamily
HPC72_08115	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPC72_08150	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPC72_08155	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HPC72_08170	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPC72_08190	COG1070	Carbohydrate kinase
HPC72_08195	COG0647	UMP catabolic process
HPC72_08205	COG0698	ribose 5-phosphate isomerase
HPC72_08220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPC72_08225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPC72_08230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPC72_08240	COG2217	Heavy metal translocating P-type atpase
HPC72_08245	COG1620	l-lactate permease
HPC72_08250	COG0247	lactate metabolic process
HPC72_08255	COG1139	Iron-sulfur cluster binding protein
HPC72_08260	COG1556	Lactate utilization protein
HPC72_08285	COG3104	oligopeptide transport
HPC72_08290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPC72_08320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPC72_08335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPC72_08350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPC72_08375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPC72_08380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPC72_08385	COG0302	gtp cyclohydrolase
HPC72_08390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPC72_08440	COG2027	D-alanyl-D-alanine carboxypeptidase
HPC72_08445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPC72_08450	COG0791	NLP P60 protein
HPC72_08455	COG2873	o-acetylhomoserine
HPC72_08460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPC72_08485	COG0406	alpha-ribazole phosphatase activity
HPC72_08525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPC72_08530	COG1268	BioY protein
HPC72_08550	COG1902	pentaerythritol trinitrate reductase activity
HPC72_08555	COG3012	SEC-C Motif Domain Protein
HPC72_08560	COG1362	aminopeptidase activity
HPC72_08625	COG3422	double-strand break repair
HPC72_08635	COG1131	(ABC) transporter
HPC72_08645	COG1136	(ABC) transporter
HPC72_08650	COG0577	efflux transmembrane transporter activity
HPC72_08660	COG0012	GTP binding
HPC72_08670	COG1322	Protein conserved in bacteria
HPC72_08675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPC72_08680	COG1570	exodeoxyribonuclease VII activity
HPC72_08685	COG1722	exodeoxyribonuclease VII activity
HPC72_08695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPC72_08705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPC72_08710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPC72_08725	COG0431	NADPH-dependent FMN reductase
HPC72_08730	COG0431	NADPH-dependent FMN reductase
HPC72_08740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPC72_08745	COG0129	dihydroxy-acid dehydratase activity
HPC72_08750	COG0545	Peptidyl-prolyl cis-trans isomerase
HPC72_08760	COG1131	(ABC) transporter
HPC72_08775	COG2197	response regulator
HPC72_08780	COG0193	aminoacyl-tRNA hydrolase activity
HPC72_08785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPC72_08790	COG0710	3-dehydroquinate dehydratase activity
HPC72_08810	COG0148	phosphopyruvate hydratase activity
HPC72_08845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPC72_08900	COG0297	glycogen (starch) synthase activity
HPC72_08920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPC72_08920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPC72_08960	COG0515	serine threonine protein kinase
HPC72_08970	COG0488	(ABC) transporter
HPC72_08975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPC72_08980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPC72_08985	COG1388	LysM domain
HPC72_09000	COG0084	hydrolase, TatD family'
HPC72_09005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPC72_09055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPC72_09065	COG1970	mechanosensitive ion channel activity
HPC72_09100	COG1388	LysM domain
HPC72_09100	COG3103	Sh3 type 3 domain protein
HPC72_09100	COG0791	NLP P60 protein
HPC72_09115	COG2252	PERMEase
HPC72_09145	COG1061	Type III restriction enzyme res subunit
HPC72_09160	COG1842	Phage shock protein A
HPC72_09170	COG0745	RESPONSE REGULATOR receiver
HPC72_09175	COG2205	protein histidine kinase activity
HPC72_09190	COG0459	protein refolding
HPC72_09205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPC72_09215	COG2890	protein-(glutamine-N5) methyltransferase activity
HPC72_09220	COG1940	carbohydrate kinase activity
HPC72_09220	COG1846	Transcriptional regulator
HPC72_09225	COG2115	Belongs to the xylose isomerase family
HPC72_09230	COG1070	Carbohydrate kinase
HPC72_09245	COG4214	carbohydrate transport
HPC72_09265	COG3842	ATPase activity
HPC72_09285	COG0215	cysteine-tRNA ligase activity
HPC72_09290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPC72_09330	COG3716	PTS system mannose fructose sorbose family IID component
HPC72_09335	COG3715	PTS system
HPC72_09340	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPC72_09340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPC72_09355	COG1609	Transcriptional regulator
HPC72_09360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPC72_09415	COG0745	RESPONSE REGULATOR receiver
HPC72_09420	COG2205	protein histidine kinase activity
HPC72_09425	COG0789	Transcriptional regulator
HPC72_09430	COG0484	heat shock protein binding
HPC72_09435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPC72_09440	COG0443	Heat shock 70 kDa protein
HPC72_09455	COG2233	PERMEase
HPC72_09480	COG1643	Atp-dependent helicase
HPC72_09495	COG0110	maltose O-acetyltransferase activity
HPC72_09505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPC72_09510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPC72_09515	COG1464	Belongs to the NlpA lipoprotein family
HPC72_09520	COG2011	ABC-type metal ion transport system permease component
HPC72_09535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPC72_09550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPC72_09560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPC72_09575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPC72_09585	COG1609	Transcriptional regulator
HPC72_09610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPC72_09615	COG1780	Probably involved in ribonucleotide reductase function
HPC72_09635	COG3550	peptidyl-serine autophosphorylation
HPC72_09665	COG1196	nuclear chromosome segregation
HPC72_09680	COG0628	permease
HPC72_09685	COG0596	Alpha beta hydrolase
HPC72_09690	COG1854	S-ribosylhomocysteine lyase activity
HPC72_09700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPC72_09720	COG2985	domain, Protein
HPC72_09720	COG0569	domain protein
HPC72_09745	COG1113	amino acid transport
HPC72_09755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPC72_09760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPC72_09770	COG1940	carbohydrate kinase activity
HPC72_09780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPC72_09785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPC72_09790	COG1120	ATPase activity
HPC72_09800	COG0305	Participates in initiation and elongation during chromosome replication
HPC72_09810	COG0359	binds to the 23S rRNA
HPC72_09815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPC72_09820	COG0629	single-stranded DNA binding
HPC72_09825	COG0360	Binds together with S18 to 16S ribosomal RNA
HPC72_09830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPC72_09850	COG1953	Uracil, thiamine, allantoin
HPC72_09855	COG3960	tartronate-semialdehyde synthase activity
HPC72_09865	COG3958	Transketolase
HPC72_09870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPC72_09880	COG0540	Belongs to the ATCase OTCase family
HPC72_09885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPC72_09890	COG1953	Uracil, thiamine, allantoin
HPC72_09920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPC72_09930	COG0617	tRNA 3'-terminal CCA addition
HPC72_09955	COG3118	belongs to the thioredoxin family
HPC72_09965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPC72_09970	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPC72_09985	COG0357	Ribosomal RNA small subunit methyltransferase G
HPC72_09995	COG0706	membrane insertase activity
HPC72_10000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPC72_10005	COG0594	ribonuclease P activity
HPC72_10010	COG0230	Belongs to the bacterial ribosomal protein bL34 family