locus-tag class description AFR_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AFR_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AFR_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase AFR_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AFR_00025 ENOG4105K7N UPF0232 protein AFR_00040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFR_00045 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFR_00070 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AFR_00090 ENOG4105XYF acetyltransferase AFR_00095 ENOG4107ZXU DSBA oxidoreductase AFR_00110 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AFR_00135 ENOG4105CIG ABC transporter AFR_00155 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AFR_00170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AFR_00175 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AFR_00190 ENOG4107QX3 carboxylase AFR_00195 ENOG4105C1G acyl-Coa dehydrogenase AFR_00205 ENOG41090MY MarR family Transcriptional regulator AFR_00210 ENOG4108YYC ycei family AFR_00255 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AFR_00260 ENOG4108IAJ Nad-dependent epimerase dehydratase AFR_00265 ENOG4105TV9 FHA Domain-Containing protein AFR_00265 ENOG4105TV9 FHA Domain-Containing protein AFR_00270 ENOG4105HZM Fha domain containing protein AFR_00285 ENOG4105CJN penicillin-binding protein AFR_00290 ENOG4107TPY serine threonine protein kinase AFR_00295 ENOG4105D9P serine threonine protein kinase AFR_00320 ENOG4105ZJT Cell division protein CrgA AFR_00325 ENOG4105DF6 Fe-S oxidoreductase AFR_00365 ENOG41062IR nudix hydrolase AFR_00385 ENOG4105DHP deoxycytidine triphosphate deaminase AFR_00415 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AFR_00430 ENOG4105CSU acyl-Coa dehydrogenase AFR_00445 ENOG4105ECR NmrA family AFR_00480 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AFR_00485 ENOG4105CPP Dehydrogenase, E1 component AFR_00520 ENOG4105CFG Acts as a chaperone (By similarity) AFR_00525 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AFR_00530 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AFR_00535 ENOG4105KNI merR family transcriptional Regulator AFR_00545 ENOG4105CKD glutathione-regulated potassium-efflux system protein AFR_00555 ENOG4105S8Q sugar efflux transporter AFR_00565 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AFR_00590 ENOG4107YCR Transcriptional regulator, ARSR family AFR_00600 ENOG4105DQR SNARE associated Golgi AFR_00605 ENOG4107S1Q Phosphatase AFR_00615 ENOG4105NAF rna polymerase sigma factor AFR_00680 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AFR_00685 ENOG4105C12 Phosphoribosylglycinamide synthetase AFR_00705 ENOG4105C83 adenylosuccinate lyase AFR_00715 ENOG410839H phosphoribosylformylglycinamidine synthase AFR_00720 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AFR_00725 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii AFR_00745 ENOG4105CXB phosphoribosylaminoimidazole synthetase AFR_00770 ENOG4108TAC AFR_00810 ENOG4105KA0 thioesterase Superfamily protein AFR_00835 ENOG41082AN stage II sporulation protein AFR_00850 ENOG4105CHP RNA polymerase AFR_00855 ENOG4105GRZ Ycii-related protein AFR_00880 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AFR_00900 ENOG4105CVP deoxyribo-dipyrimidine photolyase AFR_00915 ENOG4107QN2 dihydrolipoyl dehydrogenase AFR_00940 ENOG4105CQB FAD linked oxidase domain protein AFR_00960 ENOG4108MJN Glycosyl Transferase AFR_00975 ENOG4107S2Z UPF0761 membrane protein AFR_01030 ENOG4105U5Y Transcriptional regulator AFR_01035 ENOG4105CHP RNA polymerase AFR_01045 ENOG4105VMP Transcriptional regulator AFR_01070 ENOG4108KSA LysR family transcriptional regulator AFR_01080 ENOG4105CPC Aldo Keto reductase AFR_01100 ENOG41062D9 Histidine kinase AFR_01105 ENOG4105ETX regulatoR AFR_01120 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_01125 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_01135 ENOG4105C8Q Methyl-accepting chemotaxis AFR_01170 ENOG4105M4P Tetr family transcriptional regulator AFR_01200 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AFR_01210 ENOG4107MMM Anti-sigma-factor antagonist AFR_01215 ENOG4105FUA antagonist AFR_01220 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase AFR_01230 ENOG4105BZU Histidine kinase AFR_01235 ENOG4108KXV response regulator AFR_01245 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_01265 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AFR_01270 ENOG4105NAE bifunctional deaminase-reductase domain protein AFR_01275 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_01280 ENOG4105JNK Glycosyl transferase (Group 1 AFR_01285 ENOG4105CKK Glycosyl transferase, family 2 AFR_01295 ENOG4105BZU Histidine kinase AFR_01300 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AFR_01315 ENOG4105WN5 stage II sporulation protein AFR_01320 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AFR_01325 ENOG4108RH7 phosphoglycerate mutase AFR_01330 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AFR_01335 ENOG4107QIV Cytochrome c biogenesis protein AFR_01345 ENOG4105CRE cytochrome C AFR_01350 ENOG4105BZ1 (ABC) transporter AFR_01355 ENOG4105BZ1 (ABC) transporter AFR_01370 ENOG4108IJG ABC transporter substrate-binding protein AFR_01380 ENOG4105CG3 alpha amylase, catalytic region AFR_01400 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AFR_01410 ENOG4105EMN RNA polymerase sigma factor AFR_01420 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AFR_01430 ENOG4108VVK transcriptional Regulator, AsnC AFR_01450 ENOG4105C1J atp-dependent rna helicase AFR_01465 ENOG4105ZXU NLP P60 protein AFR_01470 ENOG4105DVY radical SAM domain protein AFR_01520 ENOG4105EHG Permease protein AFR_01525 ENOG4105E0A ABC, transporter AFR_01540 ENOG4108M15 ABC transporter AFR_01560 ENOG4105EEM helicase AFR_01570 ENOG4107Y80 Major Facilitator superfamily AFR_01575 ENOG4105EV6 Pfam:DUF178 AFR_01585 ENOG4105C3Q Glycosyl transferase, family 2 AFR_01600 ENOG4105CPC Aldo Keto reductase AFR_01610 ENOG4107XWB Zinc finger, swim domain protein AFR_01615 ENOG4105C0D helicase AFR_01630 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AFR_01660 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_01665 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AFR_01670 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_01685 ENOG4108IEH NADH dehydrogenase subunit g AFR_01690 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AFR_01695 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_01700 ENOG4105DF2 NADH dehydrogenase subunit j AFR_01705 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_01720 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_01760 ENOG41082T9 Membrane AFR_01790 ENOG4105D74 hydrolase AFR_01800 ENOG4107G87 m6 family metalloprotease domain protein AFR_01810 ENOG4107G87 m6 family metalloprotease domain protein AFR_01815 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AFR_01875 ENOG4108I5C dEAD DEAH box helicase AFR_01880 ENOG4105WN5 stage II sporulation protein AFR_01890 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for AFR_01905 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AFR_01915 ENOG4108SGK Tetr family transcriptional regulator AFR_01925 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AFR_01930 ENOG4105C6E dna polymerase iii AFR_01955 ENOG4105MA4 psp1 domain protein AFR_01985 ENOG4106UW1 Major Facilitator superfamily AFR_01990 ENOG4108RFG Tetr family transcriptional regulator AFR_02000 ENOG4105D0A hydroxylase AFR_02045 ENOG4107RKG DJ-1/PfpI family AFR_02050 ENOG41062IR nudix hydrolase AFR_02055 ENOG4105FDF Could be involved in DNA repair (By similarity) AFR_02060 ENOG4105DQE DNA ligase AFR_02065 ENOG4105DQE DNA ligase AFR_02080 ENOG4105CFI type iii restriction protein res subunit AFR_02095 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AFR_02100 ENOG4105VEQ Cold shock protein AFR_02105 ENOG4105E63 Pfam:DUF178 AFR_02110 ENOG4108UIH futalosine nucleosidase AFR_02115 ENOG4108N0W Major Facilitator superfamily AFR_02130 ENOG4105C7N Xanthine uracil vitamin C permease AFR_02135 ENOG4105K56 Transcriptional regulator AFR_02140 ENOG4107SFI Major Facilitator superfamily AFR_02145 ENOG4105C7B Threonine dehydratase AFR_02150 ENOG4107YCY Transcriptional regulator AFR_02155 ENOG4105DJ2 Major Facilitator Superfamily AFR_02190 ENOG4105CIH Imidazole acetol-phosphate transaminase AFR_02195 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AFR_02205 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AFR_02215 ENOG4107WI4 Aldose-1-epimerase AFR_02230 ENOG4105C1G acyl-Coa dehydrogenase AFR_02255 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFR_02285 ENOG4105EY8 ABC transporter AFR_02295 ENOG4108JGH Tetr family transcriptional regulator AFR_02300 ENOG4105BZU Histidine kinase AFR_02330 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AFR_02340 ENOG4105BZU Histidine kinase AFR_02400 ENOG4108I69 Glycosyl transferases group 1 AFR_02420 ENOG4105NAF rna polymerase sigma factor AFR_02435 ENOG4105CNN ABC, transporter AFR_02440 ENOG4107R9N ABC transporter AFR_02445 ENOG4105C2J ABC transporter AFR_02455 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AFR_02545 ENOG4105EC2 ftsk spoIIIe AFR_02565 ENOG4106F1P AAA ATPase, central domain protein AFR_02570 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AFR_02590 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_02630 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AFR_02635 ENOG4105ETX regulatoR AFR_02670 ENOG4107TY6 Acylneuraminate cytidylyltransferase AFR_02685 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AFR_02690 ENOG4105C5E polysaccharide biosynthesis protein AFR_02700 ENOG4105CHR reductase AFR_02705 ENOG4105CEY Amp-dependent synthetase and ligase AFR_02720 ENOG4105CKK Glycosyl transferase, family 2 AFR_02745 ENOG4105EE1 crotonyl-CoA reductase AFR_02770 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_02785 ENOG41067RQ csbd family AFR_02790 ENOG4105BZU Histidine kinase AFR_02795 ENOG4107QRS glycosyltransferase group 2 family protein AFR_02805 ENOG4105D2T synthase AFR_02830 ENOG41083YR Protein CrcB homolog AFR_02835 ENOG41083TI Protein CrcB homolog AFR_02855 ENOG4105BZU Histidine kinase AFR_02880 ENOG4105CPQ Dehydrogenase AFR_02900 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFR_02920 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AFR_02965 ENOG4105CTS PTS system mannitol-specific AFR_02975 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AFR_02985 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AFR_02995 ENOG4107SJS nitrite reductase, (NAD(P)H) AFR_03065 ENOG4105EZR dyp-type peroxidase family protein AFR_03080 ENOG4105CWX Alpha-1,2-mannosidase AFR_03085 ENOG4105DQE DNA ligase AFR_03125 ENOG4105DTD Dehydrogenase AFR_03135 ENOG4105CPC Aldo Keto reductase AFR_03170 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFR_03180 ENOG4105DKT Transcriptional regulator AFR_03185 ENOG4105CHR reductase AFR_03190 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AFR_03205 ENOG4105EGE secreted protein AFR_03210 ENOG41060NJ transcriptional regulator AFR_03215 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator AFR_03220 ENOG4105CNN ABC, transporter AFR_03225 ENOG4105C2J ABC transporter AFR_03245 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AFR_03255 ENOG4105CNN ABC, transporter AFR_03265 ENOG4105C2J ABC transporter AFR_03280 ENOG4105DET Rhamnulokinase AFR_03285 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AFR_03290 ENOG4107QR9 Iron-sulfur cluster binding protein AFR_03295 ENOG41080R8 Conserved Protein AFR_03315 ENOG4108X07 Tetr family transcriptional regulator AFR_03320 ENOG4105CIG ABC transporter AFR_03325 ENOG4105DIM ABC transporter AFR_03335 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AFR_03350 ENOG4105GRZ Ycii-related protein AFR_03355 ENOG4105CHP RNA polymerase AFR_03365 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AFR_03375 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AFR_03380 ENOG4105D0M Protease HtpX homolog AFR_03385 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AFR_03395 ENOG4106A3M Cytochrome p-450 AFR_03415 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AFR_03435 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_03455 ENOG4105C8Q Methyl-accepting chemotaxis AFR_03465 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AFR_03470 ENOG4107RTD sua5 ycio yrdc ywlc family protein AFR_03490 ENOG4105BZU Histidine kinase AFR_03520 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_03525 ENOG4105CIS alcohol dehydrogenase AFR_03570 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AFR_03635 ENOG4105CSA Coproporphyrinogen iii oxidase AFR_03645 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AFR_03660 ENOG4107RRE RNA-directed DNA polymerase AFR_03725 ENOG4108IG5 Transcriptional regulator AFR_03740 ENOG4107S9F NmrA family AFR_03745 ENOG4105BZ1 (ABC) transporter AFR_03760 ENOG4105KME endoribonuclease L-psp AFR_03800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFR_03875 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AFR_03880 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AFR_03885 ENOG4107HP6 Transcriptional regulator AFR_03925 ENOG4105EDW glycosyl transferase, family 39 AFR_03930 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AFR_03940 ENOG4105BZU Histidine kinase AFR_03945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_03970 ENOG4105C98 muts2 protein AFR_03985 ENOG4105EEX Two component transcriptional regulator (Winged helix family AFR_03990 ENOG4105BZU Histidine kinase AFR_04000 ENOG4108MWI inositol mono-phosphatase AFR_04010 ENOG4108R85 Short chain dehydrogenase AFR_04025 ENOG4105D9P serine threonine protein kinase AFR_04030 ENOG4107ZYR domain protein AFR_04035 ENOG4105CZN Potassium uptake protein AFR_04065 ENOG4105C9U ATP-dependent DNA helicase RecQ AFR_04070 ENOG4105K4H Nlp p60 protein AFR_04075 ENOG4105VPX protein, conserved in bacteria AFR_04105 ENOG4105C1J atp-dependent rna helicase AFR_04125 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AFR_04155 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AFR_04160 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AFR_04170 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) AFR_04200 ENOG4108N5B 2-phosphosulfolactate phosphatase AFR_04205 ENOG4105CVK Glutamate decarboxylase AFR_04210 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_04225 ENOG4105DU6 RNA polymerase AFR_04230 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_04235 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AFR_04250 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_04260 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_04265 ENOG4105D65 subunit l AFR_04270 ENOG4105C8S subunit m AFR_04280 ENOG4105D0M Protease HtpX homolog AFR_04295 ENOG4105FDP GntR family transcriptional regulator AFR_04315 ENOG4105DEN Luciferase family AFR_04340 ENOG4105CHP RNA polymerase AFR_04380 ENOG4108VPT UPF0234 protein AFR_04390 ENOG4105KHC sulfurtransferase AFR_04400 ENOG4105BZU Histidine kinase AFR_04405 ENOG4105WDJ 50S ribosomal protein L33 AFR_04410 ENOG410900P UPF0336 protein AFR_04430 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AFR_04445 ENOG4108VZM 50s ribosomal protein L10 AFR_04460 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AFR_04465 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AFR_04480 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AFR_04485 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AFR_04490 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AFR_04495 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AFR_04500 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AFR_04505 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AFR_04510 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AFR_04515 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AFR_04520 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AFR_04525 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AFR_04530 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AFR_04535 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AFR_04540 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AFR_04545 ENOG41082SA 50s ribosomal protein l29 AFR_04550 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AFR_04555 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AFR_04560 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AFR_04565 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AFR_04570 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AFR_04575 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AFR_04580 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AFR_04585 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AFR_04590 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AFR_04595 ENOG410849U 50S ribosomal protein L30 AFR_04600 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AFR_04605 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AFR_04610 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AFR_04630 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AFR_04635 ENOG41067V7 50S ribosomal protein L36 AFR_04640 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AFR_04645 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AFR_04650 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AFR_04660 ENOG4108ZT0 50S ribosomal protein l17 AFR_04665 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AFR_04675 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AFR_04680 ENOG4105C5H ABC transporter AFR_04695 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AFR_04705 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AFR_04710 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AFR_04720 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AFR_04745 ENOG4107XKF NMT1 THI5 Like Domain Protein AFR_04750 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component AFR_04765 ENOG4105GWZ Roadblock lc7 family protein AFR_04785 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AFR_04790 ENOG4108UJD 30S ribosomal protein S9 AFR_04795 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AFR_04810 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AFR_04825 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AFR_04835 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AFR_04845 ENOG4108097 ATP-binding protein AFR_04850 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AFR_04865 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AFR_04875 ENOG4105BZ1 (ABC) transporter AFR_04880 ENOG4105BZ1 (ABC) transporter AFR_04890 ENOG4107RNG ABC transporter AFR_04895 ENOG4105C2J ABC transporter AFR_04905 ENOG4108Z66 YbaK ebsC protein AFR_04915 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AFR_04920 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AFR_04935 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AFR_04940 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_04945 ENOG4108VT4 AFR_04955 ENOG4107QVP Dehydrogenase AFR_04970 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin AFR_04980 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AFR_04990 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AFR_05000 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AFR_05005 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme AFR_05025 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_05035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AFR_05040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFR_05045 ENOG4105C3U ABC transporter AFR_05050 ENOG4108JQ7 (ABC) transporter AFR_05060 ENOG4106D2I Chorismate mutase AFR_05075 ENOG4105E4C Lytic transglycosylase catalytic AFR_05080 ENOG41063SB peptidase AFR_05090 ENOG4105CMV Succinyl-CoA synthetase subunit beta AFR_05115 ENOG4105DC1 bifunctional purine biosynthesis protein purh AFR_05135 ENOG4105DGI Alkaline phosphatase AFR_05150 ENOG4105MVE transcriptional regulator AFR_05210 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) AFR_05230 ENOG4105CJ1 ABC, transporter AFR_05245 ENOG4108Z6Z Transcriptional regulator AFR_05250 ENOG4105EMU Dehydrogenase AFR_05255 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AFR_05270 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) AFR_05285 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AFR_05325 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AFR_05380 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_05410 ENOG4105CHU acetyl-coa acetyltransferase AFR_05445 ENOG4105BZU Histidine kinase AFR_05450 ENOG4107DKM chad domain containing protein AFR_05455 ENOG4105CSR polyphosphate kinase 2 AFR_05460 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AFR_05495 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AFR_05515 ENOG4105C7B Threonine dehydratase AFR_05520 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AFR_05530 ENOG4105T1M mycothiol conjugate amidase mca AFR_05540 ENOG4105BZU Histidine kinase AFR_05545 ENOG4105C7Z Conserved Protein AFR_05555 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AFR_05565 ENOG4105C6Y Udp-glucose 6-dehydrogenase AFR_05580 ENOG4108762 serine threonine protein kinase AFR_05620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AFR_05635 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AFR_05645 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) AFR_05650 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase AFR_05660 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) AFR_05665 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AFR_05680 ENOG4108ZJ4 polysaccharide deacetylase AFR_05695 ENOG4107RR1 TRANSCRIPTIONal AFR_05700 ENOG4105C26 Dehydrogenase AFR_05710 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) AFR_05715 ENOG4107QKV phosphomannomutase AFR_05720 ENOG4105W49 UPF0434 protein AFR_05735 ENOG4105EIP mannose-6-phosphate isomerase AFR_05755 ENOG410650H (LipO)protein AFR_05760 ENOG4105DBE peroxidase AFR_05765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_05770 ENOG4105BZU Histidine kinase AFR_05785 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea AFR_05790 ENOG4105D9U N-acetyltransferase AFR_05800 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AFR_05830 ENOG4105C26 Dehydrogenase AFR_05840 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AFR_05845 ENOG4105CAK Cell division ATP-binding protein ftsE AFR_05855 ENOG4105E4C Lytic transglycosylase catalytic AFR_05860 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AFR_05880 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_05890 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) AFR_05895 ENOG4108UJU UPF0301 protein AFR_05925 ENOG4105DYW oxidoreductase AFR_05930 ENOG4108WYP Transcriptional regulator AFR_05940 ENOG4107TXC Transcriptional regulator AFR_05980 ENOG4108VAU general secretion pathway protein G AFR_05985 ENOG4105D7Q type ii secretion system AFR_05990 ENOG4105CZX twitching motility protein AFR_05995 ENOG4107QHF type ii secretion system protein e AFR_06000 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AFR_06020 ENOG41082AN stage II sporulation protein AFR_06030 ENOG4105ETX regulatoR AFR_06035 ENOG4105BZU Histidine kinase AFR_06040 ENOG4105ETX regulatoR AFR_06055 ENOG4105BZU Histidine kinase AFR_06180 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AFR_06195 ENOG4106PGW Short-chain dehydrogenase reductase Sdr AFR_06210 ENOG4105ECQ AraC Family Transcriptional Regulator AFR_06225 ENOG4105BZU Histidine kinase AFR_06230 ENOG4108Z2K Cupin 2, conserved barrel domain protein AFR_06255 ENOG4105C5X domain protein AFR_06270 ENOG4105DQE DNA ligase AFR_06280 ENOG4105MSY salicylate hydroxylase AFR_06285 ENOG4105BZ9 Cytochrome C oxidase, subunit I AFR_06310 ENOG4108RWI nicotinamidase AFR_06315 ENOG4107RKP Nicotinate phosphoribosyltransferase AFR_06325 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AFR_06335 ENOG4108FN7 Aldo keto reductase AFR_06360 ENOG4108RQ5 Beta-lactamase domain-containing protein AFR_06365 ENOG4108MJN Glycosyl Transferase AFR_06370 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AFR_06375 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AFR_06405 ENOG4105C84 Histidine ammonia-lyase AFR_06410 ENOG4105CI2 imidazolone-5-propionate hydrolase AFR_06425 ENOG4105CGP Urocanate hydratase AFR_06470 ENOG4108W2P Methyl-accepting chemotaxis AFR_06510 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AFR_06615 ENOG4105BZU Histidine kinase AFR_06635 ENOG4105CJP fad dependent oxidoreductase AFR_06640 ENOG4105D38 putrescine abc transporter AFR_06645 ENOG4105F38 ABC transporter, permease AFR_06655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFR_06660 ENOG4105C26 Dehydrogenase AFR_06670 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AFR_06690 ENOG4105DU6 RNA polymerase AFR_06710 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_06715 ENOG4108XG2 Histidine kinase AFR_06725 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_06730 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_06750 ENOG4107UBC ErfK ybiS ycfS ynhG family protein AFR_06840 ENOG4108R5S membrane AFR_06865 ENOG4105RHY Pfam:UPF0157 AFR_06870 ENOG4105D7N magnesium and cobalt transport protein CorA AFR_06905 ENOG41082BM Transcriptional regulator, arsr family AFR_06915 ENOG4105PTV Nudix Hydrolase AFR_06925 ENOG4105E2D ec 3.2.1.52 AFR_06950 ENOG4105D29 Helix-turn-helix type 11 domain protein AFR_06995 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AFR_07030 ENOG4105FCW Major Facilitator superfamily AFR_07035 ENOG4105CG3 alpha amylase, catalytic region AFR_07045 ENOG4105BZU Histidine kinase AFR_07070 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AFR_07085 ENOG4105K4H Nlp p60 protein AFR_07090 ENOG4105WX6 Membrane AFR_07155 ENOG4108VB1 regulatoR AFR_07165 ENOG4108JQ1 Dehydrogenase AFR_07190 ENOG41061H0 Monooxygenase AFR_07205 ENOG4106F60 Histidine kinase AFR_07210 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_07225 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_07230 ENOG4107RBB ABC transporter, permease AFR_07245 ENOG4105CHP RNA polymerase AFR_07250 ENOG4108KPJ rna polymerase sigma factor AFR_07280 ENOG4105VHU single-stranded DNA-binding protein AFR_07285 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AFR_07290 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AFR_07300 ENOG4105D0M Protease HtpX homolog AFR_07305 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AFR_07325 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) AFR_07340 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AFR_07365 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AFR_07370 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AFR_07380 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AFR_07425 ENOG4105D8X mechanosensitive ion channel AFR_07455 ENOG4109057 AFR_07470 ENOG4105MC2 DSBA oxidoreductase AFR_07490 ENOG4108YZG isomerase AFR_07510 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AFR_07515 ENOG4105K4I Scp-like extracellular AFR_07535 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AFR_07540 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AFR_07545 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AFR_07550 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AFR_07580 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AFR_07585 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AFR_07610 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AFR_07625 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AFR_07635 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AFR_07645 ENOG4107R6F Alpha Beta Hydrolase Fold protein AFR_07650 ENOG4108Q50 Histidine kinase AFR_07670 ENOG4105C03 ribonuclease AFR_07680 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AFR_07685 ENOG4105K46 50S ribosomal protein l27 AFR_07690 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AFR_07695 ENOG4105I4A GCN5-related N-acetyltransferase AFR_07720 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AFR_07725 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AFR_07730 ENOG4105CVJ phosphoglycerate mutase AFR_07740 ENOG4105EPR degv family AFR_07750 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AFR_07755 ENOG4105KQC Competence protein AFR_07760 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AFR_07770 ENOG4105CWX Alpha-1,2-mannosidase AFR_07785 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AFR_07805 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AFR_07825 ENOG4106YT9 Enoyl-CoA hydratase AFR_07840 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AFR_07845 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AFR_07855 ENOG4105DQ5 transport system permease protein AFR_07860 ENOG4105TVJ transport system, permease AFR_07865 ENOG4105E0A ABC, transporter AFR_07880 ENOG4105BZ1 (ABC) transporter AFR_07895 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AFR_07905 ENOG4108KEZ Dehydrogenase AFR_07935 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AFR_07940 ENOG4105CHR reductase AFR_07945 ENOG4105K59 histidine triad (HIT) protein AFR_07960 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AFR_07975 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AFR_07995 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) AFR_08000 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AFR_08045 ENOG4108JJB ABC transporter AFR_08050 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein AFR_08055 ENOG4105CPT Alpha beta hydrolase AFR_08085 ENOG4105DIK (ABC) transporter AFR_08090 ENOG4105DSE periplasmic solute binding protein AFR_08110 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AFR_08115 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family AFR_08135 ENOG4105GWZ Roadblock lc7 family protein AFR_08160 ENOG4108NVR Methyl-accepting chemotaxis AFR_08165 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AFR_08170 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AFR_08195 ENOG4107S2Z UPF0761 membrane protein AFR_08200 ENOG4105DKQ ROK family AFR_08205 ENOG4105C2J ABC transporter AFR_08210 ENOG4105CNN ABC, transporter AFR_08260 ENOG4105CIH Imidazole acetol-phosphate transaminase AFR_08285 ENOG4108HMN Caspase domain AFR_08320 ENOG4108Z7F N-acetyltransferase AFR_08325 ENOG41082YX Transcriptional regulator, arsr family AFR_08445 ENOG4105D17 glycoside hydrolase, family 3 domain protein AFR_08455 ENOG4105C26 Dehydrogenase AFR_08465 ENOG410816E Phosphotransferase enzyme family AFR_08475 ENOG4106S2D Transcriptional regulator AFR_08505 ENOG4105CMT Dihydroxyacetone kinase AFR_08510 ENOG4105C75 arginyL-tRNA synthetase AFR_08535 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_08555 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AFR_08575 ENOG4107TPY serine threonine protein kinase AFR_08590 ENOG4105D9P serine threonine protein kinase AFR_08605 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) AFR_08645 ENOG4105EEM helicase AFR_08670 ENOG4105D17 glycoside hydrolase, family 3 domain protein AFR_08680 ENOG4105EE1 crotonyl-CoA reductase AFR_08690 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AFR_08695 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AFR_08735 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AFR_08745 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFR_08760 ENOG4105C8Q Methyl-accepting chemotaxis AFR_08765 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AFR_08770 ENOG4107ZED Uncharacterised protein family UPF0047 AFR_08780 ENOG4105CIG ABC transporter AFR_08810 ENOG4105CHR reductase AFR_08825 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AFR_08865 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_08890 ENOG4105EGD dinuclear metal center protein, YbgI family AFR_08900 ENOG4105CVJ phosphoglycerate mutase AFR_08925 ENOG4105EJ9 Membrane AFR_08970 ENOG4105C7B Threonine dehydratase AFR_08985 ENOG4106NZI LysR family Transcriptional regulator AFR_08995 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AFR_09025 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AFR_09035 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AFR_09040 ENOG4105C4K Nad synthetase AFR_09045 ENOG4105C5F glutamine synthetase AFR_09050 ENOG4105P3N Membrane AFR_09060 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_09070 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AFR_09080 ENOG4107JC6 Membrane AFR_09085 ENOG4107JC6 Membrane AFR_09120 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFR_09165 ENOG4105VF7 tolerance protein AFR_09205 ENOG4105CHP RNA polymerase AFR_09225 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AFR_09230 ENOG4105C5S asparaginyl-tRNA synthetase AFR_09240 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AFR_09270 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AFR_09275 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AFR_09280 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AFR_09285 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AFR_09295 ENOG4107XZ0 Peptidase M50 AFR_09300 ENOG4105CPC Aldo Keto reductase AFR_09320 ENOG4108IUW ABC transporter AFR_09330 ENOG4108UMN azlc family AFR_09345 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AFR_09350 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AFR_09360 ENOG4105BZW Glycerate kinase AFR_09380 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AFR_09385 ENOG4105C3J Cysteine desulfurase AFR_09390 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AFR_09395 ENOG4108ZRS Part of cytochrome c oxidase, its function is AFR_09405 ENOG4107S1N anthranilate phosphoribosyltransferase AFR_09425 ENOG4107UDY cytochrome C AFR_09435 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AFR_09455 ENOG4108S0S Nucleotidyl transferase AFR_09460 ENOG4105E09 nadh pyrophosphatase AFR_09465 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AFR_09485 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AFR_09490 ENOG4105JNK Glycosyl transferase (Group 1 AFR_09495 ENOG4105BZ1 (ABC) transporter AFR_09515 ENOG4105CJ1 ABC, transporter AFR_09535 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_09555 ENOG4105DKQ ROK family AFR_09565 ENOG4105H3G oxidoreductase AFR_09630 ENOG4105II7 pyrroline-5-carboxylate reductase AFR_09650 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase AFR_09665 ENOG4108JA1 polyketide synthase AFR_09685 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AFR_09780 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AFR_09790 ENOG4105E33 succinate dehydrogenase AFR_09850 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AFR_09910 ENOG4107VJY DNA polymerase AFR_09920 ENOG4105F8C transglutaminase domain-containing protein AFR_09930 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_09935 ENOG4105C8T Leucyl-tRNA synthetase AFR_09940 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AFR_09955 ENOG4105F1K Glutamine amidotransferase AFR_09960 ENOG4105DFU Cell wall formation (By similarity) AFR_09965 ENOG4105K4H Nlp p60 protein AFR_09970 ENOG4108V6E Cell division protein mraZ AFR_09975 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AFR_09985 ENOG4105CJN penicillin-binding protein AFR_09990 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AFR_10000 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AFR_10010 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AFR_10015 ENOG4105DFU Cell wall formation (By similarity) AFR_10025 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AFR_10030 ENOG4105DFA alanine racemase domain protein AFR_10035 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AFR_10060 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AFR_10070 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AFR_10090 ENOG4105C0B DNA polymerase III (alpha subunit) AFR_10105 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AFR_10110 ENOG4105CIH Imidazole acetol-phosphate transaminase AFR_10115 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AFR_10125 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AFR_10135 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AFR_10145 ENOG41080UQ Transcriptional regulator AFR_10150 ENOG4108594 Permease of the drug metabolite transporter AFR_10155 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AFR_10165 ENOG4108VW9 Membrane AFR_10170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFR_10175 ENOG4108ZJ4 polysaccharide deacetylase AFR_10190 ENOG4108KPJ rna polymerase sigma factor AFR_10195 ENOG4108IQE Amp-dependent synthetase and ligase AFR_10200 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AFR_10210 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_10215 ENOG41065SU Two-component system sensor kinase AFR_10220 ENOG4108KXV response regulator AFR_10245 ENOG4105BZ1 (ABC) transporter AFR_10250 ENOG4105BZ1 (ABC) transporter AFR_10255 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AFR_10275 ENOG4105CJ1 ABC, transporter AFR_10285 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AFR_10305 ENOG4105DK0 Indole-3-glycerol phosphate synthase AFR_10310 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AFR_10315 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AFR_10320 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AFR_10335 ENOG4105CBC glutamate synthase AFR_10395 ENOG4105C32 Amino acid ABC transporter (Permease) AFR_10400 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AFR_10405 ENOG4105C0Z ABC transporter AFR_10410 ENOG4108IV0 ABC, transporter AFR_10415 ENOG4107R0W ABC transporter AFR_10420 ENOG4105EAD ABC transporter AFR_10425 ENOG4105CDA abc transporter atp-binding protein AFR_10450 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_10455 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AFR_10460 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AFR_10480 ENOG41061CK Antibiotic biosynthesis monooxygenase AFR_10490 ENOG4105CI3 gtp-binding protein typa AFR_10500 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AFR_10505 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AFR_10510 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AFR_10515 ENOG4105C5X domain protein AFR_10525 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AFR_10535 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AFR_10545 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AFR_10550 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AFR_10560 ENOG4105CIE May be required for sporulation (By similarity) AFR_10565 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AFR_10570 ENOG4105BZA Phosphoglycerate kinase AFR_10575 ENOG4105CP7 Triose-phosphate isomerase AFR_10590 ENOG4108ZBR Gcn5-related n-acetyltransferase AFR_10600 ENOG4105NAF rna polymerase sigma factor AFR_10610 ENOG4105VS8 Flagellar biosynthetic protein fliq AFR_10615 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) AFR_10635 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AFR_10645 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AFR_10670 ENOG4105JRK feS assembly protein SufD AFR_10675 ENOG4105VQD rieske 2fe-2S domain-containing protein AFR_10680 ENOG4105C3K feS assembly ATPase SufC AFR_10685 ENOG4105C9B Cysteine desulfurase AFR_10690 ENOG4108UNV SUF system FeS assembly protein, NifU family AFR_10695 ENOG4105VG1 fes assembly suf system protein AFR_10700 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AFR_10705 ENOG4105CPQ Dehydrogenase AFR_10710 ENOG4105ERH Fumarylacetoacetate hydrolase AFR_10715 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AFR_10720 ENOG4105J4Q Transcriptional regulator AFR_10725 ENOG4105C01 Dihydroxy-acid dehydratase AFR_10775 ENOG4105CGZ zinc metallopeptidase AFR_10780 ENOG4105C5H ABC transporter AFR_10790 ENOG4105E39 Enoyl-CoA hydratase AFR_10795 ENOG4105BZ1 (ABC) transporter AFR_10810 ENOG41068WN AFR_10840 ENOG4108VCA G U mismatch-specific DNA glycosylase AFR_10850 ENOG4105CHR reductase AFR_10875 ENOG4105CHR reductase AFR_10885 ENOG4105E18 UPF0276 protein AFR_10895 ENOG4108Q5F Tetr family transcriptional regulator AFR_10925 ENOG4107NHD transcriptional regulator AFR_10930 ENOG4107QM5 aconitate hydratase AFR_10960 ENOG41067SE Tetr family transcriptional regulator AFR_10970 ENOG4107T6F Xaa-Pro aminopeptidase AFR_11005 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_11030 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_11035 ENOG4108ZGX Histidine kinase AFR_11055 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AFR_11065 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AFR_11075 ENOG4105C8Q Methyl-accepting chemotaxis AFR_11085 ENOG4105E1F short-chain dehydrogenase reductase AFR_11090 ENOG4105E09 nadh pyrophosphatase AFR_11095 ENOG4108UF8 AFR_11145 ENOG4108YYQ gCN5-related N-acetyltransferase AFR_11150 ENOG4105C87 Aminotransferase class I and II AFR_11170 ENOG410783G AFR_11175 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AFR_11185 ENOG4107FKK extracellular solute-binding protein family 1 AFR_11220 ENOG4106UW1 Major Facilitator superfamily AFR_11225 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AFR_11235 ENOG4105C2M dna polymerase I AFR_11245 ENOG4105C1G acyl-Coa dehydrogenase AFR_11265 ENOG4105GWZ Roadblock lc7 family protein AFR_11270 ENOG4105BZU Histidine kinase AFR_11275 ENOG4107RH1 pyridoxal-5'-phosphate-dependent protein beta subunit AFR_11300 ENOG4105BZU Histidine kinase AFR_11305 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_11335 ENOG4105K56 Transcriptional regulator AFR_11340 ENOG4105CHR reductase AFR_11375 ENOG4105ECY inositol monophosphatase AFR_11440 ENOG4105CPC Aldo Keto reductase AFR_11445 ENOG4105BZU Histidine kinase AFR_11450 ENOG4108RQS Two component transcriptional regulator (Winged helix family AFR_11475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_11490 ENOG4105ETE Transcriptional regulator (LacI family AFR_11495 ENOG4105CG3 alpha amylase, catalytic region AFR_11515 ENOG4105KVH Transcriptional regulator AFR_11520 ENOG4107S5I aldo keto reductase AFR_11530 ENOG4108YYC ycei family AFR_11540 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_11550 ENOG4105CHM Aminotransferase AFR_11570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_11580 ENOG4107QJZ Glycosyl transferase, family 2 AFR_11615 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_11625 ENOG4107QQG Dehydrogenase AFR_11630 ENOG4105D3Q Sugar transferase AFR_11640 ENOG4105GRZ Ycii-related protein AFR_11655 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AFR_11660 ENOG4107RSM transcriptional regulator AFR_11705 ENOG4105D75 Capsular exopolysaccharide family AFR_11715 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AFR_11770 ENOG410841Q phosphoesterase PA-phosphatase related protein AFR_11800 ENOG410645S MarR family Transcriptional regulator AFR_11840 ENOG4105C9U ATP-dependent DNA helicase RecQ AFR_11845 ENOG4105KPY Small multidrug resistance protein AFR_11855 ENOG4107SM8 Adenylate Guanylate cyclase AFR_11895 ENOG4105CIR epoxide hydrolase AFR_11910 ENOG4105BZU Histidine kinase AFR_11915 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AFR_11920 ENOG4108M0I Transcriptional regulator AFR_11940 ENOG4105CHR reductase AFR_11955 ENOG4105F0K SARP family transcriptional regulator AFR_11960 ENOG4105CHR reductase AFR_11965 ENOG4108IG5 Transcriptional regulator AFR_12005 ENOG4105CIR epoxide hydrolase AFR_12020 ENOG4108NVR Methyl-accepting chemotaxis AFR_12025 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AFR_12050 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_12205 ENOG4108IXY short-chain dehydrogenase reductase AFR_12245 ENOG4105CPC Aldo Keto reductase AFR_12280 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_12295 ENOG4105ENX hydrolase AFR_12310 ENOG4107FCW Abortive infection protein AFR_12325 ENOG4105BZU Histidine kinase AFR_12355 ENOG4105CIR epoxide hydrolase AFR_12360 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_12380 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AFR_12385 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AFR_12395 ENOG4105EMN RNA polymerase sigma factor AFR_12435 ENOG4105BZU Histidine kinase AFR_12440 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_12515 ENOG4105BZU Histidine kinase AFR_12540 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_12555 ENOG4106T9R serine protease AFR_12565 ENOG4105CJ1 ABC, transporter AFR_12570 ENOG4105C2D reductase AFR_12575 ENOG4105C26 Dehydrogenase AFR_12610 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AFR_12625 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AFR_12630 ENOG4105E3J oxidoreductase AFR_12680 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) AFR_12695 ENOG4108JQ1 Dehydrogenase AFR_12705 ENOG4105DRR Transcriptional regulator, GntR family AFR_12710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AFR_12735 ENOG4105D7V transposase AFR_12740 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFR_12775 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AFR_12790 ENOG4105CJ1 ABC, transporter AFR_12805 ENOG4105CHR reductase AFR_12835 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) AFR_12850 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AFR_12895 ENOG4108W6C Dehydrogenase AFR_12915 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFR_12940 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_12985 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AFR_12990 ENOG4105CPC Aldo Keto reductase AFR_12995 ENOG41062JF Transcriptional regulator AFR_13010 ENOG4108SGK Tetr family transcriptional regulator AFR_13020 ENOG4107S9F NmrA family AFR_13030 ENOG4108W6C Dehydrogenase AFR_13070 ENOG4107R2W ABC transporter, permease AFR_13075 ENOG4105C2J ABC transporter AFR_13085 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) AFR_13130 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AFR_13150 ENOG4105ETX regulatoR AFR_13155 ENOG4105BZU Histidine kinase AFR_13170 ENOG4108VHC Short-chain dehydrogenase reductase Sdr AFR_13180 ENOG4105ETE Transcriptional regulator (LacI family AFR_13195 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AFR_13255 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AFR_13285 ENOG4107S5I aldo keto reductase AFR_13300 ENOG4105DEN Luciferase family AFR_13320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_13325 ENOG4105EB3 Histidine kinase AFR_13335 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_13340 ENOG4105EMU Dehydrogenase AFR_13355 ENOG4105CG3 alpha amylase, catalytic region AFR_13365 ENOG4105EMU Dehydrogenase AFR_13370 ENOG4105C5Q Transcriptional regulator AFR_13375 ENOG4108IG5 Transcriptional regulator AFR_13385 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFR_13405 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AFR_13420 ENOG4105C1G acyl-Coa dehydrogenase AFR_13445 ENOG4105GWZ Roadblock lc7 family protein AFR_13465 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AFR_13475 ENOG4105CPC Aldo Keto reductase AFR_13480 ENOG4107S5I aldo keto reductase AFR_13485 ENOG4105EMU Dehydrogenase AFR_13495 ENOG4105RQF LysR family Transcriptional regulator AFR_13505 ENOG4105F27 Major Facilitator AFR_13540 ENOG4105EMU Dehydrogenase AFR_13570 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AFR_13595 ENOG4105MKU Transcriptional regulator AFR_13610 ENOG4105EGE secreted protein AFR_13630 ENOG4107HY1 Dehydrogenase AFR_13655 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) AFR_13665 ENOG4108XG4 DNA-binding transcriptional regulator AFR_13740 ENOG4105BZU Histidine kinase AFR_13765 ENOG4107QZ7 Cellulose synthase catalytic subunit AFR_13785 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AFR_13810 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AFR_13820 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AFR_13870 ENOG4105DXX methyltransferase AFR_13880 ENOG4105MWK D-amino acid dehydrogenase, small subunit AFR_13890 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AFR_13920 ENOG4107R13 MMPL domain protein AFR_13935 ENOG4105MSY salicylate hydroxylase AFR_13940 ENOG4105BZU Histidine kinase AFR_13950 ENOG4108JGH Tetr family transcriptional regulator AFR_13970 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AFR_13975 ENOG4105K4I Scp-like extracellular AFR_13990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFR_14000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AFR_14045 ENOG4105DBE peroxidase AFR_14055 ENOG4105C0R drug resistance transporter emrb qaca subfamily AFR_14105 ENOG4105BZU Histidine kinase AFR_14120 ENOG4105C83 adenylosuccinate lyase AFR_14160 ENOG4105EN6 Membrane AFR_14175 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AFR_14180 ENOG4105C7K acetolactate synthase AFR_14185 ENOG4105BZU Histidine kinase AFR_14200 ENOG4105KME endoribonuclease L-psp AFR_14220 ENOG4105CPQ Dehydrogenase AFR_14270 ENOG4105BZ9 Cytochrome C oxidase, subunit I AFR_14275 ENOG4107R13 MMPL domain protein AFR_14280 ENOG4105CPQ Dehydrogenase AFR_14285 ENOG4107S21 permease AFR_14290 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AFR_14300 ENOG4105CIG ABC transporter AFR_14325 ENOG41080T7 secreted protein AFR_14335 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AFR_14345 ENOG4105C2C drug resistance transporter, Bcr CflA AFR_14360 ENOG4105I1K ABC transporter AFR_14385 ENOG4108JGH Tetr family transcriptional regulator AFR_14395 ENOG4108IND Tetr family transcriptional regulator AFR_14400 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AFR_14535 ENOG4105VEQ Cold shock protein AFR_14545 ENOG4105ECQ AraC Family Transcriptional Regulator AFR_14565 ENOG4108YIQ Alpha beta hydrolase AFR_14570 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AFR_14580 ENOG4105E7U AraC family transcriptional regulator AFR_14585 ENOG4108KC1 acyl-Coa dehydrogenase AFR_14590 ENOG4108JQ7 (ABC) transporter AFR_14595 ENOG4105C3U ABC transporter AFR_14600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFR_14605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AFR_14610 ENOG4105DEF Extracellular solute-binding protein, family 5 AFR_14615 ENOG4108IQE Amp-dependent synthetase and ligase AFR_14645 ENOG4105CYP glycoside hydrolase, family AFR_14665 ENOG4107SCK Monooxygenase AFR_14680 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AFR_14685 ENOG4105CIR epoxide hydrolase AFR_14705 ENOG4105EJ2 Transcriptional regulator AFR_14710 ENOG4107R16 Multicopper oxidase AFR_14725 ENOG4105CHR reductase AFR_14760 ENOG41066UM arsR family transcriptional regulator AFR_14785 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AFR_14790 ENOG4105EYF MMPL domain protein AFR_14805 ENOG4105BZU Histidine kinase AFR_14810 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_14815 ENOG4107MM9 BNR Asp-box repeat-containing protein AFR_14860 ENOG4108YIQ Alpha beta hydrolase AFR_14885 ENOG4108KEZ Dehydrogenase AFR_14895 ENOG4105CYP glycoside hydrolase, family AFR_14935 ENOG4107TPY serine threonine protein kinase AFR_14940 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AFR_14945 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 AFR_14955 ENOG4105DRS transport system, permease AFR_14960 ENOG4105D56 permease protein AFR_14975 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AFR_15025 ENOG4105CIR epoxide hydrolase AFR_15045 ENOG4106F60 Histidine kinase AFR_15050 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_15055 ENOG4105CJ1 ABC, transporter AFR_15085 ENOG4105CHP RNA polymerase AFR_15100 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AFR_15105 ENOG4107S5I aldo keto reductase AFR_15110 ENOG4105DQ4 alcohol dehydrogenase AFR_15120 ENOG4105KVH Transcriptional regulator AFR_15145 ENOG4107RSM transcriptional regulator AFR_15165 ENOG4105CKW Inner membrane protein yedI AFR_15210 ENOG4105F6S Spore photoproduct lyase AFR_15245 ENOG4105CF7 AraC family transcriptional regulator AFR_15270 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AFR_15280 ENOG4105KVH Transcriptional regulator AFR_15290 ENOG4105D3P Mannan endo-1,4-beta-mannosidase AFR_15300 ENOG4105EG2 ABC transporter, permease AFR_15315 ENOG4105ETE Transcriptional regulator (LacI family AFR_15345 ENOG4105CPQ Dehydrogenase AFR_15355 ENOG4105BZ4 penicillin-binding protein AFR_15370 ENOG4107SFI Major Facilitator superfamily AFR_15390 ENOG4105BZU Histidine kinase AFR_15415 ENOG4105F6J Alpha beta hydrolase fold AFR_15425 ENOG41062D9 Histidine kinase AFR_15430 ENOG4105ETX regulatoR AFR_15450 ENOG4108W6C Dehydrogenase AFR_15455 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AFR_15490 ENOG4105CWX Alpha-1,2-mannosidase AFR_15510 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AFR_15530 ENOG4105CD8 aminopeptidase N AFR_15590 ENOG4107SYN Glycosyl hydrolases family 43 AFR_15600 ENOG41086D8 Transcriptional regulator AFR_15645 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AFR_15665 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AFR_15680 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFR_15685 ENOG4105D38 putrescine abc transporter AFR_15700 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AFR_15710 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AFR_15715 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AFR_15730 ENOG4105F95 Monooxygenase AFR_15765 ENOG4105C2C drug resistance transporter, Bcr CflA AFR_15790 ENOG4105DXX methyltransferase AFR_15795 ENOG4108J20 pectate lyase AFR_15800 ENOG4108VQT Alpha beta hydrolase fold protein AFR_15805 ENOG4108K8S endonuclease I AFR_15810 ENOG4105CYW agmatinase AFR_15840 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AFR_15845 ENOG4105CPC Aldo Keto reductase AFR_15850 ENOG4108SGK Tetr family transcriptional regulator AFR_15875 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AFR_15880 ENOG4108MRH transcriptional regulatory protein AFR_15890 ENOG4105J5G Transferase hexapeptide repeat containing protein AFR_15895 ENOG4105D9R oxidoreductase AFR_15900 ENOG4105CMR udp-glucose 4-epimerase AFR_15940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AFR_15945 ENOG4105CEY Amp-dependent synthetase and ligase AFR_15970 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AFR_15975 ENOG4105K64 Glycosyl transferase, family 2 AFR_15995 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_16015 ENOG4105C6Y Udp-glucose 6-dehydrogenase AFR_16020 ENOG4105D3Q Sugar transferase AFR_16065 ENOG4108W9H Tetr family transcriptional regulator AFR_16070 ENOG4107S9B Shikimate dehydrogenase AFR_16120 ENOG4105F7P transcriptional regulator AsnC family AFR_16135 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AFR_16145 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_16150 ENOG4105BZU Histidine kinase AFR_16155 ENOG4107R13 MMPL domain protein AFR_16165 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AFR_16205 ENOG4105CPC Aldo Keto reductase AFR_16215 ENOG4105DFW ABC transporter AFR_16220 ENOG4105C2J ABC transporter AFR_16225 ENOG4107RNG ABC transporter AFR_16230 ENOG4105E2R ROK family AFR_16255 ENOG4108S01 response regulator AFR_16270 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) AFR_16280 ENOG4105E6M Sulphatase-modifying factor protein AFR_16295 ENOG4105DEG Vwa containing coxe family protein AFR_16300 ENOG4105KKX ATPase associated with various cellular activities aaa_5 AFR_16345 ENOG4105CJN penicillin-binding protein AFR_16355 ENOG4105C5Q Transcriptional regulator AFR_16360 ENOG4105EMU Dehydrogenase AFR_16375 ENOG4105CMT Dihydroxyacetone kinase AFR_16380 ENOG4108UTZ Dihydroxyacetone kinase AFR_16385 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AFR_16445 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) AFR_16460 ENOG4105CUB amino acid AFR_16475 ENOG4108RZE Tetr family transcriptional regulator AFR_16505 ENOG4105C6Y Udp-glucose 6-dehydrogenase AFR_16520 ENOG4107QZ7 Cellulose synthase catalytic subunit AFR_16545 ENOG4105C84 Histidine ammonia-lyase AFR_16580 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase AFR_16585 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AFR_16590 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AFR_16595 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_16605 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AFR_16620 ENOG4105C26 Dehydrogenase AFR_16640 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AFR_16645 ENOG4105E0A ABC, transporter AFR_16650 ENOG4105J76 Periplasmic binding protein AFR_16655 ENOG4105S6R Iron-hydroxamate transporter permease subunit AFR_16670 ENOG4105BZN citrate synthase AFR_16715 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AFR_16725 ENOG4107RBB ABC transporter, permease AFR_16730 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_16755 ENOG4105NAF rna polymerase sigma factor AFR_16760 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AFR_16775 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AFR_16785 ENOG4105ENE Histidine kinase AFR_16790 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_16800 ENOG4105C3S Mate efflux family protein AFR_16815 ENOG4105ETE Transcriptional regulator (LacI family AFR_16830 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AFR_16845 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AFR_16860 ENOG4105D2H Uronic isomerase AFR_16865 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AFR_16870 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AFR_16910 ENOG4105C26 Dehydrogenase AFR_16915 ENOG4105EW9 transcriptional regulator AsnC family AFR_16925 ENOG4105CPP Dehydrogenase, E1 component AFR_16930 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 AFR_16945 ENOG4105ETE Transcriptional regulator (LacI family AFR_16955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AFR_16995 ENOG4105BZU Histidine kinase AFR_17000 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AFR_17015 ENOG4105D9P serine threonine protein kinase AFR_17040 ENOG4105EMN RNA polymerase sigma factor AFR_17075 ENOG4105NAE bifunctional deaminase-reductase domain protein AFR_17085 ENOG4105BZU Histidine kinase AFR_17090 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AFR_17095 ENOG4107Y80 Major Facilitator superfamily AFR_17105 ENOG4105EX0 alpha-galactosidase AFR_17115 ENOG4107T5V SNARE associated Golgi AFR_17130 ENOG4105CEP NADH dehydrogenase AFR_17150 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator AFR_17155 ENOG4105CNN ABC, transporter AFR_17160 ENOG4105C2J ABC transporter AFR_17165 ENOG4107Z1W Fructose transport system kinase AFR_17170 ENOG4105CHR reductase AFR_17185 ENOG4105BZU Histidine kinase AFR_17210 ENOG4105VMP Transcriptional regulator AFR_17220 ENOG4108YYH Nadph-dependent fmn reductase AFR_17260 ENOG4107SCA Formamidase (EC 3.5.1.49) AFR_17290 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AFR_17315 ENOG4107RBB ABC transporter, permease AFR_17320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_17335 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_17340 ENOG4106F60 Histidine kinase AFR_17345 ENOG4105BZU Histidine kinase AFR_17355 ENOG4105C3Q Glycosyl transferase, family 2 AFR_17360 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AFR_17370 ENOG4105BZU Histidine kinase AFR_17380 ENOG4105BZU Histidine kinase AFR_17520 ENOG4105EGE secreted protein AFR_17525 ENOG4105ETE Transcriptional regulator (LacI family AFR_17530 ENOG4107TPY serine threonine protein kinase AFR_17565 ENOG4105NBR Pectinesterase AFR_17570 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AFR_17575 ENOG4108PVQ transcriptional regulator AFR_17580 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AFR_17595 ENOG4108UAU isochorismatase AFR_17600 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AFR_17605 ENOG4105DAG ROK family AFR_17620 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AFR_17645 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AFR_17650 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_17655 ENOG4105BZU Histidine kinase AFR_17690 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AFR_17700 ENOG4105KXX peptidase s58 dmpa AFR_17750 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AFR_17800 ENOG4105BZU Histidine kinase AFR_17805 ENOG4107S2E monooxygenase AFR_17840 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) AFR_17850 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_17860 ENOG4107RSM transcriptional regulator AFR_17865 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) AFR_17875 ENOG4105DBA pectate lyase AFR_17905 ENOG4105BZF Glycosyl transferase (Group 1 AFR_17915 ENOG4105CQB FAD linked oxidase domain protein AFR_17920 ENOG4105KVH Transcriptional regulator AFR_17925 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AFR_17930 ENOG4106P55 Transcriptional regulator AFR_17955 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) AFR_17960 ENOG4105C39 capsular polysaccharide phosphotransferase AFR_17980 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AFR_17990 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AFR_18000 ENOG4105ETE Transcriptional regulator (LacI family AFR_18035 ENOG4107S46 esterase, PHB depolymerase AFR_18045 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AFR_18050 ENOG4105NAE bifunctional deaminase-reductase domain protein AFR_18060 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AFR_18065 ENOG4105CPC Aldo Keto reductase AFR_18070 ENOG4105W1N transcriptional regulator AFR_18100 ENOG4107S5I aldo keto reductase AFR_18120 ENOG4105CHR reductase AFR_18140 ENOG4105BZU Histidine kinase AFR_18185 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AFR_18215 ENOG4108IJ9 (ABC) transporter AFR_18220 ENOG4105D38 putrescine abc transporter AFR_18250 ENOG4105EG6 Saccharopine dehydrogenase AFR_18255 ENOG4105BZU Histidine kinase AFR_18260 ENOG4105C2D reductase AFR_18280 ENOG41060NJ transcriptional regulator AFR_18305 ENOG4105ETE Transcriptional regulator (LacI family AFR_18325 ENOG4105C0Z ABC transporter AFR_18330 ENOG4108IV0 ABC, transporter AFR_18380 ENOG4105BZ1 (ABC) transporter AFR_18385 ENOG4105CYW agmatinase AFR_18425 ENOG4105DVW rieske (2Fe-2S) AFR_18430 ENOG4105F76 Sarcosine oxidase AFR_18450 ENOG4108IJ7 Glycine betaine AFR_18460 ENOG4107T5V SNARE associated Golgi AFR_18495 ENOG4105JZC GHMP kinase AFR_18520 ENOG4107RCI amp-dependent synthetase and ligase AFR_18525 ENOG4105C1G acyl-Coa dehydrogenase AFR_18540 ENOG4105CEY Amp-dependent synthetase and ligase AFR_18550 ENOG4105CEY Amp-dependent synthetase and ligase AFR_18575 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_18580 ENOG4108ZGX Histidine kinase AFR_18590 ENOG4105C57 major facilitator superfamily AFR_18595 ENOG4108JGH Tetr family transcriptional regulator AFR_18610 ENOG4107RDB Major Facilitator AFR_18620 ENOG4106TD9 Diguanylate cyclase AFR_18640 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AFR_18650 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AFR_18685 ENOG4108IFG nitrite reductase, (NAD(P)H) AFR_18690 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AFR_18695 ENOG4105DQQ Major facilitator superfamily MFS_1 AFR_18710 ENOG4107QKS N-acylglucosamine 2-epimerase AFR_18755 ENOG4105F1N DNA alkylation repair AFR_18760 ENOG4107ZXU DSBA oxidoreductase AFR_18795 ENOG4105DSE periplasmic solute binding protein AFR_18800 ENOG4105DIK (ABC) transporter AFR_18860 ENOG4105DTQ mandelate racemase muconate lactonizing AFR_18880 ENOG4105C4C beta-galactosidase AFR_18910 ENOG4105BZU Histidine kinase AFR_18925 ENOG4105CYP glycoside hydrolase, family AFR_18935 ENOG4105ETE Transcriptional regulator (LacI family AFR_18940 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator AFR_18945 ENOG4105C2J ABC transporter AFR_18950 ENOG4107R9N ABC transporter AFR_18955 ENOG41062B0 ABC transporter, permease AFR_18965 ENOG4108Z6B deaminase AFR_18970 ENOG4105DEN Luciferase family AFR_18980 ENOG4105C57 major facilitator superfamily AFR_18995 ENOG4105NRA 50s ribosomal protein l31 type b AFR_19005 ENOG4105EZM VWA-like domain (DUF2201) AFR_19035 ENOG4105C7W Xanthine dehydrogenase AFR_19040 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding AFR_19045 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AFR_19080 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AFR_19125 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AFR_19140 ENOG4105CF7 AraC family transcriptional regulator AFR_19145 ENOG4105CPC Aldo Keto reductase AFR_19165 ENOG4105BZU Histidine kinase AFR_19180 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AFR_19185 ENOG4105VS8 Flagellar biosynthetic protein fliq AFR_19190 ENOG4105NGS secreted protein AFR_19230 ENOG41065SU Two-component system sensor kinase AFR_19235 ENOG4108KXV response regulator AFR_19250 ENOG4105BZU Histidine kinase AFR_19255 ENOG4107HP6 Transcriptional regulator AFR_19260 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AFR_19265 ENOG4105F2Z 3-oxoadipate enol-lactonase AFR_19270 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AFR_19305 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AFR_19310 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AFR_19325 ENOG4105D74 hydrolase AFR_19335 ENOG4105I1K ABC transporter AFR_19340 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component AFR_19395 ENOG4105D56 permease protein AFR_19400 ENOG4105EG2 ABC transporter, permease AFR_19405 ENOG4105EE1 crotonyl-CoA reductase AFR_19420 ENOG4105W1N transcriptional regulator AFR_19435 ENOG4105F27 Major Facilitator AFR_19440 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AFR_19445 ENOG4107S5I aldo keto reductase AFR_19450 ENOG4105DUX Transporter AFR_19455 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AFR_19460 ENOG4105FQP Beta-lactamase AFR_19470 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_19475 ENOG4106F60 Histidine kinase AFR_19490 ENOG4105C8M UPF0272 protein AFR_19495 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase AFR_19500 ENOG4105DVM PP-loop domain protein AFR_19505 ENOG4105ETE Transcriptional regulator (LacI family AFR_19520 ENOG4105CHU acetyl-coa acetyltransferase AFR_19525 ENOG4108JJB ABC transporter AFR_19540 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AFR_19565 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AFR_19580 ENOG4105CX8 fg-gap repeat protein AFR_19585 ENOG4105IIP Membrane AFR_19590 ENOG4105W1N transcriptional regulator AFR_19595 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AFR_19600 ENOG4105CQB FAD linked oxidase domain protein AFR_19605 ENOG4105CQB FAD linked oxidase domain protein AFR_19620 ENOG4105E2A Dehydrogenase AFR_19660 ENOG4105CHP RNA polymerase AFR_19665 ENOG4105CHF Glutathione S-transferase AFR_19670 ENOG4105D58 Diguanylate phosphodiesterase AFR_19675 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFR_19690 ENOG4105C9U ATP-dependent DNA helicase RecQ AFR_19700 ENOG41090CE integral membrane protein AFR_19710 ENOG4108Q50 Histidine kinase AFR_19715 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AFR_19735 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_19750 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AFR_19755 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AFR_19775 ENOG4105C2W permease AFR_19785 ENOG4108Z6Z Transcriptional regulator AFR_19820 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AFR_19830 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AFR_19865 ENOG4108MGF sugar kinase AFR_19880 ENOG4105C57 major facilitator superfamily AFR_19890 ENOG41067SE Tetr family transcriptional regulator AFR_19900 ENOG4105C6Z Gluconate AFR_19910 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_19920 ENOG4105BZU Histidine kinase AFR_19925 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AFR_19945 ENOG4105BZ4 penicillin-binding protein AFR_19950 ENOG4108MRH transcriptional regulatory protein AFR_19955 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AFR_19960 ENOG4107QJT sodium dicarboxylate symporter AFR_19970 ENOG4105ETE Transcriptional regulator (LacI family AFR_19975 ENOG4107R72 Ceramidase AFR_20000 ENOG4105CHH sulfate transporter AFR_20020 ENOG4105JVQ RNA Polymerase AFR_20045 ENOG4105BZ1 (ABC) transporter AFR_20050 ENOG4105BZ1 (ABC) transporter AFR_20080 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AFR_20105 ENOG4105BZU Histidine kinase AFR_20135 ENOG4108JJ9 ABC, transporter AFR_20140 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AFR_20145 ENOG4105C4M (Ubiquinol oxidase) subunit I AFR_20160 ENOG4105K4H Nlp p60 protein AFR_20165 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase AFR_20170 ENOG4105FS7 Transcriptional regulator AFR_20175 ENOG4105CIR epoxide hydrolase AFR_20180 ENOG4105BZU Histidine kinase AFR_20185 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AFR_20195 ENOG4108J2P Alpha beta hydrolase fold AFR_20200 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AFR_20250 ENOG4105FDP GntR family transcriptional regulator AFR_20255 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AFR_20260 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AFR_20280 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_20285 ENOG4108ZGX Histidine kinase AFR_20290 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AFR_20315 ENOG4105ETX regulatoR AFR_20320 ENOG41062D9 Histidine kinase AFR_20335 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFR_20355 ENOG41082YX Transcriptional regulator, arsr family AFR_20375 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_20380 ENOG4105BZU Histidine kinase AFR_20405 ENOG4105BZU Histidine kinase AFR_20410 ENOG4105CH6 catalase AFR_20425 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AFR_20430 ENOG4108UMI ABC transporter, permease AFR_20435 ENOG4105D01 (LipO)protein AFR_20450 ENOG4107QP8 phosphohexose isomerase AFR_20465 ENOG4108NIW Leucine export protein LeuE AFR_20475 ENOG4108UZX fmn reductase AFR_20480 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AFR_20490 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AFR_20500 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) AFR_20505 ENOG4105F27 Major Facilitator AFR_20510 ENOG4105CXK mandelate racemase muconate lactonizing AFR_20515 ENOG4108I5D sulfate abc transporter AFR_20525 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFR_20535 ENOG4105ETE Transcriptional regulator (LacI family AFR_20540 ENOG41060NJ transcriptional regulator AFR_20565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_20570 ENOG4105BZU Histidine kinase AFR_20580 ENOG4105C19 ABC transporter AFR_20585 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_20625 ENOG4105DU1 integral membrane protein, terc AFR_20630 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AFR_20670 ENOG4105W1N transcriptional regulator AFR_20685 ENOG4105EDK PfkB domain protein AFR_20695 ENOG4105DH8 myo-inositol catabolism AFR_20700 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AFR_20705 ENOG4105C26 Dehydrogenase AFR_20720 ENOG41062B0 ABC transporter, permease AFR_20725 ENOG4105C2J ABC transporter AFR_20735 ENOG4105F0H myo-inositol catabolism protein AFR_20745 ENOG4105CK5 oxidoreductase AFR_20750 ENOG4105ETE Transcriptional regulator (LacI family AFR_20755 ENOG4105CDV Ompa motb domain protein AFR_20760 ENOG4107QP6 Xylose isomerase domain protein TIM barrel AFR_20770 ENOG41060NJ transcriptional regulator AFR_20780 ENOG4108IG5 Transcriptional regulator AFR_20785 ENOG4108ZJI phenylacetic acid degradation protein AFR_20795 ENOG4105CHU acetyl-coa acetyltransferase AFR_20800 ENOG4105E39 Enoyl-CoA hydratase AFR_20805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AFR_20810 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AFR_20815 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AFR_20820 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AFR_20825 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AFR_20830 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AFR_20845 ENOG4105CPC Aldo Keto reductase AFR_20850 ENOG4105BZU Histidine kinase AFR_20855 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_20885 ENOG4105K6V RNA polymerase AFR_20895 ENOG4105EYF MMPL domain protein AFR_20905 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_20915 ENOG4105CJ1 ABC, transporter AFR_20950 ENOG4108IJ6 ABC transporter AFR_21020 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AFR_21025 ENOG4107QPH glycogen) synthase AFR_21035 ENOG4105F32 YngK protein AFR_21040 ENOG4105C5H ABC transporter AFR_21045 ENOG4105JAB phenazine biosynthesis protein, phzf family AFR_21050 ENOG4105EET magnesium chelatase AFR_21055 ENOG4107KWJ von Willebrand factor, type A AFR_21085 ENOG4108UW8 fha domain-containing protein AFR_21105 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AFR_21120 ENOG4105DDW LysR family Transcriptional regulator AFR_21130 ENOG4105VEQ Cold shock protein AFR_21135 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AFR_21155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_21160 ENOG4105EB3 Histidine kinase AFR_21190 ENOG4105CPC Aldo Keto reductase AFR_21195 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AFR_21205 ENOG4105CRQ synthase (Component I) AFR_21220 ENOG4105JVQ RNA Polymerase AFR_21225 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AFR_21235 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AFR_21240 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AFR_21265 ENOG4108M15 ABC transporter AFR_21275 ENOG4105BZU Histidine kinase AFR_21280 ENOG4108S01 response regulator AFR_21285 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFR_21300 ENOG4105C5H ABC transporter AFR_21305 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFR_21310 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AFR_21360 ENOG4105DEU major facilitator superfamily AFR_21385 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_21410 ENOG4108ME1 Peptidase M55 D-aminopeptidase AFR_21415 ENOG4105PSQ Acyl-transferase AFR_21435 ENOG4105F0K SARP family transcriptional regulator AFR_21445 ENOG4105CHR reductase AFR_21455 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFR_21460 ENOG4105Y7M Transcriptional regulator, TetR family AFR_21485 ENOG4108ZHJ Organic hydroperoxide resistance protein AFR_21490 ENOG4105K56 Transcriptional regulator AFR_21505 ENOG41090KN UPF0303 protein AFR_21525 ENOG4105DYW oxidoreductase AFR_21560 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_21575 ENOG4105BZU Histidine kinase AFR_21580 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_21635 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AFR_21645 ENOG4105BZU Histidine kinase AFR_21665 ENOG4105ETE Transcriptional regulator (LacI family AFR_21680 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AFR_21695 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_21700 ENOG4105BZU Histidine kinase AFR_21715 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid AFR_21720 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AFR_21765 ENOG4105BZU Histidine kinase AFR_21775 ENOG4105Q70 AFR_21785 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AFR_21800 ENOG4108UYI beta-alanyl-CoA ammonia lyase AFR_21805 ENOG4107CHF 5,6-aminomutase beta subunit AFR_21810 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit AFR_21820 ENOG4105FRY Dehydrogenase AFR_21825 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AFR_21830 ENOG4108J08 Csbd family AFR_21855 ENOG4105J0Q Transcriptional regulator AFR_21860 ENOG4105C1G acyl-Coa dehydrogenase AFR_21865 ENOG4105HFS 5'-3' exonuclease AFR_21880 ENOG4105XEA Tetr family transcriptional regulator AFR_21885 ENOG4105FBA Phospholipase Carboxylesterase AFR_21895 ENOG4105BZU Histidine kinase AFR_21925 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_21995 ENOG4105WEF catalase AFR_22015 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AFR_22020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_22095 ENOG4107SFI Major Facilitator superfamily AFR_22100 ENOG4105EGE secreted protein AFR_22140 ENOG4105PDP Short chain dehydrogenase AFR_22235 ENOG4108WAV Transcriptional regulator AFR_22250 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AFR_22255 ENOG4105E2Y ABC, transporter AFR_22265 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AFR_22280 ENOG4105CQB FAD linked oxidase domain protein AFR_22295 ENOG4105KME endoribonuclease L-psp AFR_22300 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AFR_22305 ENOG4105GVF (ABC) transporter AFR_22310 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AFR_22315 ENOG4105E2Y ABC, transporter AFR_22320 ENOG4108Z12 YiaAB two helix domain-containing protein AFR_22335 ENOG4108IYU L-aspartate oxidase AFR_22340 ENOG4105DEN Luciferase family AFR_22345 ENOG4105DEN Luciferase family AFR_22350 ENOG4105CPU Monooxygenase AFR_22355 ENOG4105CPU Monooxygenase AFR_22365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFR_22375 ENOG4105DEF Extracellular solute-binding protein, family 5 AFR_22405 ENOG4105CUB amino acid AFR_22415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AFR_22430 ENOG4105CJQ hydrolase, family 31 AFR_22440 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component AFR_22460 ENOG4105ETE Transcriptional regulator (LacI family AFR_22480 ENOG41087PP glycosyltransferase MGT family AFR_22490 ENOG4105D2N Aldolase AFR_22495 ENOG4105DE4 1-phosphofructokinase AFR_22505 ENOG4105D7K pfkb domain protein AFR_22530 ENOG4105DRS transport system, permease AFR_22540 ENOG4107FKK extracellular solute-binding protein family 1 AFR_22545 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AFR_22555 ENOG4105E98 transcriptional regulator DeoR family AFR_22580 ENOG4108XG4 DNA-binding transcriptional regulator AFR_22615 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AFR_22620 ENOG4107TXC Transcriptional regulator AFR_22695 ENOG41061H0 Monooxygenase AFR_22725 ENOG4105C6Y Udp-glucose 6-dehydrogenase AFR_22740 ENOG4108Z6Z Transcriptional regulator AFR_22745 ENOG4105CVM Molybdenum cofactor synthesis domain protein AFR_22750 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_22765 ENOG4105C8Q Methyl-accepting chemotaxis AFR_22770 ENOG4105BZU Histidine kinase AFR_22785 ENOG4105C7W Xanthine dehydrogenase AFR_22810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_22815 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AFR_22820 ENOG4105EMN RNA polymerase sigma factor AFR_22875 ENOG4105D78 K07001 NTE family protein AFR_22880 ENOG4107QRI Phosphoketolase AFR_22890 ENOG4108FN7 Aldo keto reductase AFR_22900 ENOG4105ECY inositol monophosphatase AFR_22915 ENOG4105C57 major facilitator superfamily AFR_22970 ENOG4107SMB hydrolase Family 5 AFR_22975 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase AFR_22980 ENOG41060BG Tetr family transcriptional regulator AFR_22995 ENOG41084GC stage II sporulation protein AFR_23005 ENOG4105CGD Nad-dependent epimerase dehydratase AFR_23010 ENOG4105XEA Tetr family transcriptional regulator AFR_23020 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AFR_23025 ENOG4105CHR reductase AFR_23040 ENOG4105EMU Dehydrogenase AFR_23055 ENOG4105CIR epoxide hydrolase AFR_23060 ENOG4105CIR epoxide hydrolase AFR_23125 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) AFR_23145 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AFR_23225 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 AFR_23235 ENOG4105CMT Dihydroxyacetone kinase AFR_23245 ENOG41082YX Transcriptional regulator, arsr family AFR_23265 ENOG4105FDF Could be involved in DNA repair (By similarity) AFR_23305 ENOG4107XZA Glycosyl transferase family 2 AFR_23310 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AFR_23315 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_23335 ENOG4105JEU Glycosyl transferase, family 2 AFR_23340 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AFR_23385 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AFR_23415 ENOG4105CPQ Dehydrogenase AFR_23430 ENOG4105EEM helicase AFR_23450 ENOG4108KPJ rna polymerase sigma factor AFR_23470 ENOG4105EB3 Histidine kinase AFR_23520 ENOG4105NPE arsR family transcriptional regulator AFR_23535 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AFR_23540 ENOG4105CIR epoxide hydrolase AFR_23560 ENOG4108RZ2 Glycoside hydrolase family 16 AFR_23580 ENOG4105F9F transposase AFR_23620 ENOG4105DQ5 transport system permease protein AFR_23625 ENOG4105TVJ transport system, permease AFR_23630 ENOG4105E0A ABC, transporter AFR_23640 ENOG4105BZ1 (ABC) transporter AFR_23645 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AFR_23650 ENOG4105C5Q Transcriptional regulator AFR_23685 ENOG4107EFR Flavocytochrome c AFR_23695 ENOG4107HP6 Transcriptional regulator AFR_23715 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) AFR_23735 ENOG4105CMR udp-glucose 4-epimerase AFR_23745 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AFR_23755 ENOG4105IKQ hydratase AFR_23760 ENOG4107HP6 Transcriptional regulator AFR_23795 ENOG4105DBI uridine monophosphokinase AFR_23800 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AFR_23835 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFR_23860 ENOG4108IXY short-chain dehydrogenase reductase AFR_23870 ENOG4105JVQ RNA Polymerase AFR_23915 ENOG4105GFR rna polymerase sigma factor AFR_23920 ENOG4105GRZ Ycii-related protein AFR_23925 ENOG4105CHP RNA polymerase AFR_23930 ENOG4105K56 Transcriptional regulator AFR_23935 ENOG4105DXC membrane AFR_23940 ENOG4105DU1 integral membrane protein, terc AFR_23950 ENOG4108W5M transcriptional regulator AFR_23965 ENOG4105EPJ extracellular solute-binding protein family 1 AFR_23970 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component AFR_23975 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AFR_24000 ENOG4108JA5 May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity) AFR_24020 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AFR_24035 ENOG4108ZHR arsR family transcriptional regulator AFR_24055 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AFR_24060 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_24065 ENOG4106F60 Histidine kinase AFR_24115 ENOG4105BZU Histidine kinase AFR_24120 ENOG4105DAA L-lactate AFR_24190 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) AFR_24195 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_24205 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_24220 ENOG4108IG5 Transcriptional regulator AFR_24230 ENOG4108JQ6 ABC transporter AFR_24240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFR_24245 ENOG4105DEF Extracellular solute-binding protein, family 5 AFR_24305 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AFR_24310 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AFR_24335 ENOG4108Q5F Tetr family transcriptional regulator AFR_24340 ENOG4108IXY short-chain dehydrogenase reductase AFR_24395 ENOG4105C4Y ABC transporter AFR_24400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_24405 ENOG4105ES5 Histidine kinase AFR_24420 ENOG4106FTQ Taurine ABC transporter, periplasmic AFR_24425 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AFR_24435 ENOG4105GRZ Ycii-related protein AFR_24440 ENOG4105CHP RNA polymerase AFR_24445 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_24510 ENOG4105ETE Transcriptional regulator (LacI family AFR_24520 ENOG4105BZU Histidine kinase AFR_24530 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_24540 ENOG4107T8P acyl-Coa dehydrogenase AFR_24545 ENOG4108PJD permease AFR_24570 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AFR_24600 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_24620 ENOG4105EMN RNA polymerase sigma factor AFR_24645 ENOG4105CPC Aldo Keto reductase AFR_24680 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AFR_24710 ENOG4105EMN RNA polymerase sigma factor AFR_24740 ENOG4106R7G Glycoside hydrolase family 5 AFR_24760 ENOG4105CNT hydrolase family 2 AFR_24815 ENOG4105BZU Histidine kinase AFR_24820 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AFR_24830 ENOG4105BZU Histidine kinase AFR_24835 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_24855 ENOG4107XFJ UPF0246 protein AFR_24870 ENOG4107R13 MMPL domain protein AFR_24880 ENOG4105KVH Transcriptional regulator AFR_24905 ENOG4107XWB Zinc finger, swim domain protein AFR_24910 ENOG4105C0D helicase AFR_24935 ENOG41067TZ transcriptional regulator, MarR family AFR_24945 ENOG4105CPF Cell wall formation (By similarity) AFR_24960 ENOG4105CUB amino acid AFR_24975 ENOG4107TPY serine threonine protein kinase AFR_25030 ENOG4108K2F hydrolase Family 5 AFR_25050 ENOG4107RN3 metallophosphoesterase AFR_25065 ENOG4105C0H protease AFR_25090 ENOG4105ETE Transcriptional regulator (LacI family AFR_25105 ENOG4107SM8 Adenylate Guanylate cyclase AFR_25115 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AFR_25135 ENOG4105QE3 oxidoreductase AFR_25150 ENOG4105F95 Monooxygenase AFR_25160 ENOG4105DFH Transport of potassium into the cell (By similarity) AFR_25185 ENOG4105CSU acyl-Coa dehydrogenase AFR_25205 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) AFR_25255 ENOG4105DEI Mannitol dehydrogenase AFR_25260 ENOG4105DIA mandelate racemase muconate lactonizing AFR_25265 ENOG4105D2H Uronic isomerase AFR_25270 ENOG4105DDC Oxidoreductase domain protein AFR_25275 ENOG41060NJ transcriptional regulator AFR_25285 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AFR_25290 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AFR_25355 ENOG4105CV8 reductase AFR_25360 ENOG4105D7V transposase AFR_25415 ENOG410848D S4 domain protein YaaA AFR_25440 ENOG4105WN5 stage II sporulation protein AFR_25450 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AFR_25465 ENOG4105C2J ABC transporter AFR_25470 ENOG4107RNG ABC transporter AFR_25485 ENOG4106F60 Histidine kinase AFR_25495 ENOG4105ETX regulatoR AFR_25500 ENOG4105DKQ ROK family AFR_25525 ENOG4107RNG ABC transporter AFR_25530 ENOG4105C2J ABC transporter AFR_25535 ENOG4105DFW ABC transporter AFR_25540 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) AFR_25550 ENOG4105EF1 ribulokinase AFR_25555 ENOG4105ETE Transcriptional regulator (LacI family AFR_25580 ENOG4105EUB pirin domain protein AFR_25595 ENOG4105BZU Histidine kinase AFR_25605 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_25610 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_25615 ENOG4105DJY efflux transporter, rnd family, mfp subunit AFR_25645 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_25650 ENOG4105BZU Histidine kinase AFR_25660 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_25670 ENOG4105BZU Histidine kinase AFR_25680 ENOG4108NVR Methyl-accepting chemotaxis AFR_25685 ENOG4105CBS Chea signal transduction histidine kinase AFR_25690 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AFR_25695 ENOG4105BZU Histidine kinase AFR_25720 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_25725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_25735 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_25770 ENOG4105BZU Histidine kinase AFR_25795 ENOG4107R9S Malate synthase AFR_25800 ENOG4105DEI Mannitol dehydrogenase AFR_25805 ENOG4108E16 pectate lyase AFR_25845 ENOG4105CFG Acts as a chaperone (By similarity) AFR_25880 ENOG4105CPQ Dehydrogenase AFR_25885 ENOG4105KVH Transcriptional regulator AFR_25910 ENOG4105CSU acyl-Coa dehydrogenase AFR_25915 ENOG4105BZU Histidine kinase AFR_25940 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AFR_25970 ENOG4107QIK phosphoribosylformylglycinamidine synthase AFR_25990 ENOG4105H3G oxidoreductase AFR_26005 ENOG4105CYP glycoside hydrolase, family AFR_26010 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) AFR_26015 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_26020 ENOG4108ZGX Histidine kinase AFR_26025 ENOG4105EYF MMPL domain protein AFR_26055 ENOG4105N14 lysine exporter protein LysE YggA AFR_26075 ENOG4107T3P ABC, transporter AFR_26115 ENOG4105EQX glucarate dehydratase AFR_26130 ENOG4105E0S extracellular solute-binding protein family 1 AFR_26145 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AFR_26195 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_26200 ENOG4105ENE Histidine kinase AFR_26205 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_26215 ENOG4105CEY Amp-dependent synthetase and ligase AFR_26225 ENOG4105CT1 (ABC) transporter AFR_26235 ENOG4107Q25 Serine Threonine protein kinase AFR_26270 ENOG4107TK4 histidinol-phosphate phosphatase AFR_26285 ENOG4108J20 pectate lyase AFR_26295 ENOG4105ECQ AraC Family Transcriptional Regulator AFR_26310 ENOG4105ETE Transcriptional regulator (LacI family AFR_26320 ENOG4105CQR helicase AFR_26325 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AFR_26340 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AFR_26345 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AFR_26355 ENOG4107TMB Transcriptional regulator AFR_26390 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) AFR_26400 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AFR_26405 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) AFR_26410 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) AFR_26415 ENOG4105E5F proteasome AFR_26420 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) AFR_26450 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_26465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_26470 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_26530 ENOG4108UGV hypoxanthine phosphoribosyltransferase AFR_26545 ENOG410829K Lysine exporter protein (Lyse ygga) AFR_26565 ENOG4105C3R Methionine synthase AFR_26595 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_26620 ENOG4108ZT1 Transcriptional regulator AFR_26625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AFR_26630 ENOG4105C8N cysteinyl-tRNA synthetase AFR_26650 ENOG4105DYW oxidoreductase AFR_26655 ENOG4105CPC Aldo Keto reductase AFR_26680 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AFR_26695 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AFR_26710 ENOG4105EC2 ftsk spoIIIe AFR_26755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_26765 ENOG4105JXB ankyrin repeat-containing protein AFR_26775 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AFR_26795 ENOG4105BZU Histidine kinase AFR_26840 ENOG4105EBM Alpha Beta Hydrolase Fold protein AFR_26875 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_26880 ENOG4105BZU Histidine kinase AFR_26885 ENOG4105WBV Transcriptional regulator AFR_26915 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AFR_26930 ENOG4105CMG Carbohydrate kinase AFR_26940 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFR_26950 ENOG41082YX Transcriptional regulator, arsr family AFR_26970 ENOG4105BZU Histidine kinase AFR_26975 ENOG4105CGK Exodeoxyribonuclease III AFR_27010 ENOG4105BZU Histidine kinase AFR_27015 ENOG4105CQ7 ATP-dependent helicase AFR_27020 ENOG4105CV8 reductase AFR_27025 ENOG4105BZU Histidine kinase AFR_27030 ENOG4105BZU Histidine kinase AFR_27035 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AFR_27050 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFR_27055 ENOG4105BZU Histidine kinase AFR_27060 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AFR_27110 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AFR_27115 ENOG4108R6G acetyltransferase AFR_27135 ENOG41068WN AFR_27150 ENOG4108UAJ Transcriptional regulator AFR_27160 ENOG4105BZM domain protein AFR_27215 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_27300 ENOG41065HY 1,4-beta-cellobiosidase AFR_27345 ENOG4105C6Y Udp-glucose 6-dehydrogenase AFR_27350 ENOG4105BZU Histidine kinase AFR_27355 ENOG4105FKQ transcriptional regulator AFR_27380 ENOG4105CK5 oxidoreductase AFR_27405 ENOG4105C1G acyl-Coa dehydrogenase AFR_27410 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AFR_27435 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AFR_27440 ENOG4108Q9V regulatoR AFR_27445 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AFR_27450 ENOG4108K8U Glycerol operon regulatory protein AFR_27455 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AFR_27460 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AFR_27465 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AFR_27495 ENOG4105D17 glycoside hydrolase, family 3 domain protein AFR_27510 ENOG4107RR1 TRANSCRIPTIONal AFR_27520 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AFR_27545 ENOG4105CSW GntR family transcriptional regulator AFR_27555 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) AFR_27560 ENOG4105C26 Dehydrogenase AFR_27570 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AFR_27580 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component AFR_27630 ENOG4105DFW ABC transporter AFR_27635 ENOG4105CNN ABC, transporter AFR_27645 ENOG4105EYF MMPL domain protein AFR_27660 ENOG4105BZ1 (ABC) transporter AFR_27665 ENOG4105BZU Histidine kinase AFR_27685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_27690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_27695 ENOG4105CEP NADH dehydrogenase AFR_27725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AFR_27735 ENOG4105CG3 alpha amylase, catalytic region AFR_27765 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AFR_27780 ENOG4105C26 Dehydrogenase AFR_27795 ENOG4105EW9 transcriptional regulator AsnC family AFR_27800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AFR_27805 ENOG4105CJP fad dependent oxidoreductase AFR_27830 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AFR_27870 ENOG41068WN AFR_27875 ENOG4105E2K Glycosyl transferase (Group 1 AFR_27895 ENOG410846T CoA-transferase family III AFR_27915 ENOG4107S1E Beta-lactamase AFR_27925 ENOG4105CHR reductase AFR_27930 ENOG4108QVN serine threonine protein kinase AFR_27935 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AFR_27945 ENOG4105EM7 Selenocysteine-specific translation elongation factor AFR_27950 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AFR_27955 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) AFR_27965 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AFR_27970 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AFR_27975 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AFR_27990 ENOG4105CEY Amp-dependent synthetase and ligase AFR_28000 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein AFR_28015 ENOG4106H3A restriction AFR_28035 ENOG4105BZU Histidine kinase AFR_28120 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AFR_28180 ENOG4105KAF membrAne AFR_28205 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_28215 ENOG4105DHQ Histidine kinase AFR_28235 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_28240 ENOG4105KVH Transcriptional regulator AFR_28260 ENOG4105CYP glycoside hydrolase, family AFR_28275 ENOG4105CNG UPF0061 protein AFR_28330 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_28340 ENOG4105CQF Transcriptional regulator AFR_28365 ENOG4107E6A Cytochrome p-450 AFR_28375 ENOG4105C1G acyl-Coa dehydrogenase AFR_28385 ENOG4107QX3 carboxylase AFR_28415 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AFR_28430 ENOG4105CBG Sulfatase AFR_28485 ENOG4105CGS Alpha-glucosidase AFR_28500 ENOG4106F60 Histidine kinase AFR_28505 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_28525 ENOG4105NAE bifunctional deaminase-reductase domain protein AFR_28530 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase AFR_28570 ENOG4105DQE DNA ligase AFR_28575 ENOG4105W1N transcriptional regulator AFR_28580 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AFR_28595 ENOG4107RBB ABC transporter, permease AFR_28600 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_28610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_28615 ENOG4105EB3 Histidine kinase AFR_28620 ENOG4106F60 Histidine kinase AFR_28625 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_28635 ENOG4105CKK Glycosyl transferase, family 2 AFR_28670 ENOG4108JNI Alpha beta hydrolase AFR_28695 ENOG4107RN3 metallophosphoesterase AFR_28710 ENOG4107RN3 metallophosphoesterase AFR_28760 ENOG4107QNK )-transporter AFR_28770 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_28775 ENOG4105BZU Histidine kinase AFR_28800 ENOG4108Q9V regulatoR AFR_28825 ENOG4105BZU Histidine kinase AFR_28830 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_28870 ENOG4105CJ1 ABC, transporter AFR_28890 ENOG4105ENX hydrolase AFR_28905 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AFR_28910 ENOG4108IND Tetr family transcriptional regulator AFR_28920 ENOG4108Q9V regulatoR AFR_28955 ENOG4105BZU Histidine kinase AFR_28975 ENOG4105EBM Alpha Beta Hydrolase Fold protein AFR_29005 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AFR_29080 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AFR_29085 ENOG4107EJG GntR family transcriptional regulator AFR_29105 ENOG4105DIA mandelate racemase muconate lactonizing AFR_29110 ENOG4105DRS transport system, permease AFR_29125 ENOG4105CPQ Dehydrogenase AFR_29130 ENOG4105CHR reductase AFR_29135 ENOG4105KVH Transcriptional regulator AFR_29140 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AFR_29165 ENOG4105EX0 alpha-galactosidase AFR_29185 ENOG4107SYN Glycosyl hydrolases family 43 AFR_29220 ENOG4105BZ1 (ABC) transporter AFR_29235 ENOG4105CEY Amp-dependent synthetase and ligase AFR_29240 ENOG4108RQ5 Beta-lactamase domain-containing protein AFR_29265 ENOG4107RSM transcriptional regulator AFR_29275 ENOG4105E1F short-chain dehydrogenase reductase AFR_29285 ENOG4105C9Q fumarate hydratase class II AFR_29295 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFR_29320 ENOG4105ID8 Transcriptional regulator, ARAC family AFR_29370 ENOG4107SCK Monooxygenase AFR_29375 ENOG4105D7V transposase AFR_29395 ENOG4105CHR reductase AFR_29405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_29410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_29420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_29425 ENOG4105BZU Histidine kinase AFR_29475 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AFR_29480 ENOG4105EUB pirin domain protein AFR_29500 ENOG4107SFI Major Facilitator superfamily AFR_29575 ENOG4107QRT dEAD DEAH box helicase AFR_29620 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AFR_29625 ENOG4105CAT Cytidine monophosphate kinase AFR_29635 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AFR_29640 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AFR_29650 ENOG4107VXZ Hydrolase AFR_29675 ENOG4105CM2 brancheD-chain amino acid aminotransferase AFR_29680 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AFR_29720 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AFR_29740 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AFR_29790 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AFR_29885 ENOG4105DEN Luciferase family AFR_29890 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AFR_29895 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AFR_29905 ENOG4105JNK Glycosyl transferase (Group 1 AFR_29935 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AFR_29940 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AFR_29965 ENOG4105CJ1 ABC, transporter AFR_29975 ENOG4105BZU Histidine kinase AFR_29980 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_29985 ENOG4105DSU hydrolase AFR_30000 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AFR_30015 ENOG4105CSR polyphosphate kinase 2 AFR_30020 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AFR_30055 ENOG4108VX5 3-methyladenine DNA glycosylase AFR_30070 ENOG4105CWX Alpha-1,2-mannosidase AFR_30080 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AFR_30085 ENOG4105CVJ phosphoglycerate mutase AFR_30105 ENOG4105DRS transport system, permease AFR_30115 ENOG4105NCW Trka-c domain protein AFR_30120 ENOG4105BZU Histidine kinase AFR_30125 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_30130 ENOG4105D65 subunit l AFR_30135 ENOG4105MKQ Monovalent cation H antiporter subunit C AFR_30140 ENOG4108JPZ Monovalent cation H antiporter subunit D AFR_30150 ENOG410684G monovalent cation H antiporter subunit F AFR_30155 ENOG4105KJM monovalent cation h antiporter subunit g AFR_30160 ENOG4108R1E Serine threonine protein phosphatase 1 AFR_30185 ENOG4108KB2 LysR family Transcriptional regulator AFR_30190 ENOG4107TSN permease AFR_30200 ENOG4108Q9H CobQ/CobB/MinD/ParA nucleotide binding domain AFR_30205 ENOG4105CH7 arginosuccinase AFR_30210 ENOG4105CDH Citrulline--aspartate ligase AFR_30220 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AFR_30225 ENOG4105DBV ornithine carbamoyltransferase AFR_30230 ENOG4105C8Y Acetylornithine aminotransferase AFR_30235 ENOG4105CAS nag kinase AFR_30240 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AFR_30245 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AFR_30305 ENOG4105DA5 (ABC) transporter AFR_30310 ENOG4105BZU Histidine kinase AFR_30315 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_30325 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AFR_30355 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_30385 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AFR_30390 ENOG4105DA5 (ABC) transporter AFR_30415 ENOG4108D32 Methyltransferase AFR_30430 ENOG4105CHR reductase AFR_30440 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AFR_30445 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AFR_30450 ENOG4108RWN rrna methyltransferase AFR_30455 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AFR_30460 ENOG41084BS 50S ribosomal protein L35 AFR_30465 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AFR_30475 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AFR_30480 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase AFR_30485 ENOG4105EAB amino acid AbC transporter AFR_30490 ENOG4105EAD ABC transporter AFR_30505 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AFR_30510 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AFR_30525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_30550 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AFR_30555 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AFR_30575 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AFR_30585 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AFR_30590 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AFR_30595 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AFR_30600 ENOG4105SKN orotidine 5''-phosphate decarboxylase AFR_30605 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AFR_30610 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AFR_30615 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AFR_30620 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AFR_30625 ENOG4105CD3 dihydroorotase AFR_30630 ENOG4105CXT aspartate transcarbamylase AFR_30635 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AFR_30645 ENOG410803B Involved in the transcription termination process (By similarity) AFR_30650 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AFR_30655 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AFR_30660 ENOG4105D49 3-dehydroquinate synthase AFR_30680 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AFR_30685 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AFR_30690 ENOG4105C2C drug resistance transporter, Bcr CflA AFR_30695 ENOG4105E2X shikimate dehydrogenase AFR_30700 ENOG4105HHA aminodeoxychorismate lyase AFR_30705 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AFR_30710 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AFR_30775 ENOG4106F60 Histidine kinase AFR_30780 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_30805 ENOG4105C9M aspartyl-trna synthetase AFR_30860 ENOG4105E2D ec 3.2.1.52 AFR_30870 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AFR_30890 ENOG41069H0 dihydroorotase EC 3.5.2.3 AFR_30895 ENOG4105KME endoribonuclease L-psp AFR_30905 ENOG4108YZ9 Urea amidohydrolase subunit gamma AFR_30910 ENOG4105KI2 Urea amidohydrolase subunit beta AFR_30915 ENOG4105CQM Urea amidohydrolase subunit alpha AFR_30925 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AFR_30930 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AFR_30935 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFR_30945 ENOG4107TPY serine threonine protein kinase AFR_30950 ENOG4107RRY Cyanophycin synthetase AFR_30960 ENOG4107SFI Major Facilitator superfamily AFR_30975 ENOG4108IV0 ABC, transporter AFR_30980 ENOG4105C0Z ABC transporter AFR_30995 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AFR_31005 ENOG4105EMU Dehydrogenase AFR_31015 ENOG4105CUT histidyl-tRNA synthetase AFR_31030 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) AFR_31035 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AFR_31040 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AFR_31055 ENOG4105VIE preprotein translocase, subunit YajC AFR_31060 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AFR_31065 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AFR_31070 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AFR_31080 ENOG4105CDY transcriptional regulatory protein AFR_31085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AFR_31090 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AFR_31095 ENOG4105VS8 Flagellar biosynthetic protein fliq AFR_31105 ENOG4105E2K Glycosyl transferase (Group 1 AFR_31110 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase AFR_31115 ENOG4108VTU Cdp-alcohol phosphatidyltransferase AFR_31135 ENOG4105BZU Histidine kinase AFR_31165 ENOG4105C22 threonyL-tRNA synthetase AFR_31195 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AFR_31200 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AFR_31205 ENOG4108FN7 Aldo keto reductase AFR_31215 ENOG4105VEQ Cold shock protein AFR_31255 ENOG4105D17 glycoside hydrolase, family 3 domain protein AFR_31270 ENOG4105C9U ATP-dependent DNA helicase RecQ AFR_31300 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_31305 ENOG4105BZU Histidine kinase AFR_31315 ENOG4108M15 ABC transporter AFR_31320 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_31330 ENOG4107JEE Short-chain dehydrogenase reductase Sdr AFR_31340 ENOG4107U9T Pfam:Ribonuclease_BN AFR_31385 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AFR_31435 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AFR_31450 ENOG4105EUB pirin domain protein AFR_31455 ENOG4108RYK Nad-dependent epimerase dehydratase AFR_31475 ENOG4105BZU Histidine kinase AFR_31480 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_31485 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AFR_31520 ENOG4107R9S Malate synthase AFR_31530 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AFR_31550 ENOG4105CQ7 ATP-dependent helicase AFR_31555 ENOG4105BZU Histidine kinase AFR_31575 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AFR_31610 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AFR_31615 ENOG4105K64 Glycosyl transferase, family 2 AFR_31650 ENOG4105BZU Histidine kinase AFR_31670 ENOG4105C8Q Methyl-accepting chemotaxis AFR_31695 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AFR_31700 ENOG4105BZU Histidine kinase AFR_31715 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AFR_31725 ENOG4105BZ1 (ABC) transporter AFR_31745 ENOG4105D8V Glucose sorbosone dehydrogenase AFR_31770 ENOG4105CGS Alpha-glucosidase AFR_31785 ENOG4107YBY Hydrolase AFR_31790 ENOG4105DYW oxidoreductase AFR_31795 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AFR_31800 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AFR_31825 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AFR_31840 ENOG4105DZ1 carboxypeptidase AFR_31860 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFR_31865 ENOG4105EEM helicase AFR_31875 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AFR_31880 ENOG4105C1J atp-dependent rna helicase AFR_31895 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_31930 ENOG4105ETE Transcriptional regulator (LacI family AFR_31935 ENOG4108J59 Extracellular solute-binding protein, family 5 AFR_31950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFR_31955 ENOG4105C3U ABC transporter AFR_31965 ENOG4105DAG ROK family AFR_31980 ENOG4105BZU Histidine kinase AFR_31990 ENOG4107S5I aldo keto reductase AFR_32025 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFR_32030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AFR_32050 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_32065 ENOG4105EB3 Histidine kinase AFR_32070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_32075 ENOG4105CHP RNA polymerase AFR_32080 ENOG4105GRZ Ycii-related protein AFR_32105 ENOG4105EGE secreted protein AFR_32120 ENOG4105ETE Transcriptional regulator (LacI family AFR_32155 ENOG4108JQ1 Dehydrogenase AFR_32170 ENOG4105CHF Glutathione S-transferase AFR_32180 ENOG4108ZT1 Transcriptional regulator AFR_32185 ENOG4108KTG Membrane protein, drug metabolite transporter AFR_32210 ENOG4105KKX ATPase associated with various cellular activities aaa_5 AFR_32225 ENOG4105DEG Vwa containing coxe family protein AFR_32230 ENOG4105C4K Nad synthetase AFR_32250 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AFR_32275 ENOG4105E0A ABC, transporter AFR_32280 ENOG4105TVJ transport system, permease AFR_32285 ENOG4105DQ5 transport system permease protein AFR_32330 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AFR_32355 ENOG4105D3P Mannan endo-1,4-beta-mannosidase AFR_32375 ENOG4105NAF rna polymerase sigma factor AFR_32390 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding AFR_32410 ENOG4105PDP Short chain dehydrogenase AFR_32430 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AFR_32440 ENOG4108UGD Serine Threonine protein kinase AFR_32485 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AFR_32490 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_32500 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_32515 ENOG4105D7N magnesium and cobalt transport protein CorA AFR_32545 ENOG4107QVM von Willebrand factor, type A AFR_32560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_32565 ENOG4105C0H protease AFR_32570 ENOG4105CEY Amp-dependent synthetase and ligase AFR_32575 ENOG4107R4C succinyl-diaminopimelate desuccinylase AFR_32615 ENOG4105KF0 sporulation and cell division protein, SsgA AFR_32645 ENOG4105BZU Histidine kinase AFR_32655 ENOG4105YVM Phosphoesterase, PA-phosphatase related AFR_32715 ENOG4106A3M Cytochrome p-450 AFR_32720 ENOG4106NMR serine protease AFR_32730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_32735 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AFR_32750 ENOG4105E2Y ABC, transporter AFR_32760 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AFR_32765 ENOG4105C1G acyl-Coa dehydrogenase AFR_32770 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AFR_32780 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AFR_32785 ENOG4108UZX fmn reductase AFR_32815 ENOG4108638 50S ribosomal protein L36 AFR_32825 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_32875 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AFR_32880 ENOG4105K6H D-cysteine desulfhydrase AFR_32895 ENOG4105CHR reductase AFR_32910 ENOG4108UHU Aldolase AFR_32930 ENOG4105BZU Histidine kinase AFR_32975 ENOG4105KAV tspo and mbr like protein AFR_33005 ENOG4105CG3 alpha amylase, catalytic region AFR_33015 ENOG4105E2K Glycosyl transferase (Group 1 AFR_33030 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_33035 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AFR_33040 ENOG4105BZU Histidine kinase AFR_33050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AFR_33055 ENOG4105BZU Histidine kinase AFR_33060 ENOG4105BZU Histidine kinase AFR_33065 ENOG4105D9R oxidoreductase AFR_33085 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AFR_33090 ENOG4105K5B UPF0225 protein AFR_33095 ENOG4105VUF Transcriptional regulator AFR_33105 ENOG4108NVR Methyl-accepting chemotaxis AFR_33125 ENOG4105BZ7 extracellular solute-binding protein family 1 AFR_33135 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AFR_33140 ENOG4105CG3 alpha amylase, catalytic region AFR_33155 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_33160 ENOG4108ZGX Histidine kinase AFR_33170 ENOG4105CHH sulfate transporter AFR_33180 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AFR_33185 ENOG4105C0I Conserved Protein AFR_33190 ENOG4105CAQ asparagine synthetase AFR_33220 ENOG4105BZU Histidine kinase AFR_33235 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AFR_33245 ENOG4105VEQ Cold shock protein AFR_33250 ENOG4106T9R serine protease AFR_33260 ENOG4105C2C drug resistance transporter, Bcr CflA AFR_33270 ENOG4105Q26 Siderophore-interacting protein AFR_33285 ENOG4105F4R Transcriptional regulator mode AFR_33330 ENOG4105BZU Histidine kinase AFR_33335 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_33345 ENOG4105D9U N-acetyltransferase AFR_33365 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AFR_33390 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_33400 ENOG4105MHT Transcriptional regulator, ARSR family AFR_33470 ENOG4105D3Q Sugar transferase AFR_33510 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_33515 ENOG4105BZU Histidine kinase AFR_33540 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AFR_33550 ENOG4107STQ Multicopper oxidase AFR_33565 ENOG4105DYW oxidoreductase AFR_33570 ENOG4105CIR epoxide hydrolase AFR_33580 ENOG4105KZX Pterin carbinolamine dehydratase AFR_33640 ENOG4105ETE Transcriptional regulator (LacI family AFR_33650 ENOG4105DQE DNA ligase AFR_33665 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_33675 ENOG4105CWX Alpha-1,2-mannosidase AFR_33680 ENOG410905P Pyridoxamine 5-phosphate AFR_33700 ENOG4105BZU Histidine kinase AFR_33740 ENOG4105CD8 aminopeptidase N AFR_33770 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AFR_33775 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AFR_33805 ENOG4105ETE Transcriptional regulator (LacI family AFR_33850 ENOG4105DE4 1-phosphofructokinase AFR_33860 ENOG41061GT Aldolase AFR_33870 ENOG4105CNN ABC, transporter AFR_33875 ENOG4105C2J ABC transporter AFR_33890 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_33900 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) AFR_33930 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AFR_33940 ENOG4105ENE Histidine kinase AFR_33945 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AFR_33950 ENOG41072TH Protein of unknown function (DUF1479) AFR_33975 ENOG4105CTK cobaltochelatase, cobn subunit AFR_33980 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AFR_33985 ENOG41081F0 Precorrin-8x methylmutase AFR_34005 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase AFR_34010 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein AFR_34030 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFR_34045 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_34055 ENOG4105EYF MMPL domain protein AFR_34065 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AFR_34115 ENOG4105ETX regulatoR AFR_34120 ENOG41062D9 Histidine kinase AFR_34130 ENOG4105KVH Transcriptional regulator AFR_34145 ENOG4105ECQ AraC Family Transcriptional Regulator AFR_34155 ENOG4105BZU Histidine kinase AFR_34175 ENOG4105CJQ hydrolase, family 31 AFR_34180 ENOG4108M15 ABC transporter AFR_34195 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_34210 ENOG4105BZU Histidine kinase AFR_34215 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_34250 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AFR_34255 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AFR_34260 ENOG4105C8N cysteinyl-tRNA synthetase AFR_34300 ENOG4108762 serine threonine protein kinase AFR_34345 ENOG4105DRR Transcriptional regulator, GntR family AFR_34375 ENOG41061H0 Monooxygenase AFR_34385 ENOG4108U3T pfkb domain protein AFR_34400 ENOG4105CF7 AraC family transcriptional regulator AFR_34405 ENOG4105CPC Aldo Keto reductase AFR_34415 ENOG4105K63 Thioredoxin AFR_34430 ENOG4105BZU Histidine kinase AFR_34445 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_34450 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_34540 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AFR_34580 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AFR_34620 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_34635 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AFR_34650 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AFR_34655 ENOG4108MWI inositol mono-phosphatase AFR_34660 ENOG4105YVM Phosphoesterase, PA-phosphatase related AFR_34690 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AFR_34700 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AFR_34705 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AFR_34715 ENOG4108SU4 UPF0309 protein AFR_34720 ENOG4106KNT transcriptional regulator AFR_34735 ENOG4105CEY Amp-dependent synthetase and ligase AFR_34755 ENOG4105CPQ Dehydrogenase AFR_34770 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AFR_34780 ENOG4108W6C Dehydrogenase AFR_34790 ENOG4105C7W Xanthine dehydrogenase AFR_34795 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding AFR_34800 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AFR_34815 ENOG4105BZU Histidine kinase AFR_34820 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AFR_34825 ENOG4105C5A transporter AFR_34830 ENOG4105E7W lamb ycsf family protein AFR_34835 ENOG4105CFM UPF0317 protein AFR_34840 ENOG4105P4J Allophanate hydrolase, subunit 1 AFR_34850 ENOG4105FDP GntR family transcriptional regulator AFR_34915 ENOG4105EYH Exonuclease AFR_34920 ENOG4107RH8 nuclease SbcCD subunit D AFR_34935 ENOG4105ETE Transcriptional regulator (LacI family AFR_34955 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AFR_34960 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AFR_34965 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AFR_34970 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_34985 ENOG4105DD7 kinase (PfkB family AFR_35025 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AFR_35050 ENOG4107JEE Short-chain dehydrogenase reductase Sdr AFR_35065 ENOG4105EYW Ion transport protein AFR_35080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AFR_35085 ENOG4105BZU Histidine kinase AFR_35110 ENOG4105DQE DNA ligase AFR_35135 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AFR_35150 ENOG4105CS1 NAD(P)H quinone oxidoreductase AFR_35165 ENOG4107JTW chlorite dismutase AFR_35170 ENOG4105C1Q protoporphyrinogen oxidase AFR_35175 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AFR_35190 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AFR_35200 ENOG4105CHU acetyl-coa acetyltransferase AFR_35205 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AFR_35225 ENOG4106F60 Histidine kinase AFR_35230 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_35250 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AFR_35255 ENOG4105CK2 sodium dicarboxylate symporter AFR_35260 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AFR_35265 ENOG4105C0X amino acid AFR_35270 ENOG4107VEG TrkA-N domain protein AFR_35295 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AFR_35340 ENOG4105EN6 Membrane AFR_35350 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AFR_35365 ENOG4105BZU Histidine kinase AFR_35375 ENOG4105FDP GntR family transcriptional regulator AFR_35380 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AFR_35390 ENOG4105BZU Histidine kinase AFR_35405 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AFR_35425 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AFR_35460 ENOG4106UW1 Major Facilitator superfamily AFR_35505 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AFR_35510 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AFR_35520 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AFR_35535 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AFR_35550 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AFR_35555 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AFR_35560 ENOG4105C99 atpase involved in dna repair AFR_35565 ENOG4105C7B Threonine dehydratase AFR_35575 ENOG4105KVH Transcriptional regulator AFR_35580 ENOG4107RSM transcriptional regulator AFR_35590 ENOG4105BZU Histidine kinase AFR_35595 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AFR_35605 ENOG4105CDA abc transporter atp-binding protein AFR_35610 ENOG4107UBR Extracellular solute-binding protein family 3 AFR_35615 ENOG4108Q1T ABC transporter AFR_35620 ENOG4105DRP amino acid AbC transporter AFR_35635 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AFR_35650 ENOG4105KC9 Modulates RecA activity (By similarity) AFR_35655 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AFR_35670 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AFR_35675 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AFR_35685 ENOG4105CSW GntR family transcriptional regulator AFR_35700 ENOG4108NIW Leucine export protein LeuE AFR_35705 ENOG4108N23 SpoOM-related protein AFR_35725 ENOG4105D9P serine threonine protein kinase AFR_35740 ENOG4107QRT dEAD DEAH box helicase AFR_35755 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AFR_35780 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) AFR_35795 ENOG4105WBV Transcriptional regulator AFR_35800 ENOG4105CEV competence damage-inducible protein AFR_35810 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AFR_35820 ENOG4107QZI cell division protein FtsK AFR_35835 ENOG4106T9R serine protease AFR_35840 ENOG4105CN5 Metallo-Beta-Lactamase AFR_35845 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AFR_35855 ENOG4105T0Z Conserved Protein AFR_35870 ENOG4105DRS transport system, permease AFR_35895 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AFR_35905 ENOG4105C1V Peptidase, M16 AFR_35910 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AFR_35915 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AFR_35925 ENOG4105BZU Histidine kinase AFR_35935 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AFR_35955 ENOG4105SFS phosphoesterase RecJ domain protein AFR_35960 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AFR_35975 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AFR_35990 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) AFR_36035 ENOG4108Z86 Glutamine amidotransferase AFR_36040 ENOG4108Z86 Glutamine amidotransferase AFR_36050 ENOG4105C26 Dehydrogenase AFR_36090 ENOG4105BZU Histidine kinase AFR_36095 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_36100 ENOG4108IUX (ABC) transporter AFR_36105 ENOG4105RHA ABC transporter, permease AFR_36110 ENOG4107Z3H Transcriptional regulator, TetR family AFR_36115 ENOG4105ECB domain protein AFR_36120 ENOG4105FDK ABC transporter AFR_36130 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_36140 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AFR_36145 ENOG4105DZP Membrane-associated zinc metalloprotease AFR_36165 ENOG4107R13 MMPL domain protein AFR_36180 ENOG4107B57 rieske 2fe-2S domain-containing protein AFR_36195 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AFR_36205 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AFR_36210 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AFR_36215 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AFR_36220 ENOG4105CE9 30S ribosomal protein S2 AFR_36230 ENOG41080R2 UPF0102 protein AFR_36235 ENOG4105C0P Mg chelatase subunit ChlI AFR_36255 ENOG4105FDP GntR family transcriptional regulator AFR_36270 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AFR_36275 ENOG4107791 aminotransferase class V AFR_36290 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AFR_36295 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AFR_36310 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AFR_36315 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AFR_36320 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AFR_36325 ENOG41082KU UPF0109 protein AFR_36330 ENOG4105K5M 30s ribosomal protein S16 AFR_36345 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AFR_36380 ENOG4105C39 capsular polysaccharide phosphotransferase AFR_36385 ENOG4107QQG Dehydrogenase AFR_36390 ENOG4105EXC Acyl-transferase AFR_36405 ENOG4105K64 Glycosyl transferase, family 2 AFR_36410 ENOG4105NX3 Membrane AFR_36415 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AFR_36495 ENOG4105K4I Scp-like extracellular AFR_36515 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AFR_36525 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AFR_36530 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AFR_36535 ENOG41084BZ 50S ribosomal protein L32 AFR_36550 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AFR_36555 ENOG4106H78 methyltransferase AFR_36585 ENOG4105DP4 dak2 domain fusion protein ylov AFR_36590 ENOG4105VB9 50S ribosomal protein l28 AFR_36615 ENOG4105CPF Cell wall formation (By similarity) AFR_36630 ENOG4105CZV ABC transporter AFR_36635 ENOG4105FDP GntR family transcriptional regulator AFR_36645 ENOG4105C28 cystathionine AFR_36650 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AFR_36660 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) AFR_36670 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AFR_36690 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AFR_36720 ENOG4105ERH Fumarylacetoacetate hydrolase AFR_36725 ENOG4105VZ8 Transcriptional regulator AFR_36735 ENOG4105CJ1 ABC, transporter AFR_36755 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AFR_36760 ENOG4107AQZ Membrane AFR_36770 ENOG4106F60 Histidine kinase AFR_36775 ENOG4105F44 Two component transcriptional regulator, winged helix family AFR_36780 ENOG4105C0H protease AFR_36785 ENOG4107QVM von Willebrand factor, type A AFR_36795 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AFR_36820 ENOG4108IG5 Transcriptional regulator AFR_36835 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AFR_36855 ENOG4105CM2 brancheD-chain amino acid aminotransferase AFR_36860 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AFR_36870 ENOG4108JQ1 Dehydrogenase AFR_36885 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AFR_36890 ENOG4108ZP8 Acetolactate synthase small subunit AFR_36900 ENOG4105BZU Histidine kinase AFR_36905 ENOG4105C01 Dihydroxy-acid dehydratase AFR_36915 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AFR_36930 ENOG4105ETE Transcriptional regulator (LacI family AFR_36955 ENOG4105F9U Dehydrogenase AFR_36970 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AFR_36975 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AFR_36980 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AFR_36985 ENOG4105BZU Histidine kinase AFR_36995 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AFR_37015 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AFR_37025 ENOG4105C10 Electron transfer flavoprotein AFR_37035 ENOG4105VG5 Membrane AFR_37055 ENOG4105CFG Acts as a chaperone (By similarity) AFR_37085 ENOG4108RVA ribokinase AFR_37090 ENOG4105DKW ABC transporter AFR_37115 ENOG41067SE Tetr family transcriptional regulator AFR_37135 ENOG4105C7I Dehydrogenase AFR_37145 ENOG41066UZ arginase EC 3.5.3.1 AFR_37190 ENOG4105BZU Histidine kinase AFR_37210 ENOG4105CHU acetyl-coa acetyltransferase AFR_37260 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) AFR_37275 ENOG4105EC2 ftsk spoIIIe AFR_37295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AFR_37310 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AFR_37325 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AFR_37330 ENOG4108KGH TRANSCRIPTIONal AFR_37335 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AFR_37340 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AFR_37345 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AFR_37350 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AFR_37355 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) AFR_37360 ENOG4106DE0 ATP synthase AFR_37365 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) AFR_37380 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AFR_37385 ENOG4105CGD Nad-dependent epimerase dehydratase AFR_37390 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AFR_37395 ENOG4105KJF protein tyrosine phosphatase AFR_37405 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AFR_37410 ENOG4105BZU Histidine kinase AFR_37420 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AFR_37425 ENOG4105VFB Binds the 23S rRNA (By similarity) AFR_37455 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AFR_37475 ENOG410834F Transcriptional regulator AFR_37480 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AFR_37485 ENOG4105D6E homoserine dehydrogenase AFR_37495 ENOG4105C75 arginyL-tRNA synthetase AFR_37545 ENOG4105EMU Dehydrogenase AFR_37555 ENOG4105CEY Amp-dependent synthetase and ligase AFR_37560 ENOG4105CAY ferredoxin--nadp reductase AFR_37565 ENOG4105C84 Histidine ammonia-lyase AFR_37590 ENOG4105ETX regulatoR AFR_37595 ENOG4105US7 Histidine kinase AFR_37605 ENOG4105D9P serine threonine protein kinase AFR_37640 ENOG4108J5G 6-phosphogluconate dehydrogenase AFR_37645 ENOG4105KVH Transcriptional regulator AFR_37650 ENOG4105NTD Inherit from COG: Hydrolase AFR_37660 ENOG4105EMU Dehydrogenase AFR_37665 ENOG4107RSM transcriptional regulator AFR_37680 ENOG4105KK4 UPF0060 membrane protein AFR_37705 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_37735 ENOG4105K6V RNA polymerase AFR_37770 ENOG4105EMN RNA polymerase sigma factor AFR_37775 ENOG4106032 Glutathionylspermidine synthase AFR_37790 ENOG4105CG3 alpha amylase, catalytic region AFR_37815 ENOG4107T5V SNARE associated Golgi AFR_37820 ENOG4106UDK Cellulose-binding, family II AFR_37830 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AFR_37840 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) AFR_37860 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AFR_37870 ENOG4105CIK Amidinotransferase AFR_37875 ENOG4105C8Y Acetylornithine aminotransferase AFR_37885 ENOG410842T Pterin carbinolamine dehydratase AFR_37915 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AFR_37935 ENOG4105C0H protease AFR_37940 ENOG4105BZU Histidine kinase AFR_37945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_37960 ENOG4105CJ1 ABC, transporter AFR_37970 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AFR_37990 ENOG4105BZ1 (ABC) transporter AFR_37995 ENOG4105C6K Malic enzyme AFR_38000 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AFR_38030 ENOG4108VEQ Superoxide dismutase AFR_38040 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AFR_38045 ENOG4105FDP GntR family transcriptional regulator AFR_38055 ENOG4105CBD Diacylglycerol kinase AFR_38070 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AFR_38100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AFR_38110 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AFR_38120 ENOG4105EMN RNA polymerase sigma factor AFR_38135 ENOG4108RAV Conserved protein AFR_38140 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AFR_38145 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AFR_38150 ENOG4107TK4 histidinol-phosphate phosphatase AFR_38170 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_38195 ENOG4105BZ4 penicillin-binding protein AFR_38260 ENOG4105EYF MMPL domain protein AFR_38275 ENOG4105DDN Pentapeptide repeat-containing protein AFR_38290 ENOG4105EMU Dehydrogenase AFR_38305 ENOG4105DJZ UPF0182 protein AFR_38310 ENOG41063PX domain protein AFR_38345 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) AFR_38375 ENOG4105BZU Histidine kinase AFR_38385 ENOG4105EV8 ectoine hydroxylase AFR_38390 ENOG4105E09 nadh pyrophosphatase AFR_38410 ENOG4108UJU UPF0301 protein AFR_38435 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family AFR_38450 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AFR_38465 ENOG4105VEQ Cold shock protein AFR_38485 ENOG4105ETE Transcriptional regulator (LacI family AFR_38495 ENOG4108URH decarboxylase AFR_38500 ENOG4108URH decarboxylase AFR_38505 ENOG4107R4C succinyl-diaminopimelate desuccinylase AFR_38530 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AFR_38565 ENOG4108Z4X TRANSCRIPTIONal AFR_38575 ENOG4107S5I aldo keto reductase AFR_38585 ENOG4105EMU Dehydrogenase AFR_38590 ENOG4105MHT Transcriptional regulator, ARSR family AFR_38615 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process AFR_38620 ENOG4108V75 Glutamine amidotransferase AFR_38625 ENOG41067HS methyltransferase AFR_38655 ENOG4105E2K Glycosyl transferase (Group 1 AFR_38715 ENOG4105CV8 reductase AFR_38745 ENOG4108Z4U Ferredoxin AFR_38760 ENOG4108W5M transcriptional regulator AFR_38780 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) AFR_38795 ENOG4105BZU Histidine kinase AFR_38820 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AFR_38860 ENOG4105C0Z ABC transporter AFR_38865 ENOG4108IV0 ABC, transporter AFR_38875 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AFR_38885 ENOG4105CHR reductase AFR_38890 ENOG4105DTD Dehydrogenase AFR_38900 ENOG4105C1G acyl-Coa dehydrogenase AFR_38930 ENOG4105ENE Histidine kinase AFR_38935 ENOG4108IAJ Nad-dependent epimerase dehydratase AFR_38960 ENOG4105CKK Glycosyl transferase, family 2 AFR_38965 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AFR_38985 ENOG4105C1G acyl-Coa dehydrogenase AFR_38990 ENOG4105CEY Amp-dependent synthetase and ligase AFR_39115 ENOG4105C3G gtp-binding protein AFR_39155 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AFR_39175 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AFR_39195 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AFR_39210 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AFR_39215 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AFR_39235 ENOG4105NDT Rhomboid family AFR_39250 ENOG4108IAB Phoh family AFR_39255 ENOG4105VNY Trehalose 6-phosphate phosphatase AFR_39275 ENOG4107QZT geranylgeranyl reductase AFR_39290 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) AFR_39295 ENOG4105EMN RNA polymerase sigma factor AFR_39325 ENOG4105D8K carboxyl transferase AFR_39360 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AFR_39365 ENOG4107WR6 Maf-like protein AFR_39385 ENOG4108JIK carboxylase AFR_39455 ENOG4107RM1 amidohydrolase AFR_39460 ENOG4105D5P Methylmalonyl-coA mutase AFR_39465 ENOG4105D9P serine threonine protein kinase AFR_39470 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain AFR_39485 ENOG4107SJB teichoic acid biosynthesis AFR_39495 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AFR_39500 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AFR_39505 ENOG4105C26 Dehydrogenase AFR_39510 ENOG4105C26 Dehydrogenase AFR_39540 ENOG4105GWZ Roadblock lc7 family protein AFR_39545 ENOG4105DHQ Histidine kinase AFR_39550 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AFR_39580 ENOG4105UIB (ABC) transporter AFR_39585 ENOG4108JQ9 ABC transporter AFR_39590 ENOG4105DIH basic membrane AFR_39605 ENOG4108Q5F Tetr family transcriptional regulator AFR_39625 ENOG4105C31 Tryptophanyl-tRNA synthetase AFR_39635 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AFR_39645 ENOG4105MHT Transcriptional regulator, ARSR family AFR_39660 ENOG4106Z5D Glycoside Hydrolase Family 43 AFR_39665 ENOG4105DRS transport system, permease AFR_39675 ENOG4108JE9 extracellular solute-binding protein family 1 AFR_39685 ENOG4105ETE Transcriptional regulator (LacI family AFR_39700 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo AFR_39705 ENOG4105D3Q Sugar transferase AFR_39710 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AFR_39715 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AFR_39725 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AFR_39750 ENOG4108J2P Alpha beta hydrolase fold AFR_39755 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AFR_39770 ENOG41067SE Tetr family transcriptional regulator AFR_39785 ENOG4105C5H ABC transporter AFR_39790 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AFR_39800 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AFR_39810 ENOG4105F8V Hydrolase, tatD family AFR_39825 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AFR_39850 ENOG4108ZJ4 polysaccharide deacetylase AFR_39865 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AFR_39895 ENOG4105CVM Molybdenum cofactor synthesis domain protein AFR_39900 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AFR_39905 ENOG4105BZU Histidine kinase AFR_39910 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase AFR_39960 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AFR_39965 ENOG4105DB7 PHP domain protein AFR_39990 ENOG41080RH Thioredoxin AFR_40010 ENOG4105CHR reductase AFR_40040 ENOG4105JAB phenazine biosynthesis protein, phzf family AFR_40045 ENOG4105CJW magnesium transporter AFR_40060 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AFR_40065 ENOG4105C0H protease AFR_40075 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AFR_40090 ENOG4108UKI Enoyl-CoA hydratase AFR_40105 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AFR_40120 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AFR_40125 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AFR_40130 ENOG4105DQU oxidoreductase, subunit beta AFR_40135 ENOG4107PBV potassium channel AFR_40165 ENOG4105D52 delta-aminolevulinic acid dehydratase AFR_40170 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AFR_40175 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AFR_40180 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AFR_40185 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AFR_40200 ENOG4105CEY Amp-dependent synthetase and ligase AFR_40230 ENOG41062BK proline dehydrogenase AFR_40240 ENOG4105EY0 Xylose isomerase domain protein TIM barrel AFR_40285 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AFR_40295 ENOG4108V3W Chemotaxis protein, CheW AFR_40300 ENOG4107SDU Methyl-accepting chemotaxis AFR_40305 ENOG4107QNK )-transporter AFR_40315 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AFR_40335 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AFR_40340 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AFR_40350 ENOG41065SU Two-component system sensor kinase AFR_40370 ENOG4105E4C Lytic transglycosylase catalytic AFR_40375 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AFR_40380 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AFR_40385 ENOG4105I03 Flagellin AFR_40390 ENOG4105E1Q flagellar hook-associated protein AFR_40400 ENOG4105I03 Flagellin AFR_40410 ENOG4105MQ3 flagellar protein FliS AFR_40420 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AFR_40425 ENOG4108ZC9 flagellar basal-body rod protein flgc AFR_40430 ENOG41084Q6 flagellar hook-basal body complex protein fliE AFR_40435 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AFR_40440 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AFR_40460 ENOG4105E4C Lytic transglycosylase catalytic AFR_40470 ENOG4105W00 Flagellar hook capping protein AFR_40475 ENOG4105BZE flagellar hook protein, FlgE AFR_40485 ENOG4105E14 MotA TolQ exbB proton channel AFR_40490 ENOG4106VK6 Flagellar motor protein AFR_40500 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AFR_40505 ENOG4105DD5 Flagellar motor switch protein AFR_40515 ENOG4105CN7 Flagellar biosynthetic protein FliP AFR_40520 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AFR_40525 ENOG4105D00 flagellar biosynthetic protein flhB AFR_40530 ENOG4105D7B Flagellar biosynthesis protein flha AFR_40560 ENOG4108VYJ response regulator receiver protein AFR_40575 ENOG4105BZU Histidine kinase AFR_40580 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AFR_40590 ENOG4105YFD chemotaxis, protein AFR_40595 ENOG4105CBS Chea signal transduction histidine kinase AFR_40600 ENOG4108KXV response regulator AFR_40615 ENOG4107R4N Cell wall formation (By similarity) AFR_40630 ENOG4105ETE Transcriptional regulator (LacI family AFR_40690 ENOG4105I3K Ferric uptake regulator, Fur family AFR_40695 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AFR_40700 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands AFR_40725 ENOG4105PKJ carbohydrate binding AFR_40730 ENOG4105KHC sulfurtransferase AFR_40745 ENOG4107NHD transcriptional regulator AFR_40750 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_40760 ENOG4105DXB Major Facilitator superfamily AFR_40765 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AFR_40775 ENOG4105E2Z phosphate ABC transporter (Permease AFR_40780 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AFR_40790 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AFR_40795 ENOG4105CJ3 phosphate transporter AFR_40810 ENOG4108KPJ rna polymerase sigma factor AFR_40835 ENOG4105DTA methyltransferase AFR_40840 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) AFR_40865 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AFR_40885 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AFR_40900 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AFR_40905 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AFR_40910 ENOG4105CJ1 ABC, transporter AFR_40935 ENOG4105CJ1 ABC, transporter AFR_40980 ENOG41065SU Two-component system sensor kinase AFR_40985 ENOG4108KXV response regulator AFR_41015 ENOG4105E98 transcriptional regulator DeoR family AFR_41025 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) AFR_41030 ENOG4105CE4 GlcNAc 6-P deacetylase AFR_41085 ENOG4108IJ9 (ABC) transporter AFR_41095 ENOG4105C2N RNA methyltransferase TrmH family group 3 AFR_41100 ENOG4105C8N cysteinyl-tRNA synthetase AFR_41115 ENOG4105C9Q fumarate hydratase class II AFR_41135 ENOG4107GFK fumarate AFR_41150 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AFR_41155 ENOG4105W8D rdd domain containing protein AFR_41165 ENOG4105CIH Imidazole acetol-phosphate transaminase AFR_41170 ENOG4107R34 abc transporter permease protein AFR_41175 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AFR_41180 ENOG4105BZU Histidine kinase AFR_41185 ENOG4105WH1 Two component transcriptional regulator luxr family AFR_41230 ENOG4105E2R ROK family AFR_41245 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AFR_41250 ENOG4105F8D glycoside hydrolase family 4 AFR_41270 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AFR_41275 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AFR_41300 ENOG4105FDT acyl-CoA dehydrogenase AFR_41305 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AFR_41320 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AFR_41325 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) AFR_41335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AFR_41340 ENOG4105VUC UPF0237 protein AFR_41345 ENOG4105CEN a g-specific adenine glycosylase AFR_41355 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AFR_41365 ENOG4105CRK lysyL-tRNA synthetase AFR_41370 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AFR_41380 ENOG4108IYU L-aspartate oxidase AFR_41390 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AFR_41405 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AFR_41425 ENOG4105E90 ABC transporter AFR_41430 ENOG4105R40 Glycine betaine carnitine choline AFR_41435 ENOG4108IJ8 ABC transporter AFR_41470 ENOG4105EEI dihydropteroate synthase AFR_41500 ENOG4105E4C Lytic transglycosylase catalytic AFR_41515 ENOG4105EC2 ftsk spoIIIe AFR_41535 ENOG4105EUJ GTP cyclohydrolase i AFR_41540 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AFR_41545 ENOG4108UGV hypoxanthine phosphoribosyltransferase AFR_41550 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AFR_41565 ENOG4105F0N pyrophosphate phospho-hydrolase AFR_41575 ENOG4105EC2 ftsk spoIIIe AFR_41590 ENOG4105P8F nudix hydrolase AFR_41600 ENOG4105CSM endonuclease III AFR_41605 ENOG4105PNM synthesis protein AFR_41615 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AFR_41630 ENOG4105F8J Adenylate Guanylate cyclase AFR_41635 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AFR_41670 ENOG4108JQC penicillin-binding protein 1A AFR_41675 ENOG4105KTH gatB Yqey AFR_41705 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AFR_41715 ENOG4105BZU Histidine kinase AFR_41745 ENOG4105CFH Aspartokinase AFR_41755 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AFR_41770 ENOG4105E2D ec 3.2.1.52 AFR_41775 ENOG4108JQ7 (ABC) transporter AFR_41780 ENOG4105C3U ABC transporter AFR_41790 ENOG4107QRA Extracellular solute-binding protein, family 5 AFR_41795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AFR_41800 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AFR_41805 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AFR_41860 ENOG4107R5R arsenical pump membrane protein AFR_41880 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AFR_41885 ENOG4108Z6B deaminase AFR_41915 ENOG4105EVN Prephenate dehydrogenase AFR_41925 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AFR_41930 ENOG4105DCG PHP domain protein AFR_41945 ENOG4105DHQ Histidine kinase AFR_42035 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AFR_42050 ENOG4105BZU Histidine kinase AFR_42095 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AFR_42110 ENOG4105C8V SAICAR synthetase AFR_42125 ENOG4105CGH 5'-nucleotidase AFR_42155 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AFR_42190 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AFR_42210 ENOG4108V1U phospholipid-binding protein AFR_42215 ENOG4105BZU Histidine kinase AFR_42230 ENOG41068JE domain protein AFR_42240 ENOG4105CHP RNA polymerase AFR_42265 ENOG4108Z4X TRANSCRIPTIONal AFR_42305 ENOG4106UDK Cellulose-binding, family II AFR_42330 ENOG4108Z4X TRANSCRIPTIONal AFR_42345 ENOG4108KQ5 Integrase catalytic subunit AFR_42355 ENOG4105CHU acetyl-coa acetyltransferase AFR_42370 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) AFR_42385 ENOG4105D7N magnesium and cobalt transport protein CorA AFR_42390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFR_42400 ENOG4108MDK Dehydrogenase AFR_42415 ENOG4105E2K Glycosyl transferase (Group 1 AFR_42425 ENOG4105D3Q Sugar transferase AFR_42430 ENOG4108HRK Histidine kinase AFR_42440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AFR_42445 ENOG4105EB3 Histidine kinase AFR_42465 ENOG4106SPC secreted protein AFR_42480 ENOG4105C31 Tryptophanyl-tRNA synthetase AFR_42495 ENOG4107QN1 sodium solute AFR_42510 ENOG4108KGH TRANSCRIPTIONal AFR_42525 ENOG4105BZU Histidine kinase AFR_42540 ENOG4105CEU Arginine dihydrolase AFR_42580 ENOG4108Z9K Osmotically inducible protein AFR_42590 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AFR_42595 ENOG4105J7I hydrolase AFR_42600 ENOG4108K4B hydrolase AFR_42605 ENOG4108VC7 Protein of unknown function (DUF2587) AFR_42610 ENOG4105CIK Amidinotransferase AFR_42640 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AFR_42645 ENOG4105DGI Alkaline phosphatase AFR_42665 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AFR_42675 ENOG4107RN3 metallophosphoesterase AFR_42730 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AFR_42735 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AFR_42815 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AFR_42820 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AFR_42830 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) AFR_42860 ENOG4105BZ4 penicillin-binding protein AFR_42930 ENOG4105C3M thioredoxin reductase AFR_42935 ENOG4105K63 Thioredoxin AFR_42940 ENOG4108E1C hydrolase AFR_42950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AFR_42955 ENOG4105CPF Cell wall formation (By similarity) AFR_42970 ENOG4107QJE Chromosome Partitioning Protein AFR_42975 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AFR_42985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AFR_42990 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AFR_42995 ENOG4107MT9 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AFR_43000 ENOG41084CH 50S ribosomal protein l34