locus-tag	class	description
AFR_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFR_00010	COG0592	DNA-directed DNA polymerase activity
AFR_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFR_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFR_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AFR_00040	COG0187	DNA topoisomerase II activity
AFR_00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFR_00070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFR_00095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFR_00110	COG0442	prolyl-tRNA aminoacylation
AFR_00125	COG1595	DNA-templated transcription, initiation
AFR_00155	COG0326	Molecular chaperone. Has ATPase activity
AFR_00170	COG0439	Biotin carboxylase
AFR_00175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_00190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFR_00195	COG1960	acyl-CoA dehydrogenase activity
AFR_00205	COG1846	Transcriptional regulator
AFR_00210	COG2353	YceI-like domain
AFR_00255	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AFR_00260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFR_00265	COG1716	ATPase activity
AFR_00265	COG1716	ATPase activity
AFR_00270	COG1716	ATPase activity
AFR_00285	COG0768	penicillin binding
AFR_00290	COG0515	serine threonine protein kinase
AFR_00295	COG0515	serine threonine protein kinase
AFR_00295	COG2815	serine threonine protein kinase
AFR_00325	COG0247	lactate metabolic process
AFR_00325	COG2181	nitrate reductase activity
AFR_00385	COG0717	Belongs to the dCTP deaminase family
AFR_00415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFR_00430	COG1960	acyl-CoA dehydrogenase activity
AFR_00445	COG0702	epimerase
AFR_00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_00485	COG0022	dehydrogenase e1 component
AFR_00520	COG0443	Heat shock 70 kDa protein
AFR_00525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFR_00530	COG0484	heat shock protein binding
AFR_00535	COG0789	Transcriptional regulator
AFR_00555	COG2814	Major facilitator Superfamily
AFR_00565	COG0542	response to heat
AFR_00590	COG0640	Transcriptional regulator
AFR_00600	COG0586	Pfam SNARE associated Golgi protein
AFR_00605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFR_00615	COG1595	DNA-templated transcription, initiation
AFR_00680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFR_00685	COG0151	Belongs to the GarS family
AFR_00705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFR_00715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFR_00720	COG0047	phosphoribosylformylglycinamidine synthase activity
AFR_00725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFR_00745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFR_00750	COG0641	radical SAM
AFR_00810	COG2050	protein possibly involved in aromatic compounds catabolism
AFR_00850	COG4941	Belongs to the sigma-70 factor family
AFR_00855	COG3795	YCII-related domain
AFR_00880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AFR_00915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFR_00940	COG0277	FAD linked oxidase domain protein
AFR_00960	COG0438	transferase activity, transferring glycosyl groups
AFR_00975	COG1295	ribonuclease BN
AFR_01030	COG1309	transcriptional regulator
AFR_01035	COG4941	Belongs to the sigma-70 factor family
AFR_01045	COG3655	Transcriptional regulator
AFR_01070	COG0583	DNA-binding transcription factor activity
AFR_01080	COG0667	Aldo Keto reductase
AFR_01100	COG2205	protein histidine kinase activity
AFR_01120	COG0577	efflux transmembrane transporter activity
AFR_01120	COG1136	(ABC) transporter
AFR_01125	COG1136	(ABC) transporter
AFR_01125	COG0577	efflux transmembrane transporter activity
AFR_01135	COG0840	transmembrane signaling receptor activity
AFR_01170	COG1309	transcriptional regulator
AFR_01200	COG1970	mechanosensitive ion channel activity
AFR_01210	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_01215	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_01220	COG2172	sigma factor antagonist activity
AFR_01235	COG0745	RESPONSE REGULATOR receiver
AFR_01245	COG1136	(ABC) transporter
AFR_01265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_01265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_01270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_01275	COG0438	transferase activity, transferring glycosyl groups
AFR_01280	COG0438	transferase activity, transferring glycosyl groups
AFR_01285	COG0463	Glycosyl transferase, family 2
AFR_01295	COG0784	Response regulator, receiver
AFR_01295	COG2205	protein histidine kinase activity
AFR_01315	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_01320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFR_01325	COG0406	alpha-ribazole phosphatase activity
AFR_01330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFR_01335	COG0785	Cytochrome C biogenesis protein
AFR_01345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFR_01350	COG1132	(ABC) transporter
AFR_01355	COG1132	(ABC) transporter
AFR_01370	COG1653	transport
AFR_01380	COG0366	Alpha amylase catalytic
AFR_01400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AFR_01410	COG1595	DNA-templated transcription, initiation
AFR_01420	COG0163	prenyltransferase activity
AFR_01430	COG1522	sequence-specific DNA binding
AFR_01435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFR_01450	COG0513	Belongs to the DEAD box helicase family
AFR_01465	COG0791	NLP P60 protein
AFR_01465	COG3883	PFAM NLP P60 protein
AFR_01470	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFR_01520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_01525	COG1120	ATPase activity
AFR_01540	COG1131	(ABC) transporter
AFR_01560	COG3973	AAA domain
AFR_01570	COG2814	Major facilitator Superfamily
AFR_01575	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFR_01585	COG0463	Glycosyl transferase, family 2
AFR_01600	COG0667	Aldo Keto reductase
AFR_01610	COG4279	zinc finger
AFR_01615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFR_01630	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFR_01660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_01665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_01670	COG0649	NAD binding
AFR_01685	COG1034	ATP synthesis coupled electron transport
AFR_01690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFR_01695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_01705	COG0713	ATP synthesis coupled electron transport
AFR_01720	COG1007	ATP synthesis coupled electron transport
AFR_01760	COG1950	PFAM Membrane protein of
AFR_01770	COG4842	Belongs to the WXG100 family
AFR_01790	COG0596	Alpha beta hydrolase
AFR_01800	COG3291	Pkd domain containing protein
AFR_01800	COG4412	M6 family metalloprotease domain protein
AFR_01810	COG3291	Pkd domain containing protein
AFR_01810	COG4412	M6 family metalloprotease domain protein
AFR_01815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFR_01875	COG1205	dead DEAH box helicase
AFR_01875	COG1111	helicase
AFR_01880	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_01890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AFR_01905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFR_01905	COG1754	DNA topoisomerase type I activity
AFR_01915	COG1309	transcriptional regulator
AFR_01925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFR_01930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AFR_01955	COG1774	PSP1 C-terminal conserved region
AFR_01960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFR_01985	COG0738	Major facilitator superfamily
AFR_01990	COG3226	Transcriptional regulator
AFR_02000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_02045	COG0693	protein deglycase activity
AFR_02055	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AFR_02060	COG1793	dna ligase
AFR_02060	COG3285	dna ligase
AFR_02065	COG1793	dna ligase
AFR_02065	COG3285	dna ligase
AFR_02080	COG1061	Type III restriction enzyme res subunit
AFR_02095	COG0546	phosphoglycolate phosphatase activity
AFR_02100	COG1278	Cold shock
AFR_02105	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AFR_02110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFR_02115	COG2814	Major facilitator Superfamily
AFR_02130	COG2252	PERMEase
AFR_02135	COG1846	Transcriptional regulator
AFR_02140	COG2814	Major facilitator Superfamily
AFR_02150	COG2186	Transcriptional regulator
AFR_02155	COG2807	transmembrane transport
AFR_02190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_02195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AFR_02205	COG0259	pyridoxamine-phosphate oxidase activity
AFR_02215	COG2017	converts alpha-aldose to the beta-anomer
AFR_02230	COG1960	acyl-CoA dehydrogenase activity
AFR_02250	COG1442	glycosyl transferase family 8
AFR_02250	COG1216	Glycosyl transferase, family 2
AFR_02255	COG3842	ATPase activity
AFR_02285	COG1388	LysM domain
AFR_02285	COG1134	teichoic acid transport
AFR_02295	COG1309	transcriptional regulator
AFR_02330	COG3384	dioxygenase
AFR_02340	COG3706	GGDEF domain
AFR_02400	COG0438	transferase activity, transferring glycosyl groups
AFR_02420	COG1595	DNA-templated transcription, initiation
AFR_02435	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_02440	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_02445	COG1129	ABC transporter
AFR_02545	COG1674	ftsk spoiiie
AFR_02565	COG0464	growth
AFR_02570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFR_02575	COG3903	Transcriptional regulator
AFR_02575	COG3629	intracellular signal transduction
AFR_02580	COG3903	Transcriptional regulator
AFR_02580	COG3629	intracellular signal transduction
AFR_02590	COG2197	response regulator
AFR_02625	COG0477	Major facilitator Superfamily
AFR_02630	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_02635	COG0745	RESPONSE REGULATOR receiver
AFR_02670	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AFR_02685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFR_02690	COG1086	Polysaccharide biosynthesis protein
AFR_02720	COG0463	Glycosyl transferase, family 2
AFR_02770	COG2197	response regulator
AFR_02785	COG3237	CsbD-like
AFR_02795	COG1216	Glycosyl transferase, family 2
AFR_02805	COG2089	acid synthase
AFR_02830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFR_02835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFR_02875	COG0395	ABC-type sugar transport system, permease component
AFR_02880	COG1063	alcohol dehydrogenase
AFR_02920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFR_02925	COG2119	membrane
AFR_02960	COG2213	PTS system mannitol-specific
AFR_02965	COG2213	PTS system mannitol-specific
AFR_02975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFR_02975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_02985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_02995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFR_03065	COG2837	iron assimilation
AFR_03080	COG3537	Alpha-1,2-mannosidase
AFR_03085	COG1793	dna ligase
AFR_03085	COG3285	dna ligase
AFR_03125	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_03135	COG0667	Aldo Keto reductase
AFR_03170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_03180	COG2390	Transcriptional regulator
AFR_03190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFR_03210	COG1609	Transcriptional regulator
AFR_03255	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_03265	COG1129	ABC transporter
AFR_03275	COG3347	Dehydrogenase
AFR_03275	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_03280	COG1070	Carbohydrate kinase
AFR_03285	COG0247	lactate metabolic process
AFR_03290	COG1139	Iron-sulfur cluster binding protein
AFR_03295	COG1556	Lactate utilization protein
AFR_03315	COG1309	transcriptional regulator
AFR_03320	COG1131	(ABC) transporter
AFR_03325	COG3559	Exporter of polyketide antibiotics
AFR_03335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFR_03350	COG3795	YCII-related domain
AFR_03355	COG4941	Belongs to the sigma-70 factor family
AFR_03365	COG1082	Xylose isomerase domain protein TIM barrel
AFR_03370	COG0673	inositol 2-dehydrogenase activity
AFR_03375	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_03380	COG0501	Belongs to the peptidase M48B family
AFR_03385	COG0242	peptide deformylase activity
AFR_03395	COG2124	cytochrome p450
AFR_03415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFR_03435	COG2197	response regulator
AFR_03455	COG0840	transmembrane signaling receptor activity
AFR_03465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFR_03470	COG0009	L-threonylcarbamoyladenylate synthase
AFR_03480	COG1846	Transcriptional regulator
AFR_03495	COG0431	NADPH-dependent FMN reductase
AFR_03520	COG2197	response regulator
AFR_03560	COG0673	inositol 2-dehydrogenase activity
AFR_03570	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_03635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFR_03645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFR_03725	COG1309	transcriptional regulator
AFR_03740	COG0702	epimerase
AFR_03745	COG1132	(ABC) transporter
AFR_03780	COG2197	response regulator
AFR_03875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFR_03880	COG0402	S-adenosylhomocysteine deaminase activity
AFR_03885	COG1414	Transcriptional regulator
AFR_03925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AFR_03930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AFR_03940	COG2205	protein histidine kinase activity
AFR_03945	COG0745	RESPONSE REGULATOR receiver
AFR_03970	COG1193	negative regulation of DNA recombination
AFR_03985	COG0745	RESPONSE REGULATOR receiver
AFR_03990	COG4251	negative regulation of phosphorylation
AFR_03995	COG0784	Response regulator, receiver
AFR_04000	COG0483	inositol monophosphate 1-phosphatase activity
AFR_04010	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_04025	COG0515	serine threonine protein kinase
AFR_04025	COG2815	serine threonine protein kinase
AFR_04030	COG0569	domain protein
AFR_04035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFR_04075	COG1937	Protein conserved in bacteria
AFR_04105	COG0513	Belongs to the DEAD box helicase family
AFR_04125	COG0596	Alpha beta hydrolase
AFR_04155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFR_04160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFR_04170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AFR_04200	COG2045	Belongs to the ComB family
AFR_04210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_04225	COG1595	DNA-templated transcription, initiation
AFR_04235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFR_04250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_04255	COG0839	Belongs to the complex I subunit 6 family
AFR_04260	COG0713	ATP synthesis coupled electron transport
AFR_04270	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_04275	COG1007	ATP synthesis coupled electron transport
AFR_04280	COG0501	Belongs to the peptidase M48B family
AFR_04315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_04340	COG4941	Belongs to the sigma-70 factor family
AFR_04380	COG1666	GTP binding
AFR_04400	COG5001	Diguanylate cyclase
AFR_04400	COG3300	MHYT domain
AFR_04405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFR_04410	COG2030	dehydratase
AFR_04420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFR_04430	COG0081	regulation of translation
AFR_04460	COG0085	RNA polymerase activity
AFR_04465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFR_04480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFR_04485	COG0049	tRNA binding
AFR_04490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFR_04495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFR_04500	COG0051	transcription antitermination factor activity, RNA binding
AFR_04505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFR_04510	COG0088	Forms part of the polypeptide exit tunnel
AFR_04515	COG0089	rRNA binding
AFR_04520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFR_04525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFR_04530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFR_04535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFR_04540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFR_04545	COG0255	Belongs to the universal ribosomal protein uL29 family
AFR_04550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFR_04555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFR_04560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFR_04565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFR_04570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFR_04575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFR_04580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFR_04585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFR_04590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFR_04595	COG1841	ribosomal large subunit assembly
AFR_04600	COG0200	Binds to the 23S rRNA
AFR_04610	COG0563	adenylate kinase activity
AFR_04630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFR_04635	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFR_04640	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFR_04645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFR_04650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFR_04660	COG0203	ribosomal protein L17
AFR_04665	COG0101	tRNA pseudouridine synthase activity
AFR_04675	COG2813	Specifically methylates the guanine in position
AFR_04680	COG0488	(ABC) transporter
AFR_04690	COG0352	thiamine-phosphate diphosphorylase activity
AFR_04705	COG2022	thiamine diphosphate biosynthetic process
AFR_04710	COG0352	thiamine-phosphate diphosphorylase activity
AFR_04715	COG0351	phosphomethylpyrimidine kinase
AFR_04720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFR_04745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFR_04750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_04765	COG2018	Roadblock/LC7 domain
AFR_04785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFR_04790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFR_04795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFR_04810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFR_04825	COG0736	holo-[acyl-carrier-protein] synthase activity
AFR_04835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFR_04845	COG0802	atpase or kinase
AFR_04850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFR_04855	COG1214	PFAM Peptidase M22, glycoprotease
AFR_04855	COG0456	acetyltransferase
AFR_04865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFR_04875	COG1132	(ABC) transporter
AFR_04880	COG1132	(ABC) transporter
AFR_04890	COG4214	carbohydrate transport
AFR_04905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFR_04915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFR_04920	COG0459	protein refolding
AFR_04940	COG2197	response regulator
AFR_04955	COG0516	GMP reductase activity
AFR_04970	COG1404	Belongs to the peptidase S8 family
AFR_04980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFR_04980	COG0519	Catalyzes the synthesis of GMP from XMP
AFR_04990	COG1051	belongs to the nudix hydrolase family
AFR_05000	COG1183	phosphatidylcholine synthase activity
AFR_05005	COG0688	phosphatidylethanolamine metabolic process
AFR_05025	COG2197	response regulator
AFR_05030	COG4166	transmembrane transport
AFR_05040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_05050	COG4608	Belongs to the ABC transporter superfamily
AFR_05060	COG1605	Chorismate mutase
AFR_05065	COG0737	Belongs to the 5'-nucleotidase family
AFR_05065	COG1525	nuclease
AFR_05065	COG4085	toxin activity
AFR_05075	COG0739	heme binding
AFR_05075	COG0741	lytic transglycosylase activity
AFR_05075	COG1196	nuclear chromosome segregation
AFR_05080	COG4942	peptidase
AFR_05090	COG0045	succinate-CoA ligase (ADP-forming) activity
AFR_05115	COG0138	bifunctional purine biosynthesis protein purh
AFR_05130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFR_05135	COG3540	Alkaline phosphatase
AFR_05140	COG0538	isocitrate dehydrogenase activity
AFR_05150	COG1349	DNA-binding transcription factor activity
AFR_05165	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AFR_05210	COG0529	Catalyzes the synthesis of activated sulfate
AFR_05230	COG1131	(ABC) transporter
AFR_05245	COG0789	Transcriptional regulator
AFR_05250	COG4221	oxidoreductase activity
AFR_05255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AFR_05285	COG1024	Enoyl-CoA hydratase
AFR_05285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFR_05310	COG3177	Filamentation induced by cAMP protein fic
AFR_05325	COG0148	phosphopyruvate hydratase activity
AFR_05340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFR_05380	COG0714	Associated with various cellular activities
AFR_05395	COG1252	NADH dehydrogenase
AFR_05410	COG0183	Belongs to the thiolase family
AFR_05445	COG3706	GGDEF domain
AFR_05445	COG0745	RESPONSE REGULATOR receiver
AFR_05450	COG3025	triphosphatase activity
AFR_05450	COG5607	PFAM CHAD domain containing protein
AFR_05455	COG2326	polyphosphate kinase activity
AFR_05460	COG1234	tRNA 3'-trailer cleavage
AFR_05475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_05495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFR_05515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFR_05520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFR_05530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFR_05545	COG1331	Highly conserved protein containing a thioredoxin domain
AFR_05555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFR_05565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_05580	COG0515	serine threonine protein kinase
AFR_05580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFR_05620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFR_05645	COG0778	Nitroreductase
AFR_05645	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AFR_05660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFR_05680	COG0726	polysaccharide deacetylase
AFR_05690	COG1012	belongs to the aldehyde dehydrogenase family
AFR_05700	COG1012	belongs to the aldehyde dehydrogenase family
AFR_05710	COG1515	deoxyribonuclease V activity
AFR_05715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFR_05720	COG2835	tetraacyldisaccharide 4'-kinase activity
AFR_05735	COG1482	cell wall glycoprotein biosynthetic process
AFR_05750	COG0672	)-iron permease
AFR_05760	COG2837	iron assimilation
AFR_05765	COG0745	RESPONSE REGULATOR receiver
AFR_05770	COG5002	protein histidine kinase activity
AFR_05785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AFR_05790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_05800	COG0653	protein targeting
AFR_05810	COG1522	sequence-specific DNA binding
AFR_05830	COG1012	belongs to the aldehyde dehydrogenase family
AFR_05840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFR_05845	COG2884	Cell division ATP-binding protein ftsE
AFR_05855	COG0739	heme binding
AFR_05855	COG0741	lytic transglycosylase activity
AFR_05855	COG1196	nuclear chromosome segregation
AFR_05860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFR_05880	COG2197	response regulator
AFR_05890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AFR_05895	COG1678	Uncharacterized ACR, COG1678
AFR_05925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_05930	COG1802	Transcriptional regulator
AFR_05940	COG0789	Transcriptional regulator
AFR_05975	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AFR_05980	COG2165	general secretion pathway protein
AFR_05985	COG1459	type II secretion system
AFR_05995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFR_06030	COG0745	RESPONSE REGULATOR receiver
AFR_06035	COG5002	protein histidine kinase activity
AFR_06045	COG1846	Transcriptional regulator
AFR_06180	COG1953	Uracil, thiamine, allantoin
AFR_06195	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_06205	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFR_06225	COG5002	protein histidine kinase activity
AFR_06225	COG5001	Diguanylate cyclase
AFR_06230	COG0662	Cupin 2, conserved barrel domain protein
AFR_06230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFR_06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFR_06270	COG3285	dna ligase
AFR_06270	COG1793	dna ligase
AFR_06280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_06285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFR_06295	COG0477	Major facilitator Superfamily
AFR_06310	COG1335	isochorismatase
AFR_06315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AFR_06335	COG0667	Aldo Keto reductase
AFR_06360	COG1234	tRNA 3'-trailer cleavage
AFR_06365	COG0438	transferase activity, transferring glycosyl groups
AFR_06370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFR_06375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFR_06405	COG2986	histidine ammonia-lyase
AFR_06410	COG1228	amidohydrolase
AFR_06425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AFR_06510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFR_06635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_06640	COG1177	transmembrane transport
AFR_06645	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFR_06655	COG3842	ATPase activity
AFR_06660	COG1012	belongs to the aldehyde dehydrogenase family
AFR_06670	COG0714	Associated with various cellular activities
AFR_06690	COG1595	DNA-templated transcription, initiation
AFR_06710	COG2197	response regulator
AFR_06715	COG4585	Histidine kinase
AFR_06725	COG1136	(ABC) transporter
AFR_06750	COG1376	ErfK ybiS ycfS ynhG family protein
AFR_06770	COG3629	intracellular signal transduction
AFR_06770	COG3903	Transcriptional regulator
AFR_06770	COG3629	intracellular signal transduction
AFR_06770	COG3903	Transcriptional regulator
AFR_06780	COG0784	Response regulator, receiver
AFR_06840	COG3647	Membrane
AFR_06865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFR_06870	COG0598	Magnesium transport protein CorA
AFR_06905	COG0640	Transcriptional regulator
AFR_06950	COG2378	regulation of single-species biofilm formation
AFR_06995	COG2706	6-phosphogluconolactonase activity
AFR_07020	COG2115	Belongs to the xylose isomerase family
AFR_07025	COG1070	Carbohydrate kinase
AFR_07030	COG2814	Major facilitator Superfamily
AFR_07035	COG0366	Alpha amylase catalytic
AFR_07070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFR_07075	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_07155	COG2197	response regulator
AFR_07165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_07185	COG1846	Transcriptional regulator
AFR_07190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_07205	COG2205	protein histidine kinase activity
AFR_07210	COG0745	RESPONSE REGULATOR receiver
AFR_07225	COG1136	(ABC) transporter
AFR_07230	COG0577	efflux transmembrane transporter activity
AFR_07245	COG4941	Belongs to the sigma-70 factor family
AFR_07250	COG1595	DNA-templated transcription, initiation
AFR_07280	COG0629	single-stranded DNA binding
AFR_07285	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AFR_07290	COG1492	cobalamin metabolic process
AFR_07300	COG0501	Belongs to the peptidase M48B family
AFR_07305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFR_07325	COG1793	dna ligase
AFR_07340	COG1797	cobyrinic acid a,c-diamide synthase activity
AFR_07365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFR_07370	COG1648	precorrin-2 dehydrogenase activity
AFR_07370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFR_07380	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AFR_07425	COG0668	transmembrane transport
AFR_07455	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AFR_07470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFR_07490	COG0698	ribose 5-phosphate isomerase
AFR_07500	COG4552	Acetyltransferase involved in intracellular survival and related
AFR_07510	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_07515	COG2340	Cysteine-rich secretory protein family
AFR_07535	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFR_07540	COG0740	serine-type endopeptidase activity
AFR_07545	COG0740	serine-type endopeptidase activity
AFR_07550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFR_07560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFR_07580	COG0525	valine-tRNA ligase activity
AFR_07585	COG0285	dihydrofolate synthase activity
AFR_07610	COG0105	UTP biosynthetic process
AFR_07625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFR_07635	COG3046	protein related to deoxyribodipyrimidine photolyase
AFR_07645	COG0596	Alpha beta hydrolase
AFR_07670	COG1530	ribonuclease E activity
AFR_07680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFR_07685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFR_07690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFR_07695	COG0454	-acetyltransferase
AFR_07720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFR_07725	COG0799	negative regulation of ribosome biogenesis
AFR_07730	COG0406	alpha-ribazole phosphatase activity
AFR_07740	COG1307	EDD domain protein, DegV family
AFR_07750	COG2890	protein-(glutamine-N5) methyltransferase activity
AFR_07755	COG1596	polysaccharide export
AFR_07755	COG1555	photosystem II stabilization
AFR_07760	COG0658	competence protein
AFR_07760	COG2333	competence protein COMEC
AFR_07770	COG3537	Alpha-1,2-mannosidase
AFR_07785	COG0268	Binds directly to 16S ribosomal RNA
AFR_07805	COG0481	GTPase activity
AFR_07825	COG1024	Enoyl-CoA hydratase
AFR_07840	COG1420	regulation of RNA biosynthetic process
AFR_07845	COG0484	heat shock protein binding
AFR_07855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_07860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_07865	COG1120	ATPase activity
AFR_07880	COG1132	(ABC) transporter
AFR_07895	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFR_07905	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_07915	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AFR_07940	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_07945	COG0537	adenosine 5'-monophosphoramidase activity
AFR_07960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFR_07975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFR_07995	COG1381	Involved in DNA repair and RecF pathway recombination
AFR_08000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFR_08045	COG4172	Belongs to the ABC transporter superfamily
AFR_08050	COG4721	ABC-type cobalt transport system, permease component
AFR_08055	COG0596	Alpha beta hydrolase
AFR_08080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFR_08085	COG1121	(ABC) transporter
AFR_08090	COG3443	Belongs to the bacterial solute-binding protein 9 family
AFR_08090	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFR_08110	COG0423	glycine-tRNA ligase activity
AFR_08115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFR_08115	COG3608	succinylglutamate desuccinylase aspartoacylase
AFR_08135	COG2018	Roadblock/LC7 domain
AFR_08165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFR_08170	COG0358	DNA primase activity
AFR_08195	COG1295	ribonuclease BN
AFR_08200	COG1940	carbohydrate kinase activity
AFR_08205	COG1129	ABC transporter
AFR_08210	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_08260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_08285	COG4249	Peptidase C14 caspase catalytic subunit p20
AFR_08285	COG2319	Wd-40 repeat
AFR_08325	COG0640	Transcriptional regulator
AFR_08445	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_08455	COG1012	belongs to the aldehyde dehydrogenase family
AFR_08465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFR_08475	COG2197	response regulator
AFR_08505	COG2376	Dihydroxyacetone kinase
AFR_08510	COG0018	arginyl-trna synthetase
AFR_08535	COG0714	Associated with various cellular activities
AFR_08575	COG0515	serine threonine protein kinase
AFR_08645	COG3973	AAA domain
AFR_08670	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_08690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFR_08695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFR_08735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFR_08745	COG2814	Major facilitator Superfamily
AFR_08760	COG0840	transmembrane signaling receptor activity
AFR_08765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFR_08770	COG0432	Pfam Uncharacterised protein family UPF0047
AFR_08780	COG1131	(ABC) transporter
AFR_08810	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_08825	COG2264	protein methyltransferase activity
AFR_08865	COG2226	methyltransferase
AFR_08890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFR_08900	COG0406	alpha-ribazole phosphatase activity
AFR_08900	COG0328	RNA-DNA hybrid ribonuclease activity
AFR_08925	COG0730	response to heat
AFR_08960	COG4251	negative regulation of phosphorylation
AFR_08970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFR_08985	COG0583	DNA-binding transcription factor activity
AFR_08995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_09025	COG0557	exoribonuclease II activity
AFR_09035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFR_09040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFR_09040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFR_09045	COG0174	glutamine synthetase
AFR_09050	COG3766	membrane
AFR_09060	COG0456	acetyltransferase
AFR_09060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_09070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AFR_09120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFR_09155	COG3903	Transcriptional regulator
AFR_09155	COG3629	intracellular signal transduction
AFR_09165	COG1324	tolerance protein
AFR_09205	COG4941	Belongs to the sigma-70 factor family
AFR_09225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFR_09230	COG0017	Asparaginyl-tRNA synthetase
AFR_09240	COG0321	lipoyl(octanoyl) transferase activity
AFR_09255	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_09260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFR_09270	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFR_09275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFR_09280	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AFR_09285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFR_09295	COG1994	Peptidase M50
AFR_09300	COG0667	Aldo Keto reductase
AFR_09320	COG4555	ABC transporter
AFR_09330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AFR_09345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFR_09350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFR_09360	COG1929	Belongs to the glycerate kinase type-1 family
AFR_09380	COG0425	Belongs to the sulfur carrier protein TusA family
AFR_09390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFR_09405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFR_09425	COG2010	Cytochrome c
AFR_09435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AFR_09455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AFR_09460	COG2816	NAD+ diphosphatase activity
AFR_09465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFR_09485	COG0501	Belongs to the peptidase M48B family
AFR_09490	COG0438	transferase activity, transferring glycosyl groups
AFR_09495	COG1132	(ABC) transporter
AFR_09515	COG1131	(ABC) transporter
AFR_09535	COG2197	response regulator
AFR_09555	COG1940	carbohydrate kinase activity
AFR_09565	COG2072	flavoprotein involved in K transport
AFR_09615	COG1309	transcriptional regulator
AFR_09630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFR_09640	COG0386	Belongs to the glutathione peroxidase family
AFR_09650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AFR_09665	COG0604	alcohol dehydrogenase
AFR_09665	COG3321	synthase
AFR_09685	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AFR_09690	COG2815	serine threonine protein kinase
AFR_09690	COG0515	serine threonine protein kinase
AFR_09765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_09790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFR_09795	COG1053	succinate dehydrogenase
AFR_09820	COG1846	Transcriptional regulator
AFR_09895	COG1404	Belongs to the peptidase S8 family
AFR_09910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFR_09930	COG0714	Associated with various cellular activities
AFR_09935	COG0495	leucyl-tRNA aminoacylation
AFR_09940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFR_09955	COG3442	glutamine amidotransferase
AFR_09960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFR_09970	COG2001	Belongs to the MraZ family
AFR_09975	COG0275	rRNA processing
AFR_09985	COG0768	penicillin binding
AFR_09990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFR_10000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFR_10010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFR_10015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFR_10020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFR_10025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFR_10030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFR_10035	COG1799	cell septum assembly
AFR_10060	COG3263	regulation of cellular component size
AFR_10070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFR_10090	COG0587	DNA-directed DNA polymerase activity
AFR_10105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFR_10110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_10115	COG0131	Imidazoleglycerol-phosphate dehydratase
AFR_10125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFR_10135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFR_10145	COG0583	DNA-binding transcription factor activity
AFR_10155	COG0107	imidazoleglycerol-phosphate synthase activity
AFR_10165	COG2364	Membrane
AFR_10170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_10175	COG0726	polysaccharide deacetylase
AFR_10190	COG1595	DNA-templated transcription, initiation
AFR_10195	COG1022	Amp-dependent synthetase and ligase
AFR_10210	COG2226	methyltransferase
AFR_10215	COG2205	protein histidine kinase activity
AFR_10220	COG0745	RESPONSE REGULATOR receiver
AFR_10245	COG1132	(ABC) transporter
AFR_10250	COG1132	(ABC) transporter
AFR_10255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFR_10275	COG1131	(ABC) transporter
AFR_10285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFR_10305	COG0134	indole-3-glycerol-phosphate synthase activity
AFR_10310	COG0133	tryptophan synthase activity
AFR_10315	COG0159	tryptophan synthase activity
AFR_10320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFR_10335	COG0069	glutamate synthase activity
AFR_10335	COG0070	glutamate synthase
AFR_10335	COG0067	glutamate synthase
AFR_10415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_10420	COG0765	amino acid transport
AFR_10425	COG1126	abc transporter atp-binding protein
AFR_10450	COG2226	methyltransferase
AFR_10455	COG0539	negative regulation of cytoplasmic translation
AFR_10460	COG0237	dephospho-CoA kinase activity
AFR_10460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AFR_10480	COG2329	Antibiotic biosynthesis monooxygenase
AFR_10485	COG0861	Integral membrane protein TerC family
AFR_10500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFR_10505	COG0740	serine-type endopeptidase activity
AFR_10510	COG1335	isochorismatase
AFR_10515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFR_10525	COG1162	GTPase activity
AFR_10535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFR_10545	COG0322	excinuclease ABC activity
AFR_10550	COG1660	Displays ATPase and GTPase activities
AFR_10560	COG1481	regulation of sporulation
AFR_10565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFR_10570	COG0126	phosphoglycerate kinase activity
AFR_10575	COG0149	triose-phosphate isomerase activity
AFR_10580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFR_10590	COG0456	acetyltransferase
AFR_10600	COG1595	DNA-templated transcription, initiation
AFR_10610	COG1987	bacterial-type flagellum assembly
AFR_10615	COG0363	glucosamine-6-phosphate deaminase activity
AFR_10635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFR_10645	COG0109	protoheme IX farnesyltransferase activity
AFR_10670	COG0719	Fe-S assembly protein
AFR_10675	COG2146	nitrite reductase [NAD(P)H] activity
AFR_10680	COG0396	ATPase activity
AFR_10685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFR_10690	COG0822	iron-sulfur transferase activity
AFR_10695	COG2151	metal-sulfur cluster biosynthetic enzyme
AFR_10700	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_10705	COG1063	alcohol dehydrogenase
AFR_10710	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFR_10715	COG3386	PFAM SMP-30 Gluconolaconase
AFR_10720	COG1414	Transcriptional regulator
AFR_10725	COG0129	dihydroxy-acid dehydratase activity
AFR_10775	COG2321	neutral zinc metallopeptidase
AFR_10780	COG0488	(ABC) transporter
AFR_10790	COG1024	Enoyl-CoA hydratase
AFR_10795	COG1132	(ABC) transporter
AFR_10810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_10850	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_10875	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_10885	COG3220	belongs to the UPF0276 family
AFR_10895	COG1309	transcriptional regulator
AFR_10925	COG0745	RESPONSE REGULATOR receiver
AFR_10930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFR_10960	COG1309	transcriptional regulator
AFR_10970	COG0006	proline dipeptidase activity
AFR_11005	COG0714	Associated with various cellular activities
AFR_11015	COG2304	oxidoreductase activity
AFR_11030	COG2197	response regulator
AFR_11035	COG4585	Histidine kinase
AFR_11065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFR_11075	COG0840	transmembrane signaling receptor activity
AFR_11085	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_11150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFR_11170	COG1365	unkown
AFR_11175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFR_11190	COG1175	transmembrane transport
AFR_11205	COG1175	transmembrane transport
AFR_11220	COG2223	nitrite transmembrane transporter activity
AFR_11235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFR_11235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFR_11245	COG1960	acyl-CoA dehydrogenase activity
AFR_11265	COG2018	Roadblock/LC7 domain
AFR_11270	COG5002	protein histidine kinase activity
AFR_11275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFR_11300	COG4585	Histidine kinase
AFR_11305	COG2197	response regulator
AFR_11335	COG1846	Transcriptional regulator
AFR_11340	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_11375	COG0483	inositol monophosphate 1-phosphatase activity
AFR_11440	COG0667	Aldo Keto reductase
AFR_11445	COG2205	protein histidine kinase activity
AFR_11450	COG0745	RESPONSE REGULATOR receiver
AFR_11490	COG1609	Transcriptional regulator
AFR_11495	COG0366	Alpha amylase catalytic
AFR_11515	COG1733	regulation of RNA biosynthetic process
AFR_11520	COG0667	Aldo Keto reductase
AFR_11530	COG2353	YceI-like domain
AFR_11540	COG0577	efflux transmembrane transporter activity
AFR_11540	COG1136	(ABC) transporter
AFR_11550	COG0436	Aminotransferase
AFR_11565	COG4251	negative regulation of phosphorylation
AFR_11570	COG0745	RESPONSE REGULATOR receiver
AFR_11590	COG3903	Transcriptional regulator
AFR_11590	COG3629	intracellular signal transduction
AFR_11595	COG2208	phosphoserine phosphatase activity
AFR_11595	COG2770	Histidine kinase
AFR_11605	COG2197	response regulator
AFR_11620	COG1086	Polysaccharide biosynthesis protein
AFR_11630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFR_11640	COG3795	YCII-related domain
AFR_11655	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_11660	COG0583	DNA-binding transcription factor activity
AFR_11705	COG0489	protein tyrosine kinase activity
AFR_11705	COG3206	protein involved in exopolysaccharide biosynthesis
AFR_11715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AFR_11770	COG0671	phosphoesterase, PA-phosphatase related
AFR_11800	COG0456	acetyltransferase
AFR_11800	COG1846	Transcriptional regulator
AFR_11840	COG0514	ATP-dependent DNA helicase (RecQ)
AFR_11845	COG2076	Multidrug Resistance protein
AFR_11855	COG1672	PFAM Archaeal ATPase
AFR_11855	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AFR_11895	COG0596	Alpha beta hydrolase
AFR_11915	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_11920	COG0583	DNA-binding transcription factor activity
AFR_11940	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_11960	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_11965	COG1309	transcriptional regulator
AFR_12005	COG0596	Alpha beta hydrolase
AFR_12025	COG0840	transmembrane signaling receptor activity
AFR_12050	COG0714	Associated with various cellular activities
AFR_12185	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_12205	COG0300	oxidoreductase activity
AFR_12245	COG0667	Aldo Keto reductase
AFR_12280	COG2197	response regulator
AFR_12295	COG1073	alpha beta
AFR_12310	COG1266	CAAX protease self-immunity
AFR_12325	COG4566	intracellular signal transduction
AFR_12355	COG0596	Alpha beta hydrolase
AFR_12360	COG2197	response regulator
AFR_12380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFR_12385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFR_12395	COG1595	DNA-templated transcription, initiation
AFR_12435	COG4585	Histidine kinase
AFR_12440	COG2197	response regulator
AFR_12515	COG5002	protein histidine kinase activity
AFR_12540	COG2197	response regulator
AFR_12565	COG1131	(ABC) transporter
AFR_12570	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_12575	COG1012	belongs to the aldehyde dehydrogenase family
AFR_12615	COG0604	alcohol dehydrogenase
AFR_12615	COG3321	synthase
AFR_12615	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_12625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFR_12630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_12680	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AFR_12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_12700	COG2211	Major facilitator Superfamily
AFR_12705	COG1802	Transcriptional regulator
AFR_12710	COG0473	3-isopropylmalate dehydrogenase activity
AFR_12740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_12775	COG1091	dTDP-4-dehydrorhamnose reductase activity
AFR_12790	COG1131	(ABC) transporter
AFR_12805	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_12835	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_12850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_12895	COG0300	oxidoreductase activity
AFR_12915	COG0477	Major facilitator Superfamily
AFR_12940	COG2197	response regulator
AFR_12985	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_12990	COG0667	Aldo Keto reductase
AFR_13010	COG1309	transcriptional regulator
AFR_13020	COG0702	epimerase
AFR_13030	COG0300	oxidoreductase activity
AFR_13055	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_13070	COG4211	Belongs to the binding-protein-dependent transport system permease family
AFR_13075	COG1129	ABC transporter
AFR_13085	COG0145	ligase activity
AFR_13110	COG0477	Major facilitator Superfamily
AFR_13130	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_13130	COG1024	Enoyl-CoA hydratase
AFR_13150	COG0745	RESPONSE REGULATOR receiver
AFR_13155	COG2205	protein histidine kinase activity
AFR_13170	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AFR_13195	COG1175	transmembrane transport
AFR_13255	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_13265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFR_13285	COG0667	Aldo Keto reductase
AFR_13300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_13320	COG0745	RESPONSE REGULATOR receiver
AFR_13325	COG2205	protein histidine kinase activity
AFR_13335	COG0577	efflux transmembrane transporter activity
AFR_13335	COG1136	(ABC) transporter
AFR_13340	COG4221	oxidoreductase activity
AFR_13365	COG4221	oxidoreductase activity
AFR_13370	COG0583	DNA-binding transcription factor activity
AFR_13375	COG1309	transcriptional regulator
AFR_13385	COG0477	Major facilitator Superfamily
AFR_13405	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_13445	COG2018	Roadblock/LC7 domain
AFR_13455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_13475	COG0667	Aldo Keto reductase
AFR_13480	COG0667	Aldo Keto reductase
AFR_13485	COG4221	oxidoreductase activity
AFR_13495	COG0583	DNA-binding transcription factor activity
AFR_13505	COG2814	Major facilitator Superfamily
AFR_13540	COG4221	oxidoreductase activity
AFR_13595	COG1309	transcriptional regulator
AFR_13605	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_13630	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_13655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_13665	COG1309	transcriptional regulator
AFR_13740	COG4585	Histidine kinase
AFR_13765	COG1215	transferase activity, transferring glycosyl groups
AFR_13785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_13810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFR_13820	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AFR_13870	COG2226	methyltransferase
AFR_13890	COG2264	protein methyltransferase activity
AFR_13920	COG2409	Drug exporters of the RND superfamily
AFR_13935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_13940	COG3706	GGDEF domain
AFR_13940	COG0745	RESPONSE REGULATOR receiver
AFR_13945	COG1404	Belongs to the peptidase S8 family
AFR_13950	COG1309	transcriptional regulator
AFR_13970	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_13975	COG2340	Cysteine-rich secretory protein family
AFR_13990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_14000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFR_14045	COG2837	iron assimilation
AFR_14055	COG0477	Major facilitator Superfamily
AFR_14105	COG3287	FIST C domain
AFR_14105	COG2200	EAL domain
AFR_14105	COG2199	diguanylate cyclase activity
AFR_14120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFR_14135	COG2770	Histidine kinase
AFR_14135	COG2208	phosphoserine phosphatase activity
AFR_14160	COG2860	membrane
AFR_14175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFR_14180	COG0028	Belongs to the TPP enzyme family
AFR_14200	COG0251	oxidation-reduction process
AFR_14220	COG1063	alcohol dehydrogenase
AFR_14270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFR_14275	COG2409	Drug exporters of the RND superfamily
AFR_14280	COG1063	alcohol dehydrogenase
AFR_14285	COG0701	Predicted permease
AFR_14290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFR_14300	COG1131	(ABC) transporter
AFR_14325	COG2847	Copper chaperone PCu(A)C
AFR_14335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFR_14345	COG2814	Major facilitator Superfamily
AFR_14355	COG1175	transmembrane transport
AFR_14385	COG1309	transcriptional regulator
AFR_14395	COG1309	transcriptional regulator
AFR_14535	COG1278	Cold shock
AFR_14545	COG4977	sequence-specific DNA binding
AFR_14565	COG0596	Alpha beta hydrolase
AFR_14570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFR_14580	COG4977	sequence-specific DNA binding
AFR_14580	COG1917	Cupin 2, conserved barrel domain protein
AFR_14585	COG1960	acyl-CoA dehydrogenase activity
AFR_14590	COG4608	Belongs to the ABC transporter superfamily
AFR_14610	COG0747	negative chemotaxis
AFR_14615	COG1022	Amp-dependent synthetase and ligase
AFR_14665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_14680	COG1309	transcriptional regulator
AFR_14685	COG0596	Alpha beta hydrolase
AFR_14710	COG2132	Multicopper oxidase
AFR_14725	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_14760	COG0640	Transcriptional regulator
AFR_14770	COG3693	PFAM glycoside hydrolase, family 10
AFR_14785	COG0395	ABC-type sugar transport system, permease component
AFR_14790	COG2409	Drug exporters of the RND superfamily
AFR_14805	COG4585	Histidine kinase
AFR_14810	COG2197	response regulator
AFR_14815	COG3291	Pkd domain containing protein
AFR_14825	COG1309	transcriptional regulator
AFR_14860	COG0596	Alpha beta hydrolase
AFR_14865	COG3629	intracellular signal transduction
AFR_14885	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_14895	COG4733	cellulase activity
AFR_14895	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_14900	COG3693	PFAM glycoside hydrolase, family 10
AFR_14935	COG0515	serine threonine protein kinase
AFR_14940	COG1940	carbohydrate kinase activity
AFR_14945	COG3345	alpha-galactosidase
AFR_14955	COG0395	ABC-type sugar transport system, permease component
AFR_14960	COG1175	transmembrane transport
AFR_15025	COG0596	Alpha beta hydrolase
AFR_15045	COG2205	protein histidine kinase activity
AFR_15050	COG0745	RESPONSE REGULATOR receiver
AFR_15055	COG1131	(ABC) transporter
AFR_15085	COG4941	Belongs to the sigma-70 factor family
AFR_15100	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_15105	COG0667	Aldo Keto reductase
AFR_15110	COG1064	alcohol dehydrogenase
AFR_15120	COG1733	regulation of RNA biosynthetic process
AFR_15125	COG1309	transcriptional regulator
AFR_15130	COG1131	(ABC) transporter
AFR_15145	COG0583	DNA-binding transcription factor activity
AFR_15165	COG2354	Protein conserved in bacteria
AFR_15205	COG3511	phospholipase C
AFR_15210	COG1533	DNA photolyase activity
AFR_15245	COG2207	Transcriptional regulator
AFR_15270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFR_15280	COG1733	regulation of RNA biosynthetic process
AFR_15290	COG4124	Belongs to the glycosyl hydrolase 26 family
AFR_15300	COG3833	ABC-type maltose transport systems, permease component
AFR_15305	COG1175	transmembrane transport
AFR_15315	COG1609	Transcriptional regulator
AFR_15345	COG1063	alcohol dehydrogenase
AFR_15350	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFR_15355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_15370	COG2814	Major facilitator Superfamily
AFR_15415	COG1073	alpha beta
AFR_15425	COG2205	protein histidine kinase activity
AFR_15430	COG0745	RESPONSE REGULATOR receiver
AFR_15450	COG0300	oxidoreductase activity
AFR_15455	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_15490	COG3537	Alpha-1,2-mannosidase
AFR_15510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_15590	COG3507	Belongs to the glycosyl hydrolase 43 family
AFR_15600	COG3708	Transcriptional regulator
AFR_15600	COG2207	Transcriptional regulator
AFR_15645	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_15680	COG3842	ATPase activity
AFR_15685	COG1177	transmembrane transport
AFR_15700	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_15705	COG0028	Belongs to the TPP enzyme family
AFR_15710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFR_15730	COG2072	flavoprotein involved in K transport
AFR_15765	COG2814	Major facilitator Superfamily
AFR_15790	COG2226	methyltransferase
AFR_15795	COG3866	Pectate lyase
AFR_15800	COG0596	Alpha beta hydrolase
AFR_15805	COG2356	endonuclease I
AFR_15810	COG0010	Belongs to the arginase family
AFR_15840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFR_15845	COG0667	Aldo Keto reductase
AFR_15850	COG1309	transcriptional regulator
AFR_15855	COG3181	Tripartite tricarboxylate transporter family receptor
AFR_15875	COG3290	protein histidine kinase activity
AFR_15885	COG3629	intracellular signal transduction
AFR_15885	COG3903	Transcriptional regulator
AFR_15895	COG0673	inositol 2-dehydrogenase activity
AFR_15900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFR_15940	COG0019	diaminopimelate decarboxylase activity
AFR_15945	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_15970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFR_15975	COG1216	Glycosyl transferase, family 2
AFR_15995	COG0438	transferase activity, transferring glycosyl groups
AFR_16015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_16065	COG1309	transcriptional regulator
AFR_16070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFR_16120	COG1522	sequence-specific DNA binding
AFR_16135	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AFR_16145	COG2197	response regulator
AFR_16150	COG4585	Histidine kinase
AFR_16155	COG2409	Drug exporters of the RND superfamily
AFR_16165	COG0584	glycerophosphoryl diester phosphodiesterase
AFR_16180	COG0515	serine threonine protein kinase
AFR_16180	COG2815	serine threonine protein kinase
AFR_16205	COG0667	Aldo Keto reductase
AFR_16215	COG4213	ABC transporter substrate-binding protein
AFR_16225	COG4214	carbohydrate transport
AFR_16230	COG1940	carbohydrate kinase activity
AFR_16255	COG2197	response regulator
AFR_16280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFR_16295	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AFR_16300	COG0714	Associated with various cellular activities
AFR_16345	COG0768	penicillin binding
AFR_16360	COG4221	oxidoreductase activity
AFR_16370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AFR_16375	COG2376	Dihydroxyacetone kinase
AFR_16380	COG1461	Dihydroxyacetone kinase
AFR_16385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_16385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFR_16445	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_16460	COG0531	amino acid
AFR_16475	COG1309	transcriptional regulator
AFR_16505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_16520	COG1215	transferase activity, transferring glycosyl groups
AFR_16545	COG2986	histidine ammonia-lyase
AFR_16580	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_16585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFR_16585	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AFR_16590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AFR_16595	COG0297	glycogen (starch) synthase activity
AFR_16605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AFR_16615	COG2192	nodulation
AFR_16620	COG1012	belongs to the aldehyde dehydrogenase family
AFR_16640	COG0563	adenylate kinase activity
AFR_16645	COG1120	ATPase activity
AFR_16670	COG0372	Belongs to the citrate synthase family
AFR_16715	COG0574	Belongs to the PEP-utilizing enzyme family
AFR_16715	COG3848	Pyruvate phosphate dikinase
AFR_16725	COG0577	efflux transmembrane transporter activity
AFR_16730	COG0577	efflux transmembrane transporter activity
AFR_16730	COG1136	(ABC) transporter
AFR_16755	COG1595	DNA-templated transcription, initiation
AFR_16760	COG0584	glycerophosphoryl diester phosphodiesterase
AFR_16775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFR_16780	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_16785	COG4585	Histidine kinase
AFR_16790	COG2197	response regulator
AFR_16800	COG0534	Mate efflux family protein
AFR_16815	COG1609	Transcriptional regulator
AFR_16830	COG0673	inositol 2-dehydrogenase activity
AFR_16845	COG0395	ABC-type sugar transport system, permease component
AFR_16860	COG1904	glucuronate isomerase
AFR_16865	COG0246	Mannitol dehydrogenase
AFR_16870	COG4106	trans-aconitate 2-methyltransferase activity
AFR_16910	COG1012	belongs to the aldehyde dehydrogenase family
AFR_16925	COG0022	dehydrogenase e1 component
AFR_16930	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_16955	COG0405	Gamma-glutamyltransferase
AFR_16965	COG1404	Belongs to the peptidase S8 family
AFR_16965	COG4412	M6 family metalloprotease domain protein
AFR_16995	COG5001	Diguanylate cyclase
AFR_16995	COG3300	MHYT domain
AFR_17000	COG0156	8-amino-7-oxononanoate synthase activity
AFR_17015	COG0515	serine threonine protein kinase
AFR_17015	COG2815	serine threonine protein kinase
AFR_17040	COG1595	DNA-templated transcription, initiation
AFR_17075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_17085	COG5001	Diguanylate cyclase
AFR_17085	COG3300	MHYT domain
AFR_17090	COG0156	8-amino-7-oxononanoate synthase activity
AFR_17095	COG2814	Major facilitator Superfamily
AFR_17105	COG3345	alpha-galactosidase
AFR_17115	COG0586	Pfam SNARE associated Golgi protein
AFR_17130	COG1252	NADH dehydrogenase
AFR_17165	COG1072	(Pantothenic acid kinase))
AFR_17170	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_17190	COG4251	negative regulation of phosphorylation
AFR_17210	COG3655	Transcriptional regulator
AFR_17220	COG0431	NADPH-dependent FMN reductase
AFR_17225	COG0784	Response regulator, receiver
AFR_17290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFR_17315	COG0577	efflux transmembrane transporter activity
AFR_17320	COG0577	efflux transmembrane transporter activity
AFR_17320	COG1136	(ABC) transporter
AFR_17335	COG0745	RESPONSE REGULATOR receiver
AFR_17340	COG2205	protein histidine kinase activity
AFR_17345	COG3300	MHYT domain
AFR_17345	COG5001	Diguanylate cyclase
AFR_17355	COG0463	Glycosyl transferase, family 2
AFR_17360	COG0673	inositol 2-dehydrogenase activity
AFR_17370	COG3706	GGDEF domain
AFR_17380	COG5001	Diguanylate cyclase
AFR_17380	COG3300	MHYT domain
AFR_17530	COG0515	serine threonine protein kinase
AFR_17565	COG4677	pectinesterase activity
AFR_17570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_17575	COG1802	Transcriptional regulator
AFR_17580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFR_17595	COG1335	isochorismatase
AFR_17605	COG1940	carbohydrate kinase activity
AFR_17615	COG4209	transmembrane transport
AFR_17620	COG0395	ABC-type sugar transport system, permease component
AFR_17645	COG3693	PFAM glycoside hydrolase, family 10
AFR_17650	COG2197	response regulator
AFR_17655	COG4585	Histidine kinase
AFR_17690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFR_17700	COG3191	aminopeptidase activity
AFR_17745	COG0784	Response regulator, receiver
AFR_17750	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFR_17805	COG2072	flavoprotein involved in K transport
AFR_17840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFR_17850	COG2226	methyltransferase
AFR_17860	COG0583	DNA-binding transcription factor activity
AFR_17865	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_17875	COG3866	Pectate lyase
AFR_17905	COG0438	transferase activity, transferring glycosyl groups
AFR_17915	COG0247	lactate metabolic process
AFR_17915	COG0277	FAD linked oxidase domain protein
AFR_17920	COG1733	regulation of RNA biosynthetic process
AFR_17925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFR_17930	COG0583	DNA-binding transcription factor activity
AFR_17955	COG0438	transferase activity, transferring glycosyl groups
AFR_17960	COG0438	transferase activity, transferring glycosyl groups
AFR_17965	COG0438	transferase activity, transferring glycosyl groups
AFR_17990	COG1175	transmembrane transport
AFR_18000	COG1609	Transcriptional regulator
AFR_18035	COG3509	depolymerase
AFR_18045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFR_18050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_18065	COG0667	Aldo Keto reductase
AFR_18070	COG3226	Transcriptional regulator
AFR_18100	COG0667	Aldo Keto reductase
AFR_18120	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_18140	COG5001	Diguanylate cyclase
AFR_18140	COG3300	MHYT domain
AFR_18185	COG2936	dipeptidyl-peptidase activity
AFR_18215	COG3842	ATPase activity
AFR_18220	COG1177	transmembrane transport
AFR_18250	COG3268	Saccharopine dehydrogenase
AFR_18255	COG3706	GGDEF domain
AFR_18260	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_18280	COG1609	Transcriptional regulator
AFR_18285	COG0673	inositol 2-dehydrogenase activity
AFR_18330	COG0410	ABC transporter
AFR_18380	COG1132	(ABC) transporter
AFR_18385	COG0010	Belongs to the arginase family
AFR_18425	COG4638	Rieske (2fe-2S)
AFR_18430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_18450	COG0517	IMP dehydrogenase activity
AFR_18450	COG4175	Glycine betaine
AFR_18460	COG0586	Pfam SNARE associated Golgi protein
AFR_18485	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFR_18520	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_18525	COG1960	acyl-CoA dehydrogenase activity
AFR_18540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_18550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_18570	COG2423	ornithine cyclodeaminase activity
AFR_18575	COG2197	response regulator
AFR_18580	COG4585	Histidine kinase
AFR_18590	COG0477	Major facilitator Superfamily
AFR_18595	COG1309	transcriptional regulator
AFR_18610	COG2814	Major facilitator Superfamily
AFR_18620	COG3706	GGDEF domain
AFR_18640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFR_18650	COG3384	dioxygenase
AFR_18685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFR_18690	COG2146	nitrite reductase [NAD(P)H] activity
AFR_18695	COG2223	nitrite transmembrane transporter activity
AFR_18755	COG4335	DNA alkylation repair
AFR_18760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFR_18795	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFR_18800	COG1121	(ABC) transporter
AFR_18860	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_18910	COG3706	GGDEF domain
AFR_18910	COG0745	RESPONSE REGULATOR receiver
AFR_18925	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_18925	COG4733	cellulase activity
AFR_18935	COG1609	Transcriptional regulator
AFR_18940	COG1879	ABC-type sugar transport system periplasmic component
AFR_18950	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_18955	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_18965	COG0590	tRNA wobble adenosine to inosine editing
AFR_18970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_18980	COG0477	Major facilitator Superfamily
AFR_18990	COG2318	DinB family
AFR_18995	COG0254	rRNA binding
AFR_19005	COG3864	Putative metallopeptidase domain
AFR_19035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFR_19040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AFR_19045	COG2080	2 iron, 2 sulfur cluster binding
AFR_19080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFR_19085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFR_19120	COG5001	Diguanylate cyclase
AFR_19125	COG0275	rRNA processing
AFR_19135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_19140	COG2207	Transcriptional regulator
AFR_19145	COG0667	Aldo Keto reductase
AFR_19165	COG3300	MHYT domain
AFR_19165	COG5001	Diguanylate cyclase
AFR_19185	COG1987	bacterial-type flagellum assembly
AFR_19230	COG2205	protein histidine kinase activity
AFR_19235	COG0745	RESPONSE REGULATOR receiver
AFR_19255	COG1414	Transcriptional regulator
AFR_19260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFR_19265	COG0596	Alpha beta hydrolase
AFR_19270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFR_19275	COG3485	protocatechuate 3,4-dioxygenase
AFR_19280	COG3485	protocatechuate 3,4-dioxygenase
AFR_19285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AFR_19290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AFR_19305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_19310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_19320	COG1012	belongs to the aldehyde dehydrogenase family
AFR_19325	COG2267	carboxylic ester hydrolase activity
AFR_19395	COG1175	transmembrane transport
AFR_19400	COG3833	ABC-type maltose transport systems, permease component
AFR_19420	COG3226	Transcriptional regulator
AFR_19430	COG0748	coenzyme F420 binding
AFR_19435	COG2814	Major facilitator Superfamily
AFR_19440	COG1846	Transcriptional regulator
AFR_19445	COG0667	Aldo Keto reductase
AFR_19450	COG3104	oligopeptide transport
AFR_19455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AFR_19455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AFR_19460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFR_19470	COG0745	RESPONSE REGULATOR receiver
AFR_19475	COG2205	protein histidine kinase activity
AFR_19490	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AFR_19495	COG1691	(AIR) carboxylase
AFR_19500	COG1606	tRNA processing
AFR_19505	COG1609	Transcriptional regulator
AFR_19520	COG0183	Belongs to the thiolase family
AFR_19525	COG1122	ATPase activity
AFR_19540	COG0310	cobalt ion transport
AFR_19565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFR_19580	COG3401	FG-GAP repeat protein
AFR_19590	COG3226	Transcriptional regulator
AFR_19595	COG0247	lactate metabolic process
AFR_19600	COG0277	FAD linked oxidase domain protein
AFR_19605	COG0277	FAD linked oxidase domain protein
AFR_19620	COG1063	alcohol dehydrogenase
AFR_19660	COG4941	Belongs to the sigma-70 factor family
AFR_19665	COG0435	Glutathione S-transferase
AFR_19670	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AFR_19690	COG0514	ATP-dependent DNA helicase (RecQ)
AFR_19715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_19720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_19720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFR_19735	COG0438	transferase activity, transferring glycosyl groups
AFR_19750	COG1183	phosphatidylcholine synthase activity
AFR_19755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFR_19775	COG2233	PERMEase
AFR_19785	COG0789	Transcriptional regulator
AFR_19815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_19815	COG0543	2 iron, 2 sulfur cluster binding
AFR_19820	COG0326	Molecular chaperone. Has ATPase activity
AFR_19830	COG2130	NADP-dependent
AFR_19865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_19880	COG0477	Major facilitator Superfamily
AFR_19890	COG1309	transcriptional regulator
AFR_19910	COG0577	efflux transmembrane transporter activity
AFR_19910	COG1136	(ABC) transporter
AFR_19920	COG4585	Histidine kinase
AFR_19925	COG2201	protein-glutamate methylesterase activity
AFR_19945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_19950	COG4565	transcriptional regulatory protein
AFR_19960	COG1301	dicarboxylic acid transport
AFR_19970	COG1609	Transcriptional regulator
AFR_20000	COG0659	secondary active sulfate transmembrane transporter activity
AFR_20010	COG0477	Major facilitator Superfamily
AFR_20020	COG1595	DNA-templated transcription, initiation
AFR_20045	COG1132	(ABC) transporter
AFR_20050	COG1132	(ABC) transporter
AFR_20055	COG2814	Major facilitator Superfamily
AFR_20080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_20130	COG0515	serine threonine protein kinase
AFR_20135	COG4988	ABC transporter
AFR_20140	COG1294	oxidase, subunit
AFR_20145	COG1271	oxidase subunit
AFR_20170	COG1846	Transcriptional regulator
AFR_20175	COG0596	Alpha beta hydrolase
AFR_20180	COG5001	Diguanylate cyclase
AFR_20180	COG3447	MASE1 domain protein
AFR_20180	COG5002	protein histidine kinase activity
AFR_20185	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_20195	COG0596	Alpha beta hydrolase
AFR_20200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_20255	COG0159	tryptophan synthase activity
AFR_20260	COG0133	tryptophan synthase activity
AFR_20280	COG2197	response regulator
AFR_20285	COG4585	Histidine kinase
AFR_20290	COG0596	Alpha beta hydrolase
AFR_20315	COG0745	RESPONSE REGULATOR receiver
AFR_20335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_20355	COG0640	Transcriptional regulator
AFR_20375	COG2197	response regulator
AFR_20380	COG4585	Histidine kinase
AFR_20410	COG0693	protein deglycase activity
AFR_20410	COG0753	catalase activity
AFR_20425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFR_20430	COG2011	ABC-type metal ion transport system permease component
AFR_20435	COG1464	Belongs to the NlpA lipoprotein family
AFR_20450	COG0166	Belongs to the GPI family
AFR_20465	COG1280	lysine exporter protein (LysE YggA)
AFR_20480	COG0588	phosphoglycerate mutase activity
AFR_20490	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_20500	COG1940	carbohydrate kinase activity
AFR_20505	COG2814	Major facilitator Superfamily
AFR_20510	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_20525	COG3842	ATPase activity
AFR_20535	COG1609	Transcriptional regulator
AFR_20540	COG1609	Transcriptional regulator
AFR_20565	COG0745	RESPONSE REGULATOR receiver
AFR_20570	COG2205	protein histidine kinase activity
AFR_20580	COG1136	(ABC) transporter
AFR_20585	COG0577	efflux transmembrane transporter activity
AFR_20585	COG1136	(ABC) transporter
AFR_20630	COG3384	dioxygenase
AFR_20670	COG3226	Transcriptional regulator
AFR_20685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_20695	COG3718	enzyme involved in inositol metabolism
AFR_20700	COG3962	Belongs to the TPP enzyme family
AFR_20730	COG0673	inositol 2-dehydrogenase activity
AFR_20735	COG1082	Xylose isomerase domain protein TIM barrel
AFR_20745	COG0673	inositol 2-dehydrogenase activity
AFR_20750	COG1609	Transcriptional regulator
AFR_20760	COG1082	Xylose isomerase domain protein TIM barrel
AFR_20770	COG1609	Transcriptional regulator
AFR_20780	COG1309	transcriptional regulator
AFR_20785	COG2050	protein possibly involved in aromatic compounds catabolism
AFR_20795	COG0183	Belongs to the thiolase family
AFR_20800	COG1024	Enoyl-CoA hydratase
AFR_20805	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_20810	COG3396	Phenylacetate-CoA oxygenase
AFR_20815	COG3460	Phenylacetate-CoA oxygenase
AFR_20820	COG3396	Phenylacetate-CoA oxygenase
AFR_20825	COG2151	metal-sulfur cluster biosynthetic enzyme
AFR_20830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_20845	COG0667	Aldo Keto reductase
AFR_20855	COG2226	methyltransferase
AFR_20885	COG1595	DNA-templated transcription, initiation
AFR_20895	COG2409	Drug exporters of the RND superfamily
AFR_20905	COG2197	response regulator
AFR_20915	COG1131	(ABC) transporter
AFR_20950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFR_21020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFR_21025	COG0297	glycogen (starch) synthase activity
AFR_21035	COG1649	PFAM Uncharacterised BCR, COG1649
AFR_21040	COG0488	(ABC) transporter
AFR_21045	COG0384	phenazine biosynthesis protein PhzF
AFR_21050	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AFR_21055	COG4867	von Willebrand factor, type A
AFR_21080	COG0509	glycine decarboxylation via glycine cleavage system
AFR_21085	COG1716	ATPase activity
AFR_21105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFR_21120	COG0583	DNA-binding transcription factor activity
AFR_21130	COG1278	Cold shock
AFR_21135	COG2226	methyltransferase
AFR_21155	COG0745	RESPONSE REGULATOR receiver
AFR_21160	COG2205	protein histidine kinase activity
AFR_21190	COG0667	Aldo Keto reductase
AFR_21195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFR_21195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFR_21205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFR_21220	COG1595	DNA-templated transcription, initiation
AFR_21225	COG0242	peptide deformylase activity
AFR_21235	COG0494	nUDIX hydrolase
AFR_21240	COG0019	diaminopimelate decarboxylase activity
AFR_21265	COG1131	(ABC) transporter
AFR_21275	COG4585	Histidine kinase
AFR_21280	COG2197	response regulator
AFR_21285	COG1191	sigma factor activity
AFR_21300	COG0488	(ABC) transporter
AFR_21305	COG4974	Belongs to the 'phage' integrase family
AFR_21310	COG1968	undecaprenyl-diphosphatase activity
AFR_21360	COG2270	Major facilitator Superfamily
AFR_21385	COG2197	response regulator
AFR_21410	COG2362	D-Aminopeptidase
AFR_21415	COG0204	Acyl-transferase
AFR_21445	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_21455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_21460	COG1309	transcriptional regulator
AFR_21480	COG2267	carboxylic ester hydrolase activity
AFR_21485	COG1764	response to oxidative stress
AFR_21490	COG1846	Transcriptional regulator
AFR_21505	COG4702	Belongs to the UPF0303 family
AFR_21525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_21560	COG2197	response regulator
AFR_21575	COG4585	Histidine kinase
AFR_21580	COG2197	response regulator
AFR_21595	COG2267	carboxylic ester hydrolase activity
AFR_21600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_21635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFR_21665	COG1609	Transcriptional regulator
AFR_21680	COG0395	ABC-type sugar transport system, permease component
AFR_21695	COG2197	response regulator
AFR_21700	COG4585	Histidine kinase
AFR_21715	COG4257	antibiotic catabolic process
AFR_21720	COG1404	Belongs to the peptidase S8 family
AFR_21765	COG5002	protein histidine kinase activity
AFR_21765	COG0784	Response regulator, receiver
AFR_21765	COG2205	protein histidine kinase activity
AFR_21785	COG0463	Glycosyl transferase, family 2
AFR_21800	COG1607	acyl-coa hydrolase
AFR_21805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_21810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AFR_21820	COG0604	alcohol dehydrogenase
AFR_21825	COG1509	lysine 2,3-aminomutase activity
AFR_21830	COG3237	CsbD-like
AFR_21860	COG1960	acyl-CoA dehydrogenase activity
AFR_21865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFR_21870	COG5001	Diguanylate cyclase
AFR_21880	COG1309	transcriptional regulator
AFR_21885	COG0400	carboxylic ester hydrolase activity
AFR_21895	COG5001	Diguanylate cyclase
AFR_21925	COG2197	response regulator
AFR_21995	COG3546	catalase activity
AFR_22015	COG1914	H( )-stimulated, divalent metal cation uptake system
AFR_22020	COG0745	RESPONSE REGULATOR receiver
AFR_22095	COG2814	Major facilitator Superfamily
AFR_22140	COG4221	oxidoreductase activity
AFR_22235	COG0583	DNA-binding transcription factor activity
AFR_22250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_22255	COG1116	anion transmembrane transporter activity
AFR_22265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_22280	COG0277	FAD linked oxidase domain protein
AFR_22295	COG0251	oxidation-reduction process
AFR_22300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_22305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFR_22310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_22315	COG1116	anion transmembrane transporter activity
AFR_22320	COG4682	membrane
AFR_22335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFR_22340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_22345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_22375	COG0747	negative chemotaxis
AFR_22405	COG0531	amino acid
AFR_22415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFR_22430	COG1501	Belongs to the glycosyl hydrolase 31 family
AFR_22440	COG1175	transmembrane transport
AFR_22460	COG1609	Transcriptional regulator
AFR_22495	COG1105	Belongs to the carbohydrate kinase PfkB family
AFR_22530	COG0395	ABC-type sugar transport system, permease component
AFR_22535	COG1175	transmembrane transport
AFR_22540	COG2182	Extracellular solute-binding protein
AFR_22545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFR_22550	COG1486	melibiose metabolic process
AFR_22555	COG1349	DNA-binding transcription factor activity
AFR_22560	COG3201	nicotinamide mononucleotide transporter
AFR_22580	COG1309	transcriptional regulator
AFR_22615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_22620	COG0789	Transcriptional regulator
AFR_22695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_22725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_22735	COG0148	phosphopyruvate hydratase activity
AFR_22740	COG0789	Transcriptional regulator
AFR_22745	COG0303	'Molybdopterin
AFR_22750	COG2226	methyltransferase
AFR_22765	COG0840	transmembrane signaling receptor activity
AFR_22785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFR_22785	COG2080	2 iron, 2 sulfur cluster binding
AFR_22810	COG0745	RESPONSE REGULATOR receiver
AFR_22815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFR_22875	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFR_22880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AFR_22890	COG0667	Aldo Keto reductase
AFR_22900	COG0483	inositol monophosphate 1-phosphatase activity
AFR_22915	COG0477	Major facilitator Superfamily
AFR_22975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_22980	COG1309	transcriptional regulator
AFR_22995	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_23005	COG0702	epimerase
AFR_23010	COG1309	transcriptional regulator
AFR_23020	COG1017	nitric oxide dioxygenase activity
AFR_23020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_23040	COG4221	oxidoreductase activity
AFR_23055	COG0596	Alpha beta hydrolase
AFR_23060	COG0596	Alpha beta hydrolase
AFR_23115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_23125	COG0778	Nitroreductase
AFR_23145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFR_23185	COG2217	Heavy metal translocating P-type atpase
AFR_23195	COG1404	Belongs to the peptidase S8 family
AFR_23215	COG2197	response regulator
AFR_23235	COG2376	Dihydroxyacetone kinase
AFR_23245	COG0640	Transcriptional regulator
AFR_23265	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AFR_23305	COG1216	Glycosyl transferase, family 2
AFR_23310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFR_23315	COG0438	transferase activity, transferring glycosyl groups
AFR_23340	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_23385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AFR_23415	COG1063	alcohol dehydrogenase
AFR_23425	COG1819	glycosyl
AFR_23430	COG3973	AAA domain
AFR_23450	COG1595	DNA-templated transcription, initiation
AFR_23470	COG2205	protein histidine kinase activity
AFR_23520	COG0640	Transcriptional regulator
AFR_23535	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_23540	COG0596	Alpha beta hydrolase
AFR_23560	COG2273	Hydrolase Family 16
AFR_23580	COG2826	transposase and inactivated derivatives, IS30 family
AFR_23595	COG0726	polysaccharide deacetylase
AFR_23620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_23625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_23630	COG1120	ATPase activity
AFR_23640	COG1132	(ABC) transporter
AFR_23645	COG4106	trans-aconitate 2-methyltransferase activity
AFR_23675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_23685	COG3976	FMN-binding domain protein
AFR_23685	COG1053	succinate dehydrogenase
AFR_23685	COG0431	NADPH-dependent FMN reductase
AFR_23690	COG1917	Cupin 2, conserved barrel domain protein
AFR_23695	COG1414	Transcriptional regulator
AFR_23715	COG3384	dioxygenase
AFR_23730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFR_23745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_23755	COG3971	2-oxopent-4-enoate hydratase activity
AFR_23760	COG1414	Transcriptional regulator
AFR_23800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFR_23835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_23860	COG0300	oxidoreductase activity
AFR_23870	COG1595	DNA-templated transcription, initiation
AFR_23915	COG1595	DNA-templated transcription, initiation
AFR_23920	COG3795	YCII-related domain
AFR_23925	COG4941	Belongs to the sigma-70 factor family
AFR_23930	COG1846	Transcriptional regulator
AFR_23935	COG0697	spore germination
AFR_23950	COG0583	DNA-binding transcription factor activity
AFR_23965	COG1653	transport
AFR_23970	COG1175	transmembrane transport
AFR_23975	COG0395	ABC-type sugar transport system, permease component
AFR_23980	COG0058	SHG alpha-glucan phosphorylase activity
AFR_24000	COG2205	protein histidine kinase activity
AFR_24020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFR_24035	COG0640	Transcriptional regulator
AFR_24055	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AFR_24060	COG0745	RESPONSE REGULATOR receiver
AFR_24065	COG2205	protein histidine kinase activity
AFR_24115	COG4251	negative regulation of phosphorylation
AFR_24120	COG1620	l-lactate permease
AFR_24190	COG0366	Alpha amylase catalytic
AFR_24195	COG2197	response regulator
AFR_24205	COG1136	(ABC) transporter
AFR_24205	COG0577	efflux transmembrane transporter activity
AFR_24220	COG1309	transcriptional regulator
AFR_24240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_24245	COG0747	negative chemotaxis
AFR_24290	COG2770	Histidine kinase
AFR_24290	COG2208	phosphoserine phosphatase activity
AFR_24305	COG2890	protein-(glutamine-N5) methyltransferase activity
AFR_24310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_24335	COG1309	transcriptional regulator
AFR_24340	COG0300	oxidoreductase activity
AFR_24385	COG3842	ATPase activity
AFR_24390	COG1178	ABC-type Fe3 transport system permease component
AFR_24395	COG1840	ABC-type Fe3 transport system, periplasmic component
AFR_24400	COG0745	RESPONSE REGULATOR receiver
AFR_24405	COG5002	protein histidine kinase activity
AFR_24415	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AFR_24420	COG4521	taurine ABC transporter
AFR_24425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_24435	COG3795	YCII-related domain
AFR_24440	COG4941	Belongs to the sigma-70 factor family
AFR_24445	COG2226	methyltransferase
AFR_24490	COG0477	Major facilitator Superfamily
AFR_24510	COG1609	Transcriptional regulator
AFR_24530	COG0456	acetyltransferase
AFR_24545	COG0701	Predicted permease
AFR_24600	COG2197	response regulator
AFR_24605	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AFR_24620	COG1595	DNA-templated transcription, initiation
AFR_24645	COG0667	Aldo Keto reductase
AFR_24680	COG2255	four-way junction helicase activity
AFR_24710	COG1595	DNA-templated transcription, initiation
AFR_24760	COG3250	beta-galactosidase activity
AFR_24800	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_24820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AFR_24825	COG5001	Diguanylate cyclase
AFR_24830	COG3851	Histidine kinase
AFR_24835	COG2197	response regulator
AFR_24855	COG3022	response to hydroperoxide
AFR_24870	COG2409	Drug exporters of the RND superfamily
AFR_24880	COG1733	regulation of RNA biosynthetic process
AFR_24905	COG4279	zinc finger
AFR_24910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFR_24935	COG1846	Transcriptional regulator
AFR_24940	COG0477	Major facilitator Superfamily
AFR_24945	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFR_24960	COG0531	amino acid
AFR_24975	COG0515	serine threonine protein kinase
AFR_25025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFR_25050	COG1408	metallophosphoesterase
AFR_25065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_25090	COG1609	Transcriptional regulator
AFR_25105	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AFR_25105	COG1672	PFAM Archaeal ATPase
AFR_25115	COG1619	proteins homologs of microcin C7 resistance protein MccF
AFR_25135	COG0277	FAD linked oxidase domain protein
AFR_25150	COG2072	flavoprotein involved in K transport
AFR_25160	COG3158	transport of potassium into the cell
AFR_25185	COG1960	acyl-CoA dehydrogenase activity
AFR_25205	COG3940	Belongs to the glycosyl hydrolase 43 family
AFR_25255	COG0246	Mannitol dehydrogenase
AFR_25260	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_25265	COG1904	glucuronate isomerase
AFR_25270	COG0673	inositol 2-dehydrogenase activity
AFR_25275	COG1609	Transcriptional regulator
AFR_25285	COG1175	transmembrane transport
AFR_25290	COG0395	ABC-type sugar transport system, permease component
AFR_25355	COG0656	L-ascorbic acid biosynthetic process
AFR_25400	COG0395	ABC-type sugar transport system, permease component
AFR_25415	COG2501	S4 domain
AFR_25430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFR_25440	COG1366	Belongs to the anti-sigma-factor antagonist family
AFR_25450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFR_25470	COG4214	carbohydrate transport
AFR_25485	COG2205	protein histidine kinase activity
AFR_25495	COG0745	RESPONSE REGULATOR receiver
AFR_25500	COG1940	carbohydrate kinase activity
AFR_25525	COG4214	carbohydrate transport
AFR_25530	COG1129	ABC transporter
AFR_25535	COG4213	ABC transporter substrate-binding protein
AFR_25540	COG2160	L-arabinose isomerase activity
AFR_25555	COG1609	Transcriptional regulator
AFR_25595	COG3706	GGDEF domain
AFR_25605	COG0577	efflux transmembrane transporter activity
AFR_25605	COG1136	(ABC) transporter
AFR_25610	COG0577	efflux transmembrane transporter activity
AFR_25610	COG1136	(ABC) transporter
AFR_25615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AFR_25645	COG2197	response regulator
AFR_25650	COG3850	Histidine kinase
AFR_25670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AFR_25685	COG2198	Histidine kinase
AFR_25685	COG0643	Histidine kinase
AFR_25690	COG2201	protein-glutamate methylesterase activity
AFR_25695	COG4251	negative regulation of phosphorylation
AFR_25720	COG0577	efflux transmembrane transporter activity
AFR_25720	COG1136	(ABC) transporter
AFR_25725	COG0577	efflux transmembrane transporter activity
AFR_25725	COG1136	(ABC) transporter
AFR_25735	COG2197	response regulator
AFR_25780	COG0726	polysaccharide deacetylase
AFR_25805	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_25845	COG0443	Heat shock 70 kDa protein
AFR_25880	COG1063	alcohol dehydrogenase
AFR_25885	COG1733	regulation of RNA biosynthetic process
AFR_25910	COG1960	acyl-CoA dehydrogenase activity
AFR_25925	COG3629	intracellular signal transduction
AFR_25925	COG3903	Transcriptional regulator
AFR_25940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_25950	COG3629	intracellular signal transduction
AFR_25950	COG3903	Transcriptional regulator
AFR_25965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFR_25970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFR_25990	COG2072	flavoprotein involved in K transport
AFR_26015	COG2197	response regulator
AFR_26020	COG4585	Histidine kinase
AFR_26025	COG2409	Drug exporters of the RND superfamily
AFR_26055	COG1280	lysine exporter protein (LysE YggA)
AFR_26075	COG1653	transport
AFR_26085	COG3548	integral membrane protein
AFR_26115	COG4948	Mandelate Racemase Muconate Lactonizing
AFR_26125	COG1175	transmembrane transport
AFR_26130	COG1653	transport
AFR_26145	COG2084	Dehydrogenase
AFR_26195	COG2197	response regulator
AFR_26200	COG4585	Histidine kinase
AFR_26205	COG1136	(ABC) transporter
AFR_26205	COG0577	efflux transmembrane transporter activity
AFR_26215	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_26225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_26235	COG0515	serine threonine protein kinase
AFR_26245	COG2304	oxidoreductase activity
AFR_26255	COG2318	DinB family
AFR_26270	COG0483	inositol monophosphate 1-phosphatase activity
AFR_26285	COG3866	Pectate lyase
AFR_26310	COG1609	Transcriptional regulator
AFR_26320	COG4581	dead DEAH box helicase
AFR_26325	COG0546	phosphoglycolate phosphatase activity
AFR_26340	COG0805	protein transport
AFR_26345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFR_26355	COG2378	regulation of single-species biofilm formation
AFR_26390	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFR_26400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFR_26405	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFR_26415	COG4122	O-methyltransferase activity
AFR_26420	COG1222	aaa ATPase
AFR_26425	COG1141	Ferredoxin
AFR_26440	COG1994	Peptidase M50
AFR_26440	COG0517	IMP dehydrogenase activity
AFR_26450	COG2197	response regulator
AFR_26465	COG1136	(ABC) transporter
AFR_26470	COG0577	efflux transmembrane transporter activity
AFR_26470	COG1136	(ABC) transporter
AFR_26545	COG1280	lysine exporter protein (LysE YggA)
AFR_26595	COG1136	(ABC) transporter
AFR_26620	COG1846	Transcriptional regulator
AFR_26625	COG1902	pentaerythritol trinitrate reductase activity
AFR_26630	COG0215	cysteine-tRNA ligase activity
AFR_26650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_26655	COG0667	Aldo Keto reductase
AFR_26680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFR_26695	COG0542	response to heat
AFR_26710	COG1674	ftsk spoiiie
AFR_26755	COG0745	RESPONSE REGULATOR receiver
AFR_26775	COG0653	protein targeting
AFR_26780	COG1132	(ABC) transporter
AFR_26840	COG0596	Alpha beta hydrolase
AFR_26875	COG2197	response regulator
AFR_26880	COG4585	Histidine kinase
AFR_26885	COG1396	sequence-specific DNA binding
AFR_26915	COG1797	cobyrinic acid a,c-diamide synthase activity
AFR_26930	COG1070	Carbohydrate kinase
AFR_26940	COG1191	sigma factor activity
AFR_26950	COG0640	Transcriptional regulator
AFR_26955	COG1819	glycosyl
AFR_26970	COG5001	Diguanylate cyclase
AFR_26975	COG0708	Exodeoxyribonuclease III
AFR_27010	COG5001	Diguanylate cyclase
AFR_27010	COG3300	MHYT domain
AFR_27015	COG1643	Atp-dependent helicase
AFR_27020	COG0656	L-ascorbic acid biosynthetic process
AFR_27030	COG5002	protein histidine kinase activity
AFR_27050	COG1191	sigma factor activity
AFR_27060	COG1404	Belongs to the peptidase S8 family
AFR_27110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AFR_27115	COG0456	acetyltransferase
AFR_27135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_27160	COG2183	response to ionizing radiation
AFR_27190	COG2068	MobA-Related Protein
AFR_27300	COG5297	Belongs to the glycosyl hydrolase family 6
AFR_27345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFR_27355	COG1609	Transcriptional regulator
AFR_27380	COG0673	inositol 2-dehydrogenase activity
AFR_27405	COG1960	acyl-CoA dehydrogenase activity
AFR_27435	COG0584	glycerophosphoryl diester phosphodiesterase
AFR_27445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFR_27450	COG1414	Transcriptional regulator
AFR_27455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AFR_27460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFR_27465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AFR_27495	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_27520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFR_27550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFR_27555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFR_27570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_27580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_27585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFR_27610	COG5001	Diguanylate cyclase
AFR_27610	COG3706	GGDEF domain
AFR_27610	COG4251	negative regulation of phosphorylation
AFR_27610	COG2203	Gaf domain
AFR_27630	COG4213	ABC transporter substrate-binding protein
AFR_27635	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_27645	COG2409	Drug exporters of the RND superfamily
AFR_27660	COG1132	(ABC) transporter
AFR_27665	COG5002	protein histidine kinase activity
AFR_27685	COG0577	efflux transmembrane transporter activity
AFR_27685	COG1136	(ABC) transporter
AFR_27690	COG0577	efflux transmembrane transporter activity
AFR_27690	COG1136	(ABC) transporter
AFR_27695	COG1252	NADH dehydrogenase
AFR_27735	COG0366	Alpha amylase catalytic
AFR_27780	COG1012	belongs to the aldehyde dehydrogenase family
AFR_27795	COG1522	sequence-specific DNA binding
AFR_27800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFR_27805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_27830	COG1725	Transcriptional regulator
AFR_27870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_27875	COG0438	transferase activity, transferring glycosyl groups
AFR_27895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFR_27915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AFR_27930	COG0515	serine threonine protein kinase
AFR_27935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_27950	COG1921	L-seryl-tRNASec selenium transferase activity
AFR_27955	COG0709	Synthesizes selenophosphate from selenide and ATP
AFR_27965	COG0437	4 iron, 4 sulfur cluster binding
AFR_27970	COG3383	formate dehydrogenase (NAD+) activity
AFR_27970	COG0243	molybdopterin cofactor binding
AFR_27975	COG0243	molybdopterin cofactor binding
AFR_27975	COG3383	formate dehydrogenase (NAD+) activity
AFR_27990	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_28000	COG1141	Ferredoxin
AFR_28015	COG1715	Restriction endonuclease
AFR_28120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFR_28180	COG3152	Membrane
AFR_28205	COG0714	Associated with various cellular activities
AFR_28215	COG0642	Histidine kinase
AFR_28225	COG3903	Transcriptional regulator
AFR_28225	COG3629	intracellular signal transduction
AFR_28235	COG0745	RESPONSE REGULATOR receiver
AFR_28240	COG1733	regulation of RNA biosynthetic process
AFR_28275	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFR_28330	COG0456	acetyltransferase
AFR_28340	COG3903	Transcriptional regulator
AFR_28340	COG2197	response regulator
AFR_28365	COG2124	cytochrome p450
AFR_28375	COG1960	acyl-CoA dehydrogenase activity
AFR_28385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFR_28415	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFR_28430	COG3119	arylsulfatase activity
AFR_28480	COG4251	negative regulation of phosphorylation
AFR_28480	COG2203	Gaf domain
AFR_28480	COG3706	GGDEF domain
AFR_28480	COG5001	Diguanylate cyclase
AFR_28485	COG1082	Xylose isomerase domain protein TIM barrel
AFR_28490	COG2133	pyrroloquinoline quinone binding
AFR_28500	COG2205	protein histidine kinase activity
AFR_28505	COG0745	RESPONSE REGULATOR receiver
AFR_28525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFR_28530	COG0778	Nitroreductase
AFR_28540	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_28540	COG0604	alcohol dehydrogenase
AFR_28540	COG3321	synthase
AFR_28570	COG3285	dna ligase
AFR_28570	COG1793	dna ligase
AFR_28575	COG3226	Transcriptional regulator
AFR_28580	COG2267	carboxylic ester hydrolase activity
AFR_28595	COG0577	efflux transmembrane transporter activity
AFR_28600	COG1136	(ABC) transporter
AFR_28600	COG0577	efflux transmembrane transporter activity
AFR_28610	COG0745	RESPONSE REGULATOR receiver
AFR_28615	COG2205	protein histidine kinase activity
AFR_28620	COG2205	protein histidine kinase activity
AFR_28625	COG0745	RESPONSE REGULATOR receiver
AFR_28635	COG0463	Glycosyl transferase, family 2
AFR_28670	COG2267	carboxylic ester hydrolase activity
AFR_28695	COG1408	metallophosphoesterase
AFR_28710	COG1408	metallophosphoesterase
AFR_28715	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_28765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFR_28770	COG2197	response regulator
AFR_28775	COG4585	Histidine kinase
AFR_28800	COG2197	response regulator
AFR_28825	COG4585	Histidine kinase
AFR_28830	COG2197	response regulator
AFR_28870	COG1131	(ABC) transporter
AFR_28890	COG1073	alpha beta
AFR_28905	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_28910	COG1309	transcriptional regulator
AFR_28955	COG4585	Histidine kinase
AFR_28970	COG2267	carboxylic ester hydrolase activity
AFR_28975	COG0596	Alpha beta hydrolase
AFR_29005	COG2226	methyltransferase
AFR_29080	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AFR_29085	COG2186	Transcriptional regulator
AFR_29095	COG3618	amidohydrolase
AFR_29110	COG0395	ABC-type sugar transport system, permease component
AFR_29125	COG1063	alcohol dehydrogenase
AFR_29130	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_29135	COG1733	regulation of RNA biosynthetic process
AFR_29140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_29165	COG3345	alpha-galactosidase
AFR_29185	COG3507	Belongs to the glycosyl hydrolase 43 family
AFR_29220	COG1132	(ABC) transporter
AFR_29235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_29240	COG1234	tRNA 3'-trailer cleavage
AFR_29265	COG0583	DNA-binding transcription factor activity
AFR_29275	COG0300	oxidoreductase activity
AFR_29285	COG0114	fumarate hydratase activity
AFR_29295	COG0154	amidase activity
AFR_29300	COG0702	epimerase
AFR_29320	COG4977	sequence-specific DNA binding
AFR_29320	COG1917	Cupin 2, conserved barrel domain protein
AFR_29370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_29405	COG1136	(ABC) transporter
AFR_29405	COG0577	efflux transmembrane transporter activity
AFR_29410	COG1136	(ABC) transporter
AFR_29420	COG0745	RESPONSE REGULATOR receiver
AFR_29425	COG5002	protein histidine kinase activity
AFR_29450	COG3629	intracellular signal transduction
AFR_29450	COG3903	Transcriptional regulator
AFR_29475	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_29480	COG1741	Belongs to the pirin family
AFR_29500	COG2814	Major facilitator Superfamily
AFR_29565	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AFR_29575	COG1201	RNA secondary structure unwinding
AFR_29620	COG1160	GTP binding
AFR_29625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFR_29635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFR_29640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFR_29650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_29680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFR_29720	COG0484	heat shock protein binding
AFR_29885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_29890	COG1051	belongs to the nudix hydrolase family
AFR_29895	COG0504	CTP synthase activity
AFR_29905	COG0438	transferase activity, transferring glycosyl groups
AFR_29935	COG0497	DNA recombination
AFR_29940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFR_29965	COG1131	(ABC) transporter
AFR_29975	COG4585	Histidine kinase
AFR_29980	COG2197	response regulator
AFR_29985	COG0647	UMP catabolic process
AFR_30000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFR_30015	COG2326	polyphosphate kinase activity
AFR_30020	COG0563	adenylate kinase activity
AFR_30055	COG2094	Belongs to the DNA glycosylase MPG family
AFR_30070	COG3537	Alpha-1,2-mannosidase
AFR_30080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFR_30085	COG0406	alpha-ribazole phosphatase activity
AFR_30100	COG1175	transmembrane transport
AFR_30105	COG0395	ABC-type sugar transport system, permease component
AFR_30115	COG0490	domain, Protein
AFR_30120	COG3851	Histidine kinase
AFR_30125	COG2197	response regulator
AFR_30130	COG2111	Na H antiporter
AFR_30130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFR_30150	COG2212	antiporter activity
AFR_30155	COG1320	monovalent cation:proton antiporter activity
AFR_30185	COG0583	DNA-binding transcription factor activity
AFR_30190	COG0730	response to heat
AFR_30200	COG1192	Involved in chromosome partitioning
AFR_30205	COG0165	Argininosuccinate lyase
AFR_30210	COG0137	argininosuccinate synthase activity
AFR_30220	COG1438	arginine binding
AFR_30225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFR_30230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFR_30235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFR_30240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFR_30245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFR_30310	COG4585	Histidine kinase
AFR_30315	COG2197	response regulator
AFR_30385	COG1725	Transcriptional regulator
AFR_30390	COG1131	(ABC) transporter
AFR_30415	COG2226	methyltransferase
AFR_30425	COG2318	DinB family
AFR_30440	COG0072	phenylalanine-tRNA ligase activity
AFR_30440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFR_30445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFR_30450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFR_30455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFR_30460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFR_30465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFR_30475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFR_30480	COG0140	phosphoribosyl-ATP diphosphatase activity
AFR_30490	COG0765	amino acid transport
AFR_30500	COG2133	pyrroloquinoline quinone binding
AFR_30505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFR_30510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_30510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFR_30525	COG0745	RESPONSE REGULATOR receiver
AFR_30550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFR_30555	COG0242	peptide deformylase activity
AFR_30575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFR_30585	COG1758	RNA polymerase activity
AFR_30590	COG0194	GDP metabolic process
AFR_30595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFR_30600	COG0284	orotidine-5'-phosphate decarboxylase activity
AFR_30605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFR_30610	COG0167	dihydroorotate dehydrogenase activity
AFR_30620	COG0505	Belongs to the CarA family
AFR_30625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFR_30630	COG0540	Belongs to the ATCase OTCase family
AFR_30635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFR_30645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFR_30650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFR_30655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFR_30660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFR_30680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFR_30685	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFR_30690	COG2814	Major facilitator Superfamily
AFR_30695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFR_30700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFR_30705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFR_30710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFR_30775	COG2205	protein histidine kinase activity
AFR_30780	COG0745	RESPONSE REGULATOR receiver
AFR_30805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFR_30860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AFR_30870	COG1175	transmembrane transport
AFR_30890	COG3964	amidohydrolase
AFR_30905	COG0831	urea catabolic process
AFR_30910	COG0832	Belongs to the urease beta subunit family
AFR_30915	COG0804	urea catabolic process
AFR_30925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AFR_30930	COG0829	nickel cation binding
AFR_30935	COG1191	sigma factor activity
AFR_30945	COG0515	serine threonine protein kinase
AFR_30960	COG2814	Major facilitator Superfamily
AFR_30975	COG0410	ABC transporter
AFR_31005	COG4221	oxidoreductase activity
AFR_31015	COG0124	histidyl-tRNA synthetase
AFR_31030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFR_31035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFR_31040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFR_31055	COG1862	Preprotein translocase
AFR_31060	COG2255	four-way junction helicase activity
AFR_31065	COG0632	four-way junction helicase activity
AFR_31070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFR_31080	COG0217	transcriptional regulatory protein
AFR_31085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFR_31090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFR_31095	COG1987	bacterial-type flagellum assembly
AFR_31105	COG0438	transferase activity, transferring glycosyl groups
AFR_31110	COG1560	Kdo2-lipid A biosynthetic process
AFR_31135	COG5001	Diguanylate cyclase
AFR_31165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFR_31195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFR_31200	COG4106	trans-aconitate 2-methyltransferase activity
AFR_31205	COG0667	Aldo Keto reductase
AFR_31215	COG1278	Cold shock
AFR_31255	COG1472	Belongs to the glycosyl hydrolase 3 family
AFR_31265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_31270	COG0514	ATP-dependent DNA helicase (RecQ)
AFR_31300	COG2197	response regulator
AFR_31305	COG3850	Histidine kinase
AFR_31315	COG1131	(ABC) transporter
AFR_31320	COG0297	glycogen (starch) synthase activity
AFR_31330	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_31340	COG1295	ribonuclease BN
AFR_31385	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_31435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_31455	COG2910	NAD(P)H-binding
AFR_31480	COG2197	response regulator
AFR_31485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AFR_31500	COG4266	Belongs to the allantoicase family
AFR_31505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFR_31550	COG1643	Atp-dependent helicase
AFR_31575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFR_31610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFR_31615	COG1216	Glycosyl transferase, family 2
AFR_31650	COG3300	MHYT domain
AFR_31650	COG5001	Diguanylate cyclase
AFR_31670	COG0840	transmembrane signaling receptor activity
AFR_31695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFR_31700	COG5002	protein histidine kinase activity
AFR_31715	COG0405	Gamma-glutamyltransferase
AFR_31725	COG1132	(ABC) transporter
AFR_31765	COG2936	dipeptidyl-peptidase activity
AFR_31770	COG1082	Xylose isomerase domain protein TIM barrel
AFR_31785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_31790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_31795	COG1216	Glycosyl transferase, family 2
AFR_31800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_31825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_31840	COG1686	Belongs to the peptidase S11 family
AFR_31860	COG1191	sigma factor activity
AFR_31865	COG3973	AAA domain
AFR_31875	COG1191	sigma factor activity
AFR_31880	COG0513	Belongs to the DEAD box helicase family
AFR_31895	COG2197	response regulator
AFR_31925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AFR_31930	COG1609	Transcriptional regulator
AFR_31935	COG4166	transmembrane transport
AFR_31945	COG0601	transmembrane transport
AFR_31950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFR_31960	COG2723	6-phospho-beta-galactosidase activity
AFR_31965	COG1940	carbohydrate kinase activity
AFR_31990	COG0667	Aldo Keto reductase
AFR_32030	COG0187	DNA topoisomerase II activity
AFR_32050	COG2197	response regulator
AFR_32065	COG2205	protein histidine kinase activity
AFR_32070	COG0745	RESPONSE REGULATOR receiver
AFR_32075	COG4941	Belongs to the sigma-70 factor family
AFR_32080	COG3795	YCII-related domain
AFR_32130	COG0387	Pfam Sodium calcium exchanger
AFR_32155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_32170	COG0435	Glutathione S-transferase
AFR_32180	COG1846	Transcriptional regulator
AFR_32185	COG0697	spore germination
AFR_32195	COG1309	transcriptional regulator
AFR_32210	COG0714	Associated with various cellular activities
AFR_32225	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AFR_32230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFR_32230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFR_32275	COG1120	ATPase activity
AFR_32280	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_32285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFR_32330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFR_32375	COG1595	DNA-templated transcription, initiation
AFR_32385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFR_32390	COG0543	2 iron, 2 sulfur cluster binding
AFR_32390	COG0633	Ferredoxin
AFR_32410	COG4221	oxidoreductase activity
AFR_32430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFR_32440	COG0515	serine threonine protein kinase
AFR_32485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFR_32490	COG1136	(ABC) transporter
AFR_32500	COG1136	(ABC) transporter
AFR_32515	COG0598	Magnesium transport protein CorA
AFR_32545	COG2304	oxidoreductase activity
AFR_32560	COG0714	Associated with various cellular activities
AFR_32570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AFR_32575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFR_32645	COG0745	RESPONSE REGULATOR receiver
AFR_32645	COG3706	GGDEF domain
AFR_32655	COG0671	phosphoesterase, PA-phosphatase related
AFR_32665	COG1597	lipid kinase activity
AFR_32665	COG1803	Methylglyoxal synthase
AFR_32715	COG2124	cytochrome p450
AFR_32735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_32750	COG1116	anion transmembrane transporter activity
AFR_32760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_32765	COG1960	acyl-CoA dehydrogenase activity
AFR_32770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_32780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_32815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFR_32825	COG2197	response regulator
AFR_32850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFR_32875	COG0546	phosphoglycolate phosphatase activity
AFR_32880	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AFR_32895	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_32910	COG0800	Aldolase
AFR_32965	COG2814	Major facilitator Superfamily
AFR_32975	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AFR_33015	COG0438	transferase activity, transferring glycosyl groups
AFR_33030	COG2197	response regulator
AFR_33035	COG2706	6-phosphogluconolactonase activity
AFR_33040	COG4585	Histidine kinase
AFR_33050	COG2226	methyltransferase
AFR_33055	COG5002	protein histidine kinase activity
AFR_33055	COG5001	Diguanylate cyclase
AFR_33055	COG3447	MASE1 domain protein
AFR_33065	COG0673	inositol 2-dehydrogenase activity
AFR_33085	COG3483	tryptophan 2,3-dioxygenase activity
AFR_33090	COG3012	SEC-C Motif Domain Protein
AFR_33095	COG0789	Transcriptional regulator
AFR_33125	COG1653	transport
AFR_33130	COG1175	transmembrane transport
AFR_33135	COG0395	ABC-type sugar transport system, permease component
AFR_33140	COG0366	Alpha amylase catalytic
AFR_33155	COG2197	response regulator
AFR_33160	COG4585	Histidine kinase
AFR_33170	COG0659	secondary active sulfate transmembrane transporter activity
AFR_33180	COG0574	Belongs to the PEP-utilizing enzyme family
AFR_33180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFR_33185	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_33185	COG2308	Evidence 4 Homologs of previously reported genes of
AFR_33190	COG0367	asparagine synthase
AFR_33195	COG1506	peptidase
AFR_33220	COG3852	Histidine kinase
AFR_33235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFR_33245	COG1278	Cold shock
AFR_33260	COG2814	Major facilitator Superfamily
AFR_33270	COG2375	cellular response to nickel ion
AFR_33325	COG1063	alcohol dehydrogenase
AFR_33330	COG4585	Histidine kinase
AFR_33335	COG2197	response regulator
AFR_33345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AFR_33365	COG0539	negative regulation of cytoplasmic translation
AFR_33380	COG2318	DinB family
AFR_33390	COG1136	(ABC) transporter
AFR_33400	COG0640	Transcriptional regulator
AFR_33510	COG2197	response regulator
AFR_33515	COG4585	Histidine kinase
AFR_33540	COG0328	RNA-DNA hybrid ribonuclease activity
AFR_33550	COG2132	Multicopper oxidase
AFR_33565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_33570	COG0596	Alpha beta hydrolase
AFR_33580	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFR_33650	COG1793	dna ligase
AFR_33650	COG3285	dna ligase
AFR_33665	COG2197	response regulator
AFR_33675	COG3537	Alpha-1,2-mannosidase
AFR_33680	COG3467	pyridoxamine 5'-phosphate
AFR_33770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFR_33775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AFR_33815	COG0702	epimerase
AFR_33860	COG1830	Aldolase
AFR_33870	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFR_33880	COG0277	FAD linked oxidase domain protein
AFR_33890	COG0456	acetyltransferase
AFR_33900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_33930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AFR_33940	COG4585	Histidine kinase
AFR_33945	COG2201	protein-glutamate methylesterase activity
AFR_33980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFR_34010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFR_34030	COG4974	Belongs to the 'phage' integrase family
AFR_34055	COG2409	Drug exporters of the RND superfamily
AFR_34065	COG0243	molybdopterin cofactor binding
AFR_34075	COG1404	Belongs to the peptidase S8 family
AFR_34115	COG0745	RESPONSE REGULATOR receiver
AFR_34120	COG2205	protein histidine kinase activity
AFR_34130	COG1733	regulation of RNA biosynthetic process
AFR_34145	COG4977	sequence-specific DNA binding
AFR_34155	COG5001	Diguanylate cyclase
AFR_34155	COG3300	MHYT domain
AFR_34175	COG1501	Belongs to the glycosyl hydrolase 31 family
AFR_34180	COG1131	(ABC) transporter
AFR_34195	COG2197	response regulator
AFR_34210	COG4585	Histidine kinase
AFR_34215	COG2197	response regulator
AFR_34250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFR_34255	COG0439	Biotin carboxylase
AFR_34260	COG0215	cysteine-tRNA ligase activity
AFR_34300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AFR_34300	COG0515	serine threonine protein kinase
AFR_34345	COG1802	Transcriptional regulator
AFR_34375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFR_34385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_34400	COG2207	Transcriptional regulator
AFR_34405	COG0667	Aldo Keto reductase
AFR_34415	COG3118	belongs to the thioredoxin family
AFR_34430	COG3706	GGDEF domain
AFR_34445	COG1136	(ABC) transporter
AFR_34450	COG1136	(ABC) transporter
AFR_34455	COG0789	Transcriptional regulator
AFR_34550	COG1404	Belongs to the peptidase S8 family
AFR_34560	COG5001	Diguanylate cyclase
AFR_34575	COG1116	anion transmembrane transporter activity
AFR_34580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_34590	COG0010	Belongs to the arginase family
AFR_34620	COG2197	response regulator
AFR_34635	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_34650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFR_34655	COG0483	inositol monophosphate 1-phosphatase activity
AFR_34660	COG0671	phosphoesterase, PA-phosphatase related
AFR_34690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFR_34700	COG0395	ABC-type sugar transport system, permease component
AFR_34705	COG1175	transmembrane transport
AFR_34715	COG4821	SIS domain
AFR_34720	COG1737	Transcriptional regulator
AFR_34735	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_34755	COG1063	alcohol dehydrogenase
AFR_34780	COG0300	oxidoreductase activity
AFR_34790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AFR_34795	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AFR_34800	COG2080	2 iron, 2 sulfur cluster binding
AFR_34820	COG2264	protein methyltransferase activity
AFR_34825	COG1914	H( )-stimulated, divalent metal cation uptake system
AFR_34830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AFR_34835	COG4336	lyase activity
AFR_34840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AFR_34845	COG1984	allophanate hydrolase subunit 2
AFR_34915	COG0419	ATPase involved in DNA repair
AFR_34920	COG0420	3'-5' exonuclease activity
AFR_34955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFR_34960	COG0156	8-amino-7-oxononanoate synthase activity
AFR_34965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFR_34970	COG0456	acetyltransferase
AFR_34975	COG1253	flavin adenine dinucleotide binding
AFR_34985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_34985	COG1522	sequence-specific DNA binding
AFR_35025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFR_35050	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_35055	COG1793	dna ligase
AFR_35065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFR_35080	COG0577	efflux transmembrane transporter activity
AFR_35080	COG1136	(ABC) transporter
AFR_35085	COG4585	Histidine kinase
AFR_35110	COG3285	dna ligase
AFR_35110	COG1793	dna ligase
AFR_35135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AFR_35150	COG0655	NAD(P)H dehydrogenase (quinone) activity
AFR_35175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFR_35185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_35190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AFR_35200	COG0183	Belongs to the thiolase family
AFR_35205	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_35205	COG1024	Enoyl-CoA hydratase
AFR_35225	COG2205	protein histidine kinase activity
AFR_35230	COG0745	RESPONSE REGULATOR receiver
AFR_35250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFR_35255	COG1301	dicarboxylic acid transport
AFR_35260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AFR_35265	COG0531	amino acid
AFR_35270	COG0569	domain protein
AFR_35295	COG0756	dUTP diphosphatase activity
AFR_35340	COG2860	membrane
AFR_35350	COG2313	pseudouridylate synthase activity
AFR_35380	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AFR_35405	COG1490	D-aminoacyl-tRNA deacylase activity
AFR_35425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFR_35460	COG0738	Major facilitator superfamily
AFR_35510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFR_35520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFR_35535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFR_35550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFR_35555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFR_35560	COG1196	nuclear chromosome segregation
AFR_35575	COG1733	regulation of RNA biosynthetic process
AFR_35580	COG0583	DNA-binding transcription factor activity
AFR_35585	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_35595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFR_35605	COG1126	abc transporter atp-binding protein
AFR_35610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_35615	COG0765	amino acid transport
AFR_35620	COG0765	amino acid transport
AFR_35635	COG1418	mRNA catabolic process
AFR_35650	COG2137	regulation of response to DNA damage stimulus
AFR_35655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFR_35670	COG1573	uracil-dna glycosylase
AFR_35705	COG4326	sporulation control protein
AFR_35725	COG2815	serine threonine protein kinase
AFR_35725	COG0515	serine threonine protein kinase
AFR_35740	COG1201	RNA secondary structure unwinding
AFR_35755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFR_35780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_35795	COG1396	sequence-specific DNA binding
AFR_35800	COG1546	Belongs to the CinA family
AFR_35800	COG1058	Belongs to the CinA family
AFR_35810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFR_35820	COG1674	ftsk spoiiie
AFR_35840	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFR_35845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFR_35855	COG3214	Protein conserved in bacteria
AFR_35870	COG0395	ABC-type sugar transport system, permease component
AFR_35895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFR_35905	COG0612	Peptidase, M16
AFR_35910	COG1185	polyribonucleotide nucleotidyltransferase activity
AFR_35915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFR_35925	COG2205	protein histidine kinase activity
AFR_35925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFR_35955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AFR_35960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFR_35975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFR_35990	COG0779	Required for maturation of 30S ribosomal subunits
AFR_36035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFR_36040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFR_36050	COG1012	belongs to the aldehyde dehydrogenase family
AFR_36090	COG4585	Histidine kinase
AFR_36095	COG2197	response regulator
AFR_36100	COG4152	abc transporter atp-binding protein
AFR_36105	COG1668	transmembrane transport
AFR_36110	COG1309	transcriptional regulator
AFR_36115	COG1511	domain protein
AFR_36120	COG1121	(ABC) transporter
AFR_36130	COG0456	acetyltransferase
AFR_36140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFR_36145	COG0750	zinc metalloprotease
AFR_36165	COG2409	Drug exporters of the RND superfamily
AFR_36180	COG2146	nitrite reductase [NAD(P)H] activity
AFR_36180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFR_36195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFR_36205	COG0233	cytoplasmic translational termination
AFR_36210	COG0528	UMP kinase activity
AFR_36215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFR_36220	COG0052	Belongs to the universal ribosomal protein uS2 family
AFR_36230	COG0792	nuclease activity
AFR_36235	COG0606	chelatase, subunit chli
AFR_36270	COG4974	Belongs to the 'phage' integrase family
AFR_36290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFR_36300	COG0681	Belongs to the peptidase S26 family
AFR_36305	COG0681	Belongs to the peptidase S26 family
AFR_36310	COG0335	large ribosomal subunit rRNA binding
AFR_36315	COG0336	Belongs to the RNA methyltransferase TrmD family
AFR_36320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFR_36325	COG1837	Belongs to the UPF0109 family
AFR_36330	COG0228	four-way junction DNA binding
AFR_36345	COG0442	prolyl-tRNA aminoacylation
AFR_36380	COG0438	transferase activity, transferring glycosyl groups
AFR_36390	COG2755	lipolytic protein G-D-S-L family
AFR_36390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AFR_36405	COG0463	Glycosyl transferase, family 2
AFR_36410	COG3739	integral membrane protein
AFR_36415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AFR_36445	COG2318	DinB family
AFR_36495	COG2340	Cysteine-rich secretory protein family
AFR_36515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_36525	COG0571	ribonuclease III activity
AFR_36530	COG0416	fatty acid biosynthetic process
AFR_36535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFR_36550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFR_36555	COG0742	ribosomal rna small subunit methyltransferase
AFR_36585	COG1461	Dihydroxyacetone kinase
AFR_36590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFR_36615	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFR_36630	COG1131	(ABC) transporter
AFR_36645	COG0626	cystathionine gamma-synthase activity
AFR_36650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFR_36670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFR_36685	COG0776	regulation of translation
AFR_36690	COG0066	3-isopropylmalate dehydratase activity
AFR_36720	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFR_36725	COG1476	TRANSCRIPTIONal
AFR_36735	COG1131	(ABC) transporter
AFR_36755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFR_36760	COG5006	permease, DMT superfamily
AFR_36770	COG2205	protein histidine kinase activity
AFR_36775	COG0745	RESPONSE REGULATOR receiver
AFR_36780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_36785	COG2304	oxidoreductase activity
AFR_36795	COG0714	Associated with various cellular activities
AFR_36800	COG0612	Peptidase, M16
AFR_36835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_36855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFR_36860	COG0473	3-isopropylmalate dehydrogenase activity
AFR_36870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_36890	COG0440	acetolactate synthase activity
AFR_36905	COG0129	dihydroxy-acid dehydratase activity
AFR_36915	COG0395	ABC-type sugar transport system, permease component
AFR_36920	COG1175	transmembrane transport
AFR_36930	COG1609	Transcriptional regulator
AFR_36935	COG2203	Gaf domain
AFR_36935	COG3706	GGDEF domain
AFR_36935	COG4251	negative regulation of phosphorylation
AFR_36935	COG5001	Diguanylate cyclase
AFR_36955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFR_36960	COG2133	pyrroloquinoline quinone binding
AFR_36970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFR_36975	COG0154	amidase activity
AFR_36980	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFR_36995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFR_37015	COG0482	sulfurtransferase activity
AFR_37025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFR_37035	COG2149	membrane
AFR_37055	COG0443	Heat shock 70 kDa protein
AFR_37085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFR_37090	COG1119	ATPase activity
AFR_37115	COG1309	transcriptional regulator
AFR_37135	COG2902	Dehydrogenase
AFR_37145	COG0010	Belongs to the arginase family
AFR_37210	COG0183	Belongs to the thiolase family
AFR_37260	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AFR_37275	COG1674	ftsk spoiiie
AFR_37295	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFR_37325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFR_37335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFR_37340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFR_37345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFR_37350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFR_37355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFR_37360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFR_37365	COG0356	it plays a direct role in the translocation of protons across the membrane
AFR_37380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFR_37385	COG0702	epimerase
AFR_37390	COG0009	L-threonylcarbamoyladenylate synthase
AFR_37395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFR_37405	COG2890	protein-(glutamine-N5) methyltransferase activity
AFR_37410	COG3706	GGDEF domain
AFR_37420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFR_37425	COG0254	rRNA binding
AFR_37445	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AFR_37455	COG0083	homoserine kinase activity
AFR_37470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFR_37475	COG1846	Transcriptional regulator
AFR_37480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFR_37485	COG0460	homoserine dehydrogenase
AFR_37495	COG0018	arginyl-trna synthetase
AFR_37545	COG4221	oxidoreductase activity
AFR_37555	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_37560	COG0492	ferredoxin-NADP+ reductase activity
AFR_37565	COG2986	histidine ammonia-lyase
AFR_37585	COG0475	glutathione-regulated potassium exporter activity
AFR_37590	COG0745	RESPONSE REGULATOR receiver
AFR_37595	COG5002	protein histidine kinase activity
AFR_37605	COG0515	serine threonine protein kinase
AFR_37605	COG2815	serine threonine protein kinase
AFR_37640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFR_37645	COG1733	regulation of RNA biosynthetic process
AFR_37650	COG1073	alpha beta
AFR_37660	COG4221	oxidoreductase activity
AFR_37665	COG0583	DNA-binding transcription factor activity
AFR_37680	COG1742	UPF0060 membrane protein
AFR_37705	COG0456	acetyltransferase
AFR_37735	COG1595	DNA-templated transcription, initiation
AFR_37750	COG0673	inositol 2-dehydrogenase activity
AFR_37770	COG1595	DNA-templated transcription, initiation
AFR_37775	COG0754	glutathionylspermidine amidase activity
AFR_37815	COG0586	Pfam SNARE associated Golgi protein
AFR_37820	COG3469	chitinase activity
AFR_37830	COG0706	membrane insertase activity
AFR_37840	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_37850	COG0726	polysaccharide deacetylase
AFR_37860	COG0740	serine-type endopeptidase activity
AFR_37870	COG1834	amidinotransferase
AFR_37875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFR_37885	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFR_37915	COG3842	ATPase activity
AFR_37935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_37940	COG2205	protein histidine kinase activity
AFR_37945	COG0745	RESPONSE REGULATOR receiver
AFR_37960	COG1131	(ABC) transporter
AFR_37970	COG0567	Dehydrogenase, E1 component
AFR_37970	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFR_37990	COG1132	(ABC) transporter
AFR_37995	COG0857	belongs to the CobB CobQ family
AFR_37995	COG0280	phosphate acetyltransferase
AFR_38000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFR_38040	COG2172	sigma factor antagonist activity
AFR_38045	COG2188	Transcriptional regulator
AFR_38055	COG1597	lipid kinase activity
AFR_38070	COG0175	sulfate reduction
AFR_38100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFR_38110	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AFR_38120	COG1595	DNA-templated transcription, initiation
AFR_38135	COG2135	peptidase activity
AFR_38140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFR_38145	COG1162	GTPase activity
AFR_38150	COG0483	inositol monophosphate 1-phosphatase activity
AFR_38170	COG2197	response regulator
AFR_38195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_38260	COG2409	Drug exporters of the RND superfamily
AFR_38265	COG0861	Integral membrane protein TerC family
AFR_38275	COG1357	PFAM Pentapeptide repeats (8 copies)
AFR_38290	COG4221	oxidoreductase activity
AFR_38305	COG1615	UPF0182 protein
AFR_38310	COG3480	Lon protease (S16) C-terminal proteolytic domain
AFR_38340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFR_38375	COG4585	Histidine kinase
AFR_38385	COG5285	phytanoyl-CoA dioxygenase
AFR_38390	COG2816	NAD+ diphosphatase activity
AFR_38410	COG1678	Uncharacterized ACR, COG1678
AFR_38425	COG0726	polysaccharide deacetylase
AFR_38435	COG1959	2 iron, 2 sulfur cluster binding
AFR_38445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AFR_38450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFR_38465	COG1278	Cold shock
AFR_38480	COG0210	DNA helicase
AFR_38485	COG1609	Transcriptional regulator
AFR_38495	COG1611	Belongs to the LOG family
AFR_38500	COG1611	Belongs to the LOG family
AFR_38505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFR_38530	COG2171	N-acyltransferase activity
AFR_38575	COG0667	Aldo Keto reductase
AFR_38585	COG4221	oxidoreductase activity
AFR_38590	COG0640	Transcriptional regulator
AFR_38615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AFR_38620	COG0121	glutamine amidotransferase
AFR_38625	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AFR_38630	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_38630	COG3347	Dehydrogenase
AFR_38655	COG0438	transferase activity, transferring glycosyl groups
AFR_38715	COG0656	L-ascorbic acid biosynthetic process
AFR_38725	COG1404	Belongs to the peptidase S8 family
AFR_38760	COG0583	DNA-binding transcription factor activity
AFR_38780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFR_38795	COG3706	GGDEF domain
AFR_38820	COG1053	succinate dehydrogenase
AFR_38865	COG0410	ABC transporter
AFR_38890	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_38900	COG1960	acyl-CoA dehydrogenase activity
AFR_38930	COG4585	Histidine kinase
AFR_38935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFR_38960	COG0463	Glycosyl transferase, family 2
AFR_38965	COG3483	tryptophan 2,3-dioxygenase activity
AFR_38970	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFR_38985	COG1960	acyl-CoA dehydrogenase activity
AFR_38990	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_39155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFR_39175	COG0525	valine-tRNA ligase activity
AFR_39190	COG1322	Protein conserved in bacteria
AFR_39195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFR_39210	COG1570	exodeoxyribonuclease VII activity
AFR_39215	COG1722	exodeoxyribonuclease VII activity
AFR_39235	COG0705	Rhomboid family
AFR_39250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFR_39255	COG0561	phosphatase activity
AFR_39255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFR_39275	COG0644	oxidoreductase
AFR_39290	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AFR_39295	COG1595	DNA-templated transcription, initiation
AFR_39325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFR_39365	COG0424	maF-like protein
AFR_39385	COG4770	biotin carboxylase activity
AFR_39400	COG1305	Transglutaminase-like
AFR_39455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AFR_39455	COG1473	amidohydrolase
AFR_39460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_39460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFR_39465	COG0515	serine threonine protein kinase
AFR_39465	COG2815	serine threonine protein kinase
AFR_39470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFR_39485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AFR_39495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AFR_39500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AFR_39505	COG1012	belongs to the aldehyde dehydrogenase family
AFR_39510	COG1012	belongs to the aldehyde dehydrogenase family
AFR_39540	COG2018	Roadblock/LC7 domain
AFR_39545	COG0642	Histidine kinase
AFR_39550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AFR_39590	COG1744	ABC transporter substrate-binding protein PnrA-like
AFR_39605	COG1309	transcriptional regulator
AFR_39625	COG0180	Tryptophanyl-tRNA synthetase
AFR_39635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AFR_39645	COG0640	Transcriptional regulator
AFR_39660	COG3507	Belongs to the glycosyl hydrolase 43 family
AFR_39665	COG0395	ABC-type sugar transport system, permease component
AFR_39670	COG1175	transmembrane transport
AFR_39675	COG1653	transport
AFR_39685	COG1609	Transcriptional regulator
AFR_39700	COG1218	3'(2'),5'-bisphosphate nucleotidase
AFR_39705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFR_39710	COG0193	aminoacyl-tRNA hydrolase activity
AFR_39715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFR_39725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFR_39750	COG0596	Alpha beta hydrolase
AFR_39755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFR_39770	COG1309	transcriptional regulator
AFR_39785	COG0488	(ABC) transporter
AFR_39790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFR_39800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFR_39810	COG0084	hydrolase, TatD family'
AFR_39825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFR_39850	COG0726	polysaccharide deacetylase
AFR_39865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AFR_39895	COG0303	'Molybdopterin
AFR_39900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFR_39905	COG3706	GGDEF domain
AFR_39905	COG0745	RESPONSE REGULATOR receiver
AFR_39910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFR_39960	COG2095	MarC family integral membrane protein
AFR_39965	COG0613	PHP domain protein
AFR_39990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFR_40010	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_40040	COG0384	phenazine biosynthesis protein PhzF
AFR_40045	COG2239	Acts as a magnesium transporter
AFR_40060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFR_40065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFR_40075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFR_40090	COG1024	Enoyl-CoA hydratase
AFR_40105	COG0519	Catalyzes the synthesis of GMP from XMP
AFR_40120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFR_40125	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFR_40125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFR_40130	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFR_40135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFR_40165	COG0113	porphobilinogen synthase activity
AFR_40170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AFR_40170	COG1648	precorrin-2 dehydrogenase activity
AFR_40175	COG0181	hydroxymethylbilane synthase activity
AFR_40180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFR_40185	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AFR_40200	COG0318	PFAM AMP-dependent synthetase and ligase
AFR_40205	COG1595	DNA-templated transcription, initiation
AFR_40230	COG0506	proline dehydrogenase activity
AFR_40240	COG1082	Xylose isomerase domain protein TIM barrel
AFR_40265	COG0300	oxidoreductase activity
AFR_40285	COG0588	phosphoglycerate mutase activity
AFR_40295	COG0835	chemotaxis
AFR_40305	COG2814	Major facilitator Superfamily
AFR_40315	COG0438	transferase activity, transferring glycosyl groups
AFR_40335	COG0745	RESPONSE REGULATOR receiver
AFR_40350	COG2205	protein histidine kinase activity
AFR_40370	COG1196	nuclear chromosome segregation
AFR_40370	COG0739	heme binding
AFR_40370	COG0741	lytic transglycosylase activity
AFR_40375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFR_40380	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AFR_40385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFR_40390	COG4786	Flagellar basal body rod
AFR_40390	COG1256	bacterial-type flagellum assembly
AFR_40400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFR_40410	COG1516	flagellar protein fliS
AFR_40420	COG1815	bacterial-type flagellum-dependent cell motility
AFR_40425	COG1558	bacterial-type flagellum-dependent cell motility
AFR_40430	COG1677	Flagellar hook-basal body complex protein FliE
AFR_40435	COG1766	The M ring may be actively involved in energy transduction
AFR_40440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFR_40450	COG1157	protein secretion by the type III secretion system
AFR_40460	COG1196	nuclear chromosome segregation
AFR_40460	COG0741	lytic transglycosylase activity
AFR_40460	COG0739	heme binding
AFR_40470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AFR_40485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFR_40500	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFR_40505	COG1776	CheC inhibitor of MCP methylation
AFR_40505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFR_40515	COG1338	Plays a role in the flagellum-specific transport system
AFR_40525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFR_40530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFR_40560	COG0745	RESPONSE REGULATOR receiver
AFR_40580	COG2201	protein-glutamate methylesterase activity
AFR_40590	COG0835	chemotaxis
AFR_40595	COG0643	Histidine kinase
AFR_40595	COG2198	Histidine kinase
AFR_40600	COG0745	RESPONSE REGULATOR receiver
AFR_40615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFR_40680	COG3246	L-lysine catabolic process to acetate
AFR_40685	COG0354	folic acid binding
AFR_40690	COG0735	belongs to the Fur family
AFR_40695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFR_40700	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AFR_40730	COG2897	thiosulfate sulfurtransferase activity
AFR_40745	COG0745	RESPONSE REGULATOR receiver
AFR_40750	COG0456	acetyltransferase
AFR_40760	COG2814	Major facilitator Superfamily
AFR_40775	COG0581	inorganic phosphate transmembrane transporter activity
AFR_40780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFR_40790	COG0673	inositol 2-dehydrogenase activity
AFR_40795	COG0306	phosphate transporter
AFR_40810	COG1595	DNA-templated transcription, initiation
AFR_40835	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AFR_40840	COG2339	peptidase activity
AFR_40845	COG4129	membrane
AFR_40865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFR_40885	COG0459	protein refolding
AFR_40900	COG0456	acetyltransferase
AFR_40905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFR_40910	COG1131	(ABC) transporter
AFR_40925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_40935	COG1131	(ABC) transporter
AFR_40980	COG2205	protein histidine kinase activity
AFR_40985	COG0745	RESPONSE REGULATOR receiver
AFR_40995	COG1215	transferase activity, transferring glycosyl groups
AFR_41015	COG1349	DNA-binding transcription factor activity
AFR_41085	COG3842	ATPase activity
AFR_41095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFR_41100	COG0215	cysteine-tRNA ligase activity
AFR_41115	COG0114	fumarate hydratase activity
AFR_41135	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AFR_41135	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AFR_41150	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AFR_41155	COG1714	RDD family
AFR_41165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFR_41170	COG0577	efflux transmembrane transporter activity
AFR_41175	COG1136	(ABC) transporter
AFR_41180	COG4585	Histidine kinase
AFR_41185	COG2197	response regulator
AFR_41230	COG1940	carbohydrate kinase activity
AFR_41230	COG1846	Transcriptional regulator
AFR_41245	COG0395	ABC-type sugar transport system, permease component
AFR_41250	COG1486	melibiose metabolic process
AFR_41270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFR_41275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFR_41300	COG1960	acyl-CoA dehydrogenase activity
AFR_41305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFR_41320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFR_41325	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AFR_41335	COG0242	peptide deformylase activity
AFR_41340	COG3830	Belongs to the UPF0237 family
AFR_41345	COG1194	a g-specific adenine glycosylase
AFR_41355	COG0542	response to heat
AFR_41365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFR_41370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFR_41380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFR_41390	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFR_41405	COG0649	NAD binding
AFR_41425	COG1174	glycine betaine transport
AFR_41430	COG1174	glycine betaine transport
AFR_41435	COG0517	IMP dehydrogenase activity
AFR_41435	COG1125	glycine betaine transport
AFR_41465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFR_41470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFR_41500	COG1196	nuclear chromosome segregation
AFR_41500	COG0741	lytic transglycosylase activity
AFR_41500	COG0739	heme binding
AFR_41515	COG1674	ftsk spoiiie
AFR_41535	COG0302	gtp cyclohydrolase
AFR_41540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFR_41550	COG0037	tRNA processing
AFR_41565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AFR_41575	COG1674	ftsk spoiiie
AFR_41600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFR_41605	COG2843	Capsule synthesis protein
AFR_41615	COG0825	malonyl-CoA metabolic process
AFR_41660	COG0003	Pfam Anion-transporting ATPase
AFR_41670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AFR_41675	COG1610	YqeY-like protein
AFR_41705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFR_41730	COG2203	Gaf domain
AFR_41730	COG0840	transmembrane signaling receptor activity
AFR_41755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFR_41775	COG4608	Belongs to the ABC transporter superfamily
AFR_41780	COG0444	Belongs to the ABC transporter superfamily
AFR_41790	COG0747	negative chemotaxis
AFR_41800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFR_41805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFR_41860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFR_41880	COG0813	purine-nucleoside phosphorylase activity
AFR_41885	COG0590	tRNA wobble adenosine to inosine editing
AFR_41915	COG0287	Prephenate dehydrogenase
AFR_41920	COG2318	DinB family
AFR_41925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFR_41925	COG0235	Class ii aldolase
AFR_41930	COG1796	DNA polymerase
AFR_41930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFR_41945	COG0642	Histidine kinase
AFR_41990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AFR_42035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFR_42050	COG3706	GGDEF domain
AFR_42095	COG2084	Dehydrogenase
AFR_42110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFR_42125	COG0737	Belongs to the 5'-nucleotidase family
AFR_42150	COG1131	(ABC) transporter
AFR_42155	COG1725	Transcriptional regulator
AFR_42190	COG0242	peptide deformylase activity
AFR_42210	COG1881	PFAM PEBP family protein
AFR_42215	COG5002	protein histidine kinase activity
AFR_42240	COG4941	Belongs to the sigma-70 factor family
AFR_42255	COG2329	Antibiotic biosynthesis monooxygenase
AFR_42305	COG3469	chitinase activity
AFR_42310	COG3321	synthase
AFR_42310	COG1028	Short-chain dehydrogenase reductase Sdr
AFR_42310	COG0604	alcohol dehydrogenase
AFR_42330	COG0789	Transcriptional regulator
AFR_42335	COG3959	Transketolase, thiamine diphosphate binding domain
AFR_42340	COG3958	Transketolase
AFR_42345	COG2801	Transposase and inactivated derivatives
AFR_42345	COG3415	Transposase
AFR_42355	COG0183	Belongs to the thiolase family
AFR_42370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFR_42385	COG0598	Magnesium transport protein CorA
AFR_42390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_42400	COG0371	Dehydrogenase
AFR_42415	COG0438	transferase activity, transferring glycosyl groups
AFR_42420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFR_42425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AFR_42430	COG3275	phosphorelay sensor kinase activity
AFR_42440	COG0745	RESPONSE REGULATOR receiver
AFR_42445	COG2205	protein histidine kinase activity
AFR_42460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFR_42480	COG0180	Tryptophanyl-tRNA synthetase
AFR_42495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFR_42510	COG1316	TRANSCRIPTIONal
AFR_42525	COG5002	protein histidine kinase activity
AFR_42580	COG1764	response to oxidative stress
AFR_42590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFR_42595	COG0561	phosphatase activity
AFR_42600	COG0561	phosphatase activity
AFR_42610	COG1834	amidinotransferase
AFR_42640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFR_42645	COG3540	Alkaline phosphatase
AFR_42665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFR_42675	COG1408	metallophosphoesterase
AFR_42730	COG0315	cyclic pyranopterin monophosphate synthase activity
AFR_42730	COG0521	Mo-molybdopterin cofactor biosynthetic process
AFR_42735	COG0315	cyclic pyranopterin monophosphate synthase activity
AFR_42740	COG5001	Diguanylate cyclase
AFR_42740	COG4251	negative regulation of phosphorylation
AFR_42740	COG3706	GGDEF domain
AFR_42740	COG2203	Gaf domain
AFR_42805	COG0305	Participates in initiation and elongation during chromosome replication
AFR_42815	COG0359	binds to the 23S rRNA
AFR_42820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFR_42830	COG0360	Binds together with S18 to 16S ribosomal RNA
AFR_42860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFR_42870	COG1695	Transcriptional regulator
AFR_42900	COG0617	tRNA 3'-terminal CCA addition
AFR_42915	COG2815	serine threonine protein kinase
AFR_42915	COG0515	serine threonine protein kinase
AFR_42920	COG1595	DNA-templated transcription, initiation
AFR_42930	COG0492	ferredoxin-NADP+ reductase activity
AFR_42935	COG3118	belongs to the thioredoxin family
AFR_42940	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFR_42940	COG3409	Peptidoglycan-binding domain 1 protein
AFR_42950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AFR_42955	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFR_42970	COG1192	Involved in chromosome partitioning
AFR_42975	COG0357	Ribosomal RNA small subunit methyltransferase G
AFR_42985	COG0706	membrane insertase activity
AFR_42990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFR_42995	COG0594	ribonuclease P activity
AFR_43000	COG0230	Belongs to the bacterial ribosomal protein bL34 family