locus-tag	class	description
L3i22_000020	COG0592	DNA-directed DNA polymerase activity
L3i22_000030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L3i22_000040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L3i22_000050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
L3i22_000080	COG0187	DNA topoisomerase II activity
L3i22_000090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3i22_000170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L3i22_000200	COG0442	prolyl-tRNA aminoacylation
L3i22_000230	COG0326	Molecular chaperone. Has ATPase activity
L3i22_000280	COG1960	acyl-CoA dehydrogenase activity
L3i22_000300	COG1846	Transcriptional regulator
L3i22_000310	COG2353	YceI-like domain
L3i22_000390	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L3i22_000400	COG1716	ATPase activity
L3i22_000400	COG1716	ATPase activity
L3i22_000410	COG1716	ATPase activity
L3i22_000440	COG0768	penicillin binding
L3i22_000450	COG0515	serine threonine protein kinase
L3i22_000460	COG0515	serine threonine protein kinase
L3i22_000460	COG2815	serine threonine protein kinase
L3i22_000520	COG2181	nitrate reductase activity
L3i22_000520	COG0247	lactate metabolic process
L3i22_000580	COG0717	Belongs to the dCTP deaminase family
L3i22_000650	COG1960	acyl-CoA dehydrogenase activity
L3i22_000780	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3i22_000790	COG0022	dehydrogenase e1 component
L3i22_000850	COG0443	Heat shock 70 kDa protein
L3i22_000860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L3i22_000870	COG0484	heat shock protein binding
L3i22_000880	COG0789	Transcriptional regulator
L3i22_000920	COG2814	Major facilitator Superfamily
L3i22_000930	COG0542	response to heat
L3i22_000960	COG0640	Transcriptional regulator
L3i22_000980	COG0586	Pfam SNARE associated Golgi protein
L3i22_000990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L3i22_001120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L3i22_001130	COG0151	Belongs to the GarS family
L3i22_001180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L3i22_001190	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L3i22_001200	COG0047	phosphoribosylformylglycinamidine synthase activity
L3i22_001210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L3i22_001250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L3i22_001260	COG0641	radical SAM
L3i22_001290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L3i22_001330	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
L3i22_001420	COG0483	inositol monophosphate 1-phosphatase activity
L3i22_001440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L3i22_001460	COG0142	geranyltranstransferase activity
L3i22_001490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3i22_001500	COG1595	DNA-templated transcription, initiation
L3i22_001510	COG0515	serine threonine protein kinase
L3i22_001580	COG1970	mechanosensitive ion channel activity
L3i22_001600	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_001610	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_001620	COG2172	sigma factor antagonist activity
L3i22_001650	COG0745	RESPONSE REGULATOR receiver
L3i22_001670	COG1136	(ABC) transporter
L3i22_001760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3i22_001770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3i22_001790	COG0784	Response regulator, receiver
L3i22_001790	COG2205	protein histidine kinase activity
L3i22_001800	COG0745	RESPONSE REGULATOR receiver
L3i22_001840	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_001850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L3i22_001860	COG0406	alpha-ribazole phosphatase activity
L3i22_001870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3i22_001890	COG1333	cytochrome c biogenesis protein
L3i22_001900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L3i22_001920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L3i22_001940	COG1595	DNA-templated transcription, initiation
L3i22_001960	COG0163	prenyltransferase activity
L3i22_002010	COG0513	Belongs to the DEAD box helicase family
L3i22_002050	COG3883	PFAM NLP P60 protein
L3i22_002050	COG0791	NLP P60 protein
L3i22_002060	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L3i22_002100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_002110	COG1120	ATPase activity
L3i22_002160	COG3973	AAA domain
L3i22_002200	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L3i22_002220	COG0667	Aldo Keto reductase
L3i22_002230	COG4279	zinc finger
L3i22_002240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L3i22_002270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L3i22_002280	COG2226	methyltransferase
L3i22_002320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_002330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_002340	COG0649	NAD binding
L3i22_002360	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L3i22_002370	COG1034	ATP synthesis coupled electron transport
L3i22_002380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L3i22_002390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_002400	COG0839	Belongs to the complex I subunit 6 family
L3i22_002410	COG0713	ATP synthesis coupled electron transport
L3i22_002440	COG1007	ATP synthesis coupled electron transport
L3i22_002460	COG0142	geranyltranstransferase activity
L3i22_002510	COG1950	PFAM Membrane protein of
L3i22_002570	COG0596	Alpha beta hydrolase
L3i22_002610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L3i22_002730	COG1111	helicase
L3i22_002730	COG1205	dead DEAH box helicase
L3i22_002740	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_002760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L3i22_002790	COG1754	DNA topoisomerase type I activity
L3i22_002790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L3i22_002810	COG1309	transcriptional regulator
L3i22_002830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L3i22_002860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L3i22_002920	COG1774	PSP1 C-terminal conserved region
L3i22_002980	COG0738	Major facilitator superfamily
L3i22_002990	COG0644	oxidoreductase
L3i22_003070	COG0583	DNA-binding transcription factor activity
L3i22_003080	COG0702	epimerase
L3i22_003120	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L3i22_003140	COG1793	dna ligase
L3i22_003140	COG3285	dna ligase
L3i22_003190	COG1061	Type III restriction enzyme res subunit
L3i22_003220	COG0546	phosphoglycolate phosphatase activity
L3i22_003230	COG1278	Cold shock
L3i22_003240	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L3i22_003300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L3i22_003310	COG2814	Major facilitator Superfamily
L3i22_003350	COG2252	PERMEase
L3i22_003360	COG1846	Transcriptional regulator
L3i22_003370	COG2814	Major facilitator Superfamily
L3i22_003410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L3i22_003430	COG0259	pyridoxamine-phosphate oxidase activity
L3i22_003450	COG2017	converts alpha-aldose to the beta-anomer
L3i22_003520	COG3842	ATPase activity
L3i22_003580	COG1134	teichoic acid transport
L3i22_003580	COG1388	LysM domain
L3i22_003610	COG1309	transcriptional regulator
L3i22_003660	COG0477	Major facilitator Superfamily
L3i22_003770	COG3321	synthase
L3i22_003770	COG0604	alcohol dehydrogenase
L3i22_003770	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_003790	COG2197	response regulator
L3i22_003810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L3i22_003820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L3i22_003830	COG3300	MHYT domain
L3i22_003830	COG5001	Diguanylate cyclase
L3i22_003900	COG2119	membrane
L3i22_003910	COG0596	Alpha beta hydrolase
L3i22_003940	COG0477	Major facilitator Superfamily
L3i22_004030	COG0586	Pfam SNARE associated Golgi protein
L3i22_004060	COG0025	NhaP-type Na H and K H
L3i22_004070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L3i22_004180	COG1309	transcriptional regulator
L3i22_004190	COG1131	(ABC) transporter
L3i22_004200	COG3559	Exporter of polyketide antibiotics
L3i22_004230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L3i22_004260	COG3795	YCII-related domain
L3i22_004270	COG4941	Belongs to the sigma-70 factor family
L3i22_004280	COG0840	transmembrane signaling receptor activity
L3i22_004300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L3i22_004310	COG2271	Major facilitator Superfamily
L3i22_004360	COG0303	'Molybdopterin
L3i22_004430	COG1819	glycosyl
L3i22_004450	COG5398	heme oxygenase
L3i22_004490	COG4558	Periplasmic binding protein
L3i22_004500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_004510	COG1120	ATPase activity
L3i22_004530	COG4821	SIS domain
L3i22_004610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3i22_004640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L3i22_004650	COG2188	Transcriptional regulator
L3i22_004670	COG0450	alkyl hydroperoxide reductase
L3i22_004680	COG1252	NADH dehydrogenase
L3i22_004690	COG0488	(ABC) transporter
L3i22_004710	COG1733	regulation of RNA biosynthetic process
L3i22_004720	COG5002	protein histidine kinase activity
L3i22_004730	COG0745	RESPONSE REGULATOR receiver
L3i22_004760	COG1136	(ABC) transporter
L3i22_004770	COG0577	efflux transmembrane transporter activity
L3i22_004770	COG1136	(ABC) transporter
L3i22_004790	COG1595	DNA-templated transcription, initiation
L3i22_004810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L3i22_004810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L3i22_004820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3i22_004940	COG1609	Transcriptional regulator
L3i22_004970	COG2186	Transcriptional regulator
L3i22_005140	COG3979	chitinase
L3i22_005170	COG2409	Drug exporters of the RND superfamily
L3i22_005180	COG0737	Belongs to the 5'-nucleotidase family
L3i22_005180	COG4085	toxin activity
L3i22_005180	COG1525	nuclease
L3i22_005190	COG0583	DNA-binding transcription factor activity
L3i22_005230	COG2770	Histidine kinase
L3i22_005230	COG2208	phosphoserine phosphatase activity
L3i22_005240	COG3268	Saccharopine dehydrogenase
L3i22_005310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L3i22_005320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L3i22_005330	COG2205	protein histidine kinase activity
L3i22_005340	COG0745	RESPONSE REGULATOR receiver
L3i22_005390	COG0745	RESPONSE REGULATOR receiver
L3i22_005400	COG4251	negative regulation of phosphorylation
L3i22_005410	COG0784	Response regulator, receiver
L3i22_005420	COG0483	inositol monophosphate 1-phosphatase activity
L3i22_005430	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_005460	COG0515	serine threonine protein kinase
L3i22_005460	COG2815	serine threonine protein kinase
L3i22_005490	COG0514	ATP-dependent DNA helicase (RecQ)
L3i22_005520	COG1937	Protein conserved in bacteria
L3i22_005530	COG2608	mercury ion transmembrane transporter activity
L3i22_005570	COG0513	Belongs to the DEAD box helicase family
L3i22_005690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L3i22_005700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L3i22_005720	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L3i22_005800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_005860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_005870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L3i22_005880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_005890	COG0839	Belongs to the complex I subunit 6 family
L3i22_005900	COG0713	ATP synthesis coupled electron transport
L3i22_005920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_005930	COG1007	ATP synthesis coupled electron transport
L3i22_005970	COG0501	Belongs to the peptidase M48B family
L3i22_006040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_006110	COG3300	MHYT domain
L3i22_006110	COG5001	Diguanylate cyclase
L3i22_006120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L3i22_006130	COG2030	dehydratase
L3i22_006170	COG0081	regulation of translation
L3i22_006200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L3i22_006220	COG0085	RNA polymerase activity
L3i22_006230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L3i22_006260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L3i22_006270	COG0049	tRNA binding
L3i22_006280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L3i22_006290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L3i22_006300	COG0051	transcription antitermination factor activity, RNA binding
L3i22_006310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L3i22_006320	COG0088	Forms part of the polypeptide exit tunnel
L3i22_006330	COG0089	rRNA binding
L3i22_006340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L3i22_006350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L3i22_006360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L3i22_006370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L3i22_006380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L3i22_006390	COG0255	Belongs to the universal ribosomal protein uL29 family
L3i22_006400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L3i22_006410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L3i22_006420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L3i22_006430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L3i22_006440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L3i22_006450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L3i22_006460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L3i22_006470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L3i22_006480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L3i22_006490	COG1841	ribosomal large subunit assembly
L3i22_006500	COG0200	Binds to the 23S rRNA
L3i22_006520	COG0563	adenylate kinase activity
L3i22_006550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L3i22_006560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L3i22_006570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L3i22_006580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L3i22_006600	COG0203	ribosomal protein L17
L3i22_006610	COG0101	tRNA pseudouridine synthase activity
L3i22_006640	COG0488	(ABC) transporter
L3i22_006650	COG0352	thiamine-phosphate diphosphorylase activity
L3i22_006660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3i22_006660	COG2022	thiamine diphosphate biosynthetic process
L3i22_006680	COG2022	thiamine diphosphate biosynthetic process
L3i22_006690	COG0352	thiamine-phosphate diphosphorylase activity
L3i22_006700	COG0351	phosphomethylpyrimidine kinase
L3i22_006710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L3i22_006770	COG2018	Roadblock/LC7 domain
L3i22_006820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L3i22_006830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L3i22_006840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3i22_006870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L3i22_006900	COG0736	holo-[acyl-carrier-protein] synthase activity
L3i22_006920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L3i22_006940	COG0802	atpase or kinase
L3i22_006950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L3i22_006960	COG1214	PFAM Peptidase M22, glycoprotease
L3i22_006960	COG0456	acetyltransferase
L3i22_006980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L3i22_007000	COG1132	(ABC) transporter
L3i22_007010	COG1132	(ABC) transporter
L3i22_007020	COG0459	protein refolding
L3i22_007030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L3i22_007050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L3i22_007080	COG4214	carbohydrate transport
L3i22_007090	COG1940	carbohydrate kinase activity
L3i22_007150	COG2197	response regulator
L3i22_007180	COG0516	GMP reductase activity
L3i22_007200	COG1316	TRANSCRIPTIONal
L3i22_007220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L3i22_007220	COG0519	Catalyzes the synthesis of GMP from XMP
L3i22_007230	COG1051	belongs to the nudix hydrolase family
L3i22_007240	COG0494	nUDIX hydrolase
L3i22_007250	COG1183	phosphatidylcholine synthase activity
L3i22_007270	COG4941	Belongs to the sigma-70 factor family
L3i22_007280	COG0688	phosphatidylethanolamine metabolic process
L3i22_007330	COG4166	transmembrane transport
L3i22_007340	COG0601	transmembrane transport
L3i22_007350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_007360	COG0444	Belongs to the ABC transporter superfamily
L3i22_007370	COG4608	Belongs to the ABC transporter superfamily
L3i22_007380	COG1605	Chorismate mutase
L3i22_007400	COG4085	toxin activity
L3i22_007400	COG1525	nuclease
L3i22_007400	COG0737	Belongs to the 5'-nucleotidase family
L3i22_007420	COG0739	heme binding
L3i22_007430	COG0739	heme binding
L3i22_007450	COG0045	succinate-CoA ligase (ADP-forming) activity
L3i22_007490	COG0138	bifunctional purine biosynthesis protein purh
L3i22_007540	COG0538	isocitrate dehydrogenase activity
L3i22_007560	COG1349	DNA-binding transcription factor activity
L3i22_007590	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L3i22_007720	COG0489	protein tyrosine kinase activity
L3i22_007720	COG3206	protein involved in exopolysaccharide biosynthesis
L3i22_007730	COG0529	Catalyzes the synthesis of activated sulfate
L3i22_007750	COG1131	(ABC) transporter
L3i22_007820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L3i22_007840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L3i22_007840	COG1024	Enoyl-CoA hydratase
L3i22_007900	COG0148	phosphopyruvate hydratase activity
L3i22_007930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L3i22_007990	COG0714	Associated with various cellular activities
L3i22_008060	COG0183	Belongs to the thiolase family
L3i22_008070	COG2755	lipolytic protein G-D-S-L family
L3i22_008110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3i22_008150	COG1234	tRNA 3'-trailer cleavage
L3i22_008160	COG2326	polyphosphate kinase activity
L3i22_008200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3i22_008240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L3i22_008260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L3i22_008280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L3i22_008310	COG1331	Highly conserved protein containing a thioredoxin domain
L3i22_008420	COG3629	intracellular signal transduction
L3i22_008420	COG3903	Transcriptional regulator
L3i22_008470	COG1674	ftsk spoiiie
L3i22_008560	COG2197	response regulator
L3i22_008570	COG0823	Involved in the tonB-independent uptake of proteins
L3i22_008590	COG0464	growth
L3i22_008800	COG3629	intracellular signal transduction
L3i22_008800	COG3903	Transcriptional regulator
L3i22_008830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L3i22_008880	COG1609	Transcriptional regulator
L3i22_008920	COG1473	amidohydrolase
L3i22_008930	COG2814	Major facilitator Superfamily
L3i22_008960	COG0626	cystathionine gamma-synthase activity
L3i22_008970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_009000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L3i22_009020	COG0438	transferase activity, transferring glycosyl groups
L3i22_009060	COG0778	Nitroreductase
L3i22_009060	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
L3i22_009070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L3i22_009090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L3i22_009160	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_009180	COG1515	deoxyribonuclease V activity
L3i22_009190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3i22_009200	COG2835	tetraacyldisaccharide 4'-kinase activity
L3i22_009260	COG0745	RESPONSE REGULATOR receiver
L3i22_009270	COG5002	protein histidine kinase activity
L3i22_009270	COG5000	phosphorelay sensor kinase activity
L3i22_009290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3i22_009300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L3i22_009320	COG0653	protein targeting
L3i22_009390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L3i22_009400	COG2884	Cell division ATP-binding protein ftsE
L3i22_009410	COG2177	Part of the ABC transporter FtsEX involved in
L3i22_009420	COG1196	nuclear chromosome segregation
L3i22_009420	COG0741	lytic transglycosylase activity
L3i22_009420	COG0739	heme binding
L3i22_009430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L3i22_009460	COG2161	toxin-antitoxin pair type II binding
L3i22_009470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L3i22_009480	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L3i22_009510	COG1678	Uncharacterized ACR, COG1678
L3i22_009520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L3i22_009690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3i22_009720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_009760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L3i22_009780	COG1459	type II secretion system
L3i22_009800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L3i22_009830	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_010010	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L3i22_010020	COG2199	diguanylate cyclase activity
L3i22_010020	COG2200	EAL domain
L3i22_010020	COG2203	Gaf domain
L3i22_010060	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
L3i22_010070	COG1793	dna ligase
L3i22_010070	COG3285	dna ligase
L3i22_010080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_010090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L3i22_010140	COG1335	isochorismatase
L3i22_010150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L3i22_010220	COG1234	tRNA 3'-trailer cleavage
L3i22_010230	COG0438	transferase activity, transferring glycosyl groups
L3i22_010240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L3i22_010250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L3i22_010280	COG1228	amidohydrolase
L3i22_010300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3i22_010310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L3i22_010340	COG0789	Transcriptional regulator
L3i22_010360	COG1131	(ABC) transporter
L3i22_010380	COG4585	Histidine kinase
L3i22_010390	COG2197	response regulator
L3i22_010440	COG0633	Ferredoxin
L3i22_010440	COG3217	Mosc domain protein beta barrel domain protein
L3i22_010480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L3i22_010480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L3i22_010540	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L3i22_010550	COG5297	Belongs to the glycosyl hydrolase family 6
L3i22_010600	COG1376	ErfK ybiS ycfS ynhG family protein
L3i22_010610	COG1376	ErfK ybiS ycfS ynhG family protein
L3i22_010660	COG1175	transmembrane transport
L3i22_010670	COG3833	ABC-type maltose transport systems, permease component
L3i22_010710	COG0431	NADPH-dependent FMN reductase
L3i22_010750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_010760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_010770	COG2197	response regulator
L3i22_010780	COG4585	Histidine kinase
L3i22_010800	COG2124	cytochrome p450
L3i22_010820	COG2255	four-way junction helicase activity
L3i22_010860	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_010890	COG3706	GGDEF domain
L3i22_011020	COG1940	carbohydrate kinase activity
L3i22_011020	COG1846	Transcriptional regulator
L3i22_011040	COG4209	transmembrane transport
L3i22_011050	COG0395	ABC-type sugar transport system, permease component
L3i22_011130	COG0277	FAD linked oxidase domain protein
L3i22_011150	COG0745	RESPONSE REGULATOR receiver
L3i22_011260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_011340	COG3850	Histidine kinase
L3i22_011340	COG5002	protein histidine kinase activity
L3i22_011410	COG1609	Transcriptional regulator
L3i22_011440	COG2706	6-phosphogluconolactonase activity
L3i22_011460	COG1940	carbohydrate kinase activity
L3i22_011480	COG1070	Carbohydrate kinase
L3i22_011490	COG0438	transferase activity, transferring glycosyl groups
L3i22_011510	COG0366	Alpha amylase catalytic
L3i22_011520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L3i22_011580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L3i22_011760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L3i22_011770	COG2205	protein histidine kinase activity
L3i22_011780	COG0745	RESPONSE REGULATOR receiver
L3i22_011810	COG1136	(ABC) transporter
L3i22_011820	COG0577	efflux transmembrane transporter activity
L3i22_011870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L3i22_011880	COG1492	cobalamin metabolic process
L3i22_011890	COG0501	Belongs to the peptidase M48B family
L3i22_011930	COG1793	dna ligase
L3i22_011960	COG1797	cobyrinic acid a,c-diamide synthase activity
L3i22_012000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L3i22_012010	COG1648	precorrin-2 dehydrogenase activity
L3i22_012010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L3i22_012020	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L3i22_012110	COG0668	transmembrane transport
L3i22_012160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L3i22_012190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L3i22_012240	COG4552	Acetyltransferase involved in intracellular survival and related
L3i22_012290	COG1335	isochorismatase
L3i22_012300	COG1802	Transcriptional regulator
L3i22_012320	COG0640	Transcriptional regulator
L3i22_012360	COG0714	Associated with various cellular activities
L3i22_012370	COG3864	Putative metallopeptidase domain
L3i22_012460	COG2188	Transcriptional regulator
L3i22_012570	COG0544	peptidyl-prolyl cis-trans isomerase activity
L3i22_012580	COG0740	serine-type endopeptidase activity
L3i22_012590	COG0740	serine-type endopeptidase activity
L3i22_012600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L3i22_012650	COG0525	valine-tRNA ligase activity
L3i22_012660	COG0285	dihydrofolate synthase activity
L3i22_012690	COG0105	UTP biosynthetic process
L3i22_012720	COG1131	(ABC) transporter
L3i22_012750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L3i22_012780	COG0596	Alpha beta hydrolase
L3i22_012790	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_012790	COG2172	sigma factor antagonist activity
L3i22_012790	COG2208	phosphoserine phosphatase activity
L3i22_012830	COG1530	ribonuclease E activity
L3i22_012850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L3i22_012860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L3i22_012870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L3i22_012880	COG0454	-acetyltransferase
L3i22_012890	COG0180	Tryptophanyl-tRNA synthetase
L3i22_012920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L3i22_012940	COG0406	alpha-ribazole phosphatase activity
L3i22_012960	COG1307	EDD domain protein, DegV family
L3i22_012980	COG2890	protein-(glutamine-N5) methyltransferase activity
L3i22_013010	COG2333	competence protein COMEC
L3i22_013010	COG0658	competence protein
L3i22_013050	COG0268	Binds directly to 16S ribosomal RNA
L3i22_013090	COG0481	GTPase activity
L3i22_013100	COG2261	transglycosylase associated protein
L3i22_013150	COG1420	regulation of RNA biosynthetic process
L3i22_013160	COG0484	heat shock protein binding
L3i22_013170	COG1309	transcriptional regulator
L3i22_013180	COG0596	Alpha beta hydrolase
L3i22_013210	COG0537	adenosine 5'-monophosphoramidase activity
L3i22_013250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L3i22_013280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L3i22_013310	COG1381	Involved in DNA repair and RecF pathway recombination
L3i22_013320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L3i22_013360	COG0667	Aldo Keto reductase
L3i22_013440	COG4172	Belongs to the ABC transporter superfamily
L3i22_013460	COG0596	Alpha beta hydrolase
L3i22_013510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L3i22_013520	COG1121	(ABC) transporter
L3i22_013530	COG3443	Belongs to the bacterial solute-binding protein 9 family
L3i22_013530	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3i22_013570	COG0423	glycine-tRNA ligase activity
L3i22_013590	COG3608	succinylglutamate desuccinylase aspartoacylase
L3i22_013590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L3i22_013630	COG4260	virion core protein, lumpy skin disease virus
L3i22_013660	COG2018	Roadblock/LC7 domain
L3i22_013710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L3i22_013720	COG0358	DNA primase activity
L3i22_013740	COG1131	(ABC) transporter
L3i22_013770	COG1295	ribonuclease BN
L3i22_013820	COG4974	Belongs to the 'phage' integrase family
L3i22_013870	COG3311	Transcriptional regulator
L3i22_013880	COG1569	PIN domain
L3i22_013910	COG4115	mRNA cleavage
L3i22_013920	COG2161	toxin-antitoxin pair type II binding
L3i22_014110	COG3693	PFAM glycoside hydrolase, family 10
L3i22_014110	COG2382	esterase
L3i22_014240	COG1309	transcriptional regulator
L3i22_014290	COG3401	FG-GAP repeat protein
L3i22_014380	COG0018	arginyl-trna synthetase
L3i22_014390	COG0737	Belongs to the 5'-nucleotidase family
L3i22_014420	COG0515	serine threonine protein kinase
L3i22_014460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L3i22_014470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L3i22_014470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L3i22_014490	COG3973	AAA domain
L3i22_014540	COG1472	Belongs to the glycosyl hydrolase 3 family
L3i22_014560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3i22_014570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L3i22_014640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L3i22_014670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L3i22_014680	COG0432	Pfam Uncharacterised protein family UPF0047
L3i22_014780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L3i22_014870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L3i22_014880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L3i22_014910	COG2226	methyltransferase
L3i22_014960	COG0557	exoribonuclease II activity
L3i22_014970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L3i22_014980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L3i22_014980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L3i22_014990	COG0174	glutamine synthetase
L3i22_015010	COG1595	DNA-templated transcription, initiation
L3i22_015020	COG3766	membrane
L3i22_015090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L3i22_015100	COG1846	Transcriptional regulator
L3i22_015140	COG1051	belongs to the nudix hydrolase family
L3i22_015280	COG0438	transferase activity, transferring glycosyl groups
L3i22_015420	COG1674	ftsk spoiiie
L3i22_015490	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L3i22_015490	COG1672	PFAM Archaeal ATPase
L3i22_015520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L3i22_015530	COG0017	Asparaginyl-tRNA synthetase
L3i22_015550	COG0321	lipoyl(octanoyl) transferase activity
L3i22_015580	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3i22_015590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3i22_015610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L3i22_015620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L3i22_015630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L3i22_015640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L3i22_015660	COG1994	Peptidase M50
L3i22_015670	COG0667	Aldo Keto reductase
L3i22_015730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L3i22_015750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L3i22_015790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L3i22_015800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L3i22_015810	COG1929	Belongs to the glycerate kinase type-1 family
L3i22_015830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L3i22_015850	COG0425	Belongs to the sulfur carrier protein TusA family
L3i22_015860	COG1104	cysteine desulfurase activity
L3i22_015870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L3i22_015900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L3i22_015980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L3i22_016010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L3i22_016030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L3i22_016070	COG0501	Belongs to the peptidase M48B family
L3i22_016080	COG0438	transferase activity, transferring glycosyl groups
L3i22_016100	COG1132	(ABC) transporter
L3i22_016160	COG2197	response regulator
L3i22_016200	COG1940	carbohydrate kinase activity
L3i22_016220	COG2072	flavoprotein involved in K transport
L3i22_016330	COG2211	Major facilitator Superfamily
L3i22_016350	COG0205	6-phosphofructokinase activity
L3i22_016360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L3i22_016380	COG0386	Belongs to the glutathione peroxidase family
L3i22_016400	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L3i22_016440	COG0504	CTP synthase activity
L3i22_016450	COG0583	DNA-binding transcription factor activity
L3i22_016470	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L3i22_016480	COG2815	serine threonine protein kinase
L3i22_016480	COG0515	serine threonine protein kinase
L3i22_016530	COG0142	geranyltranstransferase activity
L3i22_016710	COG1309	transcriptional regulator
L3i22_016730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L3i22_016740	COG1053	succinate dehydrogenase
L3i22_016770	COG2226	methyltransferase
L3i22_016790	COG1233	COG1233 Phytoene dehydrogenase and related
L3i22_016910	COG0587	DNA-directed DNA polymerase activity
L3i22_016930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L3i22_016980	COG0714	Associated with various cellular activities
L3i22_016990	COG0495	leucyl-tRNA aminoacylation
L3i22_017010	COG3442	glutamine amidotransferase
L3i22_017040	COG2001	Belongs to the MraZ family
L3i22_017050	COG0275	rRNA processing
L3i22_017070	COG0768	penicillin binding
L3i22_017080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L3i22_017100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L3i22_017130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L3i22_017140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L3i22_017150	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L3i22_017160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L3i22_017170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L3i22_017180	COG1799	cell septum assembly
L3i22_017200	COG3599	regulation of cell shape
L3i22_017240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L3i22_017280	COG0587	DNA-directed DNA polymerase activity
L3i22_017300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L3i22_017320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L3i22_017330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L3i22_017340	COG0131	Imidazoleglycerol-phosphate dehydratase
L3i22_017350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L3i22_017370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L3i22_017390	COG0107	imidazoleglycerol-phosphate synthase activity
L3i22_017420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_017440	COG1022	Amp-dependent synthetase and ligase
L3i22_017450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L3i22_017510	COG1132	(ABC) transporter
L3i22_017520	COG1132	(ABC) transporter
L3i22_017530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L3i22_017560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L3i22_017620	COG0159	tryptophan synthase activity
L3i22_017640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L3i22_017650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_017670	COG0067	glutamate synthase
L3i22_017670	COG0069	glutamate synthase activity
L3i22_017670	COG0070	glutamate synthase
L3i22_017730	COG0559	Belongs to the binding-protein-dependent transport system permease family
L3i22_017780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3i22_017790	COG0765	amino acid transport
L3i22_017830	COG2226	methyltransferase
L3i22_017840	COG0539	negative regulation of cytoplasmic translation
L3i22_017850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L3i22_017850	COG0237	dephospho-CoA kinase activity
L3i22_017910	COG1217	gtp-binding protein TYPA
L3i22_017930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L3i22_017940	COG0740	serine-type endopeptidase activity
L3i22_017960	COG0515	serine threonine protein kinase
L3i22_017970	COG2755	lipolytic protein G-D-S-L family
L3i22_017980	COG1953	Uracil, thiamine, allantoin
L3i22_018030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_018050	COG1162	GTPase activity
L3i22_018070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L3i22_018090	COG0322	excinuclease ABC activity
L3i22_018100	COG1660	Displays ATPase and GTPase activities
L3i22_018120	COG1481	regulation of sporulation
L3i22_018130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L3i22_018140	COG0126	phosphoglycerate kinase activity
L3i22_018150	COG0149	triose-phosphate isomerase activity
L3i22_018170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L3i22_018210	COG0363	glucosamine-6-phosphate deaminase activity
L3i22_018240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L3i22_018260	COG0109	protoheme IX farnesyltransferase activity
L3i22_018340	COG0396	ATPase activity
L3i22_018350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L3i22_018360	COG0822	iron-sulfur transferase activity
L3i22_018370	COG2151	metal-sulfur cluster biosynthetic enzyme
L3i22_018410	COG2267	carboxylic ester hydrolase activity
L3i22_018500	COG0488	(ABC) transporter
L3i22_018530	COG1024	Enoyl-CoA hydratase
L3i22_018540	COG1132	(ABC) transporter
L3i22_018560	COG3663	DNA glycosylase
L3i22_018620	COG1309	transcriptional regulator
L3i22_018660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L3i22_018720	COG0006	proline dipeptidase activity
L3i22_018790	COG0714	Associated with various cellular activities
L3i22_018810	COG2304	oxidoreductase activity
L3i22_018820	COG2197	response regulator
L3i22_018830	COG4585	Histidine kinase
L3i22_018850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L3i22_018860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L3i22_018980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_019080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L3i22_019080	COG0543	2 iron, 2 sulfur cluster binding
L3i22_019100	COG1365	unkown
L3i22_019110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L3i22_019140	COG2182	Extracellular solute-binding protein
L3i22_019150	COG1175	transmembrane transport
L3i22_019160	COG0395	ABC-type sugar transport system, permease component
L3i22_019170	COG1653	transport
L3i22_019180	COG1175	transmembrane transport
L3i22_019190	COG0395	ABC-type sugar transport system, permease component
L3i22_019200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3i22_019200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3i22_019220	COG3265	gluconokinase activity
L3i22_019260	COG2197	response regulator
L3i22_019420	COG3304	Inner membrane component domain
L3i22_019500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L3i22_019500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L3i22_019510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L3i22_019530	COG1309	transcriptional regulator
L3i22_019550	COG1309	transcriptional regulator
L3i22_019590	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_019610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L3i22_019620	COG0515	serine threonine protein kinase
L3i22_019690	COG2133	pyrroloquinoline quinone binding
L3i22_019710	COG2205	protein histidine kinase activity
L3i22_019720	COG5634	Uncharacterized conserved protein (DUF2278)
L3i22_019780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L3i22_019790	COG1253	flavin adenine dinucleotide binding
L3i22_019810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L3i22_019830	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L3i22_019860	COG0840	transmembrane signaling receptor activity
L3i22_019910	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_019950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L3i22_019960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_019970	COG1116	anion transmembrane transporter activity
L3i22_019990	COG2897	thiosulfate sulfurtransferase activity
L3i22_020010	COG0572	uridine kinase
L3i22_020030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L3i22_020060	COG1175	transmembrane transport
L3i22_020100	COG1017	nitric oxide dioxygenase activity
L3i22_020100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L3i22_020110	COG1959	2 iron, 2 sulfur cluster binding
L3i22_020120	COG2205	protein histidine kinase activity
L3i22_020130	COG5002	protein histidine kinase activity
L3i22_020150	COG0604	alcohol dehydrogenase
L3i22_020170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3i22_020170	COG2205	protein histidine kinase activity
L3i22_020220	COG5002	protein histidine kinase activity
L3i22_020230	COG4251	negative regulation of phosphorylation
L3i22_020260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L3i22_020280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L3i22_020300	COG0667	Aldo Keto reductase
L3i22_020310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L3i22_020390	COG5002	protein histidine kinase activity
L3i22_020470	COG0745	RESPONSE REGULATOR receiver
L3i22_020490	COG1129	ABC transporter
L3i22_020500	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_020510	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_020550	COG2267	carboxylic ester hydrolase activity
L3i22_020580	COG0387	Pfam Sodium calcium exchanger
L3i22_020640	COG0463	Glycosyl transferase, family 2
L3i22_020740	COG3655	Transcriptional regulator
L3i22_020770	COG2205	protein histidine kinase activity
L3i22_020780	COG0745	RESPONSE REGULATOR receiver
L3i22_020820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_020860	COG0789	Transcriptional regulator
L3i22_020980	COG2815	serine threonine protein kinase
L3i22_020980	COG0515	serine threonine protein kinase
L3i22_021000	COG1714	RDD family
L3i22_021020	COG0181	hydroxymethylbilane synthase activity
L3i22_021130	COG0628	permease
L3i22_021140	COG0436	Aminotransferase
L3i22_021170	COG1874	Beta-galactosidase
L3i22_021170	COG0366	Alpha amylase catalytic
L3i22_021200	COG5002	protein histidine kinase activity
L3i22_021220	COG0840	transmembrane signaling receptor activity
L3i22_021250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L3i22_021260	COG0726	polysaccharide deacetylase
L3i22_021350	COG1090	epimerase
L3i22_021440	COG2755	lipolytic protein G-D-S-L family
L3i22_021470	COG3599	regulation of cell shape
L3i22_021600	COG0395	ABC-type sugar transport system, permease component
L3i22_021610	COG1175	transmembrane transport
L3i22_021630	COG3119	arylsulfatase activity
L3i22_021660	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_021680	COG1672	PFAM Archaeal ATPase
L3i22_021680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L3i22_021700	COG3903	Transcriptional regulator
L3i22_021700	COG3629	intracellular signal transduction
L3i22_021790	COG2271	Major facilitator Superfamily
L3i22_021800	COG0840	transmembrane signaling receptor activity
L3i22_021930	COG1175	transmembrane transport
L3i22_021940	COG0395	ABC-type sugar transport system, permease component
L3i22_021960	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L3i22_021970	COG3718	enzyme involved in inositol metabolism
L3i22_021980	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_022010	COG1404	Belongs to the peptidase S8 family
L3i22_022020	COG5001	Diguanylate cyclase
L3i22_022030	COG0741	lytic transglycosylase activity
L3i22_022030	COG0739	heme binding
L3i22_022030	COG1196	nuclear chromosome segregation
L3i22_022050	COG2197	response regulator
L3i22_022130	COG0243	molybdopterin cofactor binding
L3i22_022170	COG1024	Enoyl-CoA hydratase
L3i22_022170	COG1250	3-hydroxyacyl-CoA dehydrogenase
L3i22_022180	COG0183	Belongs to the thiolase family
L3i22_022210	COG0438	transferase activity, transferring glycosyl groups
L3i22_022260	COG1802	Transcriptional regulator
L3i22_022300	COG1725	Transcriptional regulator
L3i22_022330	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L3i22_022340	COG0714	Associated with various cellular activities
L3i22_022400	COG0439	Biotin carboxylase
L3i22_022490	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L3i22_022520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_022530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L3i22_022660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L3i22_022700	COG2319	Wd-40 repeat
L3i22_022700	COG4249	Peptidase C14 caspase catalytic subunit p20
L3i22_022780	COG2193	ferroxidase activity
L3i22_022800	COG2885	chlorophyll binding
L3i22_022850	COG4221	oxidoreductase activity
L3i22_022860	COG1309	transcriptional regulator
L3i22_022900	COG1175	transmembrane transport
L3i22_022910	COG0395	ABC-type sugar transport system, permease component
L3i22_022920	COG1486	melibiose metabolic process
L3i22_022980	COG0726	polysaccharide deacetylase
L3i22_023010	COG2936	dipeptidyl-peptidase activity
L3i22_023100	COG1674	ftsk spoiiie
L3i22_023240	COG1674	ftsk spoiiie
L3i22_023280	COG0464	growth
L3i22_023300	COG0596	Alpha beta hydrolase
L3i22_023310	COG3629	intracellular signal transduction
L3i22_023400	COG2197	response regulator
L3i22_023420	COG3629	intracellular signal transduction
L3i22_023420	COG3903	Transcriptional regulator
L3i22_023430	COG3629	intracellular signal transduction
L3i22_023430	COG3903	Transcriptional regulator
L3i22_023440	COG0542	response to heat
L3i22_023450	COG2197	response regulator
L3i22_023460	COG3629	intracellular signal transduction
L3i22_023480	COG1960	acyl-CoA dehydrogenase activity
L3i22_023500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L3i22_023520	COG1309	transcriptional regulator
L3i22_023530	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_023560	COG1309	transcriptional regulator
L3i22_023680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3i22_023750	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L3i22_023770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L3i22_023780	COG2226	methyltransferase
L3i22_023840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L3i22_024020	COG0116	Belongs to the methyltransferase superfamily
L3i22_024020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L3i22_024140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L3i22_024320	COG0443	Heat shock 70 kDa protein
L3i22_024360	COG0714	Associated with various cellular activities
L3i22_024470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L3i22_024480	COG5001	Diguanylate cyclase
L3i22_024490	COG3537	Alpha-1,2-mannosidase
L3i22_024720	COG1595	DNA-templated transcription, initiation
L3i22_024730	COG1252	NADH dehydrogenase
L3i22_024810	COG1609	Transcriptional regulator
L3i22_024850	COG0477	Major facilitator Superfamily
L3i22_024880	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_024880	COG3347	Dehydrogenase
L3i22_024890	COG1070	Carbohydrate kinase
L3i22_024900	COG0247	lactate metabolic process
L3i22_024910	COG1139	Iron-sulfur cluster binding protein
L3i22_024920	COG1556	Lactate utilization protein
L3i22_024930	COG0784	Response regulator, receiver
L3i22_024930	COG5002	protein histidine kinase activity
L3i22_024930	COG2198	Histidine kinase
L3i22_024950	COG0745	RESPONSE REGULATOR receiver
L3i22_024960	COG3852	Histidine kinase
L3i22_025000	COG1136	(ABC) transporter
L3i22_025000	COG0577	efflux transmembrane transporter activity
L3i22_025010	COG0577	efflux transmembrane transporter activity
L3i22_025010	COG1136	(ABC) transporter
L3i22_025040	COG2409	Drug exporters of the RND superfamily
L3i22_025060	COG2205	protein histidine kinase activity
L3i22_025070	COG0745	RESPONSE REGULATOR receiver
L3i22_025130	COG4948	Mandelate Racemase Muconate Lactonizing
L3i22_025190	COG2814	Major facilitator Superfamily
L3i22_025210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L3i22_025260	COG0531	amino acid
L3i22_025360	COG0596	Alpha beta hydrolase
L3i22_025390	COG1116	anion transmembrane transporter activity
L3i22_025400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_025410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_025420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L3i22_025430	COG1414	Transcriptional regulator
L3i22_025480	COG0395	ABC-type sugar transport system, permease component
L3i22_025490	COG1175	transmembrane transport
L3i22_025510	COG1609	Transcriptional regulator
L3i22_025520	COG2936	dipeptidyl-peptidase activity
L3i22_025560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3i22_025600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L3i22_025610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L3i22_025630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L3i22_025720	COG1414	Transcriptional regulator
L3i22_025730	COG3485	protocatechuate 3,4-dioxygenase
L3i22_025740	COG3485	protocatechuate 3,4-dioxygenase
L3i22_025760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L3i22_025780	COG5001	Diguanylate cyclase
L3i22_025780	COG3300	MHYT domain
L3i22_025850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_025870	COG0179	Fumarylacetoacetate (FAA) hydrolase
L3i22_025880	COG0823	Involved in the tonB-independent uptake of proteins
L3i22_025880	COG1506	peptidase
L3i22_025920	COG2197	response regulator
L3i22_026000	COG0039	L-malate dehydrogenase activity
L3i22_026040	COG1116	anion transmembrane transporter activity
L3i22_026050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_026070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_026300	COG1396	sequence-specific DNA binding
L3i22_026410	COG1960	acyl-CoA dehydrogenase activity
L3i22_026430	COG1960	acyl-CoA dehydrogenase activity
L3i22_026440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L3i22_026510	COG0446	pyridine nucleotide-disulphide oxidoreductase
L3i22_026520	COG1472	Belongs to the glycosyl hydrolase 3 family
L3i22_026530	COG1609	Transcriptional regulator
L3i22_026550	COG1175	transmembrane transport
L3i22_026560	COG0395	ABC-type sugar transport system, permease component
L3i22_026570	COG1501	Belongs to the glycosyl hydrolase 31 family
L3i22_026630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L3i22_026670	COG1122	ATPase activity
L3i22_026740	COG5002	protein histidine kinase activity
L3i22_026780	COG5002	protein histidine kinase activity
L3i22_026790	COG2204	response regulator
L3i22_026850	COG1129	ABC transporter
L3i22_026860	COG1879	ABC-type sugar transport system periplasmic component
L3i22_026920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_026940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L3i22_026950	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_026960	COG3842	ATPase activity
L3i22_026980	COG1176	ABC-type spermidine putrescine transport system, permease component I
L3i22_026990	COG1177	transmembrane transport
L3i22_027000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3i22_027010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L3i22_027020	COG0789	Transcriptional regulator
L3i22_027040	COG0745	RESPONSE REGULATOR receiver
L3i22_027050	COG4191	Histidine kinase
L3i22_027050	COG0745	RESPONSE REGULATOR receiver
L3i22_027050	COG2205	protein histidine kinase activity
L3i22_027060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3i22_027090	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_027100	COG2208	phosphoserine phosphatase activity
L3i22_027110	COG1472	Belongs to the glycosyl hydrolase 3 family
L3i22_027130	COG1175	transmembrane transport
L3i22_027150	COG1609	Transcriptional regulator
L3i22_027160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_027230	COG3119	arylsulfatase activity
L3i22_027240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L3i22_027270	COG3191	aminopeptidase activity
L3i22_027310	COG0702	epimerase
L3i22_027320	COG1733	regulation of RNA biosynthetic process
L3i22_027350	COG3706	GGDEF domain
L3i22_027360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L3i22_027370	COG1024	Enoyl-CoA hydratase
L3i22_027370	COG1250	3-hydroxyacyl-CoA dehydrogenase
L3i22_027380	COG0183	Belongs to the thiolase family
L3i22_027390	COG1960	acyl-CoA dehydrogenase activity
L3i22_027420	COG2197	response regulator
L3i22_027430	COG4585	Histidine kinase
L3i22_027470	COG0747	negative chemotaxis
L3i22_027490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_027510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_027520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_027530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_027550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L3i22_027570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_027580	COG0765	amino acid transport
L3i22_027590	COG1126	abc transporter atp-binding protein
L3i22_027600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3i22_027680	COG0667	Aldo Keto reductase
L3i22_027690	COG0596	Alpha beta hydrolase
L3i22_027700	COG1309	transcriptional regulator
L3i22_027710	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L3i22_027730	COG0366	Alpha amylase catalytic
L3i22_027760	COG3237	CsbD-like
L3i22_027780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_027790	COG2409	Drug exporters of the RND superfamily
L3i22_027830	COG1132	(ABC) transporter
L3i22_027840	COG2226	methyltransferase
L3i22_027860	COG0372	Belongs to the citrate synthase family
L3i22_027990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L3i22_028010	COG2223	nitrite transmembrane transporter activity
L3i22_028040	COG1131	(ABC) transporter
L3i22_028080	COG1136	(ABC) transporter
L3i22_028090	COG0577	efflux transmembrane transporter activity
L3i22_028090	COG1136	(ABC) transporter
L3i22_028100	COG0395	ABC-type sugar transport system, permease component
L3i22_028110	COG1175	transmembrane transport
L3i22_028120	COG1653	transport
L3i22_028130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L3i22_028160	COG4733	cellulase activity
L3i22_028160	COG5297	Belongs to the glycosyl hydrolase family 6
L3i22_028190	COG0009	L-threonylcarbamoyladenylate synthase
L3i22_028200	COG2084	Dehydrogenase
L3i22_028240	COG1725	Transcriptional regulator
L3i22_028250	COG1131	(ABC) transporter
L3i22_028270	COG4213	ABC transporter substrate-binding protein
L3i22_028290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L3i22_028310	COG2409	Drug exporters of the RND superfamily
L3i22_028350	COG1414	Transcriptional regulator
L3i22_028390	COG0247	lactate metabolic process
L3i22_028400	COG0277	FAD linked oxidase domain protein
L3i22_028410	COG0277	FAD linked oxidase domain protein
L3i22_028430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L3i22_028430	COG0574	Belongs to the PEP-utilizing enzyme family
L3i22_028440	COG2764	glyoxalase bleomycin resistance protein dioxygenase
L3i22_028460	COG0514	ATP-dependent DNA helicase (RecQ)
L3i22_028480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3i22_028510	COG4106	trans-aconitate 2-methyltransferase activity
L3i22_028520	COG0297	glycogen (starch) synthase activity
L3i22_028560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L3i22_028620	COG2233	PERMEase
L3i22_028630	COG0326	Molecular chaperone. Has ATPase activity
L3i22_028670	COG0477	Major facilitator Superfamily
L3i22_028680	COG1309	transcriptional regulator
L3i22_028700	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_028730	COG2197	response regulator
L3i22_028740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L3i22_028830	COG0477	Major facilitator Superfamily
L3i22_028870	COG1247	-acetyltransferase
L3i22_028890	COG4988	ABC transporter
L3i22_028900	COG1294	oxidase, subunit
L3i22_028910	COG1271	oxidase subunit
L3i22_028930	COG0501	Belongs to the peptidase M48B family
L3i22_028940	COG0791	NLP P60 protein
L3i22_028950	COG1846	Transcriptional regulator
L3i22_028960	COG0596	Alpha beta hydrolase
L3i22_028970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3i22_029020	COG1309	transcriptional regulator
L3i22_029030	COG2188	Transcriptional regulator
L3i22_029040	COG0159	tryptophan synthase activity
L3i22_029080	COG0745	RESPONSE REGULATOR receiver
L3i22_029160	COG4214	carbohydrate transport
L3i22_029190	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_029240	COG3706	GGDEF domain
L3i22_029280	COG5002	protein histidine kinase activity
L3i22_029290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L3i22_029300	COG4988	ABC transporter
L3i22_029310	COG1294	oxidase, subunit
L3i22_029320	COG1271	oxidase subunit
L3i22_029340	COG2080	2 iron, 2 sulfur cluster binding
L3i22_029340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L3i22_029350	COG1620	l-lactate permease
L3i22_029450	COG1131	(ABC) transporter
L3i22_029470	COG2197	response regulator
L3i22_029520	COG1309	transcriptional regulator
L3i22_029580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L3i22_029580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L3i22_029590	COG0166	Belongs to the GPI family
L3i22_029660	COG0515	serine threonine protein kinase
L3i22_029690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_029740	COG1309	transcriptional regulator
L3i22_029760	COG2076	Multidrug Resistance protein
L3i22_029870	COG0601	transmembrane transport
L3i22_029880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_029890	COG0444	Belongs to the ABC transporter superfamily
L3i22_029900	COG4608	Belongs to the ABC transporter superfamily
L3i22_029970	COG1940	carbohydrate kinase activity
L3i22_030040	COG0588	phosphoglycerate mutase activity
L3i22_030050	COG1609	Transcriptional regulator
L3i22_030070	COG2197	response regulator
L3i22_030130	COG0745	RESPONSE REGULATOR receiver
L3i22_030140	COG2205	protein histidine kinase activity
L3i22_030150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L3i22_030160	COG1136	(ABC) transporter
L3i22_030170	COG1136	(ABC) transporter
L3i22_030170	COG0577	efflux transmembrane transporter activity
L3i22_030230	COG3384	dioxygenase
L3i22_030280	COG3718	enzyme involved in inositol metabolism
L3i22_030290	COG3962	Belongs to the TPP enzyme family
L3i22_030300	COG1082	Xylose isomerase domain protein TIM barrel
L3i22_030340	COG0673	inositol 2-dehydrogenase activity
L3i22_030370	COG3396	Phenylacetate-CoA oxygenase
L3i22_030380	COG3460	Phenylacetate-CoA oxygenase
L3i22_030390	COG3396	Phenylacetate-CoA oxygenase
L3i22_030400	COG2151	metal-sulfur cluster biosynthetic enzyme
L3i22_030410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L3i22_030450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_030470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3i22_030480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_030520	COG1408	metallophosphoesterase
L3i22_030530	COG1072	(Pantothenic acid kinase))
L3i22_030580	COG0515	serine threonine protein kinase
L3i22_030600	COG0531	amino acid
L3i22_030630	COG2124	cytochrome p450
L3i22_030650	COG1181	Belongs to the D-alanine--D-alanine ligase family
L3i22_030680	COG4251	negative regulation of phosphorylation
L3i22_030720	COG1063	alcohol dehydrogenase
L3i22_030730	COG5001	Diguanylate cyclase
L3i22_030730	COG3300	MHYT domain
L3i22_030740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L3i22_030750	COG4279	zinc finger
L3i22_030780	COG2409	Drug exporters of the RND superfamily
L3i22_030810	COG3022	response to hydroperoxide
L3i22_030820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_030860	COG1476	TRANSCRIPTIONal
L3i22_030940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L3i22_030980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3i22_031000	COG0494	nUDIX hydrolase
L3i22_031110	COG2346	COG2346, Truncated hemoglobins
L3i22_031150	COG0789	Transcriptional regulator
L3i22_031160	COG1801	Protein of unknown function DUF72
L3i22_031180	COG1621	beta-fructofuranosidase activity
L3i22_031200	COG0577	efflux transmembrane transporter activity
L3i22_031200	COG1136	(ABC) transporter
L3i22_031220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3i22_031250	COG1595	DNA-templated transcription, initiation
L3i22_031280	COG3540	Alkaline phosphatase
L3i22_031360	COG0110	maltose O-acetyltransferase activity
L3i22_031370	COG3226	Transcriptional regulator
L3i22_031380	COG3142	Participates in the control of copper homeostasis
L3i22_031420	COG3706	GGDEF domain
L3i22_031470	COG3511	phospholipase C
L3i22_031540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3i22_031580	COG4249	Peptidase C14 caspase catalytic subunit p20
L3i22_031580	COG2319	Wd-40 repeat
L3i22_031600	COG0667	Aldo Keto reductase
L3i22_031620	COG1136	(ABC) transporter
L3i22_031630	COG4585	Histidine kinase
L3i22_031640	COG2197	response regulator
L3i22_031660	COG1960	acyl-CoA dehydrogenase activity
L3i22_031700	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
L3i22_031790	COG1509	lysine 2,3-aminomutase activity
L3i22_031800	COG0604	alcohol dehydrogenase
L3i22_031810	COG1228	amidohydrolase
L3i22_031820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L3i22_031830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L3i22_031840	COG1607	acyl-coa hydrolase
L3i22_031870	COG0463	Glycosyl transferase, family 2
L3i22_032010	COG0640	Transcriptional regulator
L3i22_032080	COG0583	DNA-binding transcription factor activity
L3i22_032090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_032110	COG0601	transmembrane transport
L3i22_032120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_032130	COG0444	Belongs to the ABC transporter superfamily
L3i22_032140	COG4608	Belongs to the ABC transporter superfamily
L3i22_032150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_032160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_032200	COG4214	carbohydrate transport
L3i22_032210	COG4213	ABC transporter substrate-binding protein
L3i22_032230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L3i22_032240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L3i22_032250	COG2080	2 iron, 2 sulfur cluster binding
L3i22_032420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_032440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L3i22_032470	COG0789	Transcriptional regulator
L3i22_032520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L3i22_032530	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L3i22_032550	COG0683	leucine binding
L3i22_032560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3i22_032580	COG0586	Pfam SNARE associated Golgi protein
L3i22_032600	COG0477	Major facilitator Superfamily
L3i22_032630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_032680	COG1501	Belongs to the glycosyl hydrolase 31 family
L3i22_032770	COG1053	succinate dehydrogenase
L3i22_032780	COG1309	transcriptional regulator
L3i22_032790	COG3459	Glycosyltransferase 36 associated
L3i22_033020	COG0488	(ABC) transporter
L3i22_033040	COG3485	protocatechuate 3,4-dioxygenase
L3i22_033080	COG0583	DNA-binding transcription factor activity
L3i22_033090	COG0183	Belongs to the thiolase family
L3i22_033110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L3i22_033180	COG0559	Belongs to the binding-protein-dependent transport system permease family
L3i22_033220	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_033300	COG3507	Belongs to the glycosyl hydrolase 43 family
L3i22_033390	COG3250	beta-galactosidase activity
L3i22_033400	COG4585	Histidine kinase
L3i22_033410	COG3300	MHYT domain
L3i22_033410	COG5001	Diguanylate cyclase
L3i22_033430	COG0596	Alpha beta hydrolase
L3i22_033440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L3i22_033450	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
L3i22_033500	COG0701	Predicted permease
L3i22_033530	COG1846	Transcriptional regulator
L3i22_033540	COG1902	pentaerythritol trinitrate reductase activity
L3i22_033550	COG0326	Molecular chaperone. Has ATPase activity
L3i22_033580	COG1690	Belongs to the RtcB family
L3i22_033600	COG0784	Response regulator, receiver
L3i22_033700	COG0583	DNA-binding transcription factor activity
L3i22_033710	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_033740	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L3i22_033780	COG0750	zinc metalloprotease
L3i22_033810	COG0577	efflux transmembrane transporter activity
L3i22_033820	COG0577	efflux transmembrane transporter activity
L3i22_033820	COG1136	(ABC) transporter
L3i22_033830	COG4585	Histidine kinase
L3i22_033840	COG2197	response regulator
L3i22_033880	COG2197	response regulator
L3i22_033890	COG0436	Aminotransferase
L3i22_033910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L3i22_033940	COG1309	transcriptional regulator
L3i22_033960	COG4412	M6 family metalloprotease domain protein
L3i22_033960	COG1404	Belongs to the peptidase S8 family
L3i22_033970	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L3i22_033970	COG1672	PFAM Archaeal ATPase
L3i22_033980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L3i22_033980	COG1017	nitric oxide dioxygenase activity
L3i22_034000	COG2814	Major facilitator Superfamily
L3i22_034020	COG2205	protein histidine kinase activity
L3i22_034030	COG0745	RESPONSE REGULATOR receiver
L3i22_034040	COG0475	glutathione-regulated potassium exporter activity
L3i22_034080	COG2318	DinB family
L3i22_034090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_034110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L3i22_034130	COG2986	histidine ammonia-lyase
L3i22_034150	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_034200	COG1522	sequence-specific DNA binding
L3i22_034220	COG0242	peptide deformylase activity
L3i22_034420	COG0783	Belongs to the Dps family
L3i22_034460	COG3903	Transcriptional regulator
L3i22_034460	COG3629	intracellular signal transduction
L3i22_034480	COG0028	Belongs to the TPP enzyme family
L3i22_034530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L3i22_034540	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_034550	COG2197	response regulator
L3i22_034560	COG2020	methyltransferase activity
L3i22_034630	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_034690	COG2197	response regulator
L3i22_034710	COG2357	RelA SpoT domain protein
L3i22_034760	COG1309	transcriptional regulator
L3i22_034780	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_034900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_034930	COG0019	diaminopimelate decarboxylase activity
L3i22_034960	COG3940	Belongs to the glycosyl hydrolase 43 family
L3i22_034990	COG1819	glycosyl
L3i22_035000	COG3046	protein related to deoxyribodipyrimidine photolyase
L3i22_035020	COG2815	serine threonine protein kinase
L3i22_035020	COG0515	serine threonine protein kinase
L3i22_035040	COG2072	flavoprotein involved in K transport
L3i22_035060	COG2770	Histidine kinase
L3i22_035060	COG2208	phosphoserine phosphatase activity
L3i22_035140	COG4251	negative regulation of phosphorylation
L3i22_035150	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L3i22_035160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3i22_035210	COG0366	Alpha amylase catalytic
L3i22_035220	COG0395	ABC-type sugar transport system, permease component
L3i22_035230	COG1175	transmembrane transport
L3i22_035240	COG1653	transport
L3i22_035270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_035350	COG0402	S-adenosylhomocysteine deaminase activity
L3i22_035360	COG1414	Transcriptional regulator
L3i22_035420	COG1064	alcohol dehydrogenase
L3i22_035430	COG1120	ATPase activity
L3i22_035440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_035450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_035460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L3i22_035480	COG1535	isochorismatase
L3i22_035480	COG3433	isochorismatase activity
L3i22_035530	COG1132	(ABC) transporter
L3i22_035540	COG1132	(ABC) transporter
L3i22_035570	COG0475	glutathione-regulated potassium exporter activity
L3i22_035580	COG1169	isochorismate synthase
L3i22_035590	COG1021	2,3-dihydroxybenzoate-AMP ligase
L3i22_035600	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L3i22_035610	COG0823	Involved in the tonB-independent uptake of proteins
L3i22_035620	COG2261	transglycosylase associated protein
L3i22_035650	COG1024	Enoyl-CoA hydratase
L3i22_035780	COG0483	inositol monophosphate 1-phosphatase activity
L3i22_035870	COG2197	response regulator
L3i22_035920	COG1609	Transcriptional regulator
L3i22_035930	COG1653	transport
L3i22_035940	COG1175	transmembrane transport
L3i22_035950	COG0395	ABC-type sugar transport system, permease component
L3i22_036040	COG2072	flavoprotein involved in K transport
L3i22_036080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_036110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L3i22_036160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L3i22_036170	COG1737	Transcriptional regulator
L3i22_036190	COG3876	Protein conserved in bacteria
L3i22_036200	COG1472	Belongs to the glycosyl hydrolase 3 family
L3i22_036210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L3i22_036220	COG1653	transport
L3i22_036230	COG1175	transmembrane transport
L3i22_036240	COG0395	ABC-type sugar transport system, permease component
L3i22_036270	COG4585	Histidine kinase
L3i22_036300	COG1063	alcohol dehydrogenase
L3i22_036350	COG2807	transmembrane transport
L3i22_036360	COG2186	Transcriptional regulator
L3i22_036370	COG2205	protein histidine kinase activity
L3i22_036380	COG0745	RESPONSE REGULATOR receiver
L3i22_036430	COG2197	response regulator
L3i22_036440	COG1136	(ABC) transporter
L3i22_036440	COG0577	efflux transmembrane transporter activity
L3i22_036470	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_036510	COG0803	Belongs to the bacterial solute-binding protein 9 family
L3i22_036520	COG1121	(ABC) transporter
L3i22_036530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L3i22_036670	COG4941	Belongs to the sigma-70 factor family
L3i22_036680	COG3795	YCII-related domain
L3i22_036700	COG2860	membrane
L3i22_036730	COG5001	Diguanylate cyclase
L3i22_036790	COG1073	alpha beta
L3i22_036900	COG0641	radical SAM
L3i22_037020	COG2814	Major facilitator Superfamily
L3i22_037160	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L3i22_037200	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
L3i22_037260	COG0702	epimerase
L3i22_037270	COG1064	alcohol dehydrogenase
L3i22_037320	COG3903	Transcriptional regulator
L3i22_037320	COG3629	intracellular signal transduction
L3i22_037330	COG2514	catechol 2,3-dioxygenase activity
L3i22_037440	COG0154	amidase activity
L3i22_037460	COG0670	Belongs to the BI1 family
L3i22_037470	COG2267	carboxylic ester hydrolase activity
L3i22_037480	COG3387	PFAM Glycoside hydrolase 15-related
L3i22_037520	COG4941	Belongs to the sigma-70 factor family
L3i22_037540	COG0745	RESPONSE REGULATOR receiver
L3i22_037550	COG2205	protein histidine kinase activity
L3i22_037560	COG1376	ErfK ybiS ycfS ynhG family protein
L3i22_037590	COG1079	Belongs to the binding-protein-dependent transport system permease family
L3i22_037600	COG4603	Belongs to the binding-protein-dependent transport system permease family
L3i22_037610	COG3845	ABC transporter
L3i22_037630	COG1802	Transcriptional regulator
L3i22_037680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L3i22_037690	COG3629	intracellular signal transduction
L3i22_037690	COG3903	Transcriptional regulator
L3i22_037700	COG3469	chitinase activity
L3i22_037710	COG1131	(ABC) transporter
L3i22_037780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_037820	COG2319	Wd-40 repeat
L3i22_037840	COG3629	intracellular signal transduction
L3i22_037880	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_038050	COG2197	response regulator
L3i22_038070	COG2409	Drug exporters of the RND superfamily
L3i22_038230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_038250	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_038280	COG0640	Transcriptional regulator
L3i22_038290	COG0604	alcohol dehydrogenase
L3i22_038350	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_038370	COG1309	transcriptional regulator
L3i22_038470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L3i22_038480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L3i22_038510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L3i22_038530	COG0438	transferase activity, transferring glycosyl groups
L3i22_038630	COG2197	response regulator
L3i22_038720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L3i22_038760	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
L3i22_038760	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
L3i22_038970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L3i22_039010	COG0583	DNA-binding transcription factor activity
L3i22_039080	COG0840	transmembrane signaling receptor activity
L3i22_039090	COG3321	synthase
L3i22_039090	COG0604	alcohol dehydrogenase
L3i22_039090	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_039160	COG0596	Alpha beta hydrolase
L3i22_039290	COG1309	transcriptional regulator
L3i22_039310	COG0667	Aldo Keto reductase
L3i22_039320	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_039370	COG2197	response regulator
L3i22_039380	COG2197	response regulator
L3i22_039390	COG1546	Belongs to the CinA family
L3i22_039390	COG1058	Belongs to the CinA family
L3i22_039700	COG0667	Aldo Keto reductase
L3i22_039720	COG0667	Aldo Keto reductase
L3i22_039790	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L3i22_039820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L3i22_040070	COG2318	DinB family
L3i22_040130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L3i22_040140	COG2226	methyltransferase
L3i22_040240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L3i22_040370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L3i22_040410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3i22_040440	COG1595	DNA-templated transcription, initiation
L3i22_040470	COG0697	spore germination
L3i22_040540	COG1196	nuclear chromosome segregation
L3i22_040540	COG0739	heme binding
L3i22_040540	COG0741	lytic transglycosylase activity
L3i22_040670	COG1940	carbohydrate kinase activity
L3i22_040730	COG1175	transmembrane transport
L3i22_040740	COG0395	ABC-type sugar transport system, permease component
L3i22_040750	COG1472	Belongs to the glycosyl hydrolase 3 family
L3i22_040770	COG1960	acyl-CoA dehydrogenase activity
L3i22_040800	COG4104	PAAR repeat-containing protein
L3i22_040840	COG5002	protein histidine kinase activity
L3i22_040840	COG2205	protein histidine kinase activity
L3i22_040840	COG0784	Response regulator, receiver
L3i22_040870	COG2326	polyphosphate kinase activity
L3i22_040960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L3i22_040970	COG1846	Transcriptional regulator
L3i22_040970	COG1940	carbohydrate kinase activity
L3i22_040990	COG1175	transmembrane transport
L3i22_041000	COG0395	ABC-type sugar transport system, permease component
L3i22_041090	COG0339	signal peptide processing
L3i22_041110	COG3629	intracellular signal transduction
L3i22_041110	COG3903	Transcriptional regulator
L3i22_041280	COG0604	alcohol dehydrogenase
L3i22_041390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L3i22_041420	COG3866	Pectate lyase
L3i22_041480	COG0604	alcohol dehydrogenase
L3i22_041480	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_041480	COG3321	synthase
L3i22_041500	COG2226	methyltransferase
L3i22_041550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L3i22_041560	COG2192	nodulation
L3i22_041600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L3i22_041640	COG0525	valine-tRNA ligase activity
L3i22_041660	COG2814	Major facilitator Superfamily
L3i22_041680	COG2226	methyltransferase
L3i22_041830	COG1136	(ABC) transporter
L3i22_041890	COG3903	Transcriptional regulator
L3i22_041890	COG3629	intracellular signal transduction
L3i22_041900	COG2814	Major facilitator Superfamily
L3i22_041910	COG1560	Kdo2-lipid A biosynthetic process
L3i22_041960	COG2197	response regulator
L3i22_042080	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_042120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_042180	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_042220	COG0494	nUDIX hydrolase
L3i22_042260	COG0667	Aldo Keto reductase
L3i22_042350	COG2814	Major facilitator Superfamily
L3i22_042380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L3i22_042400	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_042450	COG1073	alpha beta
L3i22_042490	COG3250	beta-galactosidase activity
L3i22_042590	COG2226	methyltransferase
L3i22_042630	COG0446	pyridine nucleotide-disulphide oxidoreductase
L3i22_042660	COG1175	transmembrane transport
L3i22_042670	COG0395	ABC-type sugar transport system, permease component
L3i22_042730	COG4214	carbohydrate transport
L3i22_042760	COG1129	ABC transporter
L3i22_042770	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_042780	COG4948	Mandelate Racemase Muconate Lactonizing
L3i22_042790	COG2186	Transcriptional regulator
L3i22_042860	COG0300	oxidoreductase activity
L3i22_042870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3i22_042930	COG3540	Alkaline phosphatase
L3i22_043020	COG0492	ferredoxin-NADP+ reductase activity
L3i22_043050	COG0596	Alpha beta hydrolase
L3i22_043070	COG1595	DNA-templated transcription, initiation
L3i22_043090	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_043100	COG1309	transcriptional regulator
L3i22_043110	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_043160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L3i22_043190	COG0758	DNA mediated transformation
L3i22_043280	COG3706	GGDEF domain
L3i22_043290	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_043340	COG0561	phosphatase activity
L3i22_043360	COG4221	oxidoreductase activity
L3i22_043440	COG5002	protein histidine kinase activity
L3i22_043460	COG1063	alcohol dehydrogenase
L3i22_043480	COG0784	Response regulator, receiver
L3i22_043510	COG0515	serine threonine protein kinase
L3i22_043510	COG2815	serine threonine protein kinase
L3i22_043580	COG0789	Transcriptional regulator
L3i22_043610	COG0076	glutamate decarboxylase activity
L3i22_043620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3i22_043630	COG0300	oxidoreductase activity
L3i22_043640	COG1278	Cold shock
L3i22_043670	COG2205	protein histidine kinase activity
L3i22_043680	COG0745	RESPONSE REGULATOR receiver
L3i22_043720	COG0395	ABC-type sugar transport system, permease component
L3i22_043770	COG3706	GGDEF domain
L3i22_043820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_043820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L3i22_043840	COG0589	response to stress
L3i22_043890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L3i22_043900	COG3559	Exporter of polyketide antibiotics
L3i22_043910	COG1131	(ABC) transporter
L3i22_044040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L3i22_044060	COG3835	regulator
L3i22_044070	COG3903	Transcriptional regulator
L3i22_044070	COG3629	intracellular signal transduction
L3i22_044090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L3i22_044150	COG1140	nitrate reductase beta subunit
L3i22_044160	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L3i22_044200	COG1278	Cold shock
L3i22_044300	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_044310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L3i22_044360	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_044380	COG1129	ABC transporter
L3i22_044400	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_044530	COG0367	asparagine synthase
L3i22_044580	COG0840	transmembrane signaling receptor activity
L3i22_044590	COG5002	protein histidine kinase activity
L3i22_044610	COG5002	protein histidine kinase activity
L3i22_044640	COG2267	carboxylic ester hydrolase activity
L3i22_044650	COG3629	intracellular signal transduction
L3i22_044650	COG3903	Transcriptional regulator
L3i22_044730	COG0330	HflC and HflK could
L3i22_044790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L3i22_044860	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_045050	COG2267	carboxylic ester hydrolase activity
L3i22_045070	COG2217	Heavy metal translocating P-type atpase
L3i22_045080	COG1937	Protein conserved in bacteria
L3i22_045100	COG0745	RESPONSE REGULATOR receiver
L3i22_045110	COG5002	protein histidine kinase activity
L3i22_045150	COG2920	part of a sulfur-relay system
L3i22_045170	COG0589	response to stress
L3i22_045200	COG3842	ATPase activity
L3i22_045230	COG1131	(ABC) transporter
L3i22_045300	COG1013	pyruvate-flavodoxin oxidoreductase activity
L3i22_045300	COG0674	pyruvate-flavodoxin oxidoreductase activity
L3i22_045300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L3i22_045300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L3i22_045310	COG0493	'glutamate synthase
L3i22_045320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L3i22_045350	COG0588	phosphoglycerate mutase activity
L3i22_045390	COG1830	Aldolase
L3i22_045430	COG0671	phosphoesterase, PA-phosphatase related
L3i22_045520	COG3409	Peptidoglycan-binding domain 1 protein
L3i22_045520	COG3757	hydrolase, family 25
L3i22_045570	COG2814	Major facilitator Superfamily
L3i22_045630	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L3i22_045670	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L3i22_045720	COG2814	Major facilitator Superfamily
L3i22_045750	COG1017	nitric oxide dioxygenase activity
L3i22_045750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L3i22_045780	COG0745	RESPONSE REGULATOR receiver
L3i22_045790	COG2205	protein histidine kinase activity
L3i22_045810	COG1131	(ABC) transporter
L3i22_045830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L3i22_045850	COG2203	Gaf domain
L3i22_045850	COG3706	GGDEF domain
L3i22_045850	COG4251	negative regulation of phosphorylation
L3i22_045850	COG5001	Diguanylate cyclase
L3i22_045890	COG0840	transmembrane signaling receptor activity
L3i22_046110	COG3629	intracellular signal transduction
L3i22_046110	COG3903	Transcriptional regulator
L3i22_046140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L3i22_046160	COG0596	Alpha beta hydrolase
L3i22_046170	COG0110	maltose O-acetyltransferase activity
L3i22_046250	COG2197	response regulator
L3i22_046260	COG4585	Histidine kinase
L3i22_046270	COG2409	Drug exporters of the RND superfamily
L3i22_046280	COG0583	DNA-binding transcription factor activity
L3i22_046290	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_046360	COG0596	Alpha beta hydrolase
L3i22_046460	COG0657	acetylesterase activity
L3i22_046720	COG1396	sequence-specific DNA binding
L3i22_046760	COG0300	oxidoreductase activity
L3i22_046800	COG4251	negative regulation of phosphorylation
L3i22_046820	COG1737	Transcriptional regulator
L3i22_046830	COG2182	Extracellular solute-binding protein
L3i22_046840	COG1175	transmembrane transport
L3i22_046850	COG0395	ABC-type sugar transport system, permease component
L3i22_046860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L3i22_046930	COG1846	Transcriptional regulator
L3i22_046930	COG1940	carbohydrate kinase activity
L3i22_046940	COG4213	ABC transporter substrate-binding protein
L3i22_046960	COG4214	carbohydrate transport
L3i22_047010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L3i22_047020	COG1216	Glycosyl transferase, family 2
L3i22_047070	COG1309	transcriptional regulator
L3i22_047090	COG1733	regulation of RNA biosynthetic process
L3i22_047170	COG0667	Aldo Keto reductase
L3i22_047210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L3i22_047250	COG0395	ABC-type sugar transport system, permease component
L3i22_047260	COG1609	Transcriptional regulator
L3i22_047300	COG0640	Transcriptional regulator
L3i22_047310	COG4585	Histidine kinase
L3i22_047320	COG2197	response regulator
L3i22_047330	COG3903	Transcriptional regulator
L3i22_047330	COG3629	intracellular signal transduction
L3i22_047400	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_047420	COG4585	Histidine kinase
L3i22_047430	COG2197	response regulator
L3i22_047560	COG2226	methyltransferase
L3i22_047610	COG2226	methyltransferase
L3i22_047670	COG1695	Transcriptional regulator
L3i22_047710	COG1401	restriction endodeoxyribonuclease activity
L3i22_047730	COG1846	Transcriptional regulator
L3i22_047740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L3i22_047800	COG2815	serine threonine protein kinase
L3i22_047800	COG0515	serine threonine protein kinase
L3i22_047830	COG4941	Belongs to the sigma-70 factor family
L3i22_047870	COG0400	carboxylic ester hydrolase activity
L3i22_047890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_047950	COG2267	carboxylic ester hydrolase activity
L3i22_048040	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_048090	COG0183	Belongs to the thiolase family
L3i22_048190	COG2264	protein methyltransferase activity
L3i22_048250	COG1309	transcriptional regulator
L3i22_048280	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_048350	COG0535	radical SAM domain protein
L3i22_048370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L3i22_048390	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_048410	COG0300	oxidoreductase activity
L3i22_048500	COG2197	response regulator
L3i22_048520	COG0443	Heat shock 70 kDa protein
L3i22_048540	COG0673	inositol 2-dehydrogenase activity
L3i22_048560	COG0583	DNA-binding transcription factor activity
L3i22_048600	COG1175	transmembrane transport
L3i22_048610	COG0395	ABC-type sugar transport system, permease component
L3i22_048620	COG3250	beta-galactosidase activity
L3i22_048720	COG4124	Belongs to the glycosyl hydrolase 26 family
L3i22_048740	COG1940	carbohydrate kinase activity
L3i22_048770	COG0483	inositol monophosphate 1-phosphatase activity
L3i22_048820	COG3386	PFAM SMP-30 Gluconolaconase
L3i22_048830	COG0129	dihydroxy-acid dehydratase activity
L3i22_048860	COG1703	isobutyryl-CoA mutase activity
L3i22_048860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L3i22_048860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L3i22_048940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3i22_048940	COG0300	oxidoreductase activity
L3i22_048940	COG4221	oxidoreductase activity
L3i22_048940	COG3321	synthase
L3i22_048950	COG0300	oxidoreductase activity
L3i22_048950	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_048950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L3i22_048950	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_048950	COG3321	synthase
L3i22_049080	COG2211	Major facilitator Superfamily
L3i22_049100	COG0367	asparagine synthase
L3i22_049120	COG0438	transferase activity, transferring glycosyl groups
L3i22_049170	COG0386	Belongs to the glutathione peroxidase family
L3i22_049240	COG1051	belongs to the nudix hydrolase family
L3i22_049250	COG2226	methyltransferase
L3i22_049280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_049300	COG3290	protein histidine kinase activity
L3i22_049310	COG4565	transcriptional regulatory protein
L3i22_049340	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L3i22_049370	COG3629	intracellular signal transduction
L3i22_049370	COG3903	Transcriptional regulator
L3i22_049380	COG0563	adenylate kinase activity
L3i22_049430	COG2186	Transcriptional regulator
L3i22_049470	COG4608	Belongs to the ABC transporter superfamily
L3i22_049490	COG1940	carbohydrate kinase activity
L3i22_049580	COG0395	ABC-type sugar transport system, permease component
L3i22_049590	COG1175	transmembrane transport
L3i22_049680	COG3345	alpha-galactosidase
L3i22_049690	COG3507	Belongs to the glycosyl hydrolase 43 family
L3i22_049720	COG3693	PFAM glycoside hydrolase, family 10
L3i22_049740	COG3693	PFAM glycoside hydrolase, family 10
L3i22_049800	COG4209	transmembrane transport
L3i22_049810	COG0395	ABC-type sugar transport system, permease component
L3i22_049820	COG1653	transport
L3i22_049940	COG3458	cephalosporin-C deacetylase activity
L3i22_049950	COG3345	alpha-galactosidase
L3i22_049960	COG1940	carbohydrate kinase activity
L3i22_049960	COG1846	Transcriptional regulator
L3i22_049980	COG0463	Glycosyl transferase, family 2
L3i22_049990	COG3979	chitinase
L3i22_050000	COG2267	carboxylic ester hydrolase activity
L3i22_050020	COG2273	Hydrolase Family 16
L3i22_050030	COG4124	Belongs to the glycosyl hydrolase 26 family
L3i22_050030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L3i22_050170	COG3226	Transcriptional regulator
L3i22_050210	COG2986	histidine ammonia-lyase
L3i22_050260	COG1595	DNA-templated transcription, initiation
L3i22_050310	COG4608	Belongs to the ABC transporter superfamily
L3i22_050320	COG0444	Belongs to the ABC transporter superfamily
L3i22_050330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_050340	COG0601	transmembrane transport
L3i22_050350	COG0747	negative chemotaxis
L3i22_050370	COG0604	alcohol dehydrogenase
L3i22_050390	COG1846	Transcriptional regulator
L3i22_050400	COG2986	histidine ammonia-lyase
L3i22_050420	COG1174	glycine betaine transport
L3i22_050430	COG1174	glycine betaine transport
L3i22_050460	COG0789	Transcriptional regulator
L3i22_050490	COG0477	Major facilitator Superfamily
L3i22_050530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L3i22_050560	COG2197	response regulator
L3i22_050570	COG4585	Histidine kinase
L3i22_050690	COG3903	Transcriptional regulator
L3i22_050690	COG2197	response regulator
L3i22_050700	COG2197	response regulator
L3i22_050770	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_050770	COG1454	alcohol dehydrogenase
L3i22_050780	COG0589	response to stress
L3i22_050790	COG0589	response to stress
L3i22_050820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L3i22_050820	COG0574	Belongs to the PEP-utilizing enzyme family
L3i22_050900	COG1309	transcriptional regulator
L3i22_050980	COG0596	Alpha beta hydrolase
L3i22_050990	COG1733	regulation of RNA biosynthetic process
L3i22_051050	COG4977	sequence-specific DNA binding
L3i22_051150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L3i22_051180	COG2267	carboxylic ester hydrolase activity
L3i22_051210	COG1175	transmembrane transport
L3i22_051230	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
L3i22_051290	COG1120	ATPase activity
L3i22_051320	COG3401	FG-GAP repeat protein
L3i22_051330	COG3401	FG-GAP repeat protein
L3i22_051360	COG1073	alpha beta
L3i22_051460	COG0516	GMP reductase activity
L3i22_051460	COG0517	IMP dehydrogenase activity
L3i22_051510	COG3158	transport of potassium into the cell
L3i22_051530	COG3447	MASE1 domain protein
L3i22_051530	COG5001	Diguanylate cyclase
L3i22_051530	COG5002	protein histidine kinase activity
L3i22_051660	COG1063	alcohol dehydrogenase
L3i22_051720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L3i22_051720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L3i22_051730	COG2205	protein histidine kinase activity
L3i22_051730	COG0784	Response regulator, receiver
L3i22_051730	COG2198	Histidine kinase
L3i22_051750	COG1404	Belongs to the peptidase S8 family
L3i22_051790	COG0667	Aldo Keto reductase
L3i22_051800	COG0222	ribosome binding
L3i22_051920	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L3i22_051930	COG3266	domain, Protein
L3i22_051930	COG0515	serine threonine protein kinase
L3i22_051990	COG1742	UPF0060 membrane protein
L3i22_052020	COG1595	DNA-templated transcription, initiation
L3i22_052100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L3i22_052140	COG4677	pectinesterase activity
L3i22_052150	COG4585	Histidine kinase
L3i22_052160	COG2197	response regulator
L3i22_052360	COG0477	Major facilitator Superfamily
L3i22_052420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L3i22_052430	COG0438	transferase activity, transferring glycosyl groups
L3i22_052480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L3i22_052500	COG4585	Histidine kinase
L3i22_052510	COG2197	response regulator
L3i22_052620	COG0475	glutathione-regulated potassium exporter activity
L3i22_052640	COG2267	carboxylic ester hydrolase activity
L3i22_052650	COG0667	Aldo Keto reductase
L3i22_052680	COG0277	FAD linked oxidase domain protein
L3i22_052750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L3i22_052780	COG0835	chemotaxis
L3i22_052790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L3i22_052800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
L3i22_052810	COG2201	protein-glutamate methylesterase activity
L3i22_052820	COG0840	transmembrane signaling receptor activity
L3i22_052850	COG2198	Histidine kinase
L3i22_052850	COG0643	Histidine kinase
L3i22_052910	COG1733	regulation of RNA biosynthetic process
L3i22_052980	COG0405	Gamma-glutamyltransferase
L3i22_053050	COG1984	allophanate hydrolase subunit 2
L3i22_053060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L3i22_053140	COG1309	transcriptional regulator
L3i22_053250	COG0583	DNA-binding transcription factor activity
L3i22_053280	COG5001	Diguanylate cyclase
L3i22_053280	COG4251	negative regulation of phosphorylation
L3i22_053280	COG2203	Gaf domain
L3i22_053280	COG3706	GGDEF domain
L3i22_053310	COG1136	(ABC) transporter
L3i22_053310	COG0577	efflux transmembrane transporter activity
L3i22_053400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L3i22_053410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L3i22_053430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_053500	COG0463	Glycosyl transferase, family 2
L3i22_053540	COG0640	Transcriptional regulator
L3i22_053560	COG4948	Mandelate Racemase Muconate Lactonizing
L3i22_053570	COG0179	Fumarylacetoacetate (FAA) hydrolase
L3i22_053650	COG4682	membrane
L3i22_053680	COG0640	Transcriptional regulator
L3i22_053750	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_053830	COG0477	Major facilitator Superfamily
L3i22_053850	COG4941	Belongs to the sigma-70 factor family
L3i22_053880	COG4941	Belongs to the sigma-70 factor family
L3i22_053900	COG2814	Major facilitator Superfamily
L3i22_053910	COG4941	Belongs to the sigma-70 factor family
L3i22_053920	COG3795	YCII-related domain
L3i22_053930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L3i22_054020	COG0577	efflux transmembrane transporter activity
L3i22_054020	COG1136	(ABC) transporter
L3i22_054040	COG2197	response regulator
L3i22_054080	COG0596	Alpha beta hydrolase
L3i22_054090	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_054140	COG4106	trans-aconitate 2-methyltransferase activity
L3i22_054210	COG4974	Belongs to the 'phage' integrase family
L3i22_054230	COG0667	Aldo Keto reductase
L3i22_054300	COG0183	Belongs to the thiolase family
L3i22_054390	COG0583	DNA-binding transcription factor activity
L3i22_054400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L3i22_054410	COG3903	Transcriptional regulator
L3i22_054410	COG3629	intracellular signal transduction
L3i22_054440	COG2132	Multicopper oxidase
L3i22_054520	COG1131	(ABC) transporter
L3i22_054530	COG0842	Transport permease protein
L3i22_054540	COG4585	Histidine kinase
L3i22_054550	COG2197	response regulator
L3i22_054570	COG1191	sigma factor activity
L3i22_054590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_054600	COG0488	(ABC) transporter
L3i22_054610	COG1968	undecaprenyl-diphosphatase activity
L3i22_054630	COG2226	methyltransferase
L3i22_054700	COG2226	methyltransferase
L3i22_054720	COG3173	Aminoglycoside phosphotransferase
L3i22_054840	COG1522	sequence-specific DNA binding
L3i22_054930	COG2270	Major facilitator Superfamily
L3i22_055050	COG0456	acetyltransferase
L3i22_055050	COG1846	Transcriptional regulator
L3i22_055090	COG1764	response to oxidative stress
L3i22_055100	COG1846	Transcriptional regulator
L3i22_055140	COG4702	Belongs to the UPF0303 family
L3i22_055200	COG0019	diaminopimelate decarboxylase activity
L3i22_055260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L3i22_055290	COG0596	Alpha beta hydrolase
L3i22_055480	COG0667	Aldo Keto reductase
L3i22_055520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L3i22_055550	COG0667	Aldo Keto reductase
L3i22_055590	COG0714	Associated with various cellular activities
L3i22_055720	COG1234	tRNA 3'-trailer cleavage
L3i22_055740	COG0242	peptide deformylase activity
L3i22_055760	COG1595	DNA-templated transcription, initiation
L3i22_055770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L3i22_055790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L3i22_055790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L3i22_055800	COG0667	Aldo Keto reductase
L3i22_055950	COG2211	Major facilitator Superfamily
L3i22_055970	COG0672	)-iron permease
L3i22_055990	COG2837	iron assimilation
L3i22_056070	COG1309	transcriptional regulator
L3i22_056190	COG3250	beta-galactosidase activity
L3i22_056200	COG0395	ABC-type sugar transport system, permease component
L3i22_056210	COG1175	transmembrane transport
L3i22_056230	COG1609	Transcriptional regulator
L3i22_056270	COG3281	Trehalose synthase
L3i22_056290	COG1819	glycosyl
L3i22_056310	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_056340	COG1733	regulation of RNA biosynthetic process
L3i22_056350	COG2910	NAD(P)H-binding
L3i22_056480	COG4585	Histidine kinase
L3i22_056510	COG0583	DNA-binding transcription factor activity
L3i22_056540	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_056620	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_056630	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_056660	COG0110	maltose O-acetyltransferase activity
L3i22_056670	COG0604	alcohol dehydrogenase
L3i22_056670	COG3321	synthase
L3i22_056820	COG0456	acetyltransferase
L3i22_056860	COG0477	Major facilitator Superfamily
L3i22_056970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L3i22_056980	COG4585	Histidine kinase
L3i22_056990	COG2197	response regulator
L3i22_057060	COG2268	Band 7 protein
L3i22_057090	COG2815	serine threonine protein kinase
L3i22_057090	COG0515	serine threonine protein kinase
L3i22_057120	COG2304	oxidoreductase activity
L3i22_057130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L3i22_057180	COG0477	Major facilitator Superfamily
L3i22_057200	COG1247	-acetyltransferase
L3i22_057210	COG0667	Aldo Keto reductase
L3i22_057220	COG1733	regulation of RNA biosynthetic process
L3i22_057250	COG0596	Alpha beta hydrolase
L3i22_057250	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3i22_057300	COG1522	sequence-specific DNA binding
L3i22_057320	COG4585	Histidine kinase
L3i22_057330	COG2197	response regulator
L3i22_057420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3i22_057430	COG0346	lactoylglutathione lyase activity
L3i22_057500	COG1024	Enoyl-CoA hydratase
L3i22_057520	COG1695	Transcriptional regulator
L3i22_057540	COG0446	pyridine nucleotide-disulphide oxidoreductase
L3i22_057540	COG1902	pentaerythritol trinitrate reductase activity
L3i22_057550	COG1309	transcriptional regulator
L3i22_057560	COG0667	Aldo Keto reductase
L3i22_057610	COG1760	l-serine dehydratase
L3i22_057620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L3i22_057660	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_057680	COG2205	protein histidine kinase activity
L3i22_057690	COG0745	RESPONSE REGULATOR receiver
L3i22_057710	COG0577	efflux transmembrane transporter activity
L3i22_057710	COG1136	(ABC) transporter
L3i22_057730	COG3706	GGDEF domain
L3i22_057760	COG1309	transcriptional regulator
L3i22_057780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_057790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3i22_057800	COG0024	Methionine aminopeptidase
L3i22_057890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L3i22_057950	COG2197	response regulator
L3i22_058010	COG2197	response regulator
L3i22_058030	COG2197	response regulator
L3i22_058040	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_058060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L3i22_058090	COG4585	Histidine kinase
L3i22_058100	COG2409	Drug exporters of the RND superfamily
L3i22_058150	COG4585	Histidine kinase
L3i22_058160	COG2197	response regulator
L3i22_058260	COG2072	flavoprotein involved in K transport
L3i22_058280	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_058290	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L3i22_058300	COG0583	DNA-binding transcription factor activity
L3i22_058320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L3i22_058330	COG0531	amino acid
L3i22_058350	COG1309	transcriptional regulator
L3i22_058400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L3i22_058420	COG3537	Alpha-1,2-mannosidase
L3i22_058490	COG1175	transmembrane transport
L3i22_058510	COG1609	Transcriptional regulator
L3i22_058550	COG1278	Cold shock
L3i22_058580	COG1309	transcriptional regulator
L3i22_058620	COG1619	proteins homologs of microcin C7 resistance protein MccF
L3i22_058680	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L3i22_058680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L3i22_058690	COG2378	regulation of single-species biofilm formation
L3i22_058820	COG2050	protein possibly involved in aromatic compounds catabolism
L3i22_058930	COG1252	NADH dehydrogenase
L3i22_058940	COG2197	response regulator
L3i22_058950	COG4585	Histidine kinase
L3i22_058960	COG2132	Multicopper oxidase
L3i22_058990	COG1376	ErfK ybiS ycfS ynhG family protein
L3i22_059050	COG5002	protein histidine kinase activity
L3i22_059120	COG1309	transcriptional regulator
L3i22_059130	COG3173	Aminoglycoside phosphotransferase
L3i22_059160	COG3345	alpha-galactosidase
L3i22_059180	COG1175	transmembrane transport
L3i22_059190	COG0395	ABC-type sugar transport system, permease component
L3i22_059210	COG1672	PFAM Archaeal ATPase
L3i22_059210	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L3i22_059320	COG0583	DNA-binding transcription factor activity
L3i22_059340	COG2226	methyltransferase
L3i22_059420	COG2258	MOSC domain
L3i22_059450	COG5297	Belongs to the glycosyl hydrolase family 6
L3i22_059470	COG4770	biotin carboxylase activity
L3i22_059510	COG1309	transcriptional regulator
L3i22_059540	COG0010	Belongs to the arginase family
L3i22_059560	COG0667	Aldo Keto reductase
L3i22_059620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3i22_059620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3i22_059680	COG0515	serine threonine protein kinase
L3i22_059790	COG0745	RESPONSE REGULATOR receiver
L3i22_059800	COG2205	protein histidine kinase activity
L3i22_059840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L3i22_059960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L3i22_059960	COG0758	DNA mediated transformation
L3i22_060310	COG0745	RESPONSE REGULATOR receiver
L3i22_060500	COG4974	Belongs to the 'phage' integrase family
L3i22_060590	COG0210	DNA helicase
L3i22_061110	COG3547	Transposase (IS116 IS110 IS902 family)
L3i22_061180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L3i22_061220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L3i22_061260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L3i22_061280	COG1694	Mazg nucleotide pyrophosphohydrolase
L3i22_061310	COG1132	(ABC) transporter
L3i22_061350	COG0438	transferase activity, transferring glycosyl groups
L3i22_061370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L3i22_061420	COG0602	queuosine metabolic process
L3i22_061430	COG0720	synthase
L3i22_061440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L3i22_061460	COG0252	asparaginase activity
L3i22_061560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L3i22_061880	COG4974	Belongs to the 'phage' integrase family
L3i22_061950	COG3547	Transposase (IS116 IS110 IS902 family)
L3i22_061990	COG0494	nUDIX hydrolase
L3i22_062060	COG5001	Diguanylate cyclase
L3i22_062060	COG4251	negative regulation of phosphorylation
L3i22_062060	COG3706	GGDEF domain
L3i22_062060	COG2203	Gaf domain
L3i22_062090	COG4974	Belongs to the 'phage' integrase family
L3i22_062220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L3i22_062400	COG3537	Alpha-1,2-mannosidase
L3i22_062410	COG2207	Transcriptional regulator
L3i22_062410	COG4753	response regulator
L3i22_062430	COG1136	(ABC) transporter
L3i22_062430	COG0577	efflux transmembrane transporter activity
L3i22_062470	COG2201	protein-glutamate methylesterase activity
L3i22_062520	COG2070	2-Nitropropane dioxygenase
L3i22_062550	COG3300	MHYT domain
L3i22_062550	COG5001	Diguanylate cyclase
L3i22_062580	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L3i22_062620	COG1595	DNA-templated transcription, initiation
L3i22_062660	COG2376	Dihydroxyacetone kinase
L3i22_062700	COG2197	response regulator
L3i22_062710	COG1819	glycosyl
L3i22_062720	COG3973	AAA domain
L3i22_062750	COG1136	(ABC) transporter
L3i22_062760	COG1136	(ABC) transporter
L3i22_062760	COG0577	efflux transmembrane transporter activity
L3i22_062870	COG0531	amino acid
L3i22_062890	COG2172	sigma factor antagonist activity
L3i22_062890	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_062890	COG2208	phosphoserine phosphatase activity
L3i22_062910	COG2197	response regulator
L3i22_062920	COG2356	endonuclease I
L3i22_062930	COG2755	lipolytic protein G-D-S-L family
L3i22_062950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L3i22_063100	COG1606	tRNA processing
L3i22_063110	COG1691	(AIR) carboxylase
L3i22_063120	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
L3i22_063150	COG2072	flavoprotein involved in K transport
L3i22_063170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L3i22_063210	COG5001	Diguanylate cyclase
L3i22_063210	COG3300	MHYT domain
L3i22_063240	COG2837	iron assimilation
L3i22_063260	COG3336	cytochrome c oxidase
L3i22_063300	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_063330	COG0604	alcohol dehydrogenase
L3i22_063330	COG3321	synthase
L3i22_063350	COG1309	transcriptional regulator
L3i22_063360	COG0410	ABC transporter
L3i22_063390	COG0683	leucine binding
L3i22_063410	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_063430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L3i22_063440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L3i22_063450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L3i22_063530	COG2356	endonuclease I
L3i22_063540	COG1024	Enoyl-CoA hydratase
L3i22_063560	COG2936	dipeptidyl-peptidase activity
L3i22_063580	COG1609	Transcriptional regulator
L3i22_063600	COG2011	ABC-type metal ion transport system permease component
L3i22_063610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L3i22_063620	COG1464	Belongs to the NlpA lipoprotein family
L3i22_063640	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_063650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L3i22_063660	COG2072	flavoprotein involved in K transport
L3i22_063710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L3i22_063730	COG0431	NADPH-dependent FMN reductase
L3i22_063790	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_063820	COG1309	transcriptional regulator
L3i22_063840	COG4941	Belongs to the sigma-70 factor family
L3i22_063850	COG3795	YCII-related domain
L3i22_063860	COG0259	pyridoxamine-phosphate oxidase activity
L3i22_063870	COG2045	Belongs to the ComB family
L3i22_063890	COG0583	DNA-binding transcription factor activity
L3i22_063900	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_063930	COG0673	inositol 2-dehydrogenase activity
L3i22_063940	COG0483	inositol monophosphate 1-phosphatase activity
L3i22_063950	COG5002	protein histidine kinase activity
L3i22_064040	COG0657	acetylesterase activity
L3i22_064120	COG0702	epimerase
L3i22_064130	COG1733	regulation of RNA biosynthetic process
L3i22_064150	COG0477	Major facilitator Superfamily
L3i22_064180	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_064190	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_064200	COG1129	ABC transporter
L3i22_064210	COG1879	ABC-type sugar transport system periplasmic component
L3i22_064290	COG0477	Major facilitator Superfamily
L3i22_064330	COG0531	amino acid
L3i22_064440	COG1597	lipid kinase activity
L3i22_064530	COG0549	Belongs to the carbamate kinase family
L3i22_064540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L3i22_064550	COG2235	arginine
L3i22_064600	COG2197	response regulator
L3i22_064620	COG2197	response regulator
L3i22_064630	COG0366	Alpha amylase catalytic
L3i22_064690	COG0628	permease
L3i22_064780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L3i22_064840	COG0640	Transcriptional regulator
L3i22_064870	COG1309	transcriptional regulator
L3i22_064960	COG4948	Mandelate Racemase Muconate Lactonizing
L3i22_064970	COG0395	ABC-type sugar transport system, permease component
L3i22_064990	COG1653	transport
L3i22_065010	COG1088	dTDP-glucose 4,6-dehydratase activity
L3i22_065020	COG2084	Dehydrogenase
L3i22_065080	COG2197	response regulator
L3i22_065090	COG4585	Histidine kinase
L3i22_065190	COG0745	RESPONSE REGULATOR receiver
L3i22_065200	COG0438	transferase activity, transferring glycosyl groups
L3i22_065220	COG1597	lipid kinase activity
L3i22_065220	COG1803	Methylglyoxal synthase
L3i22_065250	COG1082	Xylose isomerase domain protein TIM barrel
L3i22_065280	COG2197	response regulator
L3i22_065340	COG0583	DNA-binding transcription factor activity
L3i22_065370	COG3663	DNA glycosylase
L3i22_065450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L3i22_065480	COG0583	DNA-binding transcription factor activity
L3i22_065490	COG0702	epimerase
L3i22_065510	COG2271	Major facilitator Superfamily
L3i22_065550	COG0596	Alpha beta hydrolase
L3i22_065560	COG2968	Membrane
L3i22_065570	COG2205	protein histidine kinase activity
L3i22_065580	COG0745	RESPONSE REGULATOR receiver
L3i22_065590	COG5001	Diguanylate cyclase
L3i22_065590	COG3300	MHYT domain
L3i22_065640	COG2272	Belongs to the type-B carboxylesterase lipase family
L3i22_065700	COG1136	(ABC) transporter
L3i22_065770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L3i22_065780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L3i22_065790	COG1609	Transcriptional regulator
L3i22_065840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3i22_065920	COG1846	Transcriptional regulator
L3i22_065930	COG0477	Major facilitator Superfamily
L3i22_065940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L3i22_065950	COG4585	Histidine kinase
L3i22_065960	COG2197	response regulator
L3i22_066000	COG3706	GGDEF domain
L3i22_066020	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_066030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_066050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L3i22_066090	COG1021	2,3-dihydroxybenzoate-AMP ligase
L3i22_066100	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L3i22_066100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L3i22_066110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L3i22_066120	COG1169	isochorismate synthase
L3i22_066160	COG0501	Belongs to the peptidase M48B family
L3i22_066200	COG0395	ABC-type sugar transport system, permease component
L3i22_066240	COG1609	Transcriptional regulator
L3i22_066260	COG1131	(ABC) transporter
L3i22_066320	COG2205	protein histidine kinase activity
L3i22_066350	COG1136	(ABC) transporter
L3i22_066350	COG0577	efflux transmembrane transporter activity
L3i22_066380	COG2197	response regulator
L3i22_066420	COG1136	(ABC) transporter
L3i22_066420	COG0577	efflux transmembrane transporter activity
L3i22_066430	COG1136	(ABC) transporter
L3i22_066430	COG0577	efflux transmembrane transporter activity
L3i22_066480	COG1131	(ABC) transporter
L3i22_066490	COG3851	Histidine kinase
L3i22_066500	COG2197	response regulator
L3i22_066530	COG1136	(ABC) transporter
L3i22_066560	COG4181	ATPase activity
L3i22_066570	COG4181	ATPase activity
L3i22_066600	COG0745	RESPONSE REGULATOR receiver
L3i22_066650	COG0586	Pfam SNARE associated Golgi protein
L3i22_066700	COG1968	undecaprenyl-diphosphatase activity
L3i22_066730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L3i22_066880	COG0745	RESPONSE REGULATOR receiver
L3i22_066920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L3i22_066940	COG2205	protein histidine kinase activity
L3i22_066950	COG0745	RESPONSE REGULATOR receiver
L3i22_066960	COG0586	Pfam SNARE associated Golgi protein
L3i22_066990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L3i22_067050	COG1136	(ABC) transporter
L3i22_067050	COG0577	efflux transmembrane transporter activity
L3i22_067130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L3i22_067140	COG0667	Aldo Keto reductase
L3i22_067210	COG2814	Major facilitator Superfamily
L3i22_067220	COG0028	Belongs to the TPP enzyme family
L3i22_067240	COG0596	Alpha beta hydrolase
L3i22_067270	COG0457	Tetratricopeptide repeat
L3i22_067300	COG4251	negative regulation of phosphorylation
L3i22_067390	COG0667	Aldo Keto reductase
L3i22_067400	COG0840	transmembrane signaling receptor activity
L3i22_067420	COG2267	carboxylic ester hydrolase activity
L3i22_067470	COG3321	synthase
L3i22_067470	COG0604	alcohol dehydrogenase
L3i22_067520	COG1846	Transcriptional regulator
L3i22_067550	COG4585	Histidine kinase
L3i22_067560	COG2197	response regulator
L3i22_067600	COG0789	Transcriptional regulator
L3i22_067730	COG0789	Transcriptional regulator
L3i22_067790	COG0640	Transcriptional regulator
L3i22_067810	COG1247	-acetyltransferase
L3i22_067820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L3i22_067830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L3i22_067840	COG0477	Major facilitator Superfamily
L3i22_067880	COG3507	Belongs to the glycosyl hydrolase 43 family
L3i22_067900	COG1309	transcriptional regulator
L3i22_067920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_067990	COG0515	serine threonine protein kinase
L3i22_068020	COG3903	Transcriptional regulator
L3i22_068020	COG3629	intracellular signal transduction
L3i22_068050	COG0583	DNA-binding transcription factor activity
L3i22_068070	COG0667	Aldo Keto reductase
L3i22_068080	COG0840	transmembrane signaling receptor activity
L3i22_068090	COG0667	Aldo Keto reductase
L3i22_068100	COG1309	transcriptional regulator
L3i22_068110	COG0539	negative regulation of cytoplasmic translation
L3i22_068180	COG0596	Alpha beta hydrolase
L3i22_068240	COG3629	intracellular signal transduction
L3i22_068240	COG3903	Transcriptional regulator
L3i22_068260	COG4251	negative regulation of phosphorylation
L3i22_068430	COG0784	Response regulator, receiver
L3i22_068430	COG5002	protein histidine kinase activity
L3i22_068460	COG0601	transmembrane transport
L3i22_068470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_068520	COG0697	spore germination
L3i22_068590	COG3409	Peptidoglycan-binding domain 1 protein
L3i22_068630	COG1882	Formate acetyltransferase
L3i22_068640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L3i22_068680	COG4251	negative regulation of phosphorylation
L3i22_068800	COG3012	SEC-C Motif Domain Protein
L3i22_068960	COG1522	sequence-specific DNA binding
L3i22_068970	COG0531	amino acid
L3i22_068990	COG1309	transcriptional regulator
L3i22_069010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_069020	COG0640	Transcriptional regulator
L3i22_069030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L3i22_069100	COG1132	(ABC) transporter
L3i22_069110	COG1132	(ABC) transporter
L3i22_069120	COG4172	Belongs to the ABC transporter superfamily
L3i22_069130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_069160	COG1960	acyl-CoA dehydrogenase activity
L3i22_069170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_069210	COG0277	FAD linked oxidase domain protein
L3i22_069260	COG0247	lactate metabolic process
L3i22_069260	COG0277	FAD linked oxidase domain protein
L3i22_069270	COG0456	acetyltransferase
L3i22_069290	COG0544	peptidyl-prolyl cis-trans isomerase activity
L3i22_069450	COG2226	methyltransferase
L3i22_069490	COG0673	inositol 2-dehydrogenase activity
L3i22_069500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L3i22_069510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L3i22_069520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L3i22_069560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L3i22_069570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L3i22_069580	COG0022	dehydrogenase e1 component
L3i22_069590	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3i22_069590	COG0022	dehydrogenase e1 component
L3i22_069620	COG2197	response regulator
L3i22_069630	COG4585	Histidine kinase
L3i22_069780	COG1695	Transcriptional regulator
L3i22_069840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L3i22_069930	COG1674	ftsk spoiiie
L3i22_069970	COG0464	growth
L3i22_070040	COG0515	serine threonine protein kinase
L3i22_070040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L3i22_070050	COG1595	DNA-templated transcription, initiation
L3i22_070070	COG4221	oxidoreductase activity
L3i22_070080	COG1846	Transcriptional regulator
L3i22_070080	COG1940	carbohydrate kinase activity
L3i22_070090	COG1129	ABC transporter
L3i22_070100	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_070150	COG2124	cytochrome p450
L3i22_070160	COG5001	Diguanylate cyclase
L3i22_070160	COG3300	MHYT domain
L3i22_070290	COG1404	Belongs to the peptidase S8 family
L3i22_070360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L3i22_070400	COG2197	response regulator
L3i22_070410	COG3851	Histidine kinase
L3i22_070510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L3i22_070560	COG0778	Nitroreductase
L3i22_070590	COG1349	DNA-binding transcription factor activity
L3i22_070600	COG1486	melibiose metabolic process
L3i22_070610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L3i22_070630	COG1175	transmembrane transport
L3i22_070640	COG0395	ABC-type sugar transport system, permease component
L3i22_070650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_070660	COG1819	glycosyl
L3i22_070680	COG4948	Mandelate Racemase Muconate Lactonizing
L3i22_070730	COG1609	Transcriptional regulator
L3i22_070760	COG4106	trans-aconitate 2-methyltransferase activity
L3i22_070890	COG5001	Diguanylate cyclase
L3i22_070890	COG3447	MASE1 domain protein
L3i22_070890	COG5002	protein histidine kinase activity
L3i22_070940	COG0300	oxidoreductase activity
L3i22_070950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3i22_070950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L3i22_070960	COG2267	carboxylic ester hydrolase activity
L3i22_071030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L3i22_071040	COG1215	transferase activity, transferring glycosyl groups
L3i22_071150	COG3467	pyridoxamine 5'-phosphate
L3i22_071160	COG0789	Transcriptional regulator
L3i22_071240	COG0667	Aldo Keto reductase
L3i22_071250	COG2814	Major facilitator Superfamily
L3i22_071260	COG1609	Transcriptional regulator
L3i22_071340	COG2814	Major facilitator Superfamily
L3i22_071420	COG0395	ABC-type sugar transport system, permease component
L3i22_071430	COG1175	transmembrane transport
L3i22_071440	COG1609	Transcriptional regulator
L3i22_071460	COG2721	sulfolactate sulfo-lyase activity
L3i22_071480	COG1609	Transcriptional regulator
L3i22_071500	COG0494	nUDIX hydrolase
L3i22_071510	COG0784	Response regulator, receiver
L3i22_071530	COG1278	Cold shock
L3i22_071550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L3i22_071590	COG1260	myo-inositol-1-phosphate synthase
L3i22_071790	COG2755	lipolytic protein G-D-S-L family
L3i22_071930	COG3973	AAA domain
L3i22_071930	COG3973	AAA domain
L3i22_071990	COG1116	anion transmembrane transporter activity
L3i22_072010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_072160	COG1309	transcriptional regulator
L3i22_072340	COG0154	amidase activity
L3i22_072360	COG1132	(ABC) transporter
L3i22_072530	COG1131	(ABC) transporter
L3i22_072580	COG2072	flavoprotein involved in K transport
L3i22_072590	COG1063	alcohol dehydrogenase
L3i22_072660	COG3509	depolymerase
L3i22_072690	COG2815	serine threonine protein kinase
L3i22_072690	COG0515	serine threonine protein kinase
L3i22_072700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_072710	COG0697	spore germination
L3i22_072840	COG0714	Associated with various cellular activities
L3i22_072930	COG0714	Associated with various cellular activities
L3i22_072940	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L3i22_072970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_073030	COG2259	Doxx family
L3i22_073040	COG3345	alpha-galactosidase
L3i22_073050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L3i22_073100	COG1131	(ABC) transporter
L3i22_073140	COG2814	Major facilitator Superfamily
L3i22_073160	COG0745	RESPONSE REGULATOR receiver
L3i22_073170	COG2205	protein histidine kinase activity
L3i22_073260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L3i22_073300	COG1716	ATPase activity
L3i22_073310	COG0509	glycine decarboxylation via glycine cleavage system
L3i22_073400	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
L3i22_073410	COG0384	phenazine biosynthesis protein PhzF
L3i22_073420	COG5001	Diguanylate cyclase
L3i22_073420	COG5002	protein histidine kinase activity
L3i22_073420	COG3447	MASE1 domain protein
L3i22_073430	COG0488	(ABC) transporter
L3i22_073460	COG1649	PFAM Uncharacterised BCR, COG1649
L3i22_073470	COG0297	glycogen (starch) synthase activity
L3i22_073480	COG3300	MHYT domain
L3i22_073480	COG5001	Diguanylate cyclase
L3i22_073490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L3i22_073600	COG2501	S4 domain
L3i22_073620	COG1366	Belongs to the anti-sigma-factor antagonist family
L3i22_073630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L3i22_073650	COG1940	carbohydrate kinase activity
L3i22_073660	COG4214	carbohydrate transport
L3i22_073690	COG2160	L-arabinose isomerase activity
L3i22_073700	COG1609	Transcriptional regulator
L3i22_073790	COG3706	GGDEF domain
L3i22_073800	COG5006	permease, DMT superfamily
L3i22_073810	COG1136	(ABC) transporter
L3i22_073810	COG0577	efflux transmembrane transporter activity
L3i22_073820	COG1136	(ABC) transporter
L3i22_073820	COG0577	efflux transmembrane transporter activity
L3i22_073830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L3i22_073850	COG2340	Cysteine-rich secretory protein family
L3i22_073900	COG0840	transmembrane signaling receptor activity
L3i22_073910	COG2198	Histidine kinase
L3i22_073910	COG0643	Histidine kinase
L3i22_073920	COG2201	protein-glutamate methylesterase activity
L3i22_073930	COG0745	RESPONSE REGULATOR receiver
L3i22_073950	COG1136	(ABC) transporter
L3i22_073950	COG0577	efflux transmembrane transporter activity
L3i22_073960	COG0577	efflux transmembrane transporter activity
L3i22_073960	COG1136	(ABC) transporter
L3i22_073980	COG2197	response regulator
L3i22_074140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L3i22_074150	COG2154	pterin-4-alpha-carbinolamine dehydratase
L3i22_074160	COG3119	arylsulfatase activity
L3i22_074190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L3i22_074210	COG0840	transmembrane signaling receptor activity
L3i22_074220	COG1960	acyl-CoA dehydrogenase activity
L3i22_074250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3i22_074270	COG2226	methyltransferase
L3i22_074360	COG3842	ATPase activity
L3i22_074420	COG1309	transcriptional regulator
L3i22_074460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_074470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L3i22_074480	COG1120	ATPase activity
L3i22_074490	COG0840	transmembrane signaling receptor activity
L3i22_074530	COG0579	oxidoreductase
L3i22_074540	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_074580	COG2267	carboxylic ester hydrolase activity
L3i22_074600	COG0179	Fumarylacetoacetate (FAA) hydrolase
L3i22_074630	COG0583	DNA-binding transcription factor activity
L3i22_074640	COG4213	ABC transporter substrate-binding protein
L3i22_074650	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_074660	COG1129	ABC transporter
L3i22_074720	COG0745	RESPONSE REGULATOR receiver
L3i22_074740	COG1017	nitric oxide dioxygenase activity
L3i22_074740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L3i22_074780	COG1316	TRANSCRIPTIONal
L3i22_074820	COG0477	Major facilitator Superfamily
L3i22_074840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L3i22_074890	COG2197	response regulator
L3i22_074910	COG1136	(ABC) transporter
L3i22_074910	COG0577	efflux transmembrane transporter activity
L3i22_074940	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_074960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3i22_075030	COG3629	intracellular signal transduction
L3i22_075030	COG3903	Transcriptional regulator
L3i22_075120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L3i22_075170	COG0546	phosphoglycolate phosphatase activity
L3i22_075200	COG0805	protein transport
L3i22_075210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L3i22_075230	COG2378	regulation of single-species biofilm formation
L3i22_075310	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L3i22_075320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L3i22_075330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L3i22_075350	COG4122	O-methyltransferase activity
L3i22_075370	COG1222	aaa ATPase
L3i22_075410	COG1994	Peptidase M50
L3i22_075410	COG0517	IMP dehydrogenase activity
L3i22_075430	COG2197	response regulator
L3i22_075490	COG1136	(ABC) transporter
L3i22_075490	COG0577	efflux transmembrane transporter activity
L3i22_075500	COG1136	(ABC) transporter
L3i22_075500	COG0577	efflux transmembrane transporter activity
L3i22_075630	COG2197	response regulator
L3i22_075690	COG0215	cysteine-tRNA ligase activity
L3i22_075730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_075740	COG0667	Aldo Keto reductase
L3i22_075760	COG2197	response regulator
L3i22_075790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3i22_075800	COG5592	hemerythrin HHE cation binding domain
L3i22_075820	COG0542	response to heat
L3i22_075940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L3i22_075960	COG0745	RESPONSE REGULATOR receiver
L3i22_075970	COG0653	protein targeting
L3i22_076060	COG1797	cobyrinic acid a,c-diamide synthase activity
L3i22_076110	COG2202	Pas domain
L3i22_076110	COG2200	EAL domain
L3i22_076110	COG2199	diguanylate cyclase activity
L3i22_076140	COG0708	Exodeoxyribonuclease III
L3i22_076160	COG5012	cobalamin binding
L3i22_076200	COG1643	Atp-dependent helicase
L3i22_076210	COG1316	TRANSCRIPTIONal
L3i22_076220	COG0784	Response regulator, receiver
L3i22_076230	COG4251	negative regulation of phosphorylation
L3i22_076240	COG1705	Flagellar rod assembly protein muramidase FlgJ
L3i22_076290	COG3467	pyridoxamine 5'-phosphate
L3i22_076340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L3i22_076360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L3i22_076400	COG2183	response to ionizing radiation
L3i22_076500	COG0631	protein serine/threonine phosphatase activity
L3i22_076530	COG5297	Belongs to the glycosyl hydrolase family 6
L3i22_076560	COG5001	Diguanylate cyclase
L3i22_076580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3i22_076590	COG1960	acyl-CoA dehydrogenase activity
L3i22_076600	COG0752	glycyl-tRNA synthetase alpha subunit
L3i22_076600	COG0751	glycine-tRNA ligase activity
L3i22_076620	COG2197	response regulator
L3i22_076630	COG4585	Histidine kinase
L3i22_076660	COG0584	glycerophosphoryl diester phosphodiesterase
L3i22_076710	COG1082	Xylose isomerase domain protein TIM barrel
L3i22_076750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L3i22_076770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_076790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L3i22_076800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L3i22_076850	COG5001	Diguanylate cyclase
L3i22_076860	COG3447	MASE1 domain protein
L3i22_076860	COG5002	protein histidine kinase activity
L3i22_076860	COG5001	Diguanylate cyclase
L3i22_076880	COG0515	serine threonine protein kinase
L3i22_077000	COG3866	Pectate lyase
L3i22_077020	COG0673	inositol 2-dehydrogenase activity
L3i22_077030	COG0246	Mannitol dehydrogenase
L3i22_077040	COG1904	glucuronate isomerase
L3i22_077050	COG0673	inositol 2-dehydrogenase activity
L3i22_077080	COG1175	transmembrane transport
L3i22_077090	COG0395	ABC-type sugar transport system, permease component
L3i22_077120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L3i22_077140	COG0686	Belongs to the AlaDH PNT family
L3i22_077170	COG2197	response regulator
L3i22_077180	COG4585	Histidine kinase
L3i22_077250	COG1486	melibiose metabolic process
L3i22_077270	COG0395	ABC-type sugar transport system, permease component
L3i22_077280	COG1175	transmembrane transport
L3i22_077290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L3i22_077330	COG0840	transmembrane signaling receptor activity
L3i22_077340	COG0477	Major facilitator Superfamily
L3i22_077370	COG2365	Tyrosine phosphatase family
L3i22_077420	COG1595	DNA-templated transcription, initiation
L3i22_077470	COG1653	transport
L3i22_077480	COG0395	ABC-type sugar transport system, permease component
L3i22_077490	COG0395	ABC-type sugar transport system, permease component
L3i22_077540	COG2409	Drug exporters of the RND superfamily
L3i22_077630	COG2211	Major facilitator Superfamily
L3i22_077640	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_077650	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_077660	COG1414	Transcriptional regulator
L3i22_077680	COG0179	Fumarylacetoacetate (FAA) hydrolase
L3i22_077690	COG0179	Fumarylacetoacetate (FAA) hydrolase
L3i22_077720	COG1316	TRANSCRIPTIONal
L3i22_077730	COG2160	L-arabinose isomerase activity
L3i22_077740	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_077750	COG1172	Belongs to the binding-protein-dependent transport system permease family
L3i22_077770	COG1879	ABC-type sugar transport system periplasmic component
L3i22_077790	COG1609	Transcriptional regulator
L3i22_077840	COG0235	Class ii aldolase
L3i22_077880	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L3i22_077880	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L3i22_077900	COG2130	NADP-dependent
L3i22_077910	COG1309	transcriptional regulator
L3i22_077940	COG5002	protein histidine kinase activity
L3i22_077960	COG0840	transmembrane signaling receptor activity
L3i22_078000	COG1131	(ABC) transporter
L3i22_078130	COG0583	DNA-binding transcription factor activity
L3i22_078140	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_078170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3i22_078240	COG3458	cephalosporin-C deacetylase activity
L3i22_078250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L3i22_078310	COG0840	transmembrane signaling receptor activity
L3i22_078320	COG1461	Dihydroxyacetone kinase
L3i22_078330	COG2376	Dihydroxyacetone kinase
L3i22_078340	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
L3i22_078370	COG2814	Major facilitator Superfamily
L3i22_078390	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_078410	COG0183	Belongs to the thiolase family
L3i22_078420	COG3903	Transcriptional regulator
L3i22_078420	COG3629	intracellular signal transduction
L3i22_078460	COG1960	acyl-CoA dehydrogenase activity
L3i22_078470	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_078490	COG1064	alcohol dehydrogenase
L3i22_078500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L3i22_078500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L3i22_078520	COG1476	TRANSCRIPTIONal
L3i22_078530	COG1024	Enoyl-CoA hydratase
L3i22_078540	COG5002	protein histidine kinase activity
L3i22_078570	COG3903	Transcriptional regulator
L3i22_078570	COG3629	intracellular signal transduction
L3i22_078590	COG3903	Transcriptional regulator
L3i22_078590	COG3629	intracellular signal transduction
L3i22_078610	COG3940	Belongs to the glycosyl hydrolase 43 family
L3i22_078620	COG2199	diguanylate cyclase activity
L3i22_078620	COG2200	EAL domain
L3i22_078620	COG2202	Pas domain
L3i22_078640	COG2072	flavoprotein involved in K transport
L3i22_078690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L3i22_078720	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_078750	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_078820	COG4608	Belongs to the ABC transporter superfamily
L3i22_078830	COG0444	Belongs to the ABC transporter superfamily
L3i22_078840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_078880	COG3300	MHYT domain
L3i22_078880	COG5001	Diguanylate cyclase
L3i22_078890	COG0667	Aldo Keto reductase
L3i22_078900	COG0477	Major facilitator Superfamily
L3i22_078910	COG1309	transcriptional regulator
L3i22_078920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3i22_078940	COG1086	Polysaccharide biosynthesis protein
L3i22_078950	COG3206	protein involved in exopolysaccharide biosynthesis
L3i22_078950	COG0489	protein tyrosine kinase activity
L3i22_079000	COG0438	transferase activity, transferring glycosyl groups
L3i22_079020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L3i22_079030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L3i22_079080	COG4952	isomerase
L3i22_079090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L3i22_079100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L3i22_079160	COG1309	transcriptional regulator
L3i22_079210	COG1252	NADH dehydrogenase
L3i22_079230	COG1435	thymidine kinase activity
L3i22_079250	COG0667	Aldo Keto reductase
L3i22_079270	COG1132	(ABC) transporter
L3i22_079280	COG1132	(ABC) transporter
L3i22_079290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L3i22_079310	COG2301	Belongs to the HpcH HpaI aldolase family
L3i22_079320	COG1960	acyl-CoA dehydrogenase activity
L3i22_079460	COG1960	acyl-CoA dehydrogenase activity
L3i22_079470	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_079590	COG4221	oxidoreductase activity
L3i22_079740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L3i22_079750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L3i22_079790	COG0840	transmembrane signaling receptor activity
L3i22_079840	COG3548	integral membrane protein
L3i22_079860	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_079870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L3i22_079880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L3i22_079890	COG1335	isochorismatase
L3i22_079940	COG1131	(ABC) transporter
L3i22_080040	COG1595	DNA-templated transcription, initiation
L3i22_080170	COG0395	ABC-type sugar transport system, permease component
L3i22_080190	COG1609	Transcriptional regulator
L3i22_080300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L3i22_080310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L3i22_080350	COG2814	Major facilitator Superfamily
L3i22_080390	COG4221	oxidoreductase activity
L3i22_080440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L3i22_080450	COG1213	nucleotidyl transferase
L3i22_080450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L3i22_080460	COG3608	succinylglutamate desuccinylase aspartoacylase
L3i22_080460	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L3i22_080540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L3i22_080590	COG2318	DinB family
L3i22_080620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_080670	COG1695	Transcriptional regulator
L3i22_080720	COG2188	Transcriptional regulator
L3i22_080770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L3i22_080780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L3i22_080800	COG1414	Transcriptional regulator
L3i22_080810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L3i22_080880	COG1404	Belongs to the peptidase S8 family
L3i22_080880	COG4412	M6 family metalloprotease domain protein
L3i22_080910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L3i22_081000	COG3706	GGDEF domain
L3i22_081030	COG1063	alcohol dehydrogenase
L3i22_081120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L3i22_081140	COG1086	Polysaccharide biosynthesis protein
L3i22_081150	COG0297	glycogen (starch) synthase activity
L3i22_081170	COG2197	response regulator
L3i22_081190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L3i22_081220	COG2197	response regulator
L3i22_081360	COG1175	transmembrane transport
L3i22_081370	COG1653	transport
L3i22_081380	COG1609	Transcriptional regulator
L3i22_081400	COG3706	GGDEF domain
L3i22_081450	COG4565	transcriptional regulatory protein
L3i22_081460	COG3290	protein histidine kinase activity
L3i22_081470	COG1301	dicarboxylic acid transport
L3i22_081520	COG2197	response regulator
L3i22_081530	COG4585	Histidine kinase
L3i22_081540	COG3511	phospholipase C
L3i22_081590	COG1132	(ABC) transporter
L3i22_081620	COG0076	glutamate decarboxylase activity
L3i22_081640	COG0745	RESPONSE REGULATOR receiver
L3i22_081650	COG2205	protein histidine kinase activity
L3i22_081670	COG2197	response regulator
L3i22_081700	COG0477	Major facilitator Superfamily
L3i22_081720	COG1132	(ABC) transporter
L3i22_081770	COG5479	isomerase activity
L3i22_081770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L3i22_081780	COG0515	serine threonine protein kinase
L3i22_081790	COG5002	protein histidine kinase activity
L3i22_081790	COG3447	MASE1 domain protein
L3i22_081790	COG5001	Diguanylate cyclase
L3i22_081800	COG1506	peptidase
L3i22_081800	COG4946	Tricorn protease homolog
L3i22_081800	COG0823	Involved in the tonB-independent uptake of proteins
L3i22_081830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L3i22_081840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L3i22_081890	COG2124	cytochrome p450
L3i22_081900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L3i22_081910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3i22_082070	COG3537	Alpha-1,2-mannosidase
L3i22_082130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L3i22_082140	COG1414	Transcriptional regulator
L3i22_082150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L3i22_082160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L3i22_082230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L3i22_082260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L3i22_082270	COG3158	transport of potassium into the cell
L3i22_082300	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_082310	COG1024	Enoyl-CoA hydratase
L3i22_082330	COG1960	acyl-CoA dehydrogenase activity
L3i22_082340	COG2746	aminoglycoside 3-N-acetyltransferase activity
L3i22_082360	COG3903	Transcriptional regulator
L3i22_082360	COG3629	intracellular signal transduction
L3i22_082390	COG0641	radical SAM
L3i22_082400	COG5001	Diguanylate cyclase
L3i22_082400	COG3300	MHYT domain
L3i22_082440	COG1609	Transcriptional regulator
L3i22_082470	COG2815	serine threonine protein kinase
L3i22_082470	COG0515	serine threonine protein kinase
L3i22_082640	COG0210	DNA helicase
L3i22_082660	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L3i22_082670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L3i22_082680	COG0515	serine threonine protein kinase
L3i22_082680	COG2815	serine threonine protein kinase
L3i22_082690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L3i22_082780	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L3i22_082960	COG3469	chitinase activity
L3i22_083120	COG2197	response regulator
L3i22_083140	COG4221	oxidoreductase activity
L3i22_083170	COG3104	oligopeptide transport
L3i22_083190	COG2409	Drug exporters of the RND superfamily
L3i22_083420	COG0439	Biotin carboxylase
L3i22_083450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L3i22_083490	COG2977	Belongs to the P-Pant transferase superfamily
L3i22_083530	COG0477	Major facilitator Superfamily
L3i22_083540	COG0604	alcohol dehydrogenase
L3i22_083540	COG3321	synthase
L3i22_083580	COG1673	EVE domain
L3i22_083730	COG0019	diaminopimelate decarboxylase activity
L3i22_083780	COG3321	synthase
L3i22_083780	COG0604	alcohol dehydrogenase
L3i22_083790	COG0604	alcohol dehydrogenase
L3i22_083790	COG3321	synthase
L3i22_083810	COG0604	alcohol dehydrogenase
L3i22_083810	COG3321	synthase
L3i22_083860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L3i22_083920	COG1053	succinate dehydrogenase
L3i22_083930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_083960	COG1309	transcriptional regulator
L3i22_084000	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_084020	COG1024	Enoyl-CoA hydratase
L3i22_084110	COG1960	acyl-CoA dehydrogenase activity
L3i22_084120	COG1960	acyl-CoA dehydrogenase activity
L3i22_084130	COG0183	Belongs to the thiolase family
L3i22_084140	COG2070	2-Nitropropane dioxygenase
L3i22_084190	COG0183	Belongs to the thiolase family
L3i22_084210	COG2124	cytochrome p450
L3i22_084220	COG0183	Belongs to the thiolase family
L3i22_084250	COG1960	acyl-CoA dehydrogenase activity
L3i22_084260	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_084270	COG1024	Enoyl-CoA hydratase
L3i22_084280	COG1960	acyl-CoA dehydrogenase activity
L3i22_084300	COG1960	acyl-CoA dehydrogenase activity
L3i22_084320	COG0540	Belongs to the ATCase OTCase family
L3i22_084330	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_084350	COG0028	Belongs to the TPP enzyme family
L3i22_084350	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
L3i22_084440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L3i22_084450	COG0346	lactoylglutathione lyase activity
L3i22_084460	COG2267	carboxylic ester hydrolase activity
L3i22_084470	COG1960	acyl-CoA dehydrogenase activity
L3i22_084520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L3i22_084530	COG4569	acetaldehyde dehydrogenase (acetylating) activity
L3i22_084540	COG3971	2-oxopent-4-enoate hydratase activity
L3i22_084560	COG1053	succinate dehydrogenase
L3i22_084590	COG1960	acyl-CoA dehydrogenase activity
L3i22_084600	COG1960	acyl-CoA dehydrogenase activity
L3i22_084610	COG1309	transcriptional regulator
L3i22_084660	COG3903	Transcriptional regulator
L3i22_084660	COG3629	intracellular signal transduction
L3i22_084680	COG2197	response regulator
L3i22_084700	COG3903	Transcriptional regulator
L3i22_084700	COG3629	intracellular signal transduction
L3i22_084740	COG0464	growth
L3i22_084790	COG1674	ftsk spoiiie
L3i22_084920	COG1674	ftsk spoiiie
L3i22_085000	COG0745	RESPONSE REGULATOR receiver
L3i22_085210	COG2124	cytochrome p450
L3i22_085260	COG0477	Major facilitator Superfamily
L3i22_085290	COG4770	biotin carboxylase activity
L3i22_085320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L3i22_085330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L3i22_085370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L3i22_085400	COG1268	BioY protein
L3i22_085610	COG1160	GTP binding
L3i22_085640	COG0456	acetyltransferase
L3i22_085660	COG3979	chitinase
L3i22_085730	COG0583	DNA-binding transcription factor activity
L3i22_085770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L3i22_085790	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_085880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L3i22_085890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L3i22_086070	COG0494	nUDIX hydrolase
L3i22_086080	COG0504	CTP synthase activity
L3i22_086150	COG0497	DNA recombination
L3i22_086170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L3i22_086220	COG0840	transmembrane signaling receptor activity
L3i22_086240	COG0647	UMP catabolic process
L3i22_086270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L3i22_086280	COG2326	polyphosphate kinase activity
L3i22_086300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L3i22_086320	COG1063	alcohol dehydrogenase
L3i22_086330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3i22_086340	COG2213	PTS system mannitol-specific
L3i22_086340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3i22_086350	COG2213	PTS system mannitol-specific
L3i22_086350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L3i22_086370	COG1349	DNA-binding transcription factor activity
L3i22_086390	COG0563	adenylate kinase activity
L3i22_086520	COG2094	Belongs to the DNA glycosylase MPG family
L3i22_086530	COG3973	AAA domain
L3i22_086560	COG1177	transmembrane transport
L3i22_086570	COG1176	ABC-type spermidine putrescine transport system, permease component I
L3i22_086580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L3i22_086590	COG3842	ATPase activity
L3i22_086600	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_086610	COG3835	regulator
L3i22_086670	COG3300	MHYT domain
L3i22_086670	COG5001	Diguanylate cyclase
L3i22_086680	COG0730	response to heat
L3i22_086730	COG1609	Transcriptional regulator
L3i22_086740	COG0454	-acetyltransferase
L3i22_086770	COG3833	ABC-type maltose transport systems, permease component
L3i22_086820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3i22_086830	COG0165	Argininosuccinate lyase
L3i22_086850	COG0137	argininosuccinate synthase activity
L3i22_086870	COG1438	arginine binding
L3i22_086880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L3i22_086890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L3i22_086900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L3i22_086910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L3i22_086920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L3i22_086950	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L3i22_086960	COG0121	glutamine amidotransferase
L3i22_086970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L3i22_087000	COG0456	acetyltransferase
L3i22_087010	COG2949	membrane
L3i22_087020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L3i22_087070	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_087090	COG0477	Major facilitator Superfamily
L3i22_087100	COG1335	isochorismatase
L3i22_087110	COG0072	phenylalanine-tRNA ligase activity
L3i22_087110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3i22_087120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L3i22_087130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L3i22_087140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L3i22_087150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L3i22_087160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L3i22_087180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L3i22_087190	COG0140	phosphoribosyl-ATP diphosphatase activity
L3i22_087210	COG0765	amino acid transport
L3i22_087290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L3i22_087300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3i22_087300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L3i22_087360	COG0745	RESPONSE REGULATOR receiver
L3i22_087400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L3i22_087410	COG0242	peptide deformylase activity
L3i22_087440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L3i22_087460	COG1758	RNA polymerase activity
L3i22_087470	COG0194	GDP metabolic process
L3i22_087490	COG0284	orotidine-5'-phosphate decarboxylase activity
L3i22_087500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L3i22_087510	COG0167	dihydroorotate dehydrogenase activity
L3i22_087530	COG0505	Belongs to the CarA family
L3i22_087540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L3i22_087550	COG0540	Belongs to the ATCase OTCase family
L3i22_087560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L3i22_087580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L3i22_087590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L3i22_087600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L3i22_087610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L3i22_087620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L3i22_087630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L3i22_087640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L3i22_087670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L3i22_087680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L3i22_087780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L3i22_087860	COG3964	amidohydrolase
L3i22_087870	COG0251	oxidation-reduction process
L3i22_087880	COG0515	serine threonine protein kinase
L3i22_087890	COG0515	serine threonine protein kinase
L3i22_087900	COG0831	urea catabolic process
L3i22_087910	COG0832	Belongs to the urease beta subunit family
L3i22_087920	COG0804	urea catabolic process
L3i22_087940	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L3i22_087950	COG0829	nickel cation binding
L3i22_087980	COG0515	serine threonine protein kinase
L3i22_087990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L3i22_087990	COG0189	ligase activity
L3i22_088000	COG4242	Belongs to the peptidase S51 family
L3i22_088060	COG0124	histidyl-tRNA synthetase
L3i22_088100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L3i22_088110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L3i22_088140	COG1862	Preprotein translocase
L3i22_088150	COG2255	four-way junction helicase activity
L3i22_088160	COG0632	four-way junction helicase activity
L3i22_088170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L3i22_088190	COG0217	transcriptional regulatory protein
L3i22_088200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L3i22_088210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L3i22_088230	COG0438	transferase activity, transferring glycosyl groups
L3i22_088240	COG1560	Kdo2-lipid A biosynthetic process
L3i22_088300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L3i22_088330	COG2205	protein histidine kinase activity
L3i22_088360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L3i22_088380	COG0667	Aldo Keto reductase
L3i22_088400	COG1278	Cold shock
L3i22_088490	COG1472	Belongs to the glycosyl hydrolase 3 family
L3i22_088510	COG0514	ATP-dependent DNA helicase (RecQ)
L3i22_088520	COG4106	trans-aconitate 2-methyltransferase activity
L3i22_088530	COG2197	response regulator
L3i22_088540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_088590	COG4585	Histidine kinase
L3i22_088610	COG1131	(ABC) transporter
L3i22_088620	COG0438	transferase activity, transferring glycosyl groups
L3i22_088690	COG0668	transmembrane transport
L3i22_088760	COG0542	response to heat
L3i22_088780	COG2309	aminopeptidase activity
L3i22_088820	COG2197	response regulator
L3i22_088830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L3i22_088850	COG4266	Belongs to the allantoicase family
L3i22_088860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L3i22_088910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L3i22_088940	COG2351	hydroxyisourate hydrolase activity
L3i22_088960	COG1643	Atp-dependent helicase
L3i22_089070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L3i22_089180	COG2202	Pas domain
L3i22_089180	COG2205	protein histidine kinase activity
L3i22_089190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L3i22_089210	COG0405	Gamma-glutamyltransferase
L3i22_089230	COG2133	pyrroloquinoline quinone binding
L3i22_089320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3i22_089330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_089350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L3i22_089430	COG1686	Belongs to the peptidase S11 family
L3i22_089480	COG3973	AAA domain
L3i22_089500	COG1191	sigma factor activity
L3i22_089510	COG0513	Belongs to the DEAD box helicase family
L3i22_089570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L3i22_089580	COG1609	Transcriptional regulator
L3i22_089590	COG0747	negative chemotaxis
L3i22_089610	COG0601	transmembrane transport
L3i22_089620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_089630	COG0444	Belongs to the ABC transporter superfamily
L3i22_089640	COG2723	6-phospho-beta-galactosidase activity
L3i22_089700	COG1846	Transcriptional regulator
L3i22_089710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L3i22_089720	COG0187	DNA topoisomerase II activity
L3i22_089740	COG2197	response regulator
L3i22_089770	COG2205	protein histidine kinase activity
L3i22_089780	COG0745	RESPONSE REGULATOR receiver
L3i22_089810	COG0435	Glutathione S-transferase
L3i22_089830	COG1846	Transcriptional regulator
L3i22_089840	COG0697	spore germination
L3i22_089870	COG0714	Associated with various cellular activities
L3i22_089900	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L3i22_089910	COG2314	TM2 domain
L3i22_090070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L3i22_090150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L3i22_090160	COG0543	2 iron, 2 sulfur cluster binding
L3i22_090160	COG0633	Ferredoxin
L3i22_090230	COG0395	ABC-type sugar transport system, permease component
L3i22_090240	COG1175	transmembrane transport
L3i22_090280	COG2755	lipolytic protein G-D-S-L family
L3i22_090310	COG0515	serine threonine protein kinase
L3i22_090330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L3i22_090350	COG1136	(ABC) transporter
L3i22_090410	COG3135	benzoate transporter
L3i22_090450	COG0436	Aminotransferase
L3i22_090460	COG2197	response regulator
L3i22_090470	COG4585	Histidine kinase
L3i22_090480	COG1131	(ABC) transporter
L3i22_090610	COG1653	transport
L3i22_090630	COG2936	dipeptidyl-peptidase activity
L3i22_090650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L3i22_090660	COG0601	transmembrane transport
L3i22_090770	COG2318	DinB family
L3i22_090800	COG0671	phosphoesterase, PA-phosphatase related
L3i22_090820	COG1597	lipid kinase activity
L3i22_090890	COG0745	RESPONSE REGULATOR receiver
L3i22_090920	COG2197	response regulator
L3i22_091060	COG0800	Aldolase
L3i22_091080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_091120	COG0366	Alpha amylase catalytic
L3i22_091130	COG0438	transferase activity, transferring glycosyl groups
L3i22_091140	COG0438	transferase activity, transferring glycosyl groups
L3i22_091190	COG0673	inositol 2-dehydrogenase activity
L3i22_091240	COG0366	Alpha amylase catalytic
L3i22_091250	COG0395	ABC-type sugar transport system, permease component
L3i22_091260	COG1175	transmembrane transport
L3i22_091290	COG0840	transmembrane signaling receptor activity
L3i22_091300	COG3012	SEC-C Motif Domain Protein
L3i22_091310	COG3483	tryptophan 2,3-dioxygenase activity
L3i22_091350	COG0659	secondary active sulfate transmembrane transporter activity
L3i22_091370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L3i22_091370	COG2308	Evidence 4 Homologs of previously reported genes of
L3i22_091380	COG0367	asparagine synthase
L3i22_091390	COG1506	peptidase
L3i22_091400	COG0542	response to heat
L3i22_091440	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L3i22_091480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L3i22_091490	COG0561	phosphatase activity
L3i22_091600	COG2197	response regulator
L3i22_091610	COG4585	Histidine kinase
L3i22_091650	COG1131	(ABC) transporter
L3i22_091660	COG0328	RNA-DNA hybrid ribonuclease activity
L3i22_091710	COG1672	PFAM Archaeal ATPase
L3i22_091710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L3i22_091790	COG1309	transcriptional regulator
L3i22_091820	COG3285	dna ligase
L3i22_091820	COG1793	dna ligase
L3i22_091840	COG4585	Histidine kinase
L3i22_091850	COG2197	response regulator
L3i22_091860	COG5001	Diguanylate cyclase
L3i22_091920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L3i22_091940	COG1595	DNA-templated transcription, initiation
L3i22_092020	COG0438	transferase activity, transferring glycosyl groups
L3i22_092030	COG0438	transferase activity, transferring glycosyl groups
L3i22_092100	COG4638	Rieske (2fe-2S)
L3i22_092150	COG0517	IMP dehydrogenase activity
L3i22_092150	COG4175	Glycine betaine
L3i22_092170	COG0584	glycerophosphoryl diester phosphodiesterase
L3i22_092200	COG2807	transmembrane transport
L3i22_092240	COG4249	Peptidase C14 caspase catalytic subunit p20
L3i22_092240	COG2319	Wd-40 repeat
L3i22_092260	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_092290	COG1609	Transcriptional regulator
L3i22_092330	COG0395	ABC-type sugar transport system, permease component
L3i22_092360	COG1609	Transcriptional regulator
L3i22_092400	COG0058	SHG alpha-glucan phosphorylase activity
L3i22_092470	COG0823	Involved in the tonB-independent uptake of proteins
L3i22_092510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L3i22_092520	COG4585	Histidine kinase
L3i22_092530	COG2197	response regulator
L3i22_092540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L3i22_092590	COG1960	acyl-CoA dehydrogenase activity
L3i22_092600	COG4941	Belongs to the sigma-70 factor family
L3i22_092630	COG0657	acetylesterase activity
L3i22_092720	COG4106	trans-aconitate 2-methyltransferase activity
L3i22_092820	COG1024	Enoyl-CoA hydratase
L3i22_092830	COG1024	Enoyl-CoA hydratase
L3i22_092840	COG3424	synthase
L3i22_092910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L3i22_092920	COG2423	ornithine cyclodeaminase activity
L3i22_092960	COG1024	Enoyl-CoA hydratase
L3i22_093000	COG2304	oxidoreductase activity
L3i22_093010	COG2304	oxidoreductase activity
L3i22_093030	COG0714	Associated with various cellular activities
L3i22_093040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3i22_093110	COG5002	protein histidine kinase activity
L3i22_093130	COG1477	protein flavinylation
L3i22_093190	COG3300	MHYT domain
L3i22_093190	COG5001	Diguanylate cyclase
L3i22_093300	COG0395	ABC-type sugar transport system, permease component
L3i22_093310	COG1175	transmembrane transport
L3i22_093320	COG1653	transport
L3i22_093330	COG1609	Transcriptional regulator
L3i22_093360	COG1960	acyl-CoA dehydrogenase activity
L3i22_093370	COG5001	Diguanylate cyclase
L3i22_093420	COG2197	response regulator
L3i22_093460	COG0604	alcohol dehydrogenase
L3i22_093460	COG3321	synthase
L3i22_093470	COG2409	Drug exporters of the RND superfamily
L3i22_093490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L3i22_093530	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_093570	COG2264	protein methyltransferase activity
L3i22_093600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L3i22_093610	COG0156	8-amino-7-oxononanoate synthase activity
L3i22_093620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L3i22_093680	COG0420	3'-5' exonuclease activity
L3i22_093690	COG0419	ATPase involved in DNA repair
L3i22_093820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L3i22_093910	COG1793	dna ligase
L3i22_093970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L3i22_093990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L3i22_094000	COG0655	NAD(P)H dehydrogenase (quinone) activity
L3i22_094030	COG3253	May function as heme-dependent peroxidase
L3i22_094040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L3i22_094050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L3i22_094070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3i22_094080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L3i22_094090	COG0183	Belongs to the thiolase family
L3i22_094100	COG1250	3-hydroxyacyl-CoA dehydrogenase
L3i22_094100	COG1024	Enoyl-CoA hydratase
L3i22_094120	COG2205	protein histidine kinase activity
L3i22_094130	COG0745	RESPONSE REGULATOR receiver
L3i22_094170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L3i22_094180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L3i22_094190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L3i22_094200	COG0531	amino acid
L3i22_094210	COG0569	domain protein
L3i22_094260	COG0756	dUTP diphosphatase activity
L3i22_094340	COG3706	GGDEF domain
L3i22_094360	COG2860	membrane
L3i22_094380	COG2313	pseudouridylate synthase activity
L3i22_094480	COG0643	Histidine kinase
L3i22_094480	COG2198	Histidine kinase
L3i22_094490	COG0835	chemotaxis
L3i22_094510	COG1490	D-aminoacyl-tRNA deacylase activity
L3i22_094550	COG0123	including yeast histone deacetylase and acetoin utilization protein
L3i22_094600	COG0738	Major facilitator superfamily
L3i22_094620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L3i22_094630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L3i22_094640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L3i22_094660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L3i22_094680	COG2826	transposase and inactivated derivatives, IS30 family
L3i22_094700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L3i22_094710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L3i22_094720	COG1196	nuclear chromosome segregation
L3i22_094810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L3i22_094830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L3i22_094850	COG1126	abc transporter atp-binding protein
L3i22_094860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L3i22_094870	COG0765	amino acid transport
L3i22_094880	COG0765	amino acid transport
L3i22_094890	COG1418	mRNA catabolic process
L3i22_094900	COG2137	regulation of response to DNA damage stimulus
L3i22_094910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L3i22_094930	COG1573	uracil-dna glycosylase
L3i22_094970	COG0515	serine threonine protein kinase
L3i22_094970	COG2815	serine threonine protein kinase
L3i22_094980	COG1201	RNA secondary structure unwinding
L3i22_095020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L3i22_095040	COG1842	Phage shock protein A
L3i22_095050	COG1396	sequence-specific DNA binding
L3i22_095060	COG1546	Belongs to the CinA family
L3i22_095060	COG1058	Belongs to the CinA family
L3i22_095080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L3i22_095110	COG1674	ftsk spoiiie
L3i22_095150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L3i22_095160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L3i22_095180	COG3214	Protein conserved in bacteria
L3i22_095210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L3i22_095230	COG0612	Peptidase, M16
L3i22_095240	COG1185	polyribonucleotide nucleotidyltransferase activity
L3i22_095250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L3i22_095280	COG5002	protein histidine kinase activity
L3i22_095280	COG0784	Response regulator, receiver
L3i22_095280	COG2198	Histidine kinase
L3i22_095290	COG3300	MHYT domain
L3i22_095290	COG5001	Diguanylate cyclase
L3i22_095300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L3i22_095330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L3i22_095340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L3i22_095370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L3i22_095400	COG0779	Required for maturation of 30S ribosomal subunits
L3i22_095470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L3i22_095480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L3i22_095500	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_095510	COG0174	glutamine synthetase
L3i22_095530	COG1668	transmembrane transport
L3i22_095540	COG4152	abc transporter atp-binding protein
L3i22_095550	COG2197	response regulator
L3i22_095600	COG1309	transcriptional regulator
L3i22_095610	COG1511	domain protein
L3i22_095640	COG0640	Transcriptional regulator
L3i22_095670	COG0456	acetyltransferase
L3i22_095680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L3i22_095690	COG0750	zinc metalloprotease
L3i22_095740	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L3i22_095740	COG2146	nitrite reductase [NAD(P)H] activity
L3i22_095770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L3i22_095790	COG0233	cytoplasmic translational termination
L3i22_095800	COG0528	UMP kinase activity
L3i22_095810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L3i22_095820	COG0052	Belongs to the universal ribosomal protein uS2 family
L3i22_095840	COG0792	nuclease activity
L3i22_095900	COG2188	Transcriptional regulator
L3i22_095940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L3i22_095950	COG0494	nUDIX hydrolase
L3i22_095960	COG0681	Belongs to the peptidase S26 family
L3i22_095970	COG0681	Belongs to the peptidase S26 family
L3i22_095980	COG0335	large ribosomal subunit rRNA binding
L3i22_095990	COG0336	Belongs to the RNA methyltransferase TrmD family
L3i22_096000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L3i22_096010	COG1837	Belongs to the UPF0109 family
L3i22_096020	COG0228	four-way junction DNA binding
L3i22_096030	COG0442	prolyl-tRNA aminoacylation
L3i22_096040	COG1595	DNA-templated transcription, initiation
L3i22_096100	COG0438	transferase activity, transferring glycosyl groups
L3i22_096130	COG0463	Glycosyl transferase, family 2
L3i22_096150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L3i22_096150	COG2755	lipolytic protein G-D-S-L family
L3i22_096220	COG1216	Glycosyl transferase, family 2
L3i22_096230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L3i22_096290	COG2318	DinB family
L3i22_096350	COG0438	transferase activity, transferring glycosyl groups
L3i22_096380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L3i22_096400	COG0571	ribonuclease III activity
L3i22_096450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L3i22_096460	COG0742	ribosomal rna small subunit methyltransferase
L3i22_096510	COG1461	Dihydroxyacetone kinase
L3i22_096520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L3i22_096580	COG1181	Belongs to the D-alanine--D-alanine ligase family
L3i22_096610	COG0626	cystathionine gamma-synthase activity
L3i22_096620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L3i22_096640	COG1920	GTP binding
L3i22_096660	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L3i22_096690	COG0776	regulation of translation
L3i22_096700	COG0066	3-isopropylmalate dehydratase activity
L3i22_096750	COG0179	Fumarylacetoacetate (FAA) hydrolase
L3i22_096760	COG1476	TRANSCRIPTIONal
L3i22_096780	COG1131	(ABC) transporter
L3i22_096820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L3i22_096830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L3i22_096880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L3i22_096890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L3i22_096900	COG0473	3-isopropylmalate dehydrogenase activity
L3i22_096930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L3i22_096940	COG0440	acetolactate synthase activity
L3i22_096960	COG5001	Diguanylate cyclase
L3i22_096960	COG3300	MHYT domain
L3i22_096970	COG0129	dihydroxy-acid dehydratase activity
L3i22_097010	COG2132	Multicopper oxidase
L3i22_097020	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_097020	COG3321	synthase
L3i22_097020	COG0604	alcohol dehydrogenase
L3i22_097050	COG1609	Transcriptional regulator
L3i22_097080	COG2133	pyrroloquinoline quinone binding
L3i22_097110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L3i22_097130	COG0154	amidase activity
L3i22_097140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L3i22_097160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L3i22_097180	COG0482	sulfurtransferase activity
L3i22_097200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L3i22_097220	COG2149	membrane
L3i22_097300	COG0840	transmembrane signaling receptor activity
L3i22_097310	COG0840	transmembrane signaling receptor activity
L3i22_097320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L3i22_097330	COG1119	ATPase activity
L3i22_097350	COG1472	Belongs to the glycosyl hydrolase 3 family
L3i22_097370	COG2902	Dehydrogenase
L3i22_097390	COG0010	Belongs to the arginase family
L3i22_097440	COG0300	oxidoreductase activity
L3i22_097450	COG0183	Belongs to the thiolase family
L3i22_097460	COG0346	lactoylglutathione lyase activity
L3i22_097530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L3i22_097560	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
L3i22_097590	COG1674	ftsk spoiiie
L3i22_097610	COG1250	3-hydroxyacyl-CoA dehydrogenase
L3i22_097650	COG0346	lactoylglutathione lyase activity
L3i22_097680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L3i22_097700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L3i22_097710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L3i22_097720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L3i22_097730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L3i22_097740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L3i22_097750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L3i22_097760	COG0356	it plays a direct role in the translocation of protons across the membrane
L3i22_097790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L3i22_097800	COG0702	epimerase
L3i22_097810	COG0009	L-threonylcarbamoyladenylate synthase
L3i22_097840	COG2890	protein-(glutamine-N5) methyltransferase activity
L3i22_097870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L3i22_097880	COG0254	rRNA binding
L3i22_097930	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L3i22_097950	COG0083	homoserine kinase activity
L3i22_097970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L3i22_097990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L3i22_098010	COG0460	homoserine dehydrogenase
L3i22_098030	COG0018	arginyl-trna synthetase
L3i22_098060	COG0681	Belongs to the peptidase S26 family
L3i22_098070	COG0525	valine-tRNA ligase activity
L3i22_098110	COG3979	chitinase
L3i22_098130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L3i22_098150	COG0515	serine threonine protein kinase
L3i22_098150	COG2815	serine threonine protein kinase
L3i22_098190	COG1733	regulation of RNA biosynthetic process
L3i22_098270	COG0673	inositol 2-dehydrogenase activity
L3i22_098310	COG0754	glutathionylspermidine amidase activity
L3i22_098330	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_098370	COG0586	Pfam SNARE associated Golgi protein
L3i22_098420	COG3469	chitinase activity
L3i22_098480	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L3i22_098510	COG0740	serine-type endopeptidase activity
L3i22_098530	COG1834	amidinotransferase
L3i22_098540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L3i22_098600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3i22_098630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3i22_098640	COG2205	protein histidine kinase activity
L3i22_098650	COG0745	RESPONSE REGULATOR receiver
L3i22_098680	COG0508	dehydrogenase complex catalyzes the overall conversion of
L3i22_098680	COG0567	Dehydrogenase, E1 component
L3i22_098700	COG0280	phosphate acetyltransferase
L3i22_098700	COG0857	belongs to the CobB CobQ family
L3i22_098710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L3i22_098770	COG2172	sigma factor antagonist activity
L3i22_098780	COG2188	Transcriptional regulator
L3i22_098800	COG1597	lipid kinase activity
L3i22_098840	COG0175	sulfate reduction
L3i22_098860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L3i22_098890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L3i22_098910	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L3i22_098930	COG1595	DNA-templated transcription, initiation
L3i22_098960	COG2135	peptidase activity
L3i22_098970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L3i22_098980	COG1162	GTPase activity
L3i22_098990	COG0483	inositol monophosphate 1-phosphatase activity
L3i22_099140	COG1357	PFAM Pentapeptide repeats (8 copies)
L3i22_099180	COG1846	Transcriptional regulator
L3i22_099200	COG1396	sequence-specific DNA binding
L3i22_099230	COG1615	UPF0182 protein
L3i22_099240	COG3480	Lon protease (S16) C-terminal proteolytic domain
L3i22_099300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L3i22_099370	COG2816	NAD+ diphosphatase activity
L3i22_099400	COG1959	2 iron, 2 sulfur cluster binding
L3i22_099420	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L3i22_099470	COG1278	Cold shock
L3i22_099500	COG1074	ATP-dependent DNA helicase activity
L3i22_099510	COG1611	Belongs to the LOG family
L3i22_099520	COG1611	Belongs to the LOG family
L3i22_099540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L3i22_099550	COG2171	N-acyltransferase activity
L3i22_099590	COG2226	methyltransferase
L3i22_099650	COG4221	oxidoreductase activity
L3i22_099700	COG0456	acetyltransferase
L3i22_099730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L3i22_099740	COG1506	peptidase
L3i22_099740	COG0823	Involved in the tonB-independent uptake of proteins
L3i22_099780	COG1053	succinate dehydrogenase
L3i22_099830	COG0477	Major facilitator Superfamily
L3i22_099940	COG1960	acyl-CoA dehydrogenase activity
L3i22_100010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L3i22_100040	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_100180	COG0012	GTP binding
L3i22_100220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L3i22_100220	COG2169	Transcriptional regulator
L3i22_100230	COG0525	valine-tRNA ligase activity
L3i22_100270	COG1322	Protein conserved in bacteria
L3i22_100280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L3i22_100310	COG1570	exodeoxyribonuclease VII activity
L3i22_100320	COG1722	exodeoxyribonuclease VII activity
L3i22_100370	COG0705	Rhomboid family
L3i22_100400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L3i22_100410	COG1877	trehalose-phosphatase activity
L3i22_100410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L3i22_100420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L3i22_100430	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L3i22_100510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L3i22_100540	COG0515	serine threonine protein kinase
L3i22_100540	COG2815	serine threonine protein kinase
L3i22_100580	COG0424	maF-like protein
L3i22_100600	COG4770	biotin carboxylase activity
L3i22_100710	COG1473	amidohydrolase
L3i22_100710	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L3i22_100720	COG2815	serine threonine protein kinase
L3i22_100720	COG0515	serine threonine protein kinase
L3i22_100730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L3i22_100750	COG1216	Glycosyl transferase, family 2
L3i22_100760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L3i22_100780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L3i22_100820	COG1215	transferase activity, transferring glycosyl groups
L3i22_100830	COG0673	inositol 2-dehydrogenase activity
L3i22_100840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L3i22_100850	COG0438	transferase activity, transferring glycosyl groups
L3i22_100880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L3i22_100900	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_100910	COG1012	belongs to the aldehyde dehydrogenase family
L3i22_100970	COG2018	Roadblock/LC7 domain
L3i22_100990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L3i22_101040	COG1079	Belongs to the binding-protein-dependent transport system permease family
L3i22_101050	COG4603	Belongs to the binding-protein-dependent transport system permease family
L3i22_101060	COG3845	ABC transporter
L3i22_101070	COG1744	ABC transporter substrate-binding protein PnrA-like
L3i22_101120	COG0180	Tryptophanyl-tRNA synthetase
L3i22_101130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L3i22_101140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L3i22_101180	COG1218	3'(2'),5'-bisphosphate nucleotidase
L3i22_101190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L3i22_101200	COG0193	aminoacyl-tRNA hydrolase activity
L3i22_101210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L3i22_101230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L3i22_101240	COG1309	transcriptional regulator
L3i22_101260	COG0488	(ABC) transporter
L3i22_101270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L3i22_101280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L3i22_101290	COG0084	hydrolase, TatD family'
L3i22_101320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L3i22_101420	COG0303	'Molybdopterin
L3i22_101430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L3i22_101540	COG2095	MarC family integral membrane protein
L3i22_101550	COG0613	PHP domain protein
L3i22_101600	COG3118	belongs to the thioredoxin family
L3i22_101630	COG1028	Short-chain dehydrogenase reductase Sdr
L3i22_101660	COG1011	Hydrolase
L3i22_101680	COG0384	phenazine biosynthesis protein PhzF
L3i22_101690	COG2239	Acts as a magnesium transporter
L3i22_101720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L3i22_101730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L3i22_101750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L3i22_101780	COG1024	Enoyl-CoA hydratase
L3i22_101800	COG0519	Catalyzes the synthesis of GMP from XMP
L3i22_101830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L3i22_101840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L3i22_101840	COG0674	pyruvate-flavodoxin oxidoreductase activity
L3i22_101850	COG1013	pyruvate-flavodoxin oxidoreductase activity
L3i22_101910	COG0113	porphobilinogen synthase activity
L3i22_101930	COG0181	hydroxymethylbilane synthase activity
L3i22_101940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L3i22_101950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L3i22_101980	COG0318	PFAM AMP-dependent synthetase and ligase
L3i22_101990	COG1595	DNA-templated transcription, initiation
L3i22_102050	COG0506	proline dehydrogenase activity
L3i22_102070	COG1082	Xylose isomerase domain protein TIM barrel
L3i22_102120	COG0588	phosphoglycerate mutase activity
L3i22_102160	COG0438	transferase activity, transferring glycosyl groups
L3i22_102190	COG0745	RESPONSE REGULATOR receiver
L3i22_102220	COG5002	protein histidine kinase activity
L3i22_102250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L3i22_102260	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
L3i22_102280	COG4786	Flagellar basal body rod
L3i22_102280	COG1256	bacterial-type flagellum assembly
L3i22_102300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L3i22_102340	COG1815	bacterial-type flagellum-dependent cell motility
L3i22_102360	COG1677	Flagellar hook-basal body complex protein FliE
L3i22_102380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L3i22_102400	COG1157	protein secretion by the type III secretion system
L3i22_102420	COG0741	lytic transglycosylase activity
L3i22_102460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L3i22_102470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L3i22_102490	COG1338	Plays a role in the flagellum-specific transport system
L3i22_102510	COG1776	CheC inhibitor of MCP methylation
L3i22_102510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L3i22_102520	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L3i22_102540	COG1360	Flagellar Motor Protein
L3i22_102550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L3i22_102570	COG1749	Flagellar hook protein flgE
L3i22_102600	COG0745	RESPONSE REGULATOR receiver
L3i22_102640	COG2201	protein-glutamate methylesterase activity
L3i22_102670	COG0643	Histidine kinase
L3i22_102670	COG0784	Response regulator, receiver
L3i22_102670	COG2198	Histidine kinase
L3i22_102680	COG0745	RESPONSE REGULATOR receiver
L3i22_102700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L3i22_102830	COG3246	L-lysine catabolic process to acetate
L3i22_102850	COG0735	belongs to the Fur family
L3i22_102870	COG4044	May play a role in the intracellular transport of hydrophobic ligands
L3i22_102900	COG1051	belongs to the nudix hydrolase family
L3i22_102930	COG1595	DNA-templated transcription, initiation
L3i22_102990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L3i22_103020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L3i22_103030	COG0456	acetyltransferase
L3i22_103040	COG0745	RESPONSE REGULATOR receiver
L3i22_103110	COG2339	peptidase activity
L3i22_103120	COG4129	membrane
L3i22_103190	COG0459	protein refolding
L3i22_103220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L3i22_103250	COG1131	(ABC) transporter
L3i22_103270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3i22_103300	COG1131	(ABC) transporter
L3i22_103310	COG1349	DNA-binding transcription factor activity
L3i22_103440	COG3842	ATPase activity
L3i22_103490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L3i22_103500	COG0215	cysteine-tRNA ligase activity
L3i22_103520	COG0114	fumarate hydratase activity
L3i22_103530	COG3903	Transcriptional regulator
L3i22_103530	COG3629	intracellular signal transduction
L3i22_103550	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L3i22_103550	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L3i22_103580	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L3i22_103600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L3i22_103680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L3i22_103700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L3i22_103750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L3i22_103780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L3i22_103790	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
L3i22_103820	COG1194	a g-specific adenine glycosylase
L3i22_103890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L3i22_103900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L3i22_103920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L3i22_103940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L3i22_103950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L3i22_103980	COG0649	NAD binding
L3i22_104010	COG1174	glycine betaine transport
L3i22_104020	COG1174	glycine betaine transport
L3i22_104090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L3i22_104100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L3i22_104160	COG0741	lytic transglycosylase activity
L3i22_104160	COG0739	heme binding
L3i22_104160	COG1196	nuclear chromosome segregation
L3i22_104180	COG1674	ftsk spoiiie
L3i22_104210	COG0302	gtp cyclohydrolase
L3i22_104220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L3i22_104230	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L3i22_104240	COG0037	tRNA processing
L3i22_104260	COG2027	D-alanyl-D-alanine carboxypeptidase
L3i22_104280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L3i22_104300	COG1674	ftsk spoiiie
L3i22_104340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L3i22_104350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L3i22_104420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L3i22_104470	COG0003	Pfam Anion-transporting ATPase
L3i22_104500	COG1610	YqeY-like protein
L3i22_104510	COG1408	metallophosphoesterase
L3i22_104530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L3i22_104570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L3i22_104610	COG4608	Belongs to the ABC transporter superfamily
L3i22_104620	COG0444	Belongs to the ABC transporter superfamily
L3i22_104660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L3i22_104720	COG0813	purine-nucleoside phosphorylase activity
L3i22_104770	COG0287	Prephenate dehydrogenase
L3i22_104780	COG2318	DinB family
L3i22_104790	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L3i22_104790	COG0235	Class ii aldolase
L3i22_104820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L3i22_104820	COG1796	DNA polymerase
L3i22_104850	COG0642	Histidine kinase
L3i22_104910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L3i22_104960	COG3979	chitinase
L3i22_105110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L3i22_105150	COG2205	protein histidine kinase activity
L3i22_105240	COG1268	BioY protein
L3i22_105260	COG0667	Aldo Keto reductase
L3i22_105290	COG1131	(ABC) transporter
L3i22_105310	COG1595	DNA-templated transcription, initiation
L3i22_105350	COG0673	inositol 2-dehydrogenase activity
L3i22_105380	COG0464	growth
L3i22_105440	COG1695	Transcriptional regulator
L3i22_105450	COG1674	ftsk spoiiie
L3i22_105540	COG0243	molybdopterin cofactor binding
L3i22_105600	COG0297	glycogen (starch) synthase activity
L3i22_105620	COG0438	transferase activity, transferring glycosyl groups
L3i22_105640	COG0438	transferase activity, transferring glycosyl groups
L3i22_105680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L3i22_105690	COG1435	thymidine kinase activity
L3i22_105710	COG0443	Heat shock 70 kDa protein
L3i22_105880	COG3979	chitinase
L3i22_105890	COG2199	diguanylate cyclase activity
L3i22_105890	COG2200	EAL domain
L3i22_105920	COG0148	phosphopyruvate hydratase activity
L3i22_106030	COG0242	peptide deformylase activity
L3i22_106070	COG1881	PFAM PEBP family protein
L3i22_106130	COG0789	Transcriptional regulator
L3i22_106140	COG3959	Transketolase, thiamine diphosphate binding domain
L3i22_106150	COG3958	Transketolase
L3i22_106220	COG0598	Magnesium transport protein CorA
L3i22_106230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_106250	COG0371	Dehydrogenase
L3i22_106290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L3i22_106310	COG3275	phosphorelay sensor kinase activity
L3i22_106330	COG0745	RESPONSE REGULATOR receiver
L3i22_106340	COG2205	protein histidine kinase activity
L3i22_106370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L3i22_106420	COG2188	Transcriptional regulator
L3i22_106460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L3i22_106470	COG1316	TRANSCRIPTIONal
L3i22_106600	COG1764	response to oxidative stress
L3i22_106620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L3i22_106630	COG0561	phosphatase activity
L3i22_106640	COG0561	phosphatase activity
L3i22_106660	COG1834	amidinotransferase
L3i22_106670	COG1522	sequence-specific DNA binding
L3i22_106710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L3i22_106750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L3i22_106780	COG1408	metallophosphoesterase
L3i22_106870	COG0521	Mo-molybdopterin cofactor biosynthetic process
L3i22_106870	COG0315	cyclic pyranopterin monophosphate synthase activity
L3i22_106880	COG0315	cyclic pyranopterin monophosphate synthase activity
L3i22_106890	COG5001	Diguanylate cyclase
L3i22_106960	COG0359	binds to the 23S rRNA
L3i22_106970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L3i22_106980	COG0629	single-stranded DNA binding
L3i22_106990	COG0360	Binds together with S18 to 16S ribosomal RNA
L3i22_107040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L3i22_107070	COG1695	Transcriptional regulator
L3i22_107160	COG0617	tRNA 3'-terminal CCA addition
L3i22_107200	COG1595	DNA-templated transcription, initiation
L3i22_107220	COG0492	ferredoxin-NADP+ reductase activity
L3i22_107230	COG3118	belongs to the thioredoxin family
L3i22_107240	COG0860	N-Acetylmuramoyl-L-alanine amidase
L3i22_107240	COG3409	Peptidoglycan-binding domain 1 protein
L3i22_107260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L3i22_107280	COG1181	Belongs to the D-alanine--D-alanine ligase family
L3i22_107330	COG1192	Involved in chromosome partitioning
L3i22_107340	COG0357	Ribosomal RNA small subunit methyltransferase G
L3i22_107360	COG0706	membrane insertase activity
L3i22_107370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L3i22_107380	COG0594	ribonuclease P activity
L3i22_107390	COG0230	Belongs to the bacterial ribosomal protein bL34 family