locus-tag class description L083_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) L083_0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) L083_0005 ENOG4105K7N UPF0232 protein L083_0007 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) L083_0009 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) L083_0018 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase L083_0019 ENOG4105E09 nadh pyrophosphatase L083_0029 ENOG4105CJ1 ABC, transporter L083_0034 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase L083_0035 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase L083_0036 ENOG4107QX3 carboxylase L083_0037 ENOG4105C1G acyl-Coa dehydrogenase L083_0039 ENOG41090MY MarR family Transcriptional regulator L083_0040 ENOG4108YYC ycei family L083_0048 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family L083_0050 ENOG4105TV9 FHA Domain-Containing protein L083_0050 ENOG4105TV9 FHA Domain-Containing protein L083_0051 ENOG4105HZM Fha domain containing protein L083_0054 ENOG4105CJN penicillin-binding protein L083_0055 ENOG4107TPY serine threonine protein kinase L083_0056 ENOG4105D9P serine threonine protein kinase L083_0058 ENOG4105DF6 Fe-S oxidoreductase L083_0059 ENOG4105ZJT Cell division protein CrgA L083_0075 ENOG4105DHP deoxycytidine triphosphate deaminase L083_0078 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) L083_0081 ENOG4105CSU acyl-Coa dehydrogenase L083_0083 ENOG4105M4E phosphohistidine phosphatase, SixA L083_0085 ENOG4105ECR NmrA family L083_0092 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 L083_0093 ENOG4105CPP Dehydrogenase, E1 component L083_0100 ENOG4105CFG Acts as a chaperone (By similarity) L083_0102 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ L083_0103 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) L083_0104 ENOG4105KNI merR family transcriptional Regulator L083_0106 ENOG4105CKD glutathione-regulated potassium-efflux system protein L083_0109 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit L083_0113 ENOG4107YCR Transcriptional regulator, ARSR family L083_0114 ENOG4105DQR SNARE associated Golgi L083_0115 ENOG4107S1Q Phosphatase L083_0124 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis L083_0125 ENOG4105C12 Phosphoribosylglycinamide synthetase L083_0129 ENOG4105C83 adenylosuccinate lyase L083_0130 ENOG4105DND Transcriptional regulator L083_0132 ENOG410839H phosphoribosylformylglycinamidine synthase L083_0133 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I L083_0134 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii L083_0139 ENOG4105CXB phosphoribosylaminoimidazole synthetase L083_0141 ENOG4105VUF Transcriptional regulator L083_0148 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) L083_0152 ENOG4105KA0 thioesterase Superfamily protein L083_0159 ENOG4107SCK Monooxygenase L083_0165 ENOG4105VTR Integrase L083_0168 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) L083_0171 ENOG4105CVP deoxyribo-dipyrimidine photolyase L083_0178 ENOG4105CQB FAD linked oxidase domain protein L083_0182 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) L083_0183 ENOG4105ENE Histidine kinase L083_0185 ENOG4108KDT Molybdate metabolism regulator L083_0186 ENOG4105KKX ATPase associated with various cellular activities aaa_5 L083_0187 ENOG4105WH1 Two component transcriptional regulator luxr family L083_0188 ENOG4105RD5 L083_0189 ENOG4105DEG Vwa containing coxe family protein L083_0190 ENOG410903U zinc ion binding L083_0223 ENOG4105EQ0 Major Facilitator superfamily L083_0235 ENOG4105CHR reductase L083_0237 ENOG4105CPC Aldo Keto reductase L083_0238 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase L083_0243 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) L083_0247 ENOG4105RHA ABC transporter, permease L083_0248 ENOG4108IUX (ABC) transporter L083_0250 ENOG4105CJA serine threonine protein kinase L083_0257 ENOG4105C0A alcohol dehydrogenase L083_0258 ENOG4105C8Y Acetylornithine aminotransferase L083_0267 ENOG4107QVM von Willebrand factor, type A L083_0270 ENOG4105C7R Atpase associated with various cellular activities aaa_3 L083_0282 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_0283 ENOG4105BZU Histidine kinase L083_0284 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase L083_0286 ENOG4105FUA antagonist L083_0287 ENOG4107MMM Anti-sigma-factor antagonist L083_0289 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) L083_0301 ENOG4105NAE bifunctional deaminase-reductase domain protein L083_0302 ENOG4105NAE bifunctional deaminase-reductase domain protein L083_0304 ENOG4105BZU Histidine kinase L083_0305 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase L083_0307 ENOG4108Q5F Tetr family transcriptional regulator L083_0308 ENOG4105WN5 stage II sporulation protein L083_0309 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase L083_0310 ENOG4108RH7 phosphoglycerate mutase L083_0311 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen L083_0312 ENOG4107QIV Cytochrome c biogenesis protein L083_0313 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) L083_0314 ENOG4105CRE cytochrome C L083_0315 ENOG4105KVH Transcriptional regulator L083_0318 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) L083_0322 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase L083_0324 ENOG4108VVK transcriptional Regulator, AsnC L083_0328 ENOG4105C1J atp-dependent rna helicase L083_0395 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) L083_0396 ENOG4105ZXU NLP P60 protein L083_0397 ENOG4105DVY radical SAM domain protein L083_0402 ENOG4105EEM helicase L083_0405 ENOG4105EV6 Pfam:DUF178 L083_0407 ENOG4105ERR inositol mono-phosphatase L083_0410 ENOG4105CPC Aldo Keto reductase L083_0412 ENOG4107XWB Zinc finger, swim domain protein L083_0413 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) L083_0414 ENOG4105C0D helicase L083_0415 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_0419 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0420 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain L083_0421 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0423 ENOG4107QIZ NADH dehydrogenase L083_0424 ENOG4108IEH NADH dehydrogenase subunit g L083_0425 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) L083_0426 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0427 ENOG4105DF2 NADH dehydrogenase subunit j L083_0428 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0431 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0434 ENOG4107HP6 Transcriptional regulator L083_0438 ENOG41082T9 Membrane L083_0443 ENOG4105D74 hydrolase L083_0445 ENOG4107G87 m6 family metalloprotease domain protein L083_0446 ENOG4107G87 m6 family metalloprotease domain protein L083_0447 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) L083_0460 ENOG4105WN5 stage II sporulation protein L083_0461 ENOG4108I5C dEAD DEAH box helicase L083_0463 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for L083_0466 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) L083_0468 ENOG4108SGK Tetr family transcriptional regulator L083_0470 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) L083_0471 ENOG4105C6E dna polymerase iii L083_0476 ENOG4105MA4 psp1 domain protein L083_0497 ENOG4108Z0Z intracellular protease Pfpi family L083_0499 ENOG41062IR nudix hydrolase L083_0500 ENOG4105FDF Could be involved in DNA repair (By similarity) L083_0501 ENOG4105DQE DNA ligase L083_0502 ENOG4105DQE DNA ligase L083_0505 ENOG4105CFI type iii restriction protein res subunit L083_0509 ENOG4105VEQ Cold shock protein L083_0510 ENOG4108UIH futalosine nucleosidase L083_0511 ENOG4105E63 Pfam:DUF178 L083_0513 ENOG4108N0W Major Facilitator superfamily L083_0515 ENOG4105C7N Xanthine uracil vitamin C permease L083_0516 ENOG4105K56 Transcriptional regulator L083_0517 ENOG4107SFI Major Facilitator superfamily L083_0518 ENOG4107YCY Transcriptional regulator L083_0519 ENOG4105DJ2 Major Facilitator Superfamily L083_0523 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) L083_0525 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) L083_0527 ENOG4107WI4 Aldose-1-epimerase L083_0530 ENOG4105C1G acyl-Coa dehydrogenase L083_0535 ENOG4105FDK ABC transporter L083_0537 ENOG4105BZU Histidine kinase L083_0538 ENOG4105WH1 Two component transcriptional regulator luxr family L083_0541 ENOG4105K64 Glycosyl transferase, family 2 L083_0542 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) L083_0548 ENOG4107S5I aldo keto reductase L083_0553 ENOG4105EY8 ABC transporter L083_0559 ENOG4105BZU Histidine kinase L083_0574 ENOG4105CNN ABC, transporter L083_0575 ENOG4107R9N ABC transporter L083_0576 ENOG4105C2J ABC transporter L083_0577 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator L083_0593 ENOG4105EC2 ftsk spoIIIe L083_0597 ENOG4106F1P AAA ATPase, central domain protein L083_0598 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) L083_0602 ENOG4105WH1 Two component transcriptional regulator luxr family L083_0607 ENOG4105BZU Histidine kinase L083_0608 ENOG4105ETX regulatoR L083_0611 ENOG4105CJ1 ABC, transporter L083_0614 ENOG4107TY6 Acylneuraminate cytidylyltransferase L083_0617 ENOG4105C5E polysaccharide biosynthesis protein L083_0618 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase L083_0620 ENOG4105CHR reductase L083_0621 ENOG4105CEY Amp-dependent synthetase and ligase L083_0624 ENOG4105CKK Glycosyl transferase, family 2 L083_0632 ENOG4105BZU Histidine kinase L083_0633 ENOG4107QRS glycosyltransferase group 2 family protein L083_0639 ENOG41083YR Protein CrcB homolog L083_0640 ENOG41083TI Protein CrcB homolog L083_0644 ENOG4105BZU Histidine kinase L083_0649 ENOG4105CPQ Dehydrogenase L083_0654 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_0660 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_0665 ENOG4105CTS PTS system mannitol-specific L083_0666 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) L083_0668 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) L083_0669 ENOG4105VSH 4-oxalocrotonate tautomerase L083_0670 ENOG4105CYX Short-chain dehydrogenase reductase Sdr L083_0676 ENOG4105BZU Histidine kinase L083_0687 ENOG4107T5V SNARE associated Golgi L083_0689 ENOG4105DQE DNA ligase L083_0691 ENOG4105DQ4 alcohol dehydrogenase L083_0701 ENOG4105DTD Dehydrogenase L083_0702 ENOG4105CPC Aldo Keto reductase L083_0705 ENOG4105BZU Histidine kinase L083_0707 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) L083_0714 ENOG4105EGE secreted protein L083_0715 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator L083_0716 ENOG4105CNN ABC, transporter L083_0717 ENOG4105C2J ABC transporter L083_0719 ENOG4105CF7 AraC family transcriptional regulator L083_0724 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) L083_0725 ENOG4107QR9 Iron-sulfur cluster binding protein L083_0726 ENOG41080R8 Conserved Protein L083_0728 ENOG4107S5I aldo keto reductase L083_0732 ENOG4107QK4 glycoside hydrolase, family 3 domain protein L083_0735 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) L083_0736 ENOG4105GRZ Ycii-related protein L083_0737 ENOG4105CHP RNA polymerase L083_0738 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) L083_0739 ENOG4105D0M Protease HtpX homolog L083_0740 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) L083_0741 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) L083_0742 ENOG4106A3M Cytochrome p-450 L083_0743 ENOG4107RTD sua5 ycio yrdc ywlc family protein L083_0776 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) L083_0783 ENOG4105BZU Histidine kinase L083_0784 ENOG4105BZU Histidine kinase L083_0794 ENOG41088YS Glycosyl transferase (Group 1 L083_0795 ENOG4108SHN Glycosyl transferase, family 2 L083_0803 ENOG4105DPZ Two component transcriptional regulator (Winged helix family L083_0804 ENOG4105BZU Histidine kinase L083_0810 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component L083_0813 ENOG4105ETE Transcriptional regulator (LacI family L083_0818 ENOG4107RSM transcriptional regulator L083_0822 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) L083_0823 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F L083_0824 ENOG4107HP6 Transcriptional regulator L083_0828 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) L083_0829 ENOG4105EDW glycosyl transferase, family 39 L083_0830 ENOG4105BZU Histidine kinase L083_0831 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_0832 ENOG4106A3M Cytochrome p-450 L083_0840 ENOG4105EEX Two component transcriptional regulator (Winged helix family L083_0841 ENOG4105BZU Histidine kinase L083_0843 ENOG4108MWI inositol mono-phosphatase L083_0844 ENOG4108R85 Short chain dehydrogenase L083_0847 ENOG4105D9P serine threonine protein kinase L083_0848 ENOG410865Q Potassium uptake protein L083_0849 ENOG4105CZN Potassium uptake protein L083_0851 ENOG4105C9U ATP-dependent DNA helicase RecQ L083_0852 ENOG4105K4H Nlp p60 protein L083_0853 ENOG4105VPX protein, conserved in bacteria L083_0856 ENOG4105EWN Heme oxygenase L083_0858 ENOG4105C1J atp-dependent rna helicase L083_0862 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) L083_0868 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) L083_0870 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) L083_0873 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0877 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0879 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) L083_0881 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0883 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_0885 ENOG4105C8S subunit m L083_0887 ENOG4105D0M Protease HtpX homolog L083_0890 ENOG41090XM Early upstream open reading frame L083_0891 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr L083_0892 ENOG4107QVI Methyltransferase, type 11 L083_0894 ENOG4105DEN Luciferase family L083_0903 ENOG4108VPT UPF0234 protein L083_0906 ENOG4105BZU Histidine kinase L083_0907 ENOG4105WDJ 50S ribosomal protein L33 L083_0908 ENOG410900P UPF0336 protein L083_0912 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) L083_0913 ENOG4108VZM 50s ribosomal protein L10 L083_0914 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) L083_0915 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) L083_0916 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) L083_0919 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) L083_0920 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) L083_0921 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) L083_0922 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) L083_0923 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) L083_0924 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) L083_0925 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) L083_0926 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) L083_0927 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity L083_0928 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) L083_0929 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) L083_0930 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) L083_0931 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) L083_0932 ENOG41082SA 50s ribosomal protein l29 L083_0933 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal L083_0934 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) L083_0935 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) L083_0936 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits L083_0937 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) L083_0938 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) L083_0939 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) L083_0940 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) L083_0941 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) L083_0942 ENOG410849U 50S ribosomal protein L30 L083_0943 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) L083_0944 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) L083_0945 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) L083_0949 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) L083_0950 ENOG41067V7 50S ribosomal protein L36 L083_0951 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits L083_0952 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) L083_0953 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) L083_0955 ENOG4108ZT0 50S ribosomal protein l17 L083_0956 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) L083_0957 ENOG4105CHR reductase L083_0960 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) L083_0963 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) L083_0965 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) L083_0966 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) L083_0968 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) L083_0973 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component L083_0976 ENOG4105GWZ Roadblock lc7 family protein L083_0980 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) L083_0981 ENOG4108UJD 30S ribosomal protein S9 L083_0982 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) L083_0984 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) L083_0988 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) L083_0990 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) L083_0992 ENOG4108097 ATP-binding protein L083_0993 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) L083_0995 ENOG4105KEG ribosomal-protein-alanine acetyltransferase L083_0996 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) L083_0998 ENOG4105BZ1 (ABC) transporter L083_0999 ENOG4105BZ1 (ABC) transporter L083_1004 ENOG4108HWW ABC transporter L083_1005 ENOG4105C2J ABC transporter L083_1006 ENOG4105DFW ABC transporter L083_1007 ENOG4108Z66 YbaK ebsC protein L083_1010 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) L083_1013 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) L083_1014 ENOG4105WH1 Two component transcriptional regulator luxr family L083_1016 ENOG4108VT4 L083_1022 ENOG4108KGH TRANSCRIPTIONal L083_1025 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) L083_1027 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) L083_1028 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) L083_1029 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase L083_1030 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme L083_1035 ENOG4105DEF Extracellular solute-binding protein, family 5 L083_1036 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component L083_1037 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component L083_1038 ENOG4105C3U ABC transporter L083_1039 ENOG4108JQ7 (ABC) transporter L083_1040 ENOG4106D2I Chorismate mutase L083_1043 ENOG4108K5P (LipO)protein L083_1045 ENOG4105DR5 peptidase L083_1047 ENOG4105CMV Succinyl-CoA synthetase subunit beta L083_1051 ENOG4105DC1 bifunctional purine biosynthesis protein purh L083_1058 ENOG4105MVE transcriptional regulator L083_1069 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) L083_1078 ENOG4105DA5 (ABC) transporter L083_1080 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) L083_1082 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) L083_1089 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) L083_1100 ENOG4105C7R Atpase associated with various cellular activities aaa_3 L083_1107 ENOG4105CHU acetyl-coa acetyltransferase L083_1118 ENOG4105CSR polyphosphate kinase 2 L083_1119 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) L083_1122 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) L083_1127 ENOG4105C7B Threonine dehydratase L083_1128 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) L083_1130 ENOG4105T1M mycothiol conjugate amidase mca L083_1134 ENOG4105C7Z Conserved Protein L083_1139 ENOG4105C6Y Udp-glucose 6-dehydrogenase L083_1142 ENOG4108S4H thioesterase Superfamily protein L083_1143 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) L083_1148 ENOG4105CJT Mannose-1-phosphate guanylyltransferase L083_1150 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) L083_1151 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase L083_1155 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) L083_1156 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) L083_1161 ENOG4107RR1 TRANSCRIPTIONal L083_1162 ENOG4105C26 Dehydrogenase L083_1166 ENOG4107QKV phosphomannomutase L083_1167 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) L083_1170 ENOG4105EIP mannose-6-phosphate isomerase L083_1173 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_1174 ENOG4105BZU Histidine kinase L083_1177 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea L083_1178 ENOG4105D9U N-acetyltransferase L083_1180 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving L083_1188 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) L083_1189 ENOG4105CAK Cell division ATP-binding protein ftsE L083_1191 ENOG4105E4C Lytic transglycosylase catalytic L083_1192 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) L083_1198 ENOG4105CGH 5'-nucleotidase L083_1199 ENOG4108UJU UPF0301 protein L083_1202 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) L083_1203 ENOG4108WYP Transcriptional regulator L083_1213 ENOG4105D7Q type ii secretion system L083_1214 ENOG4105CZX twitching motility protein L083_1215 ENOG4107QHF type ii secretion system protein e L083_1222 ENOG4105BZU Histidine kinase L083_1238 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase L083_1242 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease L083_1246 ENOG4105JAB phenazine biosynthesis protein, phzf family L083_1249 ENOG4105FQP Beta-lactamase L083_1251 ENOG4105ECQ AraC Family Transcriptional Regulator L083_1253 ENOG4105BZU Histidine kinase L083_1259 ENOG4105C5X domain protein L083_1262 ENOG4105DQE DNA ligase L083_1264 ENOG41061H0 Monooxygenase L083_1265 ENOG4105BZ9 Cytochrome C oxidase, subunit I L083_1269 ENOG4108RWI nicotinamidase L083_1270 ENOG4107RKP Nicotinate phosphoribosyltransferase L083_1271 ENOG4105PFC Transcriptional regulator L083_1272 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) L083_1273 ENOG4108FN7 Aldo keto reductase L083_1278 ENOG4108RQ5 Beta-lactamase domain-containing protein L083_1279 ENOG4108MJN Glycosyl Transferase L083_1280 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) L083_1281 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) L083_1284 ENOG4105CHP RNA polymerase L083_1286 ENOG4105C84 Histidine ammonia-lyase L083_1287 ENOG4105CI2 imidazolone-5-propionate hydrolase L083_1288 ENOG4105CI2 imidazolone-5-propionate hydrolase L083_1289 ENOG4105CE7 Amidase, hydantoinase carbamoylase family L083_1290 ENOG4105CGP Urocanate hydratase L083_1293 ENOG4105QVC MOSC domain-containing protein L083_1296 ENOG4108NVR Methyl-accepting chemotaxis L083_1307 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) L083_1309 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) L083_1311 ENOG4107T94 Endo-14-beta-xylanase L083_1312 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_1318 ENOG4108Q50 Histidine kinase L083_1331 ENOG4107UBC ErfK ybiS ycfS ynhG family protein L083_1338 ENOG4105BZ4 penicillin-binding protein L083_1348 ENOG4105F7P transcriptional regulator AsnC family L083_1352 ENOG4105RHY Pfam:UPF0157 L083_1353 ENOG4107QUT magnesium and cobalt transport protein CorA L083_1357 ENOG41082BM Transcriptional regulator, arsr family L083_1360 ENOG4105E2D ec 3.2.1.52 L083_1374 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) L083_1376 ENOG41068WN L083_1382 ENOG4105CG3 alpha amylase, catalytic region L083_1383 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) L083_1390 ENOG4105CHR reductase L083_1393 ENOG4105K4H Nlp p60 protein L083_1394 ENOG4105WX6 Membrane L083_1404 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) L083_1405 ENOG4108VB1 regulatoR L083_1408 ENOG4108JQ1 Dehydrogenase L083_1421 ENOG4105VHU single-stranded DNA-binding protein L083_1422 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) L083_1423 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) L083_1425 ENOG4105D0M Protease HtpX homolog L083_1426 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) L083_1429 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) L083_1433 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) L083_1437 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) L083_1438 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) L083_1440 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase L083_1449 ENOG4105D8X mechanosensitive ion channel L083_1459 ENOG4108YZG isomerase L083_1465 ENOG4105F0K SARP family transcriptional regulator L083_1468 ENOG4105CYX Short-chain dehydrogenase reductase Sdr L083_1470 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) L083_1476 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) L083_1477 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_1478 ENOG4105CPF Cell wall formation (By similarity) L083_1480 ENOG4108URH decarboxylase L083_1482 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_1486 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase L083_1489 ENOG4105CAY ferredoxin--nadp reductase L083_1492 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) L083_1493 ENOG4108HHA Transketolase L083_1494 ENOG4107TYG Oxidoreductase domain-containing protein L083_1498 ENOG4105CM2 brancheD-chain amino acid aminotransferase L083_1499 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation L083_1500 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) L083_1501 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) L083_1502 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) L083_1506 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) L083_1507 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase L083_1510 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) L083_1513 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein L083_1515 ENOG4107R6F Alpha Beta Hydrolase Fold protein L083_1516 ENOG4108Q50 Histidine kinase L083_1517 ENOG41084GC stage II sporulation protein L083_1520 ENOG4105C03 ribonuclease L083_1522 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) L083_1523 ENOG4105K46 50S ribosomal protein l27 L083_1524 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control L083_1530 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) L083_1531 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) L083_1532 ENOG4105CVJ phosphoglycerate mutase L083_1534 ENOG4105EPR degv family L083_1537 ENOG4105KQC Competence protein L083_1538 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 L083_1541 ENOG4105ECP epimerase L083_1546 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) L083_1550 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) L083_1551 ENOG4105Y3U Transglycosylase-associated protein L083_1554 ENOG4106YT9 Enoyl-CoA hydratase L083_1557 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) L083_1558 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) L083_1560 ENOG4108X0B nad(p)h dehydrogenase (quinone) L083_1562 ENOG4105DQ5 transport system permease protein L083_1563 ENOG4105TVJ transport system, permease L083_1564 ENOG4105E0A ABC, transporter L083_1567 ENOG4105BZ1 (ABC) transporter L083_1573 ENOG4105BZ9 Cytochrome C oxidase, subunit I L083_1575 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) L083_1580 ENOG4105CPC Aldo Keto reductase L083_1583 ENOG410836F Transposase L083_1583 ENOG410836F Transposase L083_1586 ENOG4107QK4 glycoside hydrolase, family 3 domain protein L083_1590 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) L083_1592 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) L083_1596 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) L083_1597 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) L083_1604 ENOG4108YYC ycei family L083_1610 ENOG4105CPT Alpha beta hydrolase L083_1616 ENOG4108JJB ABC transporter L083_1617 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein L083_1623 ENOG4105DIK (ABC) transporter L083_1628 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) L083_1630 ENOG4105BZU Histidine kinase L083_1642 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family L083_1652 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein L083_1653 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) L083_1655 ENOG4105CJ1 ABC, transporter L083_1657 ENOG4105HAC ABC-2 type transporter L083_1660 ENOG4107S2Z UPF0761 membrane protein L083_1662 ENOG4105C2J ABC transporter L083_1663 ENOG4105CNN ABC, transporter L083_1675 ENOG4107RSM transcriptional regulator L083_1690 ENOG4108WRK Transcriptional regulator L083_1704 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase L083_1708 ENOG4105DT9 hydrolase family 43 L083_1718 ENOG4105C8Q Methyl-accepting chemotaxis L083_1721 ENOG4105C75 arginyL-tRNA synthetase L083_1727 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) L083_1728 ENOG4107ZYJ bioY protein L083_1731 ENOG4105C7R Atpase associated with various cellular activities aaa_3 L083_1739 ENOG4105CGH 5'-nucleotidase L083_1741 ENOG4107TPY serine threonine protein kinase L083_1745 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) L083_1749 ENOG4105EEM helicase L083_1751 ENOG4108V9Q carbonic anhydrase L083_1755 ENOG4105D17 glycoside hydrolase, family 3 domain protein L083_1760 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) L083_1761 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) L083_1768 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) L083_1771 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_1773 ENOG4105C8Q Methyl-accepting chemotaxis L083_1774 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) L083_1775 ENOG4107ZED Uncharacterised protein family UPF0047 L083_1782 ENOG4107S46 esterase, PHB depolymerase L083_1786 ENOG4105E8G Major facilitator Superfamily L083_1790 ENOG4105WH1 Two component transcriptional regulator luxr family L083_1794 ENOG4105C3M thioredoxin reductase L083_1798 ENOG4105EGD dinuclear metal center protein, YbgI family L083_1800 ENOG4105CVJ phosphoglycerate mutase L083_1812 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) L083_1813 ENOG4108KXH Ybak prolyl-tRNA synthetase associated L083_1817 ENOG4105WH1 Two component transcriptional regulator luxr family L083_1818 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) L083_1819 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase L083_1822 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP L083_1823 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) L083_1824 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) L083_1825 ENOG4105C7B Threonine dehydratase L083_1829 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) L083_1831 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_1838 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) L083_1839 ENOG4105C4K Nad synthetase L083_1840 ENOG4105C5F glutamine synthetase L083_1841 ENOG4105P3N Membrane L083_1842 ENOG4105KEG ribosomal-protein-alanine acetyltransferase L083_1844 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) L083_1846 ENOG4107JC6 Membrane L083_1847 ENOG41072RD Membrane L083_1849 ENOG4105KVH Transcriptional regulator L083_1853 ENOG4105CF7 AraC family transcriptional regulator L083_1854 ENOG4105CPC Aldo Keto reductase L083_1856 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) L083_1857 ENOG4105C5S asparaginyl-tRNA synthetase L083_1858 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) L083_1866 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) L083_1867 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) L083_1868 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) L083_1869 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) L083_1871 ENOG4107XZ0 Peptidase M50 L083_1872 ENOG4105CPC Aldo Keto reductase L083_1877 ENOG4108IUW ABC transporter L083_1879 ENOG4108UMN azlc family L083_1882 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) L083_1883 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) L083_1889 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) L083_1890 ENOG4105C3J Cysteine desulfurase L083_1891 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) L083_1892 ENOG4108ZRS Part of cytochrome c oxidase, its function is L083_1896 ENOG4108I0Q anthranilate phosphoribosyltransferase L083_1900 ENOG4107UDY cytochrome C L083_1902 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) L083_1906 ENOG4108S0S Nucleotidyl transferase L083_1907 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) L083_1908 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) L083_1912 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 L083_1913 ENOG4105JNK Glycosyl transferase (Group 1 L083_1918 ENOG4105H3G oxidoreductase L083_1920 ENOG4105DKQ ROK family L083_1924 ENOG4105WH1 Two component transcriptional regulator luxr family L083_1925 ENOG4108YYH Nadph-dependent fmn reductase L083_1936 ENOG4105II7 pyrroline-5-carboxylate reductase L083_1939 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase L083_1943 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) L083_1947 ENOG4105EMY transcriptional regulator L083_1950 ENOG4105E33 succinate dehydrogenase L083_1959 ENOG4105EAH synthase L083_1965 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) L083_1970 ENOG4107QJZ Glycosyl transferase, family 2 L083_1979 ENOG4105EEX Two component transcriptional regulator (Winged helix family L083_1986 ENOG4105CHR reductase L083_1992 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) L083_1994 ENOG4107VJY DNA polymerase L083_2000 ENOG4105C7R Atpase associated with various cellular activities aaa_3 L083_2001 ENOG4105C8T Leucyl-tRNA synthetase L083_2002 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase L083_2003 ENOG4105W1N transcriptional regulator L083_2007 ENOG4105F1K Glutamine amidotransferase L083_2008 ENOG4105DFU Cell wall formation (By similarity) L083_2009 ENOG4105K4H Nlp p60 protein L083_2010 ENOG4108V6E Cell division protein mraZ L083_2011 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) L083_2013 ENOG4105CJN penicillin-binding protein L083_2016 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) L083_2018 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) L083_2019 ENOG4105DFU Cell wall formation (By similarity) L083_2021 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) L083_2022 ENOG4105DFA alanine racemase domain protein L083_2024 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) L083_2026 ENOG4107VQS DivIVA family L083_2029 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) L083_2031 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) L083_2035 ENOG4105C0B DNA polymerase III (alpha subunit) L083_2036 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) L083_2037 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) L083_2038 ENOG4105CIH Imidazole acetol-phosphate transaminase L083_2039 ENOG4105ECC imidazole-glycerol-phosphate dehydratase L083_2041 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) L083_2043 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase L083_2044 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) L083_2045 ENOG41062D9 Histidine kinase L083_2046 ENOG4105ETX regulatoR L083_2048 ENOG4108DEF Globin L083_2050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family L083_2052 ENOG4108IQE Amp-dependent synthetase and ligase L083_2053 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin L083_2055 ENOG41065SU Two-component system sensor kinase L083_2056 ENOG4108KXV response regulator L083_2060 ENOG4105BZ1 (ABC) transporter L083_2061 ENOG4105BZ1 (ABC) transporter L083_2062 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) L083_2065 ENOG4105EJ2 Transcriptional regulator L083_2066 ENOG4108FN7 Aldo keto reductase L083_2072 ENOG4105EE1 crotonyl-CoA reductase L083_2080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase L083_2081 ENOG4105CRQ synthase (Component I) L083_2083 ENOG4105CPC Aldo Keto reductase L083_2086 ENOG4105DK0 Indole-3-glycerol phosphate synthase L083_2087 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) L083_2088 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) L083_2089 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) L083_2092 ENOG4105CBC glutamate synthase L083_2103 ENOG4105C29 acyl-CoA thioesterase L083_2109 ENOG4105C32 Amino acid ABC transporter (Permease) L083_2110 ENOG4105CF8 branched-chain amino acid ABC transporter, permease L083_2111 ENOG4105C0Z ABC transporter L083_2112 ENOG4108IV0 ABC, transporter L083_2113 ENOG4107R0W ABC transporter L083_2114 ENOG4105EAD ABC transporter L083_2115 ENOG4105CDA abc transporter atp-binding protein L083_2122 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_2123 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) L083_2125 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) L083_2129 ENOG4105CI3 gtp-binding protein typa L083_2131 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) L083_2132 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) L083_2133 ENOG4105C5X domain protein L083_2135 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) L083_2137 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) L083_2139 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) L083_2140 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) L083_2142 ENOG4105CIE May be required for sporulation (By similarity) L083_2143 ENOG4105CHR reductase L083_2144 ENOG4107RSM transcriptional regulator L083_2145 ENOG4106UW1 Major Facilitator superfamily L083_2147 ENOG4108RZE Tetr family transcriptional regulator L083_2148 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase L083_2149 ENOG4105BZA Phosphoglycerate kinase L083_2150 ENOG4105CP7 Triose-phosphate isomerase L083_2153 ENOG4108ZBR Gcn5-related n-acetyltransferase L083_2158 ENOG41061H0 Monooxygenase L083_2164 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) L083_2167 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) L083_2170 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) L083_2176 ENOG4105JRK feS assembly protein SufD L083_2178 ENOG4105C3K feS assembly ATPase SufC L083_2179 ENOG4105C9B Cysteine desulfurase L083_2180 ENOG4108UNV SUF system FeS assembly protein, NifU family L083_2181 ENOG4105VG1 fes assembly suf system protein L083_2182 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) L083_2191 ENOG4105W1Y Transcriptional regulator L083_2192 ENOG4105CHH sulfate transporter L083_2193 ENOG4105BZ1 (ABC) transporter L083_2196 ENOG4105C5H ABC transporter L083_2200 ENOG4105CHR reductase L083_2202 ENOG4108VCA G U mismatch-specific DNA glycosylase L083_2205 ENOG4105E18 UPF0276 protein L083_2207 ENOG4108Q5F Tetr family transcriptional regulator L083_2215 ENOG4107QM5 aconitate hydratase L083_2229 ENOG4107T6F Xaa-Pro aminopeptidase L083_2233 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) L083_2239 ENOG4105C7R Atpase associated with various cellular activities aaa_3 L083_2247 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH L083_2249 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) L083_2252 ENOG4105W1N transcriptional regulator L083_2256 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) L083_2257 ENOG4108UF8 L083_2267 ENOG4105C87 Aminotransferase class I and II L083_2268 ENOG4108YYQ gCN5-related N-acetyltransferase L083_2276 ENOG4105C26 Dehydrogenase L083_2277 ENOG41062BK proline dehydrogenase L083_2283 ENOG410783G L083_2284 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) L083_2289 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component L083_2296 ENOG41061H0 Monooxygenase L083_2299 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) L083_2303 ENOG4105K56 Transcriptional regulator L083_2305 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) L083_2306 ENOG4105WH1 Two component transcriptional regulator luxr family L083_2307 ENOG4105BZU Histidine kinase L083_2313 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) L083_2318 ENOG4105C8Y Acetylornithine aminotransferase L083_2324 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) L083_2331 ENOG4107TE1 transport protein L083_2338 ENOG4107TE5 Lipid kinase L083_2343 ENOG4105CEY Amp-dependent synthetase and ligase L083_2349 ENOG4108KPJ rna polymerase sigma factor L083_2353 ENOG4107R13 MMPL domain protein L083_2355 ENOG4108IG5 Transcriptional regulator L083_2356 ENOG4105U6C Alpha beta hydrolase fold protein L083_2369 ENOG4105CPC Aldo Keto reductase L083_2372 ENOG4107RRE RNA-directed DNA polymerase L083_2376 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_2377 ENOG4105BZU Histidine kinase L083_2379 ENOG4105C22 threonyL-tRNA synthetase L083_2381 ENOG4108Z6Z Transcriptional regulator L083_2384 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) L083_2385 ENOG4105CHM Aminotransferase L083_2388 ENOG4105DPZ Two component transcriptional regulator (Winged helix family L083_2391 ENOG4107QJZ Glycosyl transferase, family 2 L083_2399 ENOG410841Q phosphoesterase PA-phosphatase related protein L083_2411 ENOG4105C7R Atpase associated with various cellular activities aaa_3 L083_2417 ENOG4105EGE secreted protein L083_2422 ENOG4105CYX Short-chain dehydrogenase reductase Sdr L083_2423 ENOG4108IG5 Transcriptional regulator L083_2425 ENOG4105K5B UPF0225 protein L083_2428 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) L083_2429 ENOG4105WEF catalase L083_2430 ENOG4105FDF Could be involved in DNA repair (By similarity) L083_2434 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) L083_2438 ENOG4105F0K SARP family transcriptional regulator L083_2441 ENOG4105WH1 Two component transcriptional regulator luxr family L083_2449 ENOG4106YKD Cytochrome p-450 L083_2451 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_2464 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) L083_2468 ENOG4106UW1 Major Facilitator superfamily L083_2469 ENOG4105E98 transcriptional regulator DeoR family L083_2481 ENOG4105TMB Formate nitrite transporter L083_2490 ENOG4107EEY synthase L083_2491 ENOG4107EEY synthase L083_2498 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase L083_2499 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) L083_2500 ENOG4105C1G acyl-Coa dehydrogenase L083_2502 ENOG4108JA1 polyketide synthase L083_2503 ENOG4105CEY Amp-dependent synthetase and ligase L083_2505 ENOG4105EYF MMPL domain protein L083_2506 ENOG4105DXX methyltransferase L083_2509 ENOG4108WQH regulatoR L083_2514 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr L083_2521 ENOG4105BZU Histidine kinase L083_2528 ENOG4106NZI LysR family Transcriptional regulator L083_2529 ENOG4108KEZ Dehydrogenase L083_2531 ENOG4105E7U AraC family transcriptional regulator L083_2532 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) L083_2536 ENOG4105EGE secreted protein L083_2540 ENOG4108X07 Tetr family transcriptional regulator L083_2558 ENOG4105C7B Threonine dehydratase L083_2562 ENOG4105KVH Transcriptional regulator L083_2573 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) L083_2576 ENOG4108KQ5 Integrase catalytic subunit L083_2584 ENOG4105EC2 ftsk spoIIIe L083_2589 ENOG4108KQ5 Integrase catalytic subunit L083_2614 ENOG4105CYP glycoside hydrolase, family L083_2615 ENOG4105EX0 alpha-galactosidase L083_2620 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component L083_2621 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component L083_2622 ENOG4105XN3 extracellular solute-binding protein family 1 L083_2623 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) L083_2625 ENOG4107QK4 glycoside hydrolase, family 3 domain protein L083_2631 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone L083_2634 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase L083_2637 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) L083_2640 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) L083_2655 ENOG4105CEY Amp-dependent synthetase and ligase L083_2656 ENOG4105C9B Cysteine desulfurase L083_2663 ENOG4105DXI Major Facilitator superfamily L083_2665 ENOG4107EPK O-methyltransferase, family 2 L083_2669 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) L083_2670 ENOG4105PDP Short chain dehydrogenase L083_2673 ENOG4107S9F NmrA family L083_2674 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein L083_2680 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component L083_2682 ENOG4105FKQ transcriptional regulator L083_2684 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic L083_2705 ENOG4105D9P serine threonine protein kinase L083_2708 ENOG4105F0K SARP family transcriptional regulator L083_2714 ENOG4105ETX regulatoR L083_2715 ENOG4105BZU Histidine kinase L083_2718 ENOG4108VQR secreted hydrolase L083_2722 ENOG4108KPJ rna polymerase sigma factor L083_2723 ENOG4105D74 hydrolase L083_2725 ENOG4107U32 Beta-lactamase domain protein L083_2733 ENOG4105E1F short-chain dehydrogenase reductase L083_2735 ENOG41061TZ Short-chain dehydrogenase reductase Sdr L083_2737 ENOG4108JQ1 Dehydrogenase L083_2738 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) L083_2739 ENOG4105EMU Dehydrogenase L083_2743 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component L083_2744 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component L083_2751 ENOG4105E2D ec 3.2.1.52 L083_2758 ENOG4105EEQ Na H antiporter L083_2761 ENOG4105BZP glycoside hydrolase 15-related L083_2762 ENOG4105CPQ Dehydrogenase L083_2764 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) L083_2772 ENOG4108J9M Transporter L083_2775 ENOG4107TPY serine threonine protein kinase L083_2776 ENOG4107TPY serine threonine protein kinase L083_2780 ENOG4105CSU acyl-Coa dehydrogenase L083_2784 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) L083_2785 ENOG4105CIR epoxide hydrolase L083_2789 ENOG4105KVH Transcriptional regulator L083_2791 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_2793 ENOG4105EB3 Histidine kinase L083_2794 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_2795 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_2798 ENOG4107ZQV short-chain dehydrogenase reductase L083_2800 ENOG4105C9Q fumarate hydratase class II L083_2801 ENOG4105PDP Short chain dehydrogenase L083_2802 ENOG4105C8Q Methyl-accepting chemotaxis L083_2808 ENOG4107YJ4 chain length determinant protein L083_2814 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) L083_2825 ENOG4107RSM transcriptional regulator L083_2826 ENOG4105CHR reductase L083_2829 ENOG4105CB2 alcohol dehydrogenase L083_2835 ENOG4105E1F short-chain dehydrogenase reductase L083_2839 ENOG4105C3M thioredoxin reductase L083_2841 ENOG4105WH1 Two component transcriptional regulator luxr family L083_2842 ENOG4105BZU Histidine kinase L083_2844 ENOG4108S01 response regulator L083_2847 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) L083_2854 ENOG4105ETX regulatoR L083_2855 ENOG4106F60 Histidine kinase L083_2856 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase L083_2857 ENOG4108W2P Methyl-accepting chemotaxis L083_2859 ENOG4105CEY Amp-dependent synthetase and ligase L083_2860 ENOG4105CG3 alpha amylase, catalytic region L083_2861 ENOG4105CPC Aldo Keto reductase L083_2862 ENOG41088YS Glycosyl transferase (Group 1 L083_2869 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) L083_2871 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) L083_2885 ENOG4107R13 MMPL domain protein L083_2888 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase L083_2889 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) L083_2892 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) L083_2893 ENOG4105D49 3-dehydroquinate synthase L083_2899 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase L083_2905 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) L083_2912 ENOG4105HMI Membrane L083_2918 ENOG4108KXV response regulator L083_2919 ENOG4105BZU Histidine kinase L083_2925 ENOG4105F27 Major Facilitator L083_2929 ENOG4105BZU Histidine kinase L083_2930 ENOG4105BZU Histidine kinase L083_2931 ENOG4105CPQ Dehydrogenase L083_2938 ENOG4107WA4 MmpL domain-containing protein L083_2947 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase L083_2949 ENOG4105BZU Histidine kinase L083_2951 ENOG4105EX0 alpha-galactosidase L083_2952 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) L083_2955 ENOG4108YRB methyltransferase L083_2970 ENOG4105CPF Cell wall formation (By similarity) L083_2973 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) L083_2974 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase L083_2975 ENOG4105EUJ GTP cyclohydrolase i L083_2977 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) L083_3002 ENOG4105CEY Amp-dependent synthetase and ligase L083_3003 ENOG4107EXU Short-chain dehydrogenase reductase Sdr L083_3005 ENOG4107RQ5 Methylates ribosomal protein L11 (By similarity) L083_3007 ENOG4105ETX regulatoR L083_3008 ENOG4105BZU Histidine kinase L083_3011 ENOG4105BZU Histidine kinase L083_3025 ENOG4106KE4 Dehydrogenase L083_3032 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP L083_3034 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_3035 ENOG41062D9 Histidine kinase L083_3039 ENOG4105C1G acyl-Coa dehydrogenase L083_3043 ENOG4105GWZ Roadblock lc7 family protein L083_3046 ENOG4105KME endoribonuclease L-psp L083_3053 ENOG4105WH1 Two component transcriptional regulator luxr family L083_3055 ENOG4105C1G acyl-Coa dehydrogenase L083_3058 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) L083_3062 ENOG4105JEU Glycosyl transferase, family 2 L083_3063 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) L083_3064 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) L083_3069 ENOG4108MYR Secreted protein L083_3073 ENOG4105EMU Dehydrogenase L083_3074 ENOG4105ERH Fumarylacetoacetate hydrolase L083_3077 ENOG4105C01 Dihydroxy-acid dehydratase L083_3078 ENOG4105CHR reductase L083_3085 ENOG4105E1F short-chain dehydrogenase reductase L083_3088 ENOG4107HP6 Transcriptional regulator L083_3089 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta L083_3092 ENOG4105C57 major facilitator superfamily L083_3100 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase L083_3101 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein L083_3102 ENOG4105D8K carboxyl transferase L083_3105 ENOG4107EXU Short-chain dehydrogenase reductase Sdr L083_3111 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr L083_3115 ENOG4106A3M Cytochrome p-450 L083_3121 ENOG4105CAQ asparagine synthetase L083_3123 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase L083_3128 ENOG4105CHR reductase L083_3130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase L083_3133 ENOG4105EQH reductase L083_3134 ENOG4105DUX Transporter L083_3138 ENOG4105WH1 Two component transcriptional regulator luxr family L083_3139 ENOG4105BZU Histidine kinase L083_3140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_3141 ENOG4107R34 abc transporter permease protein L083_3142 ENOG4107V9E glucose-1-phosphate thymidylyltransferase L083_3146 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) L083_3148 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) L083_3160 ENOG4105CHR reductase L083_3163 ENOG4108IV0 ABC, transporter L083_3164 ENOG4105CP9 extracellular ligand-binding receptor L083_3165 ENOG4105C0Z ABC transporter L083_3179 ENOG4105D8V Glucose sorbosone dehydrogenase L083_3181 ENOG4107S46 esterase, PHB depolymerase L083_3183 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component L083_3184 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component L083_3197 ENOG4105CIR epoxide hydrolase L083_3198 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) L083_3199 ENOG4105EXC Acyl-transferase L083_3213 ENOG41068W2 Cytochrome p-450 L083_3215 ENOG4105UEI Transcriptional Regulator AraC Family L083_3219 ENOG4105FQP Beta-lactamase L083_3222 ENOG4106YKD Cytochrome p-450 L083_3225 ENOG4105CAQ asparagine synthetase L083_3227 ENOG4105NAE bifunctional deaminase-reductase domain protein L083_3229 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone L083_3231 ENOG4105CHP RNA polymerase L083_3237 ENOG4108TVJ Nitroreductase L083_3243 ENOG4107QK4 glycoside hydrolase, family 3 domain protein L083_3246 ENOG4105KVH Transcriptional regulator L083_3247 ENOG4106F60 Histidine kinase L083_3249 ENOG4105F44 Two component transcriptional regulator, winged helix family L083_3253 ENOG4105DPZ Two component transcriptional regulator (Winged helix family L083_3256 ENOG4105ESP cell wall surface anchor family protein L083_3260 ENOG4105ECP epimerase L083_3261 ENOG4105DFW ABC transporter L083_3263 ENOG4108HWW ABC transporter L083_3265 ENOG4105EX0 alpha-galactosidase L083_3266 ENOG4107S46 esterase, PHB depolymerase L083_3278 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) L083_3281 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) L083_3285 ENOG4105I82 acetyl xylan esterase L083_3286 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) L083_3287 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr L083_3288 ENOG4108Z40 Transcriptional regulator L083_3289 ENOG4108ZJ4 polysaccharide deacetylase L083_3290 ENOG4108V06 Glutathione peroxidase L083_3292 ENOG4105CWX Alpha-1,2-mannosidase L083_3295 ENOG4105E2A Dehydrogenase L083_3297 ENOG4107SM8 Adenylate Guanylate cyclase L083_3299 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase L083_3302 ENOG4107SM8 Adenylate Guanylate cyclase L083_3308 ENOG4107R6F Alpha Beta Hydrolase Fold protein L083_3313 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) L083_3315 ENOG4107S21 permease L083_3318 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component L083_3319 ENOG4105C3U ABC transporter L083_3322 ENOG4108K8K Transcriptional regulator L083_3326 ENOG4105DTQ mandelate racemase muconate lactonizing L083_3336 ENOG4107QNK )-transporter L083_3337 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein L083_3339 ENOG4108W5M transcriptional regulator L083_3340 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit L083_3341 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding L083_3342 ENOG4105C7W Xanthine dehydrogenase L083_3353 ENOG4107S1E Beta-lactamase L083_3354 ENOG4106F60 Histidine kinase L083_3358 ENOG4108IND Tetr family transcriptional regulator L083_3365 ENOG4105ETX regulatoR L083_3366 ENOG4105DQ4 alcohol dehydrogenase L083_3367 ENOG4107UBC ErfK ybiS ycfS ynhG family protein L083_3370 ENOG4107T94 Endo-14-beta-xylanase L083_3380 ENOG4105C2J ABC transporter L083_3381 ENOG4105UIB (ABC) transporter L083_3384 ENOG4107SCK Monooxygenase L083_3388 ENOG4105DJ2 Major Facilitator Superfamily L083_3396 ENOG4105CMR udp-glucose 4-epimerase L083_3398 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_3399 ENOG4105EB3 Histidine kinase L083_3400 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) L083_3405 ENOG4107YXZ hydrolase, family 25 L083_3407 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) L083_3409 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) L083_3410 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) L083_3416 ENOG4105CIG ABC transporter L083_3417 ENOG4107YB1 Trehalose corynomycolyl transferase L083_3420 ENOG4105CJW magnesium transporter L083_3421 ENOG41068KF Universal stress protein L083_3437 ENOG4108EKI Dehydrogenase L083_3439 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase L083_3446 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) L083_3448 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha L083_3459 ENOG4105F1A Pyruvate formate-lyase L083_3462 ENOG4105C6N Formate acetyltransferase L083_3463 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) L083_3464 ENOG4105CJW magnesium transporter L083_3466 ENOG4107QRI Phosphoketolase L083_3475 ENOG4105CWX Alpha-1,2-mannosidase L083_3476 ENOG4105DBE peroxidase L083_3478 ENOG4105EKT )-iron permease L083_3480 ENOG4107T8T UPF0173 metal-dependent hydrolase L083_3483 ENOG4105CHR reductase L083_3484 ENOG4106R7G Glycoside hydrolase family 5 L083_3488 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) L083_3490 ENOG4105C57 major facilitator superfamily L083_3492 ENOG4105KVH Transcriptional regulator L083_3494 ENOG4105EMU Dehydrogenase L083_3495 ENOG4108SGK Tetr family transcriptional regulator L083_3496 ENOG4107S5I aldo keto reductase L083_3509 ENOG4105C7K acetolactate synthase L083_3510 ENOG4107R33 ppx gppa phosphatase L083_3519 ENOG4105ETE Transcriptional regulator (LacI family L083_3524 ENOG4105G6Z alkaline phosphatase L083_3539 ENOG4105DBE peroxidase L083_3541 ENOG41072TH Protein of unknown function (DUF1479) L083_3542 ENOG4105DSE periplasmic solute binding protein L083_3543 ENOG4105DIK (ABC) transporter L083_3544 ENOG4107RBD ABC, transporter L083_3547 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) L083_3549 ENOG4105D9G High-affinity L083_3554 ENOG41069ER domain protein L083_3556 ENOG4105C57 major facilitator superfamily L083_3558 ENOG4105C57 major facilitator superfamily L083_3559 ENOG4105D8V Glucose sorbosone dehydrogenase L083_3561 ENOG4105C5I Dehydrogenase L083_3563 ENOG4105CD8 aminopeptidase N L083_3568 ENOG4108J4B Beta-lactamase L083_3569 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins L083_3575 ENOG4105CUB amino acid L083_3579 ENOG4107QZ7 Cellulose synthase catalytic subunit L083_3581 ENOG4105F0N pyrophosphate phospho-hydrolase L083_3582 ENOG4105E39 Enoyl-CoA hydratase L083_3591 ENOG4105BZU Histidine kinase L083_3593 ENOG4108K8S endonuclease I L083_3594 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) L083_3595 ENOG4108UQS dipeptidase L083_3598 ENOG4105CBG Sulfatase L083_3599 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) L083_3602 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein L083_3609 ENOG4105BZN citrate synthase L083_3615 ENOG4107SFI Major Facilitator superfamily L083_3616 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component L083_3617 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component L083_3624 ENOG4105C84 Histidine ammonia-lyase L083_3627 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase L083_3629 ENOG4105EMU Dehydrogenase L083_3630 ENOG4105WH1 Two component transcriptional regulator luxr family L083_3631 ENOG4108YV4 Universal stress protein L083_3639 ENOG4105CJA serine threonine protein kinase L083_3643 ENOG4108S01 response regulator L083_3644 ENOG4105CJQ hydrolase, family 31 L083_3653 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) L083_3655 ENOG4108MMM RNA Polymerase L083_3656 ENOG4105CWX Alpha-1,2-mannosidase L083_3661 ENOG4105F0K SARP family transcriptional regulator L083_3664 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) L083_3665 ENOG4105CPQ Dehydrogenase L083_3673 ENOG4105CJ1 ABC, transporter L083_3678 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) L083_3682 ENOG4105C7H Helicase, RecD TraA family L083_3685 ENOG4105BZU Histidine kinase L083_3700 ENOG4105EA8 2-Nitropropane dioxygenase L083_3701 ENOG4107W53 thymidine kinase L083_3709 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) L083_3710 ENOG4108RZE Tetr family transcriptional regulator L083_3720 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 L083_3723 ENOG41082BM Transcriptional regulator, arsr family L083_3725 ENOG4108J20 pectate lyase L083_3729 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein L083_3735 ENOG4105DDW LysR family Transcriptional regulator L083_3736 ENOG4105C57 major facilitator superfamily L083_3739 ENOG4105CHR reductase L083_3748 ENOG4105ETE Transcriptional regulator (LacI family L083_3752 ENOG4108I5D sulfate abc transporter L083_3753 ENOG4105CXK mandelate racemase muconate lactonizing L083_3761 ENOG4105ESF Peptidoglycan binding domain protein L083_3768 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) L083_3772 ENOG4105ETE Transcriptional regulator (LacI family L083_3773 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator L083_3774 ENOG4105C2J ABC transporter L083_3775 ENOG4107R9N ABC transporter L083_3776 ENOG41062B0 ABC transporter, permease L083_3784 ENOG4105D9R oxidoreductase L083_3785 ENOG4105DIA mandelate racemase muconate lactonizing L083_3786 ENOG4105DEI Mannitol dehydrogenase L083_3787 ENOG4105D2H Uronic isomerase L083_3788 ENOG4105DDC Oxidoreductase domain protein L083_3789 ENOG41060NJ transcriptional regulator L083_3791 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component L083_3792 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component L083_3803 ENOG4108PVQ transcriptional regulator L083_3805 ENOG4105JSC dimethylmenaquinone methyltransferase L083_3808 ENOG4105KHM amidohydrolase 2 L083_3820 ENOG4108V1T peptidylprolyl cis-trans isomerase L083_3821 ENOG4107XFJ UPF0246 protein L083_3825 ENOG4105BZU Histidine kinase L083_3829 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) L083_3831 ENOG4105MXW flavin reductase domain protein, FMN-binding L083_3832 ENOG4108UZX fmn reductase L083_3839 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component L083_3848 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) L083_3849 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) L083_3850 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein L083_3852 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) L083_3854 ENOG4105CIR epoxide hydrolase L083_3856 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) L083_3863 ENOG4105MC2 DSBA oxidoreductase L083_3867 ENOG4106NMR serine protease L083_3873 ENOG4107QNK )-transporter L083_3878 ENOG4105WH1 Two component transcriptional regulator luxr family L083_3879 ENOG4105BZU Histidine kinase L083_3885 ENOG4108PJD permease L083_3887 ENOG4107T8P acyl-Coa dehydrogenase L083_3889 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) L083_3892 ENOG4105ETE Transcriptional regulator (LacI family L083_3895 ENOG4105BZU Histidine kinase L083_3909 ENOG4105ETX regulatoR L083_3913 ENOG4105HFS 5'-3' exonuclease L083_3914 ENOG4105C1G acyl-Coa dehydrogenase L083_3915 ENOG4105J0Q Transcriptional regulator L083_3919 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase L083_3924 ENOG4105FRY Dehydrogenase L083_3925 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein L083_3926 ENOG4105EFZ amidohydrolase L083_3927 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit L083_3928 ENOG4107CHF 5,6-aminomutase beta subunit L083_3929 ENOG4108UYI beta-alanyl-CoA ammonia lyase L083_3932 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) L083_3937 ENOG4105Q70 L083_3943 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin L083_3944 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid L083_3949 ENOG4108SGK Tetr family transcriptional regulator L083_3957 ENOG4107S5I aldo keto reductase L083_3959 ENOG41090KN UPF0303 protein L083_3961 ENOG4105K56 Transcriptional regulator L083_3962 ENOG4108ZHJ Organic hydroperoxide resistance protein L083_3969 ENOG4105CPQ Dehydrogenase L083_3978 ENOG4105WH1 Two component transcriptional regulator luxr family L083_3985 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) L083_3986 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) L083_3988 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) L083_3989 ENOG4108S01 response regulator L083_3990 ENOG4105BZU Histidine kinase L083_3992 ENOG4108M15 ABC transporter L083_3996 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) L083_3998 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) L083_4002 ENOG4108R85 Short chain dehydrogenase L083_4003 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor L083_4005 ENOG4105CPC Aldo Keto reductase L083_4008 ENOG4108FN7 Aldo keto reductase L083_4013 ENOG4105EBR Carboxylesterase L083_4025 ENOG4108UW8 fha domain-containing protein L083_4032 ENOG4107KWJ von Willebrand factor, type A L083_4033 ENOG4105EET magnesium chelatase L083_4034 ENOG4105JAB phenazine biosynthesis protein, phzf family L083_4036 ENOG4105F32 YngK protein L083_4038 ENOG4107QPH glycogen) synthase L083_4039 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) L083_4045 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) L083_4063 ENOG4108KQ5 Integrase catalytic subunit L083_4066 ENOG4105BZU Histidine kinase L083_4067 ENOG4105WH1 Two component transcriptional regulator luxr family L083_4069 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) L083_4075 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) L083_4078 ENOG4108JQ6 ABC transporter L083_4079 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component L083_4081 ENOG4105DEF Extracellular solute-binding protein, family 5 L083_4085 ENOG4105F76 Sarcosine oxidase L083_4086 ENOG4105DVW rieske (2Fe-2S) L083_4089 ENOG4108HQS Glycine betaine L083_4090 ENOG4108IJ7 Glycine betaine L083_4105 ENOG4105CJQ hydrolase, family 31 L083_4109 ENOG4105ETE Transcriptional regulator (LacI family L083_4112 ENOG4108UGD Serine Threonine protein kinase L083_4134 ENOG4107QKS N-acylglucosamine 2-epimerase L083_4138 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) L083_4141 ENOG4105DQQ Major facilitator superfamily MFS_1 L083_4142 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit L083_4143 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) L083_4144 ENOG4108IFG nitrite reductase, (NAD(P)H) L083_4147 ENOG4106R7G Glycoside hydrolase family 5 L083_4150 ENOG41087EV Hsp20/alpha crystallin family L083_4151 ENOG4105BZU Histidine kinase L083_4154 ENOG4105CEY Amp-dependent synthetase and ligase L083_4157 ENOG4105FQ6 thiopurine methyltransferase L083_4160 ENOG41060NJ transcriptional regulator L083_4168 ENOG4105M4P Tetr family transcriptional regulator L083_4171 ENOG4108NVR Methyl-accepting chemotaxis L083_4172 ENOG4105CPC Aldo Keto reductase L083_4174 ENOG4105D38 putrescine abc transporter L083_4175 ENOG4108IJ9 (ABC) transporter L083_4177 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) L083_4188 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) L083_4189 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) L083_4191 ENOG4105F38 ABC transporter, permease L083_4192 ENOG4105D38 putrescine abc transporter L083_4193 ENOG4105CJP fad dependent oxidoreductase L083_4195 ENOG4105DEN Luciferase family L083_4198 ENOG4105CJP fad dependent oxidoreductase L083_4199 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) L083_4200 ENOG4105EW9 transcriptional regulator AsnC family L083_4206 ENOG4105CJ1 ABC, transporter L083_4211 ENOG4105C26 Dehydrogenase L083_4213 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone L083_4214 ENOG4105C2M dna polymerase I L083_4219 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E L083_4224 ENOG4105CJ1 ABC, transporter L083_4228 ENOG4105F8J Adenylate Guanylate cyclase L083_4235 ENOG4108M8W Monooxygenase L083_4238 ENOG4105D9G High-affinity L083_4242 ENOG4106TD9 Diguanylate cyclase L083_4245 ENOG4105BZU Histidine kinase L083_4250 ENOG4105CX8 fg-gap repeat protein L083_4252 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family L083_4254 ENOG4107XBN GntR Family Transcriptional Regulator L083_4256 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component L083_4257 ENOG4105E2Y ABC, transporter L083_4263 ENOG4105VEQ Cold shock protein L083_4270 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) L083_4272 ENOG4108UYE Lactoylglutathione lyase L083_4273 ENOG4105EGE secreted protein L083_4276 ENOG4105S6R Iron-hydroxamate transporter permease subunit L083_4277 ENOG4105J76 Periplasmic binding protein L083_4278 ENOG4105E0A ABC, transporter L083_4282 ENOG4107S5I aldo keto reductase L083_4283 ENOG4107VFM Dehydrogenase L083_4289 ENOG4105EG6 Saccharopine dehydrogenase L083_4291 ENOG4105KZX Pterin carbinolamine dehydratase L083_4295 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase L083_4296 ENOG4105F2Z 3-oxoadipate enol-lactonase L083_4297 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase L083_4308 ENOG4105EYF MMPL domain protein L083_4311 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) L083_4316 ENOG4105NGS secreted protein L083_4317 ENOG4105VS8 Flagellar biosynthetic protein fliq L083_4318 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) L083_4320 ENOG4105DFW ABC transporter L083_4324 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase L083_4325 ENOG4105CG5 Glycosyl transferase (Group 1 L083_4326 ENOG4105BZ4 penicillin-binding protein L083_4330 ENOG4105BZU Histidine kinase L083_4339 ENOG4105BZU Histidine kinase L083_4342 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase L083_4349 ENOG4105CYP glycoside hydrolase, family L083_4354 ENOG4105C4C beta-galactosidase L083_4356 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component L083_4358 ENOG4105ETE Transcriptional regulator (LacI family L083_4359 ENOG4105MS9 Resuscitation-promoting factor L083_4361 ENOG4105DTQ mandelate racemase muconate lactonizing L083_4368 ENOG4107ZXU DSBA oxidoreductase L083_4372 ENOG4105CVM Molybdenum cofactor synthesis domain protein L083_4373 ENOG4105MSY salicylate hydroxylase L083_4378 ENOG4105C7W Xanthine dehydrogenase L083_4380 ENOG4105C3R Methionine synthase L083_4381 ENOG4107ZUX Histidine triad (HIT) protein L083_4382 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein L083_4387 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) L083_4389 ENOG4105S8Q sugar efflux transporter L083_4392 ENOG4107YBY Hydrolase L083_4394 ENOG4108W5M transcriptional regulator L083_4397 ENOG4105EM7 Selenocysteine-specific translation elongation factor L083_4398 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) L083_4401 ENOG4105CNV Aldolase L083_4402 ENOG4105DMF Dehydrogenase L083_4403 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) L083_4404 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) L083_4408 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) L083_4413 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) L083_4416 ENOG4105C9U ATP-dependent DNA helicase RecQ L083_4421 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) L083_4425 ENOG410630P Transcriptional regulator L083_4426 ENOG4105EE1 crotonyl-CoA reductase L083_4427 ENOG4105D58 Diguanylate phosphodiesterase L083_4428 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase L083_4435 ENOG4105CQB FAD linked oxidase domain protein L083_4436 ENOG4105CQB FAD linked oxidase domain protein L083_4437 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) L083_4443 ENOG4105DYC esterase L083_4445 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) L083_4449 ENOG4107SCK Monooxygenase L083_4452 ENOG4105BZU Histidine kinase L083_4454 ENOG4107FW0 short-chain dehydrogenase reductase L083_4456 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) L083_4458 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) L083_4459 ENOG4108JJB ABC transporter L083_4462 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) L083_4463 ENOG4105ETE Transcriptional regulator (LacI family L083_4465 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) L083_4470 ENOG41080E2 ribosomal-protein-alanine acetyltransferase L083_4480 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) L083_4481 ENOG4105BZU Histidine kinase L083_4488 ENOG4108UTZ Dihydroxyacetone kinase L083_4489 ENOG4105CMT Dihydroxyacetone kinase L083_4492 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_4493 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) L083_4502 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) L083_4506 ENOG4105BZU Histidine kinase L083_4507 ENOG4105BZU Histidine kinase L083_4508 ENOG4105DUX Transporter L083_4511 ENOG4105DK7 lysyl-tRNA synthetase L083_4513 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) L083_4514 ENOG4105BZU Histidine kinase L083_4520 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) L083_4525 ENOG4108Z6Z Transcriptional regulator L083_4528 ENOG4108JGH Tetr family transcriptional regulator L083_4529 ENOG4105C57 major facilitator superfamily L083_4531 ENOG4106VEM tagatose-6-phosphate kinase L083_4532 ENOG4105D7K pfkb domain protein L083_4538 ENOG4105E98 transcriptional regulator DeoR family L083_4540 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) L083_4541 ENOG4107FKK extracellular solute-binding protein family 1 L083_4543 ENOG4105DRS transport system, permease L083_4547 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) L083_4551 ENOG4105E8R UPF0173 metal-dependent hydrolase L083_4565 ENOG4105ETX regulatoR L083_4567 ENOG4105EMU Dehydrogenase L083_4572 ENOG4105CHR reductase L083_4575 ENOG4105FDP GntR family transcriptional regulator L083_4576 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) L083_4577 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) L083_4581 ENOG4105BZU Histidine kinase L083_4582 ENOG4105ZXU NLP P60 protein L083_4583 ENOG4105D0M Protease HtpX homolog L083_4584 ENOG4105C4M (Ubiquinol oxidase) subunit I L083_4586 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii L083_4587 ENOG4108JJ9 ABC, transporter L083_4589 ENOG4105BZU Histidine kinase L083_4591 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase L083_4592 ENOG4105DKP glycosyl transferase, family 9 L083_4593 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) L083_4594 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) L083_4595 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) L083_4597 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase L083_4603 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone L083_4607 ENOG4105CPC Aldo Keto reductase L083_4610 ENOG4108W9H Tetr family transcriptional regulator L083_4612 ENOG4105BZ1 (ABC) transporter L083_4613 ENOG4105BZ1 (ABC) transporter L083_4614 ENOG41086D8 Transcriptional regulator L083_4617 ENOG4107R72 Ceramidase L083_4618 ENOG4105ETE Transcriptional regulator (LacI family L083_4620 ENOG4105EGI Transcriptional regulator L083_4622 ENOG4105CFH Aspartokinase L083_4623 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) L083_4625 ENOG4107QXX ABC transporter L083_4626 ENOG4105DJI Methylaspartate mutase, E subunit L083_4627 ENOG4105ETX regulatoR L083_4628 ENOG41062D9 Histidine kinase L083_4629 ENOG4105EYF MMPL domain protein L083_4635 ENOG4105ETE Transcriptional regulator (LacI family L083_4637 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component L083_4650 ENOG4107QJT sodium dicarboxylate symporter L083_4651 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism L083_4652 ENOG4108MRH transcriptional regulatory protein L083_4654 ENOG4107QK4 glycoside hydrolase, family 3 domain protein L083_4655 ENOG4105BZ4 penicillin-binding protein L083_4657 ENOG4105C6Z Gluconate L083_4658 ENOG4105CHR reductase L083_4659 ENOG41067SE Tetr family transcriptional regulator L083_4662 ENOG4108JJ8 (ABC) transporter L083_4663 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii L083_4664 ENOG4108JJ9 ABC, transporter L083_4665 ENOG4105C4M (Ubiquinol oxidase) subunit I L083_4666 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_4667 ENOG4105BZU Histidine kinase L083_4669 ENOG4105EPJ extracellular solute-binding protein family 1 L083_4670 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component L083_4671 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component L083_4672 ENOG4105EEM helicase L083_4680 ENOG4105BZU Histidine kinase L083_4681 ENOG4105BZU Histidine kinase L083_4684 ENOG4105ETE Transcriptional regulator (LacI family L083_4685 ENOG4108J59 Extracellular solute-binding protein, family 5 L083_4686 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component L083_4688 ENOG4108JQ6 ABC transporter L083_4694 ENOG4105E2B Taurine dioxygenase L083_4695 ENOG4108IY8 ABC, transporter L083_4696 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein L083_4697 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component L083_4698 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) L083_4699 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) L083_4704 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) L083_4713 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) L083_4715 ENOG4105CUB amino acid L083_4717 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone L083_4719 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_4723 ENOG4105CPC Aldo Keto reductase L083_4725 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) L083_4730 ENOG4105DU0 nucleoside hydrolase L083_4735 ENOG4108YV4 Universal stress protein L083_4740 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) L083_4741 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit L083_4742 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit L083_4743 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit L083_4744 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit L083_4747 ENOG4108IG5 Transcriptional regulator L083_4753 ENOG4105CJ1 ABC, transporter L083_4756 ENOG4105WH1 Two component transcriptional regulator luxr family L083_4758 ENOG4105C2J ABC transporter L083_4759 ENOG41062B0 ABC transporter, permease L083_4761 ENOG4105C26 Dehydrogenase L083_4763 ENOG4105DH8 myo-inositol catabolism L083_4764 ENOG4105EDK PfkB domain protein L083_4766 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b L083_4777 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_4778 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_4779 ENOG4105DJY efflux transporter, rnd family, mfp subunit L083_4780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_4781 ENOG4105BZU Histidine kinase L083_4785 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) L083_4786 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) L083_4787 ENOG4105DAA L-lactate L083_4788 ENOG4106UDK Cellulose-binding, family II L083_4792 ENOG4105F27 Major Facilitator L083_4794 ENOG4107TB6 phosphoglycerate mutase L083_4795 ENOG4108UZX fmn reductase L083_4812 ENOG4107QP8 phosphohexose isomerase L083_4815 ENOG4105CPQ Dehydrogenase L083_4826 ENOG4105WH1 Two component transcriptional regulator luxr family L083_4840 ENOG4105CMR udp-glucose 4-epimerase L083_4845 ENOG410901E Membrane L083_4846 ENOG4105WCN acetyltransferase L083_4847 ENOG4107XWB Zinc finger, swim domain protein L083_4848 ENOG4105C0D helicase L083_4851 ENOG4105CPF Cell wall formation (By similarity) L083_4855 ENOG4105CUB amino acid L083_4857 ENOG4107TPY serine threonine protein kinase L083_4873 ENOG4105WQG acetyltransferase L083_4876 ENOG4108K2F hydrolase Family 5 L083_4882 ENOG4107RN3 metallophosphoesterase L083_4893 ENOG4105ETE Transcriptional regulator (LacI family L083_4904 ENOG4105C0H protease L083_4909 ENOG4105E2D ec 3.2.1.52 L083_4916 ENOG410848D S4 domain protein YaaA L083_4922 ENOG4105WN5 stage II sporulation protein L083_4927 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) L083_4933 ENOG4105DKQ ROK family L083_4935 ENOG4108HWW ABC transporter L083_4936 ENOG4105C2J ABC transporter L083_4937 ENOG4105DFW ABC transporter L083_4938 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) L083_4940 ENOG4105ETE Transcriptional regulator (LacI family L083_4943 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) L083_4947 ENOG4105EUB pirin domain protein L083_4953 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_4959 ENOG4105BZU Histidine kinase L083_4961 ENOG4105C8Q Methyl-accepting chemotaxis L083_4962 ENOG4105CBS Chea signal transduction histidine kinase L083_4963 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) L083_4964 ENOG4105BZU Histidine kinase L083_4965 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_4966 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_4967 ENOG4105ENE Histidine kinase L083_4968 ENOG4105WH1 Two component transcriptional regulator luxr family L083_4974 ENOG4106WTF Glycosyl transferase, family 2 L083_4978 ENOG4105DEI Mannitol dehydrogenase L083_4979 ENOG4107R9S Malate synthase L083_4984 ENOG4105CFG Acts as a chaperone (By similarity) L083_4990 ENOG4105CSU acyl-Coa dehydrogenase L083_5003 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) L083_5005 ENOG4105DQ4 alcohol dehydrogenase L083_5006 ENOG4105BZU Histidine kinase L083_5007 ENOG4105BZU Histidine kinase L083_5013 ENOG4105WH1 Two component transcriptional regulator luxr family L083_5014 ENOG4108ZGX Histidine kinase L083_5015 ENOG4105EYF MMPL domain protein L083_5016 ENOG4105NBR Pectinesterase L083_5025 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) L083_5026 ENOG4108ZMQ domain protein L083_5034 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_5035 ENOG4107R34 abc transporter permease protein L083_5036 ENOG4105CEY Amp-dependent synthetase and ligase L083_5039 ENOG4105CT1 (ABC) transporter L083_5041 ENOG4107Q25 Serine Threonine protein kinase L083_5042 ENOG4108ZF3 Phosphatase L083_5046 ENOG4107TK4 histidinol-phosphate phosphatase L083_5048 ENOG4108Z12 YiaAB two helix domain-containing protein L083_5049 ENOG4105CQR helicase L083_5050 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) L083_5055 ENOG4105DKW ABC transporter L083_5056 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) L083_5057 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) L083_5060 ENOG4107TMB Transcriptional regulator L083_5066 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) L083_5069 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) L083_5070 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) L083_5071 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) L083_5072 ENOG4105E5F proteasome L083_5073 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) L083_5085 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_5086 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_5087 ENOG4107VXZ Hydrolase L083_5088 ENOG4105CPC Aldo Keto reductase L083_5090 ENOG4105CHP RNA polymerase L083_5092 ENOG4105GRZ Ycii-related protein L083_5093 ENOG4108UGV hypoxanthine phosphoribosyltransferase L083_5094 ENOG4108T9J Cdp-alcohol phosphatidyltransferase L083_5113 ENOG4105C8N cysteinyl-tRNA synthetase L083_5117 ENOG4105DYW oxidoreductase L083_5118 ENOG4105CPC Aldo Keto reductase L083_5126 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) L083_5128 ENOG4108KXM LysR family Transcriptional regulator L083_5129 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit L083_5133 ENOG4105EC2 ftsk spoIIIe L083_5143 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_5145 ENOG4105JXB ankyrin repeat-containing protein L083_5147 ENOG4105ECQ AraC Family Transcriptional Regulator L083_5149 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving L083_5152 ENOG4105EP9 oxidoreductase L083_5153 ENOG4105C3Q Glycosyl transferase, family 2 L083_5156 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) L083_5157 ENOG4105BZU Histidine kinase L083_5159 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) L083_5177 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) L083_5179 ENOG4105CMG Carbohydrate kinase L083_5185 ENOG4105CGK Exodeoxyribonuclease III L083_5191 ENOG4105BZU Histidine kinase L083_5192 ENOG4105CQ7 ATP-dependent helicase L083_5195 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj L083_5202 ENOG410905P Pyridoxamine 5-phosphate L083_5208 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) L083_5212 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) L083_5224 ENOG4105WH1 Two component transcriptional regulator luxr family L083_5225 ENOG4105BZM domain protein L083_5229 ENOG4105EYF MMPL domain protein L083_5231 ENOG4105WH1 Two component transcriptional regulator luxr family L083_5235 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) L083_5251 ENOG4105C6Y Udp-glucose 6-dehydrogenase L083_5258 ENOG4105IJJ transcriptional regulator, crp fnr family L083_5260 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold L083_5262 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase L083_5269 ENOG4105C38 Glycyl-tRNA synthetase beta subunit L083_5270 ENOG4105C1G acyl-Coa dehydrogenase L083_5273 ENOG4105C6V Glycerol-3-phosphate dehydrogenase L083_5274 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) L083_5275 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) L083_5276 ENOG4108K8U Glycerol operon regulatory protein L083_5277 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) L083_5288 ENOG41063PX domain protein L083_5293 ENOG4105C1B dTDP-glucose 4-6-dehydratase L083_5294 ENOG4105C6Y Udp-glucose 6-dehydrogenase L083_5299 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) L083_5305 ENOG4105C8Y Acetylornithine aminotransferase L083_5306 ENOG4105CSW GntR family transcriptional regulator L083_5309 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) L083_5311 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component L083_5313 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component L083_5321 ENOG4105DFW ABC transporter L083_5322 ENOG4105CNN ABC, transporter L083_5324 ENOG4105EYF MMPL domain protein L083_5327 ENOG4105BZ1 (ABC) transporter L083_5336 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) L083_5337 ENOG4105CG3 alpha amylase, catalytic region L083_5339 ENOG4105QE3 oxidoreductase L083_5341 ENOG4105CHU acetyl-coa acetyltransferase L083_5344 ENOG4107QNJ CoA-transferase subunit B L083_5346 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_5353 ENOG4105ETE Transcriptional regulator (LacI family L083_5356 ENOG4107TXC Transcriptional regulator L083_5363 ENOG4105CPC Aldo Keto reductase L083_5367 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) L083_5370 ENOG4105EJ9 Membrane L083_5374 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase L083_5375 ENOG4105DZS Phenylacetate-CoA ligase L083_5377 ENOG41061GT Aldolase L083_5378 ENOG4106M32 3-dehydroquinate synthase L083_5382 ENOG4107SCK Monooxygenase L083_5386 ENOG4105M6F mutator MutT protein L083_5387 ENOG41065HY 1,4-beta-cellobiosidase L083_5391 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) L083_5407 ENOG4105CUB amino acid L083_5421 ENOG4105DFW ABC transporter L083_5428 ENOG4105C1G acyl-Coa dehydrogenase L083_5440 ENOG4105E50 uracil-dna glycosylase L083_5446 ENOG4108XFH Transcriptional regulator L083_5458 ENOG4105T1M mycothiol conjugate amidase mca L083_5459 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_5462 ENOG4105CJ1 ABC, transporter L083_5467 ENOG4105FBN Acid phosphatase L083_5472 ENOG41082SX arsR family transcriptional regulator L083_5473 ENOG4105CQB FAD linked oxidase domain protein L083_5474 ENOG4107XBN GntR Family Transcriptional Regulator L083_5476 ENOG4105BZ4 penicillin-binding protein L083_5484 ENOG4107TPY serine threonine protein kinase L083_5488 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) L083_5495 ENOG4107Y80 Major Facilitator superfamily L083_5496 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) L083_5498 ENOG4105C6Y Udp-glucose 6-dehydrogenase L083_5508 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone L083_5511 ENOG4108DBC nitroreductase L083_5516 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component L083_5519 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase L083_5520 ENOG4105YVS arsR family transcriptional regulator L083_5521 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) L083_5522 ENOG4105CPU Monooxygenase L083_5524 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component L083_5535 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) L083_5544 ENOG4105GFR rna polymerase sigma factor L083_5548 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) L083_5561 ENOG4105CQF Transcriptional regulator L083_5563 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) L083_5564 ENOG4105CHM Aminotransferase L083_5565 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) L083_5566 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) L083_5567 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) L083_5568 ENOG41080HT Transcriptional regulator, arsr family L083_5570 ENOG4105CEY Amp-dependent synthetase and ligase L083_5576 ENOG4105D06 uba thif-type nad fad binding protein L083_5579 ENOG4105ETE Transcriptional regulator (LacI family L083_5582 ENOG4105DRS transport system, permease L083_5586 ENOG4107RK0 Sucrose phosphorylase L083_5588 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component L083_5589 ENOG4108JP0 extracellular solute-binding protein family 1 L083_5591 ENOG4105ETE Transcriptional regulator (LacI family L083_5596 ENOG4108PC0 lipolytic protein G-D-S-L family L083_5597 ENOG4105EE1 crotonyl-CoA reductase L083_5599 ENOG4105BZU Histidine kinase L083_5606 ENOG4107SYN Glycosyl hydrolases family 43 L083_5612 ENOG4105D9P serine threonine protein kinase L083_5618 ENOG4107RQ0 Maleylacetate reductase L083_5619 ENOG4105K6H D-cysteine desulfhydrase L083_5622 ENOG410600Z Regulatory protein MarR L083_5623 ENOG4105CIG ABC transporter L083_5626 ENOG4108E16 pectate lyase L083_5627 ENOG4108J20 pectate lyase L083_5632 ENOG4105K6V RNA polymerase L083_5634 ENOG410834F Transcriptional regulator L083_5635 ENOG4105EYF MMPL domain protein L083_5643 ENOG4105CEY Amp-dependent synthetase and ligase L083_5646 ENOG4108JJA ABC, transporter L083_5647 ENOG4106A3M Cytochrome p-450 L083_5648 ENOG4105C5S asparaginyl-tRNA synthetase L083_5650 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) L083_5652 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A L083_5654 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) L083_5660 ENOG4107SM8 Adenylate Guanylate cyclase L083_5664 ENOG4106R7G Glycoside hydrolase family 5 L083_5665 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) L083_5667 ENOG4105C2J ABC transporter L083_5668 ENOG4105CNN ABC, transporter L083_5669 ENOG4105DIA mandelate racemase muconate lactonizing L083_5670 ENOG41073TP transcriptional regulator L083_5671 ENOG4107EJG GntR family transcriptional regulator L083_5675 ENOG4105DIA mandelate racemase muconate lactonizing L083_5676 ENOG4105DRS transport system, permease L083_5679 ENOG4105CPQ Dehydrogenase L083_5680 ENOG4105CHR reductase L083_5681 ENOG4108UHU Aldolase L083_5693 ENOG4105H3G oxidoreductase L083_5695 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) L083_5696 ENOG4105E2X shikimate dehydrogenase L083_5697 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) L083_5702 ENOG4107XGZ Hydrolase L083_5705 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase L083_5706 ENOG4105D49 3-dehydroquinate synthase L083_5709 ENOG4105C1G acyl-Coa dehydrogenase L083_5710 ENOG4105D8K carboxyl transferase L083_5714 ENOG4105CPQ Dehydrogenase L083_5719 ENOG4108VQJ O-methyltransferase L083_5724 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) L083_5725 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase L083_5730 ENOG41062D9 Histidine kinase L083_5731 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family L083_5734 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_5735 ENOG4105BZU Histidine kinase L083_5736 ENOG4105EXC Acyl-transferase L083_5745 ENOG4108HMN Caspase domain L083_5746 ENOG4108V5V Serine Threonine protein kinase L083_5762 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) L083_5763 ENOG4105CAT Cytidine monophosphate kinase L083_5765 ENOG4105FE9 pseudouridine synthase L083_5766 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) L083_5782 ENOG4105EMU Dehydrogenase L083_5788 ENOG4105EMU Dehydrogenase L083_5789 ENOG4106NZI LysR family Transcriptional regulator L083_5791 ENOG4105CYP glycoside hydrolase, family L083_5808 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) L083_5811 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) L083_5817 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) L083_5822 ENOG4105DSU hydrolase L083_5826 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) L083_5827 ENOG4105CSR polyphosphate kinase 2 L083_5830 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) L083_5839 ENOG4108VX5 3-methyladenine DNA glycosylase L083_5844 ENOG4107SCK Monooxygenase L083_5847 ENOG4105KVH Transcriptional regulator L083_5853 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) L083_5854 ENOG4105CVJ phosphoglycerate mutase L083_5855 ENOG4105BZU Histidine kinase L083_5858 ENOG4105DRS transport system, permease L083_5860 ENOG4106NZI LysR family Transcriptional regulator L083_5861 ENOG4107TSN permease L083_5865 ENOG4105CH7 arginosuccinase L083_5866 ENOG4107R4C succinyl-diaminopimelate desuccinylase L083_5867 ENOG4105CDH Citrulline--aspartate ligase L083_5869 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) L083_5870 ENOG4105DBV ornithine carbamoyltransferase L083_5871 ENOG4105C8Y Acetylornithine aminotransferase L083_5872 ENOG4105CAS nag kinase L083_5873 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) L083_5874 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase L083_5876 ENOG4107QK4 glycoside hydrolase, family 3 domain protein L083_5878 ENOG4107GZ4 SanA protein L083_5883 ENOG4105CYP glycoside hydrolase, family L083_5893 ENOG4105CHR reductase L083_5894 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) L083_5895 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) L083_5896 ENOG4108RWN rrna methyltransferase L083_5897 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) L083_5898 ENOG41084BS 50S ribosomal protein L35 L083_5899 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) L083_5901 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) L083_5902 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase L083_5904 ENOG4105EAB amino acid AbC transporter L083_5905 ENOG4105EAD ABC transporter L083_5907 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) L083_5908 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) L083_5911 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_5915 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) L083_5916 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) L083_5919 ENOG4107RSZ Primosomal protein n' L083_5920 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP L083_5922 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) L083_5923 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) L083_5924 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits L083_5925 ENOG4105SKN orotidine 5''-phosphate decarboxylase L083_5927 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) L083_5929 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain L083_5930 ENOG4105CD3 dihydroorotase L083_5931 ENOG4105CXT aspartate transcarbamylase L083_5932 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) L083_5934 ENOG410803B Involved in the transcription termination process (By similarity) L083_5935 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) L083_5936 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) L083_5937 ENOG4105D49 3-dehydroquinate synthase L083_5938 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit L083_5939 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) L083_5940 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase L083_5943 ENOG4105E2X shikimate dehydrogenase L083_5945 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) L083_5946 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) L083_5959 ENOG4105C9M aspartyl-trna synthetase L083_5962 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_5996 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) L083_6032 ENOG4105JVQ RNA Polymerase L083_6035 ENOG41069H0 dihydroorotase EC 3.5.2.3 L083_6036 ENOG4105KME endoribonuclease L-psp L083_6037 ENOG4108KQ5 Integrase catalytic subunit L083_6039 ENOG4108YZ9 Urea amidohydrolase subunit gamma L083_6040 ENOG4105KI2 Urea amidohydrolase subunit beta L083_6041 ENOG4105CQM Urea amidohydrolase subunit alpha L083_6043 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) L083_6044 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) L083_6045 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) L083_6048 ENOG4107TPY serine threonine protein kinase L083_6049 ENOG4107RRY Cyanophycin synthetase L083_6051 ENOG4107SFI Major Facilitator superfamily L083_6055 ENOG4105CUT histidyl-tRNA synthetase L083_6058 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) L083_6061 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) L083_6062 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) L083_6066 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) L083_6067 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) L083_6068 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) L083_6070 ENOG4105CDY transcriptional regulatory protein L083_6071 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) L083_6072 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) L083_6074 ENOG4105E2K Glycosyl transferase (Group 1 L083_6075 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase L083_6079 ENOG4105JVQ RNA Polymerase L083_6084 ENOG410804D Sensor Signal Transduction Histidine Kinase L083_6087 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) L083_6088 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) L083_6089 ENOG4108FN7 Aldo keto reductase L083_6091 ENOG4105VEQ Cold shock protein L083_6099 ENOG4105D17 glycoside hydrolase, family 3 domain protein L083_6102 ENOG4105C9U ATP-dependent DNA helicase RecQ L083_6103 ENOG4105UYK outer membrane protein a L083_6107 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase L083_6109 ENOG4105BZU Histidine kinase L083_6114 ENOG4105H9W Short-chain dehydrogenase reductase Sdr L083_6125 ENOG4107VXZ Hydrolase L083_6131 ENOG4105EUB pirin domain protein L083_6138 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 L083_6142 ENOG4105WH1 Two component transcriptional regulator luxr family L083_6147 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) L083_6153 ENOG4107R9S Malate synthase L083_6155 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) L083_6159 ENOG4105CQ7 ATP-dependent helicase L083_6162 ENOG4105BZU Histidine kinase L083_6177 ENOG4105BZU Histidine kinase L083_6180 ENOG4105C8Q Methyl-accepting chemotaxis L083_6182 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) L083_6184 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) L083_6192 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) L083_6194 ENOG4105BZ1 (ABC) transporter L083_6201 ENOG4105CGS Alpha-glucosidase L083_6203 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 L083_6204 ENOG4105DYW oxidoreductase L083_6205 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) L083_6206 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone L083_6211 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) L083_6214 ENOG4105DZ1 carboxypeptidase L083_6217 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) L083_6218 ENOG4105EEM helicase L083_6219 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) L083_6220 ENOG4105C1J atp-dependent rna helicase L083_6227 ENOG4105ETE Transcriptional regulator (LacI family L083_6231 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component L083_6236 ENOG4105DAG ROK family L083_6238 ENOG4105DYW oxidoreductase L083_6242 ENOG4105NAF rna polymerase sigma factor L083_6244 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) L083_6245 ENOG4105CYP glycoside hydrolase, family L083_6253 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) L083_6254 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) L083_6257 ENOG4105WH1 Two component transcriptional regulator luxr family L083_6260 ENOG4105EB3 Histidine kinase L083_6261 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_6268 ENOG4105ETE Transcriptional regulator (LacI family L083_6271 ENOG4105CHF Glutathione S-transferase L083_6274 ENOG4105KKX ATPase associated with various cellular activities aaa_5 L083_6276 ENOG4105DEG Vwa containing coxe family protein L083_6284 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis L083_6287 ENOG4105D3P Mannan endo-1,4-beta-mannosidase L083_6292 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding L083_6300 ENOG4105KXX peptidase s58 dmpa L083_6301 ENOG4108V9W transcriptional regulatory protein L083_6302 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism L083_6304 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component L083_6305 ENOG4105D2X ABC transporter substrate-binding protein L083_6308 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) L083_6310 ENOG4108UGD Serine Threonine protein kinase L083_6312 ENOG4106F59 XRE family Transcriptional regulator L083_6319 ENOG4105C5T Phosphoribosyl pyrophosphate synthase L083_6320 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) L083_6322 ENOG4108I0Y (ABC) transporter L083_6326 ENOG4105D7N magnesium and cobalt transport protein CorA L083_6327 ENOG4105E1F short-chain dehydrogenase reductase L083_6328 ENOG4105JVQ RNA Polymerase L083_6331 ENOG4105CBG Sulfatase L083_6332 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A L083_6337 ENOG4105DEI Mannitol dehydrogenase L083_6339 ENOG4105D2H Uronic isomerase L083_6341 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component L083_6346 ENOG4105ETE Transcriptional regulator (LacI family L083_6347 ENOG4105DVM PP-loop domain protein L083_6348 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase L083_6349 ENOG4105C8M UPF0272 protein L083_6351 ENOG4108ZGX Histidine kinase L083_6357 ENOG4105KF0 sporulation and cell division protein, SsgA L083_6365 ENOG4105BZU Histidine kinase L083_6368 ENOG410841Q phosphoesterase PA-phosphatase related protein L083_6371 ENOG4105PMW Domain of unknown function (DUF1990) L083_6377 ENOG4106NMR serine protease L083_6380 ENOG4105C0R drug resistance transporter emrb qaca subfamily L083_6381 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_6384 ENOG4108638 50S ribosomal protein L36 L083_6390 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) L083_6393 ENOG4105CYX Short-chain dehydrogenase reductase Sdr L083_6397 ENOG4108UHU Aldolase L083_6400 ENOG4105BZU Histidine kinase L083_6403 ENOG4105CG3 alpha amylase, catalytic region L083_6404 ENOG4105CPK Glycosyl transferase (Group 1 L083_6405 ENOG4105E2K Glycosyl transferase (Group 1 L083_6408 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_6409 ENOG4105D9R oxidoreductase L083_6410 ENOG4105ECR NmrA family L083_6414 ENOG4105K5B UPF0225 protein L083_6415 ENOG4105VUF Transcriptional regulator L083_6416 ENOG4105C8Q Methyl-accepting chemotaxis L083_6417 ENOG4105ETE Transcriptional regulator (LacI family L083_6418 ENOG4105BZ7 extracellular solute-binding protein family 1 L083_6421 ENOG4105CG3 alpha amylase, catalytic region L083_6427 ENOG4105CHH sulfate transporter L083_6429 ENOG4105C0I Conserved Protein L083_6430 ENOG4105CAQ asparagine synthetase L083_6440 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) L083_6441 ENOG4106T9R serine protease L083_6442 ENOG4105C2C drug resistance transporter, Bcr CflA L083_6447 ENOG4105F4R Transcriptional regulator mode L083_6448 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein L083_6455 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) L083_6466 ENOG4108M6P methyltransferase L083_6473 ENOG4108SHN Glycosyl transferase, family 2 L083_6478 ENOG4105D3Q Sugar transferase L083_6480 ENOG4105CJ1 ABC, transporter L083_6483 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) L083_6489 ENOG4105ETE Transcriptional regulator (LacI family L083_6490 ENOG41066UZ arginase EC 3.5.3.1 L083_6491 ENOG4105BZU Histidine kinase L083_6493 ENOG4105WH1 Two component transcriptional regulator luxr family L083_6494 ENOG4105CWX Alpha-1,2-mannosidase L083_6495 ENOG410905P Pyridoxamine 5-phosphate L083_6498 ENOG4105XN3 extracellular solute-binding protein family 1 L083_6499 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component L083_6501 ENOG4105FKQ transcriptional regulator L083_6505 ENOG4105CWX Alpha-1,2-mannosidase L083_6506 ENOG4105BZU Histidine kinase L083_6508 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) L083_6515 ENOG4105ETE Transcriptional regulator (LacI family L083_6528 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) L083_6533 ENOG4105CTK cobaltochelatase, cobn subunit L083_6535 ENOG41081F0 Precorrin-8x methylmutase L083_6540 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase L083_6541 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C L083_6542 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein L083_6544 ENOG4105CJ2 (LipO)protein L083_6546 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_6551 ENOG4105MHT Transcriptional regulator, ARSR family L083_6554 ENOG4105D17 glycoside hydrolase, family 3 domain protein L083_6555 ENOG4105BZU Histidine kinase L083_6560 ENOG4105EYF MMPL domain protein L083_6574 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) L083_6575 ENOG4105CHR reductase L083_6576 ENOG4105WH1 Two component transcriptional regulator luxr family L083_6580 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component L083_6581 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component L083_6583 ENOG4108SU4 UPF0309 protein L083_6584 ENOG4106KNT transcriptional regulator L083_6589 ENOG4105CPQ Dehydrogenase L083_6591 ENOG4106S2D Transcriptional regulator L083_6592 ENOG4105CEY Amp-dependent synthetase and ligase L083_6598 ENOG4105C7W Xanthine dehydrogenase L083_6599 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding L083_6600 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit L083_6605 ENOG4105FDP GntR family transcriptional regulator L083_6606 ENOG4107R7A Allophanate hydrolase subunit 2 L083_6607 ENOG4105P4J Allophanate hydrolase, subunit 1 L083_6608 ENOG4105CFM UPF0317 protein L083_6609 ENOG4105E7W lamb ycsf family protein L083_6610 ENOG4105C5A transporter L083_6611 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) L083_6612 ENOG4105BZU Histidine kinase L083_6624 ENOG4105EYH Exonuclease L083_6625 ENOG4107RH8 nuclease SbcCD subunit D L083_6628 ENOG4105ETE Transcriptional regulator (LacI family L083_6632 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) L083_6642 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein L083_6647 ENOG4108SGK Tetr family transcriptional regulator L083_6652 ENOG4107JEE Short-chain dehydrogenase reductase Sdr L083_6660 ENOG4105C1Q protoporphyrinogen oxidase L083_6661 ENOG4107JTW chlorite dismutase L083_6662 ENOG4108KB2 LysR family Transcriptional regulator L083_6663 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr L083_6666 ENOG4105CS1 NAD(P)H quinone oxidoreductase L083_6669 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) L083_6670 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) L083_6674 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) L083_6675 ENOG4105CHU acetyl-coa acetyltransferase L083_6676 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase L083_6679 ENOG4106F60 Histidine kinase L083_6680 ENOG4105F44 Two component transcriptional regulator, winged helix family L083_6684 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) L083_6685 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) L083_6686 ENOG4105C0X amino acid L083_6687 ENOG4107VEG TrkA-N domain protein L083_6693 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) L083_6702 ENOG4105EN6 Membrane L083_6704 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) L083_6707 ENOG4105BZU Histidine kinase L083_6709 ENOG4105BZU Histidine kinase L083_6712 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) L083_6717 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha L083_6718 ENOG4105DGU Histone deacetylase L083_6726 ENOG4106UW1 Major Facilitator superfamily L083_6728 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) L083_6729 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) L083_6733 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) L083_6737 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) L083_6739 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) L083_6740 ENOG4105C99 atpase involved in dna repair L083_6742 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) L083_6743 ENOG4105NPE arsR family transcriptional regulator L083_6745 ENOG4105KVH Transcriptional regulator L083_6747 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) L083_6749 ENOG4105CDA abc transporter atp-binding protein L083_6750 ENOG4107UBR Extracellular solute-binding protein family 3 L083_6751 ENOG4108Q1T ABC transporter L083_6752 ENOG4105DRP amino acid AbC transporter L083_6753 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) L083_6758 ENOG4105KC9 Modulates RecA activity (By similarity) L083_6759 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) L083_6761 ENOG4108UN4 phage SPO1 DNA polymerase-related protein L083_6765 ENOG4108N23 SpoOM-related protein L083_6766 ENOG4105C37 (CBS) domain L083_6768 ENOG4105D9P serine threonine protein kinase L083_6771 ENOG4107QRT dEAD DEAH box helicase L083_6774 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) L083_6779 ENOG4105WBV Transcriptional regulator L083_6780 ENOG4105CEV competence damage-inducible protein L083_6782 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) L083_6784 ENOG4107QZI cell division protein FtsK L083_6786 ENOG4106T9R serine protease L083_6787 ENOG4105CN5 Metallo-Beta-Lactamase L083_6788 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) L083_6790 ENOG4105T0Z Conserved Protein L083_6792 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) L083_6794 ENOG4105C1V Peptidase, M16 L083_6795 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) L083_6797 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) L083_6799 ENOG4105BZU Histidine kinase L083_6800 ENOG4105EEX Two component transcriptional regulator (Winged helix family L083_6801 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) L083_6805 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) L083_6808 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) L083_6811 ENOG4105CHV Transcription elongation factor NusA L083_6813 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) L083_6820 ENOG4108Z86 Glutamine amidotransferase L083_6821 ENOG4108Z86 Glutamine amidotransferase L083_6823 ENOG4105C26 Dehydrogenase L083_6830 ENOG4108IUX (ABC) transporter L083_6831 ENOG4105RHA ABC transporter, permease L083_6832 ENOG4107Z3H Transcriptional regulator, TetR family L083_6833 ENOG4105ECB domain protein L083_6834 ENOG4105FDK ABC transporter L083_6837 ENOG4105VDT -acetyltransferase L083_6839 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) L083_6845 ENOG4107B57 rieske 2fe-2S domain-containing protein L083_6848 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs L083_6850 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) L083_6851 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) L083_6852 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) L083_6853 ENOG4105CE9 30S ribosomal protein S2 L083_6855 ENOG41080R2 UPF0102 protein L083_6856 ENOG4105C0P Mg chelatase subunit ChlI L083_6863 ENOG4107791 aminotransferase class V L083_6866 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) L083_6867 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) L083_6870 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) L083_6871 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) L083_6872 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) L083_6873 ENOG41082KU UPF0109 protein L083_6874 ENOG4105K5M 30s ribosomal protein S16 L083_6883 ENOG4105C39 capsular polysaccharide phosphotransferase L083_6884 ENOG4107QQG Dehydrogenase L083_6885 ENOG4105EXC Acyl-transferase L083_6888 ENOG4105K64 Glycosyl transferase, family 2 L083_6889 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) L083_6903 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) L083_6905 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) L083_6906 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) L083_6907 ENOG41084BZ 50S ribosomal protein L32 L083_6910 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) L083_6911 ENOG4106H78 methyltransferase L083_6916 ENOG4105DP4 dak2 domain fusion protein ylov L083_6917 ENOG4105VB9 50S ribosomal protein l28 L083_6918 ENOG4108MJ3 acetyltransferase L083_6924 ENOG4105CZV ABC transporter L083_6925 ENOG4105FDP GntR family transcriptional regulator L083_6927 ENOG4105C28 cystathionine L083_6928 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase L083_6929 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) L083_6932 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) L083_6936 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) L083_6943 ENOG4105VZ8 Transcriptional regulator L083_6945 ENOG4108M15 ABC transporter L083_6948 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) L083_6949 ENOG4106F60 Histidine kinase L083_6950 ENOG4105F44 Two component transcriptional regulator, winged helix family L083_6954 ENOG4107RSM transcriptional regulator L083_6958 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) L083_6961 ENOG4105CM2 brancheD-chain amino acid aminotransferase L083_6962 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) L083_6964 ENOG4108JQ1 Dehydrogenase L083_6967 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase L083_6968 ENOG4108ZP8 Acetolactate synthase small subunit L083_6970 ENOG4105C01 Dihydroxy-acid dehydratase L083_6971 ENOG4105BZU Histidine kinase L083_6976 ENOG4105BZU Histidine kinase L083_6978 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) L083_6980 ENOG4105EG2 ABC transporter, permease L083_6983 ENOG4105ETE Transcriptional regulator (LacI family L083_6988 ENOG4105BZU Histidine kinase L083_6995 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) L083_6996 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) L083_6997 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) L083_6998 ENOG4105BZU Histidine kinase L083_6999 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) L083_7001 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) L083_7003 ENOG4105C10 Electron transfer flavoprotein L083_7006 ENOG4105VG5 Membrane L083_7010 ENOG4105CFG Acts as a chaperone (By similarity) L083_7015 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor L083_7016 ENOG4105C8Q Methyl-accepting chemotaxis L083_7017 ENOG4108RVA ribokinase L083_7018 ENOG4105DKW ABC transporter L083_7020 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) L083_7026 ENOG4105C7I Dehydrogenase L083_7028 ENOG41066UZ arginase EC 3.5.3.1 L083_7031 ENOG4105BZU Histidine kinase L083_7032 ENOG4105BZU Histidine kinase L083_7034 ENOG4105DJT lAO AO transport system ATPase L083_7035 ENOG4105CHU acetyl-coa acetyltransferase L083_7047 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) L083_7050 ENOG4105EC2 ftsk spoIIIe L083_7052 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase L083_7054 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) L083_7059 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) L083_7060 ENOG4108KGH TRANSCRIPTIONal L083_7061 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) L083_7062 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) L083_7063 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) L083_7064 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) L083_7065 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) L083_7066 ENOG4106DE0 ATP synthase L083_7067 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) L083_7070 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) L083_7071 ENOG4105CGD Nad-dependent epimerase dehydratase L083_7074 ENOG4105KJF protein tyrosine phosphatase L083_7075 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) L083_7076 ENOG4105BZU Histidine kinase L083_7079 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) L083_7080 ENOG4105VFB Binds the 23S rRNA (By similarity) L083_7085 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) L083_7088 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) L083_7090 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) L083_7091 ENOG4105D6E homoserine dehydrogenase L083_7092 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) L083_7093 ENOG4105C75 arginyL-tRNA synthetase L083_7099 ENOG4105E0A ABC, transporter L083_7100 ENOG4105EHG Permease protein L083_7101 ENOG4105DQ5 transport system permease protein L083_7102 ENOG4108HUF Transporter L083_7103 ENOG4105D9P serine threonine protein kinase L083_7107 ENOG4105C84 Histidine ammonia-lyase L083_7112 ENOG4105ETX regulatoR L083_7113 ENOG4105BZU Histidine kinase L083_7116 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase L083_7119 ENOG4105ECQ AraC Family Transcriptional Regulator L083_7125 ENOG4105KK4 UPF0060 membrane protein L083_7134 ENOG4105RNG membrane L083_7135 ENOG4105K6V RNA polymerase L083_7142 ENOG4108RWP Major Facilitator Superfamily protein L083_7146 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_7149 ENOG4105CHR reductase L083_7150 ENOG4105CEY Amp-dependent synthetase and ligase L083_7151 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP L083_7153 ENOG4105WH1 Two component transcriptional regulator luxr family L083_7157 ENOG41079KZ Major Facilitator Superfamily L083_7159 ENOG4106032 Glutathionylspermidine synthase L083_7162 ENOG4105CG3 alpha amylase, catalytic region L083_7165 ENOG4107T5V SNARE associated Golgi L083_7167 ENOG4106UDK Cellulose-binding, family II L083_7170 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) L083_7171 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase L083_7173 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) L083_7178 ENOG4105CIK Amidinotransferase L083_7179 ENOG4105C8Y Acetylornithine aminotransferase L083_7181 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) L083_7185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) L083_7188 ENOG4105BZU Histidine kinase L083_7189 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_7192 ENOG4105CJ1 ABC, transporter L083_7194 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 L083_7197 ENOG4105EMU Dehydrogenase L083_7198 ENOG4105C6K Malic enzyme L083_7199 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) L083_7201 ENOG4105DQ4 alcohol dehydrogenase L083_7204 ENOG4108VEQ Superoxide dismutase L083_7206 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) L083_7207 ENOG4105FDP GntR family transcriptional regulator L083_7209 ENOG4105CBD Diacylglycerol kinase L083_7213 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) L083_7219 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) L083_7221 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit L083_7223 ENOG4105EMN RNA polymerase sigma factor L083_7226 ENOG4108RAV Conserved protein L083_7227 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase L083_7228 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) L083_7229 ENOG4107TK4 histidinol-phosphate phosphatase L083_7233 ENOG4105WH1 Two component transcriptional regulator luxr family L083_7248 ENOG4105DDN Pentapeptide repeat-containing protein L083_7253 ENOG4105DJZ UPF0182 protein L083_7254 ENOG41063PX domain protein L083_7261 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) L083_7262 ENOG4105D9U N-acetyltransferase L083_7263 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) L083_7267 ENOG4105E09 nadh pyrophosphatase L083_7270 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family L083_7273 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component L083_7277 ENOG4105VEQ Cold shock protein L083_7280 ENOG4105C4R Atp-dependent dna helicase L083_7280 ENOG4105C4R Atp-dependent dna helicase L083_7281 ENOG4105ETE Transcriptional regulator (LacI family L083_7282 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) L083_7285 ENOG4108URH decarboxylase L083_7295 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) L083_7298 ENOG4105BZU Histidine kinase L083_7300 ENOG4105E2K Glycosyl transferase (Group 1 L083_7314 ENOG4107QQG Dehydrogenase L083_7318 ENOG4105CND Glycosyl transferase, family 2 L083_7321 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) L083_7323 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) L083_7324 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) L083_7330 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) L083_7332 ENOG4107QPH glycogen) synthase L083_7337 ENOG4105D3Q Sugar transferase L083_7340 ENOG4105C6Y Udp-glucose 6-dehydrogenase L083_7348 ENOG41061H0 Monooxygenase L083_7354 ENOG4105CV8 reductase L083_7365 ENOG4108Z4U Ferredoxin L083_7366 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) L083_7369 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) L083_7373 ENOG4106TD9 Diguanylate cyclase L083_7378 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) L083_7386 ENOG4105C0Z ABC transporter L083_7387 ENOG4108IV0 ABC, transporter L083_7389 ENOG4105CF8 branched-chain amino acid ABC transporter, permease L083_7391 ENOG4105CHR reductase L083_7394 ENOG4105C1G acyl-Coa dehydrogenase L083_7396 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) L083_7397 ENOG4108V75 Glutamine amidotransferase L083_7398 ENOG41067HS methyltransferase L083_7399 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process L083_7404 ENOG4105C1G acyl-Coa dehydrogenase L083_7405 ENOG4105CEY Amp-dependent synthetase and ligase L083_7414 ENOG4107YFT Nadph-dependent fmn reductase L083_7437 ENOG4105C3G gtp-binding protein L083_7440 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) L083_7442 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) L083_7449 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) L083_7450 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) L083_7453 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) L083_7455 ENOG41061H0 Monooxygenase L083_7465 ENOG4108IAB Phoh family L083_7466 ENOG4105VNY Trehalose 6-phosphate phosphatase L083_7468 ENOG4105P52 geranylgeranyl reductase L083_7470 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) L083_7476 ENOG4105D8K carboxyl transferase L083_7478 ENOG4107WR6 Maf-like protein L083_7486 ENOG4108JIK carboxylase L083_7495 ENOG4107RM1 amidohydrolase L083_7496 ENOG4105D5P Methylmalonyl-coA mutase L083_7498 ENOG4107TPY serine threonine protein kinase L083_7499 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain L083_7502 ENOG4107SJB teichoic acid biosynthesis L083_7503 ENOG4108Z4K mutator MutT protein L083_7504 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) L083_7505 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) L083_7506 ENOG4105C26 Dehydrogenase L083_7507 ENOG4105C26 Dehydrogenase L083_7515 ENOG4105GWZ Roadblock lc7 family protein L083_7519 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) L083_7525 ENOG4105UIB (ABC) transporter L083_7526 ENOG4108JQ9 ABC transporter L083_7527 ENOG4105DIH basic membrane L083_7530 ENOG4108Q5F Tetr family transcriptional regulator L083_7534 ENOG4105CMR udp-glucose 4-epimerase L083_7535 ENOG4105C31 Tryptophanyl-tRNA synthetase L083_7536 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) L083_7540 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo L083_7542 ENOG4105D3Q Sugar transferase L083_7543 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) L083_7544 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) L083_7546 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) L083_7554 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) L083_7557 ENOG41067SE Tetr family transcriptional regulator L083_7560 ENOG4105C5H ABC transporter L083_7561 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) L083_7563 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) L083_7565 ENOG4105F8V Hydrolase, tatD family L083_7571 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) L083_7576 ENOG4105CND Glycosyl transferase, family 2 L083_7579 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) L083_7585 ENOG4105CVM Molybdenum cofactor synthesis domain protein L083_7586 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase L083_7587 ENOG4105BZU Histidine kinase L083_7588 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase L083_7598 ENOG4108KQ5 Integrase catalytic subunit L083_7599 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein L083_7600 ENOG4105DB7 PHP domain protein L083_7606 ENOG41080RH Thioredoxin L083_7608 ENOG4105K4P CoA-binding domain protein L083_7616 ENOG4105JAB phenazine biosynthesis protein, phzf family L083_7617 ENOG4105CJW magnesium transporter L083_7621 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) L083_7622 ENOG4105C0H protease L083_7623 ENOG4107ZBN O-methyltransferase L083_7624 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) L083_7627 ENOG4108UKI Enoyl-CoA hydratase L083_7630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) L083_7633 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain L083_7634 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein L083_7635 ENOG4105DQU oxidoreductase, subunit beta L083_7636 ENOG4107PBV potassium channel L083_7644 ENOG4105D52 delta-aminolevulinic acid dehydratase L083_7645 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) L083_7646 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) L083_7647 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) L083_7648 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) L083_7651 ENOG4105CEY Amp-dependent synthetase and ligase L083_7658 ENOG41062BK proline dehydrogenase L083_7659 ENOG4105EY0 Xylose isomerase domain protein TIM barrel L083_7665 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) L083_7667 ENOG4108V3W Chemotaxis protein, CheW L083_7668 ENOG4107SDU Methyl-accepting chemotaxis L083_7672 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) L083_7678 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin L083_7679 ENOG41065SU Two-component system sensor kinase L083_7683 ENOG4105E4C Lytic transglycosylase catalytic L083_7684 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) L083_7685 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) L083_7687 ENOG4105E1Q flagellar hook-associated protein L083_7689 ENOG4105I03 Flagellin L083_7691 ENOG4105MQ3 flagellar protein FliS L083_7693 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) L083_7694 ENOG4108ZC9 flagellar basal-body rod protein flgc L083_7695 ENOG41084Q6 flagellar hook-basal body complex protein fliE L083_7696 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) L083_7697 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) L083_7702 ENOG4105G2Y Transcriptional regulator L083_7704 ENOG4105E4C Lytic transglycosylase catalytic L083_7706 ENOG4105W00 Flagellar hook capping protein L083_7707 ENOG4105BZE flagellar hook protein, FlgE L083_7709 ENOG4105E14 MotA TolQ exbB proton channel L083_7710 ENOG4106VK6 Flagellar motor protein L083_7712 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) L083_7713 ENOG4105DD5 Flagellar motor switch protein L083_7715 ENOG4105CN7 Flagellar biosynthetic protein FliP L083_7716 ENOG4105D19 Role in flagellar biosynthesis (By similarity) L083_7717 ENOG4105D00 flagellar biosynthetic protein flhB L083_7718 ENOG4105D7B Flagellar biosynthesis protein flha L083_7723 ENOG4108VYJ response regulator receiver protein L083_7726 ENOG4105BZU Histidine kinase L083_7727 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) L083_7729 ENOG4105YFD chemotaxis, protein L083_7730 ENOG4105CBS Chea signal transduction histidine kinase L083_7731 ENOG4108KXV response regulator L083_7732 ENOG4105BZU Histidine kinase L083_7734 ENOG4107R4N Cell wall formation (By similarity) L083_7737 ENOG4105ETE Transcriptional regulator (LacI family L083_7738 ENOG4105EXN Sulfate transport protein CysZ L083_7747 ENOG4105I3K Ferric uptake regulator, Fur family L083_7748 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands L083_7751 ENOG4105PKJ carbohydrate binding L083_7752 ENOG4105KHC sulfurtransferase L083_7755 ENOG4107NHD transcriptional regulator L083_7756 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) L083_7757 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) L083_7759 ENOG4105DXB Major Facilitator superfamily L083_7761 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) L083_7763 ENOG4105E2Z phosphate ABC transporter (Permease L083_7764 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) L083_7765 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) L083_7769 ENOG4105CJ3 phosphate transporter L083_7777 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) L083_7784 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) L083_7786 ENOG4107SJB teichoic acid biosynthesis L083_7787 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase L083_7789 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) L083_7790 ENOG4105CJ1 ABC, transporter L083_7795 ENOG4105CJ1 ABC, transporter L083_7797 ENOG4105XUP Phage derived protein Gp49-like (DUF891) L083_7799 ENOG4105E98 transcriptional regulator DeoR family L083_7800 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) L083_7801 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) L083_7803 ENOG4105CE4 GlcNAc 6-P deacetylase L083_7808 ENOG4105C9Q fumarate hydratase class II L083_7810 ENOG4105C8N cysteinyl-tRNA synthetase L083_7811 ENOG4105C2N RNA methyltransferase TrmH family group 3 L083_7812 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB L083_7813 ENOG4108IJ9 (ABC) transporter L083_7814 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) L083_7818 ENOG4107GFK fumarate L083_7821 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase L083_7824 ENOG4105CIH Imidazole acetol-phosphate transaminase L083_7834 ENOG4105E2R ROK family L083_7836 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) L083_7837 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) L083_7842 ENOG4105FDT acyl-CoA dehydrogenase L083_7843 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) L083_7846 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) L083_7847 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) L083_7849 ENOG4105CEN a g-specific adenine glycosylase L083_7852 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit L083_7855 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) L083_7857 ENOG4108IYU L-aspartate oxidase L083_7859 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) L083_7861 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) L083_7863 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) L083_7866 ENOG4105E90 ABC transporter L083_7867 ENOG4105R40 Glycine betaine carnitine choline L083_7868 ENOG4108IJ8 ABC transporter L083_7875 ENOG4105EEI dihydropteroate synthase L083_7881 ENOG4105DR5 peptidase L083_7884 ENOG4105EC2 ftsk spoIIIe L083_7887 ENOG4105EUJ GTP cyclohydrolase i L083_7888 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) L083_7889 ENOG4108UGV hypoxanthine phosphoribosyltransferase L083_7890 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) L083_7894 ENOG4105F0N pyrophosphate phospho-hydrolase L083_7896 ENOG4105EC2 ftsk spoIIIe L083_7899 ENOG4105P8F nudix hydrolase L083_7900 ENOG4107ZT5 Thiol disulfide interchange protein L083_7901 ENOG4105CSM endonuclease III L083_7902 ENOG4105PNM synthesis protein L083_7904 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) L083_7906 ENOG4105F8J Adenylate Guanylate cyclase L083_7908 ENOG4105KME endoribonuclease L-psp L083_7915 ENOG4105KTH gatB Yqey L083_7917 ENOG4105E2D ec 3.2.1.52 L083_7920 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) L083_7922 ENOG4105CFH Aspartokinase L083_7928 ENOG4105BZU Histidine kinase L083_7930 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) L083_7931 ENOG4105VF7 tolerance protein L083_7932 ENOG4108Z6Z Transcriptional regulator L083_7935 ENOG4108JQ7 (ABC) transporter L083_7936 ENOG4105C3U ABC transporter L083_7939 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component L083_7940 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) L083_7941 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) L083_7945 ENOG4108JGH Tetr family transcriptional regulator L083_7951 ENOG4107R5R arsenical pump membrane protein L083_7953 ENOG4108Z6B deaminase L083_7954 ENOG4105D3A purine nucleoside phosphorylase DeoD-type L083_7956 ENOG4107T65 Integrase L083_7957 ENOG4106CY5 excisionase L083_7970 ENOG4105EVN Prephenate dehydrogenase L083_7978 ENOG4105DCG PHP domain protein L083_7982 ENOG4105DHQ Histidine kinase L083_7983 ENOG4105GWZ Roadblock lc7 family protein L083_7988 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) L083_7993 ENOG4107QJZ Glycosyl transferase, family 2 L083_7994 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase L083_8004 ENOG4105BZU Histidine kinase L083_8015 ENOG4105C8V SAICAR synthetase L083_8019 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_8021 ENOG41065SU Two-component system sensor kinase L083_8036 ENOG4105WH1 Two component transcriptional regulator luxr family L083_8037 ENOG4105BZU Histidine kinase L083_8040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family L083_8041 ENOG4105BZU Histidine kinase L083_8043 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_8044 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) L083_8047 ENOG41066UM arsR family transcriptional regulator L083_8048 ENOG4108UXE Protein tyrosine phosphatase L083_8057 ENOG4105BZU Histidine kinase L083_8058 ENOG4105WH1 Two component transcriptional regulator luxr family L083_8061 ENOG4105PDP Short chain dehydrogenase L083_8062 ENOG4105K4T epimerase L083_8064 ENOG4105SUT Transcriptional Regulator AraC Family L083_8068 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) L083_8072 ENOG4108V1U phospholipid-binding protein L083_8073 ENOG4105BZU Histidine kinase L083_8078 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) L083_8082 ENOG4106UDK Cellulose-binding, family II L083_8085 ENOG4108MDK Dehydrogenase L083_8089 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family L083_8090 ENOG4105D7N magnesium and cobalt transport protein CorA L083_8093 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) L083_8095 ENOG4105CHU acetyl-coa acetyltransferase L083_8099 ENOG4108Z4X TRANSCRIPTIONal L083_8102 ENOG4105E2K Glycosyl transferase (Group 1 L083_8104 ENOG4105D3Q Sugar transferase L083_8106 ENOG4108HRK Histidine kinase L083_8107 ENOG4108NEV two component transcriptional regulator, LytTR family L083_8109 ENOG4105EB3 Histidine kinase L083_8112 ENOG4106SPC secreted protein L083_8115 ENOG4105C31 Tryptophanyl-tRNA synthetase L083_8118 ENOG4107QN1 sodium solute L083_8119 ENOG4108IAJ Nad-dependent epimerase dehydratase L083_8120 ENOG4107TB5 TRANSCRIPTIONal L083_8121 ENOG4108KGH TRANSCRIPTIONal L083_8122 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) L083_8124 ENOG4105BZU Histidine kinase L083_8126 ENOG4105CEU Arginine dihydrolase L083_8132 ENOG4105VUF Transcriptional regulator L083_8133 ENOG4105DQ4 alcohol dehydrogenase L083_8136 ENOG4108Z9K Osmotically inducible protein L083_8138 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) L083_8139 ENOG4105J7I hydrolase L083_8140 ENOG4108K4B hydrolase L083_8141 ENOG4108VC7 Protein of unknown function (DUF2587) L083_8142 ENOG4105CIK Amidinotransferase L083_8143 ENOG4108VVK transcriptional Regulator, AsnC L083_8147 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) L083_8148 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) L083_8149 ENOG4105DGI Alkaline phosphatase L083_8153 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) L083_8155 ENOG4107RN3 metallophosphoesterase L083_8157 ENOG4106A3R peptidase L083_8164 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) L083_8165 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) L083_8166 ENOG4105BZU Histidine kinase L083_8178 ENOG4105K9Q Binds to the 23S rRNA (By similarity) L083_8179 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) L083_8181 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) L083_8186 ENOG4105BZ4 penicillin-binding protein L083_8197 ENOG4105C3M thioredoxin reductase L083_8198 ENOG4105K63 Thioredoxin L083_8199 ENOG4108E1C hydrolase L083_8200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family L083_8202 ENOG4105CPF Cell wall formation (By similarity) L083_8206 ENOG4107QJE Chromosome Partitioning Protein L083_8207 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) L083_8209 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins L083_8210 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) L083_8211 ENOG4107MT9 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) L083_8212 ENOG41084CH 50S ribosomal protein l34