locus-tag	class	description
L083_0002	COG0592	DNA-directed DNA polymerase activity
L083_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L083_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L083_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
L083_0007	COG0187	DNA topoisomerase II activity
L083_0009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L083_0018	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L083_0027	COG1595	DNA-templated transcription, initiation
L083_0029	COG1131	(ABC) transporter
L083_0034	COG0439	Biotin carboxylase
L083_0035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L083_0036	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L083_0037	COG1960	acyl-CoA dehydrogenase activity
L083_0039	COG1846	Transcriptional regulator
L083_0040	COG2353	YceI-like domain
L083_0048	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L083_0050	COG1716	ATPase activity
L083_0050	COG1716	ATPase activity
L083_0051	COG1716	ATPase activity
L083_0054	COG0768	penicillin binding
L083_0055	COG0515	serine threonine protein kinase
L083_0056	COG0515	serine threonine protein kinase
L083_0056	COG2815	serine threonine protein kinase
L083_0058	COG2181	nitrate reductase activity
L083_0058	COG0247	lactate metabolic process
L083_0075	COG0717	Belongs to the dCTP deaminase family
L083_0078	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L083_0079	COG2208	phosphoserine phosphatase activity
L083_0079	COG2770	Histidine kinase
L083_0081	COG1960	acyl-CoA dehydrogenase activity
L083_0083	COG2062	phosphohistidine phosphatase, SixA
L083_0085	COG0702	epimerase
L083_0092	COG0508	dehydrogenase complex catalyzes the overall conversion of
L083_0093	COG0022	dehydrogenase e1 component
L083_0100	COG0443	Heat shock 70 kDa protein
L083_0102	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L083_0103	COG0484	heat shock protein binding
L083_0104	COG0789	Transcriptional regulator
L083_0106	COG0475	glutathione-regulated potassium exporter activity
L083_0106	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L083_0109	COG0542	response to heat
L083_0113	COG0640	Transcriptional regulator
L083_0114	COG0586	Pfam SNARE associated Golgi protein
L083_0115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L083_0124	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L083_0125	COG0151	Belongs to the GarS family
L083_0129	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L083_0130	COG0583	DNA-binding transcription factor activity
L083_0132	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L083_0133	COG0047	phosphoribosylformylglycinamidine synthase activity
L083_0134	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L083_0139	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L083_0140	COG0641	radical SAM
L083_0141	COG0789	Transcriptional regulator
L083_0144	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L083_0148	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
L083_0152	COG2050	protein possibly involved in aromatic compounds catabolism
L083_0159	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_0165	COG0582	viral genome integration into host DNA
L083_0168	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L083_0178	COG0277	FAD linked oxidase domain protein
L083_0182	COG1136	(ABC) transporter
L083_0183	COG4585	Histidine kinase
L083_0185	COG3831	ATPase activity
L083_0186	COG0714	Associated with various cellular activities
L083_0187	COG2197	response regulator
L083_0188	COG2425	protein containing a von Willebrand factor type A (vWA) domain
L083_0189	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L083_0190	COG4715	Zinc finger, swim domain protein
L083_0209	COG3293	Transposase
L083_0223	COG2814	Major facilitator Superfamily
L083_0234	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_0235	COG1028	Short-chain dehydrogenase reductase Sdr
L083_0237	COG0667	Aldo Keto reductase
L083_0243	COG0442	prolyl-tRNA aminoacylation
L083_0247	COG1668	transmembrane transport
L083_0248	COG4152	abc transporter atp-binding protein
L083_0250	COG0515	serine threonine protein kinase
L083_0257	COG1454	alcohol dehydrogenase
L083_0258	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_0267	COG2304	oxidoreductase activity
L083_0270	COG0714	Associated with various cellular activities
L083_0271	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_0276	COG3511	phospholipase C
L083_0282	COG0745	RESPONSE REGULATOR receiver
L083_0283	COG2202	Pas domain
L083_0283	COG2205	protein histidine kinase activity
L083_0284	COG2172	sigma factor antagonist activity
L083_0286	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_0287	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_0289	COG1970	mechanosensitive ion channel activity
L083_0301	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L083_0302	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L083_0307	COG1309	transcriptional regulator
L083_0308	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_0309	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L083_0310	COG0406	alpha-ribazole phosphatase activity
L083_0311	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L083_0312	COG0785	Cytochrome C biogenesis protein
L083_0313	COG1333	cytochrome c biogenesis protein
L083_0314	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L083_0315	COG1733	regulation of RNA biosynthetic process
L083_0318	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L083_0322	COG0163	prenyltransferase activity
L083_0324	COG1522	sequence-specific DNA binding
L083_0328	COG0513	Belongs to the DEAD box helicase family
L083_0395	COG4974	Belongs to the 'phage' integrase family
L083_0396	COG0791	NLP P60 protein
L083_0396	COG3883	PFAM NLP P60 protein
L083_0397	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L083_0402	COG3973	AAA domain
L083_0405	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L083_0410	COG0667	Aldo Keto reductase
L083_0412	COG4279	zinc finger
L083_0413	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L083_0414	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L083_0415	COG2226	methyltransferase
L083_0419	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_0420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_0421	COG0649	NAD binding
L083_0423	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L083_0424	COG1034	ATP synthesis coupled electron transport
L083_0425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L083_0426	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_0428	COG0713	ATP synthesis coupled electron transport
L083_0431	COG1007	ATP synthesis coupled electron transport
L083_0434	COG1414	Transcriptional regulator
L083_0438	COG1950	PFAM Membrane protein of
L083_0443	COG0596	Alpha beta hydrolase
L083_0445	COG3291	Pkd domain containing protein
L083_0445	COG4412	M6 family metalloprotease domain protein
L083_0446	COG3291	Pkd domain containing protein
L083_0446	COG4412	M6 family metalloprotease domain protein
L083_0447	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L083_0460	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_0461	COG1205	dead DEAH box helicase
L083_0461	COG1111	helicase
L083_0463	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L083_0466	COG1754	DNA topoisomerase type I activity
L083_0466	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L083_0468	COG1309	transcriptional regulator
L083_0470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L083_0471	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L083_0476	COG1774	PSP1 C-terminal conserved region
L083_0480	COG1595	DNA-templated transcription, initiation
L083_0497	COG0693	protein deglycase activity
L083_0500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L083_0501	COG1793	dna ligase
L083_0501	COG3285	dna ligase
L083_0502	COG1793	dna ligase
L083_0502	COG3285	dna ligase
L083_0505	COG1061	Type III restriction enzyme res subunit
L083_0509	COG1278	Cold shock
L083_0510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L083_0511	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L083_0513	COG2814	Major facilitator Superfamily
L083_0515	COG2252	PERMEase
L083_0516	COG1846	Transcriptional regulator
L083_0517	COG2814	Major facilitator Superfamily
L083_0518	COG2186	Transcriptional regulator
L083_0519	COG2807	transmembrane transport
L083_0523	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L083_0525	COG0259	pyridoxamine-phosphate oxidase activity
L083_0527	COG2017	converts alpha-aldose to the beta-anomer
L083_0530	COG1960	acyl-CoA dehydrogenase activity
L083_0535	COG1121	(ABC) transporter
L083_0537	COG4585	Histidine kinase
L083_0538	COG2197	response regulator
L083_0541	COG1216	Glycosyl transferase, family 2
L083_0542	COG3842	ATPase activity
L083_0548	COG0667	Aldo Keto reductase
L083_0553	COG1388	LysM domain
L083_0553	COG1134	teichoic acid transport
L083_0555	COG5001	Diguanylate cyclase
L083_0559	COG3706	GGDEF domain
L083_0566	COG0477	Major facilitator Superfamily
L083_0574	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_0575	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_0576	COG1129	ABC transporter
L083_0593	COG1674	ftsk spoiiie
L083_0597	COG0464	growth
L083_0598	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L083_0600	COG3903	Transcriptional regulator
L083_0600	COG3629	intracellular signal transduction
L083_0602	COG2197	response regulator
L083_0606	COG0477	Major facilitator Superfamily
L083_0608	COG0745	RESPONSE REGULATOR receiver
L083_0609	COG1595	DNA-templated transcription, initiation
L083_0611	COG1131	(ABC) transporter
L083_0614	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
L083_0617	COG1086	Polysaccharide biosynthesis protein
L083_0618	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L083_0624	COG0463	Glycosyl transferase, family 2
L083_0633	COG1216	Glycosyl transferase, family 2
L083_0635	COG2089	acid synthase
L083_0639	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L083_0640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L083_0648	COG0395	ABC-type sugar transport system, permease component
L083_0649	COG1063	alcohol dehydrogenase
L083_0658	COG2119	membrane
L083_0665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L083_0665	COG2213	PTS system mannitol-specific
L083_0666	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L083_0666	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L083_0668	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L083_0669	COG1942	4-Oxalocrotonate Tautomerase
L083_0670	COG1028	Short-chain dehydrogenase reductase Sdr
L083_0672	COG1253	flavin adenine dinucleotide binding
L083_0676	COG0745	RESPONSE REGULATOR receiver
L083_0676	COG3706	GGDEF domain
L083_0687	COG0586	Pfam SNARE associated Golgi protein
L083_0689	COG1793	dna ligase
L083_0689	COG3285	dna ligase
L083_0691	COG1064	alcohol dehydrogenase
L083_0694	COG1309	transcriptional regulator
L083_0701	COG1028	Short-chain dehydrogenase reductase Sdr
L083_0702	COG0667	Aldo Keto reductase
L083_0705	COG5001	Diguanylate cyclase
L083_0707	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L083_0719	COG2207	Transcriptional regulator
L083_0724	COG0247	lactate metabolic process
L083_0725	COG1139	Iron-sulfur cluster binding protein
L083_0726	COG1556	Lactate utilization protein
L083_0728	COG0667	Aldo Keto reductase
L083_0735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L083_0736	COG3795	YCII-related domain
L083_0737	COG4941	Belongs to the sigma-70 factor family
L083_0738	COG1082	Xylose isomerase domain protein TIM barrel
L083_0739	COG0501	Belongs to the peptidase M48B family
L083_0740	COG0242	peptide deformylase activity
L083_0741	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L083_0742	COG2124	cytochrome p450
L083_0743	COG0009	L-threonylcarbamoyladenylate synthase
L083_0776	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_0778	COG1309	transcriptional regulator
L083_0783	COG4251	negative regulation of phosphorylation
L083_0784	COG2205	protein histidine kinase activity
L083_0784	COG0784	Response regulator, receiver
L083_0794	COG0438	transferase activity, transferring glycosyl groups
L083_0795	COG1215	transferase activity, transferring glycosyl groups
L083_0803	COG0745	RESPONSE REGULATOR receiver
L083_0804	COG2200	EAL domain
L083_0804	COG3287	FIST C domain
L083_0804	COG2199	diguanylate cyclase activity
L083_0810	COG1175	transmembrane transport
L083_0818	COG0583	DNA-binding transcription factor activity
L083_0822	COG0402	S-adenosylhomocysteine deaminase activity
L083_0823	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L083_0824	COG1414	Transcriptional regulator
L083_0828	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L083_0829	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L083_0830	COG2205	protein histidine kinase activity
L083_0831	COG0745	RESPONSE REGULATOR receiver
L083_0832	COG2124	cytochrome p450
L083_0840	COG0745	RESPONSE REGULATOR receiver
L083_0841	COG4251	negative regulation of phosphorylation
L083_0842	COG0784	Response regulator, receiver
L083_0843	COG0483	inositol monophosphate 1-phosphatase activity
L083_0844	COG1028	Short-chain dehydrogenase reductase Sdr
L083_0847	COG0515	serine threonine protein kinase
L083_0847	COG2815	serine threonine protein kinase
L083_0848	COG0569	domain protein
L083_0849	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L083_0850	COG1028	Short-chain dehydrogenase reductase Sdr
L083_0852	COG3103	Sh3 type 3 domain protein
L083_0852	COG0791	NLP P60 protein
L083_0852	COG1388	LysM domain
L083_0853	COG1937	Protein conserved in bacteria
L083_0856	COG5398	heme oxygenase
L083_0858	COG0513	Belongs to the DEAD box helicase family
L083_0862	COG0596	Alpha beta hydrolase
L083_0868	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L083_0870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L083_0873	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_0879	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L083_0881	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_0883	COG0713	ATP synthesis coupled electron transport
L083_0885	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_0886	COG1007	ATP synthesis coupled electron transport
L083_0887	COG0501	Belongs to the peptidase M48B family
L083_0891	COG1028	Short-chain dehydrogenase reductase Sdr
L083_0894	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_0896	COG2258	MOSC domain
L083_0903	COG1666	GTP binding
L083_0906	COG3300	MHYT domain
L083_0906	COG5001	Diguanylate cyclase
L083_0907	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L083_0908	COG2030	dehydratase
L083_0910	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L083_0912	COG0081	regulation of translation
L083_0914	COG0222	ribosome binding
L083_0915	COG0085	RNA polymerase activity
L083_0916	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L083_0919	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L083_0920	COG0049	tRNA binding
L083_0921	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L083_0922	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L083_0923	COG0051	transcription antitermination factor activity, RNA binding
L083_0924	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L083_0925	COG0088	Forms part of the polypeptide exit tunnel
L083_0927	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L083_0928	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L083_0929	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L083_0930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L083_0931	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L083_0932	COG0255	Belongs to the universal ribosomal protein uL29 family
L083_0933	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L083_0934	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L083_0935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L083_0936	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L083_0937	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L083_0938	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L083_0939	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L083_0940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L083_0941	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L083_0942	COG1841	ribosomal large subunit assembly
L083_0943	COG0200	Binds to the 23S rRNA
L083_0945	COG0563	adenylate kinase activity
L083_0949	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L083_0950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L083_0951	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L083_0952	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L083_0953	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L083_0955	COG0203	ribosomal protein L17
L083_0956	COG0101	tRNA pseudouridine synthase activity
L083_0960	COG2813	Specifically methylates the guanine in position
L083_0961	COG0488	(ABC) transporter
L083_0962	COG0352	thiamine-phosphate diphosphorylase activity
L083_0965	COG2022	thiamine diphosphate biosynthetic process
L083_0966	COG0352	thiamine-phosphate diphosphorylase activity
L083_0967	COG0351	phosphomethylpyrimidine kinase
L083_0968	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L083_0973	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_0976	COG2018	Roadblock/LC7 domain
L083_0980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L083_0981	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L083_0982	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L083_0984	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_0988	COG0736	holo-[acyl-carrier-protein] synthase activity
L083_0990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L083_0992	COG0802	atpase or kinase
L083_0993	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L083_0995	COG0456	acetyltransferase
L083_0996	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L083_0998	COG1132	(ABC) transporter
L083_0999	COG1132	(ABC) transporter
L083_1004	COG4214	carbohydrate transport
L083_1007	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L083_1009	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L083_1010	COG0459	protein refolding
L083_1014	COG2197	response regulator
L083_1022	COG1316	TRANSCRIPTIONal
L083_1025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L083_1025	COG0519	Catalyzes the synthesis of GMP from XMP
L083_1027	COG1051	belongs to the nudix hydrolase family
L083_1028	COG0494	nUDIX hydrolase
L083_1029	COG1183	phosphatidylcholine synthase activity
L083_1030	COG0688	phosphatidylethanolamine metabolic process
L083_1035	COG0747	negative chemotaxis
L083_1037	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_1039	COG4608	Belongs to the ABC transporter superfamily
L083_1040	COG1605	Chorismate mutase
L083_1041	COG0737	Belongs to the 5'-nucleotidase family
L083_1041	COG1525	nuclease
L083_1041	COG4085	toxin activity
L083_1043	COG4942	peptidase
L083_1045	COG0739	heme binding
L083_1046	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_1047	COG0045	succinate-CoA ligase (ADP-forming) activity
L083_1051	COG0138	bifunctional purine biosynthesis protein purh
L083_1056	COG0538	isocitrate dehydrogenase activity
L083_1058	COG1349	DNA-binding transcription factor activity
L083_1061	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L083_1069	COG0529	Catalyzes the synthesis of activated sulfate
L083_1078	COG1131	(ABC) transporter
L083_1080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L083_1082	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L083_1082	COG1024	Enoyl-CoA hydratase
L083_1089	COG0148	phosphopyruvate hydratase activity
L083_1092	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L083_1100	COG0714	Associated with various cellular activities
L083_1103	COG1252	NADH dehydrogenase
L083_1107	COG0183	Belongs to the thiolase family
L083_1112	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_1118	COG2326	polyphosphate kinase activity
L083_1119	COG1234	tRNA 3'-trailer cleavage
L083_1122	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L083_1127	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L083_1128	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L083_1130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L083_1134	COG1331	Highly conserved protein containing a thioredoxin domain
L083_1139	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_1142	COG1607	acyl-coa hydrolase
L083_1143	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L083_1148	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
L083_1148	COG0662	Cupin 2, conserved barrel domain protein
L083_1150	COG0778	Nitroreductase
L083_1150	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
L083_1155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L083_1160	COG1012	belongs to the aldehyde dehydrogenase family
L083_1162	COG1012	belongs to the aldehyde dehydrogenase family
L083_1166	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L083_1167	COG1663	tetraacyldisaccharide 4'-kinase activity
L083_1167	COG2835	tetraacyldisaccharide 4'-kinase activity
L083_1173	COG0745	RESPONSE REGULATOR receiver
L083_1174	COG5002	protein histidine kinase activity
L083_1174	COG5000	phosphorelay sensor kinase activity
L083_1177	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L083_1178	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_1180	COG0653	protein targeting
L083_1183	COG1522	sequence-specific DNA binding
L083_1188	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L083_1189	COG2884	Cell division ATP-binding protein ftsE
L083_1191	COG0739	heme binding
L083_1191	COG0741	lytic transglycosylase activity
L083_1191	COG1196	nuclear chromosome segregation
L083_1192	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L083_1198	COG0737	Belongs to the 5'-nucleotidase family
L083_1199	COG1678	Uncharacterized ACR, COG1678
L083_1202	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_1203	COG1802	Transcriptional regulator
L083_1211	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L083_1213	COG1459	type II secretion system
L083_1215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L083_1216	COG4977	sequence-specific DNA binding
L083_1238	COG0778	Nitroreductase
L083_1242	COG1953	Uracil, thiamine, allantoin
L083_1249	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L083_1250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L083_1253	COG5001	Diguanylate cyclase
L083_1253	COG5002	protein histidine kinase activity
L083_1259	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_1262	COG3285	dna ligase
L083_1262	COG1793	dna ligase
L083_1264	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_1265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L083_1269	COG1335	isochorismatase
L083_1270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L083_1271	COG2197	response regulator
L083_1273	COG0667	Aldo Keto reductase
L083_1278	COG1234	tRNA 3'-trailer cleavage
L083_1279	COG0438	transferase activity, transferring glycosyl groups
L083_1280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L083_1281	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L083_1284	COG4941	Belongs to the sigma-70 factor family
L083_1286	COG2986	histidine ammonia-lyase
L083_1287	COG1228	amidohydrolase
L083_1288	COG1228	amidohydrolase
L083_1289	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_1290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L083_1293	COG0633	Ferredoxin
L083_1293	COG3217	Mosc domain protein beta barrel domain protein
L083_1307	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L083_1312	COG0477	Major facilitator Superfamily
L083_1331	COG1376	ErfK ybiS ycfS ynhG family protein
L083_1337	COG0784	Response regulator, receiver
L083_1338	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_1348	COG1522	sequence-specific DNA binding
L083_1352	COG0456	acetyltransferase
L083_1352	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L083_1357	COG0640	Transcriptional regulator
L083_1361	COG2124	cytochrome p450
L083_1371	COG3629	intracellular signal transduction
L083_1371	COG3903	Transcriptional regulator
L083_1374	COG2706	6-phosphogluconolactonase activity
L083_1376	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_1380	COG2115	Belongs to the xylose isomerase family
L083_1381	COG1070	Carbohydrate kinase
L083_1382	COG0366	Alpha amylase catalytic
L083_1383	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L083_1390	COG1028	Short-chain dehydrogenase reductase Sdr
L083_1405	COG2197	response regulator
L083_1408	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_1421	COG0629	single-stranded DNA binding
L083_1422	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L083_1423	COG1492	cobalamin metabolic process
L083_1425	COG0501	Belongs to the peptidase M48B family
L083_1426	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_1429	COG1793	dna ligase
L083_1433	COG1797	cobyrinic acid a,c-diamide synthase activity
L083_1437	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L083_1438	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L083_1438	COG1648	precorrin-2 dehydrogenase activity
L083_1440	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L083_1449	COG0668	transmembrane transport
L083_1459	COG0698	ribose 5-phosphate isomerase
L083_1461	COG4552	Acetyltransferase involved in intracellular survival and related
L083_1468	COG1028	Short-chain dehydrogenase reductase Sdr
L083_1470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_1471	COG3903	Transcriptional regulator
L083_1471	COG3629	intracellular signal transduction
L083_1477	COG2226	methyltransferase
L083_1478	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_1481	COG1028	Short-chain dehydrogenase reductase Sdr
L083_1486	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_1489	COG0492	ferredoxin-NADP+ reductase activity
L083_1492	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L083_1493	COG3959	Transketolase, thiamine diphosphate binding domain
L083_1494	COG0673	inositol 2-dehydrogenase activity
L083_1498	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L083_1499	COG0544	peptidyl-prolyl cis-trans isomerase activity
L083_1500	COG0740	serine-type endopeptidase activity
L083_1501	COG0740	serine-type endopeptidase activity
L083_1502	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L083_1503	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L083_1506	COG0525	valine-tRNA ligase activity
L083_1507	COG0285	dihydrofolate synthase activity
L083_1510	COG0105	UTP biosynthetic process
L083_1513	COG3046	protein related to deoxyribodipyrimidine photolyase
L083_1515	COG0596	Alpha beta hydrolase
L083_1517	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_1520	COG1530	ribonuclease E activity
L083_1522	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L083_1523	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L083_1524	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L083_1530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L083_1531	COG0799	negative regulation of ribosome biogenesis
L083_1532	COG0406	alpha-ribazole phosphatase activity
L083_1534	COG1307	EDD domain protein, DegV family
L083_1537	COG1596	polysaccharide export
L083_1537	COG1555	photosystem II stabilization
L083_1538	COG2333	competence protein COMEC
L083_1538	COG0658	competence protein
L083_1541	COG1090	epimerase
L083_1546	COG0268	Binds directly to 16S ribosomal RNA
L083_1550	COG0481	GTPase activity
L083_1551	COG2261	transglycosylase associated protein
L083_1554	COG1024	Enoyl-CoA hydratase
L083_1557	COG1420	regulation of RNA biosynthetic process
L083_1558	COG0484	heat shock protein binding
L083_1560	COG2249	NAD(P)H dehydrogenase (quinone) activity
L083_1562	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_1563	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_1564	COG1120	ATPase activity
L083_1567	COG1132	(ABC) transporter
L083_1573	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L083_1575	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L083_1580	COG0667	Aldo Keto reductase
L083_1582	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L083_1583	COG3547	Transposase (IS116 IS110 IS902 family)
L083_1583	COG3547	Transposase (IS116 IS110 IS902 family)
L083_1587	COG1028	Short-chain dehydrogenase reductase Sdr
L083_1590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L083_1592	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L083_1596	COG1381	Involved in DNA repair and RecF pathway recombination
L083_1597	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L083_1604	COG2353	YceI-like domain
L083_1610	COG0596	Alpha beta hydrolase
L083_1616	COG1122	ATPase activity
L083_1617	COG4721	ABC-type cobalt transport system, permease component
L083_1622	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L083_1623	COG1121	(ABC) transporter
L083_1628	COG0423	glycine-tRNA ligase activity
L083_1630	COG5002	protein histidine kinase activity
L083_1642	COG3608	succinylglutamate desuccinylase aspartoacylase
L083_1642	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L083_1652	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L083_1653	COG0358	DNA primase activity
L083_1655	COG1131	(ABC) transporter
L083_1657	COG0842	Transport permease protein
L083_1662	COG1129	ABC transporter
L083_1663	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_1675	COG0583	DNA-binding transcription factor activity
L083_1690	COG1396	sequence-specific DNA binding
L083_1694	COG1404	Belongs to the peptidase S8 family
L083_1694	COG4412	M6 family metalloprotease domain protein
L083_1704	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_1709	COG1404	Belongs to the peptidase S8 family
L083_1718	COG0840	transmembrane signaling receptor activity
L083_1721	COG0018	arginyl-trna synthetase
L083_1727	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L083_1728	COG1268	BioY protein
L083_1731	COG0714	Associated with various cellular activities
L083_1739	COG0737	Belongs to the 5'-nucleotidase family
L083_1741	COG0515	serine threonine protein kinase
L083_1745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L083_1749	COG3973	AAA domain
L083_1751	COG0288	reversible hydration of carbon dioxide
L083_1755	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_1760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L083_1761	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L083_1768	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L083_1771	COG2814	Major facilitator Superfamily
L083_1773	COG0840	transmembrane signaling receptor activity
L083_1774	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L083_1775	COG0432	Pfam Uncharacterised protein family UPF0047
L083_1782	COG3509	depolymerase
L083_1790	COG2197	response regulator
L083_1794	COG0492	ferredoxin-NADP+ reductase activity
L083_1798	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L083_1800	COG0328	RNA-DNA hybrid ribonuclease activity
L083_1800	COG0406	alpha-ribazole phosphatase activity
L083_1812	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L083_1812	COG0235	Class ii aldolase
L083_1813	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L083_1817	COG2197	response regulator
L083_1818	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L083_1820	COG0475	glutathione-regulated potassium exporter activity
L083_1822	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_1823	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L083_1824	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L083_1825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L083_1829	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_1831	COG2226	methyltransferase
L083_1836	COG1028	Short-chain dehydrogenase reductase Sdr
L083_1836	COG0604	alcohol dehydrogenase
L083_1836	COG3321	synthase
L083_1838	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L083_1839	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L083_1839	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L083_1840	COG0174	glutamine synthetase
L083_1841	COG3766	membrane
L083_1842	COG0456	acetyltransferase
L083_1844	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L083_1849	COG1733	regulation of RNA biosynthetic process
L083_1853	COG2207	Transcriptional regulator
L083_1854	COG0667	Aldo Keto reductase
L083_1856	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L083_1857	COG0017	Asparaginyl-tRNA synthetase
L083_1858	COG0321	lipoyl(octanoyl) transferase activity
L083_1863	COG0508	dehydrogenase complex catalyzes the overall conversion of
L083_1864	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L083_1866	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L083_1867	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L083_1868	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L083_1869	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L083_1871	COG1994	Peptidase M50
L083_1872	COG0667	Aldo Keto reductase
L083_1877	COG4555	ABC transporter
L083_1879	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L083_1882	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L083_1883	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L083_1889	COG0425	Belongs to the sulfur carrier protein TusA family
L083_1890	COG1104	cysteine desulfurase activity
L083_1891	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L083_1896	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L083_1900	COG2010	Cytochrome c
L083_1902	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L083_1906	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L083_1908	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L083_1912	COG0501	Belongs to the peptidase M48B family
L083_1913	COG0438	transferase activity, transferring glycosyl groups
L083_1918	COG2072	flavoprotein involved in K transport
L083_1920	COG1940	carbohydrate kinase activity
L083_1924	COG2197	response regulator
L083_1925	COG0431	NADPH-dependent FMN reductase
L083_1936	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L083_1939	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L083_1943	COG0454	-acetyltransferase
L083_1943	COG0456	acetyltransferase
L083_1947	COG0583	DNA-binding transcription factor activity
L083_1949	COG1053	succinate dehydrogenase
L083_1950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L083_1959	COG0142	geranyltranstransferase activity
L083_1964	COG0515	serine threonine protein kinase
L083_1964	COG2815	serine threonine protein kinase
L083_1965	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L083_1968	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_1979	COG0745	RESPONSE REGULATOR receiver
L083_1992	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_1994	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L083_2000	COG0714	Associated with various cellular activities
L083_2001	COG0495	leucyl-tRNA aminoacylation
L083_2002	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L083_2003	COG3226	Transcriptional regulator
L083_2007	COG3442	glutamine amidotransferase
L083_2008	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L083_2010	COG2001	Belongs to the MraZ family
L083_2011	COG0275	rRNA processing
L083_2013	COG0768	penicillin binding
L083_2016	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L083_2018	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L083_2019	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L083_2020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L083_2021	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L083_2022	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L083_2024	COG1799	cell septum assembly
L083_2026	COG3599	regulation of cell shape
L083_2029	COG3263	regulation of cellular component size
L083_2031	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L083_2035	COG0587	DNA-directed DNA polymerase activity
L083_2036	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L083_2037	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L083_2038	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L083_2039	COG0131	Imidazoleglycerol-phosphate dehydratase
L083_2041	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L083_2043	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L083_2044	COG0107	imidazoleglycerol-phosphate synthase activity
L083_2045	COG2205	protein histidine kinase activity
L083_2046	COG0745	RESPONSE REGULATOR receiver
L083_2048	COG1017	nitric oxide dioxygenase activity
L083_2048	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L083_2050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L083_2052	COG1022	Amp-dependent synthetase and ligase
L083_2055	COG2205	protein histidine kinase activity
L083_2056	COG0745	RESPONSE REGULATOR receiver
L083_2060	COG1132	(ABC) transporter
L083_2061	COG1132	(ABC) transporter
L083_2062	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L083_2066	COG0667	Aldo Keto reductase
L083_2080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L083_2081	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L083_2083	COG0667	Aldo Keto reductase
L083_2086	COG0134	indole-3-glycerol-phosphate synthase activity
L083_2087	COG0133	tryptophan synthase activity
L083_2088	COG0159	tryptophan synthase activity
L083_2089	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L083_2092	COG0070	glutamate synthase
L083_2092	COG0069	glutamate synthase activity
L083_2092	COG0067	glutamate synthase
L083_2103	COG1946	Acyl-CoA thioesterase
L083_2113	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_2114	COG0765	amino acid transport
L083_2115	COG1126	abc transporter atp-binding protein
L083_2122	COG2226	methyltransferase
L083_2123	COG0539	negative regulation of cytoplasmic translation
L083_2125	COG0237	dephospho-CoA kinase activity
L083_2125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L083_2128	COG0861	Integral membrane protein TerC family
L083_2131	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L083_2132	COG0740	serine-type endopeptidase activity
L083_2133	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_2135	COG1162	GTPase activity
L083_2137	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L083_2139	COG0322	excinuclease ABC activity
L083_2140	COG1660	Displays ATPase and GTPase activities
L083_2142	COG1481	regulation of sporulation
L083_2144	COG0583	DNA-binding transcription factor activity
L083_2145	COG2223	nitrite transmembrane transporter activity
L083_2147	COG1309	transcriptional regulator
L083_2148	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L083_2149	COG0126	phosphoglycerate kinase activity
L083_2150	COG0149	triose-phosphate isomerase activity
L083_2151	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L083_2153	COG0456	acetyltransferase
L083_2158	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_2164	COG0363	glucosamine-6-phosphate deaminase activity
L083_2167	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L083_2170	COG0109	protoheme IX farnesyltransferase activity
L083_2176	COG0719	Fe-S assembly protein
L083_2178	COG0396	ATPase activity
L083_2179	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L083_2180	COG0822	iron-sulfur transferase activity
L083_2181	COG2151	metal-sulfur cluster biosynthetic enzyme
L083_2182	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_2191	COG0789	Transcriptional regulator
L083_2192	COG0659	secondary active sulfate transmembrane transporter activity
L083_2193	COG1132	(ABC) transporter
L083_2198	COG0748	coenzyme F420 binding
L083_2199	COG1309	transcriptional regulator
L083_2200	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2202	COG3663	DNA glycosylase
L083_2205	COG3220	belongs to the UPF0276 family
L083_2207	COG1309	transcriptional regulator
L083_2214	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L083_2229	COG0006	proline dipeptidase activity
L083_2239	COG0714	Associated with various cellular activities
L083_2243	COG2304	oxidoreductase activity
L083_2247	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L083_2252	COG3226	Transcriptional regulator
L083_2256	COG1051	belongs to the nudix hydrolase family
L083_2267	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L083_2276	COG1012	belongs to the aldehyde dehydrogenase family
L083_2277	COG0506	proline dehydrogenase activity
L083_2283	COG1365	unkown
L083_2284	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L083_2287	COG1175	transmembrane transport
L083_2289	COG0395	ABC-type sugar transport system, permease component
L083_2296	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_2299	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L083_2303	COG1846	Transcriptional regulator
L083_2305	COG0494	nUDIX hydrolase
L083_2306	COG2197	response regulator
L083_2307	COG4585	Histidine kinase
L083_2311	COG1309	transcriptional regulator
L083_2313	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L083_2316	COG1012	belongs to the aldehyde dehydrogenase family
L083_2318	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_2324	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L083_2325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_2331	COG2271	Major facilitator Superfamily
L083_2335	COG0477	Major facilitator Superfamily
L083_2337	COG3629	intracellular signal transduction
L083_2338	COG1597	lipid kinase activity
L083_2343	COG0318	PFAM AMP-dependent synthetase and ligase
L083_2349	COG1595	DNA-templated transcription, initiation
L083_2353	COG2409	Drug exporters of the RND superfamily
L083_2355	COG1309	transcriptional regulator
L083_2356	COG2267	carboxylic ester hydrolase activity
L083_2369	COG0667	Aldo Keto reductase
L083_2370	COG1609	Transcriptional regulator
L083_2377	COG2205	protein histidine kinase activity
L083_2379	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L083_2384	COG0456	acetyltransferase
L083_2385	COG0436	Aminotransferase
L083_2388	COG0745	RESPONSE REGULATOR receiver
L083_2391	COG1215	transferase activity, transferring glycosyl groups
L083_2396	COG2770	Histidine kinase
L083_2396	COG2208	phosphoserine phosphatase activity
L083_2399	COG0671	phosphoesterase, PA-phosphatase related
L083_2405	COG1522	sequence-specific DNA binding
L083_2411	COG0714	Associated with various cellular activities
L083_2422	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2423	COG1309	transcriptional regulator
L083_2425	COG3012	SEC-C Motif Domain Protein
L083_2428	COG1914	H( )-stimulated, divalent metal cation uptake system
L083_2429	COG3546	catalase activity
L083_2430	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L083_2434	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L083_2441	COG2197	response regulator
L083_2446	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_2448	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2449	COG2124	cytochrome p450
L083_2451	COG0477	Major facilitator Superfamily
L083_2464	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L083_2468	COG0738	Major facilitator superfamily
L083_2469	COG1349	DNA-binding transcription factor activity
L083_2481	COG2116	formate transmembrane transporter activity
L083_2498	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_2499	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L083_2500	COG1960	acyl-CoA dehydrogenase activity
L083_2502	COG0604	alcohol dehydrogenase
L083_2502	COG3321	synthase
L083_2503	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_2505	COG2409	Drug exporters of the RND superfamily
L083_2506	COG2226	methyltransferase
L083_2509	COG2197	response regulator
L083_2514	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2521	COG5002	protein histidine kinase activity
L083_2528	COG0583	DNA-binding transcription factor activity
L083_2529	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2531	COG1917	Cupin 2, conserved barrel domain protein
L083_2531	COG4977	sequence-specific DNA binding
L083_2532	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L083_2540	COG1309	transcriptional regulator
L083_2558	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L083_2562	COG1733	regulation of RNA biosynthetic process
L083_2573	COG0259	pyridoxamine-phosphate oxidase activity
L083_2576	COG2801	Transposase and inactivated derivatives
L083_2576	COG3415	Transposase
L083_2584	COG1674	ftsk spoiiie
L083_2589	COG3415	Transposase
L083_2589	COG2801	Transposase and inactivated derivatives
L083_2607	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L083_2614	COG5297	Belongs to the glycosyl hydrolase family 6
L083_2614	COG4733	cellulase activity
L083_2615	COG3345	alpha-galactosidase
L083_2620	COG0395	ABC-type sugar transport system, permease component
L083_2622	COG1653	transport
L083_2623	COG1940	carbohydrate kinase activity
L083_2631	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_2634	COG1902	pentaerythritol trinitrate reductase activity
L083_2637	COG2813	Specifically methylates the guanine in position
L083_2640	COG4974	Belongs to the 'phage' integrase family
L083_2655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_2656	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L083_2659	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_2663	COG0477	Major facilitator Superfamily
L083_2665	COG0500	methyltransferase
L083_2670	COG4221	oxidoreductase activity
L083_2673	COG0702	epimerase
L083_2680	COG0395	ABC-type sugar transport system, permease component
L083_2682	COG1609	Transcriptional regulator
L083_2684	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L083_2704	COG3629	intracellular signal transduction
L083_2705	COG0515	serine threonine protein kinase
L083_2705	COG2815	serine threonine protein kinase
L083_2714	COG0745	RESPONSE REGULATOR receiver
L083_2715	COG2205	protein histidine kinase activity
L083_2718	COG2755	lipolytic protein G-D-S-L family
L083_2722	COG1595	DNA-templated transcription, initiation
L083_2723	COG2267	carboxylic ester hydrolase activity
L083_2725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_2733	COG0300	oxidoreductase activity
L083_2735	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2737	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_2738	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L083_2739	COG4221	oxidoreductase activity
L083_2742	COG0444	Belongs to the ABC transporter superfamily
L083_2744	COG0601	transmembrane transport
L083_2754	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_2758	COG0025	NhaP-type Na H and K H
L083_2761	COG3387	PFAM Glycoside hydrolase 15-related
L083_2762	COG1063	alcohol dehydrogenase
L083_2763	COG1252	NADH dehydrogenase
L083_2764	COG0243	molybdopterin cofactor binding
L083_2772	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L083_2775	COG0515	serine threonine protein kinase
L083_2776	COG0515	serine threonine protein kinase
L083_2780	COG1960	acyl-CoA dehydrogenase activity
L083_2785	COG0596	Alpha beta hydrolase
L083_2791	COG0745	RESPONSE REGULATOR receiver
L083_2793	COG2205	protein histidine kinase activity
L083_2794	COG1136	(ABC) transporter
L083_2795	COG1136	(ABC) transporter
L083_2795	COG0577	efflux transmembrane transporter activity
L083_2798	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2800	COG0114	fumarate hydratase activity
L083_2801	COG4221	oxidoreductase activity
L083_2802	COG0840	transmembrane signaling receptor activity
L083_2807	COG1086	Polysaccharide biosynthesis protein
L083_2808	COG0489	protein tyrosine kinase activity
L083_2814	COG0438	transferase activity, transferring glycosyl groups
L083_2825	COG0583	DNA-binding transcription factor activity
L083_2826	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2828	COG3548	integral membrane protein
L083_2829	COG0604	alcohol dehydrogenase
L083_2835	COG1028	Short-chain dehydrogenase reductase Sdr
L083_2839	COG0492	ferredoxin-NADP+ reductase activity
L083_2841	COG2197	response regulator
L083_2842	COG4585	Histidine kinase
L083_2844	COG2197	response regulator
L083_2847	COG2201	protein-glutamate methylesterase activity
L083_2854	COG0745	RESPONSE REGULATOR receiver
L083_2855	COG2205	protein histidine kinase activity
L083_2856	COG0671	phosphoesterase, PA-phosphatase related
L083_2859	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_2860	COG0366	Alpha amylase catalytic
L083_2861	COG0667	Aldo Keto reductase
L083_2862	COG0438	transferase activity, transferring glycosyl groups
L083_2871	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_2872	COG0318	PFAM AMP-dependent synthetase and ligase
L083_2885	COG2409	Drug exporters of the RND superfamily
L083_2887	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L083_2888	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_2889	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L083_2892	COG0546	phosphoglycolate phosphatase activity
L083_2905	COG0778	Nitroreductase
L083_2912	COG2855	membrane
L083_2918	COG0745	RESPONSE REGULATOR receiver
L083_2919	COG5000	phosphorelay sensor kinase activity
L083_2919	COG5002	protein histidine kinase activity
L083_2925	COG2814	Major facilitator Superfamily
L083_2929	COG5002	protein histidine kinase activity
L083_2929	COG2205	protein histidine kinase activity
L083_2929	COG0784	Response regulator, receiver
L083_2931	COG1063	alcohol dehydrogenase
L083_2938	COG2409	Drug exporters of the RND superfamily
L083_2947	COG0446	pyridine nucleotide-disulphide oxidoreductase
L083_2951	COG3345	alpha-galactosidase
L083_2955	COG2226	methyltransferase
L083_2956	COG2226	methyltransferase
L083_2967	COG0251	oxidation-reduction process
L083_2969	COG2423	ornithine cyclodeaminase activity
L083_2970	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_2973	COG0602	queuosine metabolic process
L083_2974	COG0720	synthase
L083_2975	COG0302	gtp cyclohydrolase
L083_2977	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L083_2990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L083_2992	COG2197	response regulator
L083_3002	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_3005	COG2264	protein methyltransferase activity
L083_3006	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_3007	COG0745	RESPONSE REGULATOR receiver
L083_3008	COG5002	protein histidine kinase activity
L083_3011	COG5001	Diguanylate cyclase
L083_3011	COG3300	MHYT domain
L083_3025	COG2084	Dehydrogenase
L083_3032	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_3034	COG2226	methyltransferase
L083_3035	COG3850	Histidine kinase
L083_3035	COG5002	protein histidine kinase activity
L083_3043	COG2018	Roadblock/LC7 domain
L083_3053	COG2197	response regulator
L083_3055	COG1960	acyl-CoA dehydrogenase activity
L083_3058	COG0438	transferase activity, transferring glycosyl groups
L083_3063	COG1136	(ABC) transporter
L083_3063	COG4591	ABC-type transport system involved in lipoprotein release permease component
L083_3064	COG4591	ABC-type transport system involved in lipoprotein release permease component
L083_3064	COG1136	(ABC) transporter
L083_3069	COG5520	Belongs to the glycosyl hydrolase 30 family
L083_3072	COG1309	transcriptional regulator
L083_3073	COG4221	oxidoreductase activity
L083_3074	COG0179	Fumarylacetoacetate (FAA) hydrolase
L083_3077	COG0129	dihydroxy-acid dehydratase activity
L083_3078	COG1028	Short-chain dehydrogenase reductase Sdr
L083_3085	COG0300	oxidoreductase activity
L083_3087	COG3485	protocatechuate 3,4-dioxygenase
L083_3088	COG1414	Transcriptional regulator
L083_3089	COG3485	protocatechuate 3,4-dioxygenase
L083_3092	COG0477	Major facilitator Superfamily
L083_3100	COG0439	Biotin carboxylase
L083_3101	COG0511	ligase activity, forming carbon-carbon bonds
L083_3102	COG0825	malonyl-CoA metabolic process
L083_3102	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L083_3108	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_3109	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L083_3111	COG1028	Short-chain dehydrogenase reductase Sdr
L083_3115	COG2124	cytochrome p450
L083_3121	COG0367	asparagine synthase
L083_3122	COG1819	glycosyl
L083_3123	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L083_3125	COG1819	glycosyl
L083_3128	COG1028	Short-chain dehydrogenase reductase Sdr
L083_3130	COG2084	Dehydrogenase
L083_3131	COG2345	Transcriptional regulator
L083_3133	COG0493	'glutamate synthase
L083_3134	COG3104	oligopeptide transport
L083_3135	COG3629	intracellular signal transduction
L083_3135	COG3903	Transcriptional regulator
L083_3136	COG2133	pyrroloquinoline quinone binding
L083_3138	COG2197	response regulator
L083_3139	COG4585	Histidine kinase
L083_3140	COG1136	(ABC) transporter
L083_3140	COG0577	efflux transmembrane transporter activity
L083_3141	COG0577	efflux transmembrane transporter activity
L083_3146	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L083_3148	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L083_3156	COG3629	intracellular signal transduction
L083_3156	COG3903	Transcriptional regulator
L083_3160	COG1028	Short-chain dehydrogenase reductase Sdr
L083_3164	COG0683	leucine binding
L083_3181	COG3509	depolymerase
L083_3183	COG1175	transmembrane transport
L083_3184	COG0395	ABC-type sugar transport system, permease component
L083_3197	COG0596	Alpha beta hydrolase
L083_3198	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L083_3201	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_3213	COG2124	cytochrome p450
L083_3215	COG2207	Transcriptional regulator
L083_3215	COG3708	Transcriptional regulator
L083_3216	COG1819	glycosyl
L083_3217	COG1819	glycosyl
L083_3219	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L083_3222	COG2124	cytochrome p450
L083_3225	COG0367	asparagine synthase
L083_3227	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L083_3229	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_3231	COG4941	Belongs to the sigma-70 factor family
L083_3237	COG0778	Nitroreductase
L083_3246	COG1733	regulation of RNA biosynthetic process
L083_3247	COG2205	protein histidine kinase activity
L083_3249	COG0745	RESPONSE REGULATOR receiver
L083_3256	COG0366	Alpha amylase catalytic
L083_3256	COG1470	cell adhesion involved in biofilm formation
L083_3260	COG1090	epimerase
L083_3261	COG4213	ABC transporter substrate-binding protein
L083_3263	COG4214	carbohydrate transport
L083_3265	COG3345	alpha-galactosidase
L083_3266	COG3509	depolymerase
L083_3272	COG1404	Belongs to the peptidase S8 family
L083_3274	COG3693	PFAM glycoside hydrolase, family 10
L083_3281	COG2267	carboxylic ester hydrolase activity
L083_3285	COG3458	cephalosporin-C deacetylase activity
L083_3287	COG1028	Short-chain dehydrogenase reductase Sdr
L083_3288	COG1959	2 iron, 2 sulfur cluster binding
L083_3289	COG0726	polysaccharide deacetylase
L083_3290	COG0386	Belongs to the glutathione peroxidase family
L083_3292	COG3537	Alpha-1,2-mannosidase
L083_3293	COG0477	Major facilitator Superfamily
L083_3297	COG1672	PFAM Archaeal ATPase
L083_3297	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L083_3299	COG1028	Short-chain dehydrogenase reductase Sdr
L083_3302	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L083_3302	COG1672	PFAM Archaeal ATPase
L083_3308	COG0596	Alpha beta hydrolase
L083_3313	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L083_3314	COG5001	Diguanylate cyclase
L083_3315	COG0701	Predicted permease
L083_3318	COG0601	transmembrane transport
L083_3319	COG0444	Belongs to the ABC transporter superfamily
L083_3322	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L083_3322	COG2508	Transcriptional regulator
L083_3326	COG4948	Mandelate Racemase Muconate Lactonizing
L083_3337	COG0604	alcohol dehydrogenase
L083_3339	COG0583	DNA-binding transcription factor activity
L083_3340	COG2080	2 iron, 2 sulfur cluster binding
L083_3341	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L083_3342	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L083_3354	COG2205	protein histidine kinase activity
L083_3358	COG1309	transcriptional regulator
L083_3362	COG3903	Transcriptional regulator
L083_3362	COG3629	intracellular signal transduction
L083_3364	COG5002	protein histidine kinase activity
L083_3365	COG0745	RESPONSE REGULATOR receiver
L083_3366	COG1064	alcohol dehydrogenase
L083_3367	COG1376	ErfK ybiS ycfS ynhG family protein
L083_3380	COG1129	ABC transporter
L083_3384	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_3388	COG2807	transmembrane transport
L083_3396	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L083_3398	COG0745	RESPONSE REGULATOR receiver
L083_3399	COG2205	protein histidine kinase activity
L083_3400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L083_3405	COG3409	Peptidoglycan-binding domain 1 protein
L083_3405	COG3757	hydrolase, family 25
L083_3407	COG0588	phosphoglycerate mutase activity
L083_3409	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L083_3410	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L083_3416	COG1131	(ABC) transporter
L083_3417	COG5479	isomerase activity
L083_3417	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L083_3420	COG2239	Acts as a magnesium transporter
L083_3425	COG4109	DRTGG domain
L083_3437	COG1454	alcohol dehydrogenase
L083_3437	COG1012	belongs to the aldehyde dehydrogenase family
L083_3438	COG0589	response to stress
L083_3439	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L083_3446	COG2201	protein-glutamate methylesterase activity
L083_3459	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L083_3462	COG1882	Formate acetyltransferase
L083_3463	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L083_3463	COG0574	Belongs to the PEP-utilizing enzyme family
L083_3464	COG2239	Acts as a magnesium transporter
L083_3466	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L083_3475	COG3537	Alpha-1,2-mannosidase
L083_3476	COG2837	iron assimilation
L083_3478	COG0672	)-iron permease
L083_3480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L083_3484	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L083_3488	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L083_3490	COG0477	Major facilitator Superfamily
L083_3492	COG1733	regulation of RNA biosynthetic process
L083_3494	COG4221	oxidoreductase activity
L083_3495	COG1309	transcriptional regulator
L083_3496	COG0667	Aldo Keto reductase
L083_3509	COG0028	Belongs to the TPP enzyme family
L083_3510	COG0248	Ppx GppA phosphatase
L083_3514	COG3629	intracellular signal transduction
L083_3514	COG3903	Transcriptional regulator
L083_3519	COG1609	Transcriptional regulator
L083_3524	COG1785	Belongs to the alkaline phosphatase family
L083_3539	COG2837	iron assimilation
L083_3542	COG0803	Belongs to the bacterial solute-binding protein 9 family
L083_3543	COG1121	(ABC) transporter
L083_3544	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L083_3547	COG1914	H( )-stimulated, divalent metal cation uptake system
L083_3549	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L083_3554	COG3583	domain protein
L083_3554	COG3584	3D domain protein
L083_3558	COG0477	Major facilitator Superfamily
L083_3561	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L083_3568	COG2367	Beta-lactamase
L083_3569	COG0706	membrane insertase activity
L083_3575	COG0531	amino acid
L083_3579	COG1215	transferase activity, transferring glycosyl groups
L083_3581	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L083_3582	COG1024	Enoyl-CoA hydratase
L083_3593	COG2356	endonuclease I
L083_3595	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L083_3598	COG3119	arylsulfatase activity
L083_3599	COG0823	Involved in the tonB-independent uptake of proteins
L083_3602	COG0823	Involved in the tonB-independent uptake of proteins
L083_3602	COG1506	peptidase
L083_3603	COG3250	beta-galactosidase activity
L083_3615	COG2814	Major facilitator Superfamily
L083_3616	COG1175	transmembrane transport
L083_3617	COG0395	ABC-type sugar transport system, permease component
L083_3624	COG2986	histidine ammonia-lyase
L083_3626	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_3627	COG0439	Biotin carboxylase
L083_3629	COG4221	oxidoreductase activity
L083_3630	COG2197	response regulator
L083_3631	COG0589	response to stress
L083_3635	COG3629	intracellular signal transduction
L083_3635	COG3903	Transcriptional regulator
L083_3639	COG0515	serine threonine protein kinase
L083_3641	COG1132	(ABC) transporter
L083_3642	COG1132	(ABC) transporter
L083_3643	COG2197	response regulator
L083_3644	COG1501	Belongs to the glycosyl hydrolase 31 family
L083_3645	COG1278	Cold shock
L083_3653	COG0297	glycogen (starch) synthase activity
L083_3655	COG1595	DNA-templated transcription, initiation
L083_3656	COG3537	Alpha-1,2-mannosidase
L083_3664	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L083_3665	COG1063	alcohol dehydrogenase
L083_3673	COG1131	(ABC) transporter
L083_3676	COG2357	RelA SpoT domain protein
L083_3678	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L083_3682	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L083_3692	COG0726	polysaccharide deacetylase
L083_3700	COG2070	2-Nitropropane dioxygenase
L083_3701	COG1435	thymidine kinase activity
L083_3709	COG0740	serine-type endopeptidase activity
L083_3710	COG1309	transcriptional regulator
L083_3721	COG2318	DinB family
L083_3723	COG0640	Transcriptional regulator
L083_3725	COG3866	Pectate lyase
L083_3727	COG3629	intracellular signal transduction
L083_3727	COG3903	Transcriptional regulator
L083_3729	COG3386	PFAM SMP-30 Gluconolaconase
L083_3733	COG2201	protein-glutamate methylesterase activity
L083_3735	COG0583	DNA-binding transcription factor activity
L083_3736	COG0477	Major facilitator Superfamily
L083_3739	COG1028	Short-chain dehydrogenase reductase Sdr
L083_3748	COG1609	Transcriptional regulator
L083_3753	COG4948	Mandelate Racemase Muconate Lactonizing
L083_3761	COG3409	Peptidoglycan-binding domain 1 protein
L083_3768	COG3940	Belongs to the glycosyl hydrolase 43 family
L083_3772	COG1609	Transcriptional regulator
L083_3773	COG1879	ABC-type sugar transport system periplasmic component
L083_3775	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_3776	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_3784	COG0673	inositol 2-dehydrogenase activity
L083_3785	COG4948	Mandelate Racemase Muconate Lactonizing
L083_3786	COG0246	Mannitol dehydrogenase
L083_3787	COG1904	glucuronate isomerase
L083_3788	COG0673	inositol 2-dehydrogenase activity
L083_3789	COG1609	Transcriptional regulator
L083_3791	COG1175	transmembrane transport
L083_3792	COG0395	ABC-type sugar transport system, permease component
L083_3796	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L083_3802	COG2133	pyrroloquinoline quinone binding
L083_3803	COG1802	Transcriptional regulator
L083_3805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L083_3808	COG2159	amidohydrolase
L083_3821	COG3022	response to hydroperoxide
L083_3829	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L083_3831	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L083_3832	COG0431	NADPH-dependent FMN reductase
L083_3839	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_3848	COG0243	molybdopterin cofactor binding
L083_3848	COG3383	formate dehydrogenase (NAD+) activity
L083_3849	COG0243	molybdopterin cofactor binding
L083_3849	COG3383	formate dehydrogenase (NAD+) activity
L083_3850	COG0437	4 iron, 4 sulfur cluster binding
L083_3852	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L083_3854	COG0596	Alpha beta hydrolase
L083_3856	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L083_3863	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L083_3878	COG2197	response regulator
L083_3879	COG4585	Histidine kinase
L083_3885	COG0701	Predicted permease
L083_3889	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L083_3891	COG0477	Major facilitator Superfamily
L083_3892	COG1609	Transcriptional regulator
L083_3908	COG1396	sequence-specific DNA binding
L083_3909	COG0745	RESPONSE REGULATOR receiver
L083_3913	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L083_3914	COG1960	acyl-CoA dehydrogenase activity
L083_3916	COG2755	lipolytic protein G-D-S-L family
L083_3916	COG0657	acetylesterase activity
L083_3919	COG2764	glyoxalase bleomycin resistance protein dioxygenase
L083_3924	COG0604	alcohol dehydrogenase
L083_3925	COG1509	lysine 2,3-aminomutase activity
L083_3926	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L083_3927	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L083_3928	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_3929	COG1607	acyl-coa hydrolase
L083_3932	COG0463	Glycosyl transferase, family 2
L083_3949	COG1309	transcriptional regulator
L083_3957	COG0667	Aldo Keto reductase
L083_3959	COG4702	Belongs to the UPF0303 family
L083_3961	COG1846	Transcriptional regulator
L083_3962	COG1764	response to oxidative stress
L083_3963	COG2267	carboxylic ester hydrolase activity
L083_3969	COG1063	alcohol dehydrogenase
L083_3978	COG2197	response regulator
L083_3985	COG1968	undecaprenyl-diphosphatase activity
L083_3986	COG4974	Belongs to the 'phage' integrase family
L083_3988	COG1191	sigma factor activity
L083_3989	COG2197	response regulator
L083_3990	COG4585	Histidine kinase
L083_3992	COG1131	(ABC) transporter
L083_3996	COG0019	diaminopimelate decarboxylase activity
L083_3998	COG0242	peptide deformylase activity
L083_4002	COG1028	Short-chain dehydrogenase reductase Sdr
L083_4003	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L083_4003	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L083_4005	COG0667	Aldo Keto reductase
L083_4008	COG0667	Aldo Keto reductase
L083_4013	COG2272	Belongs to the type-B carboxylesterase lipase family
L083_4017	COG1028	Short-chain dehydrogenase reductase Sdr
L083_4025	COG1716	ATPase activity
L083_4026	COG0509	glycine decarboxylation via glycine cleavage system
L083_4032	COG4867	von Willebrand factor, type A
L083_4033	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
L083_4034	COG0384	phenazine biosynthesis protein PhzF
L083_4036	COG1649	PFAM Uncharacterised BCR, COG1649
L083_4038	COG0297	glycogen (starch) synthase activity
L083_4039	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L083_4045	COG4974	Belongs to the 'phage' integrase family
L083_4050	COG2318	DinB family
L083_4063	COG3415	Transposase
L083_4063	COG2801	Transposase and inactivated derivatives
L083_4066	COG4585	Histidine kinase
L083_4067	COG2197	response regulator
L083_4069	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4075	COG4106	trans-aconitate 2-methyltransferase activity
L083_4081	COG0747	negative chemotaxis
L083_4085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_4086	COG4638	Rieske (2fe-2S)
L083_4089	COG4176	ABC-type proline glycine betaine transport system permease component
L083_4090	COG4175	Glycine betaine
L083_4090	COG0517	IMP dehydrogenase activity
L083_4105	COG1501	Belongs to the glycosyl hydrolase 31 family
L083_4109	COG1609	Transcriptional regulator
L083_4111	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_4112	COG0515	serine threonine protein kinase
L083_4113	COG3201	nicotinamide mononucleotide transporter
L083_4118	COG0583	DNA-binding transcription factor activity
L083_4123	COG1215	transferase activity, transferring glycosyl groups
L083_4136	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L083_4138	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L083_4141	COG2223	nitrite transmembrane transporter activity
L083_4142	COG2146	nitrite reductase [NAD(P)H] activity
L083_4143	COG0243	molybdopterin cofactor binding
L083_4144	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L083_4150	COG0071	Belongs to the small heat shock protein (HSP20) family
L083_4151	COG0745	RESPONSE REGULATOR receiver
L083_4151	COG3706	GGDEF domain
L083_4154	COG0318	PFAM AMP-dependent synthetase and ligase
L083_4157	COG0500	methyltransferase
L083_4160	COG1609	Transcriptional regulator
L083_4161	COG0673	inositol 2-dehydrogenase activity
L083_4168	COG1309	transcriptional regulator
L083_4172	COG0667	Aldo Keto reductase
L083_4174	COG1177	transmembrane transport
L083_4175	COG3842	ATPase activity
L083_4177	COG2936	dipeptidyl-peptidase activity
L083_4188	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L083_4189	COG3842	ATPase activity
L083_4191	COG1176	ABC-type spermidine putrescine transport system, permease component I
L083_4192	COG1177	transmembrane transport
L083_4193	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_4195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4198	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L083_4199	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L083_4200	COG1522	sequence-specific DNA binding
L083_4206	COG1131	(ABC) transporter
L083_4211	COG1012	belongs to the aldehyde dehydrogenase family
L083_4213	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4214	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L083_4214	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L083_4219	COG0535	radical SAM domain protein
L083_4224	COG1131	(ABC) transporter
L083_4226	COG2197	response regulator
L083_4235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4236	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_4238	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L083_4242	COG3706	GGDEF domain
L083_4250	COG3401	FG-GAP repeat protein
L083_4252	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L083_4252	COG3608	succinylglutamate desuccinylase aspartoacylase
L083_4254	COG1802	Transcriptional regulator
L083_4256	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_4263	COG1278	Cold shock
L083_4270	COG2226	methyltransferase
L083_4272	COG0346	lactoylglutathione lyase activity
L083_4278	COG1120	ATPase activity
L083_4282	COG0667	Aldo Keto reductase
L083_4283	COG1233	COG1233 Phytoene dehydrogenase and related
L083_4289	COG3268	Saccharopine dehydrogenase
L083_4291	COG2154	pterin-4-alpha-carbinolamine dehydratase
L083_4296	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L083_4297	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L083_4304	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_4308	COG2409	Drug exporters of the RND superfamily
L083_4310	COG5001	Diguanylate cyclase
L083_4311	COG2267	carboxylic ester hydrolase activity
L083_4317	COG1987	bacterial-type flagellum assembly
L083_4320	COG4213	ABC transporter substrate-binding protein
L083_4325	COG0438	transferase activity, transferring glycosyl groups
L083_4326	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_4330	COG3300	MHYT domain
L083_4330	COG5001	Diguanylate cyclase
L083_4331	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L083_4340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4342	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L083_4349	COG5297	Belongs to the glycosyl hydrolase family 6
L083_4349	COG4733	cellulase activity
L083_4356	COG0395	ABC-type sugar transport system, permease component
L083_4358	COG1609	Transcriptional regulator
L083_4359	COG1652	LysM domain
L083_4361	COG4948	Mandelate Racemase Muconate Lactonizing
L083_4368	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L083_4372	COG0303	'Molybdopterin
L083_4373	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_4378	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L083_4378	COG2080	2 iron, 2 sulfur cluster binding
L083_4380	COG0646	methionine synthase
L083_4380	COG1410	methionine synthase
L083_4381	COG0537	adenosine 5'-monophosphoramidase activity
L083_4382	COG2130	NADP-dependent
L083_4387	COG0326	Molecular chaperone. Has ATPase activity
L083_4389	COG2814	Major facilitator Superfamily
L083_4392	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_4394	COG0583	DNA-binding transcription factor activity
L083_4398	COG1921	L-seryl-tRNASec selenium transferase activity
L083_4403	COG0709	Synthesizes selenophosphate from selenide and ATP
L083_4404	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_4408	COG0438	transferase activity, transferring glycosyl groups
L083_4413	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L083_4416	COG0514	ATP-dependent DNA helicase (RecQ)
L083_4421	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L083_4427	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L083_4428	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L083_4435	COG0277	FAD linked oxidase domain protein
L083_4436	COG0277	FAD linked oxidase domain protein
L083_4437	COG0247	lactate metabolic process
L083_4443	COG2382	esterase
L083_4445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L083_4449	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_4452	COG3300	MHYT domain
L083_4452	COG5001	Diguanylate cyclase
L083_4454	COG0300	oxidoreductase activity
L083_4456	COG0310	cobalt ion transport
L083_4458	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L083_4459	COG1122	ATPase activity
L083_4463	COG1609	Transcriptional regulator
L083_4465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L083_4465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L083_4470	COG0456	acetyltransferase
L083_4480	COG0242	peptide deformylase activity
L083_4488	COG1461	Dihydroxyacetone kinase
L083_4489	COG2376	Dihydroxyacetone kinase
L083_4492	COG1136	(ABC) transporter
L083_4493	COG1136	(ABC) transporter
L083_4502	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L083_4507	COG3706	GGDEF domain
L083_4507	COG0745	RESPONSE REGULATOR receiver
L083_4508	COG3104	oligopeptide transport
L083_4511	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
L083_4513	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_4514	COG4251	negative regulation of phosphorylation
L083_4519	COG1012	belongs to the aldehyde dehydrogenase family
L083_4520	COG0574	Belongs to the PEP-utilizing enzyme family
L083_4520	COG3848	Pyruvate phosphate dikinase
L083_4525	COG0789	Transcriptional regulator
L083_4526	COG3903	Transcriptional regulator
L083_4526	COG3629	intracellular signal transduction
L083_4528	COG1309	transcriptional regulator
L083_4529	COG0477	Major facilitator Superfamily
L083_4531	COG1105	Belongs to the carbohydrate kinase PfkB family
L083_4538	COG1349	DNA-binding transcription factor activity
L083_4539	COG1486	melibiose metabolic process
L083_4540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_4541	COG2182	Extracellular solute-binding protein
L083_4542	COG1175	transmembrane transport
L083_4543	COG0395	ABC-type sugar transport system, permease component
L083_4546	COG3693	PFAM glycoside hydrolase, family 10
L083_4547	COG0442	prolyl-tRNA aminoacylation
L083_4551	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L083_4565	COG0745	RESPONSE REGULATOR receiver
L083_4567	COG4221	oxidoreductase activity
L083_4572	COG1028	Short-chain dehydrogenase reductase Sdr
L083_4576	COG0159	tryptophan synthase activity
L083_4577	COG0133	tryptophan synthase activity
L083_4581	COG5002	protein histidine kinase activity
L083_4581	COG5001	Diguanylate cyclase
L083_4581	COG3447	MASE1 domain protein
L083_4582	COG0791	NLP P60 protein
L083_4582	COG3883	PFAM NLP P60 protein
L083_4583	COG0501	Belongs to the peptidase M48B family
L083_4584	COG1271	oxidase subunit
L083_4586	COG1294	oxidase, subunit
L083_4587	COG4988	ABC transporter
L083_4591	COG1028	Short-chain dehydrogenase reductase Sdr
L083_4592	COG0859	PFAM glycosyl transferase family 9
L083_4593	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L083_4593	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L083_4594	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L083_4595	COG0297	glycogen (starch) synthase activity
L083_4597	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L083_4599	COG2192	nodulation
L083_4603	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4607	COG0667	Aldo Keto reductase
L083_4609	COG0477	Major facilitator Superfamily
L083_4610	COG1309	transcriptional regulator
L083_4612	COG1132	(ABC) transporter
L083_4613	COG1132	(ABC) transporter
L083_4614	COG3708	Transcriptional regulator
L083_4614	COG2207	Transcriptional regulator
L083_4618	COG1609	Transcriptional regulator
L083_4620	COG0583	DNA-binding transcription factor activity
L083_4622	COG0527	aspartate kinase activity
L083_4623	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L083_4624	COG0697	spore germination
L083_4625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_4626	COG4865	methylaspartate mutase activity
L083_4627	COG0745	RESPONSE REGULATOR receiver
L083_4628	COG2205	protein histidine kinase activity
L083_4629	COG2409	Drug exporters of the RND superfamily
L083_4637	COG1175	transmembrane transport
L083_4650	COG1301	dicarboxylic acid transport
L083_4651	COG3290	protein histidine kinase activity
L083_4652	COG4565	transcriptional regulatory protein
L083_4655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_4658	COG1028	Short-chain dehydrogenase reductase Sdr
L083_4659	COG1309	transcriptional regulator
L083_4662	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L083_4663	COG1294	oxidase, subunit
L083_4664	COG4988	ABC transporter
L083_4665	COG1271	oxidase subunit
L083_4666	COG0745	RESPONSE REGULATOR receiver
L083_4667	COG2205	protein histidine kinase activity
L083_4668	COG1028	Short-chain dehydrogenase reductase Sdr
L083_4669	COG1653	transport
L083_4670	COG1175	transmembrane transport
L083_4671	COG0395	ABC-type sugar transport system, permease component
L083_4672	COG3973	AAA domain
L083_4673	COG0058	SHG alpha-glucan phosphorylase activity
L083_4680	COG5002	protein histidine kinase activity
L083_4681	COG4251	negative regulation of phosphorylation
L083_4685	COG4166	transmembrane transport
L083_4686	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_4688	COG4172	Belongs to the ABC transporter superfamily
L083_4692	COG0515	serine threonine protein kinase
L083_4694	COG2175	clavaminate synthase activity
L083_4696	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L083_4697	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_4698	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_4700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L083_4704	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_4713	COG1193	negative regulation of DNA recombination
L083_4713	COG1418	mRNA catabolic process
L083_4715	COG0531	amino acid
L083_4717	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4719	COG0745	RESPONSE REGULATOR receiver
L083_4723	COG0667	Aldo Keto reductase
L083_4725	COG0442	prolyl-tRNA aminoacylation
L083_4730	COG1957	nucleoside hydrolase
L083_4735	COG0589	response to stress
L083_4740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L083_4741	COG3396	Phenylacetate-CoA oxygenase
L083_4742	COG2151	metal-sulfur cluster biosynthetic enzyme
L083_4743	COG3460	Phenylacetate-CoA oxygenase
L083_4744	COG3396	Phenylacetate-CoA oxygenase
L083_4747	COG1309	transcriptional regulator
L083_4753	COG1131	(ABC) transporter
L083_4756	COG2197	response regulator
L083_4757	COG0673	inositol 2-dehydrogenase activity
L083_4763	COG3718	enzyme involved in inositol metabolism
L083_4764	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_4766	COG3384	dioxygenase
L083_4771	COG0861	Integral membrane protein TerC family
L083_4777	COG1136	(ABC) transporter
L083_4777	COG0577	efflux transmembrane transporter activity
L083_4778	COG1136	(ABC) transporter
L083_4779	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L083_4780	COG0745	RESPONSE REGULATOR receiver
L083_4781	COG2205	protein histidine kinase activity
L083_4785	COG2890	protein-(glutamine-N5) methyltransferase activity
L083_4786	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_4787	COG1620	l-lactate permease
L083_4788	COG3469	chitinase activity
L083_4792	COG2814	Major facilitator Superfamily
L083_4793	COG1940	carbohydrate kinase activity
L083_4794	COG0406	alpha-ribazole phosphatase activity
L083_4796	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_4812	COG0166	Belongs to the GPI family
L083_4815	COG1063	alcohol dehydrogenase
L083_4820	COG5001	Diguanylate cyclase
L083_4826	COG2197	response regulator
L083_4845	COG3304	Inner membrane component domain
L083_4846	COG1247	-acetyltransferase
L083_4847	COG4279	zinc finger
L083_4848	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L083_4851	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_4855	COG0531	amino acid
L083_4857	COG0515	serine threonine protein kinase
L083_4863	COG0463	Glycosyl transferase, family 2
L083_4869	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L083_4873	COG0456	acetyltransferase
L083_4882	COG1408	metallophosphoesterase
L083_4904	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_4913	COG0395	ABC-type sugar transport system, permease component
L083_4916	COG2501	S4 domain
L083_4919	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L083_4922	COG1366	Belongs to the anti-sigma-factor antagonist family
L083_4933	COG1940	carbohydrate kinase activity
L083_4935	COG4214	carbohydrate transport
L083_4936	COG1129	ABC transporter
L083_4937	COG4213	ABC transporter substrate-binding protein
L083_4938	COG2160	L-arabinose isomerase activity
L083_4940	COG1609	Transcriptional regulator
L083_4943	COG3940	Belongs to the glycosyl hydrolase 43 family
L083_4953	COG1136	(ABC) transporter
L083_4953	COG0577	efflux transmembrane transporter activity
L083_4959	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L083_4961	COG0840	transmembrane signaling receptor activity
L083_4962	COG0643	Histidine kinase
L083_4962	COG2198	Histidine kinase
L083_4963	COG2201	protein-glutamate methylesterase activity
L083_4964	COG0745	RESPONSE REGULATOR receiver
L083_4964	COG3706	GGDEF domain
L083_4965	COG0577	efflux transmembrane transporter activity
L083_4965	COG1136	(ABC) transporter
L083_4966	COG1136	(ABC) transporter
L083_4966	COG0577	efflux transmembrane transporter activity
L083_4967	COG4585	Histidine kinase
L083_4968	COG2197	response regulator
L083_4974	COG0463	Glycosyl transferase, family 2
L083_4983	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L083_4984	COG0443	Heat shock 70 kDa protein
L083_4990	COG1960	acyl-CoA dehydrogenase activity
L083_4999	COG1309	transcriptional regulator
L083_5003	COG4106	trans-aconitate 2-methyltransferase activity
L083_5005	COG1064	alcohol dehydrogenase
L083_5006	COG5001	Diguanylate cyclase
L083_5006	COG3300	MHYT domain
L083_5007	COG3300	MHYT domain
L083_5007	COG5001	Diguanylate cyclase
L083_5008	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_5013	COG2197	response regulator
L083_5014	COG4585	Histidine kinase
L083_5015	COG2409	Drug exporters of the RND superfamily
L083_5016	COG4677	pectinesterase activity
L083_5025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_5026	COG2030	dehydratase
L083_5034	COG0577	efflux transmembrane transporter activity
L083_5034	COG1136	(ABC) transporter
L083_5035	COG0577	efflux transmembrane transporter activity
L083_5036	COG0318	PFAM AMP-dependent synthetase and ligase
L083_5039	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_5041	COG0515	serine threonine protein kinase
L083_5042	COG0631	protein serine/threonine phosphatase activity
L083_5046	COG0483	inositol monophosphate 1-phosphatase activity
L083_5048	COG4682	membrane
L083_5049	COG4581	dead DEAH box helicase
L083_5050	COG0546	phosphoglycolate phosphatase activity
L083_5055	COG1119	ATPase activity
L083_5056	COG0805	protein transport
L083_5057	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L083_5060	COG2378	regulation of single-species biofilm formation
L083_5066	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L083_5069	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L083_5070	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L083_5072	COG4122	O-methyltransferase activity
L083_5073	COG1222	aaa ATPase
L083_5074	COG1141	Ferredoxin
L083_5077	COG0517	IMP dehydrogenase activity
L083_5077	COG1994	Peptidase M50
L083_5085	COG1136	(ABC) transporter
L083_5086	COG0577	efflux transmembrane transporter activity
L083_5086	COG1136	(ABC) transporter
L083_5087	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_5088	COG0667	Aldo Keto reductase
L083_5090	COG4941	Belongs to the sigma-70 factor family
L083_5092	COG3795	YCII-related domain
L083_5094	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L083_5113	COG0215	cysteine-tRNA ligase activity
L083_5117	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_5118	COG0667	Aldo Keto reductase
L083_5126	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_5128	COG0583	DNA-binding transcription factor activity
L083_5129	COG0542	response to heat
L083_5133	COG1674	ftsk spoiiie
L083_5143	COG0745	RESPONSE REGULATOR receiver
L083_5149	COG0653	protein targeting
L083_5150	COG1132	(ABC) transporter
L083_5152	COG0673	inositol 2-dehydrogenase activity
L083_5153	COG0463	Glycosyl transferase, family 2
L083_5156	COG2201	protein-glutamate methylesterase activity
L083_5159	COG1191	sigma factor activity
L083_5177	COG1797	cobyrinic acid a,c-diamide synthase activity
L083_5179	COG1070	Carbohydrate kinase
L083_5180	COG1819	glycosyl
L083_5183	COG5001	Diguanylate cyclase
L083_5185	COG0708	Exodeoxyribonuclease III
L083_5192	COG1643	Atp-dependent helicase
L083_5194	COG4251	negative regulation of phosphorylation
L083_5195	COG1705	Flagellar rod assembly protein muramidase FlgJ
L083_5195	COG3951	Flagellar rod assembly protein muramidase FlgJ
L083_5202	COG3467	pyridoxamine 5'-phosphate
L083_5208	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L083_5210	COG3629	intracellular signal transduction
L083_5210	COG3903	Transcriptional regulator
L083_5211	COG3591	Belongs to the peptidase S1B family
L083_5211	COG1864	DNA RNA non-specific endonuclease
L083_5212	COG2022	thiamine diphosphate biosynthetic process
L083_5224	COG2197	response regulator
L083_5225	COG2183	response to ionizing radiation
L083_5229	COG2409	Drug exporters of the RND superfamily
L083_5231	COG2197	response regulator
L083_5251	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_5258	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L083_5260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L083_5262	COG0584	glycerophosphoryl diester phosphodiesterase
L083_5268	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L083_5270	COG1960	acyl-CoA dehydrogenase activity
L083_5273	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L083_5274	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L083_5276	COG1414	Transcriptional regulator
L083_5277	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L083_5288	COG3480	Lon protease (S16) C-terminal proteolytic domain
L083_5293	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L083_5294	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_5297	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L083_5299	COG0438	transferase activity, transferring glycosyl groups
L083_5305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_5308	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L083_5309	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_5311	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_5313	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_5321	COG4213	ABC transporter substrate-binding protein
L083_5322	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_5324	COG2409	Drug exporters of the RND superfamily
L083_5327	COG1132	(ABC) transporter
L083_5336	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L083_5337	COG0366	Alpha amylase catalytic
L083_5339	COG0277	FAD linked oxidase domain protein
L083_5341	COG0183	Belongs to the thiolase family
L083_5344	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L083_5346	COG0477	Major facilitator Superfamily
L083_5356	COG0789	Transcriptional regulator
L083_5363	COG0667	Aldo Keto reductase
L083_5370	COG0730	response to heat
L083_5374	COG1028	Short-chain dehydrogenase reductase Sdr
L083_5375	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L083_5377	COG1830	Aldolase
L083_5378	COG1465	3-dehydroquinate synthase
L083_5382	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_5386	COG0494	nUDIX hydrolase
L083_5387	COG5297	Belongs to the glycosyl hydrolase family 6
L083_5407	COG0531	amino acid
L083_5428	COG1960	acyl-CoA dehydrogenase activity
L083_5437	COG0028	Belongs to the TPP enzyme family
L083_5440	COG1573	uracil-dna glycosylase
L083_5446	COG1309	transcriptional regulator
L083_5450	COG0738	Major facilitator superfamily
L083_5458	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L083_5459	COG0477	Major facilitator Superfamily
L083_5462	COG1131	(ABC) transporter
L083_5467	COG3511	phospholipase C
L083_5472	COG0640	Transcriptional regulator
L083_5473	COG0247	lactate metabolic process
L083_5473	COG0277	FAD linked oxidase domain protein
L083_5474	COG1802	Transcriptional regulator
L083_5476	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_5484	COG0515	serine threonine protein kinase
L083_5488	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L083_5495	COG2814	Major facilitator Superfamily
L083_5496	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L083_5498	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_5508	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_5511	COG0778	Nitroreductase
L083_5519	COG1024	Enoyl-CoA hydratase
L083_5519	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_5520	COG0640	Transcriptional regulator
L083_5524	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_5526	COG1940	carbohydrate kinase activity
L083_5535	COG0024	Methionine aminopeptidase
L083_5541	COG3903	Transcriptional regulator
L083_5541	COG3629	intracellular signal transduction
L083_5544	COG1595	DNA-templated transcription, initiation
L083_5548	COG1136	(ABC) transporter
L083_5561	COG2197	response regulator
L083_5561	COG3903	Transcriptional regulator
L083_5563	COG0473	3-isopropylmalate dehydrogenase activity
L083_5564	COG0436	Aminotransferase
L083_5565	COG0066	3-isopropylmalate dehydratase activity
L083_5566	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L083_5567	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L083_5570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L083_5571	COG2192	nodulation
L083_5576	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L083_5578	COG4677	pectinesterase activity
L083_5582	COG0395	ABC-type sugar transport system, permease component
L083_5588	COG1175	transmembrane transport
L083_5589	COG1653	transport
L083_5596	COG2755	lipolytic protein G-D-S-L family
L083_5606	COG3507	Belongs to the glycosyl hydrolase 43 family
L083_5607	COG3693	PFAM glycoside hydrolase, family 10
L083_5612	COG0515	serine threonine protein kinase
L083_5612	COG2815	serine threonine protein kinase
L083_5615	COG3485	protocatechuate 3,4-dioxygenase
L083_5618	COG1454	alcohol dehydrogenase
L083_5619	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L083_5622	COG1510	regulation of RNA biosynthetic process
L083_5623	COG1131	(ABC) transporter
L083_5626	COG5297	Belongs to the glycosyl hydrolase family 6
L083_5627	COG3866	Pectate lyase
L083_5634	COG1846	Transcriptional regulator
L083_5635	COG2409	Drug exporters of the RND superfamily
L083_5646	COG2274	protein secretion by the type I secretion system
L083_5647	COG2124	cytochrome p450
L083_5648	COG0017	Asparaginyl-tRNA synthetase
L083_5652	COG1619	proteins homologs of microcin C7 resistance protein MccF
L083_5654	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L083_5657	COG3629	intracellular signal transduction
L083_5657	COG3903	Transcriptional regulator
L083_5660	COG1672	PFAM Archaeal ATPase
L083_5660	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L083_5662	COG4412	M6 family metalloprotease domain protein
L083_5662	COG1404	Belongs to the peptidase S8 family
L083_5663	COG3618	amidohydrolase
L083_5667	COG1129	ABC transporter
L083_5668	COG1172	Belongs to the binding-protein-dependent transport system permease family
L083_5669	COG4948	Mandelate Racemase Muconate Lactonizing
L083_5670	COG2186	Transcriptional regulator
L083_5671	COG2186	Transcriptional regulator
L083_5676	COG0395	ABC-type sugar transport system, permease component
L083_5679	COG1063	alcohol dehydrogenase
L083_5680	COG1028	Short-chain dehydrogenase reductase Sdr
L083_5681	COG0800	Aldolase
L083_5688	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L083_5693	COG2072	flavoprotein involved in K transport
L083_5695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_5696	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L083_5697	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L083_5702	COG0546	phosphoglycolate phosphatase activity
L083_5705	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L083_5709	COG1960	acyl-CoA dehydrogenase activity
L083_5710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L083_5714	COG1063	alcohol dehydrogenase
L083_5718	COG2124	cytochrome p450
L083_5723	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_5724	COG2890	protein-(glutamine-N5) methyltransferase activity
L083_5725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_5729	COG0798	PFAM Bile acid sodium symporter
L083_5730	COG3850	Histidine kinase
L083_5730	COG5002	protein histidine kinase activity
L083_5734	COG0745	RESPONSE REGULATOR receiver
L083_5735	COG5002	protein histidine kinase activity
L083_5736	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L083_5736	COG2755	lipolytic protein G-D-S-L family
L083_5745	COG4249	Peptidase C14 caspase catalytic subunit p20
L083_5745	COG2319	Wd-40 repeat
L083_5762	COG1160	GTP binding
L083_5763	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L083_5765	COG1187	pseudouridine synthase activity
L083_5766	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L083_5782	COG4221	oxidoreductase activity
L083_5788	COG4221	oxidoreductase activity
L083_5789	COG0583	DNA-binding transcription factor activity
L083_5793	COG1752	Esterase of the alpha-beta hydrolase superfamily
L083_5797	COG1752	Esterase of the alpha-beta hydrolase superfamily
L083_5808	COG0504	CTP synthase activity
L083_5811	COG0297	glycogen (starch) synthase activity
L083_5817	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L083_5822	COG0647	UMP catabolic process
L083_5826	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L083_5827	COG2326	polyphosphate kinase activity
L083_5830	COG0563	adenylate kinase activity
L083_5839	COG2094	Belongs to the DNA glycosylase MPG family
L083_5844	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_5847	COG1733	regulation of RNA biosynthetic process
L083_5853	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L083_5854	COG0406	alpha-ribazole phosphatase activity
L083_5857	COG1175	transmembrane transport
L083_5858	COG0395	ABC-type sugar transport system, permease component
L083_5860	COG0583	DNA-binding transcription factor activity
L083_5861	COG0730	response to heat
L083_5865	COG0165	Argininosuccinate lyase
L083_5866	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L083_5867	COG0137	argininosuccinate synthase activity
L083_5869	COG1438	arginine binding
L083_5871	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_5872	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L083_5873	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L083_5874	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L083_5878	COG2949	membrane
L083_5888	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
L083_5889	COG2318	DinB family
L083_5893	COG1028	Short-chain dehydrogenase reductase Sdr
L083_5894	COG0072	phenylalanine-tRNA ligase activity
L083_5894	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L083_5895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L083_5896	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L083_5897	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L083_5898	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L083_5899	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L083_5901	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L083_5902	COG0140	phosphoribosyl-ATP diphosphatase activity
L083_5905	COG0765	amino acid transport
L083_5907	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L083_5908	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_5908	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L083_5911	COG0745	RESPONSE REGULATOR receiver
L083_5915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L083_5916	COG0242	peptide deformylase activity
L083_5919	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L083_5920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_5922	COG1758	RNA polymerase activity
L083_5923	COG0194	GDP metabolic process
L083_5924	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L083_5925	COG0284	orotidine-5'-phosphate decarboxylase activity
L083_5927	COG0167	dihydroorotate dehydrogenase activity
L083_5929	COG0505	Belongs to the CarA family
L083_5930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_5931	COG0540	Belongs to the ATCase OTCase family
L083_5932	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L083_5934	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L083_5935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L083_5936	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L083_5937	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L083_5938	COG0542	response to heat
L083_5939	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L083_5940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L083_5943	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L083_5944	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L083_5945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L083_5946	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L083_5959	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L083_5962	COG0477	Major facilitator Superfamily
L083_5996	COG0740	serine-type endopeptidase activity
L083_6032	COG1595	DNA-templated transcription, initiation
L083_6035	COG3964	amidohydrolase
L083_6036	COG0251	oxidation-reduction process
L083_6037	COG3415	Transposase
L083_6037	COG2801	Transposase and inactivated derivatives
L083_6039	COG0831	urea catabolic process
L083_6040	COG0832	Belongs to the urease beta subunit family
L083_6041	COG0804	urea catabolic process
L083_6043	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L083_6044	COG0829	nickel cation binding
L083_6045	COG1191	sigma factor activity
L083_6048	COG0515	serine threonine protein kinase
L083_6051	COG2814	Major facilitator Superfamily
L083_6055	COG0124	histidyl-tRNA synthetase
L083_6058	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L083_6061	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L083_6062	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L083_6066	COG2255	four-way junction helicase activity
L083_6067	COG0632	four-way junction helicase activity
L083_6068	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L083_6070	COG0217	transcriptional regulatory protein
L083_6071	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L083_6072	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L083_6074	COG0438	transferase activity, transferring glycosyl groups
L083_6075	COG1560	Kdo2-lipid A biosynthetic process
L083_6079	COG1595	DNA-templated transcription, initiation
L083_6087	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L083_6089	COG0667	Aldo Keto reductase
L083_6091	COG1278	Cold shock
L083_6099	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_6102	COG0514	ATP-dependent DNA helicase (RecQ)
L083_6107	COG2084	Dehydrogenase
L083_6109	COG3850	Histidine kinase
L083_6114	COG1028	Short-chain dehydrogenase reductase Sdr
L083_6125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_6138	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_6142	COG2197	response regulator
L083_6147	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L083_6150	COG4266	Belongs to the allantoicase family
L083_6151	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L083_6159	COG1643	Atp-dependent helicase
L083_6180	COG0840	transmembrane signaling receptor activity
L083_6181	COG2382	esterase
L083_6182	COG2226	methyltransferase
L083_6184	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L083_6192	COG0405	Gamma-glutamyltransferase
L083_6194	COG1132	(ABC) transporter
L083_6200	COG2936	dipeptidyl-peptidase activity
L083_6201	COG1082	Xylose isomerase domain protein TIM barrel
L083_6203	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_6204	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_6205	COG1216	Glycosyl transferase, family 2
L083_6206	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_6211	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_6214	COG1686	Belongs to the peptidase S11 family
L083_6217	COG1191	sigma factor activity
L083_6218	COG3973	AAA domain
L083_6219	COG1191	sigma factor activity
L083_6220	COG0513	Belongs to the DEAD box helicase family
L083_6226	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L083_6227	COG1609	Transcriptional regulator
L083_6230	COG0601	transmembrane transport
L083_6231	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L083_6232	COG0444	Belongs to the ABC transporter superfamily
L083_6233	COG2723	6-phospho-beta-galactosidase activity
L083_6236	COG1940	carbohydrate kinase activity
L083_6238	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L083_6240	COG1028	Short-chain dehydrogenase reductase Sdr
L083_6240	COG3347	Dehydrogenase
L083_6242	COG1595	DNA-templated transcription, initiation
L083_6244	COG0154	amidase activity
L083_6245	COG4733	cellulase activity
L083_6245	COG5297	Belongs to the glycosyl hydrolase family 6
L083_6253	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L083_6254	COG0187	DNA topoisomerase II activity
L083_6257	COG2197	response regulator
L083_6260	COG2205	protein histidine kinase activity
L083_6261	COG0745	RESPONSE REGULATOR receiver
L083_6270	COG0387	Pfam Sodium calcium exchanger
L083_6271	COG0435	Glutathione S-transferase
L083_6274	COG0714	Associated with various cellular activities
L083_6276	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L083_6284	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L083_6291	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L083_6292	COG0543	2 iron, 2 sulfur cluster binding
L083_6292	COG0633	Ferredoxin
L083_6299	COG1794	racemase activity, acting on amino acids and derivatives
L083_6300	COG3191	aminopeptidase activity
L083_6301	COG4565	transcriptional regulatory protein
L083_6302	COG3290	protein histidine kinase activity
L083_6304	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_6305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L083_6308	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L083_6310	COG0515	serine threonine protein kinase
L083_6312	COG1396	sequence-specific DNA binding
L083_6319	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L083_6320	COG1136	(ABC) transporter
L083_6322	COG4181	ATPase activity
L083_6326	COG0598	Magnesium transport protein CorA
L083_6327	COG0300	oxidoreductase activity
L083_6328	COG1595	DNA-templated transcription, initiation
L083_6331	COG3119	arylsulfatase activity
L083_6332	COG1619	proteins homologs of microcin C7 resistance protein MccF
L083_6337	COG0246	Mannitol dehydrogenase
L083_6339	COG1904	glucuronate isomerase
L083_6341	COG0395	ABC-type sugar transport system, permease component
L083_6344	COG0673	inositol 2-dehydrogenase activity
L083_6346	COG1609	Transcriptional regulator
L083_6347	COG1606	tRNA processing
L083_6348	COG1691	(AIR) carboxylase
L083_6349	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
L083_6351	COG4585	Histidine kinase
L083_6365	COG0745	RESPONSE REGULATOR receiver
L083_6365	COG3706	GGDEF domain
L083_6368	COG0671	phosphoesterase, PA-phosphatase related
L083_6370	COG1803	Methylglyoxal synthase
L083_6370	COG1597	lipid kinase activity
L083_6371	COG4762	Protein conserved in bacteria
L083_6380	COG0477	Major facilitator Superfamily
L083_6384	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L083_6387	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L083_6390	COG0746	molybdenum cofactor guanylyltransferase activity
L083_6393	COG1028	Short-chain dehydrogenase reductase Sdr
L083_6397	COG0800	Aldolase
L083_6404	COG0438	transferase activity, transferring glycosyl groups
L083_6405	COG0438	transferase activity, transferring glycosyl groups
L083_6408	COG2226	methyltransferase
L083_6409	COG0673	inositol 2-dehydrogenase activity
L083_6410	COG0702	epimerase
L083_6414	COG3012	SEC-C Motif Domain Protein
L083_6415	COG0789	Transcriptional regulator
L083_6416	COG0840	transmembrane signaling receptor activity
L083_6417	COG1609	Transcriptional regulator
L083_6418	COG1653	transport
L083_6419	COG1175	transmembrane transport
L083_6421	COG0366	Alpha amylase catalytic
L083_6424	COG1595	DNA-templated transcription, initiation
L083_6427	COG0659	secondary active sulfate transmembrane transporter activity
L083_6429	COG2308	Evidence 4 Homologs of previously reported genes of
L083_6429	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_6430	COG0367	asparagine synthase
L083_6431	COG1506	peptidase
L083_6440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L083_6442	COG2814	Major facilitator Superfamily
L083_6448	COG0725	ABC transporter, periplasmic molybdate-binding protein
L083_6455	COG1136	(ABC) transporter
L083_6466	COG0500	methyltransferase
L083_6473	COG1215	transferase activity, transferring glycosyl groups
L083_6480	COG1131	(ABC) transporter
L083_6483	COG0328	RNA-DNA hybrid ribonuclease activity
L083_6490	COG0010	Belongs to the arginase family
L083_6491	COG4585	Histidine kinase
L083_6493	COG2197	response regulator
L083_6494	COG3537	Alpha-1,2-mannosidase
L083_6495	COG3467	pyridoxamine 5'-phosphate
L083_6498	COG1653	transport
L083_6499	COG1175	transmembrane transport
L083_6500	COG0395	ABC-type sugar transport system, permease component
L083_6501	COG1609	Transcriptional regulator
L083_6505	COG3537	Alpha-1,2-mannosidase
L083_6517	COG0702	epimerase
L083_6528	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L083_6541	COG0823	Involved in the tonB-independent uptake of proteins
L083_6542	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L083_6544	COG1477	protein flavinylation
L083_6546	COG2226	methyltransferase
L083_6551	COG0640	Transcriptional regulator
L083_6555	COG3706	GGDEF domain
L083_6560	COG2409	Drug exporters of the RND superfamily
L083_6565	COG5001	Diguanylate cyclase
L083_6574	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L083_6575	COG1028	Short-chain dehydrogenase reductase Sdr
L083_6576	COG2197	response regulator
L083_6580	COG0395	ABC-type sugar transport system, permease component
L083_6581	COG1175	transmembrane transport
L083_6583	COG4821	SIS domain
L083_6584	COG1737	Transcriptional regulator
L083_6589	COG1063	alcohol dehydrogenase
L083_6590	COG1473	amidohydrolase
L083_6591	COG2197	response regulator
L083_6592	COG0318	PFAM AMP-dependent synthetase and ligase
L083_6598	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L083_6599	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L083_6600	COG2080	2 iron, 2 sulfur cluster binding
L083_6606	COG1984	allophanate hydrolase subunit 2
L083_6607	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L083_6608	COG4336	lyase activity
L083_6609	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L083_6610	COG1914	H( )-stimulated, divalent metal cation uptake system
L083_6611	COG2264	protein methyltransferase activity
L083_6624	COG0419	ATPase involved in DNA repair
L083_6625	COG0420	3'-5' exonuclease activity
L083_6632	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L083_6633	COG1253	flavin adenine dinucleotide binding
L083_6642	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L083_6647	COG1309	transcriptional regulator
L083_6648	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L083_6652	COG1028	Short-chain dehydrogenase reductase Sdr
L083_6653	COG1793	dna ligase
L083_6663	COG1028	Short-chain dehydrogenase reductase Sdr
L083_6666	COG0655	NAD(P)H dehydrogenase (quinone) activity
L083_6669	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L083_6670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L083_6673	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_6674	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
L083_6675	COG0183	Belongs to the thiolase family
L083_6676	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_6676	COG1024	Enoyl-CoA hydratase
L083_6679	COG2205	protein histidine kinase activity
L083_6680	COG0745	RESPONSE REGULATOR receiver
L083_6684	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L083_6685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L083_6686	COG0531	amino acid
L083_6687	COG0569	domain protein
L083_6693	COG0756	dUTP diphosphatase activity
L083_6697	COG0483	inositol monophosphate 1-phosphatase activity
L083_6702	COG2860	membrane
L083_6704	COG2313	pseudouridylate synthase activity
L083_6712	COG1490	D-aminoacyl-tRNA deacylase activity
L083_6717	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L083_6718	COG0123	including yeast histone deacetylase and acetoin utilization protein
L083_6726	COG0738	Major facilitator superfamily
L083_6729	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L083_6737	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L083_6739	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L083_6740	COG1196	nuclear chromosome segregation
L083_6742	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L083_6743	COG0640	Transcriptional regulator
L083_6745	COG1733	regulation of RNA biosynthetic process
L083_6747	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L083_6749	COG1126	abc transporter atp-binding protein
L083_6750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_6751	COG0765	amino acid transport
L083_6752	COG0765	amino acid transport
L083_6753	COG1418	mRNA catabolic process
L083_6758	COG2137	regulation of response to DNA damage stimulus
L083_6759	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L083_6761	COG1573	uracil-dna glycosylase
L083_6765	COG4326	sporulation control protein
L083_6766	COG1253	flavin adenine dinucleotide binding
L083_6768	COG2815	serine threonine protein kinase
L083_6768	COG0515	serine threonine protein kinase
L083_6771	COG1201	RNA secondary structure unwinding
L083_6774	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_6779	COG1396	sequence-specific DNA binding
L083_6780	COG1058	Belongs to the CinA family
L083_6780	COG1546	Belongs to the CinA family
L083_6782	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L083_6784	COG1674	ftsk spoiiie
L083_6787	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L083_6788	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L083_6790	COG3214	Protein conserved in bacteria
L083_6792	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L083_6794	COG0612	Peptidase, M16
L083_6795	COG1185	polyribonucleotide nucleotidyltransferase activity
L083_6797	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L083_6799	COG2205	protein histidine kinase activity
L083_6799	COG0784	Response regulator, receiver
L083_6799	COG5002	protein histidine kinase activity
L083_6800	COG0745	RESPONSE REGULATOR receiver
L083_6801	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L083_6805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L083_6808	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L083_6811	COG0195	Participates in both transcription termination and antitermination
L083_6813	COG0779	Required for maturation of 30S ribosomal subunits
L083_6820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L083_6821	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L083_6823	COG1012	belongs to the aldehyde dehydrogenase family
L083_6830	COG4152	abc transporter atp-binding protein
L083_6831	COG1668	transmembrane transport
L083_6832	COG1309	transcriptional regulator
L083_6833	COG1511	domain protein
L083_6834	COG1121	(ABC) transporter
L083_6839	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L083_6845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L083_6845	COG2146	nitrite reductase [NAD(P)H] activity
L083_6848	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L083_6850	COG0233	cytoplasmic translational termination
L083_6851	COG0528	UMP kinase activity
L083_6852	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L083_6853	COG0052	Belongs to the universal ribosomal protein uS2 family
L083_6855	COG0792	nuclease activity
L083_6856	COG0606	chelatase, subunit chli
L083_6866	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L083_6868	COG0681	Belongs to the peptidase S26 family
L083_6869	COG0681	Belongs to the peptidase S26 family
L083_6870	COG0335	large ribosomal subunit rRNA binding
L083_6871	COG0336	Belongs to the RNA methyltransferase TrmD family
L083_6872	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L083_6873	COG1837	Belongs to the UPF0109 family
L083_6874	COG0228	four-way junction DNA binding
L083_6883	COG0438	transferase activity, transferring glycosyl groups
L083_6885	COG2755	lipolytic protein G-D-S-L family
L083_6885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L083_6888	COG0463	Glycosyl transferase, family 2
L083_6889	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L083_6898	COG2318	DinB family
L083_6903	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_6905	COG0571	ribonuclease III activity
L083_6906	COG0416	fatty acid biosynthetic process
L083_6907	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L083_6910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L083_6911	COG0742	ribosomal rna small subunit methyltransferase
L083_6916	COG1461	Dihydroxyacetone kinase
L083_6917	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L083_6924	COG1131	(ABC) transporter
L083_6927	COG0626	cystathionine gamma-synthase activity
L083_6928	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L083_6932	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L083_6935	COG0776	regulation of translation
L083_6936	COG0066	3-isopropylmalate dehydratase activity
L083_6943	COG1476	TRANSCRIPTIONal
L083_6945	COG1131	(ABC) transporter
L083_6948	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L083_6949	COG2205	protein histidine kinase activity
L083_6950	COG0745	RESPONSE REGULATOR receiver
L083_6951	COG0612	Peptidase, M16
L083_6954	COG0583	DNA-binding transcription factor activity
L083_6958	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L083_6960	COG1864	DNA RNA non-specific endonuclease
L083_6960	COG3591	Belongs to the peptidase S1B family
L083_6961	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L083_6962	COG0473	3-isopropylmalate dehydrogenase activity
L083_6964	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L083_6967	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L083_6968	COG0440	acetolactate synthase activity
L083_6970	COG0129	dihydroxy-acid dehydratase activity
L083_6971	COG3300	MHYT domain
L083_6971	COG5001	Diguanylate cyclase
L083_6975	COG0784	Response regulator, receiver
L083_6976	COG4251	negative regulation of phosphorylation
L083_6978	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L083_6980	COG3833	ABC-type maltose transport systems, permease component
L083_6981	COG1175	transmembrane transport
L083_6983	COG1609	Transcriptional regulator
L083_6992	COG2133	pyrroloquinoline quinone binding
L083_6995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L083_6996	COG0154	amidase activity
L083_6997	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L083_6999	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L083_7001	COG0482	sulfurtransferase activity
L083_7003	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L083_7006	COG2149	membrane
L083_7010	COG0443	Heat shock 70 kDa protein
L083_7015	COG0840	transmembrane signaling receptor activity
L083_7016	COG0840	transmembrane signaling receptor activity
L083_7017	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L083_7018	COG1119	ATPase activity
L083_7020	COG1472	Belongs to the glycosyl hydrolase 3 family
L083_7026	COG2902	Dehydrogenase
L083_7028	COG0010	Belongs to the arginase family
L083_7034	COG1703	isobutyryl-CoA mutase activity
L083_7035	COG0183	Belongs to the thiolase family
L083_7047	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
L083_7050	COG1674	ftsk spoiiie
L083_7052	COG1250	3-hydroxyacyl-CoA dehydrogenase
L083_7059	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L083_7061	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L083_7062	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L083_7063	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L083_7064	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L083_7065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L083_7066	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L083_7067	COG0356	it plays a direct role in the translocation of protons across the membrane
L083_7070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L083_7071	COG0702	epimerase
L083_7074	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L083_7075	COG2890	protein-(glutamine-N5) methyltransferase activity
L083_7076	COG3706	GGDEF domain
L083_7079	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L083_7080	COG0254	rRNA binding
L083_7085	COG0083	homoserine kinase activity
L083_7087	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L083_7088	COG1846	Transcriptional regulator
L083_7090	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L083_7091	COG0460	homoserine dehydrogenase
L083_7092	COG0019	diaminopimelate decarboxylase activity
L083_7093	COG0018	arginyl-trna synthetase
L083_7099	COG1120	ATPase activity
L083_7100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_7101	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L083_7102	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L083_7103	COG2815	serine threonine protein kinase
L083_7103	COG0515	serine threonine protein kinase
L083_7107	COG2986	histidine ammonia-lyase
L083_7111	COG0475	glutathione-regulated potassium exporter activity
L083_7112	COG0745	RESPONSE REGULATOR receiver
L083_7119	COG4977	sequence-specific DNA binding
L083_7123	COG1309	transcriptional regulator
L083_7125	COG1742	UPF0060 membrane protein
L083_7135	COG1595	DNA-templated transcription, initiation
L083_7136	COG0673	inositol 2-dehydrogenase activity
L083_7142	COG2814	Major facilitator Superfamily
L083_7146	COG2226	methyltransferase
L083_7149	COG1028	Short-chain dehydrogenase reductase Sdr
L083_7150	COG0318	PFAM AMP-dependent synthetase and ligase
L083_7151	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L083_7153	COG2197	response regulator
L083_7154	COG3629	intracellular signal transduction
L083_7157	COG0477	Major facilitator Superfamily
L083_7159	COG0754	glutathionylspermidine amidase activity
L083_7162	COG0366	Alpha amylase catalytic
L083_7165	COG0586	Pfam SNARE associated Golgi protein
L083_7167	COG3469	chitinase activity
L083_7170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_7171	COG0446	pyridine nucleotide-disulphide oxidoreductase
L083_7173	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_7178	COG1834	amidinotransferase
L083_7179	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L083_7181	COG0740	serine-type endopeptidase activity
L083_7185	COG3842	ATPase activity
L083_7187	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_7188	COG2205	protein histidine kinase activity
L083_7189	COG0745	RESPONSE REGULATOR receiver
L083_7192	COG1131	(ABC) transporter
L083_7194	COG0508	dehydrogenase complex catalyzes the overall conversion of
L083_7194	COG0567	Dehydrogenase, E1 component
L083_7197	COG4221	oxidoreductase activity
L083_7198	COG0857	belongs to the CobB CobQ family
L083_7198	COG0280	phosphate acetyltransferase
L083_7199	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L083_7201	COG1064	alcohol dehydrogenase
L083_7206	COG2172	sigma factor antagonist activity
L083_7207	COG2188	Transcriptional regulator
L083_7209	COG1597	lipid kinase activity
L083_7213	COG0175	sulfate reduction
L083_7219	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_7221	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L083_7223	COG1595	DNA-templated transcription, initiation
L083_7226	COG2135	peptidase activity
L083_7227	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L083_7228	COG1162	GTPase activity
L083_7229	COG0483	inositol monophosphate 1-phosphatase activity
L083_7233	COG2197	response regulator
L083_7247	COG0861	Integral membrane protein TerC family
L083_7248	COG1357	PFAM Pentapeptide repeats (8 copies)
L083_7253	COG1615	UPF0182 protein
L083_7254	COG3480	Lon protease (S16) C-terminal proteolytic domain
L083_7261	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L083_7267	COG2816	NAD+ diphosphatase activity
L083_7270	COG1959	2 iron, 2 sulfur cluster binding
L083_7272	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L083_7273	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L083_7277	COG1278	Cold shock
L083_7281	COG1609	Transcriptional regulator
L083_7282	COG2171	N-acyltransferase activity
L083_7285	COG1611	Belongs to the LOG family
L083_7286	COG1611	Belongs to the LOG family
L083_7292	COG0789	Transcriptional regulator
L083_7295	COG2226	methyltransferase
L083_7298	COG3287	FIST C domain
L083_7298	COG2200	EAL domain
L083_7298	COG2199	diguanylate cyclase activity
L083_7300	COG0438	transferase activity, transferring glycosyl groups
L083_7318	COG1215	transferase activity, transferring glycosyl groups
L083_7321	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L083_7323	COG0463	Glycosyl transferase, family 2
L083_7324	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L083_7330	COG0297	glycogen (starch) synthase activity
L083_7332	COG0297	glycogen (starch) synthase activity
L083_7340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L083_7348	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_7354	COG0656	L-ascorbic acid biosynthetic process
L083_7361	COG1404	Belongs to the peptidase S8 family
L083_7366	COG0456	acetyltransferase
L083_7369	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L083_7373	COG3706	GGDEF domain
L083_7374	COG0312	modulator of DNA gyrase
L083_7378	COG1053	succinate dehydrogenase
L083_7387	COG0410	ABC transporter
L083_7394	COG1960	acyl-CoA dehydrogenase activity
L083_7396	COG0039	L-malate dehydrogenase activity
L083_7397	COG0121	glutamine amidotransferase
L083_7398	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L083_7399	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L083_7404	COG1960	acyl-CoA dehydrogenase activity
L083_7405	COG0318	PFAM AMP-dependent synthetase and ligase
L083_7414	COG0431	NADPH-dependent FMN reductase
L083_7437	COG0012	GTP binding
L083_7440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L083_7442	COG0525	valine-tRNA ligase activity
L083_7449	COG1722	exodeoxyribonuclease VII activity
L083_7450	COG1570	exodeoxyribonuclease VII activity
L083_7453	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L083_7455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L083_7462	COG1322	Protein conserved in bacteria
L083_7465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L083_7466	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L083_7466	COG0561	phosphatase activity
L083_7468	COG0644	oxidoreductase
L083_7470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L083_7476	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L083_7478	COG0424	maF-like protein
L083_7482	COG2815	serine threonine protein kinase
L083_7482	COG0515	serine threonine protein kinase
L083_7486	COG4770	biotin carboxylase activity
L083_7495	COG1473	amidohydrolase
L083_7495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L083_7496	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_7496	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L083_7498	COG0515	serine threonine protein kinase
L083_7499	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L083_7502	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L083_7503	COG1051	belongs to the nudix hydrolase family
L083_7504	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L083_7505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L083_7506	COG1012	belongs to the aldehyde dehydrogenase family
L083_7507	COG1012	belongs to the aldehyde dehydrogenase family
L083_7515	COG2018	Roadblock/LC7 domain
L083_7519	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L083_7527	COG1744	ABC transporter substrate-binding protein PnrA-like
L083_7530	COG1309	transcriptional regulator
L083_7534	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L083_7535	COG0180	Tryptophanyl-tRNA synthetase
L083_7536	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L083_7540	COG1218	3'(2'),5'-bisphosphate nucleotidase
L083_7542	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L083_7543	COG0193	aminoacyl-tRNA hydrolase activity
L083_7544	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L083_7546	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L083_7554	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L083_7557	COG1309	transcriptional regulator
L083_7560	COG0488	(ABC) transporter
L083_7561	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L083_7563	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L083_7565	COG0084	hydrolase, TatD family'
L083_7571	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L083_7576	COG1215	transferase activity, transferring glycosyl groups
L083_7579	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L083_7585	COG0303	'Molybdopterin
L083_7586	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L083_7587	COG0745	RESPONSE REGULATOR receiver
L083_7587	COG3706	GGDEF domain
L083_7588	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L083_7598	COG3415	Transposase
L083_7598	COG2801	Transposase and inactivated derivatives
L083_7599	COG2095	MarC family integral membrane protein
L083_7600	COG0613	PHP domain protein
L083_7606	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L083_7608	COG1832	CoA-binding protein
L083_7610	COG1028	Short-chain dehydrogenase reductase Sdr
L083_7616	COG0384	phenazine biosynthesis protein PhzF
L083_7617	COG2239	Acts as a magnesium transporter
L083_7621	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L083_7622	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L083_7623	COG4122	O-methyltransferase activity
L083_7624	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L083_7627	COG1024	Enoyl-CoA hydratase
L083_7630	COG0519	Catalyzes the synthesis of GMP from XMP
L083_7633	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L083_7634	COG0674	pyruvate-flavodoxin oxidoreductase activity
L083_7634	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L083_7635	COG1013	pyruvate-flavodoxin oxidoreductase activity
L083_7636	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L083_7644	COG0113	porphobilinogen synthase activity
L083_7645	COG1648	precorrin-2 dehydrogenase activity
L083_7645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L083_7646	COG0181	hydroxymethylbilane synthase activity
L083_7647	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L083_7648	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L083_7651	COG0318	PFAM AMP-dependent synthetase and ligase
L083_7652	COG1595	DNA-templated transcription, initiation
L083_7658	COG0506	proline dehydrogenase activity
L083_7659	COG1082	Xylose isomerase domain protein TIM barrel
L083_7665	COG0588	phosphoglycerate mutase activity
L083_7667	COG0835	chemotaxis
L083_7672	COG0438	transferase activity, transferring glycosyl groups
L083_7679	COG2205	protein histidine kinase activity
L083_7683	COG0741	lytic transglycosylase activity
L083_7683	COG0739	heme binding
L083_7683	COG1196	nuclear chromosome segregation
L083_7684	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L083_7685	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
L083_7687	COG4786	Flagellar basal body rod
L083_7687	COG1256	bacterial-type flagellum assembly
L083_7689	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L083_7691	COG1516	flagellar protein fliS
L083_7693	COG1815	bacterial-type flagellum-dependent cell motility
L083_7694	COG1558	bacterial-type flagellum-dependent cell motility
L083_7695	COG1677	Flagellar hook-basal body complex protein FliE
L083_7696	COG1766	The M ring may be actively involved in energy transduction
L083_7697	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L083_7699	COG1157	protein secretion by the type III secretion system
L083_7701	COG0483	inositol monophosphate 1-phosphatase activity
L083_7702	COG0583	DNA-binding transcription factor activity
L083_7704	COG0741	lytic transglycosylase activity
L083_7704	COG1196	nuclear chromosome segregation
L083_7704	COG0739	heme binding
L083_7706	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L083_7709	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L083_7712	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L083_7713	COG1776	CheC inhibitor of MCP methylation
L083_7713	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L083_7715	COG1338	Plays a role in the flagellum-specific transport system
L083_7717	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L083_7718	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L083_7723	COG0745	RESPONSE REGULATOR receiver
L083_7727	COG2201	protein-glutamate methylesterase activity
L083_7729	COG0835	chemotaxis
L083_7730	COG2198	Histidine kinase
L083_7730	COG0643	Histidine kinase
L083_7731	COG0745	RESPONSE REGULATOR receiver
L083_7732	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L083_7732	COG0784	Response regulator, receiver
L083_7732	COG2205	protein histidine kinase activity
L083_7732	COG2198	Histidine kinase
L083_7734	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L083_7745	COG3246	L-lysine catabolic process to acetate
L083_7747	COG0735	belongs to the Fur family
L083_7748	COG4044	May play a role in the intracellular transport of hydrophobic ligands
L083_7755	COG0745	RESPONSE REGULATOR receiver
L083_7756	COG0456	acetyltransferase
L083_7757	COG3483	tryptophan 2,3-dioxygenase activity
L083_7758	COG1522	sequence-specific DNA binding
L083_7759	COG2814	Major facilitator Superfamily
L083_7763	COG0581	inorganic phosphate transmembrane transporter activity
L083_7764	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L083_7765	COG0673	inositol 2-dehydrogenase activity
L083_7769	COG0306	phosphate transporter
L083_7777	COG2339	peptidase activity
L083_7784	COG0459	protein refolding
L083_7786	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L083_7787	COG0456	acetyltransferase
L083_7789	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L083_7790	COG1131	(ABC) transporter
L083_7793	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_7795	COG1131	(ABC) transporter
L083_7797	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
L083_7799	COG1349	DNA-binding transcription factor activity
L083_7800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L083_7803	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L083_7808	COG0114	fumarate hydratase activity
L083_7810	COG0215	cysteine-tRNA ligase activity
L083_7811	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L083_7812	COG0443	Heat shock 70 kDa protein
L083_7813	COG3842	ATPase activity
L083_7814	COG2226	methyltransferase
L083_7818	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L083_7818	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L083_7821	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L083_7824	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L083_7834	COG1846	Transcriptional regulator
L083_7834	COG1940	carbohydrate kinase activity
L083_7836	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L083_7837	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L083_7842	COG1960	acyl-CoA dehydrogenase activity
L083_7843	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L083_7846	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L083_7847	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
L083_7849	COG1194	a g-specific adenine glycosylase
L083_7852	COG0542	response to heat
L083_7855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L083_7857	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L083_7859	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L083_7861	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L083_7863	COG0649	NAD binding
L083_7866	COG1174	glycine betaine transport
L083_7867	COG1174	glycine betaine transport
L083_7868	COG1125	glycine betaine transport
L083_7868	COG0517	IMP dehydrogenase activity
L083_7874	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L083_7875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L083_7881	COG0739	heme binding
L083_7884	COG1674	ftsk spoiiie
L083_7887	COG0302	gtp cyclohydrolase
L083_7888	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L083_7890	COG0037	tRNA processing
L083_7894	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L083_7896	COG1674	ftsk spoiiie
L083_7900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L083_7901	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L083_7902	COG2843	Capsule synthesis protein
L083_7904	COG0825	malonyl-CoA metabolic process
L083_7912	COG0003	Pfam Anion-transporting ATPase
L083_7915	COG1610	YqeY-like protein
L083_7920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L083_7930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L083_7931	COG1324	tolerance protein
L083_7932	COG0789	Transcriptional regulator
L083_7935	COG4608	Belongs to the ABC transporter superfamily
L083_7940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L083_7941	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L083_7945	COG1309	transcriptional regulator
L083_7951	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L083_7953	COG0590	tRNA wobble adenosine to inosine editing
L083_7954	COG0813	purine-nucleoside phosphorylase activity
L083_7969	COG2318	DinB family
L083_7970	COG0287	Prephenate dehydrogenase
L083_7978	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L083_7978	COG1796	DNA polymerase
L083_7982	COG0642	Histidine kinase
L083_7983	COG2018	Roadblock/LC7 domain
L083_7988	COG2255	four-way junction helicase activity
L083_7993	COG1215	transferase activity, transferring glycosyl groups
L083_7994	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L083_8004	COG3706	GGDEF domain
L083_8015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L083_8019	COG0745	RESPONSE REGULATOR receiver
L083_8021	COG2205	protein histidine kinase activity
L083_8036	COG2197	response regulator
L083_8037	COG4585	Histidine kinase
L083_8040	COG0745	RESPONSE REGULATOR receiver
L083_8041	COG5002	protein histidine kinase activity
L083_8043	COG1136	(ABC) transporter
L083_8044	COG0577	efflux transmembrane transporter activity
L083_8044	COG1136	(ABC) transporter
L083_8047	COG0640	Transcriptional regulator
L083_8048	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L083_8057	COG4585	Histidine kinase
L083_8058	COG2197	response regulator
L083_8061	COG4221	oxidoreductase activity
L083_8062	COG0702	epimerase
L083_8064	COG2207	Transcriptional regulator
L083_8068	COG0242	peptide deformylase activity
L083_8072	COG1881	PFAM PEBP family protein
L083_8073	COG5002	protein histidine kinase activity
L083_8077	COG1388	LysM domain
L083_8077	COG0791	NLP P60 protein
L083_8077	COG3103	Sh3 type 3 domain protein
L083_8078	COG0321	lipoyl(octanoyl) transferase activity
L083_8081	COG1028	Short-chain dehydrogenase reductase Sdr
L083_8081	COG3321	synthase
L083_8081	COG0604	alcohol dehydrogenase
L083_8082	COG3469	chitinase activity
L083_8085	COG0371	Dehydrogenase
L083_8089	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L083_8090	COG0598	Magnesium transport protein CorA
L083_8093	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L083_8095	COG0183	Belongs to the thiolase family
L083_8097	COG3958	Transketolase
L083_8098	COG3959	Transketolase, thiamine diphosphate binding domain
L083_8099	COG0789	Transcriptional regulator
L083_8102	COG0438	transferase activity, transferring glycosyl groups
L083_8103	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L083_8104	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L083_8106	COG3275	phosphorelay sensor kinase activity
L083_8109	COG2205	protein histidine kinase activity
L083_8111	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L083_8115	COG0180	Tryptophanyl-tRNA synthetase
L083_8118	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L083_8119	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L083_8120	COG1316	TRANSCRIPTIONal
L083_8121	COG1316	TRANSCRIPTIONal
L083_8124	COG5002	protein histidine kinase activity
L083_8132	COG0789	Transcriptional regulator
L083_8133	COG1064	alcohol dehydrogenase
L083_8136	COG1764	response to oxidative stress
L083_8138	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L083_8139	COG0561	phosphatase activity
L083_8140	COG0561	phosphatase activity
L083_8142	COG1834	amidinotransferase
L083_8143	COG1522	sequence-specific DNA binding
L083_8147	COG0746	molybdenum cofactor guanylyltransferase activity
L083_8148	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L083_8149	COG3540	Alkaline phosphatase
L083_8153	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L083_8155	COG1408	metallophosphoesterase
L083_8157	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L083_8164	COG0315	cyclic pyranopterin monophosphate synthase activity
L083_8164	COG0521	Mo-molybdopterin cofactor biosynthetic process
L083_8165	COG0315	cyclic pyranopterin monophosphate synthase activity
L083_8166	COG3300	MHYT domain
L083_8166	COG5001	Diguanylate cyclase
L083_8175	COG0305	Participates in initiation and elongation during chromosome replication
L083_8178	COG0359	binds to the 23S rRNA
L083_8179	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L083_8181	COG0360	Binds together with S18 to 16S ribosomal RNA
L083_8186	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L083_8191	COG0617	tRNA 3'-terminal CCA addition
L083_8194	COG2815	serine threonine protein kinase
L083_8194	COG0515	serine threonine protein kinase
L083_8195	COG1595	DNA-templated transcription, initiation
L083_8197	COG0492	ferredoxin-NADP+ reductase activity
L083_8198	COG3118	belongs to the thioredoxin family
L083_8199	COG3409	Peptidoglycan-binding domain 1 protein
L083_8199	COG0860	N-Acetylmuramoyl-L-alanine amidase
L083_8200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L083_8202	COG1181	Belongs to the D-alanine--D-alanine ligase family
L083_8206	COG1192	Involved in chromosome partitioning
L083_8207	COG0357	Ribosomal RNA small subunit methyltransferase G
L083_8209	COG0706	membrane insertase activity
L083_8210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L083_8211	COG0594	ribonuclease P activity
L083_8212	COG0230	Belongs to the bacterial ribosomal protein bL34 family