locus-tag	class	description
ACTI_00050	COG3507	Belongs to the glycosyl hydrolase 43 family
ACTI_00080	COG3250	beta-galactosidase activity
ACTI_00100	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_00160	COG2197	response regulator
ACTI_00170	COG4585	Histidine kinase
ACTI_00200	COG1073	alpha beta
ACTI_00230	COG0583	DNA-binding transcription factor activity
ACTI_00240	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_00250	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_00260	COG1733	regulation of RNA biosynthetic process
ACTI_00330	COG1160	GTP binding
ACTI_00370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACTI_00500	COG0789	Transcriptional regulator
ACTI_00550	COG2267	carboxylic ester hydrolase activity
ACTI_00620	COG1733	regulation of RNA biosynthetic process
ACTI_00660	COG0183	Belongs to the thiolase family
ACTI_00670	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACTI_00670	COG1024	Enoyl-CoA hydratase
ACTI_00700	COG1132	(ABC) transporter
ACTI_00710	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_00720	COG3300	MHYT domain
ACTI_00720	COG5001	Diguanylate cyclase
ACTI_00760	COG2814	Major facilitator Superfamily
ACTI_00770	COG0583	DNA-binding transcription factor activity
ACTI_00800	COG1187	pseudouridine synthase activity
ACTI_00810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACTI_00820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACTI_00950	COG0504	CTP synthase activity
ACTI_01030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACTI_01100	COG0647	UMP catabolic process
ACTI_01130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACTI_01140	COG2326	polyphosphate kinase activity
ACTI_01160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACTI_01170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACTI_01180	COG1063	alcohol dehydrogenase
ACTI_01190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACTI_01190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACTI_01210	COG2213	PTS system mannitol-specific
ACTI_01210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACTI_01230	COG1349	DNA-binding transcription factor activity
ACTI_01250	COG0563	adenylate kinase activity
ACTI_01330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACTI_01340	COG2094	Belongs to the DNA glycosylase MPG family
ACTI_01350	COG3973	AAA domain
ACTI_01370	COG1177	transmembrane transport
ACTI_01380	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACTI_01390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACTI_01400	COG3842	ATPase activity
ACTI_01450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACTI_01460	COG0406	alpha-ribazole phosphatase activity
ACTI_01490	COG0730	response to heat
ACTI_01550	COG1129	ABC transporter
ACTI_01560	COG1744	ABC transporter substrate-binding protein PnrA-like
ACTI_01570	COG1802	Transcriptional regulator
ACTI_01610	COG3833	ABC-type maltose transport systems, permease component
ACTI_01670	COG0165	Argininosuccinate lyase
ACTI_01680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_01690	COG0137	argininosuccinate synthase activity
ACTI_01720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACTI_01730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACTI_01740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACTI_01750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACTI_01760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACTI_01800	COG1733	regulation of RNA biosynthetic process
ACTI_01820	COG3572	ergothioneine biosynthetic process
ACTI_01830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACTI_01840	COG0121	glutamine amidotransferase
ACTI_01850	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACTI_01890	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACTI_01900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ACTI_01910	COG0714	Associated with various cellular activities
ACTI_01920	COG3831	ATPase activity
ACTI_01990	COG0072	phenylalanine-tRNA ligase activity
ACTI_01990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACTI_02000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACTI_02010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACTI_02020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACTI_02030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACTI_02040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACTI_02060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACTI_02070	COG0140	phosphoribosyl-ATP diphosphatase activity
ACTI_02090	COG0765	amino acid transport
ACTI_02110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACTI_02120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACTI_02120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACTI_02170	COG0745	RESPONSE REGULATOR receiver
ACTI_02210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACTI_02220	COG0242	peptide deformylase activity
ACTI_02250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACTI_02270	COG1758	RNA polymerase activity
ACTI_02280	COG0194	GDP metabolic process
ACTI_02300	COG0284	orotidine-5'-phosphate decarboxylase activity
ACTI_02310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACTI_02320	COG0167	dihydroorotate dehydrogenase activity
ACTI_02340	COG0505	Belongs to the CarA family
ACTI_02350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACTI_02360	COG0540	Belongs to the ATCase OTCase family
ACTI_02370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACTI_02400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACTI_02410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACTI_02420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACTI_02430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACTI_02450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACTI_02460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACTI_02470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACTI_02490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACTI_02500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACTI_02510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACTI_02630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACTI_02670	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
ACTI_02690	COG3833	ABC-type maltose transport systems, permease component
ACTI_02730	COG3964	amidohydrolase
ACTI_02740	COG0251	oxidation-reduction process
ACTI_02750	COG0515	serine threonine protein kinase
ACTI_02760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACTI_02760	COG2755	lipolytic protein G-D-S-L family
ACTI_02770	COG2124	cytochrome p450
ACTI_02770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ACTI_02790	COG0831	urea catabolic process
ACTI_02800	COG0832	Belongs to the urease beta subunit family
ACTI_02830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACTI_02840	COG0829	nickel cation binding
ACTI_02890	COG0515	serine threonine protein kinase
ACTI_02900	COG0189	ligase activity
ACTI_02900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACTI_02950	COG0124	histidyl-tRNA synthetase
ACTI_02990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACTI_03000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACTI_03010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACTI_03030	COG1862	Preprotein translocase
ACTI_03040	COG2255	four-way junction helicase activity
ACTI_03050	COG0632	four-way junction helicase activity
ACTI_03060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACTI_03080	COG0217	transcriptional regulatory protein
ACTI_03090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACTI_03100	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACTI_03130	COG0438	transferase activity, transferring glycosyl groups
ACTI_03140	COG1560	Kdo2-lipid A biosynthetic process
ACTI_03210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACTI_03240	COG2205	protein histidine kinase activity
ACTI_03270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACTI_03290	COG0667	Aldo Keto reductase
ACTI_03310	COG1278	Cold shock
ACTI_03390	COG1472	Belongs to the glycosyl hydrolase 3 family
ACTI_03410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_03420	COG0514	ATP-dependent DNA helicase (RecQ)
ACTI_03450	COG0683	leucine binding
ACTI_03460	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACTI_03490	COG0410	ABC transporter
ACTI_03520	COG4106	trans-aconitate 2-methyltransferase activity
ACTI_03530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACTI_03530	COG1672	PFAM Archaeal ATPase
ACTI_03540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACTI_03610	COG2197	response regulator
ACTI_03620	COG4585	Histidine kinase
ACTI_03650	COG0438	transferase activity, transferring glycosyl groups
ACTI_03780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACTI_03830	COG0542	response to heat
ACTI_03900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACTI_03920	COG4266	Belongs to the allantoicase family
ACTI_03930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACTI_04020	COG1643	Atp-dependent helicase
ACTI_04030	COG5001	Diguanylate cyclase
ACTI_04030	COG3300	MHYT domain
ACTI_04070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACTI_04200	COG5002	protein histidine kinase activity
ACTI_04210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACTI_04250	COG0405	Gamma-glutamyltransferase
ACTI_04310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACTI_04330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_04410	COG1686	Belongs to the peptidase S11 family
ACTI_04430	COG1191	sigma factor activity
ACTI_04440	COG3973	AAA domain
ACTI_04460	COG1191	sigma factor activity
ACTI_04470	COG0513	Belongs to the DEAD box helicase family
ACTI_04530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACTI_04540	COG1609	Transcriptional regulator
ACTI_04550	COG4166	transmembrane transport
ACTI_04570	COG0601	transmembrane transport
ACTI_04580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACTI_04590	COG0444	Belongs to the ABC transporter superfamily
ACTI_04640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACTI_04650	COG0187	DNA topoisomerase II activity
ACTI_04700	COG2205	protein histidine kinase activity
ACTI_04710	COG0745	RESPONSE REGULATOR receiver
ACTI_04730	COG0435	Glutathione S-transferase
ACTI_04770	COG0714	Associated with various cellular activities
ACTI_04790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACTI_04800	COG2226	methyltransferase
ACTI_04830	COG1404	Belongs to the peptidase S8 family
ACTI_04900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACTI_04970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACTI_04980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACTI_04980	COG1017	nitric oxide dioxygenase activity
ACTI_05090	COG2755	lipolytic protein G-D-S-L family
ACTI_05110	COG0515	serine threonine protein kinase
ACTI_05130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACTI_05140	COG1136	(ABC) transporter
ACTI_05150	COG1136	(ABC) transporter
ACTI_05180	COG0598	Magnesium transport protein CorA
ACTI_05190	COG3201	nicotinamide mononucleotide transporter
ACTI_05240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACTI_05320	COG3328	transposase activity
ACTI_05330	COG0366	Alpha amylase catalytic
ACTI_05330	COG1874	Beta-galactosidase
ACTI_05360	COG3629	intracellular signal transduction
ACTI_05380	COG0596	Alpha beta hydrolase
ACTI_05390	COG3706	GGDEF domain
ACTI_05390	COG0745	RESPONSE REGULATOR receiver
ACTI_05680	COG2197	response regulator
ACTI_05690	COG4585	Histidine kinase
ACTI_05800	COG1063	alcohol dehydrogenase
ACTI_05830	COG2318	DinB family
ACTI_05850	COG0671	phosphoesterase, PA-phosphatase related
ACTI_05870	COG1803	Methylglyoxal synthase
ACTI_05870	COG1597	lipid kinase activity
ACTI_05940	COG0745	RESPONSE REGULATOR receiver
ACTI_05980	COG2197	response regulator
ACTI_05990	COG3850	Histidine kinase
ACTI_06070	COG1335	isochorismatase
ACTI_06120	COG0800	Aldolase
ACTI_06210	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ACTI_06240	COG0438	transferase activity, transferring glycosyl groups
ACTI_06250	COG0438	transferase activity, transferring glycosyl groups
ACTI_06280	COG2226	methyltransferase
ACTI_06290	COG0673	inositol 2-dehydrogenase activity
ACTI_06320	COG3483	tryptophan 2,3-dioxygenase activity
ACTI_06330	COG3012	SEC-C Motif Domain Protein
ACTI_06340	COG0840	transmembrane signaling receptor activity
ACTI_06350	COG4941	Belongs to the sigma-70 factor family
ACTI_06380	COG1653	transport
ACTI_06390	COG1175	transmembrane transport
ACTI_06400	COG0395	ABC-type sugar transport system, permease component
ACTI_06410	COG0366	Alpha amylase catalytic
ACTI_06430	COG0659	secondary active sulfate transmembrane transporter activity
ACTI_06440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACTI_06450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACTI_06450	COG2308	Evidence 4 Homologs of previously reported genes of
ACTI_06460	COG0367	asparagine synthase
ACTI_06470	COG4946	Tricorn protease homolog
ACTI_06470	COG1506	peptidase
ACTI_06470	COG0823	Involved in the tonB-independent uptake of proteins
ACTI_06530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACTI_06620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACTI_06690	COG2197	response regulator
ACTI_06740	COG1131	(ABC) transporter
ACTI_06750	COG0328	RNA-DNA hybrid ribonuclease activity
ACTI_06850	COG5001	Diguanylate cyclase
ACTI_06860	COG2197	response regulator
ACTI_06870	COG4585	Histidine kinase
ACTI_06900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACTI_06940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACTI_07100	COG2807	transmembrane transport
ACTI_07140	COG0058	SHG alpha-glucan phosphorylase activity
ACTI_07210	COG1960	acyl-CoA dehydrogenase activity
ACTI_07250	COG1309	transcriptional regulator
ACTI_07260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACTI_07280	COG2304	oxidoreductase activity
ACTI_07310	COG0714	Associated with various cellular activities
ACTI_07320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACTI_07340	COG3693	PFAM glycoside hydrolase, family 10
ACTI_07360	COG0714	Associated with various cellular activities
ACTI_07370	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACTI_07400	COG2409	Drug exporters of the RND superfamily
ACTI_07550	COG1309	transcriptional regulator
ACTI_07560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACTI_07580	COG3328	transposase activity
ACTI_07620	COG0633	Ferredoxin
ACTI_07620	COG0543	2 iron, 2 sulfur cluster binding
ACTI_07740	COG3328	transposase activity
ACTI_07780	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ACTI_07820	COG0395	ABC-type sugar transport system, permease component
ACTI_07830	COG1175	transmembrane transport
ACTI_07880	COG1960	acyl-CoA dehydrogenase activity
ACTI_07890	COG5001	Diguanylate cyclase
ACTI_07930	COG2197	response regulator
ACTI_07960	COG0028	Belongs to the TPP enzyme family
ACTI_08030	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_08040	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACTI_08180	COG0419	ATPase involved in DNA repair
ACTI_08190	COG0420	3'-5' exonuclease activity
ACTI_08210	COG1595	DNA-templated transcription, initiation
ACTI_08260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACTI_08270	COG0156	8-amino-7-oxononanoate synthase activity
ACTI_08280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACTI_08320	COG2264	protein methyltransferase activity
ACTI_08410	COG0789	Transcriptional regulator
ACTI_08410	COG4978	Transcriptional regulator
ACTI_08420	COG1793	dna ligase
ACTI_08440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACTI_08460	COG3285	dna ligase
ACTI_08460	COG1793	dna ligase
ACTI_08490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACTI_08510	COG0463	Glycosyl transferase, family 2
ACTI_08530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACTI_08540	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACTI_08550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACTI_08590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACTI_08610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACTI_08620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACTI_08650	COG0183	Belongs to the thiolase family
ACTI_08660	COG1024	Enoyl-CoA hydratase
ACTI_08660	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACTI_08680	COG2205	protein histidine kinase activity
ACTI_08690	COG0745	RESPONSE REGULATOR receiver
ACTI_08730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACTI_08740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACTI_08750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACTI_08760	COG0531	amino acid
ACTI_08770	COG0569	domain protein
ACTI_08820	COG0756	dUTP diphosphatase activity
ACTI_08910	COG2860	membrane
ACTI_08930	COG2313	pseudouridylate synthase activity
ACTI_08940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACTI_08940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACTI_09020	COG0643	Histidine kinase
ACTI_09020	COG2198	Histidine kinase
ACTI_09040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACTI_09060	COG2201	protein-glutamate methylesterase activity
ACTI_09070	COG0835	chemotaxis
ACTI_09080	COG0840	transmembrane signaling receptor activity
ACTI_09080	COG3290	protein histidine kinase activity
ACTI_09100	COG1490	D-aminoacyl-tRNA deacylase activity
ACTI_09190	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACTI_09200	COG0439	Biotin carboxylase
ACTI_09230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACTI_09240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACTI_09260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACTI_09280	COG0584	glycerophosphoryl diester phosphodiesterase
ACTI_09290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACTI_09300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACTI_09310	COG1196	nuclear chromosome segregation
ACTI_09320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACTI_09340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACTI_09360	COG1126	abc transporter atp-binding protein
ACTI_09370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACTI_09380	COG0765	amino acid transport
ACTI_09390	COG0765	amino acid transport
ACTI_09400	COG1418	mRNA catabolic process
ACTI_09410	COG2137	regulation of response to DNA damage stimulus
ACTI_09420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACTI_09430	COG1573	uracil-dna glycosylase
ACTI_09470	COG0515	serine threonine protein kinase
ACTI_09470	COG2815	serine threonine protein kinase
ACTI_09480	COG1201	RNA secondary structure unwinding
ACTI_09520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACTI_09550	COG1396	sequence-specific DNA binding
ACTI_09560	COG1546	Belongs to the CinA family
ACTI_09560	COG1058	Belongs to the CinA family
ACTI_09580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACTI_09620	COG1674	ftsk spoiiie
ACTI_09650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACTI_09660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACTI_09680	COG3214	Protein conserved in bacteria
ACTI_09730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACTI_09750	COG0612	Peptidase, M16
ACTI_09760	COG1185	polyribonucleotide nucleotidyltransferase activity
ACTI_09770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACTI_09790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACTI_09810	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACTI_09820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACTI_09850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACTI_09870	COG0779	Required for maturation of 30S ribosomal subunits
ACTI_09950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACTI_09960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACTI_09980	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_10030	COG4585	Histidine kinase
ACTI_10040	COG2197	response regulator
ACTI_10050	COG4152	abc transporter atp-binding protein
ACTI_10060	COG1668	transmembrane transport
ACTI_10070	COG1309	transcriptional regulator
ACTI_10080	COG1511	domain protein
ACTI_10090	COG1132	(ABC) transporter
ACTI_10120	COG0456	acetyltransferase
ACTI_10140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACTI_10150	COG0750	zinc metalloprotease
ACTI_10190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACTI_10190	COG2146	nitrite reductase [NAD(P)H] activity
ACTI_10220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACTI_10230	COG0575	Belongs to the CDS family
ACTI_10240	COG0233	cytoplasmic translational termination
ACTI_10250	COG0528	UMP kinase activity
ACTI_10260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACTI_10270	COG0052	Belongs to the universal ribosomal protein uS2 family
ACTI_10280	COG0792	nuclease activity
ACTI_10290	COG0606	chelatase, subunit chli
ACTI_10330	COG4974	Belongs to the 'phage' integrase family
ACTI_10370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACTI_10390	COG0681	Belongs to the peptidase S26 family
ACTI_10400	COG0681	Belongs to the peptidase S26 family
ACTI_10410	COG0335	large ribosomal subunit rRNA binding
ACTI_10420	COG0336	Belongs to the RNA methyltransferase TrmD family
ACTI_10430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACTI_10440	COG1837	Belongs to the UPF0109 family
ACTI_10450	COG0228	four-way junction DNA binding
ACTI_10470	COG0442	prolyl-tRNA aminoacylation
ACTI_10480	COG1595	DNA-templated transcription, initiation
ACTI_10550	COG0438	transferase activity, transferring glycosyl groups
ACTI_10570	COG1216	Glycosyl transferase, family 2
ACTI_10610	COG0463	Glycosyl transferase, family 2
ACTI_10630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACTI_10630	COG2755	lipolytic protein G-D-S-L family
ACTI_10650	COG1216	Glycosyl transferase, family 2
ACTI_10650	COG1442	glycosyl transferase family 8
ACTI_10660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACTI_10790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACTI_10810	COG0571	ribonuclease III activity
ACTI_10820	COG0416	fatty acid biosynthetic process
ACTI_10830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACTI_10860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACTI_10870	COG0742	ribosomal rna small subunit methyltransferase
ACTI_10920	COG1461	Dihydroxyacetone kinase
ACTI_10930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACTI_11000	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACTI_11030	COG0626	cystathionine gamma-synthase activity
ACTI_11040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACTI_11080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACTI_11110	COG0776	regulation of translation
ACTI_11120	COG0066	3-isopropylmalate dehydratase activity
ACTI_11170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACTI_11200	COG1476	TRANSCRIPTIONal
ACTI_11220	COG1131	(ABC) transporter
ACTI_11240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACTI_11280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACTI_11290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACTI_11310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACTI_11320	COG0473	3-isopropylmalate dehydrogenase activity
ACTI_11350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACTI_11360	COG0440	acetolactate synthase activity
ACTI_11380	COG5001	Diguanylate cyclase
ACTI_11380	COG4251	negative regulation of phosphorylation
ACTI_11380	COG3706	GGDEF domain
ACTI_11380	COG2203	Gaf domain
ACTI_11390	COG0129	dihydroxy-acid dehydratase activity
ACTI_11420	COG1175	transmembrane transport
ACTI_11440	COG1609	Transcriptional regulator
ACTI_11490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACTI_11500	COG0154	amidase activity
ACTI_11510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACTI_11530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACTI_11550	COG0482	sulfurtransferase activity
ACTI_11570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACTI_11580	COG2086	electron transfer activity
ACTI_11590	COG2149	membrane
ACTI_11620	COG0443	Heat shock 70 kDa protein
ACTI_11660	COG0840	transmembrane signaling receptor activity
ACTI_11670	COG0840	transmembrane signaling receptor activity
ACTI_11680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACTI_11690	COG1119	ATPase activity
ACTI_11700	COG1940	carbohydrate kinase activity
ACTI_11740	COG2902	Dehydrogenase
ACTI_11750	COG0768	penicillin binding
ACTI_11760	COG0010	Belongs to the arginase family
ACTI_11770	COG3118	belongs to the thioredoxin family
ACTI_11820	COG1703	isobutyryl-CoA mutase activity
ACTI_11830	COG0183	Belongs to the thiolase family
ACTI_11940	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ACTI_11970	COG1674	ftsk spoiiie
ACTI_11990	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACTI_12050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACTI_12070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACTI_12080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACTI_12090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACTI_12100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACTI_12110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACTI_12120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACTI_12130	COG0356	it plays a direct role in the translocation of protons across the membrane
ACTI_12160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACTI_12170	COG0702	epimerase
ACTI_12180	COG0009	L-threonylcarbamoyladenylate synthase
ACTI_12190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACTI_12210	COG2890	protein-(glutamine-N5) methyltransferase activity
ACTI_12220	COG3706	GGDEF domain
ACTI_12250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACTI_12260	COG0254	rRNA binding
ACTI_12300	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ACTI_12320	COG0083	homoserine kinase activity
ACTI_12340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACTI_12360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACTI_12370	COG0460	homoserine dehydrogenase
ACTI_12390	COG0018	arginyl-trna synthetase
ACTI_12420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACTI_12440	COG3469	chitinase activity
ACTI_12500	COG0477	Major facilitator Superfamily
ACTI_12580	COG0754	glutathionylspermidine amidase activity
ACTI_12650	COG0586	Pfam SNARE associated Golgi protein
ACTI_12660	COG3469	chitinase activity
ACTI_12690	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACTI_12720	COG0740	serine-type endopeptidase activity
ACTI_12740	COG1834	amidinotransferase
ACTI_12750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACTI_12810	COG3118	belongs to the thioredoxin family
ACTI_12840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACTI_12850	COG2205	protein histidine kinase activity
ACTI_12860	COG0745	RESPONSE REGULATOR receiver
ACTI_12900	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACTI_12900	COG0567	Dehydrogenase, E1 component
ACTI_12920	COG0280	phosphate acetyltransferase
ACTI_12920	COG0857	belongs to the CobB CobQ family
ACTI_12930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACTI_12950	COG1064	alcohol dehydrogenase
ACTI_12990	COG2172	sigma factor antagonist activity
ACTI_13000	COG2188	Transcriptional regulator
ACTI_13020	COG1597	lipid kinase activity
ACTI_13050	COG0175	sulfate reduction
ACTI_13060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACTI_13080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACTI_13100	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ACTI_13120	COG1595	DNA-templated transcription, initiation
ACTI_13150	COG2135	peptidase activity
ACTI_13160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACTI_13170	COG1162	GTPase activity
ACTI_13180	COG0483	inositol monophosphate 1-phosphatase activity
ACTI_13310	COG0861	Integral membrane protein TerC family
ACTI_13320	COG1357	PFAM Pentapeptide repeats (8 copies)
ACTI_13330	COG1615	UPF0182 protein
ACTI_13340	COG3480	Lon protease (S16) C-terminal proteolytic domain
ACTI_13400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACTI_13460	COG2816	NAD+ diphosphatase activity
ACTI_13490	COG1959	2 iron, 2 sulfur cluster binding
ACTI_13510	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ACTI_13520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_13550	COG1278	Cold shock
ACTI_13570	COG0210	DNA helicase
ACTI_13580	COG1074	ATP-dependent DNA helicase activity
ACTI_13600	COG1611	Belongs to the LOG family
ACTI_13610	COG1611	Belongs to the LOG family
ACTI_13630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_13640	COG2171	N-acyltransferase activity
ACTI_13760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACTI_13770	COG1506	peptidase
ACTI_13770	COG0823	Involved in the tonB-independent uptake of proteins
ACTI_13780	COG0312	modulator of DNA gyrase
ACTI_13810	COG1053	succinate dehydrogenase
ACTI_13850	COG0411	ABC transporter
ACTI_13860	COG0410	ABC transporter
ACTI_13900	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_13930	COG1960	acyl-CoA dehydrogenase activity
ACTI_13960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACTI_13990	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_14130	COG0012	GTP binding
ACTI_14150	COG2169	Transcriptional regulator
ACTI_14150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACTI_14160	COG0525	valine-tRNA ligase activity
ACTI_14190	COG1322	Protein conserved in bacteria
ACTI_14200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACTI_14230	COG1570	exodeoxyribonuclease VII activity
ACTI_14240	COG1722	exodeoxyribonuclease VII activity
ACTI_14270	COG0705	Rhomboid family
ACTI_14300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACTI_14310	COG0561	phosphatase activity
ACTI_14310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACTI_14320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACTI_14340	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACTI_14410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACTI_14480	COG0424	maF-like protein
ACTI_14490	COG4770	biotin carboxylase activity
ACTI_14580	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACTI_14580	COG1473	amidohydrolase
ACTI_14590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACTI_14590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACTI_14600	COG2815	serine threonine protein kinase
ACTI_14600	COG0515	serine threonine protein kinase
ACTI_14610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACTI_14630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ACTI_14640	COG1051	belongs to the nudix hydrolase family
ACTI_14660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACTI_14680	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_14690	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_14750	COG2018	Roadblock/LC7 domain
ACTI_14770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACTI_14850	COG1744	ABC transporter substrate-binding protein PnrA-like
ACTI_14900	COG0180	Tryptophanyl-tRNA synthetase
ACTI_14910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACTI_14920	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACTI_14930	COG2856	Zn peptidase
ACTI_14990	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACTI_15010	COG0193	aminoacyl-tRNA hydrolase activity
ACTI_15040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACTI_15070	COG0488	(ABC) transporter
ACTI_15080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACTI_15100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACTI_15110	COG0084	hydrolase, TatD family'
ACTI_15160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACTI_15220	COG0726	polysaccharide deacetylase
ACTI_15390	COG0303	'Molybdopterin
ACTI_15400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACTI_15410	COG0745	RESPONSE REGULATOR receiver
ACTI_15410	COG3706	GGDEF domain
ACTI_15510	COG2095	MarC family integral membrane protein
ACTI_15520	COG0613	PHP domain protein
ACTI_15570	COG3118	belongs to the thioredoxin family
ACTI_15590	COG1832	CoA-binding protein
ACTI_15600	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_15630	COG0546	phosphoglycolate phosphatase activity
ACTI_15650	COG0384	phenazine biosynthesis protein PhzF
ACTI_15660	COG2239	Acts as a magnesium transporter
ACTI_15690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACTI_15700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACTI_15710	COG4122	O-methyltransferase activity
ACTI_15750	COG1024	Enoyl-CoA hydratase
ACTI_15770	COG0519	Catalyzes the synthesis of GMP from XMP
ACTI_15800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACTI_15810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACTI_15810	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACTI_15820	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACTI_15850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACTI_15910	COG0113	porphobilinogen synthase activity
ACTI_15920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACTI_15920	COG1587	Uroporphyrinogen-III synthase
ACTI_15930	COG0181	hydroxymethylbilane synthase activity
ACTI_15940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACTI_15950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ACTI_15980	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_16000	COG1595	DNA-templated transcription, initiation
ACTI_16070	COG0506	proline dehydrogenase activity
ACTI_16090	COG1082	Xylose isomerase domain protein TIM barrel
ACTI_16140	COG0588	phosphoglycerate mutase activity
ACTI_16170	COG0438	transferase activity, transferring glycosyl groups
ACTI_16200	COG0745	RESPONSE REGULATOR receiver
ACTI_16230	COG5002	protein histidine kinase activity
ACTI_16260	COG0739	heme binding
ACTI_16270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACTI_16280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACTI_16300	COG4786	Flagellar basal body rod
ACTI_16300	COG1256	bacterial-type flagellum assembly
ACTI_16340	COG1516	flagellar protein fliS
ACTI_16360	COG1815	bacterial-type flagellum-dependent cell motility
ACTI_16370	COG1558	bacterial-type flagellum-dependent cell motility
ACTI_16380	COG1677	Flagellar hook-basal body complex protein FliE
ACTI_16390	COG1766	The M ring may be actively involved in energy transduction
ACTI_16400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACTI_16440	COG0739	heme binding
ACTI_16440	COG0741	lytic transglycosylase activity
ACTI_16440	COG1196	nuclear chromosome segregation
ACTI_16480	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACTI_16490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACTI_16510	COG1338	Plays a role in the flagellum-specific transport system
ACTI_16530	COG1776	CheC inhibitor of MCP methylation
ACTI_16530	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACTI_16590	COG1749	Flagellar hook protein flgE
ACTI_16600	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ACTI_16620	COG0745	RESPONSE REGULATOR receiver
ACTI_16650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACTI_16660	COG2201	protein-glutamate methylesterase activity
ACTI_16690	COG0643	Histidine kinase
ACTI_16690	COG2198	Histidine kinase
ACTI_16700	COG0745	RESPONSE REGULATOR receiver
ACTI_16710	COG2340	Cysteine-rich secretory protein family
ACTI_16720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACTI_16830	COG3246	L-lysine catabolic process to acetate
ACTI_16850	COG0735	belongs to the Fur family
ACTI_16870	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ACTI_16900	COG0494	nUDIX hydrolase
ACTI_16930	COG1595	DNA-templated transcription, initiation
ACTI_16960	COG0306	phosphate transporter
ACTI_16970	COG0673	inositol 2-dehydrogenase activity
ACTI_17000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACTI_17030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACTI_17040	COG0456	acetyltransferase
ACTI_17050	COG0745	RESPONSE REGULATOR receiver
ACTI_17120	COG2339	peptidase activity
ACTI_17130	COG4129	membrane
ACTI_17180	COG0459	protein refolding
ACTI_17210	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACTI_17250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACTI_17280	COG1131	(ABC) transporter
ACTI_17290	COG1349	DNA-binding transcription factor activity
ACTI_17300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACTI_17410	COG3842	ATPase activity
ACTI_17430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACTI_17440	COG0215	cysteine-tRNA ligase activity
ACTI_17450	COG1404	Belongs to the peptidase S8 family
ACTI_17460	COG0114	fumarate hydratase activity
ACTI_17470	COG3903	Transcriptional regulator
ACTI_17470	COG3629	intracellular signal transduction
ACTI_17490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACTI_17490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACTI_17530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACTI_17600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACTI_17610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACTI_17660	COG1960	acyl-CoA dehydrogenase activity
ACTI_17670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACTI_17700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACTI_17710	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ACTI_17740	COG0242	peptide deformylase activity
ACTI_17750	COG3830	Belongs to the UPF0237 family
ACTI_17780	COG0542	response to heat
ACTI_17800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACTI_17810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACTI_17830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACTI_17850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACTI_17860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACTI_17890	COG0649	NAD binding
ACTI_17960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACTI_17970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACTI_18030	COG0741	lytic transglycosylase activity
ACTI_18030	COG1196	nuclear chromosome segregation
ACTI_18030	COG0739	heme binding
ACTI_18090	COG1674	ftsk spoiiie
ACTI_18120	COG0302	gtp cyclohydrolase
ACTI_18130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACTI_18150	COG0037	tRNA processing
ACTI_18180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACTI_18200	COG1674	ftsk spoiiie
ACTI_18240	COG1408	metallophosphoesterase
ACTI_18250	COG1610	YqeY-like protein
ACTI_18260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACTI_18280	COG0003	Pfam Anion-transporting ATPase
ACTI_18330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACTI_18360	COG0439	Biotin carboxylase
ACTI_18400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACTI_18410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACTI_18450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACTI_18490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACTI_18550	COG4608	Belongs to the ABC transporter superfamily
ACTI_18600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACTI_18610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACTI_18670	COG0813	purine-nucleoside phosphorylase activity
ACTI_18680	COG0590	tRNA wobble adenosine to inosine editing
ACTI_18730	COG0287	Prephenate dehydrogenase
ACTI_18740	COG2318	DinB family
ACTI_18750	COG0235	Class ii aldolase
ACTI_18750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACTI_18760	COG1796	DNA polymerase
ACTI_18760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACTI_18790	COG0642	Histidine kinase
ACTI_18800	COG2018	Roadblock/LC7 domain
ACTI_18850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACTI_18860	COG5298	Protein conserved in bacteria
ACTI_18930	COG0477	Major facilitator Superfamily
ACTI_18940	COG3706	GGDEF domain
ACTI_19020	COG0778	Nitroreductase
ACTI_19030	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACTI_19080	COG3397	chitin binding
ACTI_19130	COG1268	BioY protein
ACTI_19210	COG0667	Aldo Keto reductase
ACTI_19260	COG0673	inositol 2-dehydrogenase activity
ACTI_19290	COG3866	Pectate lyase
ACTI_19300	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ACTI_19310	COG3831	ATPase activity
ACTI_19360	COG4558	Periplasmic binding protein
ACTI_19370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_19380	COG1120	ATPase activity
ACTI_19400	COG3629	intracellular signal transduction
ACTI_19400	COG3903	Transcriptional regulator
ACTI_19480	COG1216	Glycosyl transferase, family 2
ACTI_19490	COG0438	transferase activity, transferring glycosyl groups
ACTI_19510	COG1595	DNA-templated transcription, initiation
ACTI_19610	COG2208	phosphoserine phosphatase activity
ACTI_19610	COG2770	Histidine kinase
ACTI_19710	COG0438	transferase activity, transferring glycosyl groups
ACTI_19740	COG1803	Methylglyoxal synthase
ACTI_19740	COG1597	lipid kinase activity
ACTI_19860	COG0419	ATPase involved in DNA repair
ACTI_19930	COG4974	Belongs to the 'phage' integrase family
ACTI_19940	COG0494	nUDIX hydrolase
ACTI_19960	COG2188	Transcriptional regulator
ACTI_20060	COG0242	peptide deformylase activity
ACTI_20100	COG1881	PFAM PEBP family protein
ACTI_20140	COG0789	Transcriptional regulator
ACTI_20150	COG3959	Transketolase, thiamine diphosphate binding domain
ACTI_20160	COG3958	Transketolase
ACTI_20190	COG0705	Rhomboid family
ACTI_20200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACTI_20230	COG0598	Magnesium transport protein CorA
ACTI_20240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACTI_20260	COG0371	Dehydrogenase
ACTI_20290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACTI_20310	COG3275	phosphorelay sensor kinase activity
ACTI_20330	COG0745	RESPONSE REGULATOR receiver
ACTI_20340	COG2205	protein histidine kinase activity
ACTI_20370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACTI_20440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACTI_20510	COG2235	arginine
ACTI_20600	COG1764	response to oxidative stress
ACTI_20620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACTI_20630	COG0561	phosphatase activity
ACTI_20640	COG0561	phosphatase activity
ACTI_20660	COG1834	amidinotransferase
ACTI_20700	COG0746	molybdenum cofactor guanylyltransferase activity
ACTI_20710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACTI_20720	COG3540	Alkaline phosphatase
ACTI_20760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACTI_20860	COG0315	cyclic pyranopterin monophosphate synthase activity
ACTI_20860	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACTI_20870	COG0315	cyclic pyranopterin monophosphate synthase activity
ACTI_20880	COG5001	Diguanylate cyclase
ACTI_20920	COG0305	Participates in initiation and elongation during chromosome replication
ACTI_20940	COG0359	binds to the 23S rRNA
ACTI_20950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACTI_20960	COG0629	single-stranded DNA binding
ACTI_20970	COG0360	Binds together with S18 to 16S ribosomal RNA
ACTI_21020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACTI_21060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACTI_21100	COG3409	Peptidoglycan-binding domain 1 protein
ACTI_21110	COG0617	tRNA 3'-terminal CCA addition
ACTI_21140	COG2815	serine threonine protein kinase
ACTI_21140	COG0515	serine threonine protein kinase
ACTI_21150	COG1595	DNA-templated transcription, initiation
ACTI_21190	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACTI_21190	COG3409	Peptidoglycan-binding domain 1 protein
ACTI_21210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACTI_21220	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACTI_21260	COG3293	Transposase
ACTI_21280	COG1192	Involved in chromosome partitioning
ACTI_21290	COG0357	Ribosomal RNA small subunit methyltransferase G
ACTI_21310	COG0706	membrane insertase activity
ACTI_21320	COG0594	ribonuclease P activity
ACTI_21330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACTI_21350	COG0592	DNA-directed DNA polymerase activity
ACTI_21360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACTI_21370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACTI_21380	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ACTI_21410	COG0187	DNA topoisomerase II activity
ACTI_21420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACTI_21450	COG5650	phosphatidylinositol metabolic process
ACTI_21470	COG2816	NAD+ diphosphatase activity
ACTI_21500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACTI_21530	COG0442	prolyl-tRNA aminoacylation
ACTI_21600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACTI_21630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACTI_21640	COG1960	acyl-CoA dehydrogenase activity
ACTI_21650	COG1846	Transcriptional regulator
ACTI_21750	COG1716	ATPase activity
ACTI_21750	COG1716	ATPase activity
ACTI_21760	COG1716	ATPase activity
ACTI_21800	COG0768	penicillin binding
ACTI_21810	COG0515	serine threonine protein kinase
ACTI_21820	COG0515	serine threonine protein kinase
ACTI_21820	COG2815	serine threonine protein kinase
ACTI_21880	COG0247	lactate metabolic process
ACTI_21880	COG2181	nitrate reductase activity
ACTI_21940	COG0717	Belongs to the dCTP deaminase family
ACTI_21960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACTI_21970	COG2208	phosphoserine phosphatase activity
ACTI_21970	COG2770	Histidine kinase
ACTI_21990	COG1960	acyl-CoA dehydrogenase activity
ACTI_22060	COG0588	phosphoglycerate mutase activity
ACTI_22090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACTI_22100	COG1984	allophanate hydrolase subunit 2
ACTI_22150	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACTI_22160	COG0022	dehydrogenase e1 component
ACTI_22220	COG0443	Heat shock 70 kDa protein
ACTI_22230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACTI_22240	COG0484	heat shock protein binding
ACTI_22250	COG0789	Transcriptional regulator
ACTI_22290	COG2814	Major facilitator Superfamily
ACTI_22300	COG0542	response to heat
ACTI_22360	COG0640	Transcriptional regulator
ACTI_22380	COG0586	Pfam SNARE associated Golgi protein
ACTI_22390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACTI_22510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACTI_22520	COG0151	Belongs to the GarS family
ACTI_22540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACTI_22560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACTI_22570	COG0047	phosphoribosylformylglycinamidine synthase activity
ACTI_22580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACTI_22620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACTI_22630	COG0641	radical SAM
ACTI_22700	COG2226	methyltransferase
ACTI_22710	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ACTI_22840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ACTI_22920	COG0438	transferase activity, transferring glycosyl groups
ACTI_22970	COG1970	mechanosensitive ion channel activity
ACTI_22990	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_23000	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_23010	COG2172	sigma factor antagonist activity
ACTI_23030	COG2205	protein histidine kinase activity
ACTI_23030	COG0784	Response regulator, receiver
ACTI_23040	COG0745	RESPONSE REGULATOR receiver
ACTI_23060	COG1136	(ABC) transporter
ACTI_23100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACTI_23110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACTI_23130	COG0784	Response regulator, receiver
ACTI_23130	COG2205	protein histidine kinase activity
ACTI_23140	COG0745	RESPONSE REGULATOR receiver
ACTI_23180	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_23190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACTI_23200	COG0406	alpha-ribazole phosphatase activity
ACTI_23210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACTI_23240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACTI_23260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACTI_23270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACTI_23280	COG1595	DNA-templated transcription, initiation
ACTI_23300	COG0163	prenyltransferase activity
ACTI_23340	COG0513	Belongs to the DEAD box helicase family
ACTI_23360	COG0791	NLP P60 protein
ACTI_23370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACTI_23410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_23420	COG1120	ATPase activity
ACTI_23430	COG1987	bacterial-type flagellum assembly
ACTI_23480	COG3973	AAA domain
ACTI_23510	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACTI_23520	COG0667	Aldo Keto reductase
ACTI_23530	COG4279	zinc finger
ACTI_23540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACTI_23550	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACTI_23560	COG2226	methyltransferase
ACTI_23600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACTI_23610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACTI_23620	COG0649	NAD binding
ACTI_23650	COG1034	ATP synthesis coupled electron transport
ACTI_23660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACTI_23670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACTI_23690	COG0713	ATP synthesis coupled electron transport
ACTI_23720	COG1007	ATP synthesis coupled electron transport
ACTI_23790	COG1950	PFAM Membrane protein of
ACTI_23850	COG0596	Alpha beta hydrolase
ACTI_23900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACTI_24020	COG1205	dead DEAH box helicase
ACTI_24020	COG1111	helicase
ACTI_24030	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_24050	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACTI_24080	COG1754	DNA topoisomerase type I activity
ACTI_24080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACTI_24100	COG1309	transcriptional regulator
ACTI_24120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACTI_24130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACTI_24190	COG1774	PSP1 C-terminal conserved region
ACTI_24210	COG3594	Acyltransferase
ACTI_24230	COG0693	protein deglycase activity
ACTI_24300	COG0644	oxidoreductase
ACTI_24330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACTI_24350	COG3285	dna ligase
ACTI_24350	COG1793	dna ligase
ACTI_24380	COG0133	tryptophan synthase activity
ACTI_24390	COG0159	tryptophan synthase activity
ACTI_24410	COG1061	Type III restriction enzyme res subunit
ACTI_24440	COG0546	phosphoglycolate phosphatase activity
ACTI_24450	COG1278	Cold shock
ACTI_24460	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACTI_24490	COG2723	6-phospho-beta-galactosidase activity
ACTI_24520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACTI_24530	COG2814	Major facilitator Superfamily
ACTI_24560	COG2252	PERMEase
ACTI_24580	COG2814	Major facilitator Superfamily
ACTI_24640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACTI_24660	COG0259	pyridoxamine-phosphate oxidase activity
ACTI_24680	COG2017	converts alpha-aldose to the beta-anomer
ACTI_24740	COG3842	ATPase activity
ACTI_24810	COG1134	teichoic acid transport
ACTI_24810	COG1388	LysM domain
ACTI_24830	COG1309	transcriptional regulator
ACTI_24920	COG0604	alcohol dehydrogenase
ACTI_24940	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ACTI_24970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACTI_24980	COG1086	Polysaccharide biosynthesis protein
ACTI_25010	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_25060	COG2197	response regulator
ACTI_25120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACTI_25130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACTI_25170	COG2089	acid synthase
ACTI_25190	COG1216	Glycosyl transferase, family 2
ACTI_25200	COG5001	Diguanylate cyclase
ACTI_25200	COG3300	MHYT domain
ACTI_25280	COG2119	membrane
ACTI_25380	COG0586	Pfam SNARE associated Golgi protein
ACTI_25390	COG1191	sigma factor activity
ACTI_25420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACTI_25500	COG1309	transcriptional regulator
ACTI_25510	COG1131	(ABC) transporter
ACTI_25520	COG3559	Exporter of polyketide antibiotics
ACTI_25530	COG0025	NhaP-type Na H and K H
ACTI_25550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACTI_25590	COG1088	dTDP-glucose 4,6-dehydratase activity
ACTI_25610	COG2814	Major facilitator Superfamily
ACTI_25620	COG0673	inositol 2-dehydrogenase activity
ACTI_25720	COG3268	Saccharopine dehydrogenase
ACTI_25730	COG1652	LysM domain
ACTI_25750	COG0583	DNA-binding transcription factor activity
ACTI_25790	COG1686	Belongs to the peptidase S11 family
ACTI_25800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACTI_25820	COG0737	Belongs to the 5'-nucleotidase family
ACTI_25850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACTI_25850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACTI_25860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACTI_25870	COG2205	protein histidine kinase activity
ACTI_25880	COG0745	RESPONSE REGULATOR receiver
ACTI_25910	COG1193	negative regulation of DNA recombination
ACTI_25940	COG0745	RESPONSE REGULATOR receiver
ACTI_25950	COG4251	negative regulation of phosphorylation
ACTI_25960	COG0784	Response regulator, receiver
ACTI_25970	COG0483	inositol monophosphate 1-phosphatase activity
ACTI_25980	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_26020	COG0515	serine threonine protein kinase
ACTI_26020	COG2815	serine threonine protein kinase
ACTI_26030	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_26070	COG2217	Heavy metal translocating P-type atpase
ACTI_26110	COG0513	Belongs to the DEAD box helicase family
ACTI_26210	COG0438	transferase activity, transferring glycosyl groups
ACTI_26210	COG1216	Glycosyl transferase, family 2
ACTI_26250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACTI_26260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACTI_26280	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACTI_26330	COG2211	Major facilitator Superfamily
ACTI_26350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACTI_26360	COG0181	hydroxymethylbilane synthase activity
ACTI_26420	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACTI_26430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACTI_26450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACTI_26470	COG0713	ATP synthesis coupled electron transport
ACTI_26480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACTI_26500	COG1007	ATP synthesis coupled electron transport
ACTI_26520	COG1595	DNA-templated transcription, initiation
ACTI_26550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_26560	COG0501	Belongs to the peptidase M48B family
ACTI_26580	COG1666	GTP binding
ACTI_26620	COG3300	MHYT domain
ACTI_26620	COG5001	Diguanylate cyclase
ACTI_26630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACTI_26640	COG2030	dehydratase
ACTI_26680	COG0081	regulation of translation
ACTI_26710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACTI_26720	COG0222	ribosome binding
ACTI_26730	COG0085	RNA polymerase activity
ACTI_26740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACTI_26770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACTI_26780	COG0049	tRNA binding
ACTI_26790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACTI_26800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACTI_26810	COG0051	transcription antitermination factor activity, RNA binding
ACTI_26820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACTI_26830	COG0088	Forms part of the polypeptide exit tunnel
ACTI_26840	COG0089	rRNA binding
ACTI_26850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACTI_26860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACTI_26870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACTI_26880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACTI_26890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACTI_26900	COG0255	Belongs to the universal ribosomal protein uL29 family
ACTI_26910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACTI_26920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACTI_26930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACTI_26940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACTI_26950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACTI_26960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACTI_26970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACTI_26980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACTI_26990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACTI_27000	COG1841	ribosomal large subunit assembly
ACTI_27010	COG0200	Binds to the 23S rRNA
ACTI_27030	COG0563	adenylate kinase activity
ACTI_27060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACTI_27070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACTI_27080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACTI_27090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACTI_27110	COG0203	ribosomal protein L17
ACTI_27120	COG0101	tRNA pseudouridine synthase activity
ACTI_27150	COG0488	(ABC) transporter
ACTI_27160	COG0352	thiamine-phosphate diphosphorylase activity
ACTI_27170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACTI_27170	COG2022	thiamine diphosphate biosynthetic process
ACTI_27190	COG2022	thiamine diphosphate biosynthetic process
ACTI_27200	COG0352	thiamine-phosphate diphosphorylase activity
ACTI_27210	COG0351	phosphomethylpyrimidine kinase
ACTI_27220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACTI_27270	COG2205	protein histidine kinase activity
ACTI_27280	COG2018	Roadblock/LC7 domain
ACTI_27340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACTI_27350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACTI_27360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACTI_27390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACTI_27420	COG0736	holo-[acyl-carrier-protein] synthase activity
ACTI_27440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACTI_27460	COG0802	atpase or kinase
ACTI_27470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACTI_27480	COG0456	acetyltransferase
ACTI_27480	COG1214	PFAM Peptidase M22, glycoprotease
ACTI_27500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACTI_27530	COG1132	(ABC) transporter
ACTI_27540	COG0459	protein refolding
ACTI_27550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACTI_27570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACTI_27600	COG4214	carbohydrate transport
ACTI_27670	COG2197	response regulator
ACTI_27700	COG0516	GMP reductase activity
ACTI_27720	COG1316	TRANSCRIPTIONal
ACTI_27740	COG1404	Belongs to the peptidase S8 family
ACTI_27750	COG0519	Catalyzes the synthesis of GMP from XMP
ACTI_27750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACTI_27780	COG1183	phosphatidylcholine synthase activity
ACTI_27790	COG0688	phosphatidylethanolamine metabolic process
ACTI_27820	COG4585	Histidine kinase
ACTI_27830	COG2197	response regulator
ACTI_27840	COG4166	transmembrane transport
ACTI_27870	COG0444	Belongs to the ABC transporter superfamily
ACTI_27880	COG4608	Belongs to the ABC transporter superfamily
ACTI_27890	COG1605	Chorismate mutase
ACTI_27900	COG0737	Belongs to the 5'-nucleotidase family
ACTI_27900	COG1525	nuclease
ACTI_27900	COG4085	toxin activity
ACTI_27920	COG0739	heme binding
ACTI_27920	COG0741	lytic transglycosylase activity
ACTI_27920	COG1196	nuclear chromosome segregation
ACTI_27940	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACTI_27960	COG0045	succinate-CoA ligase (ADP-forming) activity
ACTI_28010	COG0138	bifunctional purine biosynthesis protein purh
ACTI_28030	COG0538	isocitrate dehydrogenase activity
ACTI_28040	COG1454	alcohol dehydrogenase
ACTI_28040	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_28060	COG1349	DNA-binding transcription factor activity
ACTI_28190	COG0529	Catalyzes the synthesis of activated sulfate
ACTI_28210	COG1131	(ABC) transporter
ACTI_28250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACTI_28290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACTI_28290	COG1024	Enoyl-CoA hydratase
ACTI_28410	COG0148	phosphopyruvate hydratase activity
ACTI_28440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACTI_28520	COG0714	Associated with various cellular activities
ACTI_28580	COG0183	Belongs to the thiolase family
ACTI_28640	COG3293	Transposase
ACTI_28680	COG2326	polyphosphate kinase activity
ACTI_28690	COG1234	tRNA 3'-trailer cleavage
ACTI_28720	COG1191	sigma factor activity
ACTI_28800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACTI_28810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACTI_28830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACTI_28880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACTI_28890	COG1331	Highly conserved protein containing a thioredoxin domain
ACTI_29070	COG0477	Major facilitator Superfamily
ACTI_29100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACTI_29120	COG0438	transferase activity, transferring glycosyl groups
ACTI_29150	COG0778	Nitroreductase
ACTI_29150	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ACTI_29180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACTI_29220	COG0726	polysaccharide deacetylase
ACTI_29240	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_29260	COG1515	deoxyribonuclease V activity
ACTI_29270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACTI_29280	COG2835	tetraacyldisaccharide 4'-kinase activity
ACTI_29330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACTI_29360	COG0745	RESPONSE REGULATOR receiver
ACTI_29370	COG5002	protein histidine kinase activity
ACTI_29370	COG5000	phosphorelay sensor kinase activity
ACTI_29400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACTI_29410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACTI_29420	COG0653	protein targeting
ACTI_29480	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_29500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACTI_29510	COG2884	Cell division ATP-binding protein ftsE
ACTI_29520	COG2177	Part of the ABC transporter FtsEX involved in
ACTI_29530	COG0739	heme binding
ACTI_29540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACTI_29580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACTI_29590	COG1678	Uncharacterized ACR, COG1678
ACTI_29650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACTI_29670	COG1459	type II secretion system
ACTI_29690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACTI_29720	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_29900	COG5001	Diguanylate cyclase
ACTI_29900	COG5002	protein histidine kinase activity
ACTI_29950	COG3285	dna ligase
ACTI_29950	COG1793	dna ligase
ACTI_29960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_29970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACTI_30020	COG1335	isochorismatase
ACTI_30030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACTI_30040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACTI_30100	COG1234	tRNA 3'-trailer cleavage
ACTI_30110	COG0438	transferase activity, transferring glycosyl groups
ACTI_30120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACTI_30130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACTI_30150	COG1228	amidohydrolase
ACTI_30180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACTI_30300	COG2372	response to copper ion
ACTI_30300	COG1276	copper resistance
ACTI_30330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACTI_30340	COG5297	Belongs to the glycosyl hydrolase family 6
ACTI_30380	COG3226	Transcriptional regulator
ACTI_30430	COG3012	SEC-C Motif Domain Protein
ACTI_30430	COG3318	Belongs to the UPF0149 family
ACTI_30450	COG0431	NADPH-dependent FMN reductase
ACTI_30460	COG3119	arylsulfatase activity
ACTI_30480	COG2124	cytochrome p450
ACTI_30510	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_30540	COG3300	MHYT domain
ACTI_30540	COG5001	Diguanylate cyclase
ACTI_30650	COG1472	Belongs to the glycosyl hydrolase 3 family
ACTI_30680	COG4209	transmembrane transport
ACTI_30690	COG0395	ABC-type sugar transport system, permease component
ACTI_30710	COG4977	sequence-specific DNA binding
ACTI_30740	COG0277	FAD linked oxidase domain protein
ACTI_30760	COG0745	RESPONSE REGULATOR receiver
ACTI_30850	COG0456	acetyltransferase
ACTI_30880	COG2124	cytochrome p450
ACTI_30970	COG3903	Transcriptional regulator
ACTI_30970	COG3629	intracellular signal transduction
ACTI_30990	COG1609	Transcriptional regulator
ACTI_31000	COG2706	6-phosphogluconolactonase activity
ACTI_31020	COG1940	carbohydrate kinase activity
ACTI_31030	COG2115	Belongs to the xylose isomerase family
ACTI_31040	COG1070	Carbohydrate kinase
ACTI_31100	COG0366	Alpha amylase catalytic
ACTI_31110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACTI_31170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACTI_31200	COG1388	LysM domain
ACTI_31200	COG3103	Sh3 type 3 domain protein
ACTI_31200	COG0791	NLP P60 protein
ACTI_31210	COG2814	Major facilitator Superfamily
ACTI_31300	COG2264	protein methyltransferase activity
ACTI_31340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACTI_31380	COG0577	efflux transmembrane transporter activity
ACTI_31390	COG1136	(ABC) transporter
ACTI_31390	COG0577	efflux transmembrane transporter activity
ACTI_31420	COG0745	RESPONSE REGULATOR receiver
ACTI_31430	COG2205	protein histidine kinase activity
ACTI_31530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACTI_31560	COG0629	single-stranded DNA binding
ACTI_31580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACTI_31590	COG1492	cobalamin metabolic process
ACTI_31600	COG0501	Belongs to the peptidase M48B family
ACTI_31610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_31640	COG1793	dna ligase
ACTI_31670	COG1797	cobyrinic acid a,c-diamide synthase activity
ACTI_31710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACTI_31720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACTI_31720	COG1648	precorrin-2 dehydrogenase activity
ACTI_31730	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACTI_31820	COG0668	transmembrane transport
ACTI_31870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACTI_31900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACTI_31930	COG0698	ribose 5-phosphate isomerase
ACTI_31940	COG4552	Acetyltransferase involved in intracellular survival and related
ACTI_31960	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_31970	COG0463	Glycosyl transferase, family 2
ACTI_32000	COG0640	Transcriptional regulator
ACTI_32010	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACTI_32020	COG0740	serine-type endopeptidase activity
ACTI_32030	COG0740	serine-type endopeptidase activity
ACTI_32040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACTI_32050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACTI_32080	COG0525	valine-tRNA ligase activity
ACTI_32090	COG0285	dihydrofolate synthase activity
ACTI_32120	COG0105	UTP biosynthetic process
ACTI_32150	COG1131	(ABC) transporter
ACTI_32170	COG0840	transmembrane signaling receptor activity
ACTI_32180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACTI_32220	COG0596	Alpha beta hydrolase
ACTI_32240	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_32270	COG1530	ribonuclease E activity
ACTI_32290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACTI_32300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACTI_32310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACTI_32330	COG0180	Tryptophanyl-tRNA synthetase
ACTI_32370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACTI_32390	COG0406	alpha-ribazole phosphatase activity
ACTI_32410	COG1307	EDD domain protein, DegV family
ACTI_32430	COG2890	protein-(glutamine-N5) methyltransferase activity
ACTI_32450	COG0658	competence protein
ACTI_32450	COG2333	competence protein COMEC
ACTI_32480	COG0268	Binds directly to 16S ribosomal RNA
ACTI_32520	COG0481	GTPase activity
ACTI_32530	COG2261	transglycosylase associated protein
ACTI_32560	COG1024	Enoyl-CoA hydratase
ACTI_32600	COG1420	regulation of RNA biosynthetic process
ACTI_32610	COG0484	heat shock protein binding
ACTI_32620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACTI_32640	COG0537	adenosine 5'-monophosphoramidase activity
ACTI_32670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACTI_32700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACTI_32730	COG1381	Involved in DNA repair and RecF pathway recombination
ACTI_32740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACTI_32850	COG4172	Belongs to the ABC transporter superfamily
ACTI_32860	COG4721	ABC-type cobalt transport system, permease component
ACTI_32870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACTI_32930	COG1121	(ABC) transporter
ACTI_32940	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACTI_32940	COG3443	Belongs to the bacterial solute-binding protein 9 family
ACTI_32980	COG0423	glycine-tRNA ligase activity
ACTI_32990	COG3608	succinylglutamate desuccinylase aspartoacylase
ACTI_32990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACTI_33020	COG4585	Histidine kinase
ACTI_33030	COG2197	response regulator
ACTI_33080	COG2018	Roadblock/LC7 domain
ACTI_33130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACTI_33160	COG1131	(ABC) transporter
ACTI_33190	COG1295	ribonuclease BN
ACTI_33200	COG1940	carbohydrate kinase activity
ACTI_33200	COG1846	Transcriptional regulator
ACTI_33210	COG1129	ABC transporter
ACTI_33220	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACTI_33330	COG4115	mRNA cleavage
ACTI_33340	COG2161	toxin-antitoxin pair type II binding
ACTI_33400	COG0410	ABC transporter
ACTI_33430	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACTI_33490	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_33500	COG0789	Transcriptional regulator
ACTI_33520	COG1957	nucleoside hydrolase
ACTI_33540	COG0698	ribose 5-phosphate isomerase
ACTI_33560	COG3831	ATPase activity
ACTI_33570	COG1505	serine-type exopeptidase activity
ACTI_33710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACTI_33720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACTI_33730	COG1414	Transcriptional regulator
ACTI_33740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACTI_33770	COG1192	Involved in chromosome partitioning
ACTI_33810	COG3979	chitinase
ACTI_33880	COG3401	FG-GAP repeat protein
ACTI_33910	COG0018	arginyl-trna synthetase
ACTI_33920	COG0737	Belongs to the 5'-nucleotidase family
ACTI_33940	COG0515	serine threonine protein kinase
ACTI_33970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACTI_33980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACTI_33980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACTI_34020	COG3973	AAA domain
ACTI_34070	COG1472	Belongs to the glycosyl hydrolase 3 family
ACTI_34100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACTI_34110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACTI_34170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACTI_34190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACTI_34200	COG0432	Pfam Uncharacterised protein family UPF0047
ACTI_34280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACTI_34300	COG0328	RNA-DNA hybrid ribonuclease activity
ACTI_34300	COG0406	alpha-ribazole phosphatase activity
ACTI_34360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACTI_34380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACTI_34400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACTI_34420	COG0730	response to heat
ACTI_34470	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ACTI_34490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACTI_34500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACTI_34500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACTI_34510	COG0174	glutamine synthetase
ACTI_34530	COG1595	DNA-templated transcription, initiation
ACTI_34540	COG3766	membrane
ACTI_34560	COG1064	alcohol dehydrogenase
ACTI_34580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACTI_34600	COG1846	Transcriptional regulator
ACTI_34760	COG1674	ftsk spoiiie
ACTI_34820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACTI_34820	COG1672	PFAM Archaeal ATPase
ACTI_34840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACTI_34850	COG0017	Asparaginyl-tRNA synthetase
ACTI_34870	COG0321	lipoyl(octanoyl) transferase activity
ACTI_34890	COG1090	epimerase
ACTI_34900	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACTI_34910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACTI_34930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACTI_34940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACTI_34950	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACTI_34980	COG1994	Peptidase M50
ACTI_34990	COG0667	Aldo Keto reductase
ACTI_35040	COG4555	ABC transporter
ACTI_35050	COG1396	sequence-specific DNA binding
ACTI_35060	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACTI_35090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACTI_35100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACTI_35110	COG1929	Belongs to the glycerate kinase type-1 family
ACTI_35150	COG0425	Belongs to the sulfur carrier protein TusA family
ACTI_35160	COG1104	cysteine desulfurase activity
ACTI_35170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACTI_35200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACTI_35230	COG1845	cytochrome c oxidase, subunit III
ACTI_35260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACTI_35280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACTI_35300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACTI_35340	COG0501	Belongs to the peptidase M48B family
ACTI_35350	COG0438	transferase activity, transferring glycosyl groups
ACTI_35360	COG1132	(ABC) transporter
ACTI_35410	COG2197	response regulator
ACTI_35460	COG1940	carbohydrate kinase activity
ACTI_35480	COG2072	flavoprotein involved in K transport
ACTI_35520	COG0204	Acyl-transferase
ACTI_35580	COG1846	Transcriptional regulator
ACTI_35580	COG1940	carbohydrate kinase activity
ACTI_35590	COG2211	Major facilitator Superfamily
ACTI_35620	COG0205	6-phosphofructokinase activity
ACTI_35720	COG0386	Belongs to the glutathione peroxidase family
ACTI_35740	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACTI_35780	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACTI_35790	COG0515	serine threonine protein kinase
ACTI_35790	COG2815	serine threonine protein kinase
ACTI_35880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_35930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACTI_35940	COG1053	succinate dehydrogenase
ACTI_35970	COG2226	methyltransferase
ACTI_35990	COG1233	COG1233 Phytoene dehydrogenase and related
ACTI_36120	COG0587	DNA-directed DNA polymerase activity
ACTI_36190	COG0714	Associated with various cellular activities
ACTI_36200	COG0495	leucyl-tRNA aminoacylation
ACTI_36220	COG3442	glutamine amidotransferase
ACTI_36250	COG2001	Belongs to the MraZ family
ACTI_36260	COG0275	rRNA processing
ACTI_36280	COG0768	penicillin binding
ACTI_36290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACTI_36310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACTI_36330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACTI_36340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACTI_36350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACTI_36360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACTI_36370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACTI_36380	COG1799	cell septum assembly
ACTI_36440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACTI_36480	COG0587	DNA-directed DNA polymerase activity
ACTI_36500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACTI_36510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACTI_36520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACTI_36530	COG0131	Imidazoleglycerol-phosphate dehydratase
ACTI_36570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACTI_36580	COG0583	DNA-binding transcription factor activity
ACTI_36600	COG0107	imidazoleglycerol-phosphate synthase activity
ACTI_36610	COG3550	peptidyl-serine autophosphorylation
ACTI_36650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACTI_36670	COG1022	Amp-dependent synthetase and ligase
ACTI_36690	COG0531	amino acid
ACTI_36710	COG1132	(ABC) transporter
ACTI_36720	COG1132	(ABC) transporter
ACTI_36730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACTI_36760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACTI_36810	COG0133	tryptophan synthase activity
ACTI_36820	COG0159	tryptophan synthase activity
ACTI_36830	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACTI_36860	COG0067	glutamate synthase
ACTI_36860	COG0069	glutamate synthase activity
ACTI_36860	COG0070	glutamate synthase
ACTI_36890	COG1946	Acyl-CoA thioesterase
ACTI_36920	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACTI_36980	COG0640	Transcriptional regulator
ACTI_37010	COG2226	methyltransferase
ACTI_37020	COG0539	negative regulation of cytoplasmic translation
ACTI_37030	COG0237	dephospho-CoA kinase activity
ACTI_37030	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ACTI_37050	COG2329	Antibiotic biosynthesis monooxygenase
ACTI_37070	COG0861	Integral membrane protein TerC family
ACTI_37100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACTI_37110	COG0740	serine-type endopeptidase activity
ACTI_37170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACTI_37190	COG1162	GTPase activity
ACTI_37210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACTI_37230	COG0322	excinuclease ABC activity
ACTI_37240	COG1660	Displays ATPase and GTPase activities
ACTI_37260	COG1481	regulation of sporulation
ACTI_37270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACTI_37280	COG0126	phosphoglycerate kinase activity
ACTI_37290	COG0149	triose-phosphate isomerase activity
ACTI_37300	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACTI_37330	COG0363	glucosamine-6-phosphate deaminase activity
ACTI_37360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACTI_37380	COG0109	protoheme IX farnesyltransferase activity
ACTI_37410	COG1612	heme a metabolic process
ACTI_37460	COG0396	ATPase activity
ACTI_37470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACTI_37480	COG0822	iron-sulfur transferase activity
ACTI_37490	COG2151	metal-sulfur cluster biosynthetic enzyme
ACTI_37510	COG2267	carboxylic ester hydrolase activity
ACTI_37590	COG0488	(ABC) transporter
ACTI_37620	COG1132	(ABC) transporter
ACTI_37640	COG3663	DNA glycosylase
ACTI_37650	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_37700	COG1473	amidohydrolase
ACTI_37720	COG1674	ftsk spoiiie
ACTI_38020	COG1309	transcriptional regulator
ACTI_38100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACTI_38150	COG3903	Transcriptional regulator
ACTI_38150	COG3629	intracellular signal transduction
ACTI_38160	COG0006	proline dipeptidase activity
ACTI_38230	COG0714	Associated with various cellular activities
ACTI_38260	COG2197	response regulator
ACTI_38270	COG4585	Histidine kinase
ACTI_38280	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_38290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACTI_38380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACTI_38480	COG0745	RESPONSE REGULATOR receiver
ACTI_38490	COG2205	protein histidine kinase activity
ACTI_38510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACTI_38510	COG2111	Na H antiporter
ACTI_38550	COG2212	antiporter activity
ACTI_38560	COG1320	monovalent cation:proton antiporter activity
ACTI_38570	COG3328	transposase activity
ACTI_38630	COG1365	unkown
ACTI_38640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACTI_38680	COG1175	transmembrane transport
ACTI_38710	COG1175	transmembrane transport
ACTI_38770	COG4585	Histidine kinase
ACTI_38780	COG2197	response regulator
ACTI_38910	COG1215	transferase activity, transferring glycosyl groups
ACTI_38950	COG2261	transglycosylase associated protein
ACTI_38980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACTI_39010	COG1309	transcriptional regulator
ACTI_39040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACTI_39090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACTI_39100	COG0515	serine threonine protein kinase
ACTI_39150	COG2200	EAL domain
ACTI_39150	COG2203	Gaf domain
ACTI_39150	COG2199	diguanylate cyclase activity
ACTI_39170	COG1053	succinate dehydrogenase
ACTI_39180	COG1253	flavin adenine dinucleotide binding
ACTI_39200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACTI_39210	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACTI_39220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACTI_39240	COG3158	transport of potassium into the cell
ACTI_39270	COG0840	transmembrane signaling receptor activity
ACTI_39320	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_39360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACTI_39370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_39380	COG1116	anion transmembrane transporter activity
ACTI_39430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACTI_39430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACTI_39450	COG1175	transmembrane transport
ACTI_39460	COG1653	transport
ACTI_39480	COG4251	negative regulation of phosphorylation
ACTI_39500	COG1252	NADH dehydrogenase
ACTI_39520	COG5002	protein histidine kinase activity
ACTI_39530	COG2205	protein histidine kinase activity
ACTI_39540	COG2199	diguanylate cyclase activity
ACTI_39540	COG2203	Gaf domain
ACTI_39540	COG2200	EAL domain
ACTI_39560	COG5002	protein histidine kinase activity
ACTI_39570	COG4251	negative regulation of phosphorylation
ACTI_39580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACTI_39600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACTI_39630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACTI_39700	COG0628	permease
ACTI_39770	COG2197	response regulator
ACTI_39790	COG2197	response regulator
ACTI_39870	COG0477	Major facilitator Superfamily
ACTI_39940	COG2326	polyphosphate kinase activity
ACTI_39960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACTI_40010	COG1132	(ABC) transporter
ACTI_40020	COG1132	(ABC) transporter
ACTI_40030	COG2197	response regulator
ACTI_40060	COG0477	Major facilitator Superfamily
ACTI_40100	COG0531	amino acid
ACTI_40120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_40140	COG5002	protein histidine kinase activity
ACTI_40180	COG0489	protein tyrosine kinase activity
ACTI_40220	COG0745	RESPONSE REGULATOR receiver
ACTI_40300	COG2271	Major facilitator Superfamily
ACTI_40380	COG2755	lipolytic protein G-D-S-L family
ACTI_40400	COG0387	Pfam Sodium calcium exchanger
ACTI_40410	COG4106	trans-aconitate 2-methyltransferase activity
ACTI_40420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACTI_40430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACTI_40440	COG0019	diaminopimelate decarboxylase activity
ACTI_40470	COG0701	Predicted permease
ACTI_40520	COG0730	response to heat
ACTI_40580	COG2720	vancomycin resistance protein
ACTI_40600	COG5002	protein histidine kinase activity
ACTI_40600	COG2205	protein histidine kinase activity
ACTI_40600	COG0784	Response regulator, receiver
ACTI_40670	COG2197	response regulator
ACTI_40680	COG0366	Alpha amylase catalytic
ACTI_40720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACTI_40770	COG1215	transferase activity, transferring glycosyl groups
ACTI_40810	COG0641	radical SAM
ACTI_40850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACTI_40890	COG0297	glycogen (starch) synthase activity
ACTI_40910	COG4981	capsule polysaccharide biosynthetic process
ACTI_40930	COG0243	molybdopterin cofactor binding
ACTI_41000	COG4677	pectinesterase activity
ACTI_41030	COG1053	succinate dehydrogenase
ACTI_41050	COG1309	transcriptional regulator
ACTI_41060	COG1960	acyl-CoA dehydrogenase activity
ACTI_41070	COG1960	acyl-CoA dehydrogenase activity
ACTI_41110	COG2910	NAD(P)H-binding
ACTI_41130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACTI_41170	COG1053	succinate dehydrogenase
ACTI_41210	COG1960	acyl-CoA dehydrogenase activity
ACTI_41220	COG2267	carboxylic ester hydrolase activity
ACTI_41230	COG0346	lactoylglutathione lyase activity
ACTI_41240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACTI_41250	COG1960	acyl-CoA dehydrogenase activity
ACTI_41260	COG1960	acyl-CoA dehydrogenase activity
ACTI_41270	COG1960	acyl-CoA dehydrogenase activity
ACTI_41280	COG1024	Enoyl-CoA hydratase
ACTI_41290	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_41300	COG1960	acyl-CoA dehydrogenase activity
ACTI_41310	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_41340	COG0183	Belongs to the thiolase family
ACTI_41350	COG2124	cytochrome p450
ACTI_41360	COG3903	Transcriptional regulator
ACTI_41360	COG3629	intracellular signal transduction
ACTI_41440	COG1132	(ABC) transporter
ACTI_41450	COG2070	2-Nitropropane dioxygenase
ACTI_41500	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_41540	COG1960	acyl-CoA dehydrogenase activity
ACTI_41550	COG1960	acyl-CoA dehydrogenase activity
ACTI_41560	COG0183	Belongs to the thiolase family
ACTI_41610	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_41620	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_41640	COG1309	transcriptional regulator
ACTI_41690	COG1309	transcriptional regulator
ACTI_41700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACTI_41710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_41800	COG0667	Aldo Keto reductase
ACTI_41820	COG1131	(ABC) transporter
ACTI_41840	COG4585	Histidine kinase
ACTI_41850	COG2197	response regulator
ACTI_41960	COG3459	Glycosyltransferase 36 associated
ACTI_42060	COG3599	regulation of cell shape
ACTI_42090	COG0277	FAD linked oxidase domain protein
ACTI_42100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACTI_42120	COG1132	(ABC) transporter
ACTI_42130	COG1132	(ABC) transporter
ACTI_42170	COG1309	transcriptional regulator
ACTI_42210	COG1595	DNA-templated transcription, initiation
ACTI_42240	COG0840	transmembrane signaling receptor activity
ACTI_42310	COG0477	Major facilitator Superfamily
ACTI_42370	COG0697	spore germination
ACTI_42440	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACTI_42460	COG1070	Carbohydrate kinase
ACTI_42470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACTI_42500	COG5001	Diguanylate cyclase
ACTI_42550	COG3304	Inner membrane component domain
ACTI_42580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ACTI_42600	COG3033	Beta-eliminating lyase
ACTI_42710	COG2814	Major facilitator Superfamily
ACTI_42730	COG2890	protein-(glutamine-N5) methyltransferase activity
ACTI_42780	COG2235	arginine
ACTI_42800	COG3537	Alpha-1,2-mannosidase
ACTI_42820	COG4948	Mandelate Racemase Muconate Lactonizing
ACTI_42850	COG3842	ATPase activity
ACTI_42870	COG1609	Transcriptional regulator
ACTI_42920	COG0714	Associated with various cellular activities
ACTI_42930	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACTI_42970	COG1960	acyl-CoA dehydrogenase activity
ACTI_42990	COG1802	Transcriptional regulator
ACTI_43060	COG0243	molybdopterin cofactor binding
ACTI_43090	COG1136	(ABC) transporter
ACTI_43090	COG0577	efflux transmembrane transporter activity
ACTI_43100	COG1136	(ABC) transporter
ACTI_43130	COG0667	Aldo Keto reductase
ACTI_43150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACTI_43160	COG1309	transcriptional regulator
ACTI_43170	COG0488	(ABC) transporter
ACTI_43210	COG0697	spore germination
ACTI_43220	COG2357	RelA SpoT domain protein
ACTI_43250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_43270	COG2807	transmembrane transport
ACTI_43420	COG1554	hydrolase, family 65, central catalytic
ACTI_43530	COG0395	ABC-type sugar transport system, permease component
ACTI_43540	COG1175	transmembrane transport
ACTI_43560	COG4821	SIS domain
ACTI_43570	COG1737	Transcriptional regulator
ACTI_43640	COG3903	Transcriptional regulator
ACTI_43640	COG3629	intracellular signal transduction
ACTI_43700	COG0583	DNA-binding transcription factor activity
ACTI_43860	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_43890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACTI_43900	COG2409	Drug exporters of the RND superfamily
ACTI_43920	COG3940	Belongs to the glycosyl hydrolase 43 family
ACTI_43980	COG3866	Pectate lyase
ACTI_44030	COG0439	Biotin carboxylase
ACTI_44060	COG1253	flavin adenine dinucleotide binding
ACTI_44100	COG3876	Protein conserved in bacteria
ACTI_44110	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ACTI_44160	COG0583	DNA-binding transcription factor activity
ACTI_44230	COG2197	response regulator
ACTI_44240	COG4585	Histidine kinase
ACTI_44330	COG1309	transcriptional regulator
ACTI_44460	COG2197	response regulator
ACTI_44470	COG4585	Histidine kinase
ACTI_44480	COG2409	Drug exporters of the RND superfamily
ACTI_44520	COG1595	DNA-templated transcription, initiation
ACTI_44570	COG2409	Drug exporters of the RND superfamily
ACTI_44620	COG0604	alcohol dehydrogenase
ACTI_44640	COG1902	pentaerythritol trinitrate reductase activity
ACTI_44710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_44780	COG4974	Belongs to the 'phage' integrase family
ACTI_44830	COG0574	Belongs to the PEP-utilizing enzyme family
ACTI_44830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACTI_44930	COG0840	transmembrane signaling receptor activity
ACTI_44990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACTI_45060	COG0745	RESPONSE REGULATOR receiver
ACTI_45070	COG5002	protein histidine kinase activity
ACTI_45090	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACTI_45100	COG1278	Cold shock
ACTI_45140	COG0861	Integral membrane protein TerC family
ACTI_45150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_45200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACTI_45210	COG3290	protein histidine kinase activity
ACTI_45240	COG0475	glutathione-regulated potassium exporter activity
ACTI_45350	COG3903	Transcriptional regulator
ACTI_45350	COG3629	intracellular signal transduction
ACTI_45360	COG0165	Argininosuccinate lyase
ACTI_45370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACTI_45430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACTI_45490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ACTI_45590	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_45640	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_45660	COG0492	ferredoxin-NADP+ reductase activity
ACTI_45680	COG3384	dioxygenase
ACTI_45720	COG0604	alcohol dehydrogenase
ACTI_45760	COG4733	cellulase activity
ACTI_45760	COG5297	Belongs to the glycosyl hydrolase family 6
ACTI_45770	COG3693	PFAM glycoside hydrolase, family 10
ACTI_45830	COG2814	Major facilitator Superfamily
ACTI_45840	COG1940	carbohydrate kinase activity
ACTI_45860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_45880	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_45890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACTI_45900	COG1024	Enoyl-CoA hydratase
ACTI_45910	COG1414	Transcriptional regulator
ACTI_45930	COG3971	2-oxopent-4-enoate hydratase activity
ACTI_45940	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ACTI_46060	COG1131	(ABC) transporter
ACTI_46070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACTI_46130	COG4585	Histidine kinase
ACTI_46140	COG2197	response regulator
ACTI_46150	COG0577	efflux transmembrane transporter activity
ACTI_46150	COG1136	(ABC) transporter
ACTI_46180	COG1131	(ABC) transporter
ACTI_46210	COG2197	response regulator
ACTI_46230	COG3629	intracellular signal transduction
ACTI_46230	COG3903	Transcriptional regulator
ACTI_46260	COG0596	Alpha beta hydrolase
ACTI_46280	COG2197	response regulator
ACTI_46300	COG1131	(ABC) transporter
ACTI_46340	COG1982	Orn Lys Arg decarboxylase major
ACTI_46350	COG1733	regulation of RNA biosynthetic process
ACTI_46370	COG4221	oxidoreductase activity
ACTI_46400	COG4585	Histidine kinase
ACTI_46410	COG2197	response regulator
ACTI_46440	COG1609	Transcriptional regulator
ACTI_46470	COG0395	ABC-type sugar transport system, permease component
ACTI_46490	COG1609	Transcriptional regulator
ACTI_46560	COG2366	antibiotic biosynthetic process
ACTI_46570	COG0702	epimerase
ACTI_46580	COG1733	regulation of RNA biosynthetic process
ACTI_46600	COG0477	Major facilitator Superfamily
ACTI_46620	COG1653	transport
ACTI_46710	COG3328	transposase activity
ACTI_46780	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_46820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACTI_46840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACTI_46850	COG3237	CsbD-like
ACTI_46870	COG3328	transposase activity
ACTI_46950	COG0667	Aldo Keto reductase
ACTI_47010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACTI_47170	COG0438	transferase activity, transferring glycosyl groups
ACTI_47220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACTI_47220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACTI_47250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACTI_47260	COG0673	inositol 2-dehydrogenase activity
ACTI_47350	COG0589	response to stress
ACTI_47360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACTI_47380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACTI_47490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACTI_47530	COG3903	Transcriptional regulator
ACTI_47530	COG3629	intracellular signal transduction
ACTI_47560	COG0644	oxidoreductase
ACTI_47600	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_47650	COG0494	nUDIX hydrolase
ACTI_47790	COG1131	(ABC) transporter
ACTI_47820	COG1316	TRANSCRIPTIONal
ACTI_47830	COG0840	transmembrane signaling receptor activity
ACTI_47880	COG0569	domain protein
ACTI_47900	COG2130	NADP-dependent
ACTI_47940	COG0235	Class ii aldolase
ACTI_47960	COG1609	Transcriptional regulator
ACTI_47970	COG1879	ABC-type sugar transport system periplasmic component
ACTI_47990	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACTI_48000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACTI_48010	COG2160	L-arabinose isomerase activity
ACTI_48040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ACTI_48100	COG2409	Drug exporters of the RND superfamily
ACTI_48150	COG0640	Transcriptional regulator
ACTI_48200	COG0395	ABC-type sugar transport system, permease component
ACTI_48270	COG1017	nitric oxide dioxygenase activity
ACTI_48270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACTI_48290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_48310	COG1116	anion transmembrane transporter activity
ACTI_48350	COG0477	Major facilitator Superfamily
ACTI_48410	COG1486	melibiose metabolic process
ACTI_48470	COG4585	Histidine kinase
ACTI_48480	COG2197	response regulator
ACTI_48490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACTI_48500	COG2011	ABC-type metal ion transport system permease component
ACTI_48510	COG1464	Belongs to the NlpA lipoprotein family
ACTI_48540	COG0686	Belongs to the AlaDH PNT family
ACTI_48610	COG2226	methyltransferase
ACTI_48660	COG1902	pentaerythritol trinitrate reductase activity
ACTI_48670	COG2814	Major facilitator Superfamily
ACTI_48680	COG1609	Transcriptional regulator
ACTI_48700	COG1122	ATPase activity
ACTI_48720	COG4721	ABC-type cobalt transport system, permease component
ACTI_48740	COG0542	response to heat
ACTI_48770	COG3903	Transcriptional regulator
ACTI_48770	COG3629	intracellular signal transduction
ACTI_48780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACTI_48850	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACTI_48880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACTI_48890	COG1309	transcriptional regulator
ACTI_49040	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACTI_49050	COG0028	Belongs to the TPP enzyme family
ACTI_49060	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ACTI_49100	COG3360	Dodecin
ACTI_49110	COG4251	negative regulation of phosphorylation
ACTI_49110	COG5001	Diguanylate cyclase
ACTI_49110	COG3706	GGDEF domain
ACTI_49110	COG2203	Gaf domain
ACTI_49250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_49270	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ACTI_49310	COG0596	Alpha beta hydrolase
ACTI_49340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACTI_49350	COG1024	Enoyl-CoA hydratase
ACTI_49370	COG1595	DNA-templated transcription, initiation
ACTI_49420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_49430	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_49440	COG1120	ATPase activity
ACTI_49450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACTI_49460	COG2200	EAL domain
ACTI_49460	COG2199	diguanylate cyclase activity
ACTI_49460	COG3287	FIST C domain
ACTI_49670	COG2197	response regulator
ACTI_49690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACTI_49700	COG1595	DNA-templated transcription, initiation
ACTI_50010	COG0596	Alpha beta hydrolase
ACTI_50040	COG1414	Transcriptional regulator
ACTI_50060	COG2124	cytochrome p450
ACTI_50080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACTI_50110	COG1609	Transcriptional regulator
ACTI_50150	COG0395	ABC-type sugar transport system, permease component
ACTI_50170	COG1609	Transcriptional regulator
ACTI_50180	COG0477	Major facilitator Superfamily
ACTI_50220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACTI_50230	COG0778	Nitroreductase
ACTI_50540	COG1902	pentaerythritol trinitrate reductase activity
ACTI_50550	COG3480	Lon protease (S16) C-terminal proteolytic domain
ACTI_50600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACTI_50600	COG0515	serine threonine protein kinase
ACTI_50650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACTI_50660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACTI_50690	COG0765	amino acid transport
ACTI_50760	COG1595	DNA-templated transcription, initiation
ACTI_50850	COG3345	alpha-galactosidase
ACTI_50860	COG3507	Belongs to the glycosyl hydrolase 43 family
ACTI_50880	COG3693	PFAM glycoside hydrolase, family 10
ACTI_50960	COG0702	epimerase
ACTI_51020	COG3706	GGDEF domain
ACTI_51030	COG1309	transcriptional regulator
ACTI_51060	COG2197	response regulator
ACTI_51080	COG4608	Belongs to the ABC transporter superfamily
ACTI_51090	COG0444	Belongs to the ABC transporter superfamily
ACTI_51120	COG0747	negative chemotaxis
ACTI_51160	COG1609	Transcriptional regulator
ACTI_51180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACTI_51190	COG1653	transport
ACTI_51210	COG0395	ABC-type sugar transport system, permease component
ACTI_51270	COG3046	protein related to deoxyribodipyrimidine photolyase
ACTI_51280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_51280	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACTI_51300	COG0395	ABC-type sugar transport system, permease component
ACTI_51310	COG1175	transmembrane transport
ACTI_51320	COG1653	transport
ACTI_51360	COG2814	Major facilitator Superfamily
ACTI_51420	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_51430	COG1960	acyl-CoA dehydrogenase activity
ACTI_51520	COG1653	transport
ACTI_51530	COG1175	transmembrane transport
ACTI_51540	COG0395	ABC-type sugar transport system, permease component
ACTI_51560	COG3842	ATPase activity
ACTI_51570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACTI_51740	COG2223	nitrite transmembrane transporter activity
ACTI_51760	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_51810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACTI_51830	COG0183	Belongs to the thiolase family
ACTI_51870	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_51880	COG1960	acyl-CoA dehydrogenase activity
ACTI_51890	COG1960	acyl-CoA dehydrogenase activity
ACTI_51930	COG0477	Major facilitator Superfamily
ACTI_51960	COG1271	oxidase subunit
ACTI_51970	COG1252	NADH dehydrogenase
ACTI_51990	COG0494	nUDIX hydrolase
ACTI_52020	COG2340	Cysteine-rich secretory protein family
ACTI_52030	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_52060	COG0243	molybdopterin cofactor binding
ACTI_52100	COG0142	geranyltranstransferase activity
ACTI_52140	COG1131	(ABC) transporter
ACTI_52150	COG4585	Histidine kinase
ACTI_52160	COG2197	response regulator
ACTI_52200	COG1733	regulation of RNA biosynthetic process
ACTI_52250	COG0745	RESPONSE REGULATOR receiver
ACTI_52260	COG2205	protein histidine kinase activity
ACTI_52280	COG1228	amidohydrolase
ACTI_52290	COG1278	Cold shock
ACTI_52320	COG4941	Belongs to the sigma-70 factor family
ACTI_52350	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACTI_52350	COG1672	PFAM Archaeal ATPase
ACTI_52380	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACTI_52390	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACTI_52410	COG1414	Transcriptional regulator
ACTI_52420	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_52430	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_52440	COG2211	Major facilitator Superfamily
ACTI_52450	COG1228	amidohydrolase
ACTI_52540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_52610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACTI_52630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACTI_52680	COG0583	DNA-binding transcription factor activity
ACTI_52770	COG1595	DNA-templated transcription, initiation
ACTI_52810	COG0640	Transcriptional regulator
ACTI_52900	COG0583	DNA-binding transcription factor activity
ACTI_52980	COG1132	(ABC) transporter
ACTI_52990	COG1132	(ABC) transporter
ACTI_53020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_53030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_53040	COG1120	ATPase activity
ACTI_53100	COG0596	Alpha beta hydrolase
ACTI_53170	COG4585	Histidine kinase
ACTI_53190	COG0697	spore germination
ACTI_53200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACTI_53210	COG1595	DNA-templated transcription, initiation
ACTI_53290	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACTI_53300	COG0039	L-malate dehydrogenase activity
ACTI_53360	COG3291	Pkd domain containing protein
ACTI_53400	COG0840	transmembrane signaling receptor activity
ACTI_53410	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACTI_53440	COG1522	sequence-specific DNA binding
ACTI_53460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACTI_53570	COG3559	Exporter of polyketide antibiotics
ACTI_53620	COG0494	nUDIX hydrolase
ACTI_53660	COG2814	Major facilitator Superfamily
ACTI_53680	COG1595	DNA-templated transcription, initiation
ACTI_53750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_53770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACTI_53780	COG5001	Diguanylate cyclase
ACTI_53780	COG3300	MHYT domain
ACTI_53790	COG3537	Alpha-1,2-mannosidase
ACTI_53850	COG2365	Tyrosine phosphatase family
ACTI_53860	COG2815	serine threonine protein kinase
ACTI_53860	COG0515	serine threonine protein kinase
ACTI_54040	COG0765	amino acid transport
ACTI_54050	COG1126	abc transporter atp-binding protein
ACTI_54110	COG0154	amidase activity
ACTI_54140	COG2186	Transcriptional regulator
ACTI_54150	COG1609	Transcriptional regulator
ACTI_54230	COG0667	Aldo Keto reductase
ACTI_54250	COG0346	lactoylglutathione lyase activity
ACTI_54290	COG0477	Major facilitator Superfamily
ACTI_54300	COG3226	Transcriptional regulator
ACTI_54320	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_54320	COG3347	Dehydrogenase
ACTI_54330	COG1070	Carbohydrate kinase
ACTI_54340	COG0247	lactate metabolic process
ACTI_54350	COG1139	Iron-sulfur cluster binding protein
ACTI_54360	COG1556	Lactate utilization protein
ACTI_54410	COG0745	RESPONSE REGULATOR receiver
ACTI_54460	COG0577	efflux transmembrane transporter activity
ACTI_54460	COG1136	(ABC) transporter
ACTI_54470	COG0577	efflux transmembrane transporter activity
ACTI_54470	COG1136	(ABC) transporter
ACTI_54500	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACTI_54520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_54550	COG4948	Mandelate Racemase Muconate Lactonizing
ACTI_54590	COG1191	sigma factor activity
ACTI_54650	COG0531	amino acid
ACTI_54730	COG1116	anion transmembrane transporter activity
ACTI_54740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_54750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_54770	COG1414	Transcriptional regulator
ACTI_54780	COG5001	Diguanylate cyclase
ACTI_54780	COG3300	MHYT domain
ACTI_54900	COG4176	ABC-type proline glycine betaine transport system permease component
ACTI_54910	COG4175	Glycine betaine
ACTI_54910	COG0517	IMP dehydrogenase activity
ACTI_54940	COG2146	nitrite reductase [NAD(P)H] activity
ACTI_54980	COG4638	Rieske (2fe-2S)
ACTI_55140	COG1414	Transcriptional regulator
ACTI_55150	COG3485	protocatechuate 3,4-dioxygenase
ACTI_55160	COG3485	protocatechuate 3,4-dioxygenase
ACTI_55180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACTI_55250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_55270	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACTI_55300	COG2409	Drug exporters of the RND superfamily
ACTI_55440	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ACTI_55470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACTI_55650	COG1396	sequence-specific DNA binding
ACTI_55700	COG1960	acyl-CoA dehydrogenase activity
ACTI_55720	COG1960	acyl-CoA dehydrogenase activity
ACTI_55770	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACTI_55780	COG1472	Belongs to the glycosyl hydrolase 3 family
ACTI_55790	COG1609	Transcriptional regulator
ACTI_55820	COG0395	ABC-type sugar transport system, permease component
ACTI_55830	COG1501	Belongs to the glycosyl hydrolase 31 family
ACTI_55890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACTI_55900	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACTI_55930	COG1122	ATPase activity
ACTI_55960	COG0310	cobalt ion transport
ACTI_56030	COG5002	protein histidine kinase activity
ACTI_56040	COG2204	response regulator
ACTI_56060	COG4952	isomerase
ACTI_56070	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACTI_56090	COG1129	ABC transporter
ACTI_56100	COG1879	ABC-type sugar transport system periplasmic component
ACTI_56140	COG2815	serine threonine protein kinase
ACTI_56140	COG0515	serine threonine protein kinase
ACTI_56160	COG0436	Aminotransferase
ACTI_56180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACTI_56190	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_56200	COG3842	ATPase activity
ACTI_56220	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACTI_56230	COG1177	transmembrane transport
ACTI_56240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACTI_56270	COG5002	protein histidine kinase activity
ACTI_56270	COG0784	Response regulator, receiver
ACTI_56270	COG2198	Histidine kinase
ACTI_56280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACTI_56290	COG1522	sequence-specific DNA binding
ACTI_56300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACTI_56310	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_56320	COG2208	phosphoserine phosphatase activity
ACTI_56350	COG1175	transmembrane transport
ACTI_56390	COG0248	Ppx GppA phosphatase
ACTI_56400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACTI_56450	COG3191	aminopeptidase activity
ACTI_56480	COG0442	prolyl-tRNA aminoacylation
ACTI_56490	COG0702	epimerase
ACTI_56500	COG1733	regulation of RNA biosynthetic process
ACTI_56520	COG0840	transmembrane signaling receptor activity
ACTI_56530	COG5001	Diguanylate cyclase
ACTI_56540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACTI_56580	COG0747	negative chemotaxis
ACTI_56640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_56650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_56720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_56730	COG4521	taurine ABC transporter
ACTI_56740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ACTI_56790	COG0366	Alpha amylase catalytic
ACTI_56800	COG1609	Transcriptional regulator
ACTI_56830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_56840	COG2409	Drug exporters of the RND superfamily
ACTI_56860	COG1132	(ABC) transporter
ACTI_56900	COG0778	Nitroreductase
ACTI_56920	COG0372	Belongs to the citrate synthase family
ACTI_56950	COG0596	Alpha beta hydrolase
ACTI_56950	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACTI_57040	COG0243	molybdopterin cofactor binding
ACTI_57050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACTI_57070	COG2223	nitrite transmembrane transporter activity
ACTI_57130	COG1609	Transcriptional regulator
ACTI_57140	COG2223	nitrite transmembrane transporter activity
ACTI_57180	COG1136	(ABC) transporter
ACTI_57180	COG0577	efflux transmembrane transporter activity
ACTI_57190	COG0577	efflux transmembrane transporter activity
ACTI_57190	COG1136	(ABC) transporter
ACTI_57210	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_57230	COG0300	oxidoreductase activity
ACTI_57300	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_57390	COG4191	Histidine kinase
ACTI_57410	COG1448	Aminotransferase
ACTI_57470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACTI_57480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACTI_57490	COG2080	2 iron, 2 sulfur cluster binding
ACTI_57570	COG0601	transmembrane transport
ACTI_57580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACTI_57700	COG0583	DNA-binding transcription factor activity
ACTI_57740	COG1228	amidohydrolase
ACTI_57780	COG4952	isomerase
ACTI_57850	COG0706	membrane insertase activity
ACTI_57860	COG2814	Major facilitator Superfamily
ACTI_57900	COG0670	Belongs to the BI1 family
ACTI_57910	COG2267	carboxylic ester hydrolase activity
ACTI_57930	COG1435	thymidine kinase activity
ACTI_57970	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_58030	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACTI_58040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACTI_58060	COG1335	isochorismatase
ACTI_58080	COG0840	transmembrane signaling receptor activity
ACTI_58120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACTI_58130	COG0583	DNA-binding transcription factor activity
ACTI_58140	COG2814	Major facilitator Superfamily
ACTI_58160	COG4941	Belongs to the sigma-70 factor family
ACTI_58190	COG0604	alcohol dehydrogenase
ACTI_58210	COG5001	Diguanylate cyclase
ACTI_58240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_58320	COG1024	Enoyl-CoA hydratase
ACTI_58340	COG0738	Major facilitator superfamily
ACTI_58390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACTI_58400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ACTI_58420	COG0667	Aldo Keto reductase
ACTI_58460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_58500	COG3848	Pyruvate phosphate dikinase
ACTI_58500	COG0574	Belongs to the PEP-utilizing enzyme family
ACTI_58510	COG1309	transcriptional regulator
ACTI_58560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_58570	COG3708	Transcriptional regulator
ACTI_58570	COG2207	Transcriptional regulator
ACTI_58580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACTI_58600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACTI_58640	COG2197	response regulator
ACTI_58670	COG3507	Belongs to the glycosyl hydrolase 43 family
ACTI_58690	COG0542	response to heat
ACTI_58740	COG4251	negative regulation of phosphorylation
ACTI_58750	COG0745	RESPONSE REGULATOR receiver
ACTI_58760	COG2770	Histidine kinase
ACTI_58760	COG2208	phosphoserine phosphatase activity
ACTI_58800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACTI_58830	COG1051	belongs to the nudix hydrolase family
ACTI_58910	COG1063	alcohol dehydrogenase
ACTI_58950	COG3940	Belongs to the glycosyl hydrolase 43 family
ACTI_58990	COG0596	Alpha beta hydrolase
ACTI_59080	COG1404	Belongs to the peptidase S8 family
ACTI_59090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACTI_59120	COG4122	O-methyltransferase activity
ACTI_59130	COG0463	Glycosyl transferase, family 2
ACTI_59130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ACTI_59160	COG0667	Aldo Keto reductase
ACTI_59190	COG2197	response regulator
ACTI_59210	COG1396	sequence-specific DNA binding
ACTI_59220	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACTI_59250	COG2226	methyltransferase
ACTI_59330	COG1846	Transcriptional regulator
ACTI_59500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACTI_59510	COG0402	S-adenosylhomocysteine deaminase activity
ACTI_59550	COG1408	metallophosphoesterase
ACTI_59670	COG5002	protein histidine kinase activity
ACTI_59700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACTI_59750	COG5002	protein histidine kinase activity
ACTI_59770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACTI_59790	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACTI_59800	COG1121	(ABC) transporter
ACTI_59810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACTI_59830	COG0640	Transcriptional regulator
ACTI_59840	COG2072	flavoprotein involved in K transport
ACTI_59880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACTI_59890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACTI_59910	COG4941	Belongs to the sigma-70 factor family
ACTI_59920	COG3795	YCII-related domain
ACTI_59940	COG1064	alcohol dehydrogenase
ACTI_59950	COG0840	transmembrane signaling receptor activity
ACTI_59960	COG3507	Belongs to the glycosyl hydrolase 43 family
ACTI_59970	COG2197	response regulator
ACTI_59980	COG4585	Histidine kinase
ACTI_60150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACTI_60160	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_60190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_60210	COG1832	CoA-binding protein
ACTI_60230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACTI_60250	COG2072	flavoprotein involved in K transport
ACTI_60260	COG2205	protein histidine kinase activity
ACTI_60270	COG0745	RESPONSE REGULATOR receiver
ACTI_60290	COG2072	flavoprotein involved in K transport
ACTI_60300	COG1733	regulation of RNA biosynthetic process
ACTI_60480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ACTI_60540	COG1222	aaa ATPase
ACTI_60790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACTI_60800	COG0438	transferase activity, transferring glycosyl groups
ACTI_60810	COG2267	carboxylic ester hydrolase activity
ACTI_60870	COG0477	Major facilitator Superfamily
ACTI_60930	COG3447	MASE1 domain protein
ACTI_60930	COG5002	protein histidine kinase activity
ACTI_60930	COG5001	Diguanylate cyclase
ACTI_60950	COG2268	Band 7 protein
ACTI_60980	COG1846	Transcriptional regulator
ACTI_60990	COG2814	Major facilitator Superfamily
ACTI_61050	COG0110	maltose O-acetyltransferase activity
ACTI_61180	COG5001	Diguanylate cyclase
ACTI_61240	COG2197	response regulator
ACTI_61250	COG4585	Histidine kinase
ACTI_61260	COG3940	Belongs to the glycosyl hydrolase 43 family
ACTI_61280	COG0300	oxidoreductase activity
ACTI_61310	COG1136	(ABC) transporter
ACTI_61310	COG0577	efflux transmembrane transporter activity
ACTI_61340	COG1476	TRANSCRIPTIONal
ACTI_61350	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_61350	COG0604	alcohol dehydrogenase
ACTI_61350	COG3321	synthase
ACTI_61360	COG1960	acyl-CoA dehydrogenase activity
ACTI_61390	COG3300	MHYT domain
ACTI_61390	COG5001	Diguanylate cyclase
ACTI_61430	COG0745	RESPONSE REGULATOR receiver
ACTI_61440	COG2205	protein histidine kinase activity
ACTI_61460	COG2197	response regulator
ACTI_61480	COG1940	carbohydrate kinase activity
ACTI_61490	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACTI_61550	COG1940	carbohydrate kinase activity
ACTI_61600	COG0596	Alpha beta hydrolase
ACTI_61650	COG0784	Response regulator, receiver
ACTI_61690	COG0714	Associated with various cellular activities
ACTI_61710	COG0596	Alpha beta hydrolase
ACTI_61730	COG0531	amino acid
ACTI_61760	COG0640	Transcriptional regulator
ACTI_61800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACTI_61820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACTI_61840	COG0204	Acyl-transferase
ACTI_61880	COG2197	response regulator
ACTI_61890	COG0563	adenylate kinase activity
ACTI_61900	COG0254	rRNA binding
ACTI_61920	COG2124	cytochrome p450
ACTI_61950	COG1131	(ABC) transporter
ACTI_61960	COG4585	Histidine kinase
ACTI_61970	COG2197	response regulator
ACTI_61980	COG5297	Belongs to the glycosyl hydrolase family 6
ACTI_61990	COG5006	permease, DMT superfamily
ACTI_62000	COG0583	DNA-binding transcription factor activity
ACTI_62110	COG0726	polysaccharide deacetylase
ACTI_62130	COG5002	protein histidine kinase activity
ACTI_62160	COG1595	DNA-templated transcription, initiation
ACTI_62230	COG1132	(ABC) transporter
ACTI_62240	COG1132	(ABC) transporter
ACTI_62290	COG1960	acyl-CoA dehydrogenase activity
ACTI_62300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_62340	COG0277	FAD linked oxidase domain protein
ACTI_62450	COG0583	DNA-binding transcription factor activity
ACTI_62460	COG5006	permease, DMT superfamily
ACTI_62540	COG0789	Transcriptional regulator
ACTI_62550	COG4974	Belongs to the 'phage' integrase family
ACTI_62590	COG0443	Heat shock 70 kDa protein
ACTI_62600	COG2354	Protein conserved in bacteria
ACTI_62650	COG0583	DNA-binding transcription factor activity
ACTI_62660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACTI_62750	COG1131	(ABC) transporter
ACTI_62760	COG0842	Transport permease protein
ACTI_62770	COG4585	Histidine kinase
ACTI_62780	COG2197	response regulator
ACTI_62790	COG1191	sigma factor activity
ACTI_62800	COG0488	(ABC) transporter
ACTI_62810	COG1968	undecaprenyl-diphosphatase activity
ACTI_62880	COG2270	Major facilitator Superfamily
ACTI_62920	COG2197	response regulator
ACTI_62960	COG1846	Transcriptional regulator
ACTI_62960	COG0456	acetyltransferase
ACTI_63000	COG2814	Major facilitator Superfamily
ACTI_63030	COG2076	Multidrug Resistance protein
ACTI_63080	COG1846	Transcriptional regulator
ACTI_63160	COG1764	response to oxidative stress
ACTI_63170	COG1846	Transcriptional regulator
ACTI_63210	COG4702	Belongs to the UPF0303 family
ACTI_63260	COG1309	transcriptional regulator
ACTI_63320	COG0019	diaminopimelate decarboxylase activity
ACTI_63360	COG0488	(ABC) transporter
ACTI_63380	COG0667	Aldo Keto reductase
ACTI_63430	COG0242	peptide deformylase activity
ACTI_63450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACTI_63470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACTI_63470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACTI_63480	COG0667	Aldo Keto reductase
ACTI_63540	COG5001	Diguanylate cyclase
ACTI_63560	COG1960	acyl-CoA dehydrogenase activity
ACTI_63580	COG1024	Enoyl-CoA hydratase
ACTI_63590	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_63600	COG3599	regulation of cell shape
ACTI_63620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACTI_63670	COG0346	lactoylglutathione lyase activity
ACTI_63680	COG0640	Transcriptional regulator
ACTI_63750	COG0596	Alpha beta hydrolase
ACTI_63750	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACTI_63790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACTI_63830	COG0840	transmembrane signaling receptor activity
ACTI_63840	COG5002	protein histidine kinase activity
ACTI_63880	COG1473	amidohydrolase
ACTI_63910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_63980	COG1846	Transcriptional regulator
ACTI_64000	COG0659	secondary active sulfate transmembrane transporter activity
ACTI_64010	COG0789	Transcriptional regulator
ACTI_64060	COG1902	pentaerythritol trinitrate reductase activity
ACTI_64110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACTI_64120	COG1121	(ABC) transporter
ACTI_64160	COG0697	spore germination
ACTI_64170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACTI_64200	COG2376	Dihydroxyacetone kinase
ACTI_64220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACTI_64270	COG1695	Transcriptional regulator
ACTI_64310	COG3485	protocatechuate 3,4-dioxygenase
ACTI_64320	COG1454	alcohol dehydrogenase
ACTI_64330	COG0583	DNA-binding transcription factor activity
ACTI_64340	COG0183	Belongs to the thiolase family
ACTI_64360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACTI_64420	COG1846	Transcriptional regulator
ACTI_64460	COG1940	carbohydrate kinase activity
ACTI_64510	COG0673	inositol 2-dehydrogenase activity
ACTI_64530	COG2226	methyltransferase
ACTI_64550	COG0667	Aldo Keto reductase
ACTI_64560	COG0640	Transcriptional regulator
ACTI_64680	COG2226	methyltransferase
ACTI_64700	COG1309	transcriptional regulator
ACTI_64710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACTI_64720	COG0438	transferase activity, transferring glycosyl groups
ACTI_64790	COG1082	Xylose isomerase domain protein TIM barrel
ACTI_64800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACTI_64840	COG0840	transmembrane signaling receptor activity
ACTI_64890	COG1733	regulation of RNA biosynthetic process
ACTI_64960	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACTI_65000	COG4221	oxidoreductase activity
ACTI_65040	COG2197	response regulator
ACTI_65080	COG2356	endonuclease I
ACTI_65130	COG0778	Nitroreductase
ACTI_65150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACTI_65180	COG1309	transcriptional regulator
ACTI_65190	COG4221	oxidoreductase activity
ACTI_65210	COG2197	response regulator
ACTI_65220	COG0110	maltose O-acetyltransferase activity
ACTI_65270	COG2837	iron assimilation
ACTI_65290	COG0494	nUDIX hydrolase
ACTI_65350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACTI_65360	COG2197	response regulator
ACTI_65370	COG4585	Histidine kinase
ACTI_65420	COG0443	Heat shock 70 kDa protein
ACTI_65450	COG0596	Alpha beta hydrolase
ACTI_65490	COG0247	lactate metabolic process
ACTI_65490	COG0277	FAD linked oxidase domain protein
ACTI_65600	COG0596	Alpha beta hydrolase
ACTI_65630	COG1595	DNA-templated transcription, initiation
ACTI_65660	COG2226	methyltransferase
ACTI_65690	COG2072	flavoprotein involved in K transport
ACTI_65710	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACTI_65710	COG1902	pentaerythritol trinitrate reductase activity
ACTI_65800	COG0765	amino acid transport
ACTI_65810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACTI_65820	COG2815	serine threonine protein kinase
ACTI_65820	COG0515	serine threonine protein kinase
ACTI_65840	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_65890	COG2070	2-Nitropropane dioxygenase
ACTI_66150	COG0492	ferredoxin-NADP+ reductase activity
ACTI_66190	COG2909	trisaccharide binding
ACTI_66210	COG0277	FAD linked oxidase domain protein
ACTI_66220	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_66240	COG1335	isochorismatase
ACTI_66260	COG1024	Enoyl-CoA hydratase
ACTI_66290	COG2200	EAL domain
ACTI_66310	COG0640	Transcriptional regulator
ACTI_66320	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_66370	COG1940	carbohydrate kinase activity
ACTI_66380	COG2814	Major facilitator Superfamily
ACTI_66390	COG3300	MHYT domain
ACTI_66390	COG5001	Diguanylate cyclase
ACTI_66420	COG0730	response to heat
ACTI_66440	COG5006	permease, DMT superfamily
ACTI_66450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACTI_66460	COG3300	MHYT domain
ACTI_66460	COG5001	Diguanylate cyclase
ACTI_66470	COG3300	MHYT domain
ACTI_66470	COG5001	Diguanylate cyclase
ACTI_66600	COG1742	UPF0060 membrane protein
ACTI_66620	COG0300	oxidoreductase activity
ACTI_66650	COG0402	S-adenosylhomocysteine deaminase activity
ACTI_66710	COG4585	Histidine kinase
ACTI_66720	COG2197	response regulator
ACTI_66820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACTI_66870	COG0405	Gamma-glutamyltransferase
ACTI_66890	COG3619	membrane
ACTI_66940	COG1090	epimerase
ACTI_66970	COG1404	Belongs to the peptidase S8 family
ACTI_66990	COG1672	PFAM Archaeal ATPase
ACTI_66990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACTI_67150	COG5002	protein histidine kinase activity
ACTI_67150	COG5001	Diguanylate cyclase
ACTI_67150	COG3447	MASE1 domain protein
ACTI_67160	COG3401	FG-GAP repeat protein
ACTI_67180	COG1309	transcriptional regulator
ACTI_67200	COG0783	Belongs to the Dps family
ACTI_67210	COG1228	amidohydrolase
ACTI_67250	COG1309	transcriptional regulator
ACTI_67270	COG1760	l-serine dehydratase
ACTI_67280	COG1597	lipid kinase activity
ACTI_67290	COG0129	dihydroxy-acid dehydratase activity
ACTI_67300	COG0583	DNA-binding transcription factor activity
ACTI_67310	COG1024	Enoyl-CoA hydratase
ACTI_67320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACTI_67350	COG1309	transcriptional regulator
ACTI_67410	COG1073	alpha beta
ACTI_67480	COG2814	Major facilitator Superfamily
ACTI_67510	COG2409	Drug exporters of the RND superfamily
ACTI_67540	COG0840	transmembrane signaling receptor activity
ACTI_67550	COG0129	dihydroxy-acid dehydratase activity
ACTI_67590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACTI_67600	COG0840	transmembrane signaling receptor activity
ACTI_67610	COG4941	Belongs to the sigma-70 factor family
ACTI_67750	COG1131	(ABC) transporter
ACTI_67840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACTI_67910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ACTI_68070	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACTI_68080	COG1129	ABC transporter
ACTI_68140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACTI_68230	COG1063	alcohol dehydrogenase
ACTI_68340	COG0529	Catalyzes the synthesis of activated sulfate
ACTI_68490	COG4221	oxidoreductase activity
ACTI_68510	COG0069	glutamate synthase activity
ACTI_68530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACTI_68550	COG0670	Belongs to the BI1 family
ACTI_68650	COG2272	Belongs to the type-B carboxylesterase lipase family
ACTI_68720	COG1609	Transcriptional regulator
ACTI_68750	COG2226	methyltransferase
ACTI_68760	COG3135	benzoate transporter
ACTI_68890	COG2423	ornithine cyclodeaminase activity
ACTI_68940	COG4608	Belongs to the ABC transporter superfamily
ACTI_68960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACTI_69030	COG0702	epimerase
ACTI_69040	COG1733	regulation of RNA biosynthetic process
ACTI_69120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACTI_69130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACTI_69140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACTI_69180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACTI_69200	COG0028	Belongs to the TPP enzyme family
ACTI_69210	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_69220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACTI_69330	COG0747	negative chemotaxis
ACTI_69370	COG4608	Belongs to the ABC transporter superfamily
ACTI_69450	COG1309	transcriptional regulator
ACTI_69510	COG1309	transcriptional regulator
ACTI_69540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACTI_69550	COG1737	Transcriptional regulator
ACTI_69580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACTI_69590	COG0601	transmembrane transport
ACTI_69620	COG1720	tRNA m6t6A37 methyltransferase activity
ACTI_69660	COG3387	PFAM Glycoside hydrolase 15-related
ACTI_69720	COG0697	spore germination
ACTI_69730	COG2815	serine threonine protein kinase
ACTI_69730	COG0515	serine threonine protein kinase
ACTI_69770	COG0242	peptide deformylase activity
ACTI_69840	COG2837	iron assimilation
ACTI_69930	COG0640	Transcriptional regulator
ACTI_69970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACTI_70000	COG3848	Pyruvate phosphate dikinase
ACTI_70000	COG0574	Belongs to the PEP-utilizing enzyme family
ACTI_70020	COG4941	Belongs to the sigma-70 factor family
ACTI_70030	COG3795	YCII-related domain
ACTI_70110	COG4585	Histidine kinase
ACTI_70130	COG1131	(ABC) transporter
ACTI_70190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACTI_70200	COG0800	Aldolase
ACTI_70210	COG0246	Mannitol dehydrogenase
ACTI_70230	COG2721	sulfolactate sulfo-lyase activity
ACTI_70270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ACTI_70280	COG1725	Transcriptional regulator
ACTI_70400	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ACTI_70410	COG0076	glutamate decarboxylase activity
ACTI_70450	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACTI_70460	COG1733	regulation of RNA biosynthetic process
ACTI_70520	COG0789	Transcriptional regulator
ACTI_70520	COG4978	Transcriptional regulator
ACTI_70530	COG1760	l-serine dehydratase
ACTI_70540	COG0509	glycine decarboxylation via glycine cleavage system
ACTI_70550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACTI_70560	COG2205	protein histidine kinase activity
ACTI_70770	COG0667	Aldo Keto reductase
ACTI_70810	COG0463	Glycosyl transferase, family 2
ACTI_70830	COG3973	AAA domain
ACTI_70880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACTI_70890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACTI_70910	COG0604	alcohol dehydrogenase
ACTI_70920	COG1509	lysine 2,3-aminomutase activity
ACTI_70960	COG0583	DNA-binding transcription factor activity
ACTI_70980	COG0456	acetyltransferase
ACTI_71000	COG1960	acyl-CoA dehydrogenase activity
ACTI_71010	COG2197	response regulator
ACTI_71020	COG4585	Histidine kinase
ACTI_71030	COG1136	(ABC) transporter
ACTI_71050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACTI_71060	COG5001	Diguanylate cyclase
ACTI_71060	COG1716	ATPase activity
ACTI_71100	COG3706	GGDEF domain
ACTI_71140	COG2223	nitrite transmembrane transporter activity
ACTI_71150	COG5002	protein histidine kinase activity
ACTI_71150	COG5001	Diguanylate cyclase
ACTI_71150	COG3447	MASE1 domain protein
ACTI_71170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACTI_71300	COG1621	beta-fructofuranosidase activity
ACTI_71330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACTI_71340	COG2197	response regulator
ACTI_71360	COG0667	Aldo Keto reductase
ACTI_71370	COG0789	Transcriptional regulator
ACTI_71480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ACTI_71500	COG5001	Diguanylate cyclase
ACTI_71530	COG3022	response to hydroperoxide
ACTI_71540	COG0545	Peptidyl-prolyl cis-trans isomerase
ACTI_71590	COG0706	membrane insertase activity
ACTI_71610	COG4279	zinc finger
ACTI_71620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACTI_71670	COG2124	cytochrome p450
ACTI_71700	COG0531	amino acid
ACTI_71720	COG0515	serine threonine protein kinase
ACTI_71770	COG1072	(Pantothenic acid kinase))
ACTI_71780	COG1408	metallophosphoesterase
ACTI_71820	COG1132	(ABC) transporter
ACTI_71830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACTI_71880	COG3328	transposase activity
ACTI_71890	COG0596	Alpha beta hydrolase
ACTI_71900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACTI_71910	COG2151	metal-sulfur cluster biosynthetic enzyme
ACTI_71920	COG3396	Phenylacetate-CoA oxygenase
ACTI_71930	COG3460	Phenylacetate-CoA oxygenase
ACTI_71940	COG3396	Phenylacetate-CoA oxygenase
ACTI_71960	COG1309	transcriptional regulator
ACTI_71980	COG0673	inositol 2-dehydrogenase activity
ACTI_72050	COG3962	Belongs to the TPP enzyme family
ACTI_72060	COG3718	enzyme involved in inositol metabolism
ACTI_72100	COG3384	dioxygenase
ACTI_72110	COG0861	Integral membrane protein TerC family
ACTI_72150	COG0577	efflux transmembrane transporter activity
ACTI_72150	COG1136	(ABC) transporter
ACTI_72160	COG1136	(ABC) transporter
ACTI_72170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACTI_72180	COG2205	protein histidine kinase activity
ACTI_72190	COG0745	RESPONSE REGULATOR receiver
ACTI_72230	COG2197	response regulator
ACTI_72250	COG0406	alpha-ribazole phosphatase activity
ACTI_72280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACTI_72350	COG1309	transcriptional regulator
ACTI_72430	COG0515	serine threonine protein kinase
ACTI_72490	COG1132	(ABC) transporter
ACTI_72500	COG1309	transcriptional regulator
ACTI_72530	COG2382	esterase
ACTI_72570	COG0166	Belongs to the GPI family
ACTI_72620	COG1653	transport
ACTI_72630	COG1175	transmembrane transport
ACTI_72640	COG0395	ABC-type sugar transport system, permease component
ACTI_72680	COG3507	Belongs to the glycosyl hydrolase 43 family
ACTI_72740	COG2197	response regulator
ACTI_72750	COG4585	Histidine kinase
ACTI_72820	COG4214	carbohydrate transport
ACTI_72840	COG4213	ABC transporter substrate-binding protein
ACTI_72880	COG1620	l-lactate permease
ACTI_72890	COG2080	2 iron, 2 sulfur cluster binding
ACTI_72890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACTI_72910	COG1271	oxidase subunit
ACTI_72920	COG1294	oxidase, subunit
ACTI_72930	COG4988	ABC transporter
ACTI_72940	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ACTI_72950	COG5002	protein histidine kinase activity
ACTI_73000	COG3706	GGDEF domain
ACTI_73050	COG2197	response regulator
ACTI_73110	COG2217	Heavy metal translocating P-type atpase
ACTI_73130	COG2909	trisaccharide binding
ACTI_73150	COG0071	Belongs to the small heat shock protein (HSP20) family
ACTI_73260	COG1309	transcriptional regulator
ACTI_73300	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_73310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACTI_73320	COG1309	transcriptional regulator
ACTI_73380	COG1846	Transcriptional regulator
ACTI_73380	COG1940	carbohydrate kinase activity
ACTI_73390	COG3345	alpha-galactosidase
ACTI_73400	COG3458	cephalosporin-C deacetylase activity
ACTI_73470	COG0395	ABC-type sugar transport system, permease component
ACTI_73480	COG4209	transmembrane transport
ACTI_73490	COG1940	carbohydrate kinase activity
ACTI_73490	COG1846	Transcriptional regulator
ACTI_73530	COG3631	Ketosteroid isomerase-related protein
ACTI_73580	COG4948	Mandelate Racemase Muconate Lactonizing
ACTI_73590	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACTI_73630	COG2186	Transcriptional regulator
ACTI_73680	COG0586	Pfam SNARE associated Golgi protein
ACTI_73760	COG5002	protein histidine kinase activity
ACTI_73780	COG1309	transcriptional regulator
ACTI_73830	COG4221	oxidoreductase activity
ACTI_73840	COG1309	transcriptional regulator
ACTI_73850	COG0412	Dienelactone hydrolase
ACTI_73990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACTI_74110	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_74200	COG0789	Transcriptional regulator
ACTI_74210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACTI_74350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACTI_74360	COG3903	Transcriptional regulator
ACTI_74360	COG3629	intracellular signal transduction
ACTI_74370	COG3384	dioxygenase
ACTI_74380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACTI_74390	COG2235	arginine
ACTI_74400	COG0549	Belongs to the carbamate kinase family
ACTI_74430	COG0456	acetyltransferase
ACTI_74500	COG3142	Participates in the control of copper homeostasis
ACTI_74530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_74550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_74570	COG1120	ATPase activity
ACTI_74600	COG2267	carboxylic ester hydrolase activity
ACTI_74660	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_74740	COG0840	transmembrane signaling receptor activity
ACTI_74800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACTI_74920	COG3903	Transcriptional regulator
ACTI_74920	COG3629	intracellular signal transduction
ACTI_74940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACTI_74950	COG3509	depolymerase
ACTI_75030	COG4221	oxidoreductase activity
ACTI_75040	COG0583	DNA-binding transcription factor activity
ACTI_75070	COG0745	RESPONSE REGULATOR receiver
ACTI_75130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACTI_75160	COG0501	Belongs to the peptidase M48B family
ACTI_75180	COG1271	oxidase subunit
ACTI_75190	COG1294	oxidase, subunit
ACTI_75200	COG4988	ABC transporter
ACTI_75310	COG0859	PFAM glycosyl transferase family 9
ACTI_75320	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_75330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACTI_75330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACTI_75340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACTI_75350	COG0297	glycogen (starch) synthase activity
ACTI_75370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACTI_75390	COG2192	nodulation
ACTI_75420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_75480	COG0477	Major facilitator Superfamily
ACTI_75590	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_75620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACTI_75630	COG0326	Molecular chaperone. Has ATPase activity
ACTI_75650	COG2233	PERMEase
ACTI_75720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACTI_75760	COG0297	glycogen (starch) synthase activity
ACTI_75800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACTI_75820	COG0514	ATP-dependent DNA helicase (RecQ)
ACTI_75830	COG2353	YceI-like domain
ACTI_75860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACTI_75860	COG0574	Belongs to the PEP-utilizing enzyme family
ACTI_75920	COG0277	FAD linked oxidase domain protein
ACTI_75930	COG0277	FAD linked oxidase domain protein
ACTI_75940	COG0247	lactate metabolic process
ACTI_75970	COG1414	Transcriptional regulator
ACTI_76030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACTI_76040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_76050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACTI_76060	COG4213	ABC transporter substrate-binding protein
ACTI_76070	COG0395	ABC-type sugar transport system, permease component
ACTI_76080	COG1175	transmembrane transport
ACTI_76110	COG0366	Alpha amylase catalytic
ACTI_76120	COG0494	nUDIX hydrolase
ACTI_76130	COG0009	L-threonylcarbamoyladenylate synthase
ACTI_76160	COG4733	cellulase activity
ACTI_76160	COG5297	Belongs to the glycosyl hydrolase family 6
ACTI_76180	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACTI_76190	COG1653	transport
ACTI_76200	COG1175	transmembrane transport
ACTI_76210	COG0395	ABC-type sugar transport system, permease component
ACTI_76230	COG1136	(ABC) transporter
ACTI_76240	COG1136	(ABC) transporter
ACTI_76240	COG0577	efflux transmembrane transporter activity
ACTI_76310	COG2205	protein histidine kinase activity
ACTI_76320	COG0745	RESPONSE REGULATOR receiver
ACTI_76360	COG0840	transmembrane signaling receptor activity
ACTI_76480	COG1174	glycine betaine transport
ACTI_76490	COG1174	glycine betaine transport
ACTI_76540	COG1609	Transcriptional regulator
ACTI_76550	COG2986	histidine ammonia-lyase
ACTI_76590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACTI_76600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACTI_76630	COG1309	transcriptional regulator
ACTI_76650	COG2205	protein histidine kinase activity
ACTI_76660	COG0745	RESPONSE REGULATOR receiver
ACTI_76730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACTI_76770	COG1716	ATPase activity
ACTI_76840	COG4867	von Willebrand factor, type A
ACTI_76850	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ACTI_76860	COG0384	phenazine biosynthesis protein PhzF
ACTI_76870	COG3467	pyridoxamine 5'-phosphate
ACTI_76880	COG0488	(ABC) transporter
ACTI_76910	COG1649	PFAM Uncharacterised BCR, COG1649
ACTI_76920	COG0297	glycogen (starch) synthase activity
ACTI_76930	COG2199	diguanylate cyclase activity
ACTI_76930	COG2203	Gaf domain
ACTI_76940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACTI_77070	COG2501	S4 domain
ACTI_77100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACTI_77110	COG1366	Belongs to the anti-sigma-factor antagonist family
ACTI_77120	COG1940	carbohydrate kinase activity
ACTI_77150	COG4214	carbohydrate transport
ACTI_77160	COG1129	ABC transporter
ACTI_77180	COG2160	L-arabinose isomerase activity
ACTI_77190	COG1609	Transcriptional regulator
ACTI_77260	COG3300	MHYT domain
ACTI_77260	COG5001	Diguanylate cyclase
ACTI_77280	COG0577	efflux transmembrane transporter activity
ACTI_77280	COG1136	(ABC) transporter
ACTI_77290	COG1136	(ABC) transporter
ACTI_77290	COG0577	efflux transmembrane transporter activity
ACTI_77320	COG2340	Cysteine-rich secretory protein family
ACTI_77350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACTI_77390	COG2201	protein-glutamate methylesterase activity
ACTI_77400	COG3706	GGDEF domain
ACTI_77400	COG0745	RESPONSE REGULATOR receiver
ACTI_77430	COG1136	(ABC) transporter
ACTI_77430	COG0577	efflux transmembrane transporter activity
ACTI_77450	COG2197	response regulator
ACTI_77460	COG3551	Protein conserved in bacteria
ACTI_77480	COG0583	DNA-binding transcription factor activity
ACTI_77550	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACTI_77600	COG0251	oxidation-reduction process
ACTI_77630	COG0840	transmembrane signaling receptor activity
ACTI_77630	COG5278	phosphoserine phosphatase activity
ACTI_77650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACTI_77700	COG1280	lysine exporter protein (LysE YggA)
ACTI_77750	COG3842	ATPase activity
ACTI_77790	COG1120	ATPase activity
ACTI_77800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_77810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_77840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_77850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACTI_77860	COG1120	ATPase activity
ACTI_77900	COG0579	oxidoreductase
ACTI_77910	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_77950	COG2267	carboxylic ester hydrolase activity
ACTI_77960	COG0346	lactoylglutathione lyase activity
ACTI_77970	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACTI_78000	COG0583	DNA-binding transcription factor activity
ACTI_78010	COG4213	ABC transporter substrate-binding protein
ACTI_78020	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACTI_78030	COG1129	ABC transporter
ACTI_78070	COG2205	protein histidine kinase activity
ACTI_78080	COG0745	RESPONSE REGULATOR receiver
ACTI_78100	COG1017	nitric oxide dioxygenase activity
ACTI_78100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACTI_78170	COG3706	GGDEF domain
ACTI_78230	COG1136	(ABC) transporter
ACTI_78230	COG0577	efflux transmembrane transporter activity
ACTI_78240	COG4974	Belongs to the 'phage' integrase family
ACTI_78460	COG4585	Histidine kinase
ACTI_78470	COG2197	response regulator
ACTI_78480	COG5002	protein histidine kinase activity
ACTI_78480	COG5001	Diguanylate cyclase
ACTI_78480	COG3447	MASE1 domain protein
ACTI_78500	COG2200	EAL domain
ACTI_78510	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_78530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACTI_78550	COG0515	serine threonine protein kinase
ACTI_78560	COG0631	protein serine/threonine phosphatase activity
ACTI_78590	COG3903	Transcriptional regulator
ACTI_78590	COG3629	intracellular signal transduction
ACTI_78690	COG0546	phosphoglycolate phosphatase activity
ACTI_78720	COG0805	protein transport
ACTI_78730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACTI_78750	COG2378	regulation of single-species biofilm formation
ACTI_78760	COG2378	regulation of single-species biofilm formation
ACTI_78810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACTI_78820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACTI_78830	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACTI_78860	COG4122	O-methyltransferase activity
ACTI_78880	COG1222	aaa ATPase
ACTI_78920	COG0517	IMP dehydrogenase activity
ACTI_78920	COG1994	Peptidase M50
ACTI_78940	COG2197	response regulator
ACTI_78980	COG1136	(ABC) transporter
ACTI_78980	COG0577	efflux transmembrane transporter activity
ACTI_78990	COG0577	efflux transmembrane transporter activity
ACTI_78990	COG1136	(ABC) transporter
ACTI_79100	COG4585	Histidine kinase
ACTI_79120	COG2197	response regulator
ACTI_79140	COG4585	Histidine kinase
ACTI_79150	COG2197	response regulator
ACTI_79170	COG0215	cysteine-tRNA ligase activity
ACTI_79200	COG0588	phosphoglycerate mutase activity
ACTI_79210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_79220	COG0667	Aldo Keto reductase
ACTI_79250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACTI_79290	COG0542	response to heat
ACTI_79390	COG0745	RESPONSE REGULATOR receiver
ACTI_79410	COG0653	protein targeting
ACTI_79430	COG0673	inositol 2-dehydrogenase activity
ACTI_79440	COG0463	Glycosyl transferase, family 2
ACTI_79490	COG1191	sigma factor activity
ACTI_79570	COG1797	cobyrinic acid a,c-diamide synthase activity
ACTI_79600	COG0577	efflux transmembrane transporter activity
ACTI_79600	COG1136	(ABC) transporter
ACTI_79610	COG1136	(ABC) transporter
ACTI_79610	COG0577	efflux transmembrane transporter activity
ACTI_79670	COG1070	Carbohydrate kinase
ACTI_79720	COG0708	Exodeoxyribonuclease III
ACTI_79780	COG1643	Atp-dependent helicase
ACTI_79790	COG1316	TRANSCRIPTIONal
ACTI_79800	COG0784	Response regulator, receiver
ACTI_79810	COG5002	protein histidine kinase activity
ACTI_79860	COG1940	carbohydrate kinase activity
ACTI_79870	COG3467	pyridoxamine 5'-phosphate
ACTI_79920	COG0366	Alpha amylase catalytic
ACTI_79950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACTI_79960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACTI_79990	COG2197	response regulator
ACTI_80000	COG2183	response to ionizing radiation
ACTI_80100	COG5297	Belongs to the glycosyl hydrolase family 6
ACTI_80110	COG3447	MASE1 domain protein
ACTI_80110	COG5001	Diguanylate cyclase
ACTI_80110	COG5002	protein histidine kinase activity
ACTI_80130	COG1960	acyl-CoA dehydrogenase activity
ACTI_80170	COG0584	glycerophosphoryl diester phosphodiesterase
ACTI_80220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACTI_80230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACTI_80240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACTI_80250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACTI_80270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_80290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACTI_80300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACTI_80360	COG0515	serine threonine protein kinase
ACTI_80420	COG4106	trans-aconitate 2-methyltransferase activity
ACTI_80450	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_80510	COG1802	Transcriptional regulator
ACTI_80530	COG3866	Pectate lyase
ACTI_80560	COG0246	Mannitol dehydrogenase
ACTI_80570	COG1904	glucuronate isomerase
ACTI_80580	COG0673	inositol 2-dehydrogenase activity
ACTI_80590	COG1609	Transcriptional regulator
ACTI_80610	COG1175	transmembrane transport
ACTI_80620	COG0395	ABC-type sugar transport system, permease component
ACTI_80640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACTI_80660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACTI_80700	COG3458	cephalosporin-C deacetylase activity
ACTI_80710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACTI_80770	COG1461	Dihydroxyacetone kinase
ACTI_80780	COG2376	Dihydroxyacetone kinase
ACTI_80790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACTI_80790	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ACTI_80790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACTI_80840	COG0183	Belongs to the thiolase family
ACTI_80850	COG1960	acyl-CoA dehydrogenase activity
ACTI_80860	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_80870	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_80910	COG1476	TRANSCRIPTIONal
ACTI_80920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACTI_80970	COG3940	Belongs to the glycosyl hydrolase 43 family
ACTI_80980	COG2199	diguanylate cyclase activity
ACTI_80980	COG2200	EAL domain
ACTI_80980	COG2202	Pas domain
ACTI_81000	COG2072	flavoprotein involved in K transport
ACTI_81040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACTI_81050	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_81080	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_81100	COG0154	amidase activity
ACTI_81140	COG4608	Belongs to the ABC transporter superfamily
ACTI_81170	COG0601	transmembrane transport
ACTI_81180	COG4166	transmembrane transport
ACTI_81200	COG0477	Major facilitator Superfamily
ACTI_81210	COG1309	transcriptional regulator
ACTI_81230	COG1086	Polysaccharide biosynthesis protein
ACTI_81240	COG0489	protein tyrosine kinase activity
ACTI_81260	COG3959	Transketolase, thiamine diphosphate binding domain
ACTI_81270	COG3958	Transketolase
ACTI_81290	COG1215	transferase activity, transferring glycosyl groups
ACTI_81340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACTI_81490	COG1252	NADH dehydrogenase
ACTI_81500	COG1435	thymidine kinase activity
ACTI_81520	COG1132	(ABC) transporter
ACTI_81530	COG1132	(ABC) transporter
ACTI_81570	COG2301	Belongs to the HpcH HpaI aldolase family
ACTI_81580	COG1960	acyl-CoA dehydrogenase activity
ACTI_81710	COG1960	acyl-CoA dehydrogenase activity
ACTI_81720	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_81750	COG1012	belongs to the aldehyde dehydrogenase family
ACTI_81890	COG0411	ABC transporter
ACTI_81970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACTI_82050	COG1335	isochorismatase
ACTI_82060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACTI_82070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACTI_82080	COG0318	PFAM AMP-dependent synthetase and ligase
ACTI_82180	COG1609	Transcriptional regulator
ACTI_82250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACTI_82260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACTI_82340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACTI_82350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACTI_82350	COG1213	nucleotidyl transferase
ACTI_82410	COG1937	Protein conserved in bacteria
ACTI_82450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACTI_82460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACTI_82510	COG1131	(ABC) transporter
ACTI_82570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACTI_82580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACTI_82600	COG1414	Transcriptional regulator
ACTI_82610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACTI_82670	COG1404	Belongs to the peptidase S8 family
ACTI_82670	COG4412	M6 family metalloprotease domain protein
ACTI_82700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACTI_82820	COG1063	alcohol dehydrogenase
ACTI_82880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACTI_82900	COG1086	Polysaccharide biosynthesis protein
ACTI_82910	COG0438	transferase activity, transferring glycosyl groups
ACTI_82930	COG2197	response regulator
ACTI_82950	COG0702	epimerase
ACTI_82990	COG0515	serine threonine protein kinase
ACTI_83020	COG0477	Major facilitator Superfamily
ACTI_83040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACTI_83090	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_83130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACTI_83140	COG4565	transcriptional regulatory protein
ACTI_83150	COG3290	protein histidine kinase activity
ACTI_83160	COG1301	dicarboxylic acid transport
ACTI_83210	COG4941	Belongs to the sigma-70 factor family
ACTI_83220	COG3795	YCII-related domain
ACTI_83300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACTI_83310	COG0569	domain protein
ACTI_83340	COG2936	dipeptidyl-peptidase activity
ACTI_83370	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACTI_83420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACTI_83430	COG1216	Glycosyl transferase, family 2
ACTI_83440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACTI_83510	COG0667	Aldo Keto reductase
ACTI_83580	COG1882	Formate acetyltransferase
ACTI_83690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ACTI_83740	COG1921	L-seryl-tRNASec selenium transferase activity
ACTI_83750	COG0709	Synthesizes selenophosphate from selenide and ATP
ACTI_83780	COG1522	sequence-specific DNA binding
ACTI_83800	COG2318	DinB family
ACTI_83810	COG1309	transcriptional regulator
ACTI_83820	COG1028	Short-chain dehydrogenase reductase Sdr
ACTI_83850	COG0437	4 iron, 4 sulfur cluster binding
ACTI_83930	COG2226	methyltransferase
ACTI_83960	COG0584	glycerophosphoryl diester phosphodiesterase
ACTI_84010	COG1309	transcriptional regulator
ACTI_84020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACTI_84080	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACTI_84210	COG0515	serine threonine protein kinase
ACTI_84250	COG0477	Major facilitator Superfamily
ACTI_84270	COG4585	Histidine kinase
ACTI_84280	COG2197	response regulator
ACTI_84290	COG2132	Multicopper oxidase
ACTI_84320	COG0477	Major facilitator Superfamily
ACTI_84360	COG2207	Transcriptional regulator
ACTI_84390	COG0840	transmembrane signaling receptor activity
ACTI_84490	COG2226	methyltransferase
ACTI_84510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACTI_84540	COG0024	Methionine aminopeptidase
ACTI_84570	COG3104	oligopeptide transport
ACTI_84580	COG4124	Belongs to the glycosyl hydrolase 26 family
ACTI_84610	COG3833	ABC-type maltose transport systems, permease component
ACTI_84620	COG1175	transmembrane transport
ACTI_84640	COG1609	Transcriptional regulator
ACTI_84650	COG1940	carbohydrate kinase activity
ACTI_84680	COG0384	phenazine biosynthesis protein PhzF
ACTI_84730	COG4948	Mandelate Racemase Muconate Lactonizing
ACTI_84740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACTI_84750	COG0395	ABC-type sugar transport system, permease component
ACTI_84760	COG1175	transmembrane transport
ACTI_84770	COG1653	transport
ACTI_84780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACTI_84800	COG1414	Transcriptional regulator
ACTI_84860	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ACTI_84870	COG1465	3-dehydroquinate synthase
ACTI_84880	COG1830	Aldolase
ACTI_84950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACTI_85030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACTI_85040	COG0659	secondary active sulfate transmembrane transporter activity
ACTI_85060	COG0456	acetyltransferase
ACTI_85080	COG1278	Cold shock
ACTI_85090	COG2208	phosphoserine phosphatase activity
ACTI_85090	COG2770	Histidine kinase
ACTI_85200	COG0745	RESPONSE REGULATOR receiver
ACTI_85260	COG0515	serine threonine protein kinase
ACTI_85270	COG0210	DNA helicase
ACTI_85300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair