locus-tag class description ACWT_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ACWT_0003 ENOG4108J5G 6-phosphogluconate dehydrogenase ACWT_0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ACWT_0005 ENOG4105K7N UPF0232 protein ACWT_0008 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACWT_0009 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACWT_0014 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_0015 ENOG4105BZU Histidine kinase ACWT_0018 ENOG4105E09 nadh pyrophosphatase ACWT_0021 ENOG4107ZXU DSBA oxidoreductase ACWT_0026 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ACWT_0029 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ACWT_0030 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase ACWT_0033 ENOG4107QX3 carboxylase ACWT_0034 ENOG4105C1G acyl-Coa dehydrogenase ACWT_0036 ENOG41090MY MarR family Transcriptional regulator ACWT_0044 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family ACWT_0045 ENOG4105TV9 FHA Domain-Containing protein ACWT_0045 ENOG4105TV9 FHA Domain-Containing protein ACWT_0046 ENOG4105HZM Fha domain containing protein ACWT_0049 ENOG4105CJN penicillin-binding protein ACWT_0050 ENOG4107TPY serine threonine protein kinase ACWT_0051 ENOG4105D9P serine threonine protein kinase ACWT_0056 ENOG4105ZJT Cell division protein CrgA ACWT_0057 ENOG4105DF6 Fe-S oxidoreductase ACWT_0062 ENOG4105DHP deoxycytidine triphosphate deaminase ACWT_0065 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) ACWT_0068 ENOG4105CSU acyl-Coa dehydrogenase ACWT_0078 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 ACWT_0079 ENOG4105CPP Dehydrogenase, E1 component ACWT_0085 ENOG4105CFG Acts as a chaperone (By similarity) ACWT_0086 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ACWT_0087 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ACWT_0088 ENOG4105KNI merR family transcriptional Regulator ACWT_0090 ENOG4107W2M Sodium hydrogen exchanger ACWT_0092 ENOG4105S8Q sugar efflux transporter ACWT_0093 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACWT_0097 ENOG4107YCR Transcriptional regulator, ARSR family ACWT_0099 ENOG4105DQR SNARE associated Golgi ACWT_0100 ENOG4107S1Q Phosphatase ACWT_0111 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ACWT_0112 ENOG4105C12 Phosphoribosylglycinamide synthetase ACWT_0116 ENOG410839H phosphoribosylformylglycinamidine synthase ACWT_0117 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I ACWT_0118 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii ACWT_0122 ENOG4105CXB phosphoribosylaminoimidazole synthetase ACWT_0130 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) ACWT_0134 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) ACWT_0138 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) ACWT_0142 ENOG4105CVP deoxyribo-dipyrimidine photolyase ACWT_0143 ENOG4107QN2 dihydrolipoyl dehydrogenase ACWT_0146 ENOG4107TPY serine threonine protein kinase ACWT_0147 ENOG4105DU6 RNA polymerase ACWT_0149 ENOG4105DSE periplasmic solute binding protein ACWT_0150 ENOG4105DIK (ABC) transporter ACWT_0151 ENOG4105CC5 ABC transporter ACWT_0154 ENOG4108PJD permease ACWT_0164 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ACWT_0168 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACWT_0185 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) ACWT_0190 ENOG4105BZU Histidine kinase ACWT_0196 ENOG41062JF Transcriptional regulator ACWT_0197 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACWT_0200 ENOG4105BZU Histidine kinase ACWT_0209 ENOG4105CJ1 ABC, transporter ACWT_0211 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ACWT_0212 ENOG4105ETX regulatoR ACWT_0213 ENOG4105BZU Histidine kinase ACWT_0218 ENOG4105E4C Lytic transglycosylase catalytic ACWT_0219 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 ACWT_0221 ENOG410880H cysteine synthase ACWT_0225 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACWT_0236 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_0238 ENOG4105C1B dTDP-glucose 4-6-dehydratase ACWT_0244 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) ACWT_0245 ENOG4108Q50 Histidine kinase ACWT_0247 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) ACWT_0248 ENOG4105CPF Cell wall formation (By similarity) ACWT_0249 ENOG4105C87 Aminotransferase class I and II ACWT_0257 ENOG4105C22 threonyL-tRNA synthetase ACWT_0260 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ACWT_0264 ENOG4108KXV response regulator ACWT_0265 ENOG4105BZU Histidine kinase ACWT_0267 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase ACWT_0268 ENOG4105FUA antagonist ACWT_0269 ENOG4107MMM Anti-sigma-factor antagonist ACWT_0271 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ACWT_0280 ENOG4105NAE bifunctional deaminase-reductase domain protein ACWT_0281 ENOG4105NAE bifunctional deaminase-reductase domain protein ACWT_0283 ENOG4105BZU Histidine kinase ACWT_0284 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ACWT_0288 ENOG41084GC stage II sporulation protein ACWT_0289 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ACWT_0290 ENOG4108RH7 phosphoglycerate mutase ACWT_0291 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ACWT_0292 ENOG4107QIV Cytochrome c biogenesis protein ACWT_0294 ENOG4105CRE cytochrome C ACWT_0296 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ACWT_0298 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ACWT_0303 ENOG4105C1J atp-dependent rna helicase ACWT_0305 ENOG4105ZXU NLP P60 protein ACWT_0306 ENOG4105DVY radical SAM domain protein ACWT_0310 ENOG4105EHG Permease protein ACWT_0311 ENOG4105E0A ABC, transporter ACWT_0317 ENOG4105EEM helicase ACWT_0320 ENOG4105EV6 Pfam:DUF178 ACWT_0321 ENOG4105CPC Aldo Keto reductase ACWT_0322 ENOG4107XWB Zinc finger, swim domain protein ACWT_0323 ENOG4105C0D helicase ACWT_0326 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) ACWT_0327 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_0331 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0332 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ACWT_0333 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0336 ENOG4108IEH NADH dehydrogenase subunit g ACWT_0337 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) ACWT_0338 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0339 ENOG41087XN oxidoreductase ACWT_0340 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0343 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0348 ENOG41082T9 Membrane ACWT_0355 ENOG4105D74 hydrolase ACWT_0357 ENOG4107G87 m6 family metalloprotease domain protein ACWT_0358 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ACWT_0369 ENOG4108I5C dEAD DEAH box helicase ACWT_0370 ENOG4105WN5 stage II sporulation protein ACWT_0372 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for ACWT_0375 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ACWT_0377 ENOG4108SGK Tetr family transcriptional regulator ACWT_0379 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ACWT_0381 ENOG4105C6E dna polymerase iii ACWT_0387 ENOG4105MA4 psp1 domain protein ACWT_0392 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACWT_0395 ENOG4106UW1 Major Facilitator superfamily ACWT_0404 ENOG4105DQE DNA ligase ACWT_0406 ENOG4105FDF Could be involved in DNA repair (By similarity) ACWT_0407 ENOG41062IR nudix hydrolase ACWT_0411 ENOG4105CFI type iii restriction protein res subunit ACWT_0414 ENOG4105VEQ Cold shock protein ACWT_0415 ENOG4105E63 Pfam:DUF178 ACWT_0421 ENOG4108UIH futalosine nucleosidase ACWT_0422 ENOG4108N0W Major Facilitator superfamily ACWT_0427 ENOG4105C7N Xanthine uracil vitamin C permease ACWT_0428 ENOG4105K56 Transcriptional regulator ACWT_0429 ENOG4107SFI Major Facilitator superfamily ACWT_0431 ENOG41081HM 2'-5' rna ligase ACWT_0433 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ACWT_0435 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) ACWT_0437 ENOG4107WI4 Aldose-1-epimerase ACWT_0443 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACWT_0449 ENOG4105EY8 ABC transporter ACWT_0451 ENOG4108JGH Tetr family transcriptional regulator ACWT_0465 ENOG4105ETX regulatoR ACWT_0466 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ACWT_0467 ENOG4105BZU Histidine kinase ACWT_0468 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_0471 ENOG41083YR Protein CrcB homolog ACWT_0472 ENOG4105BZU Histidine kinase ACWT_0474 ENOG4107QN2 dihydrolipoyl dehydrogenase ACWT_0479 ENOG4106JDR secreted ACWT_0494 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ACWT_0495 ENOG4105EGE secreted protein ACWT_0496 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator ACWT_0497 ENOG4105CNN ABC, transporter ACWT_0498 ENOG4105C2J ABC transporter ACWT_0500 ENOG4105BZU Histidine kinase ACWT_0502 ENOG4108X07 Tetr family transcriptional regulator ACWT_0503 ENOG4105CIG ABC transporter ACWT_0504 ENOG4105DIM ABC transporter ACWT_0507 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) ACWT_0510 ENOG4105GRZ Ycii-related protein ACWT_0511 ENOG4105CHP RNA polymerase ACWT_0512 ENOG4106YBV Methyl-accepting chemotaxis ACWT_0515 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ACWT_0516 ENOG4105C54 Major Facilitator superfamily ACWT_0518 ENOG4105F4R Transcriptional regulator mode ACWT_0524 ENOG4105RD7 BadF BadG BcrA BcrD ACWT_0525 ENOG4106KNT transcriptional regulator ACWT_0526 ENOG4108SU4 UPF0309 protein ACWT_0533 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACWT_0534 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACWT_0537 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ACWT_0538 ENOG4105FDP GntR family transcriptional regulator ACWT_0540 ENOG4105JVQ RNA Polymerase ACWT_0544 ENOG4105BZU Histidine kinase ACWT_0546 ENOG4105BZU Histidine kinase ACWT_0554 ENOG4105EYF MMPL domain protein ACWT_0559 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ACWT_0560 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ACWT_0561 ENOG4108NJZ Sensory box GGDEF EAL domain protein ACWT_0562 ENOG4106UDK Cellulose-binding, family II ACWT_0563 ENOG4105CGH 5'-nucleotidase ACWT_0564 ENOG4105DND Transcriptional regulator ACWT_0567 ENOG4105EG6 Saccharopine dehydrogenase ACWT_0568 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ACWT_0574 ENOG4105EDW glycosyl transferase, family 39 ACWT_0575 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ACWT_0576 ENOG4105BZU Histidine kinase ACWT_0577 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_0582 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_0583 ENOG4105BZU Histidine kinase ACWT_0585 ENOG4108MWI inositol mono-phosphatase ACWT_0586 ENOG4105CHR reductase ACWT_0588 ENOG4105D9P serine threonine protein kinase ACWT_0591 ENOG4105C9U ATP-dependent DNA helicase RecQ ACWT_0594 ENOG4105VPX protein, conserved in bacteria ACWT_0600 ENOG4105C1J atp-dependent rna helicase ACWT_0610 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ACWT_0611 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ACWT_0613 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) ACWT_0616 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ACWT_0619 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0622 ENOG4105EMN RNA polymerase sigma factor ACWT_0623 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ACWT_0624 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) ACWT_0625 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0626 ENOG4107YX3 NADH dehydrogenase subunit j ACWT_0627 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_0629 ENOG4105C8S subunit m ACWT_0631 ENOG4105D0M Protease HtpX homolog ACWT_0633 ENOG4105DEN Luciferase family ACWT_0639 ENOG4108VPT UPF0234 protein ACWT_0641 ENOG4105N14 lysine exporter protein LysE YggA ACWT_0642 ENOG4105KHC sulfurtransferase ACWT_0645 ENOG4105BZU Histidine kinase ACWT_0646 ENOG4105WDJ 50S ribosomal protein L33 ACWT_0647 ENOG410900P UPF0336 protein ACWT_0651 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ACWT_0652 ENOG4105FDK ABC transporter ACWT_0654 ENOG4108VZM 50s ribosomal protein L10 ACWT_0655 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ACWT_0656 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ACWT_0657 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ACWT_0660 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ACWT_0661 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ACWT_0662 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ACWT_0663 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ACWT_0664 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ACWT_0665 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ACWT_0666 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ACWT_0667 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ACWT_0668 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ACWT_0669 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ACWT_0670 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ACWT_0671 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ACWT_0672 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ACWT_0673 ENOG41082SA 50s ribosomal protein l29 ACWT_0674 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ACWT_0675 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ACWT_0676 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ACWT_0677 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ACWT_0678 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ACWT_0679 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ACWT_0680 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ACWT_0681 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ACWT_0682 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ACWT_0683 ENOG410849U 50S ribosomal protein L30 ACWT_0684 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ACWT_0685 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ACWT_0686 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ACWT_0689 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ACWT_0690 ENOG41067V7 50S ribosomal protein L36 ACWT_0691 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ACWT_0692 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ACWT_0693 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ACWT_0695 ENOG4108ZT0 50S ribosomal protein l17 ACWT_0696 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ACWT_0698 ENOG4107Y49 methyltransferase ACWT_0703 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ACWT_0704 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ACWT_0706 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ACWT_0712 ENOG4105GWZ Roadblock lc7 family protein ACWT_0716 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ACWT_0717 ENOG4108UJD 30S ribosomal protein S9 ACWT_0718 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ACWT_0721 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ACWT_0725 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ACWT_0727 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ACWT_0729 ENOG4108097 ATP-binding protein ACWT_0730 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ACWT_0733 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ACWT_0735 ENOG4105BZ1 (ABC) transporter ACWT_0737 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ACWT_0738 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ACWT_0740 ENOG4108Z66 YbaK ebsC protein ACWT_0741 ENOG4105DFW ABC transporter ACWT_0742 ENOG4105C2J ABC transporter ACWT_0743 ENOG4107RNG ABC transporter ACWT_0749 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ACWT_0750 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_0751 ENOG4108VT4 ACWT_0753 ENOG4107QVP Dehydrogenase ACWT_0755 ENOG4108KGH TRANSCRIPTIONal ACWT_0756 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ACWT_0757 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ACWT_0758 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ACWT_0759 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase ACWT_0760 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme ACWT_0763 ENOG4108XG2 Histidine kinase ACWT_0764 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_0765 ENOG4108J59 Extracellular solute-binding protein, family 5 ACWT_0766 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACWT_0767 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACWT_0768 ENOG4105C3U ABC transporter ACWT_0769 ENOG4108JQ7 (ABC) transporter ACWT_0770 ENOG4106D2I Chorismate mutase ACWT_0773 ENOG4105DR5 peptidase ACWT_0776 ENOG4105CMV Succinyl-CoA synthetase subunit beta ACWT_0780 ENOG4105DC1 bifunctional purine biosynthesis protein purh ACWT_0785 ENOG4105MVE transcriptional regulator ACWT_0798 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) ACWT_0800 ENOG4105CIG ABC transporter ACWT_0802 ENOG4105CJ1 ABC, transporter ACWT_0804 ENOG4105YVS arsR family transcriptional regulator ACWT_0805 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ACWT_0808 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ACWT_0809 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ACWT_0816 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ACWT_0825 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_0831 ENOG4105CHU acetyl-coa acetyltransferase ACWT_0838 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ACWT_0839 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) ACWT_0840 ENOG4105CSR polyphosphate kinase 2 ACWT_0845 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ACWT_0849 ENOG4105C7B Threonine dehydratase ACWT_0850 ENOG4105D0M Protease HtpX homolog ACWT_0851 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ACWT_0853 ENOG4105T1M mycothiol conjugate amidase mca ACWT_0855 ENOG4105BZU Histidine kinase ACWT_0857 ENOG4105C7Z Conserved Protein ACWT_0859 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ACWT_0872 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_0877 ENOG41088F7 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ACWT_0882 ENOG4105DBV ornithine carbamoyltransferase ACWT_0911 ENOG4107SNV Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ACWT_0916 ENOG4105ETE Transcriptional regulator (LacI family ACWT_0919 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACWT_0920 ENOG4105C28 cystathionine ACWT_0923 ENOG4108S4H thioesterase Superfamily protein ACWT_0925 ENOG4105E2K Glycosyl transferase (Group 1 ACWT_0926 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ACWT_0929 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) ACWT_0930 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase ACWT_0932 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) ACWT_0933 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ACWT_0938 ENOG4105C26 Dehydrogenase ACWT_0939 ENOG4107RR1 TRANSCRIPTIONal ACWT_0940 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) ACWT_0941 ENOG4107QKV phosphomannomutase ACWT_0942 ENOG4105W49 UPF0434 protein ACWT_0945 ENOG4105EIP mannose-6-phosphate isomerase ACWT_0948 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_0949 ENOG4105BZU Histidine kinase ACWT_0952 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea ACWT_0954 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ACWT_0960 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ACWT_0961 ENOG4105CAK Cell division ATP-binding protein ftsE ACWT_0962 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) ACWT_0963 ENOG4105E4C Lytic transglycosylase catalytic ACWT_0964 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ACWT_0993 ENOG4105EMN RNA polymerase sigma factor ACWT_0995 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ACWT_0996 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ACWT_0999 ENOG4108UJU UPF0301 protein ACWT_1000 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) ACWT_1001 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_1002 ENOG4105DYW oxidoreductase ACWT_1009 ENOG4105CZX twitching motility protein ACWT_1010 ENOG4107QHF type ii secretion system protein e ACWT_1013 ENOG41082AN stage II sporulation protein ACWT_1015 ENOG4105BZU Histidine kinase ACWT_1031 ENOG4105BZU Histidine kinase ACWT_1035 ENOG4105DQE DNA ligase ACWT_1036 ENOG41061H0 Monooxygenase ACWT_1037 ENOG4105BZ9 Cytochrome C oxidase, subunit I ACWT_1038 ENOG4105DDI hemolysin-type calcium-binding region ACWT_1040 ENOG4105DYW oxidoreductase ACWT_1042 ENOG4108RWI nicotinamidase ACWT_1043 ENOG4107RKP Nicotinate phosphoribosyltransferase ACWT_1044 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ACWT_1050 ENOG4108RQ5 Beta-lactamase domain-containing protein ACWT_1051 ENOG4108MJN Glycosyl Transferase ACWT_1052 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ACWT_1053 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ACWT_1054 ENOG4105C84 Histidine ammonia-lyase ACWT_1055 ENOG4105CI2 imidazolone-5-propionate hydrolase ACWT_1056 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) ACWT_1057 ENOG4105CE7 Amidase, hydantoinase carbamoylase family ACWT_1058 ENOG4105CGP Urocanate hydratase ACWT_1063 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) ACWT_1071 ENOG4108T5E Copper resistance protein ACWT_1073 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ACWT_1077 ENOG4106R7G Glycoside hydrolase family 5 ACWT_1081 ENOG4105W1N transcriptional regulator ACWT_1082 ENOG4105IIP Membrane ACWT_1087 ENOG4105CYP glycoside hydrolase, family ACWT_1089 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_1092 ENOG4106A3M Cytochrome p-450 ACWT_1094 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ACWT_1097 ENOG4105BZU Histidine kinase ACWT_1108 ENOG410829K Lysine exporter protein (Lyse ygga) ACWT_1115 ENOG4105QE3 oxidoreductase ACWT_1117 ENOG4105F44 Two component transcriptional regulator, winged helix family ACWT_1118 ENOG4105BZU Histidine kinase ACWT_1121 ENOG4105D7N magnesium and cobalt transport protein CorA ACWT_1124 ENOG4105E2D ec 3.2.1.52 ACWT_1134 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) ACWT_1139 ENOG4105CNH Multidrug resistance protein MdtL ACWT_1140 ENOG4105CG3 alpha amylase, catalytic region ACWT_1141 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACWT_1147 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ACWT_1151 ENOG4105WX6 Membrane ACWT_1162 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_1165 ENOG4108JQ1 Dehydrogenase ACWT_1173 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) ACWT_1174 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ACWT_1175 ENOG4105D0M Protease HtpX homolog ACWT_1176 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ACWT_1179 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) ACWT_1182 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ACWT_1184 ENOG4108JQC penicillin-binding protein 1A ACWT_1186 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ACWT_1187 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ACWT_1188 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase ACWT_1197 ENOG4105D8X mechanosensitive ion channel ACWT_1202 ENOG4109057 ACWT_1205 ENOG4105MC2 DSBA oxidoreductase ACWT_1208 ENOG4105E66 phosphoriboisomerase A ACWT_1214 ENOG4105NPE arsR family transcriptional regulator ACWT_1219 ENOG4105K6V RNA polymerase ACWT_1220 ENOG4105YVS arsR family transcriptional regulator ACWT_1221 ENOG4107XZQ multidrug resistance protein ACWT_1226 ENOG4105E2A Dehydrogenase ACWT_1228 ENOG4108Z0Z intracellular protease Pfpi family ACWT_1231 ENOG4105M6F mutator MutT protein ACWT_1232 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ACWT_1233 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ACWT_1234 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ACWT_1235 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ACWT_1240 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ACWT_1241 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ACWT_1244 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ACWT_1245 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ACWT_1248 ENOG4107R6F Alpha Beta Hydrolase Fold protein ACWT_1249 ENOG4108Q50 Histidine kinase ACWT_1253 ENOG4105C03 ribonuclease ACWT_1255 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ACWT_1256 ENOG4105K46 50S ribosomal protein l27 ACWT_1257 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ACWT_1258 ENOG41082BV acetyltransferase ACWT_1259 ENOG4105C31 Tryptophanyl-tRNA synthetase ACWT_1262 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ACWT_1264 ENOG4105CVJ phosphoglycerate mutase ACWT_1266 ENOG4105EPR degv family ACWT_1268 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ACWT_1269 ENOG4105KQC Competence protein ACWT_1270 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ACWT_1273 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) ACWT_1277 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ACWT_1278 ENOG4105Y3U Transglycosylase-associated protein ACWT_1281 ENOG4105E39 Enoyl-CoA hydratase ACWT_1284 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) ACWT_1285 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ACWT_1287 ENOG4105K7K Transcriptional regulator ACWT_1289 ENOG4107QK4 glycoside hydrolase, family 3 domain protein ACWT_1290 ENOG4105K59 histidine triad (HIT) protein ACWT_1293 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ACWT_1296 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ACWT_1299 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) ACWT_1300 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ACWT_1307 ENOG4108JJB ABC transporter ACWT_1309 ENOG4108JNI Alpha beta hydrolase ACWT_1315 ENOG4105FDK ABC transporter ACWT_1316 ENOG4105DSE periplasmic solute binding protein ACWT_1320 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) ACWT_1322 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family ACWT_1326 ENOG4105GWZ Roadblock lc7 family protein ACWT_1331 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ACWT_1334 ENOG4105CJ1 ABC, transporter ACWT_1337 ENOG4107S2Z UPF0761 membrane protein ACWT_1345 ENOG4105KRQ Addiction module toxin, Txe YoeB family ACWT_1346 ENOG41084HI prevent-host-death family ACWT_1351 ENOG4105CHR reductase ACWT_1352 ENOG4108Z6Z Transcriptional regulator ACWT_1356 ENOG4106UDK Cellulose-binding, family II ACWT_1358 ENOG4105CNT hydrolase family 2 ACWT_1364 ENOG4108V3W Chemotaxis protein, CheW ACWT_1365 ENOG4107SDU Methyl-accepting chemotaxis ACWT_1371 ENOG4108AQF aminoglycoside N(3)-acetyltransferase ACWT_1383 ENOG4105C75 arginyL-tRNA synthetase ACWT_1384 ENOG4105CGH 5'-nucleotidase ACWT_1387 ENOG4107TPY serine threonine protein kinase ACWT_1391 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ACWT_1394 ENOG4105EEM helicase ACWT_1399 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ACWT_1402 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ACWT_1403 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ACWT_1409 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ACWT_1410 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ACWT_1411 ENOG4107ZED Uncharacterised protein family UPF0047 ACWT_1417 ENOG4105EVI UPF0374 protein ACWT_1422 ENOG4105EGD dinuclear metal center protein, YbgI family ACWT_1424 ENOG4105CVJ phosphoglycerate mutase ACWT_1430 ENOG4105EJ9 Membrane ACWT_1432 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ACWT_1433 ENOG4105C7B Threonine dehydratase ACWT_1436 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_1440 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) ACWT_1441 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ACWT_1442 ENOG4105C4K Nad synthetase ACWT_1443 ENOG4105C5F glutamine synthetase ACWT_1444 ENOG4105P3N Membrane ACWT_1446 ENOG4105D29 Helix-turn-helix type 11 domain protein ACWT_1449 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ACWT_1450 ENOG4105K56 Transcriptional regulator ACWT_1452 ENOG41090CE integral membrane protein ACWT_1453 ENOG4108U8T Mannosyltransferase ACWT_1465 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_1479 ENOG4105EC2 ftsk spoIIIe ACWT_1487 ENOG4107SM8 Adenylate Guanylate cyclase ACWT_1489 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ACWT_1490 ENOG4105C5S asparaginyl-tRNA synthetase ACWT_1492 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ACWT_1498 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ACWT_1499 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ACWT_1500 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) ACWT_1501 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ACWT_1503 ENOG4107XZ0 Peptidase M50 ACWT_1504 ENOG4105CPC Aldo Keto reductase ACWT_1509 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ACWT_1512 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ACWT_1513 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ACWT_1514 ENOG4105BZW Glycerate kinase ACWT_1518 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ACWT_1519 ENOG4105C3J Cysteine desulfurase ACWT_1520 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) ACWT_1521 ENOG4108ZRS Part of cytochrome c oxidase, its function is ACWT_1523 ENOG4108I0Q anthranilate phosphoribosyltransferase ACWT_1534 ENOG4108S0S Nucleotidyl transferase ACWT_1536 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACWT_1540 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 ACWT_1541 ENOG4105JNK Glycosyl transferase (Group 1 ACWT_1543 ENOG4105BZ1 (ABC) transporter ACWT_1548 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_1552 ENOG4105DKQ ROK family ACWT_1554 ENOG4105F95 Monooxygenase ACWT_1558 ENOG4105F6E Acyl-transferase ACWT_1564 ENOG4105CTQ phosphohexokinase ACWT_1574 ENOG4108V06 Glutathione peroxidase ACWT_1576 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase ACWT_1580 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ACWT_1597 ENOG4108SGK Tetr family transcriptional regulator ACWT_1599 ENOG4105E33 succinate dehydrogenase ACWT_1602 ENOG4105F04 LysR family Transcriptional regulator ACWT_1609 ENOG4108ZIP spheroidene monooxygenase ACWT_1625 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_1626 ENOG4105C8T Leucyl-tRNA synthetase ACWT_1628 ENOG4105F1K Glutamine amidotransferase ACWT_1629 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ACWT_1631 ENOG4108V6E Cell division protein mraZ ACWT_1632 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ACWT_1634 ENOG4105CJN penicillin-binding protein ACWT_1635 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ACWT_1637 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ACWT_1639 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ACWT_1640 ENOG4105DFU Cell wall formation (By similarity) ACWT_1642 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ACWT_1644 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) ACWT_1646 ENOG4107VQS DivIVA family ACWT_1650 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ACWT_1654 ENOG4105C0B DNA polymerase III (alpha subunit) ACWT_1656 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ACWT_1657 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ACWT_1658 ENOG4105CIH Imidazole acetol-phosphate transaminase ACWT_1659 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ACWT_1662 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ACWT_1663 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ACWT_1667 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACWT_1669 ENOG4108IQE Amp-dependent synthetase and ligase ACWT_1670 ENOG4108U3T pfkb domain protein ACWT_1673 ENOG4105DVH amino acid ACWT_1675 ENOG4105BZ1 (ABC) transporter ACWT_1676 ENOG4105BZ1 (ABC) transporter ACWT_1677 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ACWT_1680 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ACWT_1684 ENOG4105DK0 Indole-3-glycerol phosphate synthase ACWT_1686 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ACWT_1688 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ACWT_1691 ENOG4105CBC glutamate synthase ACWT_1698 ENOG4105C32 Amino acid ABC transporter (Permease) ACWT_1699 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ACWT_1700 ENOG4105C0Z ABC transporter ACWT_1701 ENOG4108IV0 ABC, transporter ACWT_1703 ENOG4105EAD ABC transporter ACWT_1709 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_1710 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ACWT_1711 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ACWT_1714 ENOG41061CK Antibiotic biosynthesis monooxygenase ACWT_1716 ENOG4105CI3 gtp-binding protein typa ACWT_1718 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ACWT_1719 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ACWT_1722 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ACWT_1724 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ACWT_1726 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ACWT_1728 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ACWT_1729 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ACWT_1731 ENOG4105CIE May be required for sporulation (By similarity) ACWT_1732 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ACWT_1733 ENOG4105BZA Phosphoglycerate kinase ACWT_1734 ENOG4105CP7 Triose-phosphate isomerase ACWT_1739 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) ACWT_1742 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ACWT_1743 ENOG4105CV1 Transketolase (EC 2.2.1.1) ACWT_1744 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ACWT_1752 ENOG4105C3K feS assembly ATPase SufC ACWT_1753 ENOG4105C9B Cysteine desulfurase ACWT_1754 ENOG4108UNV SUF system FeS assembly protein, NifU family ACWT_1761 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ACWT_1765 ENOG4105CGZ zinc metallopeptidase ACWT_1766 ENOG4105C5H ABC transporter ACWT_1768 ENOG4105E39 Enoyl-CoA hydratase ACWT_1769 ENOG4105BZ1 (ABC) transporter ACWT_1770 ENOG4108VCA G U mismatch-specific DNA glycosylase ACWT_1771 ENOG4105CHR reductase ACWT_1774 ENOG4108Q5F Tetr family transcriptional regulator ACWT_1776 ENOG4105CHR reductase ACWT_1780 ENOG4107QM5 aconitate hydratase ACWT_1783 ENOG4107T6F Xaa-Pro aminopeptidase ACWT_1785 ENOG4105D7K pfkb domain protein ACWT_1790 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_1793 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_1794 ENOG4108ZGX Histidine kinase ACWT_1796 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ACWT_1797 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ACWT_1812 ENOG4108428 Inherit from COG: -acetyltransferase ACWT_1815 ENOG410783G ACWT_1816 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ACWT_1819 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component ACWT_1820 ENOG4105DRS transport system, permease ACWT_1822 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ACWT_1823 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component ACWT_1824 ENOG4105C2M dna polymerase I ACWT_1825 ENOG4105C3R Methionine synthase ACWT_1826 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ACWT_1831 ENOG4105BZU Histidine kinase ACWT_1832 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_1834 ENOG4105BZU Histidine kinase ACWT_1847 ENOG410901E Membrane ACWT_1852 ENOG4105DMF Dehydrogenase ACWT_1853 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ACWT_1854 ENOG4105BZ9 Cytochrome C oxidase, subunit I ACWT_1856 ENOG4108X07 Tetr family transcriptional regulator ACWT_1859 ENOG4108JGH Tetr family transcriptional regulator ACWT_1860 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase ACWT_1863 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_1865 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ACWT_1866 ENOG4105D9P serine threonine protein kinase ACWT_1874 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_1879 ENOG4105BZU Histidine kinase ACWT_1887 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ACWT_1889 ENOG4105BZU Histidine kinase ACWT_1890 ENOG4105C08 Histidine kinase ACWT_1891 ENOG4105BZU Histidine kinase ACWT_1894 ENOG4105BZU Histidine kinase ACWT_1895 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) ACWT_1898 ENOG41062D9 Histidine kinase ACWT_1900 ENOG4105ESN nucleotide-binding protein ACWT_1902 ENOG4108PA7 Methyltransferase ACWT_1903 ENOG4105BZP glycoside hydrolase 15-related ACWT_1904 ENOG4107Y9E nuclease ACWT_1905 ENOG4107S5I aldo keto reductase ACWT_1916 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACWT_1919 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ACWT_1920 ENOG4105C2J ABC transporter ACWT_1922 ENOG4105CNN ABC, transporter ACWT_1927 ENOG4108KGH TRANSCRIPTIONal ACWT_1928 ENOG4105K64 Glycosyl transferase, family 2 ACWT_1929 ENOG4107T8Q Glycosyl transferase (Group 1 ACWT_1936 ENOG4105PGM cation diffusion facilitator family transporter ACWT_1940 ENOG4108NGU Transcriptional regulator ACWT_1945 ENOG4105BZU Histidine kinase ACWT_1948 ENOG4105EA8 2-Nitropropane dioxygenase ACWT_1954 ENOG4105CHM Aminotransferase ACWT_1960 ENOG4108FN7 Aldo keto reductase ACWT_1987 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACWT_1990 ENOG410620I Diguanylate cyclase ACWT_1993 ENOG4105E4C Lytic transglycosylase catalytic ACWT_1998 ENOG4105D9U N-acetyltransferase ACWT_2001 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACWT_2002 ENOG4105D78 K07001 NTE family protein ACWT_2007 ENOG4105BZF Glycosyl transferase (Group 1 ACWT_2011 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ACWT_2018 ENOG4105CMG Carbohydrate kinase ACWT_2019 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ACWT_2023 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) ACWT_2025 ENOG4108UQY Iron-storage protein ACWT_2027 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACWT_2032 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component ACWT_2033 ENOG4105F8D glycoside hydrolase family 4 ACWT_2038 ENOG4108NVR Methyl-accepting chemotaxis ACWT_2039 ENOG4105CWX Alpha-1,2-mannosidase ACWT_2040 ENOG4105ETE Transcriptional regulator (LacI family ACWT_2053 ENOG4105C1G acyl-Coa dehydrogenase ACWT_2054 ENOG4105CPQ Dehydrogenase ACWT_2055 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase ACWT_2056 ENOG4105MXW flavin reductase domain protein, FMN-binding ACWT_2058 ENOG4105EQ0 Major Facilitator superfamily ACWT_2060 ENOG4105E8G Major facilitator Superfamily ACWT_2072 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_2073 ENOG4105C2C drug resistance transporter, Bcr CflA ACWT_2076 ENOG41068CG regulatoR ACWT_2077 ENOG4105BZU Histidine kinase ACWT_2083 ENOG4105ETX regulatoR ACWT_2105 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_2120 ENOG4105DHQ Histidine kinase ACWT_2123 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) ACWT_2128 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_2131 ENOG4108Q50 Histidine kinase ACWT_2133 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ACWT_2140 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_2148 ENOG4105BZU Histidine kinase ACWT_2149 ENOG4105BZU Histidine kinase ACWT_2151 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_2152 ENOG4105F27 Major Facilitator ACWT_2157 ENOG4105CWX Alpha-1,2-mannosidase ACWT_2162 ENOG4108Z4X TRANSCRIPTIONal ACWT_2163 ENOG4105CHR reductase ACWT_2168 ENOG4105G7B Protein of unknown function (DUF2992) ACWT_2182 ENOG4105ETE Transcriptional regulator (LacI family ACWT_2189 ENOG4105DET Rhamnulokinase ACWT_2190 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ACWT_2191 ENOG4107QR9 Iron-sulfur cluster binding protein ACWT_2192 ENOG41080R8 Conserved Protein ACWT_2193 ENOG4105BZU Histidine kinase ACWT_2194 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_2195 ENOG4105BZU Histidine kinase ACWT_2198 ENOG4105C1P efflux transporter, rnd family, mfp subunit ACWT_2199 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_2200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_2204 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ACWT_2207 ENOG4105DTQ mandelate racemase muconate lactonizing ACWT_2210 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ACWT_2214 ENOG4105EGE secreted protein ACWT_2222 ENOG4106JDR secreted ACWT_2224 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ACWT_2225 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ACWT_2227 ENOG4107HP6 Transcriptional regulator ACWT_2231 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ACWT_2232 ENOG4105BZU Histidine kinase ACWT_2238 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase ACWT_2239 ENOG4107HP6 Transcriptional regulator ACWT_2241 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta ACWT_2242 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase ACWT_2243 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase ACWT_2244 ENOG4105HSS phospholipase C ACWT_2249 ENOG4108VB1 regulatoR ACWT_2255 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ACWT_2260 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ACWT_2277 ENOG4107R5B glutamine synthetase ACWT_2281 ENOG4105WBV Transcriptional regulator ACWT_2284 ENOG4105CS9 pantothenic acid kinase ACWT_2291 ENOG4105C1G acyl-Coa dehydrogenase ACWT_2293 ENOG4105C1G acyl-Coa dehydrogenase ACWT_2294 ENOG4108U8T Mannosyltransferase ACWT_2296 ENOG4108Z6Z Transcriptional regulator ACWT_2300 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase ACWT_2302 ENOG4105ETE Transcriptional regulator (LacI family ACWT_2304 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component ACWT_2305 ENOG4105DRS transport system, permease ACWT_2306 ENOG4105CJQ hydrolase, family 31 ACWT_2310 ENOG4107QRI Phosphoketolase ACWT_2312 ENOG4108JJB ABC transporter ACWT_2315 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) ACWT_2316 ENOG4105BZU Histidine kinase ACWT_2319 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_2320 ENOG4105BZU Histidine kinase ACWT_2321 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ACWT_2324 ENOG4105CNN ABC, transporter ACWT_2325 ENOG4105CNN ABC, transporter ACWT_2326 ENOG4105C2J ABC transporter ACWT_2327 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ACWT_2331 ENOG4108MWI inositol mono-phosphatase ACWT_2332 ENOG4108DT4 serine threonine protein kinase ACWT_2334 ENOG4105CSW GntR family transcriptional regulator ACWT_2335 ENOG4105C26 Dehydrogenase ACWT_2336 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ACWT_2337 ENOG4105C26 Dehydrogenase ACWT_2338 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACWT_2339 ENOG4107RUE extracellular solute-binding protein family 1 ACWT_2340 ENOG4105F38 ABC transporter, permease ACWT_2341 ENOG4105D38 putrescine abc transporter ACWT_2342 ENOG4105CJP fad dependent oxidoreductase ACWT_2343 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ACWT_2344 ENOG4108Z4X TRANSCRIPTIONal ACWT_2348 ENOG4105CJP fad dependent oxidoreductase ACWT_2349 ENOG4105EW9 transcriptional regulator AsnC family ACWT_2351 ENOG4105C26 Dehydrogenase ACWT_2352 ENOG4108MJI response regulator ACWT_2353 ENOG4107QK4 glycoside hydrolase, family 3 domain protein ACWT_2355 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ACWT_2357 ENOG4105ETE Transcriptional regulator (LacI family ACWT_2358 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ACWT_2359 ENOG4105E6M Sulphatase-modifying factor protein ACWT_2362 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_2363 ENOG4105KXX peptidase s58 dmpa ACWT_2367 ENOG4105ECR NmrA family ACWT_2368 ENOG4105KVH Transcriptional regulator ACWT_2371 ENOG4105BZU Histidine kinase ACWT_2373 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ACWT_2374 ENOG4105CHU acetyl-coa acetyltransferase ACWT_2375 ENOG4105C1G acyl-Coa dehydrogenase ACWT_2379 ENOG4107QKA exodeoxyribonuclease V beta ACWT_2379 ENOG4107QKA exodeoxyribonuclease V beta ACWT_2386 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_2388 ENOG4105BZU Histidine kinase ACWT_2389 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ACWT_2392 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACWT_2393 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACWT_2396 ENOG4105CPU Monooxygenase ACWT_2398 ENOG4105DEN Luciferase family ACWT_2404 ENOG4105CV8 reductase ACWT_2413 ENOG4105EAB amino acid AbC transporter ACWT_2414 ENOG4105CDA abc transporter atp-binding protein ACWT_2415 ENOG4105E5Q amino acid AbC transporter ACWT_2416 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ACWT_2417 ENOG4106FTQ Taurine ABC transporter, periplasmic ACWT_2419 ENOG4105BZU Histidine kinase ACWT_2420 ENOG4105CG3 alpha amylase, catalytic region ACWT_2422 ENOG4108J08 Csbd family ACWT_2423 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) ACWT_2424 ENOG4105EYF MMPL domain protein ACWT_2428 ENOG4105BZ1 (ABC) transporter ACWT_2431 ENOG4105BZN citrate synthase ACWT_2434 ENOG4107TTQ Alpha beta hydrolase fold ACWT_2442 ENOG4108IFG nitrite reductase, (NAD(P)H) ACWT_2443 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit ACWT_2444 ENOG4105DQQ Major facilitator superfamily MFS_1 ACWT_2449 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ACWT_2450 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_2451 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component ACWT_2452 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component ACWT_2453 ENOG4105EPJ extracellular solute-binding protein family 1 ACWT_2454 ENOG4105C6Y Udp-glucose 6-dehydrogenase ACWT_2456 ENOG4105CYP glycoside hydrolase, family ACWT_2459 ENOG4107RTD sua5 ycio yrdc ywlc family protein ACWT_2460 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ACWT_2463 ENOG4105DFW ABC transporter ACWT_2464 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ACWT_2466 ENOG4105EYF MMPL domain protein ACWT_2467 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ACWT_2468 ENOG4105CQB FAD linked oxidase domain protein ACWT_2469 ENOG4105CQB FAD linked oxidase domain protein ACWT_2471 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ACWT_2474 ENOG4105C9U ATP-dependent DNA helicase RecQ ACWT_2476 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ACWT_2480 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_2484 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ACWT_2490 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ACWT_2499 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ACWT_2501 ENOG4105C6Z Gluconate ACWT_2505 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACWT_2509 ENOG4105EEI dihydropteroate synthase ACWT_2510 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer ACWT_2512 ENOG4108JJ9 ABC, transporter ACWT_2513 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ACWT_2514 ENOG4105C4M (Ubiquinol oxidase) subunit I ACWT_2516 ENOG4105D0M Protease HtpX homolog ACWT_2517 ENOG4105Z8B NlpC/P60 family ACWT_2518 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACWT_2523 ENOG4105FDP GntR family transcriptional regulator ACWT_2524 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ACWT_2525 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ACWT_2527 ENOG4105ETX regulatoR ACWT_2528 ENOG41062D9 Histidine kinase ACWT_2534 ENOG41065HY 1,4-beta-cellobiosidase ACWT_2535 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) ACWT_2537 ENOG4105EX0 alpha-galactosidase ACWT_2538 ENOG4107SYN Glycosyl hydrolases family 43 ACWT_2551 ENOG4105BZU Histidine kinase ACWT_2552 ENOG4105DAA L-lactate ACWT_2553 ENOG4105CI2 imidazolone-5-propionate hydrolase ACWT_2555 ENOG4105D5G Transposase ACWT_2567 ENOG4105EDW glycosyl transferase, family 39 ACWT_2568 ENOG4107QP8 phosphohexose isomerase ACWT_2572 ENOG4108UGD Serine Threonine protein kinase ACWT_2574 ENOG4108UZX fmn reductase ACWT_2579 ENOG4107Z3H Transcriptional regulator, TetR family ACWT_2581 ENOG410814C multidrug resistance protein ACWT_2587 ENOG4105EHU Circadian clock protein KaiC ACWT_2588 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_2592 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACWT_2593 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACWT_2594 ENOG4105C3U ABC transporter ACWT_2595 ENOG4108JQ7 (ABC) transporter ACWT_2600 ENOG4105DKQ ROK family ACWT_2605 ENOG41060NJ transcriptional regulator ACWT_2606 ENOG4107QK4 glycoside hydrolase, family 3 domain protein ACWT_2607 ENOG4108ZM9 phosphoglycerate mutase ACWT_2614 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_2615 ENOG4105BZU Histidine kinase ACWT_2617 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_2618 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_2623 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ACWT_2625 ENOG4105D7K pfkb domain protein ACWT_2626 ENOG4105DH8 myo-inositol catabolism ACWT_2627 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) ACWT_2628 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) ACWT_2630 ENOG4105CNN ABC, transporter ACWT_2631 ENOG4105C2J ABC transporter ACWT_2632 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ACWT_2635 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit ACWT_2636 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit ACWT_2637 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit ACWT_2638 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit ACWT_2639 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ACWT_2640 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_2643 ENOG4105C0H protease ACWT_2644 ENOG4105BZ1 (ABC) transporter ACWT_2645 ENOG4107RN3 metallophosphoesterase ACWT_2651 ENOG4107TPY serine threonine protein kinase ACWT_2652 ENOG4105CUB amino acid ACWT_2655 ENOG4106A3M Cytochrome p-450 ACWT_2657 ENOG4105CPF Cell wall formation (By similarity) ACWT_2661 ENOG4105BZU Histidine kinase ACWT_2663 ENOG4105C0D helicase ACWT_2664 ENOG4107XWB Zinc finger, swim domain protein ACWT_2670 ENOG4107XFJ UPF0246 protein ACWT_2672 ENOG4105VZ8 Transcriptional regulator ACWT_2677 ENOG4105BZU Histidine kinase ACWT_2679 ENOG4105CT1 (ABC) transporter ACWT_2683 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ACWT_2685 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ACWT_2693 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACWT_2698 ENOG4105CPC Aldo Keto reductase ACWT_2712 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 ACWT_2714 ENOG4105VF7 tolerance protein ACWT_2716 ENOG4105DGI Alkaline phosphatase ACWT_2720 ENOG4105BZU Histidine kinase ACWT_2721 ENOG4107T8P acyl-Coa dehydrogenase ACWT_2723 ENOG4105BZU Histidine kinase ACWT_2724 ENOG4105FBN Acid phosphatase ACWT_2730 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ACWT_2731 ENOG4105HFS 5'-3' exonuclease ACWT_2732 ENOG4105C1G acyl-Coa dehydrogenase ACWT_2733 ENOG4105J0Q Transcriptional regulator ACWT_2740 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ACWT_2741 ENOG4105FRY Dehydrogenase ACWT_2742 ENOG4105EFZ amidohydrolase ACWT_2743 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit ACWT_2744 ENOG4107CHF 5,6-aminomutase beta subunit ACWT_2745 ENOG4108UYI beta-alanyl-CoA ammonia lyase ACWT_2748 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) ACWT_2750 ENOG4105Q70 ACWT_2757 ENOG4105NPE arsR family transcriptional regulator ACWT_2760 ENOG4108DBC nitroreductase ACWT_2763 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_2766 ENOG4107RNG ABC transporter ACWT_2767 ENOG4105DFW ABC transporter ACWT_2769 ENOG4105C7W Xanthine dehydrogenase ACWT_2770 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding ACWT_2771 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit ACWT_2775 ENOG4105BZU Histidine kinase ACWT_2777 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ACWT_2782 ENOG4108NVR Methyl-accepting chemotaxis ACWT_2783 ENOG4108Z0Z intracellular protease Pfpi family ACWT_2788 ENOG4105C5H ABC transporter ACWT_2790 ENOG4107RSM transcriptional regulator ACWT_2791 ENOG4105CHU acetyl-coa acetyltransferase ACWT_2793 ENOG4107QNJ CoA-transferase subunit B ACWT_2794 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) ACWT_2796 ENOG4105C32 Amino acid ABC transporter (Permease) ACWT_2797 ENOG4108IV0 ABC, transporter ACWT_2798 ENOG4105C0Z ABC transporter ACWT_2801 ENOG4105EV9 Alpha Beta Hydrolase ACWT_2803 ENOG4105ECQ AraC Family Transcriptional Regulator ACWT_2809 ENOG4107R7A Allophanate hydrolase subunit 2 ACWT_2810 ENOG4105P4J Allophanate hydrolase, subunit 1 ACWT_2816 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_2819 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_2820 ENOG4105BZU Histidine kinase ACWT_2821 ENOG4108PJD permease ACWT_2824 ENOG4105E0Y RtcB Protein ACWT_2827 ENOG4105BZU Histidine kinase ACWT_2836 ENOG4105BZ9 Cytochrome C oxidase, subunit I ACWT_2843 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ACWT_2845 ENOG4108J20 pectate lyase ACWT_2846 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ACWT_2847 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction ACWT_2857 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_2862 ENOG4105BZU Histidine kinase ACWT_2865 ENOG4105CUB amino acid ACWT_2866 ENOG4107SCA Formamidase (EC 3.5.1.49) ACWT_2870 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ACWT_2872 ENOG4105EEM helicase ACWT_2874 ENOG4105CNG UPF0061 protein ACWT_2878 ENOG4108KQ5 Integrase catalytic subunit ACWT_2883 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ACWT_2894 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ACWT_2896 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_2897 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) ACWT_2899 ENOG4105D16 lipopolysaccharide heptosyltransferase i ACWT_2906 ENOG4105D4Y metalloprotease ACWT_2926 ENOG4105KK4 UPF0060 membrane protein ACWT_2928 ENOG4105KD7 acetyltransferase ACWT_2934 ENOG4105CRK lysyL-tRNA synthetase ACWT_2941 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ACWT_2943 ENOG4105BZU Histidine kinase ACWT_2946 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ACWT_2951 ENOG4105EMY transcriptional regulator ACWT_2961 ENOG4105DFW ABC transporter ACWT_2964 ENOG4105D9P serine threonine protein kinase ACWT_2972 ENOG4105D3Q Sugar transferase ACWT_2973 ENOG4105C6Y Udp-glucose 6-dehydrogenase ACWT_2977 ENOG4105F7P transcriptional regulator AsnC family ACWT_2992 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_2995 ENOG4105C7S Dehydrogenase ACWT_2996 ENOG4105CPP Dehydrogenase, E1 component ACWT_2997 ENOG4108JYK Dehydrogenase ACWT_2998 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACWT_3003 ENOG4105J5G Transferase hexapeptide repeat containing protein ACWT_3005 ENOG4105CMR udp-glucose 4-epimerase ACWT_3006 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACWT_3007 ENOG4105ECQ AraC Family Transcriptional Regulator ACWT_3008 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_3011 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ACWT_3012 ENOG4105CH6 catalase ACWT_3014 ENOG4108R6G acetyltransferase ACWT_3015 ENOG4105CQB FAD linked oxidase domain protein ACWT_3020 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ACWT_3021 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ACWT_3028 ENOG4107QX3 carboxylase ACWT_3031 ENOG4105NBR Pectinesterase ACWT_3043 ENOG4105CPU Monooxygenase ACWT_3044 ENOG4105CPU Monooxygenase ACWT_3049 ENOG4105EGE secreted protein ACWT_3053 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 ACWT_3055 ENOG4105C30 Nad-dependent epimerase dehydratase ACWT_3057 ENOG4108ZGX Histidine kinase ACWT_3058 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_3067 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ACWT_3068 ENOG4106KNT transcriptional regulator ACWT_3069 ENOG4105EHZ conserved protein UCP016719 ACWT_3070 ENOG4107QK9 Beta-lactamase ACWT_3079 ENOG4106F60 Histidine kinase ACWT_3080 ENOG4105F44 Two component transcriptional regulator, winged helix family ACWT_3082 ENOG4105DUM transcriptional regulator, lysR family ACWT_3085 ENOG4105E9Z Nad-dependent epimerase dehydratase ACWT_3086 ENOG4105CJ1 ABC, transporter ACWT_3093 ENOG4107QVM von Willebrand factor, type A ACWT_3095 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_3099 ENOG4108IAJ Nad-dependent epimerase dehydratase ACWT_3100 ENOG4105E2K Glycosyl transferase (Group 1 ACWT_3111 ENOG4105BZU Histidine kinase ACWT_3123 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) ACWT_3129 ENOG4108YYH Nadph-dependent fmn reductase ACWT_3130 ENOG4105GRZ Ycii-related protein ACWT_3131 ENOG4105CHP RNA polymerase ACWT_3134 ENOG4105BZU Histidine kinase ACWT_3140 ENOG4105CRK lysyL-tRNA synthetase ACWT_3144 ENOG4105ETX regulatoR ACWT_3145 ENOG41062D9 Histidine kinase ACWT_3146 ENOG4105CPC Aldo Keto reductase ACWT_3154 ENOG4108M15 ABC transporter ACWT_3158 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ACWT_3165 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) ACWT_3166 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN ACWT_3176 ENOG4105BZU Histidine kinase ACWT_3183 ENOG4105CRK lysyL-tRNA synthetase ACWT_3188 ENOG4108VQR secreted hydrolase ACWT_3199 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_3200 ENOG4105BZU Histidine kinase ACWT_3201 ENOG4105ETX regulatoR ACWT_3211 ENOG4105BZU Histidine kinase ACWT_3214 ENOG4105C2C drug resistance transporter, Bcr CflA ACWT_3233 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) ACWT_3234 ENOG4105BZU Histidine kinase ACWT_3246 ENOG4105BZU Histidine kinase ACWT_3248 ENOG4105BZU Histidine kinase ACWT_3249 ENOG4105BZU Histidine kinase ACWT_3251 ENOG4108VYJ response regulator receiver protein ACWT_3255 ENOG4105FBN Acid phosphatase ACWT_3267 ENOG4105BZU Histidine kinase ACWT_3269 ENOG4105BZU Histidine kinase ACWT_3270 ENOG4105BZU Histidine kinase ACWT_3280 ENOG4105CHP RNA polymerase ACWT_3281 ENOG4105BZU Histidine kinase ACWT_3285 ENOG4105ESF Peptidoglycan binding domain protein ACWT_3289 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase ACWT_3295 ENOG4105CFG Acts as a chaperone (By similarity) ACWT_3299 ENOG4105BZU Histidine kinase ACWT_3300 ENOG4105BZU Histidine kinase ACWT_3313 ENOG4105BZU Histidine kinase ACWT_3314 ENOG4105BZU Histidine kinase ACWT_3319 ENOG4105CND Glycosyl transferase, family 2 ACWT_3320 ENOG4105BZU Histidine kinase ACWT_3323 ENOG41082AN stage II sporulation protein ACWT_3324 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_3329 ENOG4107S2Z UPF0761 membrane protein ACWT_3330 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) ACWT_3333 ENOG4105BZU Histidine kinase ACWT_3336 ENOG4105D5G Transposase ACWT_3337 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ACWT_3339 ENOG4105BZU Histidine kinase ACWT_3340 ENOG4105BZU Histidine kinase ACWT_3374 ENOG4105ECP epimerase ACWT_3384 ENOG4105BZU Histidine kinase ACWT_3395 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ACWT_3396 ENOG4105BZU Histidine kinase ACWT_3401 ENOG4108NVR Methyl-accepting chemotaxis ACWT_3404 ENOG4108UV1 cellular component movement ACWT_3405 ENOG4105BZU Histidine kinase ACWT_3406 ENOG4105BZU Histidine kinase ACWT_3408 ENOG4105CXN decarboxylase ACWT_3418 ENOG4105DQ6 Transposase ACWT_3429 ENOG4105BZU Histidine kinase ACWT_3434 ENOG4105BZU Histidine kinase ACWT_3435 ENOG4105BZU Histidine kinase ACWT_3440 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_3450 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_3453 ENOG4105BZU Histidine kinase ACWT_3455 ENOG4105C3M thioredoxin reductase ACWT_3466 ENOG4105MWK D-amino acid dehydrogenase, small subunit ACWT_3467 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ACWT_3468 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) ACWT_3471 ENOG4105F0K SARP family transcriptional regulator ACWT_3475 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) ACWT_3477 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ACWT_3479 ENOG4105E9Z Nad-dependent epimerase dehydratase ACWT_3483 ENOG4105JXB ankyrin repeat-containing protein ACWT_3486 ENOG4105BZU Histidine kinase ACWT_3490 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) ACWT_3495 ENOG4105D9P serine threonine protein kinase ACWT_3498 ENOG4105ETE Transcriptional regulator (LacI family ACWT_3505 ENOG4108IG5 Transcriptional regulator ACWT_3511 ENOG4105CNA YD repeat protein ACWT_3518 ENOG4105BZU Histidine kinase ACWT_3519 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_3524 ENOG4105D3P Mannan endo-1,4-beta-mannosidase ACWT_3526 ENOG4105E2R ROK family ACWT_3529 ENOG41067TZ transcriptional regulator, MarR family ACWT_3530 ENOG4105BZP glycoside hydrolase 15-related ACWT_3531 ENOG4105BZU Histidine kinase ACWT_3532 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) ACWT_3533 ENOG4105BZU Histidine kinase ACWT_3538 ENOG4105CJ1 ABC, transporter ACWT_3539 ENOG4108JPW Aminotransferase ACWT_3542 ENOG4108PVU Nucleotidyl transferase ACWT_3545 ENOG410667J hydrolase ACWT_3547 ENOG4108U3T pfkb domain protein ACWT_3548 ENOG4108YUY ACWT_3550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ACWT_3551 ENOG41064E2 Xylose isomerase-like TIM barrel ACWT_3552 ENOG4108KK4 3-dehydroquinate synthase ACWT_3553 ENOG4105C1B dTDP-glucose 4-6-dehydratase ACWT_3557 ENOG4105I1K ABC transporter ACWT_3562 ENOG4105ECR NmrA family ACWT_3563 ENOG4105KVH Transcriptional regulator ACWT_3579 ENOG4105BZU Histidine kinase ACWT_3581 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_3582 ENOG4105DIH basic membrane ACWT_3583 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ACWT_3588 ENOG41082SX arsR family transcriptional regulator ACWT_3603 ENOG4105CE1 Ferrous iron transport protein b ACWT_3604 ENOG4105VEQ Cold shock protein ACWT_3607 ENOG4108NNZ chitinase ACWT_3608 ENOG4106UDK Cellulose-binding, family II ACWT_3613 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_3614 ENOG4105BZU Histidine kinase ACWT_3615 ENOG4105EYF MMPL domain protein ACWT_3632 ENOG4107TE5 Lipid kinase ACWT_3645 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ACWT_3651 ENOG4105BZU Histidine kinase ACWT_3652 ENOG4108Q50 Histidine kinase ACWT_3655 ENOG4105E5Q amino acid AbC transporter ACWT_3662 ENOG4105BZU Histidine kinase ACWT_3665 ENOG4105Y3U Transglycosylase-associated protein ACWT_3675 ENOG4108JQ6 ABC transporter ACWT_3680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACWT_3689 ENOG4105BZU Histidine kinase ACWT_3693 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ACWT_3717 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ACWT_3718 ENOG4107DB1 DUF218 domain ACWT_3719 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ACWT_3721 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_3722 ENOG4105BZU Histidine kinase ACWT_3726 ENOG4105BZU Histidine kinase ACWT_3730 ENOG4105BZU Histidine kinase ACWT_3738 ENOG4105D7K pfkb domain protein ACWT_3739 ENOG4107QKS N-acylglucosamine 2-epimerase ACWT_3740 ENOG41060NJ transcriptional regulator ACWT_3743 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ACWT_3748 ENOG4105BZ1 (ABC) transporter ACWT_3753 ENOG4105NQG DoxX ACWT_3764 ENOG4105EGI Transcriptional regulator ACWT_3768 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ACWT_3772 ENOG4105CHR reductase ACWT_3781 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ACWT_3782 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACWT_3783 ENOG4108K8U Glycerol operon regulatory protein ACWT_3784 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACWT_3785 ENOG4105CHP RNA polymerase ACWT_3786 ENOG4105GRZ Ycii-related protein ACWT_3788 ENOG4105CT3 Monooxygenase ACWT_3813 ENOG4105BZU Histidine kinase ACWT_3818 ENOG4105EAH synthase ACWT_3819 ENOG4105C57 major facilitator superfamily ACWT_3821 ENOG4105CUB amino acid ACWT_3824 ENOG4105G2Y Transcriptional regulator ACWT_3825 ENOG4108MWI inositol mono-phosphatase ACWT_3832 ENOG4105ECQ AraC Family Transcriptional Regulator ACWT_3839 ENOG4107E6A Cytochrome p-450 ACWT_3844 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) ACWT_3854 ENOG4105DSF transport protein ACWT_3860 ENOG41061ZR Transcriptional regulator ACWT_3862 ENOG41061ZR Transcriptional regulator ACWT_3865 ENOG4105D5Q Arginine ornithine antiporter ACWT_3866 ENOG4105CEU Arginine dihydrolase ACWT_3867 ENOG4105DBV ornithine carbamoyltransferase ACWT_3875 ENOG4105C57 major facilitator superfamily ACWT_3880 ENOG4105CBD Diacylglycerol kinase ACWT_3891 ENOG4105E5D amino acid ACWT_3898 ENOG4105BZU Histidine kinase ACWT_3899 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ACWT_3900 ENOG4105CVJ phosphoglycerate mutase ACWT_3905 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase ACWT_3909 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) ACWT_3916 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein ACWT_3917 ENOG4105MHT Transcriptional regulator, ARSR family ACWT_3919 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_3920 ENOG4105BZU Histidine kinase ACWT_3926 ENOG4107TXC Transcriptional regulator ACWT_3930 ENOG4105BZU Histidine kinase ACWT_3933 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) ACWT_3941 ENOG4107SM8 Adenylate Guanylate cyclase ACWT_3944 ENOG4108IG5 Transcriptional regulator ACWT_3958 ENOG4105KME endoribonuclease L-psp ACWT_3970 ENOG4106R7G Glycoside hydrolase family 5 ACWT_3975 ENOG4107QZ7 Cellulose synthase catalytic subunit ACWT_3990 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACWT_3999 ENOG4105DYW oxidoreductase ACWT_4001 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_4005 ENOG4105DBV ornithine carbamoyltransferase ACWT_4006 ENOG4108JPW Aminotransferase ACWT_4007 ENOG4108S01 response regulator ACWT_4012 ENOG4105NAF rna polymerase sigma factor ACWT_4020 ENOG4105CVK Glutamate decarboxylase ACWT_4023 ENOG4105BZU Histidine kinase ACWT_4030 ENOG4105BZ4 penicillin-binding protein ACWT_4032 ENOG4108SVW integral membrane protein ACWT_4033 ENOG41080R8 Conserved Protein ACWT_4034 ENOG4107QR9 Iron-sulfur cluster binding protein ACWT_4035 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ACWT_4036 ENOG4105ERH Fumarylacetoacetate hydrolase ACWT_4038 ENOG4105C2J ABC transporter ACWT_4039 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane ACWT_4042 ENOG4107EJG GntR family transcriptional regulator ACWT_4045 ENOG4107EJG GntR family transcriptional regulator ACWT_4046 ENOG4105CHR reductase ACWT_4047 ENOG4108NVR Methyl-accepting chemotaxis ACWT_4048 ENOG4105BZU Histidine kinase ACWT_4049 ENOG4105BZU Histidine kinase ACWT_4056 ENOG4107EJG GntR family transcriptional regulator ACWT_4060 ENOG4107EJG GntR family transcriptional regulator ACWT_4061 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ACWT_4062 ENOG4105BZU Histidine kinase ACWT_4063 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_4066 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_4067 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_4072 ENOG41082SX arsR family transcriptional regulator ACWT_4082 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_4085 ENOG4105JVQ RNA Polymerase ACWT_4090 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_4094 ENOG4105GRZ Ycii-related protein ACWT_4095 ENOG4105CHP RNA polymerase ACWT_4098 ENOG4105EXG Transcriptional regulator ACWT_4107 ENOG4105M4P Tetr family transcriptional regulator ACWT_4110 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_4111 ENOG4105BZU Histidine kinase ACWT_4114 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ACWT_4116 ENOG4105GRZ Ycii-related protein ACWT_4117 ENOG4105CHP RNA polymerase ACWT_4122 ENOG4105DUM transcriptional regulator, lysR family ACWT_4123 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ACWT_4125 ENOG4105VSH 4-oxalocrotonate tautomerase ACWT_4131 ENOG4108Q50 Histidine kinase ACWT_4133 ENOG4108C33 Resolvase ACWT_4136 ENOG4105EMU Dehydrogenase ACWT_4151 ENOG4105CHR reductase ACWT_4156 ENOG4105CHU acetyl-coa acetyltransferase ACWT_4161 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACWT_4167 ENOG4108M15 ABC transporter ACWT_4168 ENOG4105KCT ABC transporter ACWT_4169 ENOG4105BZU Histidine kinase ACWT_4170 ENOG4108S01 response regulator ACWT_4171 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACWT_4173 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACWT_4175 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACWT_4176 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ACWT_4179 ENOG41062IR nudix hydrolase ACWT_4181 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACWT_4182 ENOG4105C5Z peptidase ACWT_4184 ENOG4105DXX methyltransferase ACWT_4198 ENOG4107S5I aldo keto reductase ACWT_4206 ENOG4108S01 response regulator ACWT_4210 ENOG4105DEU major facilitator superfamily ACWT_4216 ENOG4105KPY Small multidrug resistance protein ACWT_4219 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) ACWT_4220 ENOG4105DTA methyltransferase ACWT_4222 ENOG41090KN UPF0303 protein ACWT_4227 ENOG4105K56 Transcriptional regulator ACWT_4228 ENOG4108ZHJ Organic hydroperoxide resistance protein ACWT_4241 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ACWT_4247 ENOG4105BZU Histidine kinase ACWT_4251 ENOG4107S5I aldo keto reductase ACWT_4256 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_4262 ENOG4105EMU Dehydrogenase ACWT_4277 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ACWT_4280 ENOG4105JVQ RNA Polymerase ACWT_4281 ENOG4105CRQ synthase (Component I) ACWT_4283 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ACWT_4284 ENOG4105CPC Aldo Keto reductase ACWT_4287 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_4300 ENOG410650H (LipO)protein ACWT_4301 ENOG4105DBE peroxidase ACWT_4316 ENOG4105CIG ABC transporter ACWT_4320 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 ACWT_4327 ENOG4105C0H protease ACWT_4339 ENOG4105VEQ Cold shock protein ACWT_4340 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ACWT_4342 ENOG4106S2D Transcriptional regulator ACWT_4357 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase ACWT_4359 ENOG4105EAB amino acid AbC transporter ACWT_4360 ENOG4108N3W hemolysin secretion protein ACWT_4374 ENOG4108UKI Enoyl-CoA hydratase ACWT_4377 ENOG4105E39 Enoyl-CoA hydratase ACWT_4378 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACWT_4380 ENOG4107RDB Major Facilitator ACWT_4387 ENOG4105EJQ L-serine dehydratase ACWT_4388 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ACWT_4390 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) ACWT_4395 ENOG4105KVH Transcriptional regulator ACWT_4397 ENOG4108WUH Transcriptional regulator, TetR family ACWT_4406 ENOG4105CJA serine threonine protein kinase ACWT_4409 ENOG4107QJZ Glycosyl transferase, family 2 ACWT_4417 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_4420 ENOG4105BZU Histidine kinase ACWT_4433 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_4439 ENOG4108RYK Nad-dependent epimerase dehydratase ACWT_4445 ENOG4105DYW oxidoreductase ACWT_4459 ENOG4108V1U phospholipid-binding protein ACWT_4467 ENOG4107RA1 nh(3)-dependent nad( ) synthetase ACWT_4470 ENOG41082BM Transcriptional regulator, arsr family ACWT_4472 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACWT_4473 ENOG4105CSW GntR family transcriptional regulator ACWT_4474 ENOG4105BZU Histidine kinase ACWT_4478 ENOG4108W6C Dehydrogenase ACWT_4479 ENOG4105C2M dna polymerase I ACWT_4484 ENOG4105BZU Histidine kinase ACWT_4485 ENOG4105BZU Histidine kinase ACWT_4489 ENOG4108Z6Z Transcriptional regulator ACWT_4496 ENOG4105BZU Histidine kinase ACWT_4499 ENOG4105CPT Alpha beta hydrolase ACWT_4506 ENOG410905P Pyridoxamine 5-phosphate ACWT_4509 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ACWT_4512 ENOG4105CAY ferredoxin--nadp reductase ACWT_4513 ENOG41066UM arsR family transcriptional regulator ACWT_4515 ENOG4108UXE Protein tyrosine phosphatase ACWT_4516 ENOG4105EGE secreted protein ACWT_4526 ENOG4105CTX dehydratase ACWT_4530 ENOG4105ETE Transcriptional regulator (LacI family ACWT_4532 ENOG4107VIJ nudix hydrolase ACWT_4535 ENOG4105VEQ Cold shock protein ACWT_4537 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ACWT_4540 ENOG4105CZA synthase ACWT_4542 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ACWT_4544 ENOG4106NZI LysR family Transcriptional regulator ACWT_4561 ENOG4105DTD Dehydrogenase ACWT_4562 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ACWT_4563 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) ACWT_4572 ENOG4105BZU Histidine kinase ACWT_4573 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_4579 ENOG4105CMR udp-glucose 4-epimerase ACWT_4594 ENOG4105BZU Histidine kinase ACWT_4595 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACWT_4596 ENOG4105BZU Histidine kinase ACWT_4597 ENOG4105CXN decarboxylase ACWT_4601 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ACWT_4603 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase ACWT_4618 ENOG4107SFI Major Facilitator superfamily ACWT_4619 ENOG4108UMI ABC transporter, permease ACWT_4620 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ACWT_4621 ENOG4105D01 (LipO)protein ACWT_4628 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) ACWT_4630 ENOG4105NTW Transcriptional regulator ACWT_4635 ENOG4105DQ4 alcohol dehydrogenase ACWT_4644 ENOG4105VZ8 Transcriptional regulator ACWT_4660 ENOG4105DEN Luciferase family ACWT_4664 ENOG41088YS Glycosyl transferase (Group 1 ACWT_4669 ENOG4105BZU Histidine kinase ACWT_4670 ENOG4105BZU Histidine kinase ACWT_4672 ENOG4107RGC Glycosyl transferase, family 2 ACWT_4673 ENOG4107T8Q Glycosyl transferase (Group 1 ACWT_4675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_4678 ENOG4105BZU Histidine kinase ACWT_4685 ENOG4105BZU Histidine kinase ACWT_4689 ENOG4105E1F short-chain dehydrogenase reductase ACWT_4690 ENOG4105BZU Histidine kinase ACWT_4691 ENOG4108FN7 Aldo keto reductase ACWT_4703 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase ACWT_4705 ENOG4105C8M UPF0272 protein ACWT_4713 ENOG4105C57 major facilitator superfamily ACWT_4717 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_4720 ENOG4107T94 Endo-14-beta-xylanase ACWT_4721 ENOG4105BZU Histidine kinase ACWT_4728 ENOG4105H3G oxidoreductase ACWT_4734 ENOG4107QSN dihydrolipoamide acetyltransferase ACWT_4737 ENOG4105EW9 transcriptional regulator AsnC family ACWT_4743 ENOG4105PMW Domain of unknown function (DUF1990) ACWT_4746 ENOG4105C5W Aldolase ACWT_4748 ENOG4105BZU Histidine kinase ACWT_4757 ENOG4105XYF acetyltransferase ACWT_4760 ENOG4105C57 major facilitator superfamily ACWT_4772 ENOG4105BZU Histidine kinase ACWT_4773 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ACWT_4777 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ACWT_4780 ENOG4105EEF Alkane 1-monooxygenase ACWT_4783 ENOG4107UBC ErfK ybiS ycfS ynhG family protein ACWT_4786 ENOG4105EMN RNA polymerase sigma factor ACWT_4795 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) ACWT_4797 ENOG4105ETE Transcriptional regulator (LacI family ACWT_4805 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ACWT_4806 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ACWT_4815 ENOG4105EXC Acyl-transferase ACWT_4818 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_4825 ENOG4107RSM transcriptional regulator ACWT_4830 ENOG4108IG5 Transcriptional regulator ACWT_4837 ENOG4105ETE Transcriptional regulator (LacI family ACWT_4843 ENOG4105E2D ec 3.2.1.52 ACWT_4846 ENOG4105K8R UPF0145 protein ACWT_4847 ENOG4105K8R UPF0145 protein ACWT_4869 ENOG4108KQ5 Integrase catalytic subunit ACWT_4880 ENOG4105CJ1 ABC, transporter ACWT_4881 ENOG4105CJ1 ABC, transporter ACWT_4894 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACWT_4895 ENOG4105T38 integral membrane protein ACWT_4896 ENOG4105DZ1 carboxypeptidase ACWT_4902 ENOG4105D3W isochorismatase ACWT_4908 ENOG4105GMT ATPase associated with various cellular activities aaa_5 ACWT_4914 ENOG4105BZU Histidine kinase ACWT_4916 ENOG4105KKX ATPase associated with various cellular activities aaa_5 ACWT_4917 ENOG4105DEG Vwa containing coxe family protein ACWT_4927 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ACWT_4933 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ACWT_4934 ENOG4105EB3 Histidine kinase ACWT_4938 ENOG4105CAQ asparagine synthetase ACWT_4939 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ACWT_4943 ENOG4108UW8 fha domain-containing protein ACWT_4953 ENOG4105MHT Transcriptional regulator, ARSR family ACWT_4954 ENOG4107KWJ von Willebrand factor, type A ACWT_4955 ENOG4105EET magnesium chelatase ACWT_4956 ENOG4105JAB phenazine biosynthesis protein, phzf family ACWT_4957 ENOG4105BZU Histidine kinase ACWT_4958 ENOG4105C5H ABC transporter ACWT_4962 ENOG4105F32 YngK protein ACWT_4963 ENOG4107QPH glycogen) synthase ACWT_4965 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ACWT_4966 ENOG4105BZU Histidine kinase ACWT_4970 ENOG4105E09 nadh pyrophosphatase ACWT_4979 ENOG410848D S4 domain protein YaaA ACWT_4983 ENOG4105WN5 stage II sporulation protein ACWT_4984 ENOG4105DKQ ROK family ACWT_4987 ENOG4108HWW ABC transporter ACWT_4988 ENOG4105C2J ABC transporter ACWT_4989 ENOG4105DFW ABC transporter ACWT_4990 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) ACWT_4991 ENOG4105ETE Transcriptional regulator (LacI family ACWT_4994 ENOG41090CE integral membrane protein ACWT_4998 ENOG4105BZU Histidine kinase ACWT_4999 ENOG4107AQZ Membrane ACWT_5000 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_5001 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_5007 ENOG4105BZU Histidine kinase ACWT_5009 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_5010 ENOG4105CBS Chea signal transduction histidine kinase ACWT_5011 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_5012 ENOG4105BZU Histidine kinase ACWT_5013 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_5014 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_5016 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_5019 ENOG4108594 Permease of the drug metabolite transporter ACWT_5028 ENOG4107R9S Malate synthase ACWT_5030 ENOG4105KZX Pterin carbinolamine dehydratase ACWT_5034 ENOG41061MV Arylsulfatase ACWT_5036 ENOG4105YVM Phosphoesterase, PA-phosphatase related ACWT_5037 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ACWT_5040 ENOG4105CSU acyl-Coa dehydrogenase ACWT_5041 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACWT_5043 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACWT_5054 ENOG4108JGH Tetr family transcriptional regulator ACWT_5057 ENOG4105DQ5 transport system permease protein ACWT_5058 ENOG4105TVJ transport system, permease ACWT_5059 ENOG4105E0A ABC, transporter ACWT_5061 ENOG4105D5U fad dependent oxidoreductase ACWT_5063 ENOG4105ETX regulatoR ACWT_5064 ENOG4107EFR Flavocytochrome c ACWT_5065 ENOG4108DEF Globin ACWT_5067 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ACWT_5073 ENOG4105BZU Histidine kinase ACWT_5074 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_5076 ENOG4105CT1 (ABC) transporter ACWT_5086 ENOG4108IQE Amp-dependent synthetase and ligase ACWT_5089 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ACWT_5092 ENOG4105CQR helicase ACWT_5093 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ACWT_5097 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ACWT_5099 ENOG4107TMB Transcriptional regulator ACWT_5108 ENOG4105BZU Histidine kinase ACWT_5111 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) ACWT_5112 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) ACWT_5113 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) ACWT_5114 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) ACWT_5115 ENOG4105E5F proteasome ACWT_5117 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) ACWT_5123 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_5125 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_5126 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_5134 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_5136 ENOG4105C8N cysteinyl-tRNA synthetase ACWT_5140 ENOG4105DYW oxidoreductase ACWT_5141 ENOG4105CPC Aldo Keto reductase ACWT_5142 ENOG4105BZU Histidine kinase ACWT_5146 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ACWT_5156 ENOG4105EC2 ftsk spoIIIe ACWT_5161 ENOG4105NHS Transcriptional regulator, TraR DksA family ACWT_5163 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_5164 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ACWT_5172 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ACWT_5177 ENOG4107YCR Transcriptional regulator, ARSR family ACWT_5182 ENOG4105CGK Exodeoxyribonuclease III ACWT_5188 ENOG4105CQ7 ATP-dependent helicase ACWT_5189 ENOG4108KGH TRANSCRIPTIONal ACWT_5190 ENOG4105ETX regulatoR ACWT_5192 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ACWT_5202 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ACWT_5204 ENOG41068WN ACWT_5206 ENOG4105BZM domain protein ACWT_5215 ENOG41065HY 1,4-beta-cellobiosidase ACWT_5220 ENOG4107YBY Hydrolase ACWT_5221 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ACWT_5223 ENOG4108S01 response regulator ACWT_5224 ENOG4105BZU Histidine kinase ACWT_5225 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ACWT_5231 ENOG4105BZU Histidine kinase ACWT_5232 ENOG4105BZU Histidine kinase ACWT_5234 ENOG4107TPY serine threonine protein kinase ACWT_5235 ENOG4105ETE Transcriptional regulator (LacI family ACWT_5238 ENOG41060NJ transcriptional regulator ACWT_5246 ENOG4108J20 pectate lyase ACWT_5248 ENOG4105CK5 oxidoreductase ACWT_5249 ENOG4105DEI Mannitol dehydrogenase ACWT_5250 ENOG4105D2H Uronic isomerase ACWT_5251 ENOG4105DDC Oxidoreductase domain protein ACWT_5252 ENOG4105ETE Transcriptional regulator (LacI family ACWT_5254 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component ACWT_5255 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component ACWT_5257 ENOG4105EW9 transcriptional regulator AsnC family ACWT_5258 ENOG4105DCF alanine dehydrogenase ACWT_5261 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_5272 ENOG4105F8D glycoside hydrolase family 4 ACWT_5276 ENOG4107UEK pfkb domain protein ACWT_5284 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) ACWT_5286 ENOG4105NAF rna polymerase sigma factor ACWT_5294 ENOG4105XN3 extracellular solute-binding protein family 1 ACWT_5295 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component ACWT_5297 ENOG4105ETE Transcriptional regulator (LacI family ACWT_5302 ENOG4105EYF MMPL domain protein ACWT_5310 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) ACWT_5311 ENOG41062B0 ABC transporter, permease ACWT_5312 ENOG4107R9N ABC transporter ACWT_5313 ENOG4105C2J ABC transporter ACWT_5314 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator ACWT_5315 ENOG4105ETE Transcriptional regulator (LacI family ACWT_5317 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase ACWT_5321 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ACWT_5322 ENOG41060BG Tetr family transcriptional regulator ACWT_5323 ENOG4105C1A potassium transporter peripheral membrane ACWT_5328 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_5331 ENOG4105CJ1 ABC, transporter ACWT_5343 ENOG4105VP0 transcriptional regulator, lysR family ACWT_5344 ENOG4105C26 Dehydrogenase ACWT_5347 ENOG4107VXZ Hydrolase ACWT_5348 ENOG4105JSC dimethylmenaquinone methyltransferase ACWT_5353 ENOG4105I82 acetyl xylan esterase ACWT_5354 ENOG4105C7H Helicase, RecD TraA family ACWT_5357 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_5358 ENOG4108UTZ Dihydroxyacetone kinase ACWT_5359 ENOG4105CMT Dihydroxyacetone kinase ACWT_5360 ENOG4105VDH Dihydroxyacetone kinase ACWT_5365 ENOG4108Z12 YiaAB two helix domain-containing protein ACWT_5366 ENOG4105CHU acetyl-coa acetyltransferase ACWT_5367 ENOG4105CHR reductase ACWT_5372 ENOG4108IND Tetr family transcriptional regulator ACWT_5376 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_5377 ENOG4105C1G acyl-Coa dehydrogenase ACWT_5383 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR ACWT_5384 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase ACWT_5386 ENOG4105E39 Enoyl-CoA hydratase ACWT_5388 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) ACWT_5389 ENOG4105BZU Histidine kinase ACWT_5390 ENOG4105BZU Histidine kinase ACWT_5392 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ACWT_5393 ENOG4105F95 Monooxygenase ACWT_5395 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ACWT_5398 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ACWT_5401 ENOG4105BZU Histidine kinase ACWT_5402 ENOG4105C57 major facilitator superfamily ACWT_5403 ENOG4108JGH Tetr family transcriptional regulator ACWT_5407 ENOG4105BZ4 penicillin-binding protein ACWT_5415 ENOG4105D3Q Sugar transferase ACWT_5416 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACWT_5420 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACWT_5427 ENOG4105CEP NADH dehydrogenase ACWT_5428 ENOG4107W53 thymidine kinase ACWT_5430 ENOG4105BZ1 (ABC) transporter ACWT_5431 ENOG4105BZ1 (ABC) transporter ACWT_5435 ENOG4105CR4 methylisocitrate lyase ACWT_5447 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) ACWT_5448 ENOG4105BZU Histidine kinase ACWT_5452 ENOG4105C4C beta-galactosidase ACWT_5454 ENOG4105I1K ABC transporter ACWT_5456 ENOG4105ETE Transcriptional regulator (LacI family ACWT_5466 ENOG4108W6C Dehydrogenase ACWT_5470 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ACWT_5481 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACWT_5489 ENOG4107EFR Flavocytochrome c ACWT_5492 ENOG4108TCJ secreted hydrolase ACWT_5496 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACWT_5497 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ACWT_5498 ENOG4108K8U Glycerol operon regulatory protein ACWT_5499 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACWT_5507 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACWT_5508 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_5515 ENOG4105BZU Histidine kinase ACWT_5526 ENOG4105D3Q Sugar transferase ACWT_5527 ENOG4107QQG Dehydrogenase ACWT_5532 ENOG4105C0R drug resistance transporter emrb qaca subfamily ACWT_5534 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ACWT_5536 ENOG4105BZU Histidine kinase ACWT_5537 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_5543 ENOG4105ETE Transcriptional regulator (LacI family ACWT_5550 ENOG4105BZU Histidine kinase ACWT_5562 ENOG4105BZ1 (ABC) transporter ACWT_5563 ENOG4105BZ1 (ABC) transporter ACWT_5566 ENOG4108KXV response regulator ACWT_5567 ENOG41065SU Two-component system sensor kinase ACWT_5570 ENOG4108WQH regulatoR ACWT_5573 ENOG4105BZ1 (ABC) transporter ACWT_5576 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) ACWT_5579 ENOG4107YB1 Trehalose corynomycolyl transferase ACWT_5580 ENOG4107TPY serine threonine protein kinase ACWT_5582 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein ACWT_5604 ENOG4105F6U Short-chain dehydrogenase reductase Sdr ACWT_5606 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ACWT_5607 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_5609 ENOG4108RF4 Tetr family transcriptional regulator ACWT_5615 ENOG4105EM7 Selenocysteine-specific translation elongation factor ACWT_5615 ENOG4105EM7 Selenocysteine-specific translation elongation factor ACWT_5616 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) ACWT_5620 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) ACWT_5623 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ACWT_5624 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACWT_5625 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACWT_5638 ENOG4105DUX Transporter ACWT_5701 ENOG4108KQ5 Integrase catalytic subunit ACWT_5702 ENOG4105CDU Replicative dna helicase ACWT_5708 ENOG41082AN stage II sporulation protein ACWT_5712 ENOG4105DBE peroxidase ACWT_5742 ENOG4105CUV Homoserine Kinase ACWT_5777 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_5778 ENOG41062JF Transcriptional regulator ACWT_5779 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACWT_5809 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ACWT_5836 ENOG4105D5G Transposase ACWT_5884 ENOG4105E4C Lytic transglycosylase catalytic ACWT_5887 ENOG4105DHQ Histidine kinase ACWT_5888 ENOG4105ETX regulatoR ACWT_5895 ENOG410836F Transposase ACWT_5896 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) ACWT_5898 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACWT_5899 ENOG4105DUX Transporter ACWT_5902 ENOG4105TIE Aminoglycoside 2'-N-acetyltransferase ACWT_5905 ENOG4105EX0 alpha-galactosidase ACWT_5910 ENOG4106BQ7 Glycosyl Transferase ACWT_5913 ENOG4105XDV ACWT_5927 ENOG4105C57 major facilitator superfamily ACWT_5934 ENOG4105D5G Transposase ACWT_5944 ENOG4105MXW flavin reductase domain protein, FMN-binding ACWT_5951 ENOG4105CHM Aminotransferase ACWT_5952 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ACWT_5958 ENOG4105BZU Histidine kinase ACWT_5961 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component ACWT_5962 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ACWT_5966 ENOG4105EC2 ftsk spoIIIe ACWT_5968 ENOG4107RCC Major Facilitator Superfamily ACWT_5969 ENOG410834F Transcriptional regulator ACWT_5980 ENOG4108RZE Tetr family transcriptional regulator ACWT_5986 ENOG4105D8V Glucose sorbosone dehydrogenase ACWT_6001 ENOG4105BZU Histidine kinase ACWT_6004 ENOG4105EEX Two component transcriptional regulator (Winged helix family ACWT_6007 ENOG4105C0W non-ribosomal peptide synthetase ACWT_6024 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ACWT_6026 ENOG4105C0W non-ribosomal peptide synthetase ACWT_6037 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ACWT_6038 ENOG41084GC stage II sporulation protein ACWT_6049 ENOG4105BZU Histidine kinase ACWT_6057 ENOG4105D9U N-acetyltransferase ACWT_6060 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_6061 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_6062 ENOG4105C0W non-ribosomal peptide synthetase ACWT_6066 ENOG4105CIH Imidazole acetol-phosphate transaminase ACWT_6069 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ACWT_6070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ACWT_6071 ENOG4105BZU Histidine kinase ACWT_6073 ENOG4105BZU Histidine kinase ACWT_6074 ENOG4105BZU Histidine kinase ACWT_6075 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_6088 ENOG4105EIP mannose-6-phosphate isomerase ACWT_6092 ENOG4108JPW Aminotransferase ACWT_6103 ENOG4105CAQ asparagine synthetase ACWT_6106 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_6110 ENOG41079R3 acyl carrier protein ACWT_6111 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ACWT_6117 ENOG4108YUY ACWT_6118 ENOG4108KK4 3-dehydroquinate synthase ACWT_6151 ENOG4105F9F transposase ACWT_6156 ENOG4108KU9 integrase family ACWT_6177 ENOG4106CY5 excisionase ACWT_6179 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ACWT_6180 ENOG4105CAT Cytidine monophosphate kinase ACWT_6182 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACWT_6183 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ACWT_6185 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_6187 ENOG4107YUH hydrolase ACWT_6189 ENOG4105FE9 pseudouridine synthase ACWT_6190 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ACWT_6191 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) ACWT_6199 ENOG4105CHR reductase ACWT_6203 ENOG4105DCF alanine dehydrogenase ACWT_6208 ENOG4105KVH Transcriptional regulator ACWT_6214 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ACWT_6222 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ACWT_6227 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_6229 ENOG4105DSU hydrolase ACWT_6231 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ACWT_6232 ENOG4105CSR polyphosphate kinase 2 ACWT_6234 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ACWT_6235 ENOG410849S phosphocarrier protein (HPr) ACWT_6236 ENOG4105CPQ Dehydrogenase ACWT_6237 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ACWT_6238 ENOG4105CTS PTS system mannitol-specific ACWT_6239 ENOG4105CTS PTS system mannitol-specific ACWT_6240 ENOG4105DE4 1-phosphofructokinase ACWT_6241 ENOG4105E98 transcriptional regulator DeoR family ACWT_6243 ENOG4105C57 major facilitator superfamily ACWT_6244 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ACWT_6249 ENOG4105K4I Scp-like extracellular ACWT_6254 ENOG4108VX5 3-methyladenine DNA glycosylase ACWT_6255 ENOG4105EEM helicase ACWT_6256 ENOG4105E8R UPF0173 metal-dependent hydrolase ACWT_6264 ENOG4107TSN permease ACWT_6265 ENOG4105BZU Histidine kinase ACWT_6267 ENOG4105EG2 ABC transporter, permease ACWT_6268 ENOG4105D56 permease protein ACWT_6270 ENOG4105ETE Transcriptional regulator (LacI family ACWT_6271 ENOG4107R4C succinyl-diaminopimelate desuccinylase ACWT_6272 ENOG4105CH7 arginosuccinase ACWT_6279 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ACWT_6280 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) ACWT_6281 ENOG4105CAS nag kinase ACWT_6282 ENOG4105C8Y Acetylornithine aminotransferase ACWT_6283 ENOG4105DBV ornithine carbamoyltransferase ACWT_6286 ENOG4105CDH Citrulline--aspartate ligase ACWT_6291 ENOG41067HS methyltransferase ACWT_6293 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process ACWT_6295 ENOG4107QK4 glycoside hydrolase, family 3 domain protein ACWT_6300 ENOG4107GZ4 SanA protein ACWT_6301 ENOG4107SCK Monooxygenase ACWT_6308 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ACWT_6309 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ACWT_6310 ENOG4108RWN rrna methyltransferase ACWT_6311 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ACWT_6312 ENOG41084BS 50S ribosomal protein L35 ACWT_6313 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ACWT_6315 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ACWT_6316 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase ACWT_6318 ENOG4105EAD ABC transporter ACWT_6320 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ACWT_6321 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ACWT_6324 ENOG4105C9B Cysteine desulfurase ACWT_6327 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ACWT_6330 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ACWT_6331 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ACWT_6333 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ACWT_6335 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ACWT_6336 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ACWT_6338 ENOG4105SKN orotidine 5''-phosphate decarboxylase ACWT_6339 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ACWT_6340 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ACWT_6342 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ACWT_6343 ENOG4105CD3 dihydroorotase ACWT_6344 ENOG4105CXT aspartate transcarbamylase ACWT_6345 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) ACWT_6347 ENOG410803B Involved in the transcription termination process (By similarity) ACWT_6348 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ACWT_6349 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ACWT_6350 ENOG4105D49 3-dehydroquinate synthase ACWT_6351 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ACWT_6352 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ACWT_6353 ENOG4107YNV 3-dehydroquinate dehydratase ACWT_6354 ENOG4105HHA aminodeoxychorismate lyase ACWT_6356 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ACWT_6357 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ACWT_6369 ENOG4105C9M aspartyl-trna synthetase ACWT_6377 ENOG4105E2D ec 3.2.1.52 ACWT_6379 ENOG41069H0 dihydroorotase EC 3.5.2.3 ACWT_6380 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) ACWT_6381 ENOG4107TPY serine threonine protein kinase ACWT_6382 ENOG4108YZ9 Urea amidohydrolase subunit gamma ACWT_6383 ENOG4105KI2 Urea amidohydrolase subunit beta ACWT_6384 ENOG4105CQM Urea amidohydrolase subunit alpha ACWT_6386 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACWT_6388 ENOG4107TPY serine threonine protein kinase ACWT_6389 ENOG4107RRY Cyanophycin synthetase ACWT_6390 ENOG4105DDG Cyanophycinase ACWT_6391 ENOG4107YPT transcriptional regulator ACWT_6393 ENOG4105CUT histidyl-tRNA synthetase ACWT_6397 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACWT_6398 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ACWT_6401 ENOG4105VIE preprotein translocase, subunit YajC ACWT_6402 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ACWT_6403 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ACWT_6404 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) ACWT_6410 ENOG4105CDY transcriptional regulatory protein ACWT_6411 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) ACWT_6412 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) ACWT_6414 ENOG4105E2K Glycosyl transferase (Group 1 ACWT_6415 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase ACWT_6421 ENOG4105C22 threonyL-tRNA synthetase ACWT_6424 ENOG41065SU Two-component system sensor kinase ACWT_6425 ENOG4105CYP glycoside hydrolase, family ACWT_6427 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ACWT_6428 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) ACWT_6429 ENOG4108FN7 Aldo keto reductase ACWT_6431 ENOG4105VEQ Cold shock protein ACWT_6438 ENOG4105D17 glycoside hydrolase, family 3 domain protein ACWT_6440 ENOG4105C9U ATP-dependent DNA helicase RecQ ACWT_6448 ENOG4105ENE Histidine kinase ACWT_6451 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_6470 ENOG4105ECY inositol monophosphatase ACWT_6471 ENOG4105EUB pirin domain protein ACWT_6472 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACWT_6479 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ACWT_6482 ENOG4107R9S Malate synthase ACWT_6483 ENOG4105VT2 5-hydroxyisourate hydrolase ACWT_6484 ENOG4105CQ7 ATP-dependent helicase ACWT_6485 ENOG4105DXX methyltransferase ACWT_6486 ENOG4105BZU Histidine kinase ACWT_6490 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ACWT_6501 ENOG4107UWA esterase ACWT_6507 ENOG4105BZU Histidine kinase ACWT_6509 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ACWT_6510 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ACWT_6511 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ACWT_6515 ENOG4105CK7 Sodium proline symporter ACWT_6518 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 ACWT_6519 ENOG4105DYW oxidoreductase ACWT_6520 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) ACWT_6521 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone ACWT_6529 ENOG4105DZ1 carboxypeptidase ACWT_6531 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACWT_6532 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) ACWT_6533 ENOG4105EEM helicase ACWT_6535 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACWT_6536 ENOG4105C1J atp-dependent rna helicase ACWT_6543 ENOG4105ETE Transcriptional regulator (LacI family ACWT_6545 ENOG4108JQ7 (ABC) transporter ACWT_6547 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACWT_6548 ENOG4105C3U ABC transporter ACWT_6555 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACWT_6556 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACWT_6557 ENOG4105F8J Adenylate Guanylate cyclase ACWT_6558 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_6560 ENOG41065SU Two-component system sensor kinase ACWT_6561 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_6563 ENOG4108ZT1 Transcriptional regulator ACWT_6564 ENOG4108KTG Membrane protein, drug metabolite transporter ACWT_6566 ENOG4105KKX ATPase associated with various cellular activities aaa_5 ACWT_6569 ENOG4105DEG Vwa containing coxe family protein ACWT_6584 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ACWT_6591 ENOG4108DEF Globin ACWT_6595 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component ACWT_6599 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_6600 ENOG4105BZU Histidine kinase ACWT_6602 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_6604 ENOG4108TCJ secreted hydrolase ACWT_6607 ENOG4108UGD Serine Threonine protein kinase ACWT_6609 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ACWT_6610 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ACWT_6613 ENOG4105D7N magnesium and cobalt transport protein CorA ACWT_6615 ENOG4105DKK Benzoate ACWT_6620 ENOG4105CHM Aminotransferase ACWT_6626 ENOG4105M5P UPF0310 protein ACWT_6629 ENOG4105EJ2 Transcriptional regulator ACWT_6633 ENOG4107S46 esterase, PHB depolymerase ACWT_6636 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACWT_6638 ENOG4105FF5 Membrane ACWT_6649 ENOG4105KF0 sporulation and cell division protein, SsgA ACWT_6655 ENOG4105BZU Histidine kinase ACWT_6662 ENOG410841Q phosphoesterase PA-phosphatase related protein ACWT_6669 ENOG4106NMR serine protease ACWT_6670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_6672 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACWT_6675 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_6676 ENOG4108ZGX Histidine kinase ACWT_6681 ENOG4105D3W isochorismatase ACWT_6683 ENOG4105W1Y Transcriptional regulator ACWT_6686 ENOG4108UHU Aldolase ACWT_6692 ENOG4105CG3 alpha amylase, catalytic region ACWT_6693 ENOG4105CPK Glycosyl transferase (Group 1 ACWT_6694 ENOG4105E2K Glycosyl transferase (Group 1 ACWT_6699 ENOG4105D9R oxidoreductase ACWT_6702 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) ACWT_6703 ENOG4105K5B UPF0225 protein ACWT_6704 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_6708 ENOG4105CG3 alpha amylase, catalytic region ACWT_6711 ENOG4108IJG ABC transporter substrate-binding protein ACWT_6713 ENOG4105CHH sulfate transporter ACWT_6715 ENOG4105C0I Conserved Protein ACWT_6716 ENOG4105CAQ asparagine synthetase ACWT_6718 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACWT_6726 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ACWT_6736 ENOG4105G6Z alkaline phosphatase ACWT_6737 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_6738 ENOG4105BZU Histidine kinase ACWT_6742 ENOG4105CJ1 ABC, transporter ACWT_6743 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ACWT_6750 ENOG4108JP0 extracellular solute-binding protein family 1 ACWT_6751 ENOG4105DQE DNA ligase ACWT_6753 ENOG4105BZU Histidine kinase ACWT_6754 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_6759 ENOG41087EV Hsp20/alpha crystallin family ACWT_6760 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ACWT_6761 ENOG4105VEQ Cold shock protein ACWT_6765 ENOG4108KPJ rna polymerase sigma factor ACWT_6767 ENOG4105CTK cobaltochelatase, cobn subunit ACWT_6768 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ACWT_6769 ENOG41081F0 Precorrin-8x methylmutase ACWT_6772 ENOG4107Y2G Glycosyl transferase (Group 1 ACWT_6773 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_6777 ENOG4105CPK Glycosyl transferase (Group 1 ACWT_6778 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) ACWT_6782 ENOG4105DJ2 Major Facilitator Superfamily ACWT_6785 ENOG4108HMN Caspase domain ACWT_6793 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ACWT_6798 ENOG4105C1G acyl-Coa dehydrogenase ACWT_6817 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ACWT_6826 ENOG4105BZU Histidine kinase ACWT_6828 ENOG4105C3F Signal peptidase i ACWT_6829 ENOG4105BZ1 (ABC) transporter ACWT_6844 ENOG4105D29 Helix-turn-helix type 11 domain protein ACWT_6861 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding ACWT_6862 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase ACWT_6865 ENOG4105BZU Histidine kinase ACWT_6869 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) ACWT_6881 ENOG4105ESP cell wall surface anchor family protein ACWT_6887 ENOG4105ETE Transcriptional regulator (LacI family ACWT_6890 ENOG4105CSU acyl-Coa dehydrogenase ACWT_6894 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_6899 ENOG4107R13 MMPL domain protein ACWT_6906 ENOG4105BZU Histidine kinase ACWT_6907 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ACWT_6910 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ACWT_6911 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ACWT_6912 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ACWT_6918 ENOG4107RH8 nuclease SbcCD subunit D ACWT_6919 ENOG4105EYH Exonuclease ACWT_6932 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ACWT_6947 ENOG4105E0X reductase ACWT_6948 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) ACWT_6949 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ACWT_6950 ENOG4105CS1 NAD(P)H quinone oxidoreductase ACWT_6953 ENOG4107JTW chlorite dismutase ACWT_6954 ENOG4105C1Q protoporphyrinogen oxidase ACWT_6955 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ACWT_6958 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ACWT_6959 ENOG4105CHU acetyl-coa acetyltransferase ACWT_6960 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ACWT_6962 ENOG4106F60 Histidine kinase ACWT_6963 ENOG4105F44 Two component transcriptional regulator, winged helix family ACWT_6967 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ACWT_6968 ENOG4107QJT sodium dicarboxylate symporter ACWT_6970 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ACWT_6971 ENOG4105C0X amino acid ACWT_6972 ENOG4107VEG TrkA-N domain protein ACWT_6977 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ACWT_6985 ENOG4105BZU Histidine kinase ACWT_6987 ENOG4105EN6 Membrane ACWT_6989 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) ACWT_6995 ENOG4105C8Q Methyl-accepting chemotaxis ACWT_6996 ENOG4108VYJ response regulator receiver protein ACWT_6998 ENOG4105CBS Chea signal transduction histidine kinase ACWT_7000 ENOG4105BZU Histidine kinase ACWT_7002 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_7003 ENOG4108V3W Chemotaxis protein, CheW ACWT_7004 ENOG4107SDU Methyl-accepting chemotaxis ACWT_7006 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ACWT_7010 ENOG4105DGU Histone deacetylase ACWT_7015 ENOG4106UW1 Major Facilitator superfamily ACWT_7017 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACWT_7018 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ACWT_7020 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACWT_7022 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ACWT_7024 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ACWT_7025 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ACWT_7026 ENOG4105C99 atpase involved in dna repair ACWT_7029 ENOG4105C7B Threonine dehydratase ACWT_7030 ENOG4108KSA LysR family transcriptional regulator ACWT_7033 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ACWT_7035 ENOG4105CDA abc transporter atp-binding protein ACWT_7036 ENOG4107UBR Extracellular solute-binding protein family 3 ACWT_7037 ENOG4105E5Q amino acid AbC transporter ACWT_7038 ENOG4105DRP amino acid AbC transporter ACWT_7039 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) ACWT_7040 ENOG4105KC9 Modulates RecA activity (By similarity) ACWT_7041 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ACWT_7043 ENOG4108UN4 phage SPO1 DNA polymerase-related protein ACWT_7044 ENOG4105CSW GntR family transcriptional regulator ACWT_7046 ENOG4108NIW Leucine export protein LeuE ACWT_7047 ENOG4105D9P serine threonine protein kinase ACWT_7048 ENOG4107QRT dEAD DEAH box helicase ACWT_7051 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) ACWT_7054 ENOG4105WBV Transcriptional regulator ACWT_7055 ENOG4105CEV competence damage-inducible protein ACWT_7057 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) ACWT_7060 ENOG4107QZI cell division protein FtsK ACWT_7062 ENOG4106T9R serine protease ACWT_7063 ENOG4105CN5 Metallo-Beta-Lactamase ACWT_7064 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACWT_7066 ENOG4105T0Z Conserved Protein ACWT_7067 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ACWT_7069 ENOG4105VEQ Cold shock protein ACWT_7071 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ACWT_7072 ENOG4105C1V Peptidase, M16 ACWT_7073 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ACWT_7074 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ACWT_7076 ENOG4105BZU Histidine kinase ACWT_7077 ENOG4105EEX Two component transcriptional regulator (Winged helix family ACWT_7078 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ACWT_7081 ENOG4105SFS phosphoesterase RecJ domain protein ACWT_7082 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ACWT_7085 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ACWT_7089 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) ACWT_7097 ENOG4108Z86 Glutamine amidotransferase ACWT_7098 ENOG4108Z86 Glutamine amidotransferase ACWT_7100 ENOG4105C26 Dehydrogenase ACWT_7104 ENOG4105RHA ABC transporter, permease ACWT_7105 ENOG4108IUX (ABC) transporter ACWT_7106 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_7107 ENOG4108ZGX Histidine kinase ACWT_7111 ENOG4105ECB domain protein ACWT_7112 ENOG4108JJB ABC transporter ACWT_7114 ENOG4108ZHR arsR family transcriptional regulator ACWT_7117 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ACWT_7118 ENOG4105DZP Membrane-associated zinc metalloprotease ACWT_7123 ENOG4107B57 rieske 2fe-2S domain-containing protein ACWT_7126 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ACWT_7128 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ACWT_7129 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ACWT_7130 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ACWT_7131 ENOG4105CE9 30S ribosomal protein S2 ACWT_7132 ENOG41080R2 UPF0102 protein ACWT_7133 ENOG4105C0P Mg chelatase subunit ChlI ACWT_7138 ENOG4105FDP GntR family transcriptional regulator ACWT_7139 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACWT_7143 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ACWT_7144 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ACWT_7147 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ACWT_7148 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ACWT_7149 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ACWT_7150 ENOG41082KU UPF0109 protein ACWT_7151 ENOG4105K5M 30s ribosomal protein S16 ACWT_7153 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) ACWT_7160 ENOG4105C39 capsular polysaccharide phosphotransferase ACWT_7161 ENOG4107QQG Dehydrogenase ACWT_7163 ENOG4105CKK Glycosyl transferase, family 2 ACWT_7165 ENOG4105EXC Acyl-transferase ACWT_7171 ENOG4105K64 Glycosyl transferase, family 2 ACWT_7172 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ACWT_7183 ENOG4105CPK Glycosyl transferase (Group 1 ACWT_7186 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ACWT_7188 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ACWT_7190 ENOG41084BZ 50S ribosomal protein L32 ACWT_7193 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ACWT_7194 ENOG4106H78 methyltransferase ACWT_7198 ENOG4105DP4 dak2 domain fusion protein ylov ACWT_7199 ENOG4105VB9 50S ribosomal protein l28 ACWT_7200 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ACWT_7204 ENOG4105CPF Cell wall formation (By similarity) ACWT_7207 ENOG4105C28 cystathionine ACWT_7208 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ACWT_7210 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) ACWT_7212 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ACWT_7215 ENOG4105K70 DNA-binding protein ACWT_7216 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ACWT_7219 ENOG4105ERH Fumarylacetoacetate hydrolase ACWT_7220 ENOG4105VZ8 Transcriptional regulator ACWT_7222 ENOG4105CJ1 ABC, transporter ACWT_7226 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ACWT_7227 ENOG4105C22 threonyL-tRNA synthetase ACWT_7228 ENOG4105D9U N-acetyltransferase ACWT_7232 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ACWT_7235 ENOG4105CM2 brancheD-chain amino acid aminotransferase ACWT_7236 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ACWT_7239 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ACWT_7240 ENOG4108ZP8 Acetolactate synthase small subunit ACWT_7242 ENOG4105BZU Histidine kinase ACWT_7243 ENOG4105C01 Dihydroxy-acid dehydratase ACWT_7246 ENOG4105E3B Multicopper oxidase ACWT_7250 ENOG4105ETE Transcriptional regulator (LacI family ACWT_7255 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ACWT_7257 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ACWT_7258 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ACWT_7259 ENOG4105BZU Histidine kinase ACWT_7260 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ACWT_7262 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ACWT_7264 ENOG4105C10 Electron transfer flavoprotein ACWT_7266 ENOG4105VG5 Membrane ACWT_7270 ENOG4105EMN RNA polymerase sigma factor ACWT_7272 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ACWT_7276 ENOG4108RVA ribokinase ACWT_7277 ENOG4105DKW ABC transporter ACWT_7279 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) ACWT_7280 ENOG4105C7I Dehydrogenase ACWT_7282 ENOG41066UZ arginase EC 3.5.3.1 ACWT_7285 ENOG41061H0 Monooxygenase ACWT_7287 ENOG4105DJT lAO AO transport system ATPase ACWT_7288 ENOG4105CHU acetyl-coa acetyltransferase ACWT_7292 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein ACWT_7295 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ACWT_7301 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) ACWT_7304 ENOG4105EC2 ftsk spoIIIe ACWT_7306 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ACWT_7308 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ACWT_7311 ENOG4105JAB phenazine biosynthesis protein, phzf family ACWT_7313 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ACWT_7315 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ACWT_7316 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ACWT_7317 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ACWT_7318 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ACWT_7319 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) ACWT_7320 ENOG4106DE0 ATP synthase ACWT_7321 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) ACWT_7324 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ACWT_7325 ENOG4105CGD Nad-dependent epimerase dehydratase ACWT_7326 ENOG4108176 endoribonuclease L-psp ACWT_7328 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ACWT_7331 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ACWT_7332 ENOG4105BZU Histidine kinase ACWT_7334 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ACWT_7335 ENOG4105VFB Binds the 23S rRNA (By similarity) ACWT_7341 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ACWT_7344 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) ACWT_7345 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ACWT_7347 ENOG4105D6E homoserine dehydrogenase ACWT_7349 ENOG4105C75 arginyL-tRNA synthetase ACWT_7352 ENOG4108WS4 fmn reductase ACWT_7355 ENOG4105DP8 Major facilitator superfamily MFS_1 ACWT_7356 ENOG4108J59 Extracellular solute-binding protein, family 5 ACWT_7358 ENOG4105CV1 Transketolase (EC 2.2.1.1) ACWT_7359 ENOG4107SBK Acetylornithine deacetylase ACWT_7360 ENOG4107TJV N-acetylglutamate semialdehyde dehydrogenase ACWT_7363 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) ACWT_7369 ENOG4105CR4 methylisocitrate lyase ACWT_7371 ENOG4105D9P serine threonine protein kinase ACWT_7375 ENOG4105KVH Transcriptional regulator ACWT_7385 ENOG4106032 Glutathionylspermidine synthase ACWT_7391 ENOG4106UDK Cellulose-binding, family II ACWT_7394 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ACWT_7396 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) ACWT_7399 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ACWT_7401 ENOG4105CIK Amidinotransferase ACWT_7402 ENOG4105C8Y Acetylornithine aminotransferase ACWT_7409 ENOG4105C0H protease ACWT_7410 ENOG4105BZU Histidine kinase ACWT_7411 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACWT_7415 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ACWT_7417 ENOG4105C6K Malic enzyme ACWT_7418 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ACWT_7423 ENOG4108VEQ Superoxide dismutase ACWT_7424 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) ACWT_7425 ENOG4105FDP GntR family transcriptional regulator ACWT_7427 ENOG4105CBD Diacylglycerol kinase ACWT_7430 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ACWT_7434 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ACWT_7436 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit ACWT_7438 ENOG4105EMN RNA polymerase sigma factor ACWT_7441 ENOG4108RAV Conserved protein ACWT_7442 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ACWT_7443 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ACWT_7444 ENOG4107TK4 histidinol-phosphate phosphatase ACWT_7459 ENOG4105DDN Pentapeptide repeat-containing protein ACWT_7466 ENOG4105C57 major facilitator superfamily ACWT_7467 ENOG4105CFF transcriptional regulator ACWT_7469 ENOG4105DJZ UPF0182 protein ACWT_7470 ENOG41063PX domain protein ACWT_7479 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ACWT_7484 ENOG4105E09 nadh pyrophosphatase ACWT_7490 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ACWT_7493 ENOG4105VEQ Cold shock protein ACWT_7496 ENOG4105C4R Atp-dependent dna helicase ACWT_7496 ENOG4105C4R Atp-dependent dna helicase ACWT_7497 ENOG4108URH decarboxylase ACWT_7498 ENOG4108URH decarboxylase ACWT_7501 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) ACWT_7504 ENOG4108Z4X TRANSCRIPTIONal ACWT_7511 ENOG4105PDP Short chain dehydrogenase ACWT_7515 ENOG4108Z4U Ferredoxin ACWT_7516 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ACWT_7519 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) ACWT_7520 ENOG4105C5Z peptidase ACWT_7524 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ACWT_7529 ENOG4105C0Z ABC transporter ACWT_7530 ENOG4108IV0 ABC, transporter ACWT_7532 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ACWT_7534 ENOG4105CHR reductase ACWT_7535 ENOG41061TZ Short-chain dehydrogenase reductase Sdr ACWT_7537 ENOG4105C1G acyl-Coa dehydrogenase ACWT_7543 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_7557 ENOG4105C3G gtp-binding protein ACWT_7560 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ACWT_7564 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ACWT_7569 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ACWT_7571 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ACWT_7572 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ACWT_7578 ENOG4108IAB Phoh family ACWT_7579 ENOG4105VNY Trehalose 6-phosphate phosphatase ACWT_7581 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) ACWT_7582 ENOG4105EMN RNA polymerase sigma factor ACWT_7588 ENOG4105D8K carboxyl transferase ACWT_7595 ENOG4107WR6 Maf-like protein ACWT_7596 ENOG4108JIK carboxylase ACWT_7606 ENOG4107RM1 amidohydrolase ACWT_7607 ENOG4105D5P Methylmalonyl-coA mutase ACWT_7608 ENOG4105D9P serine threonine protein kinase ACWT_7609 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain ACWT_7611 ENOG4105J5G Transferase hexapeptide repeat containing protein ACWT_7617 ENOG4107STW synthase ACWT_7622 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ACWT_7624 ENOG4105C26 Dehydrogenase ACWT_7625 ENOG4105C26 Dehydrogenase ACWT_7631 ENOG4105GWZ Roadblock lc7 family protein ACWT_7633 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ACWT_7639 ENOG4105UIB (ABC) transporter ACWT_7640 ENOG4108JQ9 ABC transporter ACWT_7641 ENOG4105DIH basic membrane ACWT_7646 ENOG4105C31 Tryptophanyl-tRNA synthetase ACWT_7647 ENOG4105CMR udp-glucose 4-epimerase ACWT_7648 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ACWT_7653 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo ACWT_7654 ENOG4105D3Q Sugar transferase ACWT_7655 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ACWT_7656 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ACWT_7658 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ACWT_7660 ENOG41067SE Tetr family transcriptional regulator ACWT_7662 ENOG4105C5H ABC transporter ACWT_7663 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ACWT_7664 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ACWT_7665 ENOG4105F8V Hydrolase, tatD family ACWT_7667 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ACWT_7672 ENOG4108ZJ4 polysaccharide deacetylase ACWT_7676 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACWT_7679 ENOG4105CVM Molybdenum cofactor synthesis domain protein ACWT_7680 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ACWT_7681 ENOG4105BZU Histidine kinase ACWT_7691 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ACWT_7692 ENOG4105DB7 PHP domain protein ACWT_7697 ENOG41080RH Thioredoxin ACWT_7705 ENOG4105JAB phenazine biosynthesis protein, phzf family ACWT_7706 ENOG4105CJW magnesium transporter ACWT_7709 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ACWT_7712 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ACWT_7715 ENOG4108UKI Enoyl-CoA hydratase ACWT_7717 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ACWT_7720 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ACWT_7721 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein ACWT_7722 ENOG4105DQU oxidoreductase, subunit beta ACWT_7723 ENOG4107PBV potassium channel ACWT_7728 ENOG41085W3 Transposase ACWT_7729 ENOG4105D52 delta-aminolevulinic acid dehydratase ACWT_7730 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ACWT_7731 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ACWT_7732 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ACWT_7733 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) ACWT_7736 ENOG4105CEY Amp-dependent synthetase and ligase ACWT_7743 ENOG41062BK proline dehydrogenase ACWT_7745 ENOG4105EY0 Xylose isomerase domain protein TIM barrel ACWT_7750 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ACWT_7754 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACWT_7757 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ACWT_7758 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACWT_7760 ENOG4105BZU Histidine kinase ACWT_7763 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ACWT_7764 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) ACWT_7766 ENOG4105E1Q flagellar hook-associated protein ACWT_7770 ENOG4105MQ3 flagellar protein FliS ACWT_7772 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ACWT_7773 ENOG4108ZC9 flagellar basal-body rod protein flgc ACWT_7774 ENOG41084Q6 flagellar hook-basal body complex protein fliE ACWT_7775 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ACWT_7776 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ACWT_7780 ENOG4105E4C Lytic transglycosylase catalytic ACWT_7784 ENOG4105D7B Flagellar biosynthesis protein flha ACWT_7785 ENOG4105D00 flagellar biosynthetic protein flhB ACWT_7786 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ACWT_7787 ENOG4105CN7 Flagellar biosynthetic protein FliP ACWT_7789 ENOG4105DD5 Flagellar motor switch protein ACWT_7790 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ACWT_7792 ENOG4105ER2 Ompa motb domain protein ACWT_7793 ENOG4105E14 MotA TolQ exbB proton channel ACWT_7795 ENOG4105BZE flagellar hook protein, FlgE ACWT_7798 ENOG4108VYJ response regulator receiver protein ACWT_7801 ENOG4105BZU Histidine kinase ACWT_7802 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ACWT_7805 ENOG4105CBS Chea signal transduction histidine kinase ACWT_7806 ENOG4108KXV response regulator ACWT_7807 ENOG4105K4I Scp-like extracellular ACWT_7808 ENOG4107R4N Cell wall formation (By similarity) ACWT_7811 ENOG4105ETE Transcriptional regulator (LacI family ACWT_7821 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ACWT_7822 ENOG41090R7 Ferric uptake ACWT_7825 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands ACWT_7831 ENOG4108KPJ rna polymerase sigma factor ACWT_7837 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ACWT_7838 ENOG4105E2Z phosphate ABC transporter (Permease ACWT_7841 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ACWT_7842 ENOG4107NHD transcriptional regulator ACWT_7845 ENOG4105KHC sulfurtransferase ACWT_7846 ENOG4105PKJ carbohydrate binding ACWT_7849 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) ACWT_7855 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ACWT_7858 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ACWT_7860 ENOG4105CJ1 ABC, transporter ACWT_7861 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACWT_7864 ENOG4105CJ1 ABC, transporter ACWT_7865 ENOG4105E98 transcriptional regulator DeoR family ACWT_7867 ENOG4105DKQ ROK family ACWT_7868 ENOG4105CE4 GlcNAc 6-P deacetylase ACWT_7869 ENOG4105CJ1 ABC, transporter ACWT_7872 ENOG4105WH1 Two component transcriptional regulator luxr family ACWT_7888 ENOG4105C2N RNA methyltransferase TrmH family group 3 ACWT_7889 ENOG4105C8N cysteinyl-tRNA synthetase ACWT_7890 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACWT_7891 ENOG4105C9Q fumarate hydratase class II ACWT_7894 ENOG4107GFK fumarate ACWT_7897 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase ACWT_7899 ENOG4105CIH Imidazole acetol-phosphate transaminase ACWT_7901 ENOG4107TFG D-allose kinase ACWT_7905 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ACWT_7906 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ACWT_7911 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ACWT_7914 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ACWT_7915 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) ACWT_7920 ENOG4105CEN a g-specific adenine glycosylase ACWT_7925 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACWT_7926 ENOG4105RFA Lsr2-like protein ACWT_7927 ENOG4105CRK lysyL-tRNA synthetase ACWT_7928 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) ACWT_7930 ENOG4108IYU L-aspartate oxidase ACWT_7932 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) ACWT_7933 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ACWT_7936 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACWT_7939 ENOG4105E90 ABC transporter ACWT_7940 ENOG4105R40 Glycine betaine carnitine choline ACWT_7941 ENOG4108IJ8 ABC transporter ACWT_7953 ENOG4105E4C Lytic transglycosylase catalytic ACWT_7955 ENOG4105EC2 ftsk spoIIIe ACWT_7958 ENOG4105EUJ GTP cyclohydrolase i ACWT_7959 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACWT_7961 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ACWT_7964 ENOG4105F0N pyrophosphate phospho-hydrolase ACWT_7966 ENOG4105EC2 ftsk spoIIIe ACWT_7967 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACWT_7969 ENOG4105P8F nudix hydrolase ACWT_7970 ENOG4107QX9 Thiol disulfide interChange protein ACWT_7972 ENOG4105PNM synthesis protein ACWT_7975 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ACWT_7977 ENOG4105F8J Adenylate Guanylate cyclase ACWT_7984 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) ACWT_7985 ENOG4108JQC penicillin-binding protein 1A ACWT_7986 ENOG4105KTH gatB Yqey ACWT_7987 ENOG4105DIN metallophosphoesterase ACWT_7989 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ACWT_7991 ENOG4105CFH Aspartokinase ACWT_7993 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ACWT_7996 ENOG4108JQ7 (ABC) transporter ACWT_7997 ENOG4105C3U ABC transporter ACWT_8001 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ACWT_8006 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ACWT_8007 ENOG4108Z6B deaminase ACWT_8011 ENOG4105EVN Prephenate dehydrogenase ACWT_8013 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) ACWT_8014 ENOG4105D0M Protease HtpX homolog ACWT_8015 ENOG4105DCG PHP domain protein ACWT_8018 ENOG4105DHQ Histidine kinase ACWT_8019 ENOG4105GWZ Roadblock lc7 family protein ACWT_8029 ENOG4108NNZ chitinase ACWT_8032 ENOG4105BZU Histidine kinase ACWT_8041 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) ACWT_8043 ENOG4105C8V SAICAR synthetase ACWT_8047 ENOG41065SU Two-component system sensor kinase ACWT_8051 ENOG4105VKD bioY protein ACWT_8056 ENOG4105CPC Aldo Keto reductase ACWT_8059 ENOG4105CJ1 ABC, transporter ACWT_8066 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACWT_8068 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ACWT_8070 ENOG4107104 thymidine kinase ACWT_8072 ENOG4105CFG Acts as a chaperone (By similarity) ACWT_8079 ENOG4105DZ6 Band 7 protein ACWT_8083 ENOG4108NNZ chitinase ACWT_8084 ENOG4105BZU Histidine kinase ACWT_8090 ENOG4108Z6Z Transcriptional regulator ACWT_8098 ENOG41084GC stage II sporulation protein ACWT_8101 ENOG4108KQ5 Integrase catalytic subunit ACWT_8103 ENOG4105DQ6 Transposase ACWT_8122 ENOG4108V1U phospholipid-binding protein ACWT_8129 ENOG4108Z4X TRANSCRIPTIONal ACWT_8138 ENOG4105D7N magnesium and cobalt transport protein CorA ACWT_8141 ENOG4105DCT glycerol dehydrogenase ACWT_8144 ENOG4105E2K Glycosyl transferase (Group 1 ACWT_8146 ENOG4105D3Q Sugar transferase ACWT_8148 ENOG4108HRK Histidine kinase ACWT_8151 ENOG4105EB3 Histidine kinase ACWT_8155 ENOG4106SPC secreted protein ACWT_8162 ENOG4107QN1 sodium solute ACWT_8166 ENOG4105BZU Histidine kinase ACWT_8168 ENOG4105CEU Arginine dihydrolase ACWT_8175 ENOG4108Z9K Osmotically inducible protein ACWT_8177 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ACWT_8178 ENOG4105J7I hydrolase ACWT_8179 ENOG410667J hydrolase ACWT_8180 ENOG4108VC7 Protein of unknown function (DUF2587) ACWT_8181 ENOG4105CIK Amidinotransferase ACWT_8185 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ACWT_8186 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ACWT_8190 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ACWT_8192 ENOG4107RN3 metallophosphoesterase ACWT_8193 ENOG4105C4R Atp-dependent dna helicase ACWT_8201 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ACWT_8202 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ACWT_8209 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ACWT_8210 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ACWT_8211 ENOG4107YH6 single-stranded DNA-binding protein ACWT_8212 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) ACWT_8217 ENOG4105BZ4 penicillin-binding protein ACWT_8220 ENOG4105CZA synthase ACWT_8238 ENOG4105C3M thioredoxin reductase ACWT_8239 ENOG4105K63 Thioredoxin ACWT_8240 ENOG4108E1C hydrolase ACWT_8242 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACWT_8243 ENOG4105CPF Cell wall formation (By similarity) ACWT_8247 ENOG4107QJE Chromosome Partitioning Protein ACWT_8248 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ACWT_8250 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ACWT_8251 ENOG4107MT9 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ACWT_8252 ENOG41084CH 50S ribosomal protein l34