locus-tag	class	description
ACWT_0002	COG0592	DNA-directed DNA polymerase activity
ACWT_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACWT_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACWT_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ACWT_0008	COG0187	DNA topoisomerase II activity
ACWT_0009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACWT_0014	COG2197	response regulator
ACWT_0015	COG4585	Histidine kinase
ACWT_0021	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACWT_0026	COG0326	Molecular chaperone. Has ATPase activity
ACWT_0029	COG0439	Biotin carboxylase
ACWT_0030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACWT_0033	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACWT_0034	COG1960	acyl-CoA dehydrogenase activity
ACWT_0036	COG1846	Transcriptional regulator
ACWT_0044	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACWT_0045	COG1716	ATPase activity
ACWT_0045	COG1716	ATPase activity
ACWT_0046	COG1716	ATPase activity
ACWT_0049	COG0768	penicillin binding
ACWT_0050	COG0515	serine threonine protein kinase
ACWT_0051	COG2815	serine threonine protein kinase
ACWT_0051	COG0515	serine threonine protein kinase
ACWT_0057	COG2181	nitrate reductase activity
ACWT_0057	COG0247	lactate metabolic process
ACWT_0062	COG0717	Belongs to the dCTP deaminase family
ACWT_0065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACWT_0066	COG2770	Histidine kinase
ACWT_0066	COG2208	phosphoserine phosphatase activity
ACWT_0068	COG1960	acyl-CoA dehydrogenase activity
ACWT_0078	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACWT_0079	COG0022	dehydrogenase e1 component
ACWT_0085	COG0443	Heat shock 70 kDa protein
ACWT_0086	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACWT_0087	COG0484	heat shock protein binding
ACWT_0088	COG0789	Transcriptional regulator
ACWT_0092	COG2814	Major facilitator Superfamily
ACWT_0093	COG0542	response to heat
ACWT_0097	COG0640	Transcriptional regulator
ACWT_0099	COG0586	Pfam SNARE associated Golgi protein
ACWT_0100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACWT_0111	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACWT_0112	COG0151	Belongs to the GarS family
ACWT_0115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACWT_0116	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACWT_0117	COG0047	phosphoribosylformylglycinamidine synthase activity
ACWT_0118	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACWT_0122	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACWT_0123	COG0641	radical SAM
ACWT_0130	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ACWT_0138	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ACWT_0143	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACWT_0146	COG0515	serine threonine protein kinase
ACWT_0147	COG1595	DNA-templated transcription, initiation
ACWT_0149	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACWT_0150	COG1121	(ABC) transporter
ACWT_0151	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACWT_0153	COG0640	Transcriptional regulator
ACWT_0154	COG0701	Predicted permease
ACWT_0164	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACWT_0185	COG1971	Probably functions as a manganese efflux pump
ACWT_0190	COG5002	protein histidine kinase activity
ACWT_0197	COG1902	pentaerythritol trinitrate reductase activity
ACWT_0209	COG1131	(ABC) transporter
ACWT_0211	COG0671	phosphoesterase, PA-phosphatase related
ACWT_0212	COG0745	RESPONSE REGULATOR receiver
ACWT_0213	COG2205	protein histidine kinase activity
ACWT_0218	COG0741	lytic transglycosylase activity
ACWT_0218	COG1196	nuclear chromosome segregation
ACWT_0218	COG0739	heme binding
ACWT_0221	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACWT_0236	COG0438	transferase activity, transferring glycosyl groups
ACWT_0239	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACWT_0244	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_0247	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_0248	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACWT_0257	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACWT_0260	COG1136	(ABC) transporter
ACWT_0264	COG0745	RESPONSE REGULATOR receiver
ACWT_0265	COG2205	protein histidine kinase activity
ACWT_0265	COG0784	Response regulator, receiver
ACWT_0267	COG2172	sigma factor antagonist activity
ACWT_0268	COG1366	Belongs to the anti-sigma-factor antagonist family
ACWT_0269	COG1366	Belongs to the anti-sigma-factor antagonist family
ACWT_0271	COG1970	mechanosensitive ion channel activity
ACWT_0280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACWT_0281	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACWT_0283	COG2205	protein histidine kinase activity
ACWT_0283	COG0784	Response regulator, receiver
ACWT_0284	COG0745	RESPONSE REGULATOR receiver
ACWT_0288	COG1366	Belongs to the anti-sigma-factor antagonist family
ACWT_0289	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACWT_0290	COG0406	alpha-ribazole phosphatase activity
ACWT_0291	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACWT_0292	COG0785	Cytochrome C biogenesis protein
ACWT_0294	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACWT_0296	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACWT_0298	COG0163	prenyltransferase activity
ACWT_0303	COG0513	Belongs to the DEAD box helicase family
ACWT_0305	COG0791	NLP P60 protein
ACWT_0305	COG3883	PFAM NLP P60 protein
ACWT_0306	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACWT_0310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACWT_0311	COG1120	ATPase activity
ACWT_0317	COG3973	AAA domain
ACWT_0320	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACWT_0321	COG0667	Aldo Keto reductase
ACWT_0322	COG4279	zinc finger
ACWT_0323	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACWT_0326	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACWT_0327	COG2226	methyltransferase
ACWT_0331	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_0332	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_0333	COG0649	NAD binding
ACWT_0336	COG1034	ATP synthesis coupled electron transport
ACWT_0337	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACWT_0338	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_0339	COG0839	Belongs to the complex I subunit 6 family
ACWT_0340	COG0713	ATP synthesis coupled electron transport
ACWT_0343	COG1007	ATP synthesis coupled electron transport
ACWT_0348	COG1950	PFAM Membrane protein of
ACWT_0355	COG0596	Alpha beta hydrolase
ACWT_0357	COG4412	M6 family metalloprotease domain protein
ACWT_0357	COG3291	Pkd domain containing protein
ACWT_0358	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACWT_0369	COG1111	helicase
ACWT_0369	COG1205	dead DEAH box helicase
ACWT_0370	COG1366	Belongs to the anti-sigma-factor antagonist family
ACWT_0372	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACWT_0375	COG1754	DNA topoisomerase type I activity
ACWT_0375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACWT_0377	COG1309	transcriptional regulator
ACWT_0379	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACWT_0381	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACWT_0387	COG1774	PSP1 C-terminal conserved region
ACWT_0392	COG1404	Belongs to the peptidase S8 family
ACWT_0395	COG0738	Major facilitator superfamily
ACWT_0404	COG1793	dna ligase
ACWT_0404	COG3285	dna ligase
ACWT_0406	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACWT_0411	COG1061	Type III restriction enzyme res subunit
ACWT_0414	COG1278	Cold shock
ACWT_0415	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACWT_0421	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACWT_0422	COG2814	Major facilitator Superfamily
ACWT_0424	COG2814	Major facilitator Superfamily
ACWT_0427	COG2252	PERMEase
ACWT_0428	COG1846	Transcriptional regulator
ACWT_0429	COG2814	Major facilitator Superfamily
ACWT_0431	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ACWT_0433	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACWT_0435	COG0259	pyridoxamine-phosphate oxidase activity
ACWT_0437	COG2017	converts alpha-aldose to the beta-anomer
ACWT_0443	COG3842	ATPase activity
ACWT_0449	COG1134	teichoic acid transport
ACWT_0449	COG1388	LysM domain
ACWT_0451	COG1309	transcriptional regulator
ACWT_0456	COG0477	Major facilitator Superfamily
ACWT_0465	COG0745	RESPONSE REGULATOR receiver
ACWT_0466	COG0604	alcohol dehydrogenase
ACWT_0467	COG3850	Histidine kinase
ACWT_0468	COG2197	response regulator
ACWT_0470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACWT_0471	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACWT_0472	COG5001	Diguanylate cyclase
ACWT_0472	COG3300	MHYT domain
ACWT_0474	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACWT_0479	COG0596	Alpha beta hydrolase
ACWT_0480	COG2119	membrane
ACWT_0484	COG0477	Major facilitator Superfamily
ACWT_0491	COG0586	Pfam SNARE associated Golgi protein
ACWT_0494	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACWT_0502	COG1309	transcriptional regulator
ACWT_0503	COG1131	(ABC) transporter
ACWT_0504	COG3559	Exporter of polyketide antibiotics
ACWT_0507	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACWT_0510	COG3795	YCII-related domain
ACWT_0511	COG4941	Belongs to the sigma-70 factor family
ACWT_0512	COG0840	transmembrane signaling receptor activity
ACWT_0515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACWT_0516	COG2271	Major facilitator Superfamily
ACWT_0524	COG2971	BadF BadG BcrA BcrD
ACWT_0525	COG1737	Transcriptional regulator
ACWT_0526	COG4821	SIS domain
ACWT_0534	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACWT_0537	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACWT_0540	COG1595	DNA-templated transcription, initiation
ACWT_0544	COG0745	RESPONSE REGULATOR receiver
ACWT_0544	COG3706	GGDEF domain
ACWT_0546	COG3706	GGDEF domain
ACWT_0546	COG0745	RESPONSE REGULATOR receiver
ACWT_0554	COG2409	Drug exporters of the RND superfamily
ACWT_0559	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACWT_0559	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACWT_0560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACWT_0561	COG2199	diguanylate cyclase activity
ACWT_0561	COG2200	EAL domain
ACWT_0561	COG2203	Gaf domain
ACWT_0562	COG3469	chitinase activity
ACWT_0564	COG0583	DNA-binding transcription factor activity
ACWT_0566	COG1388	LysM domain
ACWT_0567	COG3268	Saccharopine dehydrogenase
ACWT_0568	COG0275	rRNA processing
ACWT_0574	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACWT_0575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACWT_0576	COG2205	protein histidine kinase activity
ACWT_0577	COG0745	RESPONSE REGULATOR receiver
ACWT_0582	COG2201	protein-glutamate methylesterase activity
ACWT_0583	COG4251	negative regulation of phosphorylation
ACWT_0584	COG0784	Response regulator, receiver
ACWT_0585	COG0483	inositol monophosphate 1-phosphatase activity
ACWT_0588	COG2815	serine threonine protein kinase
ACWT_0588	COG0515	serine threonine protein kinase
ACWT_0591	COG0514	ATP-dependent DNA helicase (RecQ)
ACWT_0594	COG1937	Protein conserved in bacteria
ACWT_0600	COG0513	Belongs to the DEAD box helicase family
ACWT_0610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACWT_0611	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACWT_0613	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACWT_0619	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_0623	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_0624	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACWT_0625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_0626	COG0839	Belongs to the complex I subunit 6 family
ACWT_0627	COG0713	ATP synthesis coupled electron transport
ACWT_0628	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACWT_0629	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_0630	COG1007	ATP synthesis coupled electron transport
ACWT_0631	COG0501	Belongs to the peptidase M48B family
ACWT_0633	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_0639	COG1666	GTP binding
ACWT_0641	COG1280	lysine exporter protein (LysE YggA)
ACWT_0645	COG3300	MHYT domain
ACWT_0645	COG5001	Diguanylate cyclase
ACWT_0646	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACWT_0647	COG2030	dehydratase
ACWT_0651	COG0081	regulation of translation
ACWT_0654	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACWT_0655	COG0222	ribosome binding
ACWT_0656	COG0085	RNA polymerase activity
ACWT_0657	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACWT_0660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACWT_0661	COG0049	tRNA binding
ACWT_0662	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACWT_0663	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACWT_0664	COG0051	transcription antitermination factor activity, RNA binding
ACWT_0665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACWT_0666	COG0088	Forms part of the polypeptide exit tunnel
ACWT_0667	COG0089	rRNA binding
ACWT_0668	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACWT_0669	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACWT_0670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACWT_0671	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACWT_0672	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACWT_0673	COG0255	Belongs to the universal ribosomal protein uL29 family
ACWT_0674	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACWT_0675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACWT_0676	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACWT_0677	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACWT_0678	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACWT_0679	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACWT_0680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACWT_0681	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACWT_0682	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACWT_0683	COG1841	ribosomal large subunit assembly
ACWT_0684	COG0200	Binds to the 23S rRNA
ACWT_0686	COG0563	adenylate kinase activity
ACWT_0689	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACWT_0690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACWT_0691	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACWT_0692	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACWT_0693	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACWT_0695	COG0203	ribosomal protein L17
ACWT_0696	COG0101	tRNA pseudouridine synthase activity
ACWT_0698	COG2813	Specifically methylates the guanine in position
ACWT_0699	COG0488	(ABC) transporter
ACWT_0700	COG0352	thiamine-phosphate diphosphorylase activity
ACWT_0701	COG2022	thiamine diphosphate biosynthetic process
ACWT_0701	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACWT_0703	COG2022	thiamine diphosphate biosynthetic process
ACWT_0704	COG0352	thiamine-phosphate diphosphorylase activity
ACWT_0705	COG0351	phosphomethylpyrimidine kinase
ACWT_0706	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACWT_0712	COG2018	Roadblock/LC7 domain
ACWT_0716	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACWT_0717	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACWT_0718	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACWT_0721	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACWT_0725	COG0736	holo-[acyl-carrier-protein] synthase activity
ACWT_0727	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACWT_0729	COG0802	atpase or kinase
ACWT_0730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACWT_0733	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACWT_0735	COG1132	(ABC) transporter
ACWT_0737	COG0459	protein refolding
ACWT_0738	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACWT_0740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACWT_0741	COG4213	ABC transporter substrate-binding protein
ACWT_0743	COG4214	carbohydrate transport
ACWT_0750	COG2197	response regulator
ACWT_0753	COG0516	GMP reductase activity
ACWT_0755	COG1316	TRANSCRIPTIONal
ACWT_0756	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACWT_0756	COG0519	Catalyzes the synthesis of GMP from XMP
ACWT_0757	COG1051	belongs to the nudix hydrolase family
ACWT_0759	COG1183	phosphatidylcholine synthase activity
ACWT_0760	COG0688	phosphatidylethanolamine metabolic process
ACWT_0763	COG4585	Histidine kinase
ACWT_0764	COG2197	response regulator
ACWT_0765	COG4166	transmembrane transport
ACWT_0766	COG0601	transmembrane transport
ACWT_0768	COG0444	Belongs to the ABC transporter superfamily
ACWT_0769	COG4608	Belongs to the ABC transporter superfamily
ACWT_0770	COG1605	Chorismate mutase
ACWT_0771	COG0737	Belongs to the 5'-nucleotidase family
ACWT_0771	COG1525	nuclease
ACWT_0771	COG4085	toxin activity
ACWT_0773	COG0739	heme binding
ACWT_0775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACWT_0776	COG0045	succinate-CoA ligase (ADP-forming) activity
ACWT_0780	COG0138	bifunctional purine biosynthesis protein purh
ACWT_0783	COG0538	isocitrate dehydrogenase activity
ACWT_0785	COG1349	DNA-binding transcription factor activity
ACWT_0788	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACWT_0797	COG3206	protein involved in exopolysaccharide biosynthesis
ACWT_0797	COG0489	protein tyrosine kinase activity
ACWT_0798	COG0529	Catalyzes the synthesis of activated sulfate
ACWT_0802	COG1131	(ABC) transporter
ACWT_0804	COG0640	Transcriptional regulator
ACWT_0805	COG0604	alcohol dehydrogenase
ACWT_0806	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_0806	COG0604	alcohol dehydrogenase
ACWT_0806	COG3321	synthase
ACWT_0808	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACWT_0809	COG1024	Enoyl-CoA hydratase
ACWT_0809	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACWT_0816	COG0148	phosphopyruvate hydratase activity
ACWT_0819	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACWT_0825	COG0714	Associated with various cellular activities
ACWT_0831	COG0183	Belongs to the thiolase family
ACWT_0836	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACWT_0838	COG0456	acetyltransferase
ACWT_0839	COG1234	tRNA 3'-trailer cleavage
ACWT_0840	COG2326	polyphosphate kinase activity
ACWT_0845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACWT_0849	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACWT_0850	COG0501	Belongs to the peptidase M48B family
ACWT_0851	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACWT_0853	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACWT_0857	COG1331	Highly conserved protein containing a thioredoxin domain
ACWT_0859	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACWT_0868	COG5001	Diguanylate cyclase
ACWT_0872	COG1136	(ABC) transporter
ACWT_0872	COG0577	efflux transmembrane transporter activity
ACWT_0874	COG3903	Transcriptional regulator
ACWT_0874	COG3629	intracellular signal transduction
ACWT_0877	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACWT_0882	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACWT_0883	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACWT_0891	COG1132	(ABC) transporter
ACWT_0911	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACWT_0916	COG1609	Transcriptional regulator
ACWT_0919	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACWT_0923	COG1607	acyl-coa hydrolase
ACWT_0925	COG0438	transferase activity, transferring glycosyl groups
ACWT_0929	COG0778	Nitroreductase
ACWT_0929	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ACWT_0932	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACWT_0938	COG1012	belongs to the aldehyde dehydrogenase family
ACWT_0940	COG1515	deoxyribonuclease V activity
ACWT_0941	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACWT_0942	COG2835	tetraacyldisaccharide 4'-kinase activity
ACWT_0948	COG0745	RESPONSE REGULATOR receiver
ACWT_0949	COG5002	protein histidine kinase activity
ACWT_0952	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACWT_0954	COG0653	protein targeting
ACWT_0960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACWT_0961	COG2884	Cell division ATP-binding protein ftsE
ACWT_0962	COG2177	Part of the ABC transporter FtsEX involved in
ACWT_0963	COG0739	heme binding
ACWT_0963	COG0741	lytic transglycosylase activity
ACWT_0963	COG1196	nuclear chromosome segregation
ACWT_0964	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACWT_0993	COG1595	DNA-templated transcription, initiation
ACWT_0995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACWT_0996	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ACWT_0999	COG1678	Uncharacterized ACR, COG1678
ACWT_1000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACWT_1002	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_1006	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACWT_1010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACWT_1031	COG5001	Diguanylate cyclase
ACWT_1031	COG5002	protein histidine kinase activity
ACWT_1035	COG1793	dna ligase
ACWT_1035	COG3285	dna ligase
ACWT_1036	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACWT_1037	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACWT_1040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_1042	COG1335	isochorismatase
ACWT_1043	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACWT_1044	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACWT_1050	COG1234	tRNA 3'-trailer cleavage
ACWT_1051	COG0438	transferase activity, transferring glycosyl groups
ACWT_1052	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACWT_1053	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACWT_1054	COG2986	histidine ammonia-lyase
ACWT_1055	COG1228	amidohydrolase
ACWT_1056	COG0402	S-adenosylhomocysteine deaminase activity
ACWT_1057	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_1058	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACWT_1063	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACWT_1071	COG2372	response to copper ion
ACWT_1071	COG1276	copper resistance
ACWT_1073	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACWT_1081	COG3226	Transcriptional regulator
ACWT_1089	COG2197	response regulator
ACWT_1092	COG2124	cytochrome p450
ACWT_1094	COG2255	four-way junction helicase activity
ACWT_1097	COG5001	Diguanylate cyclase
ACWT_1097	COG5002	protein histidine kinase activity
ACWT_1115	COG0277	FAD linked oxidase domain protein
ACWT_1117	COG0745	RESPONSE REGULATOR receiver
ACWT_1121	COG0598	Magnesium transport protein CorA
ACWT_1133	COG1609	Transcriptional regulator
ACWT_1134	COG2706	6-phosphogluconolactonase activity
ACWT_1137	COG2115	Belongs to the xylose isomerase family
ACWT_1138	COG1070	Carbohydrate kinase
ACWT_1140	COG0366	Alpha amylase catalytic
ACWT_1141	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACWT_1147	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACWT_1162	COG2197	response regulator
ACWT_1165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACWT_1173	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACWT_1174	COG1492	cobalamin metabolic process
ACWT_1175	COG0501	Belongs to the peptidase M48B family
ACWT_1176	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_1179	COG1793	dna ligase
ACWT_1182	COG1797	cobyrinic acid a,c-diamide synthase activity
ACWT_1186	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACWT_1187	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACWT_1187	COG1648	precorrin-2 dehydrogenase activity
ACWT_1188	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACWT_1197	COG0668	transmembrane transport
ACWT_1202	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACWT_1205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACWT_1208	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACWT_1210	COG4552	Acetyltransferase involved in intracellular survival and related
ACWT_1214	COG0640	Transcriptional regulator
ACWT_1219	COG1595	DNA-templated transcription, initiation
ACWT_1220	COG0640	Transcriptional regulator
ACWT_1221	COG2814	Major facilitator Superfamily
ACWT_1226	COG1063	alcohol dehydrogenase
ACWT_1228	COG0693	protein deglycase activity
ACWT_1231	COG0494	nUDIX hydrolase
ACWT_1232	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACWT_1233	COG0740	serine-type endopeptidase activity
ACWT_1234	COG0740	serine-type endopeptidase activity
ACWT_1235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACWT_1237	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACWT_1240	COG0525	valine-tRNA ligase activity
ACWT_1241	COG0285	dihydrofolate synthase activity
ACWT_1244	COG0105	UTP biosynthetic process
ACWT_1245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACWT_1248	COG0596	Alpha beta hydrolase
ACWT_1253	COG1530	ribonuclease E activity
ACWT_1255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACWT_1256	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACWT_1257	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACWT_1258	COG2153	protein acetylation
ACWT_1259	COG0180	Tryptophanyl-tRNA synthetase
ACWT_1262	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACWT_1264	COG0406	alpha-ribazole phosphatase activity
ACWT_1266	COG1307	EDD domain protein, DegV family
ACWT_1268	COG2890	protein-(glutamine-N5) methyltransferase activity
ACWT_1269	COG1555	photosystem II stabilization
ACWT_1269	COG1596	polysaccharide export
ACWT_1270	COG2333	competence protein COMEC
ACWT_1270	COG0658	competence protein
ACWT_1273	COG0268	Binds directly to 16S ribosomal RNA
ACWT_1277	COG0481	GTPase activity
ACWT_1278	COG2261	transglycosylase associated protein
ACWT_1284	COG1420	regulation of RNA biosynthetic process
ACWT_1285	COG0484	heat shock protein binding
ACWT_1287	COG1695	Transcriptional regulator
ACWT_1290	COG0537	adenosine 5'-monophosphoramidase activity
ACWT_1293	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACWT_1296	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACWT_1299	COG1381	Involved in DNA repair and RecF pathway recombination
ACWT_1300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACWT_1307	COG1122	ATPase activity
ACWT_1309	COG2267	carboxylic ester hydrolase activity
ACWT_1314	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACWT_1315	COG1121	(ABC) transporter
ACWT_1316	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACWT_1320	COG0423	glycine-tRNA ligase activity
ACWT_1322	COG3608	succinylglutamate desuccinylase aspartoacylase
ACWT_1322	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACWT_1326	COG2018	Roadblock/LC7 domain
ACWT_1331	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACWT_1334	COG1131	(ABC) transporter
ACWT_1337	COG1295	ribonuclease BN
ACWT_1345	COG4115	mRNA cleavage
ACWT_1346	COG2161	toxin-antitoxin pair type II binding
ACWT_1351	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_1356	COG3469	chitinase activity
ACWT_1358	COG3250	beta-galactosidase activity
ACWT_1371	COG2746	aminoglycoside 3-N-acetyltransferase activity
ACWT_1373	COG0641	radical SAM
ACWT_1375	COG3903	Transcriptional regulator
ACWT_1375	COG3629	intracellular signal transduction
ACWT_1378	COG3629	intracellular signal transduction
ACWT_1378	COG3903	Transcriptional regulator
ACWT_1383	COG0018	arginyl-trna synthetase
ACWT_1384	COG0737	Belongs to the 5'-nucleotidase family
ACWT_1387	COG0515	serine threonine protein kinase
ACWT_1391	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACWT_1394	COG3973	AAA domain
ACWT_1399	COG1472	Belongs to the glycosyl hydrolase 3 family
ACWT_1402	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACWT_1403	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACWT_1409	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACWT_1410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACWT_1411	COG0432	Pfam Uncharacterised protein family UPF0047
ACWT_1417	COG3557	Belongs to the UPF0374 family
ACWT_1422	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACWT_1424	COG0328	RNA-DNA hybrid ribonuclease activity
ACWT_1424	COG0406	alpha-ribazole phosphatase activity
ACWT_1430	COG0730	response to heat
ACWT_1432	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACWT_1433	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACWT_1436	COG2226	methyltransferase
ACWT_1440	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ACWT_1441	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACWT_1442	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACWT_1442	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACWT_1443	COG0174	glutamine synthetase
ACWT_1444	COG3766	membrane
ACWT_1446	COG2378	regulation of single-species biofilm formation
ACWT_1449	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACWT_1450	COG1846	Transcriptional regulator
ACWT_1453	COG1051	belongs to the nudix hydrolase family
ACWT_1465	COG0438	transferase activity, transferring glycosyl groups
ACWT_1479	COG1674	ftsk spoiiie
ACWT_1487	COG1672	PFAM Archaeal ATPase
ACWT_1487	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACWT_1489	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACWT_1490	COG0017	Asparaginyl-tRNA synthetase
ACWT_1492	COG0321	lipoyl(octanoyl) transferase activity
ACWT_1495	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACWT_1496	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACWT_1498	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACWT_1499	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACWT_1500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACWT_1501	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACWT_1503	COG1994	Peptidase M50
ACWT_1504	COG0667	Aldo Keto reductase
ACWT_1509	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACWT_1512	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACWT_1513	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACWT_1514	COG1929	Belongs to the glycerate kinase type-1 family
ACWT_1518	COG0425	Belongs to the sulfur carrier protein TusA family
ACWT_1519	COG1104	cysteine desulfurase activity
ACWT_1520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACWT_1523	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACWT_1534	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACWT_1536	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACWT_1540	COG0501	Belongs to the peptidase M48B family
ACWT_1541	COG0438	transferase activity, transferring glycosyl groups
ACWT_1543	COG1132	(ABC) transporter
ACWT_1548	COG2197	response regulator
ACWT_1552	COG1940	carbohydrate kinase activity
ACWT_1558	COG0204	Acyl-transferase
ACWT_1564	COG0205	6-phosphofructokinase activity
ACWT_1574	COG0386	Belongs to the glutathione peroxidase family
ACWT_1576	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACWT_1580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACWT_1581	COG0515	serine threonine protein kinase
ACWT_1581	COG2815	serine threonine protein kinase
ACWT_1597	COG1309	transcriptional regulator
ACWT_1599	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACWT_1600	COG1053	succinate dehydrogenase
ACWT_1602	COG0583	DNA-binding transcription factor activity
ACWT_1625	COG0714	Associated with various cellular activities
ACWT_1626	COG0495	leucyl-tRNA aminoacylation
ACWT_1628	COG3442	glutamine amidotransferase
ACWT_1629	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACWT_1631	COG2001	Belongs to the MraZ family
ACWT_1632	COG0275	rRNA processing
ACWT_1634	COG0768	penicillin binding
ACWT_1635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACWT_1637	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACWT_1639	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACWT_1640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACWT_1642	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACWT_1644	COG1799	cell septum assembly
ACWT_1646	COG3599	regulation of cell shape
ACWT_1650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACWT_1654	COG0587	DNA-directed DNA polymerase activity
ACWT_1656	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACWT_1657	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACWT_1658	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACWT_1659	COG0131	Imidazoleglycerol-phosphate dehydratase
ACWT_1662	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACWT_1663	COG0107	imidazoleglycerol-phosphate synthase activity
ACWT_1667	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACWT_1669	COG1022	Amp-dependent synthetase and ligase
ACWT_1670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACWT_1673	COG0531	amino acid
ACWT_1675	COG1132	(ABC) transporter
ACWT_1676	COG1132	(ABC) transporter
ACWT_1677	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACWT_1680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACWT_1686	COG0159	tryptophan synthase activity
ACWT_1688	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACWT_1691	COG0067	glutamate synthase
ACWT_1691	COG0069	glutamate synthase activity
ACWT_1691	COG0070	glutamate synthase
ACWT_1703	COG0765	amino acid transport
ACWT_1709	COG2226	methyltransferase
ACWT_1710	COG0539	negative regulation of cytoplasmic translation
ACWT_1711	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ACWT_1711	COG0237	dephospho-CoA kinase activity
ACWT_1714	COG2329	Antibiotic biosynthesis monooxygenase
ACWT_1715	COG0861	Integral membrane protein TerC family
ACWT_1718	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACWT_1719	COG0740	serine-type endopeptidase activity
ACWT_1722	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACWT_1724	COG1162	GTPase activity
ACWT_1726	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACWT_1728	COG0322	excinuclease ABC activity
ACWT_1729	COG1660	Displays ATPase and GTPase activities
ACWT_1731	COG1481	regulation of sporulation
ACWT_1732	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACWT_1733	COG0126	phosphoglycerate kinase activity
ACWT_1734	COG0149	triose-phosphate isomerase activity
ACWT_1735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACWT_1739	COG0363	glucosamine-6-phosphate deaminase activity
ACWT_1742	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACWT_1743	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACWT_1744	COG0109	protoheme IX farnesyltransferase activity
ACWT_1752	COG0396	ATPase activity
ACWT_1753	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACWT_1754	COG0822	iron-sulfur transferase activity
ACWT_1761	COG0588	phosphoglycerate mutase activity
ACWT_1765	COG2321	neutral zinc metallopeptidase
ACWT_1768	COG1024	Enoyl-CoA hydratase
ACWT_1769	COG1132	(ABC) transporter
ACWT_1770	COG3663	DNA glycosylase
ACWT_1771	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_1774	COG1309	transcriptional regulator
ACWT_1776	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_1780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACWT_1783	COG0006	proline dipeptidase activity
ACWT_1790	COG0714	Associated with various cellular activities
ACWT_1793	COG2197	response regulator
ACWT_1794	COG4585	Histidine kinase
ACWT_1796	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACWT_1812	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACWT_1815	COG1365	unkown
ACWT_1816	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACWT_1819	COG1175	transmembrane transport
ACWT_1820	COG0395	ABC-type sugar transport system, permease component
ACWT_1822	COG1175	transmembrane transport
ACWT_1823	COG0395	ABC-type sugar transport system, permease component
ACWT_1824	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACWT_1824	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACWT_1826	COG3265	gluconokinase activity
ACWT_1831	COG4585	Histidine kinase
ACWT_1832	COG2197	response regulator
ACWT_1834	COG3706	GGDEF domain
ACWT_1834	COG0745	RESPONSE REGULATOR receiver
ACWT_1847	COG3304	Inner membrane component domain
ACWT_1853	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACWT_1854	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACWT_1856	COG1309	transcriptional regulator
ACWT_1859	COG1309	transcriptional regulator
ACWT_1860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACWT_1863	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_1865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACWT_1866	COG2815	serine threonine protein kinase
ACWT_1866	COG0515	serine threonine protein kinase
ACWT_1868	COG5634	Uncharacterized conserved protein (DUF2278)
ACWT_1873	COG1253	flavin adenine dinucleotide binding
ACWT_1874	COG0840	transmembrane signaling receptor activity
ACWT_1879	COG3706	GGDEF domain
ACWT_1887	COG1175	transmembrane transport
ACWT_1890	COG2205	protein histidine kinase activity
ACWT_1891	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACWT_1891	COG2205	protein histidine kinase activity
ACWT_1891	COG2198	Histidine kinase
ACWT_1891	COG0784	Response regulator, receiver
ACWT_1894	COG2205	protein histidine kinase activity
ACWT_1898	COG5002	protein histidine kinase activity
ACWT_1898	COG3850	Histidine kinase
ACWT_1900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACWT_1902	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACWT_1903	COG3387	PFAM Glycoside hydrolase 15-related
ACWT_1904	COG1525	nuclease
ACWT_1905	COG0667	Aldo Keto reductase
ACWT_1913	COG2192	nodulation
ACWT_1916	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACWT_1920	COG1129	ABC transporter
ACWT_1922	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACWT_1927	COG1316	TRANSCRIPTIONal
ACWT_1928	COG1216	Glycosyl transferase, family 2
ACWT_1928	COG0463	Glycosyl transferase, family 2
ACWT_1940	COG1378	Sugar-specific transcriptional regulator TrmB
ACWT_1945	COG0745	RESPONSE REGULATOR receiver
ACWT_1945	COG3706	GGDEF domain
ACWT_1948	COG2070	2-Nitropropane dioxygenase
ACWT_1954	COG0436	Aminotransferase
ACWT_1960	COG0667	Aldo Keto reductase
ACWT_1987	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACWT_1990	COG2199	diguanylate cyclase activity
ACWT_1990	COG2203	Gaf domain
ACWT_1993	COG1196	nuclear chromosome segregation
ACWT_1993	COG0741	lytic transglycosylase activity
ACWT_1993	COG0739	heme binding
ACWT_1996	COG0789	Transcriptional regulator
ACWT_1998	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACWT_2001	COG0243	molybdopterin cofactor binding
ACWT_2002	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACWT_2007	COG0438	transferase activity, transferring glycosyl groups
ACWT_2011	COG0439	Biotin carboxylase
ACWT_2017	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACWT_2018	COG1070	Carbohydrate kinase
ACWT_2019	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACWT_2025	COG2193	ferroxidase activity
ACWT_2027	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACWT_2032	COG0395	ABC-type sugar transport system, permease component
ACWT_2033	COG1486	melibiose metabolic process
ACWT_2039	COG3537	Alpha-1,2-mannosidase
ACWT_2053	COG1960	acyl-CoA dehydrogenase activity
ACWT_2054	COG1063	alcohol dehydrogenase
ACWT_2055	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACWT_2056	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACWT_2058	COG2814	Major facilitator Superfamily
ACWT_2065	COG2175	clavaminate synthase activity
ACWT_2073	COG2814	Major facilitator Superfamily
ACWT_2076	COG2197	response regulator
ACWT_2077	COG4585	Histidine kinase
ACWT_2083	COG0745	RESPONSE REGULATOR receiver
ACWT_2102	COG0464	growth
ACWT_2105	COG0714	Associated with various cellular activities
ACWT_2120	COG0642	Histidine kinase
ACWT_2123	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_2128	COG2201	protein-glutamate methylesterase activity
ACWT_2133	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_2140	COG0714	Associated with various cellular activities
ACWT_2148	COG2205	protein histidine kinase activity
ACWT_2149	COG0784	Response regulator, receiver
ACWT_2149	COG5002	protein histidine kinase activity
ACWT_2149	COG2198	Histidine kinase
ACWT_2151	COG2226	methyltransferase
ACWT_2152	COG2814	Major facilitator Superfamily
ACWT_2156	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACWT_2157	COG3537	Alpha-1,2-mannosidase
ACWT_2162	COG0789	Transcriptional regulator
ACWT_2163	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_2182	COG1609	Transcriptional regulator
ACWT_2185	COG0477	Major facilitator Superfamily
ACWT_2188	COG3347	Dehydrogenase
ACWT_2188	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_2189	COG1070	Carbohydrate kinase
ACWT_2190	COG0247	lactate metabolic process
ACWT_2191	COG1139	Iron-sulfur cluster binding protein
ACWT_2192	COG1556	Lactate utilization protein
ACWT_2194	COG0745	RESPONSE REGULATOR receiver
ACWT_2195	COG3852	Histidine kinase
ACWT_2198	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACWT_2199	COG0577	efflux transmembrane transporter activity
ACWT_2199	COG1136	(ABC) transporter
ACWT_2200	COG0577	efflux transmembrane transporter activity
ACWT_2200	COG1136	(ABC) transporter
ACWT_2204	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_2207	COG4948	Mandelate Racemase Muconate Lactonizing
ACWT_2210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACWT_2222	COG0596	Alpha beta hydrolase
ACWT_2223	COG1116	anion transmembrane transporter activity
ACWT_2224	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACWT_2225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACWT_2227	COG1414	Transcriptional regulator
ACWT_2231	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACWT_2232	COG3706	GGDEF domain
ACWT_2239	COG1414	Transcriptional regulator
ACWT_2240	COG3485	protocatechuate 3,4-dioxygenase
ACWT_2241	COG3485	protocatechuate 3,4-dioxygenase
ACWT_2243	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACWT_2249	COG2197	response regulator
ACWT_2255	COG0039	L-malate dehydrogenase activity
ACWT_2260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACWT_2281	COG1396	sequence-specific DNA binding
ACWT_2284	COG1072	(Pantothenic acid kinase))
ACWT_2291	COG1960	acyl-CoA dehydrogenase activity
ACWT_2293	COG1960	acyl-CoA dehydrogenase activity
ACWT_2294	COG1051	belongs to the nudix hydrolase family
ACWT_2296	COG0789	Transcriptional regulator
ACWT_2300	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACWT_2301	COG1472	Belongs to the glycosyl hydrolase 3 family
ACWT_2302	COG1609	Transcriptional regulator
ACWT_2304	COG1175	transmembrane transport
ACWT_2305	COG0395	ABC-type sugar transport system, permease component
ACWT_2306	COG1501	Belongs to the glycosyl hydrolase 31 family
ACWT_2310	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACWT_2312	COG1122	ATPase activity
ACWT_2315	COG0310	cobalt ion transport
ACWT_2316	COG5002	protein histidine kinase activity
ACWT_2319	COG0840	transmembrane signaling receptor activity
ACWT_2320	COG5002	protein histidine kinase activity
ACWT_2324	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACWT_2326	COG1129	ABC transporter
ACWT_2327	COG1879	ABC-type sugar transport system periplasmic component
ACWT_2331	COG0483	inositol monophosphate 1-phosphatase activity
ACWT_2332	COG2815	serine threonine protein kinase
ACWT_2332	COG0515	serine threonine protein kinase
ACWT_2336	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACWT_2337	COG1012	belongs to the aldehyde dehydrogenase family
ACWT_2338	COG3842	ATPase activity
ACWT_2339	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACWT_2340	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACWT_2341	COG1177	transmembrane transport
ACWT_2342	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACWT_2343	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACWT_2346	COG0745	RESPONSE REGULATOR receiver
ACWT_2348	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACWT_2351	COG1012	belongs to the aldehyde dehydrogenase family
ACWT_2352	COG2208	phosphoserine phosphatase activity
ACWT_2353	COG1472	Belongs to the glycosyl hydrolase 3 family
ACWT_2355	COG1175	transmembrane transport
ACWT_2357	COG1609	Transcriptional regulator
ACWT_2358	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_2359	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACWT_2362	COG0840	transmembrane signaling receptor activity
ACWT_2363	COG3191	aminopeptidase activity
ACWT_2367	COG0702	epimerase
ACWT_2368	COG1733	regulation of RNA biosynthetic process
ACWT_2371	COG5001	Diguanylate cyclase
ACWT_2371	COG3300	MHYT domain
ACWT_2373	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACWT_2373	COG1024	Enoyl-CoA hydratase
ACWT_2374	COG0183	Belongs to the thiolase family
ACWT_2375	COG1960	acyl-CoA dehydrogenase activity
ACWT_2379	COG1074	ATP-dependent DNA helicase activity
ACWT_2379	COG1074	ATP-dependent DNA helicase activity
ACWT_2386	COG2197	response regulator
ACWT_2388	COG4585	Histidine kinase
ACWT_2392	COG0601	transmembrane transport
ACWT_2398	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_2404	COG0656	L-ascorbic acid biosynthetic process
ACWT_2414	COG1126	abc transporter atp-binding protein
ACWT_2416	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACWT_2417	COG4521	taurine ABC transporter
ACWT_2420	COG0366	Alpha amylase catalytic
ACWT_2422	COG3237	CsbD-like
ACWT_2423	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_2424	COG2409	Drug exporters of the RND superfamily
ACWT_2428	COG1132	(ABC) transporter
ACWT_2431	COG0372	Belongs to the citrate synthase family
ACWT_2434	COG0596	Alpha beta hydrolase
ACWT_2434	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACWT_2442	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACWT_2443	COG2146	nitrite reductase [NAD(P)H] activity
ACWT_2444	COG2223	nitrite transmembrane transporter activity
ACWT_2449	COG1136	(ABC) transporter
ACWT_2450	COG1136	(ABC) transporter
ACWT_2451	COG0395	ABC-type sugar transport system, permease component
ACWT_2452	COG1175	transmembrane transport
ACWT_2453	COG1653	transport
ACWT_2454	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACWT_2456	COG4733	cellulase activity
ACWT_2456	COG5297	Belongs to the glycosyl hydrolase family 6
ACWT_2459	COG0009	L-threonylcarbamoyladenylate synthase
ACWT_2463	COG4213	ABC transporter substrate-binding protein
ACWT_2464	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACWT_2466	COG2409	Drug exporters of the RND superfamily
ACWT_2467	COG0247	lactate metabolic process
ACWT_2468	COG0277	FAD linked oxidase domain protein
ACWT_2469	COG0277	FAD linked oxidase domain protein
ACWT_2471	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACWT_2471	COG0574	Belongs to the PEP-utilizing enzyme family
ACWT_2474	COG0514	ATP-dependent DNA helicase (RecQ)
ACWT_2476	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACWT_2480	COG0297	glycogen (starch) synthase activity
ACWT_2484	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACWT_2490	COG0326	Molecular chaperone. Has ATPase activity
ACWT_2496	COG1309	transcriptional regulator
ACWT_2499	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACWT_2508	COG0477	Major facilitator Superfamily
ACWT_2509	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACWT_2510	COG0840	transmembrane signaling receptor activity
ACWT_2512	COG4988	ABC transporter
ACWT_2513	COG1294	oxidase, subunit
ACWT_2514	COG1271	oxidase subunit
ACWT_2516	COG0501	Belongs to the peptidase M48B family
ACWT_2517	COG3883	PFAM NLP P60 protein
ACWT_2517	COG0791	NLP P60 protein
ACWT_2518	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACWT_2524	COG0159	tryptophan synthase activity
ACWT_2525	COG0133	tryptophan synthase activity
ACWT_2527	COG0745	RESPONSE REGULATOR receiver
ACWT_2528	COG2205	protein histidine kinase activity
ACWT_2534	COG5297	Belongs to the glycosyl hydrolase family 6
ACWT_2537	COG3345	alpha-galactosidase
ACWT_2538	COG3507	Belongs to the glycosyl hydrolase 43 family
ACWT_2541	COG3693	PFAM glycoside hydrolase, family 10
ACWT_2543	COG3693	PFAM glycoside hydrolase, family 10
ACWT_2552	COG1620	l-lactate permease
ACWT_2553	COG1228	amidohydrolase
ACWT_2555	COG3328	transposase activity
ACWT_2567	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACWT_2568	COG0166	Belongs to the GPI family
ACWT_2572	COG0515	serine threonine protein kinase
ACWT_2579	COG1309	transcriptional regulator
ACWT_2581	COG2076	Multidrug Resistance protein
ACWT_2587	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACWT_2588	COG0745	RESPONSE REGULATOR receiver
ACWT_2592	COG0601	transmembrane transport
ACWT_2593	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACWT_2594	COG0444	Belongs to the ABC transporter superfamily
ACWT_2595	COG4608	Belongs to the ABC transporter superfamily
ACWT_2600	COG1940	carbohydrate kinase activity
ACWT_2605	COG1609	Transcriptional regulator
ACWT_2607	COG0406	alpha-ribazole phosphatase activity
ACWT_2614	COG0745	RESPONSE REGULATOR receiver
ACWT_2615	COG2205	protein histidine kinase activity
ACWT_2617	COG0577	efflux transmembrane transporter activity
ACWT_2617	COG1136	(ABC) transporter
ACWT_2618	COG1136	(ABC) transporter
ACWT_2618	COG0577	efflux transmembrane transporter activity
ACWT_2622	COG0861	Integral membrane protein TerC family
ACWT_2623	COG3384	dioxygenase
ACWT_2626	COG3718	enzyme involved in inositol metabolism
ACWT_2627	COG3962	Belongs to the TPP enzyme family
ACWT_2628	COG1082	Xylose isomerase domain protein TIM barrel
ACWT_2630	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACWT_2632	COG0673	inositol 2-dehydrogenase activity
ACWT_2635	COG3396	Phenylacetate-CoA oxygenase
ACWT_2636	COG3460	Phenylacetate-CoA oxygenase
ACWT_2637	COG3396	Phenylacetate-CoA oxygenase
ACWT_2638	COG2151	metal-sulfur cluster biosynthetic enzyme
ACWT_2639	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACWT_2640	COG2226	methyltransferase
ACWT_2643	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACWT_2644	COG1132	(ABC) transporter
ACWT_2645	COG1408	metallophosphoesterase
ACWT_2651	COG0515	serine threonine protein kinase
ACWT_2652	COG0531	amino acid
ACWT_2655	COG2124	cytochrome p450
ACWT_2657	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACWT_2661	COG3300	MHYT domain
ACWT_2661	COG5001	Diguanylate cyclase
ACWT_2663	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACWT_2664	COG4279	zinc finger
ACWT_2670	COG3022	response to hydroperoxide
ACWT_2672	COG1476	TRANSCRIPTIONal
ACWT_2679	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACWT_2683	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ACWT_2685	COG0494	nUDIX hydrolase
ACWT_2693	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACWT_2698	COG0667	Aldo Keto reductase
ACWT_2712	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACWT_2714	COG1324	tolerance protein
ACWT_2716	COG3540	Alkaline phosphatase
ACWT_2720	COG3706	GGDEF domain
ACWT_2723	COG3300	MHYT domain
ACWT_2723	COG5001	Diguanylate cyclase
ACWT_2724	COG3511	phospholipase C
ACWT_2730	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_2731	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACWT_2732	COG1960	acyl-CoA dehydrogenase activity
ACWT_2740	COG1509	lysine 2,3-aminomutase activity
ACWT_2741	COG0604	alcohol dehydrogenase
ACWT_2742	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ACWT_2743	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACWT_2744	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACWT_2745	COG1607	acyl-coa hydrolase
ACWT_2748	COG0463	Glycosyl transferase, family 2
ACWT_2757	COG0640	Transcriptional regulator
ACWT_2760	COG0778	Nitroreductase
ACWT_2763	COG0577	efflux transmembrane transporter activity
ACWT_2763	COG1136	(ABC) transporter
ACWT_2766	COG4214	carbohydrate transport
ACWT_2767	COG4213	ABC transporter substrate-binding protein
ACWT_2769	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACWT_2770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACWT_2771	COG2080	2 iron, 2 sulfur cluster binding
ACWT_2777	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_2783	COG0693	protein deglycase activity
ACWT_2788	COG0488	(ABC) transporter
ACWT_2790	COG0583	DNA-binding transcription factor activity
ACWT_2791	COG0183	Belongs to the thiolase family
ACWT_2793	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACWT_2794	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_2796	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACWT_2797	COG0410	ABC transporter
ACWT_2798	COG0411	ABC transporter
ACWT_2800	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_2801	COG0596	Alpha beta hydrolase
ACWT_2809	COG1984	allophanate hydrolase subunit 2
ACWT_2810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACWT_2816	COG2201	protein-glutamate methylesterase activity
ACWT_2819	COG2201	protein-glutamate methylesterase activity
ACWT_2821	COG0701	Predicted permease
ACWT_2824	COG1690	Belongs to the RtcB family
ACWT_2827	COG3300	MHYT domain
ACWT_2827	COG5001	Diguanylate cyclase
ACWT_2833	COG0436	Aminotransferase
ACWT_2836	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACWT_2843	COG0242	peptide deformylase activity
ACWT_2845	COG3866	Pectate lyase
ACWT_2846	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_2847	COG0783	Belongs to the Dps family
ACWT_2852	COG0028	Belongs to the TPP enzyme family
ACWT_2857	COG0714	Associated with various cellular activities
ACWT_2865	COG0531	amino acid
ACWT_2870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACWT_2872	COG3973	AAA domain
ACWT_2874	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACWT_2878	COG2801	Transposase and inactivated derivatives
ACWT_2878	COG3415	Transposase
ACWT_2879	COG3293	Transposase
ACWT_2883	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_2892	COG2192	nodulation
ACWT_2894	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACWT_2896	COG0438	transferase activity, transferring glycosyl groups
ACWT_2897	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACWT_2897	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACWT_2899	COG0859	PFAM glycosyl transferase family 9
ACWT_2926	COG1742	UPF0060 membrane protein
ACWT_2928	COG0456	acetyltransferase
ACWT_2933	COG0494	nUDIX hydrolase
ACWT_2934	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACWT_2934	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACWT_2941	COG0024	Methionine aminopeptidase
ACWT_2946	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_2951	COG0583	DNA-binding transcription factor activity
ACWT_2964	COG2815	serine threonine protein kinase
ACWT_2964	COG0515	serine threonine protein kinase
ACWT_2973	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACWT_2977	COG1522	sequence-specific DNA binding
ACWT_2992	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_2995	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACWT_2996	COG0022	dehydrogenase e1 component
ACWT_2997	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACWT_2998	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACWT_3004	COG0673	inositol 2-dehydrogenase activity
ACWT_3005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACWT_3006	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACWT_3008	COG2226	methyltransferase
ACWT_3011	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACWT_3014	COG0456	acetyltransferase
ACWT_3015	COG0277	FAD linked oxidase domain protein
ACWT_3015	COG0247	lactate metabolic process
ACWT_3017	COG3629	intracellular signal transduction
ACWT_3017	COG3903	Transcriptional regulator
ACWT_3020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACWT_3021	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACWT_3028	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACWT_3031	COG4677	pectinesterase activity
ACWT_3055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACWT_3057	COG4585	Histidine kinase
ACWT_3058	COG2197	response regulator
ACWT_3067	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACWT_3068	COG1737	Transcriptional regulator
ACWT_3069	COG3876	Protein conserved in bacteria
ACWT_3070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACWT_3072	COG1175	transmembrane transport
ACWT_3079	COG2205	protein histidine kinase activity
ACWT_3080	COG0745	RESPONSE REGULATOR receiver
ACWT_3085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACWT_3086	COG1131	(ABC) transporter
ACWT_3093	COG2304	oxidoreductase activity
ACWT_3095	COG2197	response regulator
ACWT_3099	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACWT_3100	COG0438	transferase activity, transferring glycosyl groups
ACWT_3111	COG2199	diguanylate cyclase activity
ACWT_3111	COG2200	EAL domain
ACWT_3111	COG3287	FIST C domain
ACWT_3129	COG0431	NADPH-dependent FMN reductase
ACWT_3130	COG3795	YCII-related domain
ACWT_3131	COG4941	Belongs to the sigma-70 factor family
ACWT_3137	COG0387	Pfam Sodium calcium exchanger
ACWT_3140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACWT_3140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACWT_3144	COG0745	RESPONSE REGULATOR receiver
ACWT_3145	COG2205	protein histidine kinase activity
ACWT_3146	COG0667	Aldo Keto reductase
ACWT_3154	COG1131	(ABC) transporter
ACWT_3158	COG1968	undecaprenyl-diphosphatase activity
ACWT_3165	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ACWT_3166	COG0586	Pfam SNARE associated Golgi protein
ACWT_3188	COG2755	lipolytic protein G-D-S-L family
ACWT_3199	COG2201	protein-glutamate methylesterase activity
ACWT_3200	COG2205	protein histidine kinase activity
ACWT_3201	COG0745	RESPONSE REGULATOR receiver
ACWT_3211	COG4585	Histidine kinase
ACWT_3214	COG2814	Major facilitator Superfamily
ACWT_3234	COG5002	protein histidine kinase activity
ACWT_3246	COG5002	protein histidine kinase activity
ACWT_3246	COG5001	Diguanylate cyclase
ACWT_3246	COG3447	MASE1 domain protein
ACWT_3248	COG0784	Response regulator, receiver
ACWT_3248	COG2205	protein histidine kinase activity
ACWT_3248	COG5002	protein histidine kinase activity
ACWT_3249	COG3300	MHYT domain
ACWT_3249	COG5001	Diguanylate cyclase
ACWT_3255	COG3511	phospholipase C
ACWT_3261	COG1606	tRNA processing
ACWT_3267	COG0784	Response regulator, receiver
ACWT_3267	COG4191	Histidine kinase
ACWT_3269	COG3706	GGDEF domain
ACWT_3269	COG0745	RESPONSE REGULATOR receiver
ACWT_3280	COG4941	Belongs to the sigma-70 factor family
ACWT_3281	COG3706	GGDEF domain
ACWT_3285	COG3409	Peptidoglycan-binding domain 1 protein
ACWT_3287	COG5001	Diguanylate cyclase
ACWT_3289	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACWT_3295	COG0443	Heat shock 70 kDa protein
ACWT_3299	COG5002	protein histidine kinase activity
ACWT_3300	COG2203	Gaf domain
ACWT_3300	COG2199	diguanylate cyclase activity
ACWT_3302	COG0745	RESPONSE REGULATOR receiver
ACWT_3313	COG3706	GGDEF domain
ACWT_3314	COG3706	GGDEF domain
ACWT_3314	COG0745	RESPONSE REGULATOR receiver
ACWT_3319	COG1215	transferase activity, transferring glycosyl groups
ACWT_3320	COG5002	protein histidine kinase activity
ACWT_3324	COG0840	transmembrane signaling receptor activity
ACWT_3329	COG1295	ribonuclease BN
ACWT_3330	COG1309	transcriptional regulator
ACWT_3337	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_3339	COG2205	protein histidine kinase activity
ACWT_3340	COG5002	protein histidine kinase activity
ACWT_3345	COG0515	serine threonine protein kinase
ACWT_3345	COG2815	serine threonine protein kinase
ACWT_3374	COG1090	epimerase
ACWT_3391	COG5001	Diguanylate cyclase
ACWT_3392	COG3903	Transcriptional regulator
ACWT_3392	COG3629	intracellular signal transduction
ACWT_3395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACWT_3396	COG4251	negative regulation of phosphorylation
ACWT_3404	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ACWT_3405	COG5002	protein histidine kinase activity
ACWT_3408	COG1982	Orn Lys Arg decarboxylase major
ACWT_3409	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACWT_3418	COG2801	Transposase and inactivated derivatives
ACWT_3432	COG0515	serine threonine protein kinase
ACWT_3440	COG2197	response regulator
ACWT_3450	COG1136	(ABC) transporter
ACWT_3450	COG0577	efflux transmembrane transporter activity
ACWT_3451	COG4585	Histidine kinase
ACWT_3453	COG0745	RESPONSE REGULATOR receiver
ACWT_3453	COG3706	GGDEF domain
ACWT_3455	COG0492	ferredoxin-NADP+ reductase activity
ACWT_3467	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACWT_3467	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACWT_3475	COG1335	isochorismatase
ACWT_3477	COG2267	carboxylic ester hydrolase activity
ACWT_3479	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACWT_3486	COG5001	Diguanylate cyclase
ACWT_3486	COG3300	MHYT domain
ACWT_3490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACWT_3495	COG2815	serine threonine protein kinase
ACWT_3495	COG0515	serine threonine protein kinase
ACWT_3498	COG1609	Transcriptional regulator
ACWT_3505	COG1309	transcriptional regulator
ACWT_3511	COG3209	COG3209 Rhs family protein
ACWT_3519	COG0840	transmembrane signaling receptor activity
ACWT_3524	COG4124	Belongs to the glycosyl hydrolase 26 family
ACWT_3526	COG1940	carbohydrate kinase activity
ACWT_3529	COG1846	Transcriptional regulator
ACWT_3530	COG3387	PFAM Glycoside hydrolase 15-related
ACWT_3532	COG3940	Belongs to the glycosyl hydrolase 43 family
ACWT_3538	COG1131	(ABC) transporter
ACWT_3539	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACWT_3542	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACWT_3545	COG0561	phosphatase activity
ACWT_3547	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACWT_3548	COG1940	carbohydrate kinase activity
ACWT_3550	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_3551	COG1082	Xylose isomerase domain protein TIM barrel
ACWT_3552	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACWT_3553	COG1088	dTDP-glucose 4,6-dehydratase activity
ACWT_3554	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ACWT_3558	COG1175	transmembrane transport
ACWT_3562	COG0702	epimerase
ACWT_3563	COG1733	regulation of RNA biosynthetic process
ACWT_3571	COG4251	negative regulation of phosphorylation
ACWT_3579	COG3850	Histidine kinase
ACWT_3579	COG4999	Histidine kinase
ACWT_3579	COG3437	response regulator, receiver
ACWT_3579	COG2205	protein histidine kinase activity
ACWT_3581	COG0840	transmembrane signaling receptor activity
ACWT_3583	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACWT_3588	COG0640	Transcriptional regulator
ACWT_3603	COG1918	ferrous iron import across plasma membrane
ACWT_3603	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACWT_3604	COG1278	Cold shock
ACWT_3607	COG3979	chitinase
ACWT_3608	COG3469	chitinase activity
ACWT_3613	COG0745	RESPONSE REGULATOR receiver
ACWT_3614	COG2205	protein histidine kinase activity
ACWT_3615	COG2409	Drug exporters of the RND superfamily
ACWT_3632	COG1597	lipid kinase activity
ACWT_3645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACWT_3662	COG5001	Diguanylate cyclase
ACWT_3662	COG3300	MHYT domain
ACWT_3665	COG2261	transglycosylase associated protein
ACWT_3675	COG4172	Belongs to the ABC transporter superfamily
ACWT_3680	COG1902	pentaerythritol trinitrate reductase activity
ACWT_3689	COG4585	Histidine kinase
ACWT_3693	COG1136	(ABC) transporter
ACWT_3717	COG0519	Catalyzes the synthesis of GMP from XMP
ACWT_3718	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACWT_3719	COG0596	Alpha beta hydrolase
ACWT_3721	COG2197	response regulator
ACWT_3722	COG4585	Histidine kinase
ACWT_3726	COG3706	GGDEF domain
ACWT_3730	COG3706	GGDEF domain
ACWT_3730	COG0745	RESPONSE REGULATOR receiver
ACWT_3740	COG1609	Transcriptional regulator
ACWT_3743	COG1175	transmembrane transport
ACWT_3744	COG0395	ABC-type sugar transport system, permease component
ACWT_3748	COG1132	(ABC) transporter
ACWT_3753	COG2259	Doxx family
ACWT_3764	COG0583	DNA-binding transcription factor activity
ACWT_3768	COG2226	methyltransferase
ACWT_3772	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_3781	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACWT_3782	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACWT_3783	COG1414	Transcriptional regulator
ACWT_3784	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACWT_3785	COG4941	Belongs to the sigma-70 factor family
ACWT_3786	COG3795	YCII-related domain
ACWT_3788	COG2072	flavoprotein involved in K transport
ACWT_3794	COG5001	Diguanylate cyclase
ACWT_3813	COG0745	RESPONSE REGULATOR receiver
ACWT_3813	COG3706	GGDEF domain
ACWT_3818	COG0142	geranyltranstransferase activity
ACWT_3819	COG0477	Major facilitator Superfamily
ACWT_3821	COG0531	amino acid
ACWT_3824	COG0583	DNA-binding transcription factor activity
ACWT_3825	COG0483	inositol monophosphate 1-phosphatase activity
ACWT_3839	COG2124	cytochrome p450
ACWT_3841	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACWT_3844	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_3854	COG0628	permease
ACWT_3860	COG2909	trisaccharide binding
ACWT_3862	COG2909	trisaccharide binding
ACWT_3865	COG0531	amino acid
ACWT_3866	COG2235	arginine
ACWT_3867	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACWT_3868	COG0549	Belongs to the carbamate kinase family
ACWT_3875	COG0477	Major facilitator Superfamily
ACWT_3880	COG1597	lipid kinase activity
ACWT_3891	COG0531	amino acid
ACWT_3894	COG0477	Major facilitator Superfamily
ACWT_3899	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACWT_3900	COG0406	alpha-ribazole phosphatase activity
ACWT_3905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACWT_3909	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACWT_3917	COG0640	Transcriptional regulator
ACWT_3919	COG0745	RESPONSE REGULATOR receiver
ACWT_3920	COG5002	protein histidine kinase activity
ACWT_3926	COG0789	Transcriptional regulator
ACWT_3941	COG1672	PFAM Archaeal ATPase
ACWT_3941	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACWT_3943	COG3173	Aminoglycoside phosphotransferase
ACWT_3944	COG1309	transcriptional regulator
ACWT_3966	COG2208	phosphoserine phosphatase activity
ACWT_3966	COG2770	Histidine kinase
ACWT_3970	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACWT_3988	COG2197	response regulator
ACWT_3991	COG4104	PAAR repeat-containing protein
ACWT_3993	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACWT_3999	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_4001	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_4005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACWT_4006	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACWT_4007	COG2197	response regulator
ACWT_4012	COG1595	DNA-templated transcription, initiation
ACWT_4016	COG0463	Glycosyl transferase, family 2
ACWT_4020	COG0076	glutamate decarboxylase activity
ACWT_4030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACWT_4032	COG2020	methyltransferase activity
ACWT_4033	COG1556	Lactate utilization protein
ACWT_4034	COG1139	Iron-sulfur cluster binding protein
ACWT_4035	COG0247	lactate metabolic process
ACWT_4036	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACWT_4038	COG1129	ABC transporter
ACWT_4039	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACWT_4042	COG2186	Transcriptional regulator
ACWT_4045	COG2186	Transcriptional regulator
ACWT_4046	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_4048	COG3706	GGDEF domain
ACWT_4048	COG0745	RESPONSE REGULATOR receiver
ACWT_4056	COG2186	Transcriptional regulator
ACWT_4058	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_4060	COG2186	Transcriptional regulator
ACWT_4061	COG2267	carboxylic ester hydrolase activity
ACWT_4062	COG5002	protein histidine kinase activity
ACWT_4063	COG0745	RESPONSE REGULATOR receiver
ACWT_4066	COG1136	(ABC) transporter
ACWT_4066	COG0577	efflux transmembrane transporter activity
ACWT_4067	COG1136	(ABC) transporter
ACWT_4067	COG0577	efflux transmembrane transporter activity
ACWT_4072	COG0640	Transcriptional regulator
ACWT_4082	COG2226	methyltransferase
ACWT_4085	COG1595	DNA-templated transcription, initiation
ACWT_4090	COG0840	transmembrane signaling receptor activity
ACWT_4094	COG3795	YCII-related domain
ACWT_4095	COG4941	Belongs to the sigma-70 factor family
ACWT_4107	COG1309	transcriptional regulator
ACWT_4110	COG2197	response regulator
ACWT_4111	COG4585	Histidine kinase
ACWT_4114	COG2267	carboxylic ester hydrolase activity
ACWT_4116	COG3795	YCII-related domain
ACWT_4117	COG4941	Belongs to the sigma-70 factor family
ACWT_4121	COG0681	Belongs to the peptidase S26 family
ACWT_4122	COG0583	DNA-binding transcription factor activity
ACWT_4125	COG1942	4-Oxalocrotonate Tautomerase
ACWT_4136	COG4221	oxidoreductase activity
ACWT_4151	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_4154	COG0861	Integral membrane protein TerC family
ACWT_4161	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACWT_4167	COG1131	(ABC) transporter
ACWT_4168	COG0842	Transport permease protein
ACWT_4169	COG4585	Histidine kinase
ACWT_4170	COG2197	response regulator
ACWT_4171	COG1191	sigma factor activity
ACWT_4173	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACWT_4174	COG0488	(ABC) transporter
ACWT_4175	COG4974	Belongs to the 'phage' integrase family
ACWT_4176	COG1968	undecaprenyl-diphosphatase activity
ACWT_4181	COG4974	Belongs to the 'phage' integrase family
ACWT_4182	COG1506	peptidase
ACWT_4182	COG0823	Involved in the tonB-independent uptake of proteins
ACWT_4184	COG2226	methyltransferase
ACWT_4195	COG1522	sequence-specific DNA binding
ACWT_4198	COG0667	Aldo Keto reductase
ACWT_4206	COG2197	response regulator
ACWT_4210	COG2270	Major facilitator Superfamily
ACWT_4216	COG2076	Multidrug Resistance protein
ACWT_4220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ACWT_4222	COG4702	Belongs to the UPF0303 family
ACWT_4227	COG1846	Transcriptional regulator
ACWT_4228	COG1764	response to oxidative stress
ACWT_4241	COG0019	diaminopimelate decarboxylase activity
ACWT_4251	COG0667	Aldo Keto reductase
ACWT_4256	COG0714	Associated with various cellular activities
ACWT_4262	COG4221	oxidoreductase activity
ACWT_4277	COG0242	peptide deformylase activity
ACWT_4280	COG1595	DNA-templated transcription, initiation
ACWT_4281	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACWT_4283	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACWT_4283	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACWT_4284	COG0667	Aldo Keto reductase
ACWT_4287	COG2226	methyltransferase
ACWT_4299	COG0672	)-iron permease
ACWT_4300	COG2822	iron ion transport
ACWT_4301	COG2837	iron assimilation
ACWT_4320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACWT_4327	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACWT_4334	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACWT_4339	COG1278	Cold shock
ACWT_4340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACWT_4342	COG2197	response regulator
ACWT_4357	COG0346	lactoylglutathione lyase activity
ACWT_4359	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACWT_4360	COG0840	transmembrane signaling receptor activity
ACWT_4370	COG1819	glycosyl
ACWT_4374	COG1024	Enoyl-CoA hydratase
ACWT_4377	COG1024	Enoyl-CoA hydratase
ACWT_4378	COG1902	pentaerythritol trinitrate reductase activity
ACWT_4378	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACWT_4380	COG2814	Major facilitator Superfamily
ACWT_4387	COG1760	l-serine dehydratase
ACWT_4388	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACWT_4395	COG1733	regulation of RNA biosynthetic process
ACWT_4397	COG1309	transcriptional regulator
ACWT_4402	COG1132	(ABC) transporter
ACWT_4403	COG1132	(ABC) transporter
ACWT_4406	COG0515	serine threonine protein kinase
ACWT_4409	COG1215	transferase activity, transferring glycosyl groups
ACWT_4417	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_4420	COG5001	Diguanylate cyclase
ACWT_4433	COG2197	response regulator
ACWT_4438	COG1733	regulation of RNA biosynthetic process
ACWT_4439	COG2910	NAD(P)H-binding
ACWT_4445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_4459	COG1881	PFAM PEBP family protein
ACWT_4467	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACWT_4470	COG0640	Transcriptional regulator
ACWT_4474	COG5001	Diguanylate cyclase
ACWT_4474	COG3447	MASE1 domain protein
ACWT_4474	COG5002	protein histidine kinase activity
ACWT_4478	COG0300	oxidoreductase activity
ACWT_4479	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACWT_4479	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACWT_4484	COG5002	protein histidine kinase activity
ACWT_4485	COG2202	Pas domain
ACWT_4485	COG2205	protein histidine kinase activity
ACWT_4487	COG1175	transmembrane transport
ACWT_4489	COG0789	Transcriptional regulator
ACWT_4496	COG0745	RESPONSE REGULATOR receiver
ACWT_4496	COG3706	GGDEF domain
ACWT_4506	COG3467	pyridoxamine 5'-phosphate
ACWT_4509	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_4512	COG0492	ferredoxin-NADP+ reductase activity
ACWT_4513	COG0640	Transcriptional regulator
ACWT_4515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACWT_4526	COG2721	sulfolactate sulfo-lyase activity
ACWT_4530	COG1609	Transcriptional regulator
ACWT_4533	COG0784	Response regulator, receiver
ACWT_4535	COG1278	Cold shock
ACWT_4537	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACWT_4540	COG1260	myo-inositol-1-phosphate synthase
ACWT_4542	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACWT_4544	COG0583	DNA-binding transcription factor activity
ACWT_4555	COG5001	Diguanylate cyclase
ACWT_4561	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_4562	COG2890	protein-(glutamine-N5) methyltransferase activity
ACWT_4563	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_4572	COG5002	protein histidine kinase activity
ACWT_4573	COG0745	RESPONSE REGULATOR receiver
ACWT_4579	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACWT_4594	COG5001	Diguanylate cyclase
ACWT_4594	COG3300	MHYT domain
ACWT_4595	COG1404	Belongs to the peptidase S8 family
ACWT_4596	COG4251	negative regulation of phosphorylation
ACWT_4597	COG1982	Orn Lys Arg decarboxylase major
ACWT_4601	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACWT_4603	COG0778	Nitroreductase
ACWT_4607	COG2267	carboxylic ester hydrolase activity
ACWT_4618	COG2814	Major facilitator Superfamily
ACWT_4619	COG2011	ABC-type metal ion transport system permease component
ACWT_4620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACWT_4628	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_4630	COG1695	Transcriptional regulator
ACWT_4635	COG1064	alcohol dehydrogenase
ACWT_4644	COG1476	TRANSCRIPTIONal
ACWT_4646	COG3629	intracellular signal transduction
ACWT_4646	COG3903	Transcriptional regulator
ACWT_4654	COG2357	RelA SpoT domain protein
ACWT_4660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_4664	COG0438	transferase activity, transferring glycosyl groups
ACWT_4669	COG3437	response regulator, receiver
ACWT_4669	COG3850	Histidine kinase
ACWT_4669	COG4999	Histidine kinase
ACWT_4669	COG2205	protein histidine kinase activity
ACWT_4670	COG4251	negative regulation of phosphorylation
ACWT_4675	COG0745	RESPONSE REGULATOR receiver
ACWT_4678	COG0784	Response regulator, receiver
ACWT_4678	COG2205	protein histidine kinase activity
ACWT_4678	COG5002	protein histidine kinase activity
ACWT_4682	COG5001	Diguanylate cyclase
ACWT_4689	COG0300	oxidoreductase activity
ACWT_4691	COG0667	Aldo Keto reductase
ACWT_4703	COG1691	(AIR) carboxylase
ACWT_4705	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ACWT_4713	COG0477	Major facilitator Superfamily
ACWT_4717	COG2226	methyltransferase
ACWT_4721	COG5002	protein histidine kinase activity
ACWT_4743	COG4762	Protein conserved in bacteria
ACWT_4760	COG0477	Major facilitator Superfamily
ACWT_4773	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACWT_4777	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACWT_4780	COG3239	Fatty acid desaturase
ACWT_4783	COG1376	ErfK ybiS ycfS ynhG family protein
ACWT_4786	COG1595	DNA-templated transcription, initiation
ACWT_4805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACWT_4811	COG3693	PFAM glycoside hydrolase, family 10
ACWT_4815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACWT_4815	COG2755	lipolytic protein G-D-S-L family
ACWT_4818	COG0840	transmembrane signaling receptor activity
ACWT_4825	COG0583	DNA-binding transcription factor activity
ACWT_4830	COG1309	transcriptional regulator
ACWT_4846	COG0393	Putative heavy-metal-binding
ACWT_4847	COG0393	Putative heavy-metal-binding
ACWT_4869	COG2801	Transposase and inactivated derivatives
ACWT_4869	COG3415	Transposase
ACWT_4880	COG1131	(ABC) transporter
ACWT_4881	COG1131	(ABC) transporter
ACWT_4893	COG0515	serine threonine protein kinase
ACWT_4894	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACWT_4895	COG0697	spore germination
ACWT_4896	COG1686	Belongs to the peptidase S11 family
ACWT_4902	COG1335	isochorismatase
ACWT_4908	COG0714	Associated with various cellular activities
ACWT_4914	COG3706	GGDEF domain
ACWT_4914	COG0745	RESPONSE REGULATOR receiver
ACWT_4916	COG0714	Associated with various cellular activities
ACWT_4917	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACWT_4927	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACWT_4933	COG0745	RESPONSE REGULATOR receiver
ACWT_4934	COG2205	protein histidine kinase activity
ACWT_4938	COG0367	asparagine synthase
ACWT_4939	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACWT_4943	COG1716	ATPase activity
ACWT_4944	COG0509	glycine decarboxylation via glycine cleavage system
ACWT_4953	COG0640	Transcriptional regulator
ACWT_4954	COG4867	von Willebrand factor, type A
ACWT_4955	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ACWT_4956	COG0384	phenazine biosynthesis protein PhzF
ACWT_4957	COG3447	MASE1 domain protein
ACWT_4957	COG5001	Diguanylate cyclase
ACWT_4957	COG5002	protein histidine kinase activity
ACWT_4958	COG0488	(ABC) transporter
ACWT_4962	COG1649	PFAM Uncharacterised BCR, COG1649
ACWT_4963	COG0297	glycogen (starch) synthase activity
ACWT_4964	COG5001	Diguanylate cyclase
ACWT_4965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACWT_4970	COG2816	NAD+ diphosphatase activity
ACWT_4979	COG2501	S4 domain
ACWT_4982	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACWT_4983	COG1366	Belongs to the anti-sigma-factor antagonist family
ACWT_4984	COG1940	carbohydrate kinase activity
ACWT_4987	COG4214	carbohydrate transport
ACWT_4988	COG1129	ABC transporter
ACWT_4990	COG2160	L-arabinose isomerase activity
ACWT_4991	COG1609	Transcriptional regulator
ACWT_4998	COG3706	GGDEF domain
ACWT_4999	COG5006	permease, DMT superfamily
ACWT_5000	COG1136	(ABC) transporter
ACWT_5000	COG0577	efflux transmembrane transporter activity
ACWT_5001	COG0577	efflux transmembrane transporter activity
ACWT_5001	COG1136	(ABC) transporter
ACWT_5007	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACWT_5009	COG0840	transmembrane signaling receptor activity
ACWT_5010	COG2198	Histidine kinase
ACWT_5010	COG0643	Histidine kinase
ACWT_5011	COG2201	protein-glutamate methylesterase activity
ACWT_5012	COG3706	GGDEF domain
ACWT_5012	COG0745	RESPONSE REGULATOR receiver
ACWT_5013	COG1136	(ABC) transporter
ACWT_5013	COG0577	efflux transmembrane transporter activity
ACWT_5014	COG0577	efflux transmembrane transporter activity
ACWT_5014	COG1136	(ABC) transporter
ACWT_5016	COG2197	response regulator
ACWT_5023	COG1086	Polysaccharide biosynthesis protein
ACWT_5030	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACWT_5034	COG3119	arylsulfatase activity
ACWT_5036	COG0671	phosphoesterase, PA-phosphatase related
ACWT_5037	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACWT_5040	COG1960	acyl-CoA dehydrogenase activity
ACWT_5041	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACWT_5043	COG2226	methyltransferase
ACWT_5054	COG1309	transcriptional regulator
ACWT_5057	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACWT_5058	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACWT_5059	COG1120	ATPase activity
ACWT_5061	COG0579	oxidoreductase
ACWT_5062	COG2205	protein histidine kinase activity
ACWT_5063	COG0745	RESPONSE REGULATOR receiver
ACWT_5064	COG1053	succinate dehydrogenase
ACWT_5064	COG3976	FMN-binding domain protein
ACWT_5064	COG0431	NADPH-dependent FMN reductase
ACWT_5065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACWT_5065	COG1017	nitric oxide dioxygenase activity
ACWT_5067	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACWT_5073	COG2771	luxR family
ACWT_5073	COG2200	EAL domain
ACWT_5074	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_5076	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACWT_5086	COG1022	Amp-dependent synthetase and ligase
ACWT_5089	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACWT_5092	COG4581	dead DEAH box helicase
ACWT_5093	COG0546	phosphoglycolate phosphatase activity
ACWT_5097	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACWT_5099	COG2378	regulation of single-species biofilm formation
ACWT_5101	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACWT_5108	COG3706	GGDEF domain
ACWT_5111	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACWT_5112	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACWT_5113	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACWT_5115	COG4122	O-methyltransferase activity
ACWT_5117	COG1222	aaa ATPase
ACWT_5121	COG1994	Peptidase M50
ACWT_5121	COG0517	IMP dehydrogenase activity
ACWT_5123	COG2197	response regulator
ACWT_5125	COG1136	(ABC) transporter
ACWT_5125	COG0577	efflux transmembrane transporter activity
ACWT_5126	COG0577	efflux transmembrane transporter activity
ACWT_5126	COG1136	(ABC) transporter
ACWT_5134	COG2197	response regulator
ACWT_5136	COG0215	cysteine-tRNA ligase activity
ACWT_5140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_5141	COG0667	Aldo Keto reductase
ACWT_5142	COG4585	Histidine kinase
ACWT_5146	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_5152	COG0542	response to heat
ACWT_5161	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACWT_5163	COG0745	RESPONSE REGULATOR receiver
ACWT_5164	COG0653	protein targeting
ACWT_5172	COG1797	cobyrinic acid a,c-diamide synthase activity
ACWT_5177	COG0640	Transcriptional regulator
ACWT_5180	COG5001	Diguanylate cyclase
ACWT_5182	COG0708	Exodeoxyribonuclease III
ACWT_5188	COG1643	Atp-dependent helicase
ACWT_5190	COG0745	RESPONSE REGULATOR receiver
ACWT_5191	COG4251	negative regulation of phosphorylation
ACWT_5202	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACWT_5204	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACWT_5206	COG2183	response to ionizing radiation
ACWT_5215	COG5297	Belongs to the glycosyl hydrolase family 6
ACWT_5218	COG5001	Diguanylate cyclase
ACWT_5220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACWT_5223	COG2197	response regulator
ACWT_5224	COG4585	Histidine kinase
ACWT_5225	COG0584	glycerophosphoryl diester phosphodiesterase
ACWT_5232	COG5001	Diguanylate cyclase
ACWT_5232	COG5002	protein histidine kinase activity
ACWT_5232	COG3447	MASE1 domain protein
ACWT_5234	COG0515	serine threonine protein kinase
ACWT_5238	COG1609	Transcriptional regulator
ACWT_5246	COG3866	Pectate lyase
ACWT_5248	COG0673	inositol 2-dehydrogenase activity
ACWT_5249	COG0246	Mannitol dehydrogenase
ACWT_5250	COG1904	glucuronate isomerase
ACWT_5251	COG0673	inositol 2-dehydrogenase activity
ACWT_5252	COG1609	Transcriptional regulator
ACWT_5254	COG1175	transmembrane transport
ACWT_5255	COG0395	ABC-type sugar transport system, permease component
ACWT_5258	COG0686	Belongs to the AlaDH PNT family
ACWT_5261	COG2197	response regulator
ACWT_5272	COG1486	melibiose metabolic process
ACWT_5273	COG1653	transport
ACWT_5276	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACWT_5284	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACWT_5286	COG1595	DNA-templated transcription, initiation
ACWT_5294	COG1653	transport
ACWT_5295	COG0395	ABC-type sugar transport system, permease component
ACWT_5302	COG2409	Drug exporters of the RND superfamily
ACWT_5310	COG2160	L-arabinose isomerase activity
ACWT_5311	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACWT_5312	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACWT_5314	COG1879	ABC-type sugar transport system periplasmic component
ACWT_5315	COG1609	Transcriptional regulator
ACWT_5317	COG0235	Class ii aldolase
ACWT_5321	COG2130	NADP-dependent
ACWT_5322	COG1309	transcriptional regulator
ACWT_5323	COG0569	domain protein
ACWT_5326	COG4251	negative regulation of phosphorylation
ACWT_5328	COG0840	transmembrane signaling receptor activity
ACWT_5331	COG1131	(ABC) transporter
ACWT_5343	COG0583	DNA-binding transcription factor activity
ACWT_5344	COG1012	belongs to the aldehyde dehydrogenase family
ACWT_5347	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACWT_5348	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACWT_5353	COG3458	cephalosporin-C deacetylase activity
ACWT_5354	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACWT_5357	COG0840	transmembrane signaling receptor activity
ACWT_5358	COG1461	Dihydroxyacetone kinase
ACWT_5359	COG2376	Dihydroxyacetone kinase
ACWT_5360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACWT_5360	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ACWT_5360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACWT_5365	COG4682	membrane
ACWT_5366	COG0183	Belongs to the thiolase family
ACWT_5367	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_5372	COG1309	transcriptional regulator
ACWT_5376	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_5377	COG1960	acyl-CoA dehydrogenase activity
ACWT_5381	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACWT_5381	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACWT_5383	COG1476	TRANSCRIPTIONal
ACWT_5384	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACWT_5386	COG1024	Enoyl-CoA hydratase
ACWT_5388	COG3940	Belongs to the glycosyl hydrolase 43 family
ACWT_5389	COG2199	diguanylate cyclase activity
ACWT_5389	COG2200	EAL domain
ACWT_5389	COG2202	Pas domain
ACWT_5392	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACWT_5393	COG2072	flavoprotein involved in K transport
ACWT_5395	COG0596	Alpha beta hydrolase
ACWT_5398	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACWT_5402	COG0477	Major facilitator Superfamily
ACWT_5403	COG1309	transcriptional regulator
ACWT_5407	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACWT_5410	COG3206	protein involved in exopolysaccharide biosynthesis
ACWT_5410	COG0489	protein tyrosine kinase activity
ACWT_5415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACWT_5416	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACWT_5420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACWT_5427	COG1252	NADH dehydrogenase
ACWT_5428	COG1435	thymidine kinase activity
ACWT_5430	COG1132	(ABC) transporter
ACWT_5431	COG1132	(ABC) transporter
ACWT_5435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACWT_5436	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACWT_5440	COG3548	integral membrane protein
ACWT_5448	COG3706	GGDEF domain
ACWT_5456	COG1609	Transcriptional regulator
ACWT_5459	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
ACWT_5466	COG0300	oxidoreductase activity
ACWT_5470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACWT_5480	COG0601	transmembrane transport
ACWT_5481	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACWT_5489	COG1053	succinate dehydrogenase
ACWT_5489	COG3976	FMN-binding domain protein
ACWT_5492	COG2755	lipolytic protein G-D-S-L family
ACWT_5496	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACWT_5498	COG1414	Transcriptional regulator
ACWT_5499	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACWT_5507	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACWT_5508	COG0438	transferase activity, transferring glycosyl groups
ACWT_5509	COG3206	protein involved in exopolysaccharide biosynthesis
ACWT_5509	COG0489	protein tyrosine kinase activity
ACWT_5526	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACWT_5528	COG1086	Polysaccharide biosynthesis protein
ACWT_5531	COG2197	response regulator
ACWT_5532	COG0477	Major facilitator Superfamily
ACWT_5534	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACWT_5536	COG4585	Histidine kinase
ACWT_5537	COG2197	response regulator
ACWT_5550	COG5001	Diguanylate cyclase
ACWT_5550	COG3300	MHYT domain
ACWT_5555	COG3511	phospholipase C
ACWT_5562	COG1132	(ABC) transporter
ACWT_5563	COG1132	(ABC) transporter
ACWT_5566	COG0745	RESPONSE REGULATOR receiver
ACWT_5567	COG2205	protein histidine kinase activity
ACWT_5570	COG2197	response regulator
ACWT_5573	COG1132	(ABC) transporter
ACWT_5576	COG1309	transcriptional regulator
ACWT_5579	COG5479	isomerase activity
ACWT_5579	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACWT_5580	COG0515	serine threonine protein kinase
ACWT_5582	COG0823	Involved in the tonB-independent uptake of proteins
ACWT_5582	COG1506	peptidase
ACWT_5604	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_5606	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACWT_5607	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_5616	COG1921	L-seryl-tRNASec selenium transferase activity
ACWT_5620	COG0709	Synthesizes selenophosphate from selenide and ATP
ACWT_5623	COG0437	4 iron, 4 sulfur cluster binding
ACWT_5624	COG0243	molybdopterin cofactor binding
ACWT_5624	COG3383	formate dehydrogenase (NAD+) activity
ACWT_5625	COG0243	molybdopterin cofactor binding
ACWT_5638	COG3104	oligopeptide transport
ACWT_5700	COG0305	Participates in initiation and elongation during chromosome replication
ACWT_5701	COG2801	Transposase and inactivated derivatives
ACWT_5701	COG3415	Transposase
ACWT_5702	COG0305	Participates in initiation and elongation during chromosome replication
ACWT_5712	COG2837	iron assimilation
ACWT_5732	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACWT_5742	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACWT_5777	COG0840	transmembrane signaling receptor activity
ACWT_5779	COG1902	pentaerythritol trinitrate reductase activity
ACWT_5790	COG1793	dna ligase
ACWT_5809	COG0358	DNA primase activity
ACWT_5824	COG3293	Transposase
ACWT_5836	COG3328	transposase activity
ACWT_5884	COG0739	heme binding
ACWT_5884	COG0741	lytic transglycosylase activity
ACWT_5884	COG1196	nuclear chromosome segregation
ACWT_5887	COG0642	Histidine kinase
ACWT_5888	COG0745	RESPONSE REGULATOR receiver
ACWT_5895	COG3547	Transposase (IS116 IS110 IS902 family)
ACWT_5896	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ACWT_5898	COG4974	Belongs to the 'phage' integrase family
ACWT_5905	COG3345	alpha-galactosidase
ACWT_5907	COG1609	Transcriptional regulator
ACWT_5913	COG0535	radical SAM domain protein
ACWT_5927	COG0477	Major facilitator Superfamily
ACWT_5934	COG3328	transposase activity
ACWT_5940	COG3629	intracellular signal transduction
ACWT_5940	COG3903	Transcriptional regulator
ACWT_5944	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACWT_5945	COG2267	carboxylic ester hydrolase activity
ACWT_5952	COG1509	lysine 2,3-aminomutase activity
ACWT_5958	COG3706	GGDEF domain
ACWT_5961	COG0395	ABC-type sugar transport system, permease component
ACWT_5962	COG1175	transmembrane transport
ACWT_5966	COG1674	ftsk spoiiie
ACWT_5968	COG2814	Major facilitator Superfamily
ACWT_5969	COG1846	Transcriptional regulator
ACWT_5980	COG1309	transcriptional regulator
ACWT_5983	COG0463	Glycosyl transferase, family 2
ACWT_5997	COG0515	serine threonine protein kinase
ACWT_6004	COG0745	RESPONSE REGULATOR receiver
ACWT_6007	COG3433	isochorismatase activity
ACWT_6007	COG2226	methyltransferase
ACWT_6007	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_6019	COG0475	glutathione-regulated potassium exporter activity
ACWT_6022	COG3629	intracellular signal transduction
ACWT_6022	COG3903	Transcriptional regulator
ACWT_6024	COG1021	2,3-dihydroxybenzoate-AMP ligase
ACWT_6026	COG3433	isochorismatase activity
ACWT_6026	COG2226	methyltransferase
ACWT_6026	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_6037	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_6038	COG1366	Belongs to the anti-sigma-factor antagonist family
ACWT_6049	COG3706	GGDEF domain
ACWT_6057	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACWT_6060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_6061	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_6062	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_6062	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_6062	COG3321	synthase
ACWT_6062	COG0300	oxidoreductase activity
ACWT_6062	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_6066	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACWT_6069	COG1162	GTPase activity
ACWT_6070	COG0745	RESPONSE REGULATOR receiver
ACWT_6071	COG5001	Diguanylate cyclase
ACWT_6071	COG3300	MHYT domain
ACWT_6074	COG4585	Histidine kinase
ACWT_6075	COG2197	response regulator
ACWT_6092	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACWT_6103	COG0367	asparagine synthase
ACWT_6106	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACWT_6110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACWT_6111	COG0019	diaminopimelate decarboxylase activity
ACWT_6117	COG1940	carbohydrate kinase activity
ACWT_6118	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACWT_6151	COG2826	transposase and inactivated derivatives, IS30 family
ACWT_6179	COG1160	GTP binding
ACWT_6180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACWT_6182	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACWT_6183	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACWT_6185	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_6187	COG2267	carboxylic ester hydrolase activity
ACWT_6189	COG1187	pseudouridine synthase activity
ACWT_6190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACWT_6191	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACWT_6199	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_6203	COG0686	Belongs to the AlaDH PNT family
ACWT_6208	COG1733	regulation of RNA biosynthetic process
ACWT_6214	COG0504	CTP synthase activity
ACWT_6222	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACWT_6229	COG0647	UMP catabolic process
ACWT_6231	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACWT_6232	COG2326	polyphosphate kinase activity
ACWT_6234	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACWT_6235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACWT_6236	COG1063	alcohol dehydrogenase
ACWT_6237	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACWT_6237	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACWT_6238	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACWT_6238	COG2213	PTS system mannitol-specific
ACWT_6239	COG2213	PTS system mannitol-specific
ACWT_6239	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACWT_6243	COG0477	Major facilitator Superfamily
ACWT_6244	COG0563	adenylate kinase activity
ACWT_6247	COG0010	Belongs to the arginase family
ACWT_6249	COG2340	Cysteine-rich secretory protein family
ACWT_6254	COG2094	Belongs to the DNA glycosylase MPG family
ACWT_6255	COG3973	AAA domain
ACWT_6256	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACWT_6264	COG0730	response to heat
ACWT_6267	COG3833	ABC-type maltose transport systems, permease component
ACWT_6270	COG1609	Transcriptional regulator
ACWT_6271	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_6272	COG0165	Argininosuccinate lyase
ACWT_6279	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACWT_6280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACWT_6281	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACWT_6282	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACWT_6291	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACWT_6293	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACWT_6300	COG2949	membrane
ACWT_6301	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACWT_6308	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACWT_6308	COG0072	phenylalanine-tRNA ligase activity
ACWT_6309	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACWT_6310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACWT_6311	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACWT_6312	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACWT_6313	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACWT_6315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACWT_6316	COG0140	phosphoribosyl-ATP diphosphatase activity
ACWT_6318	COG0765	amino acid transport
ACWT_6320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACWT_6321	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACWT_6321	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACWT_6327	COG0745	RESPONSE REGULATOR receiver
ACWT_6330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACWT_6331	COG0242	peptide deformylase activity
ACWT_6333	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACWT_6335	COG1758	RNA polymerase activity
ACWT_6336	COG0194	GDP metabolic process
ACWT_6338	COG0284	orotidine-5'-phosphate decarboxylase activity
ACWT_6339	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACWT_6340	COG0167	dihydroorotate dehydrogenase activity
ACWT_6342	COG0505	Belongs to the CarA family
ACWT_6343	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACWT_6344	COG0540	Belongs to the ATCase OTCase family
ACWT_6345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACWT_6347	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACWT_6348	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACWT_6349	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACWT_6350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACWT_6351	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACWT_6352	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACWT_6354	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACWT_6356	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACWT_6357	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACWT_6369	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACWT_6379	COG3964	amidohydrolase
ACWT_6380	COG0251	oxidation-reduction process
ACWT_6381	COG0515	serine threonine protein kinase
ACWT_6382	COG0831	urea catabolic process
ACWT_6383	COG0832	Belongs to the urease beta subunit family
ACWT_6388	COG0515	serine threonine protein kinase
ACWT_6391	COG1733	regulation of RNA biosynthetic process
ACWT_6393	COG0124	histidyl-tRNA synthetase
ACWT_6397	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACWT_6398	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACWT_6401	COG1862	Preprotein translocase
ACWT_6402	COG2255	four-way junction helicase activity
ACWT_6403	COG0632	four-way junction helicase activity
ACWT_6404	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACWT_6410	COG0217	transcriptional regulatory protein
ACWT_6411	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACWT_6412	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACWT_6414	COG0438	transferase activity, transferring glycosyl groups
ACWT_6415	COG1560	Kdo2-lipid A biosynthetic process
ACWT_6421	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACWT_6424	COG2205	protein histidine kinase activity
ACWT_6427	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACWT_6428	COG4106	trans-aconitate 2-methyltransferase activity
ACWT_6429	COG0667	Aldo Keto reductase
ACWT_6431	COG1278	Cold shock
ACWT_6438	COG1472	Belongs to the glycosyl hydrolase 3 family
ACWT_6440	COG0514	ATP-dependent DNA helicase (RecQ)
ACWT_6448	COG4585	Histidine kinase
ACWT_6451	COG0438	transferase activity, transferring glycosyl groups
ACWT_6470	COG0483	inositol monophosphate 1-phosphatase activity
ACWT_6472	COG0542	response to heat
ACWT_6474	COG2309	aminopeptidase activity
ACWT_6479	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACWT_6483	COG2351	hydroxyisourate hydrolase activity
ACWT_6484	COG1643	Atp-dependent helicase
ACWT_6485	COG2226	methyltransferase
ACWT_6490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACWT_6507	COG5002	protein histidine kinase activity
ACWT_6509	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACWT_6510	COG0823	Involved in the tonB-independent uptake of proteins
ACWT_6511	COG0405	Gamma-glutamyltransferase
ACWT_6515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACWT_6518	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACWT_6519	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_6520	COG1216	Glycosyl transferase, family 2
ACWT_6521	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACWT_6529	COG1686	Belongs to the peptidase S11 family
ACWT_6531	COG1191	sigma factor activity
ACWT_6532	COG2226	methyltransferase
ACWT_6533	COG3973	AAA domain
ACWT_6535	COG1191	sigma factor activity
ACWT_6536	COG0513	Belongs to the DEAD box helicase family
ACWT_6542	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACWT_6543	COG1609	Transcriptional regulator
ACWT_6545	COG4608	Belongs to the ABC transporter superfamily
ACWT_6546	COG0601	transmembrane transport
ACWT_6547	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACWT_6548	COG0444	Belongs to the ABC transporter superfamily
ACWT_6555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACWT_6556	COG0187	DNA topoisomerase II activity
ACWT_6558	COG2197	response regulator
ACWT_6560	COG2205	protein histidine kinase activity
ACWT_6561	COG0745	RESPONSE REGULATOR receiver
ACWT_6563	COG1846	Transcriptional regulator
ACWT_6564	COG0697	spore germination
ACWT_6566	COG0714	Associated with various cellular activities
ACWT_6569	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACWT_6584	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACWT_6590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACWT_6591	COG1017	nitric oxide dioxygenase activity
ACWT_6591	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACWT_6595	COG0395	ABC-type sugar transport system, permease component
ACWT_6599	COG2197	response regulator
ACWT_6602	COG0577	efflux transmembrane transporter activity
ACWT_6602	COG1136	(ABC) transporter
ACWT_6604	COG2755	lipolytic protein G-D-S-L family
ACWT_6607	COG0515	serine threonine protein kinase
ACWT_6609	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACWT_6610	COG1136	(ABC) transporter
ACWT_6613	COG0598	Magnesium transport protein CorA
ACWT_6614	COG3201	nicotinamide mononucleotide transporter
ACWT_6615	COG3135	benzoate transporter
ACWT_6620	COG0436	Aminotransferase
ACWT_6626	COG1673	EVE domain
ACWT_6633	COG3509	depolymerase
ACWT_6636	COG0577	efflux transmembrane transporter activity
ACWT_6636	COG1136	(ABC) transporter
ACWT_6638	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACWT_6655	COG0745	RESPONSE REGULATOR receiver
ACWT_6655	COG3706	GGDEF domain
ACWT_6656	COG2318	DinB family
ACWT_6662	COG0671	phosphoesterase, PA-phosphatase related
ACWT_6664	COG1597	lipid kinase activity
ACWT_6664	COG1803	Methylglyoxal synthase
ACWT_6670	COG0745	RESPONSE REGULATOR receiver
ACWT_6675	COG2197	response regulator
ACWT_6676	COG4585	Histidine kinase
ACWT_6681	COG1335	isochorismatase
ACWT_6683	COG0789	Transcriptional regulator
ACWT_6686	COG0800	Aldolase
ACWT_6693	COG0438	transferase activity, transferring glycosyl groups
ACWT_6694	COG0438	transferase activity, transferring glycosyl groups
ACWT_6699	COG0673	inositol 2-dehydrogenase activity
ACWT_6702	COG3483	tryptophan 2,3-dioxygenase activity
ACWT_6703	COG3012	SEC-C Motif Domain Protein
ACWT_6704	COG0840	transmembrane signaling receptor activity
ACWT_6708	COG0366	Alpha amylase catalytic
ACWT_6710	COG1175	transmembrane transport
ACWT_6711	COG1653	transport
ACWT_6713	COG0659	secondary active sulfate transmembrane transporter activity
ACWT_6715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_6715	COG2308	Evidence 4 Homologs of previously reported genes of
ACWT_6716	COG0367	asparagine synthase
ACWT_6718	COG0542	response to heat
ACWT_6722	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACWT_6726	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACWT_6737	COG2197	response regulator
ACWT_6738	COG4585	Histidine kinase
ACWT_6742	COG1131	(ABC) transporter
ACWT_6743	COG0328	RNA-DNA hybrid ribonuclease activity
ACWT_6750	COG1653	transport
ACWT_6751	COG1793	dna ligase
ACWT_6751	COG3285	dna ligase
ACWT_6753	COG4585	Histidine kinase
ACWT_6754	COG2197	response regulator
ACWT_6755	COG5001	Diguanylate cyclase
ACWT_6759	COG0071	Belongs to the small heat shock protein (HSP20) family
ACWT_6760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACWT_6761	COG1278	Cold shock
ACWT_6765	COG1595	DNA-templated transcription, initiation
ACWT_6768	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACWT_6772	COG0438	transferase activity, transferring glycosyl groups
ACWT_6773	COG0438	transferase activity, transferring glycosyl groups
ACWT_6777	COG0438	transferase activity, transferring glycosyl groups
ACWT_6778	COG1216	Glycosyl transferase, family 2
ACWT_6782	COG2807	transmembrane transport
ACWT_6785	COG4249	Peptidase C14 caspase catalytic subunit p20
ACWT_6785	COG2319	Wd-40 repeat
ACWT_6789	COG0058	SHG alpha-glucan phosphorylase activity
ACWT_6793	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACWT_6798	COG1960	acyl-CoA dehydrogenase activity
ACWT_6816	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACWT_6817	COG0714	Associated with various cellular activities
ACWT_6820	COG2304	oxidoreductase activity
ACWT_6826	COG5002	protein histidine kinase activity
ACWT_6828	COG0681	Belongs to the peptidase S26 family
ACWT_6829	COG1132	(ABC) transporter
ACWT_6834	COG4260	virion core protein, lumpy skin disease virus
ACWT_6844	COG2378	regulation of single-species biofilm formation
ACWT_6861	COG0543	2 iron, 2 sulfur cluster binding
ACWT_6861	COG0633	Ferredoxin
ACWT_6865	COG5001	Diguanylate cyclase
ACWT_6865	COG3300	MHYT domain
ACWT_6869	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ACWT_6881	COG1470	cell adhesion involved in biofilm formation
ACWT_6881	COG0366	Alpha amylase catalytic
ACWT_6887	COG1609	Transcriptional regulator
ACWT_6890	COG1960	acyl-CoA dehydrogenase activity
ACWT_6891	COG5001	Diguanylate cyclase
ACWT_6894	COG2197	response regulator
ACWT_6899	COG2409	Drug exporters of the RND superfamily
ACWT_6907	COG2264	protein methyltransferase activity
ACWT_6910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACWT_6911	COG0156	8-amino-7-oxononanoate synthase activity
ACWT_6912	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACWT_6918	COG0420	3'-5' exonuclease activity
ACWT_6919	COG0419	ATPase involved in DNA repair
ACWT_6932	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACWT_6940	COG1793	dna ligase
ACWT_6947	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACWT_6949	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACWT_6950	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACWT_6955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACWT_6957	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACWT_6958	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACWT_6959	COG0183	Belongs to the thiolase family
ACWT_6960	COG1024	Enoyl-CoA hydratase
ACWT_6960	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACWT_6962	COG2205	protein histidine kinase activity
ACWT_6963	COG0745	RESPONSE REGULATOR receiver
ACWT_6967	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACWT_6968	COG1301	dicarboxylic acid transport
ACWT_6969	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACWT_6970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACWT_6971	COG0531	amino acid
ACWT_6972	COG0569	domain protein
ACWT_6977	COG0756	dUTP diphosphatase activity
ACWT_6985	COG3447	MASE1 domain protein
ACWT_6985	COG5001	Diguanylate cyclase
ACWT_6985	COG5002	protein histidine kinase activity
ACWT_6987	COG2860	membrane
ACWT_6989	COG2313	pseudouridylate synthase activity
ACWT_6998	COG0643	Histidine kinase
ACWT_6998	COG2198	Histidine kinase
ACWT_7000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACWT_7002	COG2201	protein-glutamate methylesterase activity
ACWT_7003	COG0835	chemotaxis
ACWT_7006	COG1490	D-aminoacyl-tRNA deacylase activity
ACWT_7010	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACWT_7015	COG0738	Major facilitator superfamily
ACWT_7018	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACWT_7020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACWT_7022	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACWT_7024	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACWT_7025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACWT_7026	COG1196	nuclear chromosome segregation
ACWT_7029	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACWT_7033	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACWT_7035	COG1126	abc transporter atp-binding protein
ACWT_7036	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACWT_7038	COG0765	amino acid transport
ACWT_7039	COG1418	mRNA catabolic process
ACWT_7040	COG2137	regulation of response to DNA damage stimulus
ACWT_7041	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACWT_7043	COG1573	uracil-dna glycosylase
ACWT_7047	COG2815	serine threonine protein kinase
ACWT_7047	COG0515	serine threonine protein kinase
ACWT_7048	COG1201	RNA secondary structure unwinding
ACWT_7051	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACWT_7054	COG1396	sequence-specific DNA binding
ACWT_7055	COG1058	Belongs to the CinA family
ACWT_7055	COG1546	Belongs to the CinA family
ACWT_7057	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACWT_7060	COG1674	ftsk spoiiie
ACWT_7063	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACWT_7064	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACWT_7066	COG3214	Protein conserved in bacteria
ACWT_7067	COG0456	acetyltransferase
ACWT_7069	COG1278	Cold shock
ACWT_7071	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACWT_7072	COG0612	Peptidase, M16
ACWT_7073	COG1185	polyribonucleotide nucleotidyltransferase activity
ACWT_7074	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACWT_7077	COG0745	RESPONSE REGULATOR receiver
ACWT_7078	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACWT_7081	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACWT_7082	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACWT_7085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACWT_7089	COG0779	Required for maturation of 30S ribosomal subunits
ACWT_7097	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACWT_7098	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACWT_7100	COG1012	belongs to the aldehyde dehydrogenase family
ACWT_7104	COG1668	transmembrane transport
ACWT_7105	COG4152	abc transporter atp-binding protein
ACWT_7106	COG2197	response regulator
ACWT_7107	COG4585	Histidine kinase
ACWT_7111	COG1511	domain protein
ACWT_7112	COG3845	ABC transporter
ACWT_7114	COG0640	Transcriptional regulator
ACWT_7117	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACWT_7118	COG0750	zinc metalloprotease
ACWT_7123	COG2146	nitrite reductase [NAD(P)H] activity
ACWT_7123	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACWT_7126	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACWT_7128	COG0233	cytoplasmic translational termination
ACWT_7129	COG0528	UMP kinase activity
ACWT_7130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACWT_7131	COG0052	Belongs to the universal ribosomal protein uS2 family
ACWT_7132	COG0792	nuclease activity
ACWT_7133	COG0606	chelatase, subunit chli
ACWT_7143	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACWT_7144	COG0494	nUDIX hydrolase
ACWT_7145	COG0681	Belongs to the peptidase S26 family
ACWT_7146	COG0681	Belongs to the peptidase S26 family
ACWT_7147	COG0335	large ribosomal subunit rRNA binding
ACWT_7148	COG0336	Belongs to the RNA methyltransferase TrmD family
ACWT_7149	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACWT_7150	COG1837	Belongs to the UPF0109 family
ACWT_7151	COG0228	four-way junction DNA binding
ACWT_7153	COG0442	prolyl-tRNA aminoacylation
ACWT_7160	COG0438	transferase activity, transferring glycosyl groups
ACWT_7163	COG0463	Glycosyl transferase, family 2
ACWT_7165	COG2755	lipolytic protein G-D-S-L family
ACWT_7165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACWT_7168	COG1215	transferase activity, transferring glycosyl groups
ACWT_7171	COG1216	Glycosyl transferase, family 2
ACWT_7172	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACWT_7178	COG2318	DinB family
ACWT_7183	COG0438	transferase activity, transferring glycosyl groups
ACWT_7186	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACWT_7188	COG0571	ribonuclease III activity
ACWT_7190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACWT_7193	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACWT_7194	COG0742	ribosomal rna small subunit methyltransferase
ACWT_7198	COG1461	Dihydroxyacetone kinase
ACWT_7199	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACWT_7200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACWT_7204	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACWT_7207	COG0626	cystathionine gamma-synthase activity
ACWT_7208	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACWT_7212	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACWT_7215	COG0776	regulation of translation
ACWT_7216	COG0066	3-isopropylmalate dehydratase activity
ACWT_7219	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACWT_7220	COG1476	TRANSCRIPTIONal
ACWT_7222	COG1131	(ABC) transporter
ACWT_7226	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACWT_7227	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACWT_7231	COG0612	Peptidase, M16
ACWT_7232	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACWT_7235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACWT_7236	COG0473	3-isopropylmalate dehydrogenase activity
ACWT_7240	COG0440	acetolactate synthase activity
ACWT_7242	COG5001	Diguanylate cyclase
ACWT_7242	COG3300	MHYT domain
ACWT_7243	COG0129	dihydroxy-acid dehydratase activity
ACWT_7246	COG2132	Multicopper oxidase
ACWT_7250	COG1609	Transcriptional regulator
ACWT_7251	COG5001	Diguanylate cyclase
ACWT_7253	COG2133	pyrroloquinoline quinone binding
ACWT_7255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACWT_7257	COG0154	amidase activity
ACWT_7258	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACWT_7260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACWT_7262	COG0482	sulfurtransferase activity
ACWT_7264	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACWT_7266	COG2149	membrane
ACWT_7270	COG1595	DNA-templated transcription, initiation
ACWT_7272	COG0443	Heat shock 70 kDa protein
ACWT_7276	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACWT_7277	COG1119	ATPase activity
ACWT_7279	COG1472	Belongs to the glycosyl hydrolase 3 family
ACWT_7280	COG2902	Dehydrogenase
ACWT_7282	COG0010	Belongs to the arginase family
ACWT_7285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACWT_7287	COG1703	isobutyryl-CoA mutase activity
ACWT_7288	COG0183	Belongs to the thiolase family
ACWT_7292	COG3046	protein related to deoxyribodipyrimidine photolyase
ACWT_7295	COG4133	protoheme IX ABC transporter activity
ACWT_7301	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ACWT_7304	COG1674	ftsk spoiiie
ACWT_7306	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACWT_7313	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACWT_7315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACWT_7316	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACWT_7317	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACWT_7318	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACWT_7319	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACWT_7320	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACWT_7321	COG0356	it plays a direct role in the translocation of protons across the membrane
ACWT_7324	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACWT_7325	COG0702	epimerase
ACWT_7326	COG0251	oxidation-reduction process
ACWT_7328	COG0009	L-threonylcarbamoyladenylate synthase
ACWT_7331	COG2890	protein-(glutamine-N5) methyltransferase activity
ACWT_7332	COG3706	GGDEF domain
ACWT_7334	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACWT_7335	COG0254	rRNA binding
ACWT_7339	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ACWT_7341	COG0083	homoserine kinase activity
ACWT_7343	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACWT_7344	COG1846	Transcriptional regulator
ACWT_7345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACWT_7347	COG0460	homoserine dehydrogenase
ACWT_7349	COG0018	arginyl-trna synthetase
ACWT_7352	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACWT_7356	COG4166	transmembrane transport
ACWT_7357	COG3958	Transketolase
ACWT_7358	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACWT_7359	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACWT_7360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACWT_7363	COG0189	ligase activity
ACWT_7369	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACWT_7371	COG2815	serine threonine protein kinase
ACWT_7371	COG0515	serine threonine protein kinase
ACWT_7375	COG1733	regulation of RNA biosynthetic process
ACWT_7381	COG0673	inositol 2-dehydrogenase activity
ACWT_7385	COG0754	glutathionylspermidine amidase activity
ACWT_7391	COG3469	chitinase activity
ACWT_7394	COG0706	membrane insertase activity
ACWT_7396	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_7399	COG0740	serine-type endopeptidase activity
ACWT_7401	COG1834	amidinotransferase
ACWT_7402	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACWT_7410	COG2205	protein histidine kinase activity
ACWT_7411	COG0745	RESPONSE REGULATOR receiver
ACWT_7415	COG0567	Dehydrogenase, E1 component
ACWT_7415	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACWT_7417	COG0280	phosphate acetyltransferase
ACWT_7417	COG0857	belongs to the CobB CobQ family
ACWT_7418	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACWT_7424	COG2172	sigma factor antagonist activity
ACWT_7425	COG2188	Transcriptional regulator
ACWT_7427	COG1597	lipid kinase activity
ACWT_7430	COG0175	sulfate reduction
ACWT_7434	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACWT_7436	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ACWT_7438	COG1595	DNA-templated transcription, initiation
ACWT_7441	COG2135	peptidase activity
ACWT_7442	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACWT_7443	COG1162	GTPase activity
ACWT_7444	COG0483	inositol monophosphate 1-phosphatase activity
ACWT_7458	COG0861	Integral membrane protein TerC family
ACWT_7459	COG1357	PFAM Pentapeptide repeats (8 copies)
ACWT_7466	COG0477	Major facilitator Superfamily
ACWT_7467	COG3800	Transcriptional regulator
ACWT_7467	COG1396	sequence-specific DNA binding
ACWT_7469	COG1615	UPF0182 protein
ACWT_7470	COG3480	Lon protease (S16) C-terminal proteolytic domain
ACWT_7476	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACWT_7484	COG2816	NAD+ diphosphatase activity
ACWT_7487	COG1959	2 iron, 2 sulfur cluster binding
ACWT_7489	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ACWT_7490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACWT_7493	COG1278	Cold shock
ACWT_7496	COG0210	DNA helicase
ACWT_7496	COG0210	DNA helicase
ACWT_7497	COG1611	Belongs to the LOG family
ACWT_7498	COG1611	Belongs to the LOG family
ACWT_7501	COG2171	N-acyltransferase activity
ACWT_7511	COG4221	oxidoreductase activity
ACWT_7516	COG0456	acetyltransferase
ACWT_7519	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACWT_7520	COG0823	Involved in the tonB-independent uptake of proteins
ACWT_7520	COG1506	peptidase
ACWT_7522	COG0312	modulator of DNA gyrase
ACWT_7524	COG1053	succinate dehydrogenase
ACWT_7530	COG0410	ABC transporter
ACWT_7535	COG1028	Short-chain dehydrogenase reductase Sdr
ACWT_7537	COG1960	acyl-CoA dehydrogenase activity
ACWT_7540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACWT_7543	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_7557	COG0012	GTP binding
ACWT_7560	COG2169	Transcriptional regulator
ACWT_7560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACWT_7564	COG0525	valine-tRNA ligase activity
ACWT_7568	COG1322	Protein conserved in bacteria
ACWT_7569	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACWT_7571	COG1570	exodeoxyribonuclease VII activity
ACWT_7572	COG1722	exodeoxyribonuclease VII activity
ACWT_7578	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACWT_7579	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACWT_7579	COG0561	phosphatase activity
ACWT_7580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACWT_7581	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACWT_7582	COG1595	DNA-templated transcription, initiation
ACWT_7588	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACWT_7591	COG2815	serine threonine protein kinase
ACWT_7591	COG0515	serine threonine protein kinase
ACWT_7594	COG1404	Belongs to the peptidase S8 family
ACWT_7595	COG0424	maF-like protein
ACWT_7596	COG4770	biotin carboxylase activity
ACWT_7606	COG1473	amidohydrolase
ACWT_7606	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACWT_7607	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACWT_7607	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACWT_7608	COG0515	serine threonine protein kinase
ACWT_7608	COG2815	serine threonine protein kinase
ACWT_7609	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACWT_7612	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACWT_7617	COG0438	transferase activity, transferring glycosyl groups
ACWT_7622	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACWT_7624	COG1012	belongs to the aldehyde dehydrogenase family
ACWT_7625	COG1012	belongs to the aldehyde dehydrogenase family
ACWT_7631	COG2018	Roadblock/LC7 domain
ACWT_7633	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACWT_7646	COG0180	Tryptophanyl-tRNA synthetase
ACWT_7647	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACWT_7648	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACWT_7653	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACWT_7654	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACWT_7655	COG0193	aminoacyl-tRNA hydrolase activity
ACWT_7658	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACWT_7660	COG1309	transcriptional regulator
ACWT_7662	COG0488	(ABC) transporter
ACWT_7663	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACWT_7664	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACWT_7665	COG0084	hydrolase, TatD family'
ACWT_7667	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACWT_7672	COG0726	polysaccharide deacetylase
ACWT_7676	COG4974	Belongs to the 'phage' integrase family
ACWT_7679	COG0303	'Molybdopterin
ACWT_7680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACWT_7681	COG0745	RESPONSE REGULATOR receiver
ACWT_7681	COG3706	GGDEF domain
ACWT_7691	COG2095	MarC family integral membrane protein
ACWT_7692	COG0613	PHP domain protein
ACWT_7697	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACWT_7705	COG0384	phenazine biosynthesis protein PhzF
ACWT_7706	COG2239	Acts as a magnesium transporter
ACWT_7709	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACWT_7712	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACWT_7715	COG1024	Enoyl-CoA hydratase
ACWT_7717	COG0519	Catalyzes the synthesis of GMP from XMP
ACWT_7720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACWT_7721	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACWT_7721	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACWT_7722	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACWT_7723	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACWT_7728	COG3547	Transposase (IS116 IS110 IS902 family)
ACWT_7729	COG0113	porphobilinogen synthase activity
ACWT_7730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACWT_7730	COG1587	Uroporphyrinogen-III synthase
ACWT_7731	COG0181	hydroxymethylbilane synthase activity
ACWT_7732	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACWT_7733	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ACWT_7736	COG0318	PFAM AMP-dependent synthetase and ligase
ACWT_7737	COG1595	DNA-templated transcription, initiation
ACWT_7743	COG0506	proline dehydrogenase activity
ACWT_7745	COG1082	Xylose isomerase domain protein TIM barrel
ACWT_7750	COG0588	phosphoglycerate mutase activity
ACWT_7754	COG0438	transferase activity, transferring glycosyl groups
ACWT_7757	COG0745	RESPONSE REGULATOR receiver
ACWT_7760	COG5002	protein histidine kinase activity
ACWT_7763	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACWT_7764	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACWT_7766	COG4786	Flagellar basal body rod
ACWT_7766	COG1256	bacterial-type flagellum assembly
ACWT_7770	COG1516	flagellar protein fliS
ACWT_7772	COG1815	bacterial-type flagellum-dependent cell motility
ACWT_7773	COG1558	bacterial-type flagellum-dependent cell motility
ACWT_7774	COG1677	Flagellar hook-basal body complex protein FliE
ACWT_7776	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACWT_7778	COG1157	protein secretion by the type III secretion system
ACWT_7780	COG0739	heme binding
ACWT_7780	COG0741	lytic transglycosylase activity
ACWT_7780	COG1196	nuclear chromosome segregation
ACWT_7784	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACWT_7785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACWT_7787	COG1338	Plays a role in the flagellum-specific transport system
ACWT_7789	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACWT_7789	COG1776	CheC inhibitor of MCP methylation
ACWT_7790	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACWT_7792	COG1360	Flagellar Motor Protein
ACWT_7793	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACWT_7798	COG0745	RESPONSE REGULATOR receiver
ACWT_7802	COG2201	protein-glutamate methylesterase activity
ACWT_7805	COG0643	Histidine kinase
ACWT_7805	COG2198	Histidine kinase
ACWT_7806	COG0745	RESPONSE REGULATOR receiver
ACWT_7807	COG2340	Cysteine-rich secretory protein family
ACWT_7808	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACWT_7820	COG3246	L-lysine catabolic process to acetate
ACWT_7821	COG0354	folic acid binding
ACWT_7825	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ACWT_7831	COG1595	DNA-templated transcription, initiation
ACWT_7837	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACWT_7838	COG0581	inorganic phosphate transmembrane transporter activity
ACWT_7841	COG0456	acetyltransferase
ACWT_7842	COG0745	RESPONSE REGULATOR receiver
ACWT_7849	COG2339	peptidase activity
ACWT_7855	COG0459	protein refolding
ACWT_7858	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACWT_7860	COG1131	(ABC) transporter
ACWT_7861	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACWT_7864	COG1131	(ABC) transporter
ACWT_7865	COG1349	DNA-binding transcription factor activity
ACWT_7867	COG1940	carbohydrate kinase activity
ACWT_7869	COG1131	(ABC) transporter
ACWT_7872	COG2197	response regulator
ACWT_7883	COG3842	ATPase activity
ACWT_7888	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACWT_7889	COG0215	cysteine-tRNA ligase activity
ACWT_7890	COG1404	Belongs to the peptidase S8 family
ACWT_7891	COG0114	fumarate hydratase activity
ACWT_7892	COG3629	intracellular signal transduction
ACWT_7892	COG3903	Transcriptional regulator
ACWT_7894	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACWT_7894	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACWT_7897	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACWT_7899	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACWT_7901	COG1940	carbohydrate kinase activity
ACWT_7905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACWT_7906	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACWT_7911	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACWT_7914	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACWT_7915	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ACWT_7920	COG1194	a g-specific adenine glycosylase
ACWT_7925	COG0542	response to heat
ACWT_7927	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACWT_7928	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACWT_7930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACWT_7932	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACWT_7933	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACWT_7936	COG0649	NAD binding
ACWT_7939	COG1174	glycine betaine transport
ACWT_7940	COG1174	glycine betaine transport
ACWT_7947	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACWT_7953	COG1196	nuclear chromosome segregation
ACWT_7953	COG0741	lytic transglycosylase activity
ACWT_7953	COG0739	heme binding
ACWT_7955	COG1674	ftsk spoiiie
ACWT_7958	COG0302	gtp cyclohydrolase
ACWT_7959	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACWT_7961	COG0037	tRNA processing
ACWT_7964	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACWT_7966	COG1674	ftsk spoiiie
ACWT_7970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACWT_7972	COG2843	Capsule synthesis protein
ACWT_7975	COG0439	Biotin carboxylase
ACWT_7983	COG0003	Pfam Anion-transporting ATPase
ACWT_7985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACWT_7986	COG1610	YqeY-like protein
ACWT_7987	COG1408	metallophosphoesterase
ACWT_7989	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACWT_7993	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACWT_7996	COG4608	Belongs to the ABC transporter superfamily
ACWT_7999	COG0747	negative chemotaxis
ACWT_8001	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACWT_8006	COG0813	purine-nucleoside phosphorylase activity
ACWT_8007	COG0590	tRNA wobble adenosine to inosine editing
ACWT_8011	COG0287	Prephenate dehydrogenase
ACWT_8012	COG2318	DinB family
ACWT_8013	COG0235	Class ii aldolase
ACWT_8013	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACWT_8014	COG0501	Belongs to the peptidase M48B family
ACWT_8015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACWT_8015	COG1796	DNA polymerase
ACWT_8018	COG0642	Histidine kinase
ACWT_8019	COG2018	Roadblock/LC7 domain
ACWT_8029	COG3979	chitinase
ACWT_8032	COG0745	RESPONSE REGULATOR receiver
ACWT_8032	COG3706	GGDEF domain
ACWT_8041	COG0778	Nitroreductase
ACWT_8043	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACWT_8047	COG2205	protein histidine kinase activity
ACWT_8051	COG1268	BioY protein
ACWT_8056	COG0667	Aldo Keto reductase
ACWT_8059	COG1131	(ABC) transporter
ACWT_8061	COG1595	DNA-templated transcription, initiation
ACWT_8065	COG0673	inositol 2-dehydrogenase activity
ACWT_8066	COG0243	molybdopterin cofactor binding
ACWT_8068	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACWT_8070	COG1435	thymidine kinase activity
ACWT_8072	COG0443	Heat shock 70 kDa protein
ACWT_8079	COG2268	Band 7 protein
ACWT_8083	COG3979	chitinase
ACWT_8084	COG2199	diguanylate cyclase activity
ACWT_8084	COG2200	EAL domain
ACWT_8089	COG0148	phosphopyruvate hydratase activity
ACWT_8090	COG0789	Transcriptional regulator
ACWT_8098	COG1366	Belongs to the anti-sigma-factor antagonist family
ACWT_8100	COG2801	Transposase and inactivated derivatives
ACWT_8101	COG2801	Transposase and inactivated derivatives
ACWT_8101	COG3415	Transposase
ACWT_8103	COG2801	Transposase and inactivated derivatives
ACWT_8122	COG1881	PFAM PEBP family protein
ACWT_8129	COG0789	Transcriptional regulator
ACWT_8130	COG3959	Transketolase, thiamine diphosphate binding domain
ACWT_8131	COG3958	Transketolase
ACWT_8138	COG0598	Magnesium transport protein CorA
ACWT_8139	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACWT_8141	COG0371	Dehydrogenase
ACWT_8144	COG0438	transferase activity, transferring glycosyl groups
ACWT_8145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACWT_8148	COG3275	phosphorelay sensor kinase activity
ACWT_8151	COG2205	protein histidine kinase activity
ACWT_8154	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACWT_8162	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACWT_8175	COG1764	response to oxidative stress
ACWT_8177	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACWT_8178	COG0561	phosphatase activity
ACWT_8179	COG0561	phosphatase activity
ACWT_8181	COG1834	amidinotransferase
ACWT_8182	COG1522	sequence-specific DNA binding
ACWT_8186	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACWT_8190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACWT_8192	COG1408	metallophosphoesterase
ACWT_8193	COG0210	DNA helicase
ACWT_8201	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACWT_8201	COG0315	cyclic pyranopterin monophosphate synthase activity
ACWT_8202	COG0315	cyclic pyranopterin monophosphate synthase activity
ACWT_8203	COG5001	Diguanylate cyclase
ACWT_8207	COG0305	Participates in initiation and elongation during chromosome replication
ACWT_8209	COG0359	binds to the 23S rRNA
ACWT_8210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACWT_8211	COG0629	single-stranded DNA binding
ACWT_8212	COG0360	Binds together with S18 to 16S ribosomal RNA
ACWT_8217	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACWT_8219	COG1695	Transcriptional regulator
ACWT_8220	COG1260	myo-inositol-1-phosphate synthase
ACWT_8232	COG0617	tRNA 3'-terminal CCA addition
ACWT_8235	COG0515	serine threonine protein kinase
ACWT_8235	COG2815	serine threonine protein kinase
ACWT_8236	COG1595	DNA-templated transcription, initiation
ACWT_8239	COG3118	belongs to the thioredoxin family
ACWT_8240	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACWT_8240	COG3409	Peptidoglycan-binding domain 1 protein
ACWT_8242	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACWT_8243	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACWT_8247	COG1192	Involved in chromosome partitioning
ACWT_8248	COG0357	Ribosomal RNA small subunit methyltransferase G
ACWT_8250	COG0706	membrane insertase activity
ACWT_8251	COG0594	ribonuclease P activity
ACWT_8252	COG0230	Belongs to the bacterial ribosomal protein bL34 family