locus-tag	class	description
ACPL_1000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPL_1008	COG1132	(ABC) transporter
ACPL_1029	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_1034	COG1609	Transcriptional regulator
ACPL_1037	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_1041	COG1607	acyl-coa hydrolase
ACPL_1043	COG0438	transferase activity, transferring glycosyl groups
ACPL_1047	COG0778	Nitroreductase
ACPL_1047	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
ACPL_1050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPL_1056	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_1058	COG1515	deoxyribonuclease V activity
ACPL_1059	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACPL_1060	COG2835	tetraacyldisaccharide 4'-kinase activity
ACPL_1066	COG0745	RESPONSE REGULATOR receiver
ACPL_1067	COG5002	protein histidine kinase activity
ACPL_1070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACPL_1072	COG0653	protein targeting
ACPL_1078	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACPL_1079	COG2884	Cell division ATP-binding protein ftsE
ACPL_1080	COG2177	Part of the ABC transporter FtsEX involved in
ACPL_1081	COG0741	lytic transglycosylase activity
ACPL_1081	COG1196	nuclear chromosome segregation
ACPL_1081	COG0739	heme binding
ACPL_1082	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACPL_1112	COG1595	DNA-templated transcription, initiation
ACPL_1114	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACPL_1115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ACPL_1118	COG1678	Uncharacterized ACR, COG1678
ACPL_1119	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACPL_1121	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_1125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACPL_1129	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACPL_1150	COG5001	Diguanylate cyclase
ACPL_1150	COG5002	protein histidine kinase activity
ACPL_1154	COG3285	dna ligase
ACPL_1154	COG1793	dna ligase
ACPL_1155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_1156	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPL_1159	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_1161	COG1335	isochorismatase
ACPL_1162	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACPL_1163	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACPL_1169	COG1234	tRNA 3'-trailer cleavage
ACPL_117	COG0592	DNA-directed DNA polymerase activity
ACPL_1170	COG0438	transferase activity, transferring glycosyl groups
ACPL_1171	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACPL_1172	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACPL_1173	COG2986	histidine ammonia-lyase
ACPL_1174	COG1228	amidohydrolase
ACPL_1175	COG0402	S-adenosylhomocysteine deaminase activity
ACPL_1176	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_1177	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACPL_118	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACPL_1182	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACPL_119	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACPL_1190	COG1276	copper resistance
ACPL_1190	COG2372	response to copper ion
ACPL_1192	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACPL_120	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ACPL_1200	COG3226	Transcriptional regulator
ACPL_1208	COG2197	response regulator
ACPL_1211	COG2124	cytochrome p450
ACPL_1213	COG2255	four-way junction helicase activity
ACPL_1216	COG5002	protein histidine kinase activity
ACPL_1216	COG5001	Diguanylate cyclase
ACPL_123	COG0187	DNA topoisomerase II activity
ACPL_1234	COG0277	FAD linked oxidase domain protein
ACPL_1236	COG0745	RESPONSE REGULATOR receiver
ACPL_124	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACPL_1240	COG0598	Magnesium transport protein CorA
ACPL_1252	COG1609	Transcriptional regulator
ACPL_1253	COG2706	6-phosphogluconolactonase activity
ACPL_1256	COG2115	Belongs to the xylose isomerase family
ACPL_1257	COG1070	Carbohydrate kinase
ACPL_1259	COG0366	Alpha amylase catalytic
ACPL_1260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_1266	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACPL_1281	COG2197	response regulator
ACPL_1284	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACPL_129	COG2197	response regulator
ACPL_1292	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACPL_1293	COG1492	cobalamin metabolic process
ACPL_1294	COG0501	Belongs to the peptidase M48B family
ACPL_1295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_1298	COG1793	dna ligase
ACPL_130	COG4585	Histidine kinase
ACPL_1301	COG1797	cobyrinic acid a,c-diamide synthase activity
ACPL_1305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACPL_1306	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACPL_1306	COG1648	precorrin-2 dehydrogenase activity
ACPL_1307	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACPL_1316	COG0668	transmembrane transport
ACPL_1321	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACPL_1324	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACPL_1328	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACPL_1330	COG4552	Acetyltransferase involved in intracellular survival and related
ACPL_1334	COG0640	Transcriptional regulator
ACPL_1339	COG1595	DNA-templated transcription, initiation
ACPL_1340	COG0640	Transcriptional regulator
ACPL_1341	COG2814	Major facilitator Superfamily
ACPL_1346	COG1063	alcohol dehydrogenase
ACPL_1348	COG0693	protein deglycase activity
ACPL_1351	COG0494	nUDIX hydrolase
ACPL_1352	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACPL_1353	COG0740	serine-type endopeptidase activity
ACPL_1354	COG0740	serine-type endopeptidase activity
ACPL_1355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACPL_1357	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACPL_136	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACPL_1360	COG0525	valine-tRNA ligase activity
ACPL_1361	COG0285	dihydrofolate synthase activity
ACPL_1365	COG0105	UTP biosynthetic process
ACPL_1366	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACPL_1369	COG0596	Alpha beta hydrolase
ACPL_1374	COG1530	ribonuclease E activity
ACPL_1376	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACPL_1377	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACPL_1378	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACPL_1379	COG2153	protein acetylation
ACPL_1380	COG0180	Tryptophanyl-tRNA synthetase
ACPL_1383	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACPL_1385	COG0406	alpha-ribazole phosphatase activity
ACPL_1387	COG1307	EDD domain protein, DegV family
ACPL_1389	COG2890	protein-(glutamine-N5) methyltransferase activity
ACPL_1390	COG1596	polysaccharide export
ACPL_1390	COG1555	photosystem II stabilization
ACPL_1391	COG0658	competence protein
ACPL_1391	COG2333	competence protein COMEC
ACPL_1394	COG0268	Binds directly to 16S ribosomal RNA
ACPL_1398	COG0481	GTPase activity
ACPL_1399	COG2261	transglycosylase associated protein
ACPL_1405	COG1420	regulation of RNA biosynthetic process
ACPL_1406	COG0484	heat shock protein binding
ACPL_1408	COG1695	Transcriptional regulator
ACPL_141	COG0326	Molecular chaperone. Has ATPase activity
ACPL_1411	COG0537	adenosine 5'-monophosphoramidase activity
ACPL_1414	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACPL_1417	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACPL_1420	COG1381	Involved in DNA repair and RecF pathway recombination
ACPL_1421	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACPL_1428	COG1122	ATPase activity
ACPL_1430	COG2267	carboxylic ester hydrolase activity
ACPL_1435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACPL_1436	COG1121	(ABC) transporter
ACPL_1437	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACPL_144	COG0439	Biotin carboxylase
ACPL_1441	COG0423	glycine-tRNA ligase activity
ACPL_1443	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACPL_1443	COG3608	succinylglutamate desuccinylase aspartoacylase
ACPL_1447	COG2018	Roadblock/LC7 domain
ACPL_145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_1452	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACPL_1455	COG1131	(ABC) transporter
ACPL_1458	COG1295	ribonuclease BN
ACPL_1466	COG4115	mRNA cleavage
ACPL_1467	COG2161	toxin-antitoxin pair type II binding
ACPL_1472	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_1477	COG3469	chitinase activity
ACPL_1479	COG3250	beta-galactosidase activity
ACPL_148	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPL_149	COG1960	acyl-CoA dehydrogenase activity
ACPL_1492	COG2746	aminoglycoside 3-N-acetyltransferase activity
ACPL_1494	COG0641	radical SAM
ACPL_1496	COG3903	Transcriptional regulator
ACPL_1496	COG3629	intracellular signal transduction
ACPL_1499	COG3629	intracellular signal transduction
ACPL_1499	COG3903	Transcriptional regulator
ACPL_1504	COG0018	arginyl-trna synthetase
ACPL_1505	COG0737	Belongs to the 5'-nucleotidase family
ACPL_1508	COG0515	serine threonine protein kinase
ACPL_151	COG1846	Transcriptional regulator
ACPL_1512	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACPL_1515	COG3973	AAA domain
ACPL_1520	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_1523	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACPL_1524	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPL_1530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACPL_1531	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACPL_1532	COG0432	Pfam Uncharacterised protein family UPF0047
ACPL_1538	COG3557	Belongs to the UPF0374 family
ACPL_1543	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACPL_1545	COG0328	RNA-DNA hybrid ribonuclease activity
ACPL_1545	COG0406	alpha-ribazole phosphatase activity
ACPL_1551	COG0730	response to heat
ACPL_1553	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACPL_1554	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACPL_1557	COG2226	methyltransferase
ACPL_1561	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ACPL_1562	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACPL_1563	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACPL_1563	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACPL_1564	COG0174	glutamine synthetase
ACPL_1565	COG3766	membrane
ACPL_1567	COG2378	regulation of single-species biofilm formation
ACPL_1570	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACPL_1571	COG1846	Transcriptional regulator
ACPL_1574	COG1051	belongs to the nudix hydrolase family
ACPL_1586	COG0438	transferase activity, transferring glycosyl groups
ACPL_159	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACPL_160	COG1716	ATPase activity
ACPL_160	COG1716	ATPase activity
ACPL_1600	COG1674	ftsk spoiiie
ACPL_1608	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACPL_1608	COG1672	PFAM Archaeal ATPase
ACPL_161	COG1716	ATPase activity
ACPL_1610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACPL_1611	COG0017	Asparaginyl-tRNA synthetase
ACPL_1613	COG0321	lipoyl(octanoyl) transferase activity
ACPL_1616	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_1617	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_1618	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPL_1620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACPL_1621	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACPL_1622	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACPL_1623	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACPL_1625	COG1994	Peptidase M50
ACPL_1626	COG0667	Aldo Keto reductase
ACPL_1631	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACPL_1634	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACPL_1635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACPL_1636	COG1929	Belongs to the glycerate kinase type-1 family
ACPL_164	COG0768	penicillin binding
ACPL_1640	COG0425	Belongs to the sulfur carrier protein TusA family
ACPL_1641	COG1104	cysteine desulfurase activity
ACPL_1642	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACPL_1645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACPL_165	COG0515	serine threonine protein kinase
ACPL_1656	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACPL_1658	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_166	COG2815	serine threonine protein kinase
ACPL_166	COG0515	serine threonine protein kinase
ACPL_1662	COG0501	Belongs to the peptidase M48B family
ACPL_1663	COG0438	transferase activity, transferring glycosyl groups
ACPL_1665	COG1132	(ABC) transporter
ACPL_1670	COG2197	response regulator
ACPL_1674	COG1940	carbohydrate kinase activity
ACPL_1680	COG0204	Acyl-transferase
ACPL_1686	COG0205	6-phosphofructokinase activity
ACPL_1696	COG0386	Belongs to the glutathione peroxidase family
ACPL_1698	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACPL_1702	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACPL_1703	COG2815	serine threonine protein kinase
ACPL_1703	COG0515	serine threonine protein kinase
ACPL_1719	COG1309	transcriptional regulator
ACPL_172	COG0247	lactate metabolic process
ACPL_172	COG2181	nitrate reductase activity
ACPL_1721	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACPL_1722	COG1053	succinate dehydrogenase
ACPL_1724	COG0583	DNA-binding transcription factor activity
ACPL_1747	COG0714	Associated with various cellular activities
ACPL_1748	COG0495	leucyl-tRNA aminoacylation
ACPL_1750	COG3442	glutamine amidotransferase
ACPL_1751	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACPL_1753	COG2001	Belongs to the MraZ family
ACPL_1754	COG0275	rRNA processing
ACPL_1756	COG0768	penicillin binding
ACPL_1757	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACPL_1759	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACPL_1761	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACPL_1762	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACPL_1764	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACPL_1766	COG1799	cell septum assembly
ACPL_1768	COG3599	regulation of cell shape
ACPL_177	COG0717	Belongs to the dCTP deaminase family
ACPL_1772	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACPL_1776	COG0587	DNA-directed DNA polymerase activity
ACPL_1778	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACPL_1779	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACPL_1780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPL_1781	COG0131	Imidazoleglycerol-phosphate dehydratase
ACPL_1784	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACPL_1785	COG0107	imidazoleglycerol-phosphate synthase activity
ACPL_1789	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_1791	COG1022	Amp-dependent synthetase and ligase
ACPL_1792	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_1795	COG0531	amino acid
ACPL_1797	COG1132	(ABC) transporter
ACPL_1798	COG1132	(ABC) transporter
ACPL_1799	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACPL_180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACPL_1802	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACPL_1808	COG0159	tryptophan synthase activity
ACPL_181	COG2770	Histidine kinase
ACPL_181	COG2208	phosphoserine phosphatase activity
ACPL_1810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACPL_1813	COG0067	glutamate synthase
ACPL_1813	COG0069	glutamate synthase activity
ACPL_1813	COG0070	glutamate synthase
ACPL_1825	COG0765	amino acid transport
ACPL_183	COG1960	acyl-CoA dehydrogenase activity
ACPL_1831	COG2226	methyltransferase
ACPL_1832	COG0539	negative regulation of cytoplasmic translation
ACPL_1833	COG0237	dephospho-CoA kinase activity
ACPL_1833	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ACPL_1836	COG2329	Antibiotic biosynthesis monooxygenase
ACPL_1837	COG0861	Integral membrane protein TerC family
ACPL_1840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACPL_1841	COG0740	serine-type endopeptidase activity
ACPL_1844	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPL_1846	COG1162	GTPase activity
ACPL_1848	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPL_1850	COG0322	excinuclease ABC activity
ACPL_1851	COG1660	Displays ATPase and GTPase activities
ACPL_1853	COG1481	regulation of sporulation
ACPL_1854	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACPL_1855	COG0126	phosphoglycerate kinase activity
ACPL_1856	COG0149	triose-phosphate isomerase activity
ACPL_1857	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACPL_1861	COG0363	glucosamine-6-phosphate deaminase activity
ACPL_1864	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACPL_1865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACPL_1866	COG0109	protoheme IX farnesyltransferase activity
ACPL_1874	COG0396	ATPase activity
ACPL_1875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACPL_1876	COG0822	iron-sulfur transferase activity
ACPL_1883	COG0588	phosphoglycerate mutase activity
ACPL_1887	COG2321	neutral zinc metallopeptidase
ACPL_1890	COG1024	Enoyl-CoA hydratase
ACPL_1891	COG1132	(ABC) transporter
ACPL_1892	COG3663	DNA glycosylase
ACPL_1893	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_1896	COG1309	transcriptional regulator
ACPL_1898	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_1902	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACPL_1905	COG0006	proline dipeptidase activity
ACPL_1912	COG0714	Associated with various cellular activities
ACPL_1915	COG2197	response regulator
ACPL_1916	COG4585	Histidine kinase
ACPL_1918	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACPL_193	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_1934	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_1937	COG1365	unkown
ACPL_1938	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACPL_194	COG0022	dehydrogenase e1 component
ACPL_1941	COG1175	transmembrane transport
ACPL_1942	COG0395	ABC-type sugar transport system, permease component
ACPL_1944	COG1175	transmembrane transport
ACPL_1945	COG0395	ABC-type sugar transport system, permease component
ACPL_1946	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_1946	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_1948	COG3265	gluconokinase activity
ACPL_1953	COG4585	Histidine kinase
ACPL_1954	COG2197	response regulator
ACPL_1956	COG0745	RESPONSE REGULATOR receiver
ACPL_1956	COG3706	GGDEF domain
ACPL_1969	COG3304	Inner membrane component domain
ACPL_1975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACPL_1976	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPL_1978	COG1309	transcriptional regulator
ACPL_1981	COG1309	transcriptional regulator
ACPL_1982	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_1985	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_1987	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPL_1988	COG2815	serine threonine protein kinase
ACPL_1988	COG0515	serine threonine protein kinase
ACPL_1990	COG5634	Uncharacterized conserved protein (DUF2278)
ACPL_1995	COG1253	flavin adenine dinucleotide binding
ACPL_1996	COG0840	transmembrane signaling receptor activity
ACPL_200	COG0443	Heat shock 70 kDa protein
ACPL_2001	COG3706	GGDEF domain
ACPL_2009	COG1175	transmembrane transport
ACPL_201	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACPL_2012	COG2205	protein histidine kinase activity
ACPL_2013	COG2198	Histidine kinase
ACPL_2013	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_2013	COG0784	Response regulator, receiver
ACPL_2013	COG2205	protein histidine kinase activity
ACPL_2016	COG2205	protein histidine kinase activity
ACPL_202	COG0484	heat shock protein binding
ACPL_2020	COG5002	protein histidine kinase activity
ACPL_2020	COG3850	Histidine kinase
ACPL_2022	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACPL_2024	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACPL_2025	COG3387	PFAM Glycoside hydrolase 15-related
ACPL_2026	COG1525	nuclease
ACPL_2027	COG0667	Aldo Keto reductase
ACPL_203	COG0789	Transcriptional regulator
ACPL_2035	COG2192	nodulation
ACPL_2038	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPL_2042	COG1129	ABC transporter
ACPL_2044	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_2049	COG1316	TRANSCRIPTIONal
ACPL_2050	COG1216	Glycosyl transferase, family 2
ACPL_2050	COG0463	Glycosyl transferase, family 2
ACPL_2062	COG1378	Sugar-specific transcriptional regulator TrmB
ACPL_2067	COG3706	GGDEF domain
ACPL_2067	COG0745	RESPONSE REGULATOR receiver
ACPL_207	COG2814	Major facilitator Superfamily
ACPL_2070	COG2070	2-Nitropropane dioxygenase
ACPL_2076	COG0436	Aminotransferase
ACPL_208	COG0542	response to heat
ACPL_2082	COG0667	Aldo Keto reductase
ACPL_2109	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_2112	COG2203	Gaf domain
ACPL_2112	COG2199	diguanylate cyclase activity
ACPL_2115	COG1196	nuclear chromosome segregation
ACPL_2115	COG0741	lytic transglycosylase activity
ACPL_2115	COG0739	heme binding
ACPL_2118	COG0789	Transcriptional regulator
ACPL_212	COG0640	Transcriptional regulator
ACPL_2120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_2123	COG0243	molybdopterin cofactor binding
ACPL_2124	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACPL_2129	COG0438	transferase activity, transferring glycosyl groups
ACPL_2133	COG0439	Biotin carboxylase
ACPL_2139	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACPL_214	COG0586	Pfam SNARE associated Golgi protein
ACPL_2140	COG1070	Carbohydrate kinase
ACPL_2141	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACPL_2147	COG2193	ferroxidase activity
ACPL_2149	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACPL_215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACPL_2154	COG0395	ABC-type sugar transport system, permease component
ACPL_2155	COG1486	melibiose metabolic process
ACPL_2161	COG3537	Alpha-1,2-mannosidase
ACPL_2175	COG1960	acyl-CoA dehydrogenase activity
ACPL_2176	COG1063	alcohol dehydrogenase
ACPL_2177	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACPL_2178	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACPL_2180	COG2814	Major facilitator Superfamily
ACPL_2187	COG2175	clavaminate synthase activity
ACPL_2195	COG2814	Major facilitator Superfamily
ACPL_2198	COG2197	response regulator
ACPL_2199	COG4585	Histidine kinase
ACPL_2205	COG0745	RESPONSE REGULATOR receiver
ACPL_2225	COG0464	growth
ACPL_2228	COG0714	Associated with various cellular activities
ACPL_2244	COG0642	Histidine kinase
ACPL_2247	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_2253	COG2201	protein-glutamate methylesterase activity
ACPL_2258	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_226	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACPL_2265	COG0714	Associated with various cellular activities
ACPL_227	COG0151	Belongs to the GarS family
ACPL_2273	COG2205	protein histidine kinase activity
ACPL_2274	COG0784	Response regulator, receiver
ACPL_2274	COG2198	Histidine kinase
ACPL_2274	COG5002	protein histidine kinase activity
ACPL_2276	COG2226	methyltransferase
ACPL_2277	COG2814	Major facilitator Superfamily
ACPL_2281	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACPL_2282	COG3537	Alpha-1,2-mannosidase
ACPL_2287	COG0789	Transcriptional regulator
ACPL_2288	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACPL_2307	COG1609	Transcriptional regulator
ACPL_231	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACPL_2310	COG0477	Major facilitator Superfamily
ACPL_2313	COG3347	Dehydrogenase
ACPL_2313	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_2314	COG1070	Carbohydrate kinase
ACPL_2315	COG0247	lactate metabolic process
ACPL_2316	COG1139	Iron-sulfur cluster binding protein
ACPL_2317	COG1556	Lactate utilization protein
ACPL_2319	COG0745	RESPONSE REGULATOR receiver
ACPL_232	COG0047	phosphoribosylformylglycinamidine synthase activity
ACPL_2320	COG3852	Histidine kinase
ACPL_2323	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACPL_2324	COG0577	efflux transmembrane transporter activity
ACPL_2324	COG1136	(ABC) transporter
ACPL_2325	COG0577	efflux transmembrane transporter activity
ACPL_2325	COG1136	(ABC) transporter
ACPL_2329	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_233	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACPL_2332	COG4948	Mandelate Racemase Muconate Lactonizing
ACPL_2335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACPL_2349	COG0596	Alpha beta hydrolase
ACPL_2350	COG1116	anion transmembrane transporter activity
ACPL_2351	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_2352	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_2354	COG1414	Transcriptional regulator
ACPL_2358	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPL_2359	COG3706	GGDEF domain
ACPL_2366	COG1414	Transcriptional regulator
ACPL_2367	COG3485	protocatechuate 3,4-dioxygenase
ACPL_2368	COG3485	protocatechuate 3,4-dioxygenase
ACPL_237	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACPL_2370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACPL_2376	COG2197	response regulator
ACPL_238	COG0641	radical SAM
ACPL_2382	COG0039	L-malate dehydrogenase activity
ACPL_2387	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_2408	COG1396	sequence-specific DNA binding
ACPL_2411	COG1072	(Pantothenic acid kinase))
ACPL_2418	COG1960	acyl-CoA dehydrogenase activity
ACPL_2420	COG1960	acyl-CoA dehydrogenase activity
ACPL_2421	COG1051	belongs to the nudix hydrolase family
ACPL_2423	COG0789	Transcriptional regulator
ACPL_2427	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACPL_2428	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_2429	COG1609	Transcriptional regulator
ACPL_2431	COG1175	transmembrane transport
ACPL_2432	COG0395	ABC-type sugar transport system, permease component
ACPL_2433	COG1501	Belongs to the glycosyl hydrolase 31 family
ACPL_2437	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACPL_2439	COG1122	ATPase activity
ACPL_2442	COG0310	cobalt ion transport
ACPL_2443	COG5002	protein histidine kinase activity
ACPL_2446	COG0840	transmembrane signaling receptor activity
ACPL_2447	COG5002	protein histidine kinase activity
ACPL_245	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
ACPL_2451	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_2453	COG1129	ABC transporter
ACPL_2454	COG1879	ABC-type sugar transport system periplasmic component
ACPL_2458	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_2459	COG2815	serine threonine protein kinase
ACPL_2459	COG0515	serine threonine protein kinase
ACPL_2463	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPL_2464	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_2465	COG3842	ATPase activity
ACPL_2466	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACPL_2467	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACPL_2468	COG1177	transmembrane transport
ACPL_2469	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPL_2470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPL_2473	COG0745	RESPONSE REGULATOR receiver
ACPL_2475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPL_2478	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_2479	COG2208	phosphoserine phosphatase activity
ACPL_2480	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_2482	COG1175	transmembrane transport
ACPL_2484	COG1609	Transcriptional regulator
ACPL_2485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_2486	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACPL_2489	COG0840	transmembrane signaling receptor activity
ACPL_2490	COG3191	aminopeptidase activity
ACPL_2494	COG0702	epimerase
ACPL_2495	COG1733	regulation of RNA biosynthetic process
ACPL_2498	COG3300	MHYT domain
ACPL_2498	COG5001	Diguanylate cyclase
ACPL_2500	COG1024	Enoyl-CoA hydratase
ACPL_2500	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPL_2501	COG0183	Belongs to the thiolase family
ACPL_2502	COG1960	acyl-CoA dehydrogenase activity
ACPL_2506	COG1074	ATP-dependent DNA helicase activity
ACPL_2506	COG1074	ATP-dependent DNA helicase activity
ACPL_2513	COG2197	response regulator
ACPL_2515	COG4585	Histidine kinase
ACPL_2519	COG0601	transmembrane transport
ACPL_2525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_253	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ACPL_2531	COG0656	L-ascorbic acid biosynthetic process
ACPL_2541	COG1126	abc transporter atp-binding protein
ACPL_2543	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_2544	COG4521	taurine ABC transporter
ACPL_2547	COG0366	Alpha amylase catalytic
ACPL_2549	COG3237	CsbD-like
ACPL_2550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_2551	COG2409	Drug exporters of the RND superfamily
ACPL_2555	COG1132	(ABC) transporter
ACPL_2558	COG0372	Belongs to the citrate synthase family
ACPL_2561	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_2561	COG0596	Alpha beta hydrolase
ACPL_2569	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACPL_2570	COG2146	nitrite reductase [NAD(P)H] activity
ACPL_2571	COG2223	nitrite transmembrane transporter activity
ACPL_2576	COG1136	(ABC) transporter
ACPL_2577	COG1136	(ABC) transporter
ACPL_2578	COG0395	ABC-type sugar transport system, permease component
ACPL_2579	COG1175	transmembrane transport
ACPL_258	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPL_2580	COG1653	transport
ACPL_2581	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACPL_2583	COG5297	Belongs to the glycosyl hydrolase family 6
ACPL_2583	COG4733	cellulase activity
ACPL_2586	COG0009	L-threonylcarbamoyladenylate synthase
ACPL_2596	COG0583	DNA-binding transcription factor activity
ACPL_2601	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_2606	COG0024	Methionine aminopeptidase
ACPL_261	COG0515	serine threonine protein kinase
ACPL_2612	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACPL_2612	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACPL_2613	COG0494	nUDIX hydrolase
ACPL_2618	COG0456	acetyltransferase
ACPL_262	COG1595	DNA-templated transcription, initiation
ACPL_2620	COG1742	UPF0060 membrane protein
ACPL_264	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACPL_2647	COG0859	PFAM glycosyl transferase family 9
ACPL_2649	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACPL_2649	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACPL_265	COG1121	(ABC) transporter
ACPL_2650	COG0438	transferase activity, transferring glycosyl groups
ACPL_2652	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACPL_2654	COG2192	nodulation
ACPL_266	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACPL_2663	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_2667	COG3293	Transposase
ACPL_2668	COG3415	Transposase
ACPL_2668	COG2801	Transposase and inactivated derivatives
ACPL_2672	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACPL_2674	COG3973	AAA domain
ACPL_2676	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACPL_268	COG0640	Transcriptional regulator
ACPL_2681	COG0531	amino acid
ACPL_2689	COG0714	Associated with various cellular activities
ACPL_269	COG0701	Predicted permease
ACPL_2694	COG0028	Belongs to the TPP enzyme family
ACPL_2699	COG0783	Belongs to the Dps family
ACPL_2700	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_2701	COG3866	Pectate lyase
ACPL_2703	COG0242	peptide deformylase activity
ACPL_2710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACPL_2713	COG0436	Aminotransferase
ACPL_2719	COG5001	Diguanylate cyclase
ACPL_2719	COG3300	MHYT domain
ACPL_2722	COG1690	Belongs to the RtcB family
ACPL_2725	COG0701	Predicted permease
ACPL_2727	COG2201	protein-glutamate methylesterase activity
ACPL_2730	COG2201	protein-glutamate methylesterase activity
ACPL_2736	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACPL_2737	COG1984	allophanate hydrolase subunit 2
ACPL_2745	COG0596	Alpha beta hydrolase
ACPL_2746	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_2748	COG0411	ABC transporter
ACPL_2749	COG0410	ABC transporter
ACPL_2750	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACPL_2752	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_2753	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACPL_2755	COG0183	Belongs to the thiolase family
ACPL_2756	COG0583	DNA-binding transcription factor activity
ACPL_2758	COG0488	(ABC) transporter
ACPL_2763	COG0693	protein deglycase activity
ACPL_2769	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_2775	COG2080	2 iron, 2 sulfur cluster binding
ACPL_2776	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACPL_2777	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACPL_2779	COG4213	ABC transporter substrate-binding protein
ACPL_2780	COG4214	carbohydrate transport
ACPL_2783	COG0577	efflux transmembrane transporter activity
ACPL_2783	COG1136	(ABC) transporter
ACPL_2786	COG0778	Nitroreductase
ACPL_2789	COG0640	Transcriptional regulator
ACPL_279	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACPL_2798	COG0463	Glycosyl transferase, family 2
ACPL_2801	COG1607	acyl-coa hydrolase
ACPL_2802	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_2803	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACPL_2804	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ACPL_2805	COG0604	alcohol dehydrogenase
ACPL_2806	COG1509	lysine 2,3-aminomutase activity
ACPL_2814	COG1960	acyl-CoA dehydrogenase activity
ACPL_2815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_2816	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_2822	COG3511	phospholipase C
ACPL_2823	COG3300	MHYT domain
ACPL_2823	COG5001	Diguanylate cyclase
ACPL_2826	COG3706	GGDEF domain
ACPL_2830	COG3540	Alkaline phosphatase
ACPL_2832	COG1324	tolerance protein
ACPL_2834	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_2848	COG0667	Aldo Keto reductase
ACPL_2853	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_2861	COG0494	nUDIX hydrolase
ACPL_2863	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ACPL_2867	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_2874	COG1476	TRANSCRIPTIONal
ACPL_2876	COG3022	response to hydroperoxide
ACPL_2882	COG4279	zinc finger
ACPL_2883	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACPL_2885	COG5001	Diguanylate cyclase
ACPL_2885	COG3300	MHYT domain
ACPL_2889	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_2891	COG2124	cytochrome p450
ACPL_2894	COG0531	amino acid
ACPL_2895	COG0515	serine threonine protein kinase
ACPL_2901	COG1408	metallophosphoesterase
ACPL_2902	COG1132	(ABC) transporter
ACPL_2903	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_2906	COG2226	methyltransferase
ACPL_2907	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACPL_2908	COG2151	metal-sulfur cluster biosynthetic enzyme
ACPL_2909	COG3396	Phenylacetate-CoA oxygenase
ACPL_2910	COG3460	Phenylacetate-CoA oxygenase
ACPL_2911	COG3396	Phenylacetate-CoA oxygenase
ACPL_2914	COG0673	inositol 2-dehydrogenase activity
ACPL_2916	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_2918	COG1082	Xylose isomerase domain protein TIM barrel
ACPL_2919	COG3962	Belongs to the TPP enzyme family
ACPL_2920	COG3718	enzyme involved in inositol metabolism
ACPL_2923	COG3384	dioxygenase
ACPL_2924	COG0861	Integral membrane protein TerC family
ACPL_2928	COG1136	(ABC) transporter
ACPL_2928	COG0577	efflux transmembrane transporter activity
ACPL_2929	COG1136	(ABC) transporter
ACPL_2929	COG0577	efflux transmembrane transporter activity
ACPL_2931	COG2205	protein histidine kinase activity
ACPL_2932	COG0745	RESPONSE REGULATOR receiver
ACPL_2939	COG0406	alpha-ribazole phosphatase activity
ACPL_2941	COG1609	Transcriptional regulator
ACPL_2946	COG1940	carbohydrate kinase activity
ACPL_2951	COG4608	Belongs to the ABC transporter superfamily
ACPL_2952	COG0444	Belongs to the ABC transporter superfamily
ACPL_2953	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_2954	COG0601	transmembrane transport
ACPL_2958	COG0745	RESPONSE REGULATOR receiver
ACPL_2959	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACPL_2965	COG2076	Multidrug Resistance protein
ACPL_2967	COG1309	transcriptional regulator
ACPL_2974	COG0515	serine threonine protein kinase
ACPL_2978	COG0166	Belongs to the GPI family
ACPL_2979	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACPL_2991	COG3328	transposase activity
ACPL_2993	COG1228	amidohydrolase
ACPL_2994	COG1620	l-lactate permease
ACPL_3003	COG3693	PFAM glycoside hydrolase, family 10
ACPL_3005	COG3693	PFAM glycoside hydrolase, family 10
ACPL_3008	COG3507	Belongs to the glycosyl hydrolase 43 family
ACPL_3009	COG3345	alpha-galactosidase
ACPL_301	COG1971	Probably functions as a manganese efflux pump
ACPL_3012	COG5297	Belongs to the glycosyl hydrolase family 6
ACPL_3018	COG2205	protein histidine kinase activity
ACPL_3019	COG0745	RESPONSE REGULATOR receiver
ACPL_3021	COG0133	tryptophan synthase activity
ACPL_3022	COG0159	tryptophan synthase activity
ACPL_3028	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_3029	COG0791	NLP P60 protein
ACPL_3029	COG3883	PFAM NLP P60 protein
ACPL_3030	COG0501	Belongs to the peptidase M48B family
ACPL_3032	COG1271	oxidase subunit
ACPL_3033	COG1294	oxidase, subunit
ACPL_3034	COG4988	ABC transporter
ACPL_3036	COG0840	transmembrane signaling receptor activity
ACPL_3037	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACPL_3038	COG0477	Major facilitator Superfamily
ACPL_3047	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACPL_3050	COG1309	transcriptional regulator
ACPL_3056	COG0326	Molecular chaperone. Has ATPase activity
ACPL_306	COG5002	protein histidine kinase activity
ACPL_3062	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACPL_3066	COG0297	glycogen (starch) synthase activity
ACPL_3070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_3072	COG0514	ATP-dependent DNA helicase (RecQ)
ACPL_3075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACPL_3075	COG0574	Belongs to the PEP-utilizing enzyme family
ACPL_3077	COG0277	FAD linked oxidase domain protein
ACPL_3078	COG0277	FAD linked oxidase domain protein
ACPL_3079	COG0247	lactate metabolic process
ACPL_3080	COG2409	Drug exporters of the RND superfamily
ACPL_3082	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACPL_3083	COG4213	ABC transporter substrate-binding protein
ACPL_3091	COG0515	serine threonine protein kinase
ACPL_3091	COG2815	serine threonine protein kinase
ACPL_3100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACPL_3104	COG1522	sequence-specific DNA binding
ACPL_3119	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_312	COG1902	pentaerythritol trinitrate reductase activity
ACPL_3122	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_3123	COG0022	dehydrogenase e1 component
ACPL_3124	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACPL_3125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_3131	COG0673	inositol 2-dehydrogenase activity
ACPL_3132	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACPL_3133	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_3135	COG2226	methyltransferase
ACPL_3138	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACPL_3141	COG0456	acetyltransferase
ACPL_3142	COG0277	FAD linked oxidase domain protein
ACPL_3142	COG0247	lactate metabolic process
ACPL_3144	COG3629	intracellular signal transduction
ACPL_3144	COG3903	Transcriptional regulator
ACPL_3147	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACPL_3148	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACPL_3156	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPL_3159	COG4677	pectinesterase activity
ACPL_3185	COG4585	Histidine kinase
ACPL_3186	COG2197	response regulator
ACPL_3195	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACPL_3196	COG1737	Transcriptional regulator
ACPL_3197	COG3876	Protein conserved in bacteria
ACPL_3198	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACPL_3200	COG1175	transmembrane transport
ACPL_3207	COG2205	protein histidine kinase activity
ACPL_3208	COG0745	RESPONSE REGULATOR receiver
ACPL_3213	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_3214	COG1131	(ABC) transporter
ACPL_3221	COG2304	oxidoreductase activity
ACPL_3223	COG2197	response regulator
ACPL_3227	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_3228	COG0438	transferase activity, transferring glycosyl groups
ACPL_3239	COG2199	diguanylate cyclase activity
ACPL_3239	COG2200	EAL domain
ACPL_3239	COG3287	FIST C domain
ACPL_324	COG1131	(ABC) transporter
ACPL_3257	COG0431	NADPH-dependent FMN reductase
ACPL_3258	COG3795	YCII-related domain
ACPL_3259	COG4941	Belongs to the sigma-70 factor family
ACPL_326	COG0671	phosphoesterase, PA-phosphatase related
ACPL_3265	COG0387	Pfam Sodium calcium exchanger
ACPL_3268	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACPL_3268	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACPL_327	COG0745	RESPONSE REGULATOR receiver
ACPL_3272	COG0745	RESPONSE REGULATOR receiver
ACPL_3273	COG2205	protein histidine kinase activity
ACPL_3274	COG0667	Aldo Keto reductase
ACPL_328	COG2205	protein histidine kinase activity
ACPL_3282	COG1131	(ABC) transporter
ACPL_3286	COG1968	undecaprenyl-diphosphatase activity
ACPL_3293	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ACPL_3294	COG0586	Pfam SNARE associated Golgi protein
ACPL_3316	COG2755	lipolytic protein G-D-S-L family
ACPL_3327	COG2201	protein-glutamate methylesterase activity
ACPL_3328	COG2205	protein histidine kinase activity
ACPL_3329	COG0745	RESPONSE REGULATOR receiver
ACPL_333	COG0741	lytic transglycosylase activity
ACPL_333	COG0739	heme binding
ACPL_333	COG1196	nuclear chromosome segregation
ACPL_3339	COG4585	Histidine kinase
ACPL_3342	COG2814	Major facilitator Superfamily
ACPL_336	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPL_3362	COG5002	protein histidine kinase activity
ACPL_3374	COG5001	Diguanylate cyclase
ACPL_3374	COG3447	MASE1 domain protein
ACPL_3374	COG5002	protein histidine kinase activity
ACPL_3376	COG0784	Response regulator, receiver
ACPL_3376	COG2205	protein histidine kinase activity
ACPL_3376	COG5002	protein histidine kinase activity
ACPL_3377	COG5001	Diguanylate cyclase
ACPL_3377	COG3300	MHYT domain
ACPL_3383	COG3511	phospholipase C
ACPL_3389	COG1606	tRNA processing
ACPL_3395	COG4191	Histidine kinase
ACPL_3395	COG0784	Response regulator, receiver
ACPL_3397	COG3706	GGDEF domain
ACPL_3397	COG0745	RESPONSE REGULATOR receiver
ACPL_3408	COG4941	Belongs to the sigma-70 factor family
ACPL_3409	COG3706	GGDEF domain
ACPL_3413	COG3409	Peptidoglycan-binding domain 1 protein
ACPL_3415	COG5001	Diguanylate cyclase
ACPL_3417	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACPL_3423	COG0443	Heat shock 70 kDa protein
ACPL_3427	COG5002	protein histidine kinase activity
ACPL_3428	COG2199	diguanylate cyclase activity
ACPL_3428	COG2203	Gaf domain
ACPL_3430	COG0745	RESPONSE REGULATOR receiver
ACPL_3441	COG3706	GGDEF domain
ACPL_3442	COG3706	GGDEF domain
ACPL_3442	COG0745	RESPONSE REGULATOR receiver
ACPL_3447	COG1215	transferase activity, transferring glycosyl groups
ACPL_3448	COG5002	protein histidine kinase activity
ACPL_3452	COG0840	transmembrane signaling receptor activity
ACPL_3457	COG1295	ribonuclease BN
ACPL_3458	COG1309	transcriptional regulator
ACPL_3465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_3467	COG2205	protein histidine kinase activity
ACPL_3468	COG5002	protein histidine kinase activity
ACPL_3473	COG0515	serine threonine protein kinase
ACPL_3473	COG2815	serine threonine protein kinase
ACPL_3502	COG1090	epimerase
ACPL_351	COG0438	transferase activity, transferring glycosyl groups
ACPL_3519	COG5001	Diguanylate cyclase
ACPL_3520	COG3903	Transcriptional regulator
ACPL_3520	COG3629	intracellular signal transduction
ACPL_3523	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_3524	COG4251	negative regulation of phosphorylation
ACPL_3532	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ACPL_3533	COG5002	protein histidine kinase activity
ACPL_3536	COG1982	Orn Lys Arg decarboxylase major
ACPL_3537	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACPL_354	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACPL_3546	COG2801	Transposase and inactivated derivatives
ACPL_3560	COG0515	serine threonine protein kinase
ACPL_3568	COG2197	response regulator
ACPL_3578	COG1136	(ABC) transporter
ACPL_3578	COG0577	efflux transmembrane transporter activity
ACPL_3579	COG4585	Histidine kinase
ACPL_3581	COG0745	RESPONSE REGULATOR receiver
ACPL_3581	COG3706	GGDEF domain
ACPL_3583	COG0492	ferredoxin-NADP+ reductase activity
ACPL_359	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_3595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_3595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_3603	COG1335	isochorismatase
ACPL_3605	COG2267	carboxylic ester hydrolase activity
ACPL_3607	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_3614	COG5001	Diguanylate cyclase
ACPL_3614	COG3300	MHYT domain
ACPL_3618	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACPL_362	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_3623	COG0515	serine threonine protein kinase
ACPL_3623	COG2815	serine threonine protein kinase
ACPL_3626	COG1609	Transcriptional regulator
ACPL_363	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_3633	COG1309	transcriptional regulator
ACPL_3639	COG3209	COG3209 Rhs family protein
ACPL_3647	COG0840	transmembrane signaling receptor activity
ACPL_3652	COG4124	Belongs to the glycosyl hydrolase 26 family
ACPL_3654	COG1940	carbohydrate kinase activity
ACPL_3657	COG1846	Transcriptional regulator
ACPL_3658	COG3387	PFAM Glycoside hydrolase 15-related
ACPL_3660	COG3940	Belongs to the glycosyl hydrolase 43 family
ACPL_3666	COG1131	(ABC) transporter
ACPL_3667	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACPL_3670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACPL_3673	COG0561	phosphatase activity
ACPL_3675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_3676	COG1940	carbohydrate kinase activity
ACPL_3678	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_3679	COG1082	Xylose isomerase domain protein TIM barrel
ACPL_3680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACPL_3681	COG1088	dTDP-glucose 4,6-dehydratase activity
ACPL_3682	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ACPL_3686	COG1175	transmembrane transport
ACPL_3690	COG0702	epimerase
ACPL_3691	COG1733	regulation of RNA biosynthetic process
ACPL_3699	COG4251	negative regulation of phosphorylation
ACPL_3707	COG2205	protein histidine kinase activity
ACPL_3707	COG3437	response regulator, receiver
ACPL_3707	COG4999	Histidine kinase
ACPL_3707	COG3850	Histidine kinase
ACPL_3709	COG0840	transmembrane signaling receptor activity
ACPL_3711	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACPL_3716	COG0640	Transcriptional regulator
ACPL_372	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACPL_3731	COG1918	ferrous iron import across plasma membrane
ACPL_3731	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACPL_3732	COG1278	Cold shock
ACPL_3735	COG3979	chitinase
ACPL_3736	COG3469	chitinase activity
ACPL_3741	COG0745	RESPONSE REGULATOR receiver
ACPL_3742	COG2205	protein histidine kinase activity
ACPL_3743	COG2409	Drug exporters of the RND superfamily
ACPL_375	COG1136	(ABC) transporter
ACPL_3760	COG1597	lipid kinase activity
ACPL_3773	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACPL_379	COG0745	RESPONSE REGULATOR receiver
ACPL_3790	COG3300	MHYT domain
ACPL_3790	COG5001	Diguanylate cyclase
ACPL_3793	COG2261	transglycosylase associated protein
ACPL_380	COG0784	Response regulator, receiver
ACPL_380	COG2205	protein histidine kinase activity
ACPL_3803	COG4172	Belongs to the ABC transporter superfamily
ACPL_3808	COG1902	pentaerythritol trinitrate reductase activity
ACPL_3817	COG4585	Histidine kinase
ACPL_382	COG2172	sigma factor antagonist activity
ACPL_3821	COG1136	(ABC) transporter
ACPL_383	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_384	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_3845	COG0519	Catalyzes the synthesis of GMP from XMP
ACPL_3846	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACPL_3847	COG0596	Alpha beta hydrolase
ACPL_3849	COG2197	response regulator
ACPL_3850	COG4585	Histidine kinase
ACPL_3854	COG3706	GGDEF domain
ACPL_3858	COG0745	RESPONSE REGULATOR receiver
ACPL_3858	COG3706	GGDEF domain
ACPL_386	COG1970	mechanosensitive ion channel activity
ACPL_3868	COG1609	Transcriptional regulator
ACPL_3871	COG1175	transmembrane transport
ACPL_3872	COG0395	ABC-type sugar transport system, permease component
ACPL_3876	COG1132	(ABC) transporter
ACPL_3881	COG2259	Doxx family
ACPL_3892	COG0583	DNA-binding transcription factor activity
ACPL_3896	COG2226	methyltransferase
ACPL_3900	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_3909	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACPL_3910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_3911	COG1414	Transcriptional regulator
ACPL_3912	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_3913	COG4941	Belongs to the sigma-70 factor family
ACPL_3914	COG3795	YCII-related domain
ACPL_3916	COG2072	flavoprotein involved in K transport
ACPL_3922	COG5001	Diguanylate cyclase
ACPL_3942	COG3706	GGDEF domain
ACPL_3942	COG0745	RESPONSE REGULATOR receiver
ACPL_3947	COG0142	geranyltranstransferase activity
ACPL_3948	COG0477	Major facilitator Superfamily
ACPL_395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACPL_3950	COG0531	amino acid
ACPL_3953	COG0583	DNA-binding transcription factor activity
ACPL_3954	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_396	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACPL_3968	COG2124	cytochrome p450
ACPL_3970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACPL_3973	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_398	COG2205	protein histidine kinase activity
ACPL_398	COG0784	Response regulator, receiver
ACPL_3983	COG0628	permease
ACPL_3989	COG2909	trisaccharide binding
ACPL_399	COG0745	RESPONSE REGULATOR receiver
ACPL_3991	COG2909	trisaccharide binding
ACPL_3994	COG0531	amino acid
ACPL_3995	COG2235	arginine
ACPL_3996	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACPL_3997	COG0549	Belongs to the carbamate kinase family
ACPL_4004	COG0477	Major facilitator Superfamily
ACPL_4009	COG1597	lipid kinase activity
ACPL_4020	COG0531	amino acid
ACPL_4023	COG0477	Major facilitator Superfamily
ACPL_4028	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACPL_4029	COG0406	alpha-ribazole phosphatase activity
ACPL_403	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_4034	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACPL_4038	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACPL_404	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACPL_4046	COG0640	Transcriptional regulator
ACPL_4048	COG0745	RESPONSE REGULATOR receiver
ACPL_4049	COG5002	protein histidine kinase activity
ACPL_405	COG0406	alpha-ribazole phosphatase activity
ACPL_4055	COG0789	Transcriptional regulator
ACPL_406	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPL_407	COG0785	Cytochrome C biogenesis protein
ACPL_4070	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ACPL_4070	COG1672	PFAM Archaeal ATPase
ACPL_4072	COG3173	Aminoglycoside phosphotransferase
ACPL_4073	COG1309	transcriptional regulator
ACPL_409	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACPL_4095	COG2770	Histidine kinase
ACPL_4095	COG2208	phosphoserine phosphatase activity
ACPL_4099	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ACPL_411	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACPL_4117	COG2197	response regulator
ACPL_4120	COG4104	PAAR repeat-containing protein
ACPL_4122	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACPL_4128	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_413	COG0163	prenyltransferase activity
ACPL_4130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_4134	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACPL_4135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACPL_4136	COG2197	response regulator
ACPL_4141	COG1595	DNA-templated transcription, initiation
ACPL_4145	COG0463	Glycosyl transferase, family 2
ACPL_4149	COG0076	glutamate decarboxylase activity
ACPL_4159	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACPL_4161	COG2020	methyltransferase activity
ACPL_4162	COG1556	Lactate utilization protein
ACPL_4163	COG1139	Iron-sulfur cluster binding protein
ACPL_4164	COG0247	lactate metabolic process
ACPL_4165	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACPL_4167	COG1129	ABC transporter
ACPL_4168	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_4171	COG2186	Transcriptional regulator
ACPL_4174	COG2186	Transcriptional regulator
ACPL_4175	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_4177	COG3706	GGDEF domain
ACPL_4177	COG0745	RESPONSE REGULATOR receiver
ACPL_418	COG0513	Belongs to the DEAD box helicase family
ACPL_4185	COG2186	Transcriptional regulator
ACPL_4187	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_4189	COG2186	Transcriptional regulator
ACPL_4190	COG2267	carboxylic ester hydrolase activity
ACPL_4191	COG5002	protein histidine kinase activity
ACPL_4192	COG0745	RESPONSE REGULATOR receiver
ACPL_4195	COG0577	efflux transmembrane transporter activity
ACPL_4195	COG1136	(ABC) transporter
ACPL_4196	COG1136	(ABC) transporter
ACPL_4196	COG0577	efflux transmembrane transporter activity
ACPL_420	COG3883	PFAM NLP P60 protein
ACPL_420	COG0791	NLP P60 protein
ACPL_4201	COG0640	Transcriptional regulator
ACPL_421	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPL_4211	COG2226	methyltransferase
ACPL_4214	COG1595	DNA-templated transcription, initiation
ACPL_4219	COG0840	transmembrane signaling receptor activity
ACPL_4223	COG3795	YCII-related domain
ACPL_4224	COG4941	Belongs to the sigma-70 factor family
ACPL_4236	COG1309	transcriptional regulator
ACPL_4239	COG2197	response regulator
ACPL_4240	COG4585	Histidine kinase
ACPL_4243	COG2267	carboxylic ester hydrolase activity
ACPL_4245	COG3795	YCII-related domain
ACPL_4246	COG4941	Belongs to the sigma-70 factor family
ACPL_425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPL_4250	COG0681	Belongs to the peptidase S26 family
ACPL_4251	COG0583	DNA-binding transcription factor activity
ACPL_4254	COG1942	4-Oxalocrotonate Tautomerase
ACPL_426	COG1120	ATPase activity
ACPL_4265	COG4221	oxidoreductase activity
ACPL_4280	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_4283	COG0861	Integral membrane protein TerC family
ACPL_4290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPL_4296	COG1131	(ABC) transporter
ACPL_4297	COG0842	Transport permease protein
ACPL_4298	COG4585	Histidine kinase
ACPL_4299	COG2197	response regulator
ACPL_4300	COG1191	sigma factor activity
ACPL_4302	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_4303	COG0488	(ABC) transporter
ACPL_4304	COG4974	Belongs to the 'phage' integrase family
ACPL_4305	COG1968	undecaprenyl-diphosphatase activity
ACPL_4310	COG4974	Belongs to the 'phage' integrase family
ACPL_4311	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_4311	COG1506	peptidase
ACPL_4313	COG2226	methyltransferase
ACPL_432	COG3973	AAA domain
ACPL_4324	COG1522	sequence-specific DNA binding
ACPL_4327	COG0667	Aldo Keto reductase
ACPL_4335	COG2197	response regulator
ACPL_4339	COG2270	Major facilitator Superfamily
ACPL_4345	COG2076	Multidrug Resistance protein
ACPL_4349	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ACPL_435	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACPL_4351	COG4702	Belongs to the UPF0303 family
ACPL_4356	COG1846	Transcriptional regulator
ACPL_4357	COG1764	response to oxidative stress
ACPL_436	COG0667	Aldo Keto reductase
ACPL_437	COG4279	zinc finger
ACPL_4370	COG0019	diaminopimelate decarboxylase activity
ACPL_438	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACPL_4380	COG0667	Aldo Keto reductase
ACPL_4385	COG0714	Associated with various cellular activities
ACPL_4391	COG4221	oxidoreductase activity
ACPL_4406	COG0242	peptide deformylase activity
ACPL_4409	COG1595	DNA-templated transcription, initiation
ACPL_441	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACPL_4410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACPL_4412	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACPL_4412	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACPL_4413	COG0667	Aldo Keto reductase
ACPL_4416	COG2226	methyltransferase
ACPL_442	COG2226	methyltransferase
ACPL_4428	COG0672	)-iron permease
ACPL_4429	COG2822	iron ion transport
ACPL_4430	COG2837	iron assimilation
ACPL_4449	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_4456	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_446	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_4463	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACPL_4468	COG1278	Cold shock
ACPL_4469	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACPL_447	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_4471	COG2197	response regulator
ACPL_448	COG0649	NAD binding
ACPL_4486	COG0346	lactoylglutathione lyase activity
ACPL_4488	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_4489	COG0840	transmembrane signaling receptor activity
ACPL_4499	COG1819	glycosyl
ACPL_4503	COG1024	Enoyl-CoA hydratase
ACPL_4506	COG1024	Enoyl-CoA hydratase
ACPL_4507	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACPL_4507	COG1902	pentaerythritol trinitrate reductase activity
ACPL_4509	COG2814	Major facilitator Superfamily
ACPL_451	COG1034	ATP synthesis coupled electron transport
ACPL_4516	COG1760	l-serine dehydratase
ACPL_4517	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACPL_452	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACPL_4524	COG1733	regulation of RNA biosynthetic process
ACPL_4526	COG1309	transcriptional regulator
ACPL_453	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_4531	COG1132	(ABC) transporter
ACPL_4532	COG1132	(ABC) transporter
ACPL_4535	COG0515	serine threonine protein kinase
ACPL_4538	COG1215	transferase activity, transferring glycosyl groups
ACPL_454	COG0839	Belongs to the complex I subunit 6 family
ACPL_4544	COG3415	Transposase
ACPL_4544	COG2801	Transposase and inactivated derivatives
ACPL_4548	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_455	COG0713	ATP synthesis coupled electron transport
ACPL_4551	COG5001	Diguanylate cyclase
ACPL_4564	COG2197	response regulator
ACPL_4569	COG1733	regulation of RNA biosynthetic process
ACPL_4570	COG2910	NAD(P)H-binding
ACPL_4576	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_458	COG1007	ATP synthesis coupled electron transport
ACPL_4590	COG1881	PFAM PEBP family protein
ACPL_4598	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACPL_4601	COG0640	Transcriptional regulator
ACPL_4605	COG3447	MASE1 domain protein
ACPL_4605	COG5001	Diguanylate cyclase
ACPL_4605	COG5002	protein histidine kinase activity
ACPL_4609	COG0300	oxidoreductase activity
ACPL_4610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_4610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACPL_4615	COG5002	protein histidine kinase activity
ACPL_4616	COG2205	protein histidine kinase activity
ACPL_4616	COG2202	Pas domain
ACPL_4618	COG1175	transmembrane transport
ACPL_4620	COG0789	Transcriptional regulator
ACPL_4627	COG3706	GGDEF domain
ACPL_4627	COG0745	RESPONSE REGULATOR receiver
ACPL_463	COG1950	PFAM Membrane protein of
ACPL_4637	COG3467	pyridoxamine 5'-phosphate
ACPL_4640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_4643	COG0492	ferredoxin-NADP+ reductase activity
ACPL_4644	COG0640	Transcriptional regulator
ACPL_4646	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACPL_4657	COG2721	sulfolactate sulfo-lyase activity
ACPL_4661	COG1609	Transcriptional regulator
ACPL_4664	COG0784	Response regulator, receiver
ACPL_4666	COG1278	Cold shock
ACPL_4668	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACPL_4671	COG1260	myo-inositol-1-phosphate synthase
ACPL_4673	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACPL_4675	COG0583	DNA-binding transcription factor activity
ACPL_4686	COG5001	Diguanylate cyclase
ACPL_4692	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_4693	COG2890	protein-(glutamine-N5) methyltransferase activity
ACPL_4694	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_470	COG0596	Alpha beta hydrolase
ACPL_4703	COG5002	protein histidine kinase activity
ACPL_4704	COG0745	RESPONSE REGULATOR receiver
ACPL_4710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACPL_472	COG3291	Pkd domain containing protein
ACPL_472	COG4412	M6 family metalloprotease domain protein
ACPL_4725	COG5001	Diguanylate cyclase
ACPL_4725	COG3300	MHYT domain
ACPL_4726	COG1404	Belongs to the peptidase S8 family
ACPL_4727	COG4251	negative regulation of phosphorylation
ACPL_4728	COG1982	Orn Lys Arg decarboxylase major
ACPL_473	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACPL_4732	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACPL_4734	COG0778	Nitroreductase
ACPL_4738	COG2267	carboxylic ester hydrolase activity
ACPL_4749	COG2814	Major facilitator Superfamily
ACPL_4750	COG2011	ABC-type metal ion transport system permease component
ACPL_4751	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACPL_4759	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_4761	COG1695	Transcriptional regulator
ACPL_4766	COG1064	alcohol dehydrogenase
ACPL_4775	COG1476	TRANSCRIPTIONal
ACPL_4777	COG3629	intracellular signal transduction
ACPL_4777	COG3903	Transcriptional regulator
ACPL_4785	COG2357	RelA SpoT domain protein
ACPL_4791	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_4795	COG0438	transferase activity, transferring glycosyl groups
ACPL_4800	COG2205	protein histidine kinase activity
ACPL_4800	COG3850	Histidine kinase
ACPL_4800	COG4999	Histidine kinase
ACPL_4800	COG3437	response regulator, receiver
ACPL_4801	COG4251	negative regulation of phosphorylation
ACPL_4806	COG0745	RESPONSE REGULATOR receiver
ACPL_4809	COG2205	protein histidine kinase activity
ACPL_4809	COG0784	Response regulator, receiver
ACPL_4809	COG5002	protein histidine kinase activity
ACPL_4813	COG5001	Diguanylate cyclase
ACPL_4820	COG0300	oxidoreductase activity
ACPL_4822	COG0667	Aldo Keto reductase
ACPL_4834	COG1691	(AIR) carboxylase
ACPL_4836	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ACPL_484	COG1111	helicase
ACPL_484	COG1205	dead DEAH box helicase
ACPL_4844	COG0477	Major facilitator Superfamily
ACPL_4848	COG2226	methyltransferase
ACPL_485	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_4852	COG5002	protein histidine kinase activity
ACPL_487	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACPL_4874	COG4762	Protein conserved in bacteria
ACPL_4890	COG0477	Major facilitator Superfamily
ACPL_490	COG1754	DNA topoisomerase type I activity
ACPL_490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACPL_4903	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACPL_4907	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACPL_4910	COG3239	Fatty acid desaturase
ACPL_4913	COG1376	ErfK ybiS ycfS ynhG family protein
ACPL_4916	COG1595	DNA-templated transcription, initiation
ACPL_492	COG1309	transcriptional regulator
ACPL_4935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACPL_494	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACPL_4941	COG3693	PFAM glycoside hydrolase, family 10
ACPL_4945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACPL_4945	COG2755	lipolytic protein G-D-S-L family
ACPL_4948	COG0840	transmembrane signaling receptor activity
ACPL_4955	COG0583	DNA-binding transcription factor activity
ACPL_496	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACPL_4960	COG1309	transcriptional regulator
ACPL_4976	COG0393	Putative heavy-metal-binding
ACPL_4977	COG0393	Putative heavy-metal-binding
ACPL_4999	COG3415	Transposase
ACPL_4999	COG2801	Transposase and inactivated derivatives
ACPL_5010	COG1131	(ABC) transporter
ACPL_5011	COG1131	(ABC) transporter
ACPL_502	COG1774	PSP1 C-terminal conserved region
ACPL_5023	COG0515	serine threonine protein kinase
ACPL_5024	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_5025	COG0697	spore germination
ACPL_5026	COG1686	Belongs to the peptidase S11 family
ACPL_5032	COG1335	isochorismatase
ACPL_5038	COG0714	Associated with various cellular activities
ACPL_5040	COG1674	ftsk spoiiie
ACPL_5044	COG0745	RESPONSE REGULATOR receiver
ACPL_5044	COG3706	GGDEF domain
ACPL_5046	COG0714	Associated with various cellular activities
ACPL_5047	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACPL_5057	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACPL_5063	COG0745	RESPONSE REGULATOR receiver
ACPL_5064	COG2205	protein histidine kinase activity
ACPL_5068	COG0367	asparagine synthase
ACPL_5069	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPL_507	COG1404	Belongs to the peptidase S8 family
ACPL_5073	COG1716	ATPase activity
ACPL_5074	COG0509	glycine decarboxylation via glycine cleavage system
ACPL_5083	COG0640	Transcriptional regulator
ACPL_5084	COG4867	von Willebrand factor, type A
ACPL_5085	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ACPL_5086	COG0384	phenazine biosynthesis protein PhzF
ACPL_5087	COG5001	Diguanylate cyclase
ACPL_5087	COG3447	MASE1 domain protein
ACPL_5087	COG5002	protein histidine kinase activity
ACPL_5088	COG0488	(ABC) transporter
ACPL_5092	COG1649	PFAM Uncharacterised BCR, COG1649
ACPL_5093	COG0297	glycogen (starch) synthase activity
ACPL_5094	COG5001	Diguanylate cyclase
ACPL_5095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACPL_510	COG0738	Major facilitator superfamily
ACPL_5100	COG2816	NAD+ diphosphatase activity
ACPL_5109	COG2501	S4 domain
ACPL_5112	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACPL_5113	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_5114	COG1940	carbohydrate kinase activity
ACPL_5117	COG4214	carbohydrate transport
ACPL_5118	COG1129	ABC transporter
ACPL_5120	COG2160	L-arabinose isomerase activity
ACPL_5121	COG1609	Transcriptional regulator
ACPL_5128	COG3706	GGDEF domain
ACPL_5129	COG5006	permease, DMT superfamily
ACPL_5130	COG1136	(ABC) transporter
ACPL_5130	COG0577	efflux transmembrane transporter activity
ACPL_5131	COG0577	efflux transmembrane transporter activity
ACPL_5131	COG1136	(ABC) transporter
ACPL_5137	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACPL_5139	COG0840	transmembrane signaling receptor activity
ACPL_5140	COG2198	Histidine kinase
ACPL_5140	COG0643	Histidine kinase
ACPL_5141	COG2201	protein-glutamate methylesterase activity
ACPL_5142	COG3706	GGDEF domain
ACPL_5142	COG0745	RESPONSE REGULATOR receiver
ACPL_5143	COG1136	(ABC) transporter
ACPL_5143	COG0577	efflux transmembrane transporter activity
ACPL_5144	COG1136	(ABC) transporter
ACPL_5144	COG0577	efflux transmembrane transporter activity
ACPL_5146	COG2197	response regulator
ACPL_5153	COG1086	Polysaccharide biosynthesis protein
ACPL_5160	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACPL_5164	COG3119	arylsulfatase activity
ACPL_5166	COG0671	phosphoesterase, PA-phosphatase related
ACPL_5167	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACPL_5170	COG1960	acyl-CoA dehydrogenase activity
ACPL_5171	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_5173	COG2226	methyltransferase
ACPL_5184	COG1309	transcriptional regulator
ACPL_5187	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPL_5188	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACPL_5189	COG1120	ATPase activity
ACPL_519	COG1793	dna ligase
ACPL_519	COG3285	dna ligase
ACPL_5191	COG0579	oxidoreductase
ACPL_5192	COG2205	protein histidine kinase activity
ACPL_5193	COG0745	RESPONSE REGULATOR receiver
ACPL_5194	COG0431	NADPH-dependent FMN reductase
ACPL_5194	COG1053	succinate dehydrogenase
ACPL_5194	COG3976	FMN-binding domain protein
ACPL_5195	COG1017	nitric oxide dioxygenase activity
ACPL_5195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACPL_5197	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACPL_5203	COG2771	luxR family
ACPL_5203	COG2200	EAL domain
ACPL_5204	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_5206	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_521	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACPL_5216	COG1022	Amp-dependent synthetase and ligase
ACPL_5219	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACPL_5222	COG4581	dead DEAH box helicase
ACPL_5223	COG0546	phosphoglycolate phosphatase activity
ACPL_5227	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACPL_5229	COG2378	regulation of single-species biofilm formation
ACPL_5231	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACPL_5238	COG3706	GGDEF domain
ACPL_5241	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACPL_5242	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACPL_5243	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACPL_5245	COG4122	O-methyltransferase activity
ACPL_5247	COG1222	aaa ATPase
ACPL_5251	COG0517	IMP dehydrogenase activity
ACPL_5251	COG1994	Peptidase M50
ACPL_5253	COG2197	response regulator
ACPL_5255	COG0577	efflux transmembrane transporter activity
ACPL_5255	COG1136	(ABC) transporter
ACPL_5256	COG1136	(ABC) transporter
ACPL_5256	COG0577	efflux transmembrane transporter activity
ACPL_526	COG1061	Type III restriction enzyme res subunit
ACPL_5264	COG2197	response regulator
ACPL_5266	COG0215	cysteine-tRNA ligase activity
ACPL_5270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_5271	COG0667	Aldo Keto reductase
ACPL_5272	COG4585	Histidine kinase
ACPL_5276	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_5282	COG0542	response to heat
ACPL_529	COG1278	Cold shock
ACPL_5291	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACPL_5293	COG0745	RESPONSE REGULATOR receiver
ACPL_5294	COG0653	protein targeting
ACPL_530	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACPL_5302	COG1797	cobyrinic acid a,c-diamide synthase activity
ACPL_5307	COG0640	Transcriptional regulator
ACPL_5310	COG5001	Diguanylate cyclase
ACPL_5312	COG0708	Exodeoxyribonuclease III
ACPL_5318	COG1643	Atp-dependent helicase
ACPL_5320	COG0745	RESPONSE REGULATOR receiver
ACPL_5321	COG4251	negative regulation of phosphorylation
ACPL_5332	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACPL_5334	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_5336	COG2183	response to ionizing radiation
ACPL_5345	COG5297	Belongs to the glycosyl hydrolase family 6
ACPL_5348	COG5001	Diguanylate cyclase
ACPL_5350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_5353	COG2197	response regulator
ACPL_5354	COG4585	Histidine kinase
ACPL_5355	COG0584	glycerophosphoryl diester phosphodiesterase
ACPL_536	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACPL_5362	COG5002	protein histidine kinase activity
ACPL_5362	COG3447	MASE1 domain protein
ACPL_5362	COG5001	Diguanylate cyclase
ACPL_5369	COG1609	Transcriptional regulator
ACPL_537	COG2814	Major facilitator Superfamily
ACPL_5377	COG3866	Pectate lyase
ACPL_5379	COG0673	inositol 2-dehydrogenase activity
ACPL_5380	COG0246	Mannitol dehydrogenase
ACPL_5381	COG1904	glucuronate isomerase
ACPL_5382	COG0673	inositol 2-dehydrogenase activity
ACPL_5383	COG1609	Transcriptional regulator
ACPL_5385	COG1175	transmembrane transport
ACPL_5386	COG0395	ABC-type sugar transport system, permease component
ACPL_5389	COG0686	Belongs to the AlaDH PNT family
ACPL_539	COG2814	Major facilitator Superfamily
ACPL_5392	COG2197	response regulator
ACPL_5403	COG1486	melibiose metabolic process
ACPL_5404	COG1653	transport
ACPL_5407	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_5415	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACPL_5417	COG1595	DNA-templated transcription, initiation
ACPL_542	COG2252	PERMEase
ACPL_5425	COG1653	transport
ACPL_5426	COG0395	ABC-type sugar transport system, permease component
ACPL_543	COG1846	Transcriptional regulator
ACPL_5433	COG2409	Drug exporters of the RND superfamily
ACPL_544	COG2814	Major facilitator Superfamily
ACPL_5441	COG2160	L-arabinose isomerase activity
ACPL_5442	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_5443	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACPL_5445	COG1879	ABC-type sugar transport system periplasmic component
ACPL_5446	COG1609	Transcriptional regulator
ACPL_5448	COG0235	Class ii aldolase
ACPL_5452	COG2130	NADP-dependent
ACPL_5453	COG1309	transcriptional regulator
ACPL_5454	COG0569	domain protein
ACPL_5457	COG4251	negative regulation of phosphorylation
ACPL_5459	COG0840	transmembrane signaling receptor activity
ACPL_546	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ACPL_5462	COG1131	(ABC) transporter
ACPL_5474	COG0583	DNA-binding transcription factor activity
ACPL_5475	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_5478	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_5479	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACPL_548	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACPL_5484	COG3458	cephalosporin-C deacetylase activity
ACPL_5485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACPL_5488	COG0840	transmembrane signaling receptor activity
ACPL_5489	COG1461	Dihydroxyacetone kinase
ACPL_5490	COG2376	Dihydroxyacetone kinase
ACPL_5491	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACPL_5491	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_5491	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ACPL_5496	COG4682	membrane
ACPL_5497	COG0183	Belongs to the thiolase family
ACPL_5498	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_550	COG0259	pyridoxamine-phosphate oxidase activity
ACPL_5503	COG1309	transcriptional regulator
ACPL_5507	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_5508	COG1960	acyl-CoA dehydrogenase activity
ACPL_5512	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACPL_5512	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ACPL_5514	COG1476	TRANSCRIPTIONal
ACPL_5515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACPL_5517	COG1024	Enoyl-CoA hydratase
ACPL_5519	COG3940	Belongs to the glycosyl hydrolase 43 family
ACPL_552	COG2017	converts alpha-aldose to the beta-anomer
ACPL_5520	COG2199	diguanylate cyclase activity
ACPL_5520	COG2200	EAL domain
ACPL_5520	COG2202	Pas domain
ACPL_5523	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACPL_5524	COG2072	flavoprotein involved in K transport
ACPL_5526	COG0596	Alpha beta hydrolase
ACPL_5529	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACPL_5533	COG0477	Major facilitator Superfamily
ACPL_5534	COG1309	transcriptional regulator
ACPL_5538	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACPL_5541	COG0489	protein tyrosine kinase activity
ACPL_5541	COG3206	protein involved in exopolysaccharide biosynthesis
ACPL_5545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACPL_5546	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_5550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACPL_5557	COG1252	NADH dehydrogenase
ACPL_5558	COG1435	thymidine kinase activity
ACPL_5560	COG1132	(ABC) transporter
ACPL_5561	COG1132	(ABC) transporter
ACPL_5565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACPL_5566	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_5570	COG3548	integral membrane protein
ACPL_5578	COG3706	GGDEF domain
ACPL_558	COG3842	ATPase activity
ACPL_5586	COG1609	Transcriptional regulator
ACPL_5589	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
ACPL_5596	COG0300	oxidoreductase activity
ACPL_5600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPL_5610	COG0601	transmembrane transport
ACPL_5611	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_5619	COG3976	FMN-binding domain protein
ACPL_5619	COG1053	succinate dehydrogenase
ACPL_5622	COG2755	lipolytic protein G-D-S-L family
ACPL_5626	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_5628	COG1414	Transcriptional regulator
ACPL_5629	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACPL_5637	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACPL_5638	COG0438	transferase activity, transferring glycosyl groups
ACPL_5639	COG0489	protein tyrosine kinase activity
ACPL_5639	COG3206	protein involved in exopolysaccharide biosynthesis
ACPL_564	COG1134	teichoic acid transport
ACPL_564	COG1388	LysM domain
ACPL_5656	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACPL_5658	COG1086	Polysaccharide biosynthesis protein
ACPL_566	COG1309	transcriptional regulator
ACPL_5661	COG2197	response regulator
ACPL_5662	COG0477	Major facilitator Superfamily
ACPL_5664	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACPL_5666	COG4585	Histidine kinase
ACPL_5667	COG2197	response regulator
ACPL_5680	COG3300	MHYT domain
ACPL_5680	COG5001	Diguanylate cyclase
ACPL_5685	COG3511	phospholipase C
ACPL_5692	COG1132	(ABC) transporter
ACPL_5693	COG1132	(ABC) transporter
ACPL_5696	COG0745	RESPONSE REGULATOR receiver
ACPL_5697	COG2205	protein histidine kinase activity
ACPL_5700	COG2197	response regulator
ACPL_5703	COG1132	(ABC) transporter
ACPL_5706	COG1309	transcriptional regulator
ACPL_5709	COG5479	isomerase activity
ACPL_5709	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACPL_571	COG0477	Major facilitator Superfamily
ACPL_5710	COG0515	serine threonine protein kinase
ACPL_5712	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_5712	COG1506	peptidase
ACPL_5734	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_5736	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACPL_5737	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_5746	COG1921	L-seryl-tRNASec selenium transferase activity
ACPL_5750	COG0709	Synthesizes selenophosphate from selenide and ATP
ACPL_5753	COG0437	4 iron, 4 sulfur cluster binding
ACPL_5754	COG3383	formate dehydrogenase (NAD+) activity
ACPL_5754	COG0243	molybdopterin cofactor binding
ACPL_5755	COG0243	molybdopterin cofactor binding
ACPL_5768	COG3104	oligopeptide transport
ACPL_580	COG0745	RESPONSE REGULATOR receiver
ACPL_581	COG0604	alcohol dehydrogenase
ACPL_582	COG3850	Histidine kinase
ACPL_583	COG2197	response regulator
ACPL_5830	COG0305	Participates in initiation and elongation during chromosome replication
ACPL_5831	COG2801	Transposase and inactivated derivatives
ACPL_5831	COG3415	Transposase
ACPL_5832	COG0305	Participates in initiation and elongation during chromosome replication
ACPL_5843	COG2837	iron assimilation
ACPL_585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACPL_586	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACPL_5863	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACPL_587	COG3300	MHYT domain
ACPL_587	COG5001	Diguanylate cyclase
ACPL_5873	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACPL_589	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACPL_5908	COG0840	transmembrane signaling receptor activity
ACPL_5910	COG1902	pentaerythritol trinitrate reductase activity
ACPL_5921	COG1793	dna ligase
ACPL_594	COG0596	Alpha beta hydrolase
ACPL_5940	COG0358	DNA primase activity
ACPL_595	COG2119	membrane
ACPL_5955	COG3293	Transposase
ACPL_5967	COG3328	transposase activity
ACPL_599	COG0477	Major facilitator Superfamily
ACPL_6015	COG1196	nuclear chromosome segregation
ACPL_6015	COG0739	heme binding
ACPL_6015	COG0741	lytic transglycosylase activity
ACPL_6018	COG0642	Histidine kinase
ACPL_6019	COG0745	RESPONSE REGULATOR receiver
ACPL_6026	COG3547	Transposase (IS116 IS110 IS902 family)
ACPL_6027	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ACPL_6029	COG4974	Belongs to the 'phage' integrase family
ACPL_6037	COG3345	alpha-galactosidase
ACPL_6039	COG1609	Transcriptional regulator
ACPL_6045	COG0535	radical SAM domain protein
ACPL_6059	COG0477	Major facilitator Superfamily
ACPL_606	COG0586	Pfam SNARE associated Golgi protein
ACPL_6066	COG3328	transposase activity
ACPL_6072	COG3629	intracellular signal transduction
ACPL_6072	COG3903	Transcriptional regulator
ACPL_6076	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACPL_6077	COG2267	carboxylic ester hydrolase activity
ACPL_6084	COG1509	lysine 2,3-aminomutase activity
ACPL_609	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACPL_6090	COG3706	GGDEF domain
ACPL_6093	COG0395	ABC-type sugar transport system, permease component
ACPL_6094	COG1175	transmembrane transport
ACPL_6098	COG1674	ftsk spoiiie
ACPL_6100	COG2814	Major facilitator Superfamily
ACPL_6101	COG1846	Transcriptional regulator
ACPL_6112	COG1309	transcriptional regulator
ACPL_6115	COG0463	Glycosyl transferase, family 2
ACPL_6129	COG0515	serine threonine protein kinase
ACPL_6136	COG0745	RESPONSE REGULATOR receiver
ACPL_6139	COG2226	methyltransferase
ACPL_6139	COG3433	isochorismatase activity
ACPL_6139	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_6151	COG0475	glutathione-regulated potassium exporter activity
ACPL_6154	COG3903	Transcriptional regulator
ACPL_6154	COG3629	intracellular signal transduction
ACPL_6156	COG1021	2,3-dihydroxybenzoate-AMP ligase
ACPL_6158	COG2226	methyltransferase
ACPL_6158	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_6158	COG3433	isochorismatase activity
ACPL_6169	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_617	COG1309	transcriptional regulator
ACPL_6170	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_618	COG1131	(ABC) transporter
ACPL_6181	COG3706	GGDEF domain
ACPL_6189	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACPL_619	COG3559	Exporter of polyketide antibiotics
ACPL_6192	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_6193	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_6194	COG3321	synthase
ACPL_6194	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_6194	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_6194	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_6194	COG0300	oxidoreductase activity
ACPL_6198	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPL_6201	COG1162	GTPase activity
ACPL_6202	COG0745	RESPONSE REGULATOR receiver
ACPL_6203	COG3300	MHYT domain
ACPL_6203	COG5001	Diguanylate cyclase
ACPL_6206	COG4585	Histidine kinase
ACPL_6207	COG2197	response regulator
ACPL_6224	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACPL_623	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACPL_6235	COG0367	asparagine synthase
ACPL_6238	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACPL_6242	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACPL_6243	COG0019	diaminopimelate decarboxylase activity
ACPL_6249	COG1940	carbohydrate kinase activity
ACPL_6250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACPL_626	COG3795	YCII-related domain
ACPL_627	COG4941	Belongs to the sigma-70 factor family
ACPL_628	COG0840	transmembrane signaling receptor activity
ACPL_6283	COG2826	transposase and inactivated derivatives, IS30 family
ACPL_631	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACPL_6311	COG1160	GTP binding
ACPL_6312	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACPL_6314	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_6315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACPL_6317	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_6319	COG2267	carboxylic ester hydrolase activity
ACPL_632	COG2271	Major facilitator Superfamily
ACPL_6321	COG1187	pseudouridine synthase activity
ACPL_6322	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACPL_6323	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACPL_6331	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_6335	COG0686	Belongs to the AlaDH PNT family
ACPL_6340	COG1733	regulation of RNA biosynthetic process
ACPL_6346	COG0504	CTP synthase activity
ACPL_6354	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACPL_6361	COG0647	UMP catabolic process
ACPL_6364	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACPL_6365	COG2326	polyphosphate kinase activity
ACPL_6367	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACPL_6368	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_6369	COG1063	alcohol dehydrogenase
ACPL_6370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_6370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_6371	COG2213	PTS system mannitol-specific
ACPL_6371	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_6372	COG2213	PTS system mannitol-specific
ACPL_6372	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACPL_6376	COG0477	Major facilitator Superfamily
ACPL_6377	COG0563	adenylate kinase activity
ACPL_6380	COG0010	Belongs to the arginase family
ACPL_6382	COG2340	Cysteine-rich secretory protein family
ACPL_6387	COG2094	Belongs to the DNA glycosylase MPG family
ACPL_6388	COG3973	AAA domain
ACPL_6389	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACPL_6397	COG0730	response to heat
ACPL_640	COG2971	BadF BadG BcrA BcrD
ACPL_6400	COG3833	ABC-type maltose transport systems, permease component
ACPL_6403	COG1609	Transcriptional regulator
ACPL_6404	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_6405	COG0165	Argininosuccinate lyase
ACPL_641	COG1737	Transcriptional regulator
ACPL_6412	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACPL_6413	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACPL_6414	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACPL_6415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACPL_642	COG4821	SIS domain
ACPL_6424	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACPL_6426	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACPL_6433	COG2949	membrane
ACPL_6434	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_6441	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_6441	COG0072	phenylalanine-tRNA ligase activity
ACPL_6442	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACPL_6443	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACPL_6444	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACPL_6445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACPL_6446	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACPL_6448	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACPL_6449	COG0140	phosphoribosyl-ATP diphosphatase activity
ACPL_6451	COG0765	amino acid transport
ACPL_6453	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACPL_6454	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_6454	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_6460	COG0745	RESPONSE REGULATOR receiver
ACPL_6463	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACPL_6464	COG0242	peptide deformylase activity
ACPL_6466	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACPL_6468	COG1758	RNA polymerase activity
ACPL_6469	COG0194	GDP metabolic process
ACPL_6471	COG0284	orotidine-5'-phosphate decarboxylase activity
ACPL_6472	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACPL_6473	COG0167	dihydroorotate dehydrogenase activity
ACPL_6475	COG0505	Belongs to the CarA family
ACPL_6476	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACPL_6477	COG0540	Belongs to the ATCase OTCase family
ACPL_6478	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACPL_6480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACPL_6481	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACPL_6482	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACPL_6483	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACPL_6484	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACPL_6485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACPL_6487	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACPL_6489	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACPL_6490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACPL_650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACPL_6500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACPL_6510	COG3964	amidohydrolase
ACPL_6511	COG0251	oxidation-reduction process
ACPL_6512	COG0515	serine threonine protein kinase
ACPL_6513	COG0831	urea catabolic process
ACPL_6514	COG0832	Belongs to the urease beta subunit family
ACPL_6519	COG0515	serine threonine protein kinase
ACPL_6522	COG1733	regulation of RNA biosynthetic process
ACPL_6524	COG0124	histidyl-tRNA synthetase
ACPL_6528	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACPL_6529	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACPL_653	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACPL_6532	COG1862	Preprotein translocase
ACPL_6533	COG2255	four-way junction helicase activity
ACPL_6534	COG0632	four-way junction helicase activity
ACPL_6535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACPL_6541	COG0217	transcriptional regulatory protein
ACPL_6542	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACPL_6543	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACPL_6545	COG0438	transferase activity, transferring glycosyl groups
ACPL_6546	COG1560	Kdo2-lipid A biosynthetic process
ACPL_6552	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACPL_6555	COG2205	protein histidine kinase activity
ACPL_6558	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACPL_6559	COG4106	trans-aconitate 2-methyltransferase activity
ACPL_656	COG1595	DNA-templated transcription, initiation
ACPL_6560	COG0667	Aldo Keto reductase
ACPL_6562	COG1278	Cold shock
ACPL_6569	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_6571	COG0514	ATP-dependent DNA helicase (RecQ)
ACPL_6579	COG4585	Histidine kinase
ACPL_6582	COG0438	transferase activity, transferring glycosyl groups
ACPL_660	COG0745	RESPONSE REGULATOR receiver
ACPL_660	COG3706	GGDEF domain
ACPL_6601	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_6603	COG0542	response to heat
ACPL_6605	COG2309	aminopeptidase activity
ACPL_6609	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACPL_6613	COG2351	hydroxyisourate hydrolase activity
ACPL_6614	COG1643	Atp-dependent helicase
ACPL_6615	COG2226	methyltransferase
ACPL_662	COG3706	GGDEF domain
ACPL_662	COG0745	RESPONSE REGULATOR receiver
ACPL_6620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACPL_6637	COG5002	protein histidine kinase activity
ACPL_6639	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACPL_6640	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_6641	COG0405	Gamma-glutamyltransferase
ACPL_6645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACPL_6648	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_6649	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_6650	COG1216	Glycosyl transferase, family 2
ACPL_6651	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_6659	COG1686	Belongs to the peptidase S11 family
ACPL_6661	COG1191	sigma factor activity
ACPL_6662	COG2226	methyltransferase
ACPL_6663	COG3973	AAA domain
ACPL_6665	COG1191	sigma factor activity
ACPL_6666	COG0513	Belongs to the DEAD box helicase family
ACPL_6672	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACPL_6673	COG1609	Transcriptional regulator
ACPL_6675	COG4608	Belongs to the ABC transporter superfamily
ACPL_6676	COG0601	transmembrane transport
ACPL_6677	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACPL_6678	COG0444	Belongs to the ABC transporter superfamily
ACPL_6685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACPL_6686	COG0187	DNA topoisomerase II activity
ACPL_6688	COG2197	response regulator
ACPL_6690	COG2205	protein histidine kinase activity
ACPL_6691	COG0745	RESPONSE REGULATOR receiver
ACPL_6693	COG1846	Transcriptional regulator
ACPL_6694	COG0697	spore germination
ACPL_6696	COG0714	Associated with various cellular activities
ACPL_6699	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ACPL_670	COG2409	Drug exporters of the RND superfamily
ACPL_6714	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACPL_6720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACPL_6721	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACPL_6721	COG1017	nitric oxide dioxygenase activity
ACPL_6725	COG0395	ABC-type sugar transport system, permease component
ACPL_6729	COG2197	response regulator
ACPL_6732	COG1136	(ABC) transporter
ACPL_6732	COG0577	efflux transmembrane transporter activity
ACPL_6734	COG2755	lipolytic protein G-D-S-L family
ACPL_6737	COG0515	serine threonine protein kinase
ACPL_6739	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACPL_6740	COG1136	(ABC) transporter
ACPL_6743	COG0598	Magnesium transport protein CorA
ACPL_6744	COG3201	nicotinamide mononucleotide transporter
ACPL_6745	COG3135	benzoate transporter
ACPL_675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACPL_675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACPL_6750	COG0436	Aminotransferase
ACPL_6756	COG1673	EVE domain
ACPL_676	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACPL_6763	COG3509	depolymerase
ACPL_6766	COG0577	efflux transmembrane transporter activity
ACPL_6766	COG1136	(ABC) transporter
ACPL_6768	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ACPL_677	COG2203	Gaf domain
ACPL_677	COG2200	EAL domain
ACPL_677	COG2199	diguanylate cyclase activity
ACPL_678	COG3469	chitinase activity
ACPL_6785	COG3706	GGDEF domain
ACPL_6785	COG0745	RESPONSE REGULATOR receiver
ACPL_6786	COG2318	DinB family
ACPL_6792	COG0671	phosphoesterase, PA-phosphatase related
ACPL_6794	COG1597	lipid kinase activity
ACPL_6794	COG1803	Methylglyoxal synthase
ACPL_6800	COG0745	RESPONSE REGULATOR receiver
ACPL_6805	COG2197	response regulator
ACPL_6806	COG4585	Histidine kinase
ACPL_681	COG0583	DNA-binding transcription factor activity
ACPL_6811	COG1335	isochorismatase
ACPL_6813	COG0789	Transcriptional regulator
ACPL_6816	COG0800	Aldolase
ACPL_6823	COG0438	transferase activity, transferring glycosyl groups
ACPL_6824	COG0438	transferase activity, transferring glycosyl groups
ACPL_6829	COG0673	inositol 2-dehydrogenase activity
ACPL_683	COG1388	LysM domain
ACPL_6832	COG3483	tryptophan 2,3-dioxygenase activity
ACPL_6833	COG3012	SEC-C Motif Domain Protein
ACPL_6834	COG0840	transmembrane signaling receptor activity
ACPL_6838	COG0366	Alpha amylase catalytic
ACPL_684	COG3268	Saccharopine dehydrogenase
ACPL_6840	COG1175	transmembrane transport
ACPL_6841	COG1653	transport
ACPL_6843	COG0659	secondary active sulfate transmembrane transporter activity
ACPL_6845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_6845	COG2308	Evidence 4 Homologs of previously reported genes of
ACPL_6846	COG0367	asparagine synthase
ACPL_685	COG0275	rRNA processing
ACPL_6853	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACPL_6857	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACPL_6868	COG2197	response regulator
ACPL_6869	COG4585	Histidine kinase
ACPL_6873	COG1131	(ABC) transporter
ACPL_6874	COG0328	RNA-DNA hybrid ribonuclease activity
ACPL_6881	COG1653	transport
ACPL_6882	COG3285	dna ligase
ACPL_6882	COG1793	dna ligase
ACPL_6884	COG4585	Histidine kinase
ACPL_6885	COG2197	response regulator
ACPL_6886	COG5001	Diguanylate cyclase
ACPL_6890	COG0071	Belongs to the small heat shock protein (HSP20) family
ACPL_6891	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACPL_6892	COG1278	Cold shock
ACPL_6896	COG1595	DNA-templated transcription, initiation
ACPL_6899	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACPL_6903	COG0438	transferase activity, transferring glycosyl groups
ACPL_6904	COG0438	transferase activity, transferring glycosyl groups
ACPL_6908	COG0438	transferase activity, transferring glycosyl groups
ACPL_6909	COG1216	Glycosyl transferase, family 2
ACPL_691	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACPL_6913	COG2807	transmembrane transport
ACPL_6916	COG4249	Peptidase C14 caspase catalytic subunit p20
ACPL_6916	COG2319	Wd-40 repeat
ACPL_692	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACPL_6920	COG0058	SHG alpha-glucan phosphorylase activity
ACPL_6924	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACPL_6929	COG1960	acyl-CoA dehydrogenase activity
ACPL_693	COG2205	protein histidine kinase activity
ACPL_694	COG0745	RESPONSE REGULATOR receiver
ACPL_6947	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_6948	COG0714	Associated with various cellular activities
ACPL_6951	COG2304	oxidoreductase activity
ACPL_6957	COG5002	protein histidine kinase activity
ACPL_6959	COG0681	Belongs to the peptidase S26 family
ACPL_6960	COG1132	(ABC) transporter
ACPL_6965	COG4260	virion core protein, lumpy skin disease virus
ACPL_6975	COG2378	regulation of single-species biofilm formation
ACPL_699	COG2201	protein-glutamate methylesterase activity
ACPL_6992	COG0543	2 iron, 2 sulfur cluster binding
ACPL_6992	COG0633	Ferredoxin
ACPL_6996	COG5001	Diguanylate cyclase
ACPL_6996	COG3300	MHYT domain
ACPL_700	COG4251	negative regulation of phosphorylation
ACPL_7000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ACPL_701	COG0784	Response regulator, receiver
ACPL_7012	COG1470	cell adhesion involved in biofilm formation
ACPL_7012	COG0366	Alpha amylase catalytic
ACPL_7018	COG1609	Transcriptional regulator
ACPL_702	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_7021	COG1960	acyl-CoA dehydrogenase activity
ACPL_7022	COG5001	Diguanylate cyclase
ACPL_7025	COG2197	response regulator
ACPL_7030	COG2409	Drug exporters of the RND superfamily
ACPL_7038	COG2264	protein methyltransferase activity
ACPL_7041	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACPL_7042	COG0156	8-amino-7-oxononanoate synthase activity
ACPL_7043	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACPL_7049	COG0420	3'-5' exonuclease activity
ACPL_705	COG0515	serine threonine protein kinase
ACPL_705	COG2815	serine threonine protein kinase
ACPL_7050	COG0419	ATPase involved in DNA repair
ACPL_7063	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACPL_7071	COG1793	dna ligase
ACPL_7078	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACPL_708	COG0514	ATP-dependent DNA helicase (RecQ)
ACPL_7080	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACPL_7081	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACPL_7086	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACPL_7088	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_7089	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACPL_7090	COG0183	Belongs to the thiolase family
ACPL_7091	COG1024	Enoyl-CoA hydratase
ACPL_7091	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPL_7093	COG2205	protein histidine kinase activity
ACPL_7094	COG0745	RESPONSE REGULATOR receiver
ACPL_7098	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACPL_7099	COG1301	dicarboxylic acid transport
ACPL_7100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACPL_7101	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACPL_7102	COG0531	amino acid
ACPL_7103	COG0569	domain protein
ACPL_7108	COG0756	dUTP diphosphatase activity
ACPL_711	COG1937	Protein conserved in bacteria
ACPL_7116	COG5002	protein histidine kinase activity
ACPL_7116	COG5001	Diguanylate cyclase
ACPL_7116	COG3447	MASE1 domain protein
ACPL_7118	COG2860	membrane
ACPL_7120	COG2313	pseudouridylate synthase activity
ACPL_7129	COG0643	Histidine kinase
ACPL_7129	COG2198	Histidine kinase
ACPL_7131	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACPL_7133	COG2201	protein-glutamate methylesterase activity
ACPL_7134	COG0835	chemotaxis
ACPL_7137	COG1490	D-aminoacyl-tRNA deacylase activity
ACPL_7141	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACPL_7146	COG0738	Major facilitator superfamily
ACPL_7149	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACPL_7151	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACPL_7153	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACPL_7155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACPL_7156	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACPL_7157	COG1196	nuclear chromosome segregation
ACPL_7160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACPL_7164	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPL_7166	COG1126	abc transporter atp-binding protein
ACPL_7167	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACPL_7169	COG0765	amino acid transport
ACPL_717	COG0513	Belongs to the DEAD box helicase family
ACPL_7170	COG1418	mRNA catabolic process
ACPL_7171	COG2137	regulation of response to DNA damage stimulus
ACPL_7172	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACPL_7174	COG1573	uracil-dna glycosylase
ACPL_7178	COG2815	serine threonine protein kinase
ACPL_7178	COG0515	serine threonine protein kinase
ACPL_7179	COG1201	RNA secondary structure unwinding
ACPL_7182	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPL_7185	COG1396	sequence-specific DNA binding
ACPL_7186	COG1546	Belongs to the CinA family
ACPL_7186	COG1058	Belongs to the CinA family
ACPL_7188	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACPL_7191	COG1674	ftsk spoiiie
ACPL_7194	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACPL_7195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACPL_7197	COG3214	Protein conserved in bacteria
ACPL_7198	COG0456	acetyltransferase
ACPL_7200	COG1278	Cold shock
ACPL_7202	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACPL_7203	COG0612	Peptidase, M16
ACPL_7204	COG1185	polyribonucleotide nucleotidyltransferase activity
ACPL_7205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACPL_7208	COG0745	RESPONSE REGULATOR receiver
ACPL_7209	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACPL_7211	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACPL_7212	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACPL_7215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACPL_7219	COG0779	Required for maturation of 30S ribosomal subunits
ACPL_7227	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACPL_7228	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACPL_7230	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_7234	COG1668	transmembrane transport
ACPL_7235	COG4152	abc transporter atp-binding protein
ACPL_7236	COG2197	response regulator
ACPL_7237	COG4585	Histidine kinase
ACPL_7241	COG1511	domain protein
ACPL_7242	COG3845	ABC transporter
ACPL_7244	COG0640	Transcriptional regulator
ACPL_7247	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACPL_7248	COG0750	zinc metalloprotease
ACPL_7253	COG2146	nitrite reductase [NAD(P)H] activity
ACPL_7253	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACPL_7256	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACPL_7258	COG0233	cytoplasmic translational termination
ACPL_7259	COG0528	UMP kinase activity
ACPL_7260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACPL_7261	COG0052	Belongs to the universal ribosomal protein uS2 family
ACPL_7262	COG0792	nuclease activity
ACPL_7263	COG0606	chelatase, subunit chli
ACPL_727	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACPL_7273	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACPL_7274	COG0494	nUDIX hydrolase
ACPL_7275	COG0681	Belongs to the peptidase S26 family
ACPL_7276	COG0681	Belongs to the peptidase S26 family
ACPL_7277	COG0335	large ribosomal subunit rRNA binding
ACPL_7278	COG0336	Belongs to the RNA methyltransferase TrmD family
ACPL_7279	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACPL_728	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACPL_7280	COG1837	Belongs to the UPF0109 family
ACPL_7281	COG0228	four-way junction DNA binding
ACPL_7283	COG0442	prolyl-tRNA aminoacylation
ACPL_7290	COG0438	transferase activity, transferring glycosyl groups
ACPL_7293	COG0463	Glycosyl transferase, family 2
ACPL_7295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACPL_7295	COG2755	lipolytic protein G-D-S-L family
ACPL_7298	COG1215	transferase activity, transferring glycosyl groups
ACPL_730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACPL_7301	COG1216	Glycosyl transferase, family 2
ACPL_7302	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACPL_7308	COG2318	DinB family
ACPL_7313	COG0438	transferase activity, transferring glycosyl groups
ACPL_7316	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPL_7318	COG0571	ribonuclease III activity
ACPL_7320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACPL_7323	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACPL_7324	COG0742	ribosomal rna small subunit methyltransferase
ACPL_7328	COG1461	Dihydroxyacetone kinase
ACPL_7329	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACPL_7330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPL_7334	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_7337	COG0626	cystathionine gamma-synthase activity
ACPL_7338	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACPL_7342	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACPL_7345	COG0776	regulation of translation
ACPL_7346	COG0066	3-isopropylmalate dehydratase activity
ACPL_7349	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACPL_7350	COG1476	TRANSCRIPTIONal
ACPL_7352	COG1131	(ABC) transporter
ACPL_7356	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_7357	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACPL_736	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_7361	COG0612	Peptidase, M16
ACPL_7362	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACPL_7365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACPL_7366	COG0473	3-isopropylmalate dehydrogenase activity
ACPL_7370	COG0440	acetolactate synthase activity
ACPL_7372	COG5001	Diguanylate cyclase
ACPL_7372	COG3300	MHYT domain
ACPL_7373	COG0129	dihydroxy-acid dehydratase activity
ACPL_7376	COG2132	Multicopper oxidase
ACPL_7380	COG1609	Transcriptional regulator
ACPL_7381	COG5001	Diguanylate cyclase
ACPL_7383	COG2133	pyrroloquinoline quinone binding
ACPL_7385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACPL_7387	COG0154	amidase activity
ACPL_7388	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACPL_7390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACPL_7392	COG0482	sulfurtransferase activity
ACPL_7394	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACPL_7396	COG2149	membrane
ACPL_740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_7400	COG1595	DNA-templated transcription, initiation
ACPL_7402	COG0443	Heat shock 70 kDa protein
ACPL_7406	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACPL_7407	COG1119	ATPase activity
ACPL_7409	COG1472	Belongs to the glycosyl hydrolase 3 family
ACPL_741	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACPL_7410	COG2902	Dehydrogenase
ACPL_7412	COG0010	Belongs to the arginase family
ACPL_7415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACPL_7417	COG1703	isobutyryl-CoA mutase activity
ACPL_7418	COG0183	Belongs to the thiolase family
ACPL_742	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_7422	COG3046	protein related to deoxyribodipyrimidine photolyase
ACPL_7425	COG4133	protoheme IX ABC transporter activity
ACPL_743	COG0839	Belongs to the complex I subunit 6 family
ACPL_7431	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ACPL_7434	COG1674	ftsk spoiiie
ACPL_7436	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACPL_744	COG0713	ATP synthesis coupled electron transport
ACPL_7443	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACPL_7445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACPL_7446	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACPL_7447	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACPL_7448	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACPL_7449	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACPL_745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACPL_7450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACPL_7451	COG0356	it plays a direct role in the translocation of protons across the membrane
ACPL_7454	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACPL_7455	COG0702	epimerase
ACPL_7456	COG0251	oxidation-reduction process
ACPL_7458	COG0009	L-threonylcarbamoyladenylate synthase
ACPL_746	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_7461	COG2890	protein-(glutamine-N5) methyltransferase activity
ACPL_7462	COG3706	GGDEF domain
ACPL_7464	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACPL_7465	COG0254	rRNA binding
ACPL_7469	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ACPL_747	COG1007	ATP synthesis coupled electron transport
ACPL_7471	COG0083	homoserine kinase activity
ACPL_7473	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACPL_7474	COG1846	Transcriptional regulator
ACPL_7475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACPL_7477	COG0460	homoserine dehydrogenase
ACPL_7479	COG0018	arginyl-trna synthetase
ACPL_748	COG0501	Belongs to the peptidase M48B family
ACPL_7482	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACPL_7486	COG4166	transmembrane transport
ACPL_7487	COG3958	Transketolase
ACPL_7488	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACPL_7489	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACPL_7490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACPL_7493	COG0189	ligase activity
ACPL_7499	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACPL_750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACPL_7501	COG2815	serine threonine protein kinase
ACPL_7501	COG0515	serine threonine protein kinase
ACPL_7505	COG1733	regulation of RNA biosynthetic process
ACPL_7511	COG0673	inositol 2-dehydrogenase activity
ACPL_7515	COG0754	glutathionylspermidine amidase activity
ACPL_7521	COG3469	chitinase activity
ACPL_7524	COG0706	membrane insertase activity
ACPL_7526	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_7529	COG0740	serine-type endopeptidase activity
ACPL_7531	COG1834	amidinotransferase
ACPL_7532	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACPL_7540	COG2205	protein histidine kinase activity
ACPL_7541	COG0745	RESPONSE REGULATOR receiver
ACPL_7545	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACPL_7545	COG0567	Dehydrogenase, E1 component
ACPL_7547	COG0280	phosphate acetyltransferase
ACPL_7547	COG0857	belongs to the CobB CobQ family
ACPL_7548	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACPL_7554	COG2172	sigma factor antagonist activity
ACPL_7555	COG2188	Transcriptional regulator
ACPL_7557	COG1597	lipid kinase activity
ACPL_756	COG1666	GTP binding
ACPL_7560	COG0175	sulfate reduction
ACPL_7564	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACPL_7566	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ACPL_7568	COG1595	DNA-templated transcription, initiation
ACPL_7571	COG2135	peptidase activity
ACPL_7572	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACPL_7573	COG1162	GTPase activity
ACPL_7574	COG0483	inositol monophosphate 1-phosphatase activity
ACPL_758	COG1280	lysine exporter protein (LysE YggA)
ACPL_7588	COG0861	Integral membrane protein TerC family
ACPL_7589	COG1357	PFAM Pentapeptide repeats (8 copies)
ACPL_7596	COG0477	Major facilitator Superfamily
ACPL_7597	COG3800	Transcriptional regulator
ACPL_7597	COG1396	sequence-specific DNA binding
ACPL_7599	COG1615	UPF0182 protein
ACPL_7600	COG3480	Lon protease (S16) C-terminal proteolytic domain
ACPL_7606	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACPL_7614	COG2816	NAD+ diphosphatase activity
ACPL_7617	COG1959	2 iron, 2 sulfur cluster binding
ACPL_7619	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ACPL_762	COG3300	MHYT domain
ACPL_762	COG5001	Diguanylate cyclase
ACPL_7620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACPL_7623	COG1278	Cold shock
ACPL_7626	COG0210	DNA helicase
ACPL_7626	COG0210	DNA helicase
ACPL_7627	COG1611	Belongs to the LOG family
ACPL_7628	COG1611	Belongs to the LOG family
ACPL_763	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACPL_7631	COG2171	N-acyltransferase activity
ACPL_764	COG2030	dehydratase
ACPL_7641	COG4221	oxidoreductase activity
ACPL_7646	COG0456	acetyltransferase
ACPL_7649	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACPL_7650	COG0823	Involved in the tonB-independent uptake of proteins
ACPL_7650	COG1506	peptidase
ACPL_7652	COG0312	modulator of DNA gyrase
ACPL_7654	COG1053	succinate dehydrogenase
ACPL_7660	COG0410	ABC transporter
ACPL_7665	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_7667	COG1960	acyl-CoA dehydrogenase activity
ACPL_7670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACPL_7673	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_768	COG0081	regulation of translation
ACPL_7687	COG0012	GTP binding
ACPL_7690	COG2169	Transcriptional regulator
ACPL_7690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACPL_7694	COG0525	valine-tRNA ligase activity
ACPL_7698	COG1322	Protein conserved in bacteria
ACPL_7699	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACPL_7701	COG1570	exodeoxyribonuclease VII activity
ACPL_7702	COG1722	exodeoxyribonuclease VII activity
ACPL_7708	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACPL_7709	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACPL_7709	COG0561	phosphatase activity
ACPL_771	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACPL_7710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACPL_7711	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACPL_7712	COG1595	DNA-templated transcription, initiation
ACPL_7718	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACPL_772	COG0222	ribosome binding
ACPL_7722	COG2815	serine threonine protein kinase
ACPL_7722	COG0515	serine threonine protein kinase
ACPL_7725	COG1404	Belongs to the peptidase S8 family
ACPL_7726	COG0424	maF-like protein
ACPL_7727	COG4770	biotin carboxylase activity
ACPL_773	COG0085	RNA polymerase activity
ACPL_7737	COG1473	amidohydrolase
ACPL_7737	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACPL_7738	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_7738	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_7739	COG2815	serine threonine protein kinase
ACPL_7739	COG0515	serine threonine protein kinase
ACPL_774	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACPL_7740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACPL_7743	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACPL_7748	COG0438	transferase activity, transferring glycosyl groups
ACPL_7753	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACPL_7755	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_7756	COG1012	belongs to the aldehyde dehydrogenase family
ACPL_7762	COG2018	Roadblock/LC7 domain
ACPL_7764	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACPL_777	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACPL_7777	COG0180	Tryptophanyl-tRNA synthetase
ACPL_7778	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACPL_7779	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACPL_778	COG0049	tRNA binding
ACPL_7784	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACPL_7785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACPL_7786	COG0193	aminoacyl-tRNA hydrolase activity
ACPL_7789	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACPL_779	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACPL_7791	COG1309	transcriptional regulator
ACPL_7793	COG0488	(ABC) transporter
ACPL_7794	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACPL_7795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACPL_7796	COG0084	hydrolase, TatD family'
ACPL_7798	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACPL_780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACPL_7803	COG0726	polysaccharide deacetylase
ACPL_7807	COG4974	Belongs to the 'phage' integrase family
ACPL_781	COG0051	transcription antitermination factor activity, RNA binding
ACPL_7810	COG0303	'Molybdopterin
ACPL_7811	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACPL_7812	COG3706	GGDEF domain
ACPL_7812	COG0745	RESPONSE REGULATOR receiver
ACPL_782	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACPL_7822	COG2095	MarC family integral membrane protein
ACPL_7823	COG0613	PHP domain protein
ACPL_7828	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPL_783	COG0088	Forms part of the polypeptide exit tunnel
ACPL_7836	COG0384	phenazine biosynthesis protein PhzF
ACPL_7837	COG2239	Acts as a magnesium transporter
ACPL_784	COG0089	rRNA binding
ACPL_7840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACPL_7843	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACPL_7846	COG1024	Enoyl-CoA hydratase
ACPL_7848	COG0519	Catalyzes the synthesis of GMP from XMP
ACPL_785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACPL_7851	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACPL_7852	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACPL_7852	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACPL_7853	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACPL_7854	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACPL_786	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACPL_7860	COG0113	porphobilinogen synthase activity
ACPL_7861	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACPL_7861	COG1587	Uroporphyrinogen-III synthase
ACPL_7862	COG0181	hydroxymethylbilane synthase activity
ACPL_7863	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACPL_7864	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ACPL_7867	COG0318	PFAM AMP-dependent synthetase and ligase
ACPL_7868	COG1595	DNA-templated transcription, initiation
ACPL_787	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACPL_7874	COG0506	proline dehydrogenase activity
ACPL_7876	COG1082	Xylose isomerase domain protein TIM barrel
ACPL_788	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACPL_7881	COG0588	phosphoglycerate mutase activity
ACPL_7885	COG0438	transferase activity, transferring glycosyl groups
ACPL_7888	COG0745	RESPONSE REGULATOR receiver
ACPL_789	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACPL_7891	COG5002	protein histidine kinase activity
ACPL_7894	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACPL_7895	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACPL_7897	COG1256	bacterial-type flagellum assembly
ACPL_7897	COG4786	Flagellar basal body rod
ACPL_790	COG0255	Belongs to the universal ribosomal protein uL29 family
ACPL_7901	COG1516	flagellar protein fliS
ACPL_7903	COG1815	bacterial-type flagellum-dependent cell motility
ACPL_7904	COG1558	bacterial-type flagellum-dependent cell motility
ACPL_7905	COG1677	Flagellar hook-basal body complex protein FliE
ACPL_7907	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPL_7909	COG1157	protein secretion by the type III secretion system
ACPL_791	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACPL_7911	COG0739	heme binding
ACPL_7911	COG0741	lytic transglycosylase activity
ACPL_7911	COG1196	nuclear chromosome segregation
ACPL_7915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACPL_7916	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACPL_7918	COG1338	Plays a role in the flagellum-specific transport system
ACPL_792	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACPL_7920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPL_7920	COG1776	CheC inhibitor of MCP methylation
ACPL_7921	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACPL_7923	COG1360	Flagellar Motor Protein
ACPL_7924	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACPL_7929	COG0745	RESPONSE REGULATOR receiver
ACPL_793	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACPL_7933	COG2201	protein-glutamate methylesterase activity
ACPL_7936	COG2198	Histidine kinase
ACPL_7936	COG0643	Histidine kinase
ACPL_7937	COG0745	RESPONSE REGULATOR receiver
ACPL_7938	COG2340	Cysteine-rich secretory protein family
ACPL_7939	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACPL_794	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACPL_795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACPL_7951	COG3246	L-lysine catabolic process to acetate
ACPL_7952	COG0354	folic acid binding
ACPL_7956	COG4044	May play a role in the intracellular transport of hydrophobic ligands
ACPL_796	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACPL_7962	COG1595	DNA-templated transcription, initiation
ACPL_7968	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACPL_7969	COG0581	inorganic phosphate transmembrane transporter activity
ACPL_797	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACPL_7972	COG0456	acetyltransferase
ACPL_7973	COG0745	RESPONSE REGULATOR receiver
ACPL_798	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACPL_7980	COG2339	peptidase activity
ACPL_7986	COG0459	protein refolding
ACPL_7989	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACPL_799	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACPL_7991	COG1131	(ABC) transporter
ACPL_7992	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_7995	COG1131	(ABC) transporter
ACPL_7996	COG1349	DNA-binding transcription factor activity
ACPL_7998	COG1940	carbohydrate kinase activity
ACPL_800	COG1841	ribosomal large subunit assembly
ACPL_8000	COG1131	(ABC) transporter
ACPL_8003	COG2197	response regulator
ACPL_801	COG0200	Binds to the 23S rRNA
ACPL_8014	COG3842	ATPase activity
ACPL_8019	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACPL_8020	COG0215	cysteine-tRNA ligase activity
ACPL_8021	COG1404	Belongs to the peptidase S8 family
ACPL_8022	COG0114	fumarate hydratase activity
ACPL_8023	COG3903	Transcriptional regulator
ACPL_8023	COG3629	intracellular signal transduction
ACPL_8025	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACPL_8025	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACPL_8028	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACPL_803	COG0563	adenylate kinase activity
ACPL_8030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACPL_8032	COG1940	carbohydrate kinase activity
ACPL_8036	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACPL_8037	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACPL_8042	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACPL_8045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACPL_8046	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ACPL_8051	COG1194	a g-specific adenine glycosylase
ACPL_8056	COG0542	response to heat
ACPL_8058	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACPL_8059	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACPL_806	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACPL_8061	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACPL_8063	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACPL_8064	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACPL_8067	COG0649	NAD binding
ACPL_807	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACPL_8070	COG1174	glycine betaine transport
ACPL_8071	COG1174	glycine betaine transport
ACPL_8078	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACPL_808	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACPL_8084	COG1196	nuclear chromosome segregation
ACPL_8084	COG0741	lytic transglycosylase activity
ACPL_8084	COG0739	heme binding
ACPL_8086	COG1674	ftsk spoiiie
ACPL_8089	COG0302	gtp cyclohydrolase
ACPL_809	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACPL_8090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACPL_8092	COG0037	tRNA processing
ACPL_8095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACPL_8097	COG1674	ftsk spoiiie
ACPL_810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACPL_8101	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACPL_8103	COG2843	Capsule synthesis protein
ACPL_8106	COG0439	Biotin carboxylase
ACPL_8114	COG0003	Pfam Anion-transporting ATPase
ACPL_8116	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACPL_8117	COG1610	YqeY-like protein
ACPL_8118	COG1408	metallophosphoesterase
ACPL_812	COG0203	ribosomal protein L17
ACPL_8120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACPL_8124	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_8127	COG4608	Belongs to the ABC transporter superfamily
ACPL_813	COG0101	tRNA pseudouridine synthase activity
ACPL_8130	COG0747	negative chemotaxis
ACPL_8132	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACPL_8137	COG0813	purine-nucleoside phosphorylase activity
ACPL_8138	COG0590	tRNA wobble adenosine to inosine editing
ACPL_8142	COG0287	Prephenate dehydrogenase
ACPL_8143	COG2318	DinB family
ACPL_8144	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACPL_8144	COG0235	Class ii aldolase
ACPL_8145	COG0501	Belongs to the peptidase M48B family
ACPL_8146	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACPL_8146	COG1796	DNA polymerase
ACPL_8149	COG0642	Histidine kinase
ACPL_815	COG2813	Specifically methylates the guanine in position
ACPL_8150	COG2018	Roadblock/LC7 domain
ACPL_816	COG0488	(ABC) transporter
ACPL_8160	COG3979	chitinase
ACPL_8163	COG3706	GGDEF domain
ACPL_8163	COG0745	RESPONSE REGULATOR receiver
ACPL_817	COG0352	thiamine-phosphate diphosphorylase activity
ACPL_8172	COG0778	Nitroreductase
ACPL_8174	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACPL_8178	COG2205	protein histidine kinase activity
ACPL_818	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACPL_818	COG2022	thiamine diphosphate biosynthetic process
ACPL_8182	COG1268	BioY protein
ACPL_8187	COG0667	Aldo Keto reductase
ACPL_8190	COG1131	(ABC) transporter
ACPL_8192	COG1595	DNA-templated transcription, initiation
ACPL_8196	COG0673	inositol 2-dehydrogenase activity
ACPL_8197	COG0243	molybdopterin cofactor binding
ACPL_8199	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACPL_820	COG2022	thiamine diphosphate biosynthetic process
ACPL_8201	COG1435	thymidine kinase activity
ACPL_8203	COG0443	Heat shock 70 kDa protein
ACPL_821	COG0352	thiamine-phosphate diphosphorylase activity
ACPL_8210	COG2268	Band 7 protein
ACPL_8214	COG3979	chitinase
ACPL_8215	COG2199	diguanylate cyclase activity
ACPL_8215	COG2200	EAL domain
ACPL_822	COG0351	phosphomethylpyrimidine kinase
ACPL_8220	COG0148	phosphopyruvate hydratase activity
ACPL_8221	COG0789	Transcriptional regulator
ACPL_8229	COG1366	Belongs to the anti-sigma-factor antagonist family
ACPL_823	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACPL_8231	COG2801	Transposase and inactivated derivatives
ACPL_8232	COG3415	Transposase
ACPL_8232	COG2801	Transposase and inactivated derivatives
ACPL_8234	COG2801	Transposase and inactivated derivatives
ACPL_8253	COG1881	PFAM PEBP family protein
ACPL_8260	COG0789	Transcriptional regulator
ACPL_8261	COG3959	Transketolase, thiamine diphosphate binding domain
ACPL_8262	COG3958	Transketolase
ACPL_8269	COG0598	Magnesium transport protein CorA
ACPL_8270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_8272	COG0371	Dehydrogenase
ACPL_8275	COG0438	transferase activity, transferring glycosyl groups
ACPL_8276	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACPL_8279	COG3275	phosphorelay sensor kinase activity
ACPL_8282	COG2205	protein histidine kinase activity
ACPL_8285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACPL_829	COG2018	Roadblock/LC7 domain
ACPL_8293	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACPL_8306	COG1764	response to oxidative stress
ACPL_8308	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACPL_8309	COG0561	phosphatase activity
ACPL_8310	COG0561	phosphatase activity
ACPL_8312	COG1834	amidinotransferase
ACPL_8313	COG1522	sequence-specific DNA binding
ACPL_8317	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACPL_8321	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACPL_8323	COG1408	metallophosphoesterase
ACPL_8324	COG0210	DNA helicase
ACPL_833	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACPL_8332	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACPL_8332	COG0315	cyclic pyranopterin monophosphate synthase activity
ACPL_8333	COG0315	cyclic pyranopterin monophosphate synthase activity
ACPL_8334	COG5001	Diguanylate cyclase
ACPL_8338	COG0305	Participates in initiation and elongation during chromosome replication
ACPL_834	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACPL_8342	COG0359	binds to the 23S rRNA
ACPL_8343	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACPL_8344	COG0629	single-stranded DNA binding
ACPL_8345	COG0360	Binds together with S18 to 16S ribosomal RNA
ACPL_835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACPL_8350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACPL_8352	COG1695	Transcriptional regulator
ACPL_8353	COG1260	myo-inositol-1-phosphate synthase
ACPL_8365	COG0617	tRNA 3'-terminal CCA addition
ACPL_8368	COG0515	serine threonine protein kinase
ACPL_8368	COG2815	serine threonine protein kinase
ACPL_8369	COG1595	DNA-templated transcription, initiation
ACPL_8372	COG3118	belongs to the thioredoxin family
ACPL_8373	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACPL_8373	COG3409	Peptidoglycan-binding domain 1 protein
ACPL_8375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACPL_8376	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACPL_838	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACPL_8380	COG1192	Involved in chromosome partitioning
ACPL_8381	COG0357	Ribosomal RNA small subunit methyltransferase G
ACPL_8383	COG0706	membrane insertase activity
ACPL_8384	COG0594	ribonuclease P activity
ACPL_8385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACPL_842	COG0736	holo-[acyl-carrier-protein] synthase activity
ACPL_844	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACPL_846	COG0802	atpase or kinase
ACPL_847	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACPL_850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACPL_852	COG1132	(ABC) transporter
ACPL_854	COG0459	protein refolding
ACPL_855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACPL_857	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACPL_858	COG4213	ABC transporter substrate-binding protein
ACPL_860	COG4214	carbohydrate transport
ACPL_867	COG2197	response regulator
ACPL_870	COG0516	GMP reductase activity
ACPL_872	COG1316	TRANSCRIPTIONal
ACPL_873	COG0519	Catalyzes the synthesis of GMP from XMP
ACPL_873	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACPL_874	COG1051	belongs to the nudix hydrolase family
ACPL_876	COG1183	phosphatidylcholine synthase activity
ACPL_877	COG0688	phosphatidylethanolamine metabolic process
ACPL_880	COG4585	Histidine kinase
ACPL_881	COG2197	response regulator
ACPL_882	COG4166	transmembrane transport
ACPL_883	COG0601	transmembrane transport
ACPL_885	COG0444	Belongs to the ABC transporter superfamily
ACPL_886	COG4608	Belongs to the ABC transporter superfamily
ACPL_887	COG1605	Chorismate mutase
ACPL_888	COG4085	toxin activity
ACPL_888	COG0737	Belongs to the 5'-nucleotidase family
ACPL_888	COG1525	nuclease
ACPL_890	COG0739	heme binding
ACPL_892	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACPL_893	COG0045	succinate-CoA ligase (ADP-forming) activity
ACPL_897	COG0138	bifunctional purine biosynthesis protein purh
ACPL_900	COG0538	isocitrate dehydrogenase activity
ACPL_902	COG1349	DNA-binding transcription factor activity
ACPL_905	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACPL_914	COG0489	protein tyrosine kinase activity
ACPL_914	COG3206	protein involved in exopolysaccharide biosynthesis
ACPL_915	COG0529	Catalyzes the synthesis of activated sulfate
ACPL_919	COG1131	(ABC) transporter
ACPL_921	COG0640	Transcriptional regulator
ACPL_922	COG0604	alcohol dehydrogenase
ACPL_923	COG0604	alcohol dehydrogenase
ACPL_923	COG1028	Short-chain dehydrogenase reductase Sdr
ACPL_923	COG3321	synthase
ACPL_925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACPL_926	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACPL_926	COG1024	Enoyl-CoA hydratase
ACPL_933	COG0148	phosphopyruvate hydratase activity
ACPL_936	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACPL_942	COG0714	Associated with various cellular activities
ACPL_948	COG0183	Belongs to the thiolase family
ACPL_953	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACPL_955	COG0456	acetyltransferase
ACPL_956	COG1234	tRNA 3'-trailer cleavage
ACPL_957	COG2326	polyphosphate kinase activity
ACPL_962	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACPL_966	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACPL_967	COG0501	Belongs to the peptidase M48B family
ACPL_968	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACPL_970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACPL_974	COG1331	Highly conserved protein containing a thioredoxin domain
ACPL_976	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACPL_985	COG5001	Diguanylate cyclase
ACPL_989	COG1136	(ABC) transporter
ACPL_989	COG0577	efflux transmembrane transporter activity
ACPL_991	COG3629	intracellular signal transduction
ACPL_991	COG3903	Transcriptional regulator
ACPL_994	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACPL_999	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline