locus-tag class description CDG81_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CDG81_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CDG81_00015 ENOG4108J5G 6-phosphogluconate dehydrogenase CDG81_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CDG81_00025 ENOG4105K7N UPF0232 protein CDG81_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CDG81_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CDG81_00065 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase CDG81_00070 ENOG4108Z6Z Transcriptional regulator CDG81_00115 ENOG4105XBB septation inhibitor protein CDG81_00120 ENOG4108U4N (sortase) family CDG81_00135 ENOG4105CZN Potassium uptake protein CDG81_00145 ENOG4105D9P serine threonine protein kinase CDG81_00150 ENOG4107TPY serine threonine protein kinase CDG81_00155 ENOG4105CJN penicillin-binding protein CDG81_00170 ENOG4105HZM Fha domain containing protein CDG81_00175 ENOG4105TV9 FHA Domain-Containing protein CDG81_00195 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CDG81_00200 ENOG4105EEM helicase CDG81_00205 ENOG4107SWG transcriptional regulator MERR family CDG81_00220 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CDG81_00235 ENOG4107QN2 dihydrolipoyl dehydrogenase CDG81_00245 ENOG4105C37 (CBS) domain CDG81_00260 ENOG4105DJ2 Major Facilitator Superfamily CDG81_00265 ENOG4107258 Transcriptional regulator CDG81_00350 ENOG4108SGK Tetr family transcriptional regulator CDG81_00380 ENOG4105C94 Transporter CDG81_00405 ENOG4107SET aldo keto reductase CDG81_00415 ENOG4105E0Y RtcB Protein CDG81_00445 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CDG81_00450 ENOG4108M1A Chitin-binding protein CDG81_00455 ENOG4105WKW Pfam:DUF1458 CDG81_00475 ENOG4108HRK Histidine kinase CDG81_00485 ENOG4108NEV two component transcriptional regulator, LytTR family CDG81_00495 ENOG4107QN1 sodium solute CDG81_00500 ENOG41085GJ domain protein CDG81_00515 ENOG4107YEV ferritin CDG81_00525 ENOG4105U0R haloacid dehalogenase-like hydrolase CDG81_00530 ENOG4105IE8 Alpha-ketoglutarate permease CDG81_00540 ENOG4105CMT Dihydroxyacetone kinase CDG81_00545 ENOG4107YVI ribose 5-phosphate isomerase CDG81_00565 ENOG4108VGI doxx family CDG81_00620 ENOG4105CEU Arginine dihydrolase CDG81_00655 ENOG4105C4M (Ubiquinol oxidase) subunit I CDG81_00660 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CDG81_00665 ENOG4108JJ9 ABC, transporter CDG81_00685 ENOG4108UVJ appr-1-p processing domain protein CDG81_00705 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CDG81_00715 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CDG81_00720 ENOG410667J hydrolase CDG81_00735 ENOG410602S Transferase CDG81_00745 ENOG4106YN8 Prenyltransferase CDG81_00750 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CDG81_00775 ENOG4107YB1 Trehalose corynomycolyl transferase CDG81_00805 ENOG4105J1Z Arabinosyltransferase CDG81_00810 ENOG4108MKI Glycosyl transferase, family 2 CDG81_00835 ENOG4105IIU Aminopeptidase CDG81_00845 ENOG4105CJ1 ABC, transporter CDG81_00865 ENOG4105CIH Imidazole acetol-phosphate transaminase CDG81_00875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CDG81_00890 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CDG81_00960 ENOG4105CHU acetyl-coa acetyltransferase CDG81_00965 ENOG4105EVN Prephenate dehydrogenase CDG81_00975 ENOG4108Z6B deaminase CDG81_00980 ENOG4108J08 Csbd family CDG81_01015 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CDG81_01020 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CDG81_01035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CDG81_01040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDG81_01045 ENOG4105C3U ABC transporter CDG81_01050 ENOG4108JQ7 (ABC) transporter CDG81_01090 ENOG4105CFH Aspartokinase CDG81_01110 ENOG4105C6Z Gluconate CDG81_01130 ENOG4105CH6 catalase CDG81_01135 ENOG4108VJY integral membrane protein CDG81_01160 ENOG4108S01 response regulator CDG81_01170 ENOG4107YFT Nadph-dependent fmn reductase CDG81_01195 ENOG4105CJ1 ABC, transporter CDG81_01205 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CDG81_01220 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CDG81_01225 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CDG81_01240 ENOG4105P8F nudix hydrolase CDG81_01245 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CDG81_01270 ENOG4105VN1 Heat shock protein CDG81_01275 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CDG81_01320 ENOG4108JQC penicillin-binding protein 1A CDG81_01325 ENOG4105Q26 Siderophore-interacting protein CDG81_01335 ENOG4107RGJ metallophosphoesterase CDG81_01350 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CDG81_01370 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CDG81_01375 ENOG4106KNT transcriptional regulator CDG81_01390 ENOG4107QK9 Beta-lactamase CDG81_01395 ENOG4105EHZ conserved protein UCP016719 CDG81_01400 ENOG4105D17 glycoside hydrolase, family 3 domain protein CDG81_01465 ENOG4108I5C dEAD DEAH box helicase CDG81_01470 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for CDG81_01480 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CDG81_01485 ENOG4107QRG dna polymerase iii CDG81_01530 ENOG4105F0N pyrophosphate phospho-hydrolase CDG81_01545 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CDG81_01555 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CDG81_01560 ENOG4105EUJ GTP cyclohydrolase i CDG81_01600 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CDG81_01605 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CDG81_01610 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CDG81_01615 ENOG4105CRK lysyL-tRNA synthetase CDG81_01635 ENOG4105DQ5 transport system permease protein CDG81_01640 ENOG4105TVJ transport system, permease CDG81_01645 ENOG4105E0A ABC, transporter CDG81_01650 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CDG81_01685 ENOG4105C8P )-transporter CDG81_01715 ENOG4105ECB domain protein CDG81_01720 ENOG4105FDK ABC transporter CDG81_01725 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CDG81_01740 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CDG81_01755 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CDG81_01765 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CDG81_01770 ENOG4105C8N cysteinyl-tRNA synthetase CDG81_01780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CDG81_01790 ENOG4105CC5 ABC transporter CDG81_01795 ENOG4105E0A ABC, transporter CDG81_01825 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CDG81_01855 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase CDG81_01885 ENOG4105CDU Replicative dna helicase CDG81_01895 ENOG4105BZU Histidine kinase CDG81_02000 ENOG41060M0 Crispr-associated protein, cse4 family CDG81_02075 ENOG4105EUB pirin domain protein CDG81_02090 ENOG4105CPQ Dehydrogenase CDG81_02110 ENOG4105C7B Threonine dehydratase CDG81_02115 ENOG4107S2E monooxygenase CDG81_02190 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase CDG81_02200 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) CDG81_02240 ENOG4105RD7 BadF BadG BcrA BcrD CDG81_02245 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CDG81_02250 ENOG4105FDP GntR family transcriptional regulator CDG81_02265 ENOG4106T9R serine protease CDG81_02270 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CDG81_02275 ENOG4105MWK D-amino acid dehydrogenase, small subunit CDG81_02285 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CDG81_02290 ENOG4105VT3 DNA binding domain protein, excisionase family CDG81_02325 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CDG81_02335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CDG81_02365 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme CDG81_02385 ENOG4105VEQ Cold shock protein CDG81_02395 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CDG81_02400 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 CDG81_02420 ENOG4105VEQ Cold shock protein CDG81_02460 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CDG81_02465 ENOG4105VT3 DNA binding domain protein, excisionase family CDG81_02505 ENOG4107TCW O-succinylbenzoate synthase CDG81_02515 ENOG4105CFI type iii restriction protein res subunit CDG81_02530 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CDG81_02550 ENOG4105GWZ Roadblock lc7 family protein CDG81_02580 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CDG81_02595 ENOG4105MS9 Resuscitation-promoting factor CDG81_02605 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CDG81_02610 ENOG4105F4R Transcriptional regulator mode CDG81_02635 ENOG410901E Membrane CDG81_02640 ENOG4107TIF Phenazine biosynthesis protein, PhzF family CDG81_02680 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_02705 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta CDG81_02755 ENOG4107Y80 Major Facilitator superfamily CDG81_02770 ENOG4105C2C drug resistance transporter, Bcr CflA CDG81_02775 ENOG4105FCS tRNA rRNA methyltransferase CDG81_02800 ENOG4105EB3 Histidine kinase CDG81_02805 ENOG4108KXV response regulator CDG81_02815 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CDG81_02835 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CDG81_02865 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CDG81_02870 ENOG4107WI4 Aldose-1-epimerase CDG81_02875 ENOG4105C1G acyl-Coa dehydrogenase CDG81_02885 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CDG81_02895 ENOG4105RHA ABC transporter, permease CDG81_02900 ENOG4108IUX (ABC) transporter CDG81_02910 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CDG81_02920 ENOG4105EC2 ftsk spoIIIe CDG81_02945 ENOG4105E5G Alpha beta hydrolase fold CDG81_02960 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CDG81_02965 ENOG4108J2P Alpha beta hydrolase fold CDG81_02970 ENOG4105E2K Glycosyl transferase (Group 1 CDG81_02980 ENOG4105CPC Aldo Keto reductase CDG81_02985 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CDG81_02995 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_03000 ENOG4105BZU Histidine kinase CDG81_03005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDG81_03010 ENOG4105EDW glycosyl transferase, family 39 CDG81_03010 ENOG4105EDW glycosyl transferase, family 39 CDG81_03035 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin CDG81_03040 ENOG4107SM8 Adenylate Guanylate cyclase CDG81_03065 ENOG4105XTG Pfam:DUF156 CDG81_03150 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CDG81_03155 ENOG4105CPC Aldo Keto reductase CDG81_03160 ENOG4105K56 Transcriptional regulator CDG81_03165 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CDG81_03190 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold CDG81_03235 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_03260 ENOG4105CKD glutathione-regulated potassium-efflux system protein CDG81_03310 ENOG4105CXN decarboxylase CDG81_03320 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase CDG81_03365 ENOG4107R08 Integrase CDG81_03395 ENOG4105BZU Histidine kinase CDG81_03400 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase CDG81_03405 ENOG4105ETX regulatoR CDG81_03415 ENOG4105E98 transcriptional regulator DeoR family CDG81_03430 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CDG81_03450 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase CDG81_03455 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CDG81_03465 ENOG4105D9U N-acetyltransferase CDG81_03480 ENOG4105CH6 catalase CDG81_03500 ENOG4107R11 Transcriptional regulator CDG81_03510 ENOG4108UHU Aldolase CDG81_03515 ENOG4105D7K pfkb domain protein CDG81_03520 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CDG81_03525 ENOG4107EJG GntR family transcriptional regulator CDG81_03530 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CDG81_03535 ENOG4105CXK mandelate racemase muconate lactonizing CDG81_03540 ENOG4107R72 Ceramidase CDG81_03550 ENOG4108S01 response regulator CDG81_03560 ENOG4105CJ1 ABC, transporter CDG81_03580 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CDG81_03595 ENOG4105EPH radical SAM domain protein CDG81_03615 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CDG81_03630 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CDG81_03640 ENOG4107TPY serine threonine protein kinase CDG81_03645 ENOG4105D65 subunit l CDG81_03655 ENOG4105MKQ Monovalent cation H antiporter subunit C CDG81_03660 ENOG4108JPZ Monovalent cation H antiporter subunit D CDG81_03680 ENOG4105C94 Transporter CDG81_03695 ENOG4107RM1 amidohydrolase CDG81_03715 ENOG4105CUT histidyl-tRNA synthetase CDG81_03750 ENOG4105CGZ zinc metallopeptidase CDG81_03755 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CDG81_03760 ENOG4105CRQ synthase (Component I) CDG81_03765 ENOG4107WR6 Maf-like protein CDG81_03770 ENOG4107QJT sodium dicarboxylate symporter CDG81_03775 ENOG4108JIK carboxylase CDG81_03805 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CDG81_03810 ENOG4105E98 transcriptional regulator DeoR family CDG81_03815 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CDG81_03820 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CDG81_03825 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CDG81_03840 ENOG4105D8K carboxyl transferase CDG81_03855 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CDG81_03890 ENOG4108UW5 maltose o-acetyltransferase CDG81_03895 ENOG4108RFG Tetr family transcriptional regulator CDG81_03955 ENOG4107TK4 histidinol-phosphate phosphatase CDG81_03960 ENOG4105ETX regulatoR CDG81_03965 ENOG41065SU Two-component system sensor kinase CDG81_03980 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CDG81_03990 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) CDG81_04075 ENOG4107TB5 TRANSCRIPTIONal CDG81_04080 ENOG4107TB5 TRANSCRIPTIONal CDG81_04100 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CDG81_04105 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CDG81_04135 ENOG4105E2K Glycosyl transferase (Group 1 CDG81_04155 ENOG4107V9E glucose-1-phosphate thymidylyltransferase CDG81_04205 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) CDG81_04215 ENOG4105E1F short-chain dehydrogenase reductase CDG81_04220 ENOG4107XZ0 Peptidase M50 CDG81_04225 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CDG81_04260 ENOG4105EIP mannose-6-phosphate isomerase CDG81_04265 ENOG4105CUB amino acid CDG81_04280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDG81_04285 ENOG4105BZU Histidine kinase CDG81_04290 ENOG4108MKR lipoprotein lpqb CDG81_04300 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea CDG81_04305 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CDG81_04335 ENOG4105C2N RNA methyltransferase TrmH family group 3 CDG81_04360 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CDG81_04365 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CDG81_04390 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CDG81_04405 ENOG4107TE5 Lipid kinase CDG81_04445 ENOG4108VEQ Superoxide dismutase CDG81_04455 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CDG81_04460 ENOG4105C6K Malic enzyme CDG81_04475 ENOG4108IJ8 ABC transporter CDG81_04480 ENOG4105E90 ABC transporter CDG81_04485 ENOG4105E90 ABC transporter CDG81_04515 ENOG4105C84 Histidine ammonia-lyase CDG81_04520 ENOG4105CGP Urocanate hydratase CDG81_04530 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CDG81_04535 ENOG4105CI2 imidazolone-5-propionate hydrolase CDG81_04555 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CDG81_04560 ENOG4105CPQ Dehydrogenase CDG81_04580 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CDG81_04590 ENOG4105BZ1 (ABC) transporter CDG81_04600 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CDG81_04690 ENOG4105XYF acetyltransferase CDG81_04735 ENOG41087EV Hsp20/alpha crystallin family CDG81_04760 ENOG4105DCF alanine dehydrogenase CDG81_04765 ENOG4108K8K Transcriptional regulator CDG81_04770 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CDG81_04775 ENOG4105EJQ L-serine dehydratase CDG81_04785 ENOG4108Z4X TRANSCRIPTIONal CDG81_04790 ENOG410846T CoA-transferase family III CDG81_04835 ENOG4105CQB FAD linked oxidase domain protein CDG81_04840 ENOG4105CQB FAD linked oxidase domain protein CDG81_04845 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CDG81_04855 ENOG4105CHU acetyl-coa acetyltransferase CDG81_04860 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CDG81_04880 ENOG4107RN6 Monooxygenase CDG81_04900 ENOG4105BZ4 penicillin-binding protein CDG81_04940 ENOG4105CXK mandelate racemase muconate lactonizing CDG81_04975 ENOG4108YZ9 Urea amidohydrolase subunit gamma CDG81_04980 ENOG4105KI2 Urea amidohydrolase subunit beta CDG81_04985 ENOG4105CQM Urea amidohydrolase subunit alpha CDG81_04995 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CDG81_05000 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CDG81_05015 ENOG4108JQ5 ABC transporter CDG81_05020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDG81_05030 ENOG4108J59 Extracellular solute-binding protein, family 5 CDG81_05040 ENOG410880H cysteine synthase CDG81_05065 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDG81_05085 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) CDG81_05100 ENOG4105C75 arginyL-tRNA synthetase CDG81_05105 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CDG81_05110 ENOG4105D6E homoserine dehydrogenase CDG81_05115 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CDG81_05120 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CDG81_05125 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CDG81_05130 ENOG4105VFB Binds the 23S rRNA (By similarity) CDG81_05135 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CDG81_05140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CDG81_05145 ENOG4107UB2 Alpha beta hydrolase fold CDG81_05155 ENOG4105ESV Glycosyl transferase, family 4 CDG81_05165 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) CDG81_05175 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CDG81_05180 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CDG81_05185 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CDG81_05190 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CDG81_05195 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CDG81_05200 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CDG81_05220 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CDG81_05250 ENOG4105N14 lysine exporter protein LysE YggA CDG81_05290 ENOG4105CMT Dihydroxyacetone kinase CDG81_05295 ENOG4108UTZ Dihydroxyacetone kinase CDG81_05300 ENOG4105VDH Dihydroxyacetone kinase CDG81_05325 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CDG81_05340 ENOG4108IG5 Transcriptional regulator CDG81_05350 ENOG4105CHU acetyl-coa acetyltransferase CDG81_05370 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CDG81_05400 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CDG81_05405 ENOG4105DKW ABC transporter CDG81_05420 ENOG4105CQ7 ATP-dependent helicase CDG81_05425 ENOG4105EPR degv family CDG81_05435 ENOG4105C10 Electron transfer flavoprotein CDG81_05445 ENOG4108Z20 Acyl-transferase CDG81_05460 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CDG81_05475 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CDG81_05500 ENOG4105DWF phosphomethylpyrimidine kinase CDG81_05505 ENOG4105ETU transcriptional activator (TenA CDG81_05545 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CDG81_05560 ENOG4107HP6 Transcriptional regulator CDG81_05565 ENOG4105CP7 Triose-phosphate isomerase CDG81_05575 ENOG4108VA3 3-hexulose-6-phosphate synthase CDG81_05580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDG81_05585 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDG81_05610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CDG81_05615 ENOG4108MRH transcriptional regulatory protein CDG81_05620 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CDG81_05675 ENOG4105C7I Dehydrogenase CDG81_05680 ENOG4108TGP Thioesterase superfamily protein CDG81_05690 ENOG4105CG3 alpha amylase, catalytic region CDG81_05695 ENOG4105CG3 alpha amylase, catalytic region CDG81_05705 ENOG4105D8X mechanosensitive ion channel CDG81_05745 ENOG4105MC2 DSBA oxidoreductase CDG81_05770 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDG81_05790 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CDG81_05795 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CDG81_05800 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CDG81_05805 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CDG81_05815 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CDG81_05820 ENOG4105F0V Cell wall hydrolase CDG81_05855 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CDG81_05860 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CDG81_05870 ENOG4107QPD alcohol dehydrogenase CDG81_05875 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CDG81_05885 ENOG4105CCT upf0313 protein CDG81_05895 ENOG4105C03 ribonuclease CDG81_05895 ENOG4105C03 ribonuclease CDG81_05915 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CDG81_05920 ENOG4105K46 50S ribosomal protein l27 CDG81_05925 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CDG81_05930 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CDG81_05935 ENOG4105C9U ATP-dependent DNA helicase RecQ CDG81_05955 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CDG81_05970 ENOG4105EPR degv family CDG81_05995 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CDG81_06020 ENOG4105VT3 DNA binding domain protein, excisionase family CDG81_06035 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CDG81_06060 ENOG4105C26 Dehydrogenase CDG81_06065 ENOG4105C1G acyl-Coa dehydrogenase CDG81_06070 ENOG4105E39 Enoyl-CoA hydratase CDG81_06075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CDG81_06085 ENOG41067XF inhibitor CDG81_06100 ENOG4105CHP RNA polymerase CDG81_06165 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CDG81_06175 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CDG81_06180 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CDG81_06190 ENOG4105K59 histidine triad (HIT) protein CDG81_06200 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CDG81_06215 ENOG4105XMC MarR family Transcriptional regulator CDG81_06225 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CDG81_06240 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CDG81_06250 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CDG81_06270 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CDG81_06310 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CDG81_06380 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CDG81_06400 ENOG4107QN2 dihydrolipoyl dehydrogenase CDG81_06420 ENOG4105BZU Histidine kinase CDG81_06425 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_06450 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CDG81_06475 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CDG81_06545 ENOG4105EG6 Saccharopine dehydrogenase CDG81_06555 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CDG81_06580 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CDG81_06605 ENOG4105EGD dinuclear metal center protein, YbgI family CDG81_06615 ENOG4105CVJ phosphoglycerate mutase CDG81_06620 ENOG4105E2R ROK family CDG81_06680 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CDG81_06690 ENOG4105CHF Glutathione S-transferase CDG81_06695 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CDG81_06700 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CDG81_06730 ENOG4105C4K Nad synthetase CDG81_06740 ENOG4105C5F glutamine synthetase CDG81_06770 ENOG4105RNG membrane CDG81_06775 ENOG4105K6V RNA polymerase CDG81_06805 ENOG4107UBC ErfK ybiS ycfS ynhG family protein CDG81_06820 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CDG81_06835 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CDG81_06840 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CDG81_06850 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CDG81_06865 ENOG4105C01 Dihydroxy-acid dehydratase CDG81_06880 ENOG4108ZP8 Acetolactate synthase small subunit CDG81_06885 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CDG81_06895 ENOG4108JQ1 Dehydrogenase CDG81_06900 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CDG81_06905 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CDG81_06910 ENOG4105ERH Fumarylacetoacetate hydrolase CDG81_06920 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CDG81_06950 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CDG81_06955 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CDG81_06975 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) CDG81_06985 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CDG81_06990 ENOG4105C28 cystathionine CDG81_07005 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CDG81_07010 ENOG4105CPF Cell wall formation (By similarity) CDG81_07030 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CDG81_07035 ENOG4105VB9 50S ribosomal protein l28 CDG81_07040 ENOG4105DP4 dak2 domain fusion protein ylov CDG81_07050 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CDG81_07055 ENOG4106H78 methyltransferase CDG81_07060 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CDG81_07085 ENOG41084BZ 50S ribosomal protein L32 CDG81_07090 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CDG81_07095 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CDG81_07100 ENOG4105CAQ asparagine synthetase CDG81_07105 ENOG4107Z1W Fructose transport system kinase CDG81_07115 ENOG4108375 Acylphosphatase (EC 3.6.1.7) CDG81_07120 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CDG81_07125 ENOG4105CK7 Sodium proline symporter CDG81_07130 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CDG81_07150 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) CDG81_07180 ENOG4105K5M 30s ribosomal protein S16 CDG81_07190 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CDG81_07195 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CDG81_07200 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CDG81_07205 ENOG4107QYR Signal peptidase i CDG81_07210 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CDG81_07220 ENOG41080R2 UPF0102 protein CDG81_07225 ENOG4105C0P Mg chelatase subunit ChlI CDG81_07240 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDG81_07250 ENOG4105CE9 30S ribosomal protein S2 CDG81_07255 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CDG81_07260 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CDG81_07265 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CDG81_07270 ENOG4105KNE Phosphatidate cytidylyltransferase CDG81_07290 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CDG81_07295 ENOG41068X0 Protein of unknown function (DUF2631) CDG81_07300 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CDG81_07305 ENOG4105DZP Membrane-associated zinc metalloprotease CDG81_07310 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CDG81_07320 ENOG4105CJN penicillin-binding protein CDG81_07335 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CDG81_07340 ENOG4105JXH GntR family transcriptional regulator CDG81_07345 ENOG4105DJ2 Major Facilitator Superfamily CDG81_07390 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CDG81_07395 ENOG4105CHR reductase CDG81_07410 ENOG4108M26 parallel beta-helix repeat protein CDG81_07440 ENOG4108V1U phospholipid-binding protein CDG81_07445 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap CDG81_07450 ENOG4105N14 lysine exporter protein LysE YggA CDG81_07455 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap CDG81_07475 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CDG81_07510 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CDG81_07515 ENOG4105CTK cobaltochelatase, cobn subunit CDG81_07520 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CDG81_07525 ENOG41081F0 Precorrin-8x methylmutase CDG81_07540 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CDG81_07550 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase CDG81_07555 ENOG4107XFJ UPF0246 protein CDG81_07565 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CDG81_07575 ENOG4107ZED Uncharacterised protein family UPF0047 CDG81_07600 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) CDG81_07615 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CDG81_07620 ENOG4105W7A Protein of unknown function (DUF503) CDG81_07625 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CDG81_07640 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CDG81_07645 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CDG81_07665 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CDG81_07670 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CDG81_07710 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) CDG81_07720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CDG81_07725 ENOG4105CN5 Metallo-Beta-Lactamase CDG81_07735 ENOG4106JDR secreted CDG81_07760 ENOG4105CEV competence damage-inducible protein CDG81_07765 ENOG4105WBV Transcriptional regulator CDG81_07780 ENOG4105C2W permease CDG81_07785 ENOG4107SKI cobyrinic Acid a,c-diamide synthase CDG81_07790 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CDG81_07810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CDG81_07815 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CDG81_07840 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CDG81_07845 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CDG81_07860 ENOG4105DFU Cell wall formation (By similarity) CDG81_07890 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CDG81_07910 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CDG81_07915 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CDG81_07935 ENOG4105C0B DNA polymerase III (alpha subunit) CDG81_07940 ENOG4106A3M Cytochrome p-450 CDG81_07970 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CDG81_08010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDG81_08020 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) CDG81_08030 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CDG81_08035 ENOG4105CIH Imidazole acetol-phosphate transaminase CDG81_08040 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CDG81_08045 ENOG4105C6T cysteine synthase CDG81_08055 ENOG4108Z4X TRANSCRIPTIONal CDG81_08060 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CDG81_08070 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CDG81_08075 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CDG81_08080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CDG81_08090 ENOG4105CRQ synthase (Component I) CDG81_08100 ENOG4105DK0 Indole-3-glycerol phosphate synthase CDG81_08105 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CDG81_08110 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CDG81_08115 ENOG4107V6M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CDG81_08120 ENOG4105E0A ABC, transporter CDG81_08125 ENOG4105DQ5 transport system permease protein CDG81_08130 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CDG81_08140 ENOG4107EJG GntR family transcriptional regulator CDG81_08160 ENOG4105C29 acyl-CoA thioesterase CDG81_08175 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CDG81_08180 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CDG81_08185 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CDG81_08190 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CDG81_08195 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CDG81_08205 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_08215 ENOG4105C1G acyl-Coa dehydrogenase CDG81_08220 ENOG4105EQN UPF0261 protein CDG81_08235 ENOG4105CMR udp-glucose 4-epimerase CDG81_08280 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CDG81_08285 ENOG4108PVQ transcriptional regulator CDG81_08295 ENOG4107QN2 dihydrolipoyl dehydrogenase CDG81_08300 ENOG4108JYK Dehydrogenase CDG81_08305 ENOG4105CPP Dehydrogenase, E1 component CDG81_08330 ENOG4105BZU Histidine kinase CDG81_08390 ENOG410849S phosphocarrier protein (HPr) CDG81_08395 ENOG4105DM4 PTS System CDG81_08405 ENOG4105DE4 1-phosphofructokinase CDG81_08420 ENOG4108ZHJ Organic hydroperoxide resistance protein CDG81_08425 ENOG41066UM arsR family transcriptional regulator CDG81_08430 ENOG4105CKU formyltetrahydrofolate synthetase CDG81_08440 ENOG4107TNW (Aminomethyl transferase) family protein CDG81_08460 ENOG4105WIU sarcosine oxidase delta subunit CDG81_08475 ENOG4105J4Q Transcriptional regulator CDG81_08490 ENOG4107HP6 Transcriptional regulator CDG81_08500 ENOG4108Z0R Transferase CDG81_08505 ENOG4107YPT transcriptional regulator CDG81_08515 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_08530 ENOG4105C1G acyl-Coa dehydrogenase CDG81_08540 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CDG81_08555 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CDG81_08580 ENOG4105CH2 amidohydrolase CDG81_08590 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CDG81_08655 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) CDG81_08665 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase CDG81_08685 ENOG4105DMQ Methyltransferase CDG81_08690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CDG81_08715 ENOG4105C1G acyl-Coa dehydrogenase CDG81_08720 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) CDG81_08730 ENOG4106YT9 Enoyl-CoA hydratase CDG81_08740 ENOG4108W5M transcriptional regulator CDG81_08755 ENOG4105CIG ABC transporter CDG81_08760 ENOG4105DU1 integral membrane protein, terc CDG81_08780 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_08785 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CDG81_08800 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CDG81_08820 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 CDG81_08835 ENOG4105C26 Dehydrogenase CDG81_08840 ENOG4108RFG Tetr family transcriptional regulator CDG81_08860 ENOG4107YXZ hydrolase, family 25 CDG81_08865 ENOG4105E2K Glycosyl transferase (Group 1 CDG81_08870 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CDG81_08890 ENOG4107RCI amp-dependent synthetase and ligase CDG81_08900 ENOG4105D8K carboxyl transferase CDG81_08915 ENOG41082W1 Cupin 2, conserved barrel domain protein CDG81_08950 ENOG4105C8Y Acetylornithine aminotransferase CDG81_08965 ENOG4108RZE Tetr family transcriptional regulator CDG81_08970 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CDG81_08975 ENOG4105DQU oxidoreductase, subunit beta CDG81_08985 ENOG4107QQG Dehydrogenase CDG81_08995 ENOG4105C3M thioredoxin reductase CDG81_09000 ENOG4105D3Q Sugar transferase CDG81_09005 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CDG81_09015 ENOG4105VRS hydrolase family 18 CDG81_09025 ENOG4108S01 response regulator CDG81_09030 ENOG4107T8Q Glycosyl transferase (Group 1 CDG81_09040 ENOG4107WI4 Aldose-1-epimerase CDG81_09045 ENOG4105CNT hydrolase family 2 CDG81_09055 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CDG81_09070 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CDG81_09135 ENOG4108UKI Enoyl-CoA hydratase CDG81_09140 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) CDG81_09155 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_09160 ENOG4105E2D ec 3.2.1.52 CDG81_09180 ENOG4108UW8 fha domain-containing protein CDG81_09195 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CDG81_09225 ENOG4105DUX Transporter CDG81_09250 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process CDG81_09260 ENOG41067HS methyltransferase CDG81_09275 ENOG4107QM5 aconitate hydratase CDG81_09280 ENOG4105E2A Dehydrogenase CDG81_09295 ENOG4105EGE secreted protein CDG81_09310 ENOG4107QZF nitrite reductase NADPH large subunit CDG81_09315 ENOG4107QZF nitrite reductase NADPH large subunit CDG81_09320 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CDG81_09325 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CDG81_09330 ENOG4105ZXU NLP P60 protein CDG81_09340 ENOG4105CS1 NAD(P)H quinone oxidoreductase CDG81_09345 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CDG81_09350 ENOG4105FBA Phospholipase Carboxylesterase CDG81_09360 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) CDG81_09375 ENOG4105CHU acetyl-coa acetyltransferase CDG81_09390 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CDG81_09395 ENOG4105F2Z 3-oxoadipate enol-lactonase CDG81_09400 ENOG4107HP6 Transcriptional regulator CDG81_09405 ENOG4105BZ1 (ABC) transporter CDG81_09410 ENOG4105BZM domain protein CDG81_09415 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CDG81_09445 ENOG4105EWU Squalene--hopene cyclase CDG81_09465 ENOG4108W6C Dehydrogenase CDG81_09470 ENOG4105PP6 Membrane CDG81_09480 ENOG4108Z4U Ferredoxin CDG81_09485 ENOG4105MVE transcriptional regulator CDG81_09510 ENOG4108YV4 Universal stress protein CDG81_09525 ENOG4105CVN desaturase CDG81_09535 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CDG81_09715 ENOG4107VC8 ATP cone domain protein CDG81_09725 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) CDG81_09730 ENOG4105C2M dna polymerase I CDG81_09735 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CDG81_09755 ENOG4105DTD Dehydrogenase CDG81_09765 ENOG4105D22 carbon starvation protein CDG81_09780 ENOG4105C5X domain protein CDG81_09795 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CDG81_09800 ENOG4105DJ2 Major Facilitator Superfamily CDG81_09805 ENOG4105E2D ec 3.2.1.52 CDG81_09825 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CDG81_09840 ENOG4107258 Transcriptional regulator CDG81_09845 ENOG4105KME endoribonuclease L-psp CDG81_09865 ENOG41084BS 50S ribosomal protein L35 CDG81_09870 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CDG81_09875 ENOG4108RWN rrna methyltransferase CDG81_09880 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CDG81_09885 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CDG81_09890 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CDG81_09895 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CDG81_09900 ENOG4105CAS nag kinase CDG81_09910 ENOG4105DBV ornithine carbamoyltransferase CDG81_09920 ENOG4105CDH Citrulline--aspartate ligase CDG81_09925 ENOG4105CH7 arginosuccinase CDG81_09930 ENOG4108VX5 3-methyladenine DNA glycosylase CDG81_09935 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CDG81_09960 ENOG4105DSU hydrolase CDG81_09975 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CDG81_10000 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CDG81_10020 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CDG81_10025 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CDG81_10035 ENOG4107S91 Sodium hydrogen exchanger CDG81_10045 ENOG4105CAT Cytidine monophosphate kinase CDG81_10050 ENOG4105E9Q Acyl-transferase CDG81_10055 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CDG81_10060 ENOG4105CV8 reductase CDG81_10080 ENOG4105VF7 tolerance protein CDG81_10090 ENOG41090A4 Pterin carbinolamine dehydratase CDG81_10115 ENOG4105CBC glutamate synthase CDG81_10125 ENOG4106T9R serine protease CDG81_10135 ENOG410635A Membrane CDG81_10140 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CDG81_10145 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CDG81_10160 ENOG4105KT7 mgtC SapB transporter CDG81_10165 ENOG4105CQB FAD linked oxidase domain protein CDG81_10175 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CDG81_10180 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CDG81_10225 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CDG81_10230 ENOG4105DU1 integral membrane protein, terc CDG81_10245 ENOG41061GT Aldolase CDG81_10265 ENOG41073TP transcriptional regulator CDG81_10275 ENOG4108KGH TRANSCRIPTIONal CDG81_10320 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CDG81_10325 ENOG41084GC stage II sporulation protein CDG81_10355 ENOG4105C57 major facilitator superfamily CDG81_10365 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CDG81_10390 ENOG4105CQ7 ATP-dependent helicase CDG81_10495 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CDG81_10515 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CDG81_10520 ENOG4105ETE Transcriptional regulator (LacI family CDG81_10530 ENOG41082SX arsR family transcriptional regulator CDG81_10560 ENOG4105ENX hydrolase CDG81_10585 ENOG4108Z7R Chaperone CsaA CDG81_10630 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CDG81_10720 ENOG4108IG5 Transcriptional regulator CDG81_10730 ENOG41087PP glycosyltransferase MGT family CDG81_10740 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CDG81_10770 ENOG4105CVJ phosphoglycerate mutase CDG81_10775 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CDG81_10780 ENOG4105CPC Aldo Keto reductase CDG81_10785 ENOG4105DXI Major Facilitator superfamily CDG81_10795 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CDG81_10820 ENOG4105CIG ABC transporter CDG81_10825 ENOG4105DIM ABC transporter CDG81_10855 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_10920 ENOG4105C2C drug resistance transporter, Bcr CflA CDG81_10925 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CDG81_10930 ENOG4105DMS mur ligase CDG81_10950 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CDG81_10960 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CDG81_10965 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CDG81_10970 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CDG81_11015 ENOG4105C57 major facilitator superfamily CDG81_11025 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) CDG81_11040 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CDG81_11045 ENOG4105EM7 Selenocysteine-specific translation elongation factor CDG81_11050 ENOG4105FDF Could be involved in DNA repair (By similarity) CDG81_11055 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CDG81_11080 ENOG4105CGD Nad-dependent epimerase dehydratase CDG81_11095 ENOG4105VEQ Cold shock protein CDG81_11145 ENOG4108YV4 Universal stress protein CDG81_11155 ENOG4108YV4 Universal stress protein CDG81_11160 ENOG4108YV4 Universal stress protein CDG81_11165 ENOG4108YV4 Universal stress protein CDG81_11185 ENOG4105DMF Dehydrogenase CDG81_11190 ENOG4105C2C drug resistance transporter, Bcr CflA CDG81_11195 ENOG4108VHC Short-chain dehydrogenase reductase Sdr CDG81_11235 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CDG81_11245 ENOG4105C0W non-ribosomal peptide synthetase CDG81_11250 ENOG4105C8Y Acetylornithine aminotransferase CDG81_11270 ENOG4105CI2 imidazolone-5-propionate hydrolase CDG81_11275 ENOG4107R1Y fructose-bisphosphate aldolase CDG81_11280 ENOG4107QKS N-acylglucosamine 2-epimerase CDG81_11295 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CDG81_11300 ENOG4105D56 permease protein CDG81_11310 ENOG41065HY 1,4-beta-cellobiosidase CDG81_11325 ENOG4105ETE Transcriptional regulator (LacI family CDG81_11330 ENOG4105DQQ Major facilitator superfamily MFS_1 CDG81_11340 ENOG4105DKQ ROK family CDG81_11345 ENOG4105C2J ABC transporter CDG81_11350 ENOG4105CNN ABC, transporter CDG81_11355 ENOG4105DFW ABC transporter CDG81_11385 ENOG4105F0H myo-inositol catabolism protein CDG81_11395 ENOG4105F8V Hydrolase, tatD family CDG81_11420 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CDG81_11425 ENOG41064MX Tetr family transcriptional regulator CDG81_11430 ENOG41064MX Tetr family transcriptional regulator CDG81_11470 ENOG4108UVJ appr-1-p processing domain protein CDG81_11475 ENOG4105CHH sulfate transporter CDG81_11480 ENOG4105W1Y Transcriptional regulator CDG81_11500 ENOG4105VEQ Cold shock protein CDG81_11520 ENOG4108JQ1 Dehydrogenase CDG81_11565 ENOG4107QN1 sodium solute CDG81_11575 ENOG4107QN1 sodium solute CDG81_11585 ENOG4105DY9 regulatoR CDG81_11590 ENOG4108HRK Histidine kinase CDG81_11595 ENOG4105BZU Histidine kinase CDG81_11635 ENOG41062D9 Histidine kinase CDG81_11665 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CDG81_11670 ENOG4105VPX protein, conserved in bacteria CDG81_11695 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CDG81_11710 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CDG81_11715 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) CDG81_11720 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CDG81_11755 ENOG4106NZI LysR family Transcriptional regulator CDG81_11810 ENOG4107W19 lmbE family CDG81_11825 ENOG41082BM Transcriptional regulator, arsr family CDG81_11870 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CDG81_11875 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CDG81_11890 ENOG4108IJ9 (ABC) transporter CDG81_11895 ENOG4105ETE Transcriptional regulator (LacI family CDG81_11910 ENOG4105BZW Glycerate kinase CDG81_11915 ENOG4105EKC CDG81_11930 ENOG4105ETE Transcriptional regulator (LacI family CDG81_11945 ENOG4105DET Rhamnulokinase CDG81_11950 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CDG81_11960 ENOG41080R8 Conserved Protein CDG81_11975 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CDG81_12025 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CDG81_12040 ENOG4105DIK (ABC) transporter CDG81_12050 ENOG4105EN6 Membrane CDG81_12060 ENOG4105C0I Conserved Protein CDG81_12095 ENOG4105C3Q Glycosyl transferase, family 2 CDG81_12100 ENOG4105EEI dihydropteroate synthase CDG81_12115 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CDG81_12130 ENOG4105DA5 (ABC) transporter CDG81_12145 ENOG4105CPC Aldo Keto reductase CDG81_12175 ENOG4108535 NAD dependent epimerase/dehydratase family CDG81_12190 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CDG81_12210 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CDG81_12215 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CDG81_12220 ENOG4105EUJ GTP cyclohydrolase i CDG81_12225 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CDG81_12230 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CDG81_12260 ENOG4108NJC CDG81_12265 ENOG4105MSY salicylate hydroxylase CDG81_12270 ENOG4108IG5 Transcriptional regulator CDG81_12290 ENOG4108DT4 serine threonine protein kinase CDG81_12390 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CDG81_12425 ENOG4105DEN Luciferase family CDG81_12430 ENOG4105E2R ROK family CDG81_12440 ENOG4107T94 Endo-14-beta-xylanase CDG81_12450 ENOG4108IJ9 (ABC) transporter CDG81_12455 ENOG4105CG3 alpha amylase, catalytic region CDG81_12475 ENOG4105ETE Transcriptional regulator (LacI family CDG81_12490 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CDG81_12550 ENOG4107R16 Multicopper oxidase CDG81_12555 ENOG4105VPX protein, conserved in bacteria CDG81_12625 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CDG81_12630 ENOG4105EHG Permease protein CDG81_12680 ENOG4105C57 major facilitator superfamily CDG81_12690 ENOG4107TCW O-succinylbenzoate synthase CDG81_12695 ENOG4107QZF nitrite reductase NADPH large subunit CDG81_12700 ENOG4107QZF nitrite reductase NADPH large subunit CDG81_12705 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CDG81_12710 ENOG4105E4F Isochorismate synthase CDG81_12715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CDG81_12730 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CDG81_12735 ENOG4107SCK Monooxygenase CDG81_12745 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CDG81_12760 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CDG81_12785 ENOG4107RTD sua5 ycio yrdc ywlc family protein CDG81_12815 ENOG4105S0E allantoin catabolism protein CDG81_12830 ENOG4105ETE Transcriptional regulator (LacI family CDG81_12835 ENOG4107QKS N-acylglucosamine 2-epimerase CDG81_12845 ENOG4108JQ7 (ABC) transporter CDG81_12870 ENOG4105EX0 alpha-galactosidase CDG81_12890 ENOG4105ESN nucleotide-binding protein CDG81_12890 ENOG4105ESN nucleotide-binding protein CDG81_12895 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein CDG81_12900 ENOG4105ESN nucleotide-binding protein CDG81_12930 ENOG4105DQE DNA ligase CDG81_12950 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CDG81_12965 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CDG81_12995 ENOG4105H1N peptidase, M24 CDG81_13060 ENOG41060M0 Crispr-associated protein, cse4 family CDG81_13100 ENOG4105EHG Permease protein CDG81_13105 ENOG4105E0A ABC, transporter CDG81_13130 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CDG81_13135 ENOG4108SM1 rRNA (Adenine-N(6)-)-methyltransferase CDG81_13145 ENOG4105Q56 cytochrome P450 CDG81_13155 ENOG4105CPC Aldo Keto reductase CDG81_13160 ENOG4108K6T Protein of unknown function (DUF1205) CDG81_13170 ENOG4107SQU synthase CDG81_13180 ENOG4107EEY synthase CDG81_13185 ENOG4107EEY synthase CDG81_13210 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CDG81_13220 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CDG81_13225 ENOG4106A3M Cytochrome p-450 CDG81_13255 ENOG4107QKG PfaD family CDG81_13320 ENOG4105CAQ asparagine synthetase CDG81_13330 ENOG4105CHR reductase CDG81_13335 ENOG4105ERH Fumarylacetoacetate hydrolase CDG81_13405 ENOG4105CNU cell division protein FtsK CDG81_13435 ENOG4107SCJ type I restriction enzyme EcoKI subunit R CDG81_13445 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CDG81_13485 ENOG4105C6Y Udp-glucose 6-dehydrogenase CDG81_13505 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CDG81_13525 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CDG81_13530 ENOG4108IAJ Nad-dependent epimerase dehydratase CDG81_13620 ENOG4105C6Y Udp-glucose 6-dehydrogenase CDG81_13645 ENOG4105EV8 ectoine hydroxylase CDG81_13675 ENOG4108UYI beta-alanyl-CoA ammonia lyase CDG81_13680 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_13690 ENOG4108JPW Aminotransferase CDG81_13700 ENOG4106A3M Cytochrome p-450 CDG81_13715 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) CDG81_13735 ENOG4105CFH Aspartokinase CDG81_13800 ENOG4108VJY integral membrane protein CDG81_13955 ENOG4108VQT Alpha beta hydrolase fold protein CDG81_13985 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CDG81_14010 ENOG4105DEU major facilitator superfamily CDG81_14020 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CDG81_14030 ENOG4105EFZ amidohydrolase CDG81_14035 ENOG4105FS0 cytoplasmic membrane protein CDG81_14045 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CDG81_14050 ENOG4105J0Q Transcriptional regulator CDG81_14125 ENOG4105DV0 amidase (EC 3.5.1.4 CDG81_14130 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) CDG81_14135 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) CDG81_14140 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) CDG81_14145 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) CDG81_14150 ENOG4105E5F proteasome CDG81_14155 ENOG4105PTV Nudix Hydrolase CDG81_14160 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CDG81_14190 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) CDG81_14240 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase CDG81_14270 ENOG4105GWZ Roadblock lc7 family protein CDG81_14280 ENOG4105C8N cysteinyl-tRNA synthetase CDG81_14300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CDG81_14315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDG81_14320 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CDG81_14330 ENOG4108ME1 Peptidase M55 D-aminopeptidase CDG81_14355 ENOG4105C5H ABC transporter CDG81_14375 ENOG4105BZU Histidine kinase CDG81_14385 ENOG4105VG1 fes assembly suf system protein CDG81_14390 ENOG4108UNV SUF system FeS assembly protein, NifU family CDG81_14400 ENOG4105C3K feS assembly ATPase SufC CDG81_14420 ENOG4107JC6 Membrane CDG81_14445 ENOG410600Z Regulatory protein MarR CDG81_14465 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CDG81_14475 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CDG81_14490 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CDG81_14495 ENOG4107QYV phosphohexose isomerase CDG81_14510 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) CDG81_14520 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CDG81_14610 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CDG81_14615 ENOG4105C45 hydrogenase expression formation protein (HypE) CDG81_14655 ENOG4105DPX Hydrogenase, large subunit CDG81_14665 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CDG81_14675 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CDG81_14695 ENOG4105C4R Atp-dependent dna helicase CDG81_14700 ENOG4105D9P serine threonine protein kinase CDG81_14795 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CDG81_14845 ENOG4105CP7 Triose-phosphate isomerase CDG81_14850 ENOG4105BZA Phosphoglycerate kinase CDG81_14860 ENOG4105CIE May be required for sporulation (By similarity) CDG81_14865 ENOG4105CHW UPF0052 protein CDG81_14870 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CDG81_14875 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CDG81_14885 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CDG81_14895 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CDG81_14900 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CDG81_14925 ENOG4105C85 amino acid CDG81_14930 ENOG4108Z6B deaminase CDG81_14945 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CDG81_14970 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CDG81_14980 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CDG81_14990 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CDG81_14995 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CDG81_15005 ENOG4105SKN orotidine 5''-phosphate decarboxylase CDG81_15015 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CDG81_15030 ENOG4105CXT aspartate transcarbamylase CDG81_15045 ENOG410803B Involved in the transcription termination process (By similarity) CDG81_15050 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CDG81_15085 ENOG4105MVE transcriptional regulator CDG81_15090 ENOG4105CPQ Dehydrogenase CDG81_15100 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CDG81_15105 ENOG4105D49 3-dehydroquinate synthase CDG81_15110 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CDG81_15115 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CDG81_15125 ENOG4105C5Y PTS System CDG81_15130 ENOG4105CI1 PTS System CDG81_15140 ENOG410849S phosphocarrier protein (HPr) CDG81_15145 ENOG4105E2X shikimate dehydrogenase CDG81_15160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CDG81_15205 ENOG4105C9M aspartyl-trna synthetase CDG81_15220 ENOG4107SJ9 decarboxylase CDG81_15270 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) CDG81_15275 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CDG81_15280 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CDG81_15295 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CDG81_15300 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CDG81_15305 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CDG81_15320 ENOG4105CDY transcriptional regulatory protein CDG81_15325 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CDG81_15330 ENOG4105C85 amino acid CDG81_15345 ENOG4108IMY Transcriptional regulator CDG81_15350 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CDG81_15400 ENOG4105DV0 amidase (EC 3.5.1.4 CDG81_15405 ENOG4105E1V na solute symporter CDG81_15420 ENOG4108YYC ycei family CDG81_15430 ENOG4105C22 threonyL-tRNA synthetase CDG81_15435 ENOG4105BZU Histidine kinase CDG81_15455 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CDG81_15460 ENOG41081JD Transcriptional regulator CDG81_15465 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CDG81_15470 ENOG4105IQ5 FAD linked oxidase domain protein CDG81_15475 ENOG4108QER Adenylate cyclase CDG81_15490 ENOG4105C26 Dehydrogenase CDG81_15525 ENOG4105KF0 sporulation and cell division protein, SsgA CDG81_15540 ENOG41082T9 Membrane CDG81_15545 ENOG4105DYW oxidoreductase CDG81_15550 ENOG4108JQ1 Dehydrogenase CDG81_15565 ENOG4105D9R oxidoreductase CDG81_15570 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_15575 ENOG4108ZGX Histidine kinase CDG81_15600 ENOG4105C1G acyl-Coa dehydrogenase CDG81_15605 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CDG81_15610 ENOG4105DRR Transcriptional regulator, GntR family CDG81_15640 ENOG4107R7Y intracellular protease Pfpi family CDG81_15650 ENOG4105D5U fad dependent oxidoreductase CDG81_15665 ENOG4105C8Y Acetylornithine aminotransferase CDG81_15680 ENOG4105EMN RNA polymerase sigma factor CDG81_15725 ENOG4107AQZ Membrane CDG81_15740 ENOG4105E0X reductase CDG81_15750 ENOG4107JTW chlorite dismutase CDG81_15760 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CDG81_15775 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_15780 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CDG81_15785 ENOG4105CHU acetyl-coa acetyltransferase CDG81_15790 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CDG81_15800 ENOG4106F60 Histidine kinase CDG81_15805 ENOG4105F44 Two component transcriptional regulator, winged helix family CDG81_15810 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CDG81_15815 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CDG81_15820 ENOG4105C0X amino acid CDG81_15825 ENOG4107VEG TrkA-N domain protein CDG81_15850 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CDG81_15915 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CDG81_15945 ENOG4105DGU Histone deacetylase CDG81_15950 ENOG4105KHC sulfurtransferase CDG81_15955 ENOG4107R5H iron (metal) dependent repressor, dtxr family CDG81_15960 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CDG81_15965 ENOG4105CMR udp-glucose 4-epimerase CDG81_15975 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CDG81_15990 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDG81_15995 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CDG81_16000 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CDG81_16015 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CDG81_16020 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CDG81_16025 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CDG81_16030 ENOG4105C99 atpase involved in dna repair CDG81_16040 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CDG81_16045 ENOG4105CDA abc transporter atp-binding protein CDG81_16050 ENOG4107UBR Extracellular solute-binding protein family 3 CDG81_16055 ENOG4105EAD ABC transporter CDG81_16060 ENOG4105DRP amino acid AbC transporter CDG81_16070 ENOG4105C01 Dihydroxy-acid dehydratase CDG81_16075 ENOG4108UHU Aldolase CDG81_16090 ENOG4105KC9 Modulates RecA activity (By similarity) CDG81_16095 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CDG81_16110 ENOG4107QRT dEAD DEAH box helicase CDG81_16130 ENOG4105EAH synthase CDG81_16145 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CDG81_16160 ENOG4105E9Q Acyl-transferase CDG81_16245 ENOG4107S1N anthranilate phosphoribosyltransferase CDG81_16265 ENOG4108ZRS Part of cytochrome c oxidase, its function is CDG81_16270 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CDG81_16285 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CDG81_16300 ENOG4105CPC Aldo Keto reductase CDG81_16305 ENOG4108YZT Adenosylcobinamide kinase CDG81_16330 ENOG4105CM2 brancheD-chain amino acid aminotransferase CDG81_16340 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CDG81_16360 ENOG4105ECP epimerase CDG81_16365 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CDG81_16390 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CDG81_16425 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CDG81_16430 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CDG81_16435 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CDG81_16465 ENOG4105RFA Lsr2-like protein CDG81_16475 ENOG4108RVA ribokinase CDG81_16485 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CDG81_16490 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CDG81_16495 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CDG81_16515 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CDG81_16520 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CDG81_16525 ENOG4107Y2X deaminase CDG81_16530 ENOG4105C7N Xanthine uracil vitamin C permease CDG81_16565 ENOG4105EHG Permease protein CDG81_16570 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CDG81_16600 ENOG4105C7K acetolactate synthase CDG81_16635 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CDG81_16640 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CDG81_16650 ENOG4108RQ5 Beta-lactamase domain-containing protein CDG81_16655 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CDG81_16690 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CDG81_16695 ENOG4107RKP Nicotinate phosphoribosyltransferase CDG81_16700 ENOG4108RWI nicotinamidase CDG81_16715 ENOG4107ZYJ bioY protein CDG81_16720 ENOG41080W3 amp-dependent synthetase and ligase CDG81_16730 ENOG4108JJB ABC transporter CDG81_16740 ENOG4105CHR reductase CDG81_16760 ENOG4105BZ9 Cytochrome C oxidase, subunit I CDG81_16805 ENOG4105CPC Aldo Keto reductase CDG81_16820 ENOG4105P4J Allophanate hydrolase, subunit 1 CDG81_16825 ENOG4105E7W lamb ycsf family protein CDG81_16855 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CDG81_16865 ENOG4105CAQ asparagine synthetase CDG81_16890 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CDG81_16910 ENOG4105CN8 Transcriptional regulator CDG81_16915 ENOG4105D2S major facilitator superfamily CDG81_16920 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CDG81_16970 ENOG4107QWG 2-Nitropropane dioxygenase CDG81_17020 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CDG81_17030 ENOG4108MR6 WD40-like Beta Propeller Repeat CDG81_17035 ENOG4105DDN Pentapeptide repeat-containing protein CDG81_17050 ENOG4108EUP Glycosyl hydrolase family 62 CDG81_17085 ENOG4106S2D Transcriptional regulator CDG81_17150 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDG81_17165 ENOG4108JJB ABC transporter CDG81_17170 ENOG4105H3G oxidoreductase CDG81_17180 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CDG81_17195 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CDG81_17200 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) CDG81_17205 ENOG4105CAK Cell division ATP-binding protein ftsE CDG81_17210 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CDG81_17235 ENOG4105DJZ UPF0182 protein CDG81_17270 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CDG81_17290 ENOG4105C1V Peptidase, M16 CDG81_17320 ENOG4107SVH Potassium channel protein CDG81_17345 ENOG4105C4R Atp-dependent dna helicase CDG81_17390 ENOG4108MUZ hydrolase CDG81_17420 ENOG4105C1J atp-dependent rna helicase CDG81_17440 ENOG4105DB7 PHP domain protein CDG81_17455 ENOG4105D7N magnesium and cobalt transport protein CorA CDG81_17475 ENOG4107FCW Abortive infection protein CDG81_17505 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CDG81_17520 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CDG81_17570 ENOG4105D7V transposase CDG81_17585 ENOG4105CI0 Citrate lyase CDG81_17590 ENOG4105CJW magnesium transporter CDG81_17605 ENOG4107ZBN O-methyltransferase CDG81_17610 ENOG4105DU6 RNA polymerase CDG81_17615 ENOG4106684 CDG81_17625 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CDG81_17640 ENOG4108UKI Enoyl-CoA hydratase CDG81_17645 ENOG4108R3E Dna-3-methyladenine glycosylase i CDG81_17675 ENOG4108URH decarboxylase CDG81_17680 ENOG4108URH decarboxylase CDG81_17695 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) CDG81_17715 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CDG81_17740 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CDG81_17750 ENOG4108Z4U Ferredoxin CDG81_17765 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) CDG81_17775 ENOG4107USK Extracellular solute-binding protein, family 5 CDG81_17780 ENOG4105CI3 gtp-binding protein typa CDG81_17795 ENOG4105M6F mutator MutT protein CDG81_17800 ENOG41062D9 Histidine kinase CDG81_17815 ENOG4105CJ1 ABC, transporter CDG81_17835 ENOG4108UCS ABC, transporter CDG81_17855 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CDG81_17860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CDG81_17865 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CDG81_17920 ENOG4105C7W Xanthine dehydrogenase CDG81_17925 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding CDG81_17930 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit CDG81_17935 ENOG41086D8 Transcriptional regulator CDG81_17995 ENOG4108VWQ crispr-associated protein CDG81_18005 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) CDG81_18010 ENOG4105PWE CRISPR-associated protein cas2 CDG81_18080 ENOG4105C3G gtp-binding protein CDG81_18100 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CDG81_18110 ENOG4105EYH Exonuclease CDG81_18125 ENOG4105CMG Carbohydrate kinase CDG81_18135 ENOG4105ETE Transcriptional regulator (LacI family CDG81_18150 ENOG4105CNN ABC, transporter CDG81_18155 ENOG4105C2J ABC transporter CDG81_18165 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CDG81_18175 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CDG81_18185 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CDG81_18200 ENOG4105CAY ferredoxin--nadp reductase CDG81_18205 ENOG4105C9Q fumarate hydratase class II CDG81_18210 ENOG4105BZU Histidine kinase CDG81_18220 ENOG4105ERX Dehydrogenase CDG81_18245 ENOG4107WFU Glutamate mutase subunit sigma CDG81_18250 ENOG4105CHR reductase CDG81_18270 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_18290 ENOG4105CIF Ornithine Cyclodeaminase CDG81_18325 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CDG81_18330 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CDG81_18345 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CDG81_18370 ENOG4105C84 Histidine ammonia-lyase CDG81_18380 ENOG4106NZI LysR family Transcriptional regulator CDG81_18385 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase CDG81_18405 ENOG4108IAB Phoh family CDG81_18440 ENOG4105C7Z Conserved Protein CDG81_18450 ENOG4107S1Q Phosphatase CDG81_18460 ENOG4105T1M mycothiol conjugate amidase mca CDG81_18470 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CDG81_18480 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CDG81_18510 ENOG4105CHU acetyl-coa acetyltransferase CDG81_18535 ENOG4105EHG Permease protein CDG81_18565 ENOG4108JQ7 (ABC) transporter CDG81_18575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDG81_18605 ENOG4105CSU acyl-Coa dehydrogenase CDG81_18620 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CDG81_18640 ENOG4105DXN mazG family CDG81_18805 ENOG4105D8V Glucose sorbosone dehydrogenase CDG81_18815 ENOG4105WN5 stage II sporulation protein CDG81_18835 ENOG4105BZU Histidine kinase CDG81_18840 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CDG81_18855 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CDG81_18860 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CDG81_18865 ENOG4105ESF Peptidoglycan binding domain protein CDG81_18890 ENOG4107RCI amp-dependent synthetase and ligase CDG81_18895 ENOG4105C5H ABC transporter CDG81_18900 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CDG81_18905 ENOG4105D01 (LipO)protein CDG81_18910 ENOG4108UMI ABC transporter, permease CDG81_18915 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CDG81_18920 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CDG81_18925 ENOG4106839 domain protein CDG81_18930 ENOG4105MS9 Resuscitation-promoting factor CDG81_18935 ENOG4105F8V Hydrolase, tatD family CDG81_18940 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CDG81_18945 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CDG81_18950 ENOG4105C26 Dehydrogenase CDG81_18955 ENOG4105C26 Dehydrogenase CDG81_19040 ENOG4105DZ1 carboxypeptidase CDG81_19045 ENOG4107H3J ribonuclease CDG81_19050 ENOG4105C31 Tryptophanyl-tRNA synthetase CDG81_19070 ENOG4105EDW glycosyl transferase, family 39 CDG81_19075 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) CDG81_19110 ENOG4105CGK Exodeoxyribonuclease III CDG81_19145 ENOG4107R5W Monooxygenase CDG81_19155 ENOG4107S6Z Na H antiporter CDG81_19225 ENOG4105EYF MMPL domain protein CDG81_19265 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CDG81_19295 ENOG4105DC1 bifunctional purine biosynthesis protein purh CDG81_19315 ENOG4105CMV Succinyl-CoA synthetase subunit beta CDG81_19325 ENOG4105DR5 peptidase CDG81_19335 ENOG4105CIG ABC transporter CDG81_19340 ENOG4105DIM ABC transporter CDG81_19385 ENOG4107TPY serine threonine protein kinase CDG81_19390 ENOG4105HEI LysR family (Transcriptional regulator CDG81_19395 ENOG4105FDR Membrane CDG81_19410 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_19430 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CDG81_19440 ENOG4107QVP Dehydrogenase CDG81_19475 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CDG81_19480 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CDG81_19490 ENOG4105DGI Alkaline phosphatase CDG81_19495 ENOG4105DGI Alkaline phosphatase CDG81_19505 ENOG4105D7V transposase CDG81_19515 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CDG81_19520 ENOG41080E2 ribosomal-protein-alanine acetyltransferase CDG81_19530 ENOG4105CNT hydrolase family 2 CDG81_19535 ENOG4105DHG Allantoate amidinohydrolase CDG81_19545 ENOG4105BZW Glycerate kinase CDG81_19550 ENOG41060W2 glyoxylate carboligase CDG81_19555 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CDG81_19565 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CDG81_19625 ENOG4107R9S Malate synthase CDG81_19630 ENOG4108FUF Transcriptional regulator, IclR family CDG81_19715 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CDG81_19725 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CDG81_19765 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CDG81_19770 ENOG4108UJD 30S ribosomal protein S9 CDG81_19775 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CDG81_19785 ENOG410646G Proteins of 100 residues with WXG CDG81_19795 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CDG81_19800 ENOG4105EC2 ftsk spoIIIe CDG81_19835 ENOG4108ZT0 50S ribosomal protein l17 CDG81_19840 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CDG81_19845 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CDG81_19850 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CDG81_19855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CDG81_19860 ENOG41067V7 50S ribosomal protein L36 CDG81_19865 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CDG81_19870 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CDG81_19890 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CDG81_19900 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CDG81_19905 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CDG81_19910 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CDG81_19915 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CDG81_19920 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CDG81_19925 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CDG81_19930 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CDG81_19935 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CDG81_19940 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CDG81_19945 ENOG41082SA 50s ribosomal protein l29 CDG81_19950 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CDG81_19955 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CDG81_19960 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CDG81_19965 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CDG81_19970 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CDG81_19975 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CDG81_19980 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CDG81_19985 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CDG81_19995 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CDG81_20000 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CDG81_20005 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CDG81_20010 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CDG81_20020 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CDG81_20025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CDG81_20035 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CDG81_20040 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CDG81_20100 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CDG81_20155 ENOG4105DHJ ABC, transporter CDG81_20210 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CDG81_20215 ENOG4108VZM 50s ribosomal protein L10 CDG81_20230 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CDG81_20235 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CDG81_20265 ENOG410900P UPF0336 protein CDG81_20270 ENOG4105WDJ 50S ribosomal protein L33 CDG81_20285 ENOG4105BZU Histidine kinase CDG81_20320 ENOG4105GWZ Roadblock lc7 family protein CDG81_20330 ENOG41062QD Membrane CDG81_20335 ENOG4107QN1 sodium solute CDG81_20340 ENOG4108J2P Alpha beta hydrolase fold CDG81_20360 ENOG4105KRQ Addiction module toxin, Txe YoeB family CDG81_20365 ENOG4105VTW prevent-host-death family CDG81_20375 ENOG4108VPT UPF0234 protein CDG81_20385 ENOG4105D0M Protease HtpX homolog CDG81_20395 ENOG4105CIK Amidinotransferase CDG81_20410 ENOG4105EAH synthase CDG81_20415 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CDG81_20430 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CDG81_20435 ENOG4105DF2 NADH dehydrogenase subunit j CDG81_20440 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CDG81_20445 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CDG81_20450 ENOG4108IEH NADH dehydrogenase subunit g CDG81_20465 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CDG81_20470 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CDG81_20475 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CDG81_20490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CDG81_20495 ENOG4105ECY inositol monophosphatase CDG81_20515 ENOG4105E4F Isochorismate synthase CDG81_20525 ENOG4105CD8 aminopeptidase N CDG81_20540 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CDG81_20545 ENOG4107SIQ Naphthoate synthase CDG81_20585 ENOG4105CSH Transporter CDG81_20595 ENOG4105MXW flavin reductase domain protein, FMN-binding CDG81_20610 ENOG4105F27 Major Facilitator CDG81_20615 ENOG4105CV8 reductase CDG81_20625 ENOG4105CHF Glutathione S-transferase CDG81_20630 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CDG81_20635 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CDG81_20640 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CDG81_20645 ENOG4105DK0 Indole-3-glycerol phosphate synthase CDG81_20650 ENOG4108I0Q anthranilate phosphoribosyltransferase CDG81_20655 ENOG4105DDQ anthranilate synthase CDG81_20660 ENOG4105CRQ synthase (Component I) CDG81_20670 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) CDG81_20700 ENOG4108ZGX Histidine kinase CDG81_20725 ENOG4108IGT Dipeptidase CDG81_20730 ENOG4108Z40 Transcriptional regulator CDG81_20735 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CDG81_20815 ENOG4105CRE cytochrome C CDG81_20825 ENOG4107QIV Cytochrome c biogenesis protein CDG81_20830 ENOG4107QX9 Thiol disulfide interChange protein CDG81_20835 ENOG4108RH7 phosphoglycerate mutase CDG81_20840 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CDG81_20875 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CDG81_20880 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CDG81_20885 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CDG81_20890 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CDG81_20905 ENOG4108RXW HAD-superfamily subfamily IB hydrolase CDG81_20955 ENOG4105II7 pyrroline-5-carboxylate reductase CDG81_20980 ENOG4105BZU Histidine kinase CDG81_20985 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CDG81_20995 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CDG81_21015 ENOG4107R4N Cell wall formation (By similarity) CDG81_21040 ENOG4105V9F hemagglutinin CDG81_21065 ENOG4106BRA Membrane CDG81_21085 ENOG4107U9B transcriptional regulator CDG81_21100 ENOG4105D7N magnesium and cobalt transport protein CorA CDG81_21145 ENOG41064MX Tetr family transcriptional regulator CDG81_21180 ENOG4105C1G acyl-Coa dehydrogenase CDG81_21190 ENOG4107QX3 carboxylase CDG81_21220 ENOG4105CV8 reductase CDG81_21225 ENOG41061H0 Monooxygenase CDG81_21235 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CDG81_21255 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CDG81_21260 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit CDG81_21265 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit CDG81_21270 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit CDG81_21275 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit CDG81_21280 ENOG4105DXM phenylacetic acid degradation protein CDG81_21295 ENOG4108IG5 Transcriptional regulator CDG81_21300 ENOG4107QTZ amino acid CDG81_21305 ENOG4107QTZ amino acid CDG81_21310 ENOG4107TE5 Lipid kinase CDG81_21320 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) CDG81_21325 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein CDG81_21345 ENOG4108Z9I -acetyltransferase CDG81_21365 ENOG4105MXW flavin reductase domain protein, FMN-binding CDG81_21385 ENOG4105CAQ asparagine synthetase CDG81_21395 ENOG4108IND Tetr family transcriptional regulator CDG81_21405 ENOG4105F27 Major Facilitator CDG81_21410 ENOG41084KP 4-oxalocrotonate tautomerase CDG81_21435 ENOG4105D8K carboxyl transferase CDG81_21485 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CDG81_21500 ENOG4105CK7 Sodium proline symporter CDG81_21520 ENOG4105CEY Amp-dependent synthetase and ligase CDG81_21560 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CDG81_21595 ENOG4105BZU Histidine kinase CDG81_21600 ENOG4108KGH TRANSCRIPTIONal CDG81_21605 ENOG4108UTW Plays a role in the regulation of phosphate uptake CDG81_21615 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CDG81_21620 ENOG4105E2Z phosphate ABC transporter (Permease CDG81_21635 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CDG81_21665 ENOG4105KHC sulfurtransferase CDG81_21670 ENOG4105PKJ carbohydrate binding CDG81_21685 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands CDG81_21705 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CDG81_21740 ENOG4105CXB phosphoribosylaminoimidazole synthetase CDG81_21770 ENOG4105BZP glycoside hydrolase 15-related CDG81_21775 ENOG4105CPQ Dehydrogenase CDG81_21825 ENOG4105BZ4 penicillin-binding protein CDG81_21840 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CDG81_21850 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) CDG81_21860 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CDG81_21865 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CDG81_21920 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 CDG81_21925 ENOG4105DXB Major Facilitator superfamily CDG81_21935 ENOG4105EMU Dehydrogenase CDG81_21940 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CDG81_21950 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_21955 ENOG4105BZU Histidine kinase CDG81_21960 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CDG81_21975 ENOG4105CJ1 ABC, transporter CDG81_21980 ENOG4108CDS Sucrose-6F-phosphate phosphohydrolase CDG81_21990 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_21995 ENOG4105BZU Histidine kinase CDG81_22005 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CDG81_22020 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) CDG81_22115 ENOG4105Q26 Siderophore-interacting protein CDG81_22125 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) CDG81_22140 ENOG4105DRP amino acid AbC transporter CDG81_22145 ENOG4108HW3 (ABC) transporter CDG81_22150 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CDG81_22170 ENOG4105CPP Dehydrogenase, E1 component CDG81_22175 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 CDG81_22200 ENOG4108R86 Transcriptional regulator CDG81_22215 ENOG4105C8V SAICAR synthetase CDG81_22225 ENOG4105C83 adenylosuccinate lyase CDG81_22240 ENOG4105KPY Small multidrug resistance protein CDG81_22255 ENOG4105C5W Aldolase CDG81_22270 ENOG4105C12 Phosphoribosylglycinamide synthetase CDG81_22280 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CDG81_22320 ENOG4105CE4 GlcNAc 6-P deacetylase CDG81_22350 ENOG4107QVI Methyltransferase, type 11 CDG81_22360 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CDG81_22405 ENOG4105D94 Major Facilitator Superfamily CDG81_22445 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CDG81_22455 ENOG4108YYC ycei family CDG81_22460 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDG81_22515 ENOG4107U9T Pfam:Ribonuclease_BN CDG81_22545 ENOG4105KNI merR family transcriptional Regulator CDG81_22550 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CDG81_22555 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CDG81_22560 ENOG4105CFG Acts as a chaperone (By similarity) CDG81_22570 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CDG81_22575 ENOG4105W1N transcriptional regulator CDG81_22580 ENOG410814C multidrug resistance protein CDG81_22645 ENOG4105DHP deoxycytidine triphosphate deaminase CDG81_22655 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CDG81_22660 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CDG81_22710 ENOG4108PSK reductase CDG81_22730 ENOG4105C09 Bile acid CDG81_22760 ENOG4105D8X mechanosensitive ion channel CDG81_22765 ENOG41083TI Protein CrcB homolog CDG81_22770 ENOG41083YR Protein CrcB homolog CDG81_22790 ENOG4107TXC Transcriptional regulator CDG81_22805 ENOG4105CSU acyl-Coa dehydrogenase CDG81_22820 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CDG81_22855 ENOG41064MX Tetr family transcriptional regulator CDG81_22860 ENOG4108IG5 Transcriptional regulator CDG81_22865 ENOG4108PYU two-component system response regulator CDG81_22880 ENOG4105CHR reductase CDG81_22890 ENOG410839H phosphoribosylformylglycinamidine synthase CDG81_22895 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CDG81_22900 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CDG81_22910 ENOG4105BZU Histidine kinase CDG81_22915 ENOG4105BZU Histidine kinase CDG81_22940 ENOG4105BZU Histidine kinase CDG81_22950 ENOG4105WH1 Two component transcriptional regulator luxr family CDG81_22960 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CDG81_23010 ENOG4105C8T Leucyl-tRNA synthetase CDG81_23020 ENOG41081DT UPF0301 protein CDG81_23055 ENOG4107QPV Serine Threonine protein kinase CDG81_23075 ENOG4105C3M thioredoxin reductase CDG81_23080 ENOG4108E1C hydrolase CDG81_23090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CDG81_23095 ENOG4105CPF Cell wall formation (By similarity) CDG81_23105 ENOG4107QJE Chromosome Partitioning Protein CDG81_23110 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CDG81_23125 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CDG81_23130 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CDG81_23135 ENOG41084CH 50S ribosomal protein l34