locus-tag	class	description
Amir_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Amir_0002	COG0592	DNA-directed DNA polymerase activity
Amir_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Amir_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Amir_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Amir_0010	COG2259	Doxx family
Amir_0013	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Amir_0014	COG0705	Rhomboid family
Amir_0017	COG3764	Sortase (surface protein transpeptidase)
Amir_0021	COG0515	serine threonine protein kinase
Amir_0021	COG2815	serine threonine protein kinase
Amir_0022	COG0515	serine threonine protein kinase
Amir_0023	COG0768	penicillin binding
Amir_0026	COG1716	ATPase activity
Amir_0027	COG1716	ATPase activity
Amir_0032	COG1309	transcriptional regulator
Amir_0034	COG2211	Major facilitator Superfamily
Amir_0035	COG0300	oxidoreductase activity
Amir_0038	COG3281	Trehalose synthase
Amir_0044	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Amir_0049	COG0405	Gamma-glutamyltransferase
Amir_0055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Amir_0058	COG2226	methyltransferase
Amir_0064	COG3275	phosphorelay sensor kinase activity
Amir_0067	COG3279	Response regulator of the LytR AlgR family
Amir_0069	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Amir_0071	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Amir_0076	COG0584	glycerophosphoryl diester phosphodiesterase
Amir_0079	COG0653	protein targeting
Amir_0082	COG1528	Iron-storage protein
Amir_0092	COG1271	oxidase subunit
Amir_0093	COG1294	oxidase, subunit
Amir_0095	COG4988	ABC transporter
Amir_0098	COG0454	-acetyltransferase
Amir_0110	COG1501	Belongs to the glycosyl hydrolase 31 family
Amir_0115	COG0754	glutathionylspermidine amidase activity
Amir_0116	COG3766	membrane
Amir_0118	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Amir_0119	COG0579	oxidoreductase
Amir_0121	COG0561	phosphatase activity
Amir_0123	COG0463	Glycosyl transferase, family 2
Amir_0127	COG1216	Glycosyl transferase, family 2
Amir_0132	COG1216	Glycosyl transferase, family 2
Amir_0141	COG2234	aminopeptidase activity
Amir_0143	COG0737	Belongs to the 5'-nucleotidase family
Amir_0143	COG1525	nuclease
Amir_0143	COG4085	toxin activity
Amir_0146	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Amir_0152	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Amir_0154	COG1686	Belongs to the peptidase S11 family
Amir_0155	COG5295	Hep Hag repeat protein
Amir_0155	COG4932	domain protein
Amir_0164	COG0183	Belongs to the thiolase family
Amir_0168	COG0287	Prephenate dehydrogenase
Amir_0169	COG1473	amidohydrolase
Amir_0185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Amir_0191	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Amir_0202	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Amir_0203	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Amir_0205	COG3903	Transcriptional regulator
Amir_0205	COG3629	intracellular signal transduction
Amir_0206	COG0747	negative chemotaxis
Amir_0209	COG0444	Belongs to the ABC transporter superfamily
Amir_0210	COG4608	Belongs to the ABC transporter superfamily
Amir_0211	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Amir_0219	COG1070	Carbohydrate kinase
Amir_0223	COG1764	response to oxidative stress
Amir_0225	COG0431	NADPH-dependent FMN reductase
Amir_0233	COG1408	metallophosphoesterase
Amir_0251	COG0592	DNA-directed DNA polymerase activity
Amir_0252	COG2814	Major facilitator Superfamily
Amir_0256	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Amir_0259	COG0596	Alpha beta hydrolase
Amir_0261	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Amir_0262	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Amir_0265	COG3844	kynureninase activity
Amir_0267	COG1522	sequence-specific DNA binding
Amir_0268	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Amir_0269	COG1737	Transcriptional regulator
Amir_0271	COG3876	Protein conserved in bacteria
Amir_0273	COG1472	Belongs to the glycosyl hydrolase 3 family
Amir_0283	COG1111	helicase
Amir_0283	COG1205	dead DEAH box helicase
Amir_0284	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Amir_0291	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Amir_0291	COG1754	DNA topoisomerase type I activity
Amir_0293	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Amir_0294	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Amir_0297	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Amir_0298	COG1120	ATPase activity
Amir_0307	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Amir_0310	COG0037	tRNA processing
Amir_0313	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Amir_0314	COG0302	gtp cyclohydrolase
Amir_0315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Amir_0316	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Amir_0320	COG0649	NAD binding
Amir_0325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Amir_0326	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Amir_0327	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Amir_0329	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Amir_0331	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_0332	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_0333	COG1120	ATPase activity
Amir_0335	COG0542	response to heat
Amir_0336	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Amir_0338	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Amir_0343	COG1194	a g-specific adenine glycosylase
Amir_0346	COG1609	Transcriptional regulator
Amir_0348	COG1653	transport
Amir_0349	COG1175	transmembrane transport
Amir_0350	COG3833	ABC-type maltose transport systems, permease component
Amir_0353	COG1121	(ABC) transporter
Amir_0354	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Amir_0355	COG3706	GGDEF domain
Amir_0355	COG0745	RESPONSE REGULATOR receiver
Amir_0360	COG0215	cysteine-tRNA ligase activity
Amir_0362	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Amir_0363	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Amir_0364	COG1329	Transcriptional regulator
Amir_0368	COG4221	oxidoreductase activity
Amir_0371	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Amir_0378	COG2205	protein histidine kinase activity
Amir_0379	COG0745	RESPONSE REGULATOR receiver
Amir_0385	COG3629	intracellular signal transduction
Amir_0385	COG3903	Transcriptional regulator
Amir_0389	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_0390	COG0583	DNA-binding transcription factor activity
Amir_0392	COG1404	Belongs to the peptidase S8 family
Amir_0393	COG0179	Fumarylacetoacetate (FAA) hydrolase
Amir_0394	COG4948	Mandelate Racemase Muconate Lactonizing
Amir_0395	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_0399	COG2186	Transcriptional regulator
Amir_0400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Amir_0402	COG1175	transmembrane transport
Amir_0404	COG2188	Transcriptional regulator
Amir_0405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Amir_0406	COG3384	dioxygenase
Amir_0407	COG0352	thiamine-phosphate diphosphorylase activity
Amir_0410	COG2022	thiamine diphosphate biosynthetic process
Amir_0412	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Amir_0418	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_0424	COG0351	phosphomethylpyrimidine kinase
Amir_0425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Amir_0430	COG1802	Transcriptional regulator
Amir_0432	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Amir_0436	COG0688	phosphatidylethanolamine metabolic process
Amir_0440	COG1278	Cold shock
Amir_0442	COG0459	protein refolding
Amir_0445	COG3142	Participates in the control of copper homeostasis
Amir_0449	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Amir_0452	COG4948	Mandelate Racemase Muconate Lactonizing
Amir_0459	COG2018	Roadblock/LC7 domain
Amir_0467	COG0315	cyclic pyranopterin monophosphate synthase activity
Amir_0467	COG0521	Mo-molybdopterin cofactor biosynthetic process
Amir_0469	COG1388	LysM domain
Amir_0471	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Amir_0472	COG1846	Transcriptional regulator
Amir_0476	COG3304	Inner membrane component domain
Amir_0481	COG1278	Cold shock
Amir_0483	COG2814	Major facilitator Superfamily
Amir_0488	COG2252	PERMEase
Amir_0490	COG2814	Major facilitator Superfamily
Amir_0493	COG0488	(ABC) transporter
Amir_0496	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Amir_0500	COG5492	domain, Protein
Amir_0501	COG0259	pyridoxamine-phosphate oxidase activity
Amir_0502	COG0829	nickel cation binding
Amir_0504	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Amir_0506	COG0804	urea catabolic process
Amir_0507	COG0832	Belongs to the urease beta subunit family
Amir_0508	COG0831	urea catabolic process
Amir_0513	COG2197	response regulator
Amir_0519	COG1132	(ABC) transporter
Amir_0520	COG1132	(ABC) transporter
Amir_0521	COG1309	transcriptional regulator
Amir_0522	COG0531	amino acid
Amir_0523	COG2017	converts alpha-aldose to the beta-anomer
Amir_0524	COG1228	amidohydrolase
Amir_0525	COG1960	acyl-CoA dehydrogenase activity
Amir_0529	COG0415	Belongs to the DNA photolyase family
Amir_0530	COG2197	response regulator
Amir_0532	COG1668	transmembrane transport
Amir_0533	COG4152	abc transporter atp-binding protein
Amir_0538	COG0402	S-adenosylhomocysteine deaminase activity
Amir_0539	COG2130	NADP-dependent
Amir_0542	COG1674	ftsk spoiiie
Amir_0547	COG2267	carboxylic ester hydrolase activity
Amir_0548	COG0583	DNA-binding transcription factor activity
Amir_0549	COG0384	phenazine biosynthesis protein PhzF
Amir_0550	COG0583	DNA-binding transcription factor activity
Amir_0551	COG0702	epimerase
Amir_0552	COG1733	regulation of RNA biosynthetic process
Amir_0559	COG2197	response regulator
Amir_0561	COG4249	Peptidase C14 caspase catalytic subunit p20
Amir_0561	COG2319	Wd-40 repeat
Amir_0572	COG3209	COG3209 Rhs family protein
Amir_0576	COG3903	Transcriptional regulator
Amir_0576	COG3629	intracellular signal transduction
Amir_0590	COG0482	sulfurtransferase activity
Amir_0593	COG1104	cysteine desulfurase activity
Amir_0594	COG1061	Type III restriction enzyme res subunit
Amir_0595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Amir_0601	COG2197	response regulator
Amir_0602	COG5002	protein histidine kinase activity
Amir_0602	COG3447	MASE1 domain protein
Amir_0602	COG5001	Diguanylate cyclase
Amir_0603	COG0778	Nitroreductase
Amir_0604	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Amir_0605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Amir_0607	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Amir_0613	COG2205	protein histidine kinase activity
Amir_0618	COG1349	DNA-binding transcription factor activity
Amir_0620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Amir_0622	COG0521	Mo-molybdopterin cofactor biosynthetic process
Amir_0622	COG0315	cyclic pyranopterin monophosphate synthase activity
Amir_0624	COG1970	mechanosensitive ion channel activity
Amir_0627	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Amir_0628	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Amir_0630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amir_0635	COG0515	serine threonine protein kinase
Amir_0635	COG2815	serine threonine protein kinase
Amir_0642	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amir_0643	COG0084	hydrolase, TatD family'
Amir_0644	COG3583	domain protein
Amir_0645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Amir_0646	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Amir_0647	COG2011	ABC-type metal ion transport system permease component
Amir_0649	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Amir_0650	COG0488	(ABC) transporter
Amir_0652	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_0653	COG0193	aminoacyl-tRNA hydrolase activity
Amir_0657	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Amir_0658	COG0745	RESPONSE REGULATOR receiver
Amir_0658	COG3706	GGDEF domain
Amir_0663	COG2133	pyrroloquinoline quinone binding
Amir_0667	COG3956	TIGRFAM MazG family protein
Amir_0668	COG4946	Tricorn protease homolog
Amir_0668	COG0793	Belongs to the peptidase S41A family
Amir_0671	COG0148	phosphopyruvate hydratase activity
Amir_0676	COG4166	transmembrane transport
Amir_0680	COG4608	Belongs to the ABC transporter superfamily
Amir_0685	COG0714	Associated with various cellular activities
Amir_0699	COG0183	Belongs to the thiolase family
Amir_0705	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Amir_0707	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Amir_0709	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Amir_0712	COG1331	Highly conserved protein containing a thioredoxin domain
Amir_0714	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Amir_0717	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Amir_0719	COG1793	dna ligase
Amir_0720	COG0114	fumarate hydratase activity
Amir_0721	COG0492	ferredoxin-NADP+ reductase activity
Amir_0725	COG1722	exodeoxyribonuclease VII activity
Amir_0727	COG1570	exodeoxyribonuclease VII activity
Amir_0733	COG0419	ATPase involved in DNA repair
Amir_0736	COG0012	GTP binding
Amir_0743	COG1051	belongs to the nudix hydrolase family
Amir_0745	COG2154	pterin-4-alpha-carbinolamine dehydratase
Amir_0747	COG4149	molybdate abc transporter
Amir_0748	COG3842	ATPase activity
Amir_0751	COG1131	(ABC) transporter
Amir_0755	COG0494	nUDIX hydrolase
Amir_0756	COG0180	Tryptophanyl-tRNA synthetase
Amir_0760	COG0747	negative chemotaxis
Amir_0761	COG4166	transmembrane transport
Amir_0765	COG4608	Belongs to the ABC transporter superfamily
Amir_0766	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Amir_0773	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amir_0774	COG1611	Belongs to the LOG family
Amir_0775	COG1611	Belongs to the LOG family
Amir_0777	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Amir_0781	COG0519	Catalyzes the synthesis of GMP from XMP
Amir_0786	COG1024	Enoyl-CoA hydratase
Amir_0787	COG3327	negative regulation of DNA-templated transcription, initiation
Amir_0789	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Amir_0790	COG0583	DNA-binding transcription factor activity
Amir_0791	COG2814	Major facilitator Superfamily
Amir_0793	COG0297	glycogen (starch) synthase activity
Amir_0794	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Amir_0798	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Amir_0802	COG2239	Acts as a magnesium transporter
Amir_0803	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
Amir_0816	COG0598	Magnesium transport protein CorA
Amir_0824	COG0513	Belongs to the DEAD box helicase family
Amir_0835	COG0243	molybdopterin cofactor binding
Amir_0836	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Amir_0837	COG2223	nitrite transmembrane transporter activity
Amir_0838	COG2146	nitrite reductase [NAD(P)H] activity
Amir_0838	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Amir_0839	COG2146	nitrite reductase [NAD(P)H] activity
Amir_0839	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Amir_0844	COG0745	RESPONSE REGULATOR receiver
Amir_0845	COG2205	protein histidine kinase activity
Amir_0852	COG0210	DNA helicase
Amir_0855	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_0856	COG0583	DNA-binding transcription factor activity
Amir_0864	COG0612	Peptidase, M16
Amir_0866	COG1940	carbohydrate kinase activity
Amir_0866	COG1846	Transcriptional regulator
Amir_0872	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Amir_0881	COG0328	RNA-DNA hybrid ribonuclease activity
Amir_0881	COG0406	alpha-ribazole phosphatase activity
Amir_0882	COG0431	NADPH-dependent FMN reductase
Amir_0889	COG0791	NLP P60 protein
Amir_0893	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Amir_0899	COG3842	ATPase activity
Amir_0904	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Amir_0908	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Amir_0908	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Amir_0909	COG0174	glutamine synthetase
Amir_0913	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Amir_0934	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Amir_0941	COG1615	UPF0182 protein
Amir_0944	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Amir_0945	COG2884	Cell division ATP-binding protein ftsE
Amir_0946	COG2177	Part of the ABC transporter FtsEX involved in
Amir_0947	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Amir_0948	COG2197	response regulator
Amir_0949	COG4585	Histidine kinase
Amir_0951	COG1643	Atp-dependent helicase
Amir_0953	COG0454	-acetyltransferase
Amir_0953	COG0456	acetyltransferase
Amir_0954	COG2814	Major facilitator Superfamily
Amir_0956	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Amir_0957	COG0515	serine threonine protein kinase
Amir_0957	COG2815	serine threonine protein kinase
Amir_0959	COG0732	type I restriction modification DNA specificity domain
Amir_0971	COG1175	transmembrane transport
Amir_0972	COG0395	ABC-type sugar transport system, permease component
Amir_0975	COG1609	Transcriptional regulator
Amir_0976	COG3903	Transcriptional regulator
Amir_0976	COG3629	intracellular signal transduction
Amir_0984	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Amir_0985	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Amir_0986	COG0235	Class ii aldolase
Amir_0987	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Amir_0989	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Amir_0990	COG0560	Phosphoserine phosphatase
Amir_0990	COG3830	Belongs to the UPF0237 family
Amir_1001	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Amir_1003	COG1335	isochorismatase
Amir_1004	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Amir_1005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Amir_1012	COG1234	tRNA 3'-trailer cleavage
Amir_1013	COG3386	PFAM SMP-30 Gluconolaconase
Amir_1015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Amir_1016	COG1234	tRNA 3'-trailer cleavage
Amir_1020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Amir_1021	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Amir_1025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_1026	COG2072	flavoprotein involved in K transport
Amir_1027	COG0586	Pfam SNARE associated Golgi protein
Amir_1036	COG2949	membrane
Amir_1037	COG1316	TRANSCRIPTIONal
Amir_1038	COG0752	glycyl-tRNA synthetase alpha subunit
Amir_1038	COG0751	glycine-tRNA ligase activity
Amir_1040	COG4213	ABC transporter substrate-binding protein
Amir_1042	COG1278	Cold shock
Amir_1044	COG3345	alpha-galactosidase
Amir_1046	COG4279	zinc finger
Amir_1047	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Amir_1055	COG0488	(ABC) transporter
Amir_1056	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Amir_1062	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Amir_1062	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Amir_1068	COG1846	Transcriptional regulator
Amir_1069	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Amir_1073	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Amir_1073	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Amir_1080	COG4106	trans-aconitate 2-methyltransferase activity
Amir_1081	COG0506	proline dehydrogenase activity
Amir_1082	COG1012	belongs to the aldehyde dehydrogenase family
Amir_1084	COG0706	membrane insertase activity
Amir_1089	COG1012	belongs to the aldehyde dehydrogenase family
Amir_1098	COG0740	serine-type endopeptidase activity
Amir_1099	COG0740	serine-type endopeptidase activity
Amir_1119	COG1609	Transcriptional regulator
Amir_1120	COG2223	nitrite transmembrane transporter activity
Amir_1122	COG3336	cytochrome c oxidase
Amir_1129	COG2902	Dehydrogenase
Amir_1134	COG0366	Alpha amylase catalytic
Amir_1136	COG0668	transmembrane transport
Amir_1137	COG1505	serine-type exopeptidase activity
Amir_1141	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Amir_1143	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Amir_1149	COG4552	Acetyltransferase involved in intracellular survival and related
Amir_1151	COG0583	DNA-binding transcription factor activity
Amir_1152	COG0544	peptidyl-prolyl cis-trans isomerase activity
Amir_1153	COG0740	serine-type endopeptidase activity
Amir_1154	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Amir_1157	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Amir_1165	COG0525	valine-tRNA ligase activity
Amir_1166	COG0285	dihydrofolate synthase activity
Amir_1172	COG0105	UTP biosynthetic process
Amir_1173	COG1131	(ABC) transporter
Amir_1175	COG0842	Transport permease protein
Amir_1186	COG1530	ribonuclease E activity
Amir_1186	COG1530	ribonuclease E activity
Amir_1187	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Amir_1188	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Amir_1189	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Amir_1191	COG0477	Major facilitator Superfamily
Amir_1194	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Amir_1197	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Amir_1198	COG0799	negative regulation of ribosome biogenesis
Amir_1200	COG2755	lipolytic protein G-D-S-L family
Amir_1201	COG1307	EDD domain protein, DegV family
Amir_1202	COG1555	photosystem II stabilization
Amir_1202	COG1596	polysaccharide export
Amir_1207	COG0268	Binds directly to 16S ribosomal RNA
Amir_1213	COG2308	Evidence 4 Homologs of previously reported genes of
Amir_1215	COG1305	Transglutaminase-like
Amir_1216	COG0481	GTPase activity
Amir_1219	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Amir_1223	COG0531	amino acid
Amir_1225	COG0604	alcohol dehydrogenase
Amir_1228	COG2732	(Barnase) inhibitor
Amir_1232	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amir_1233	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Amir_1239	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Amir_1241	COG1420	regulation of RNA biosynthetic process
Amir_1242	COG0484	heat shock protein binding
Amir_1246	COG0596	Alpha beta hydrolase
Amir_1247	COG0537	adenosine 5'-monophosphoramidase activity
Amir_1250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Amir_1254	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Amir_1255	COG1381	Involved in DNA repair and RecF pathway recombination
Amir_1256	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Amir_1259	COG0701	Predicted permease
Amir_1266	COG0423	glycine-tRNA ligase activity
Amir_1271	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Amir_1273	COG3340	Belongs to the peptidase S51 family
Amir_1274	COG1595	DNA-templated transcription, initiation
Amir_1275	COG0358	DNA primase activity
Amir_1279	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Amir_1280	COG2188	Transcriptional regulator
Amir_1282	COG0494	nUDIX hydrolase
Amir_1284	COG2186	Transcriptional regulator
Amir_1294	COG0582	viral genome integration into host DNA
Amir_1297	COG4106	trans-aconitate 2-methyltransferase activity
Amir_1299	COG1316	TRANSCRIPTIONal
Amir_1301	COG0726	polysaccharide deacetylase
Amir_1303	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
Amir_1304	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Amir_1306	COG5001	Diguanylate cyclase
Amir_1309	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Amir_1310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Amir_1312	COG2084	Dehydrogenase
Amir_1319	COG1132	(ABC) transporter
Amir_1320	COG1132	(ABC) transporter
Amir_1322	COG0515	serine threonine protein kinase
Amir_1325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amir_1326	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amir_1330	COG3201	nicotinamide mononucleotide transporter
Amir_1331	COG1653	transport
Amir_1333	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Amir_1340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Amir_1344	COG0321	lipoyl(octanoyl) transferase activity
Amir_1347	COG0702	epimerase
Amir_1350	COG0508	dehydrogenase complex catalyzes the overall conversion of
Amir_1351	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Amir_1356	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Amir_1357	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Amir_1360	COG0667	Aldo Keto reductase
Amir_1367	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Amir_1369	COG0204	Acyl-transferase
Amir_1369	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_1370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Amir_1373	COG1845	cytochrome c oxidase, subunit III
Amir_1374	COG2010	Cytochrome c
Amir_1376	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Amir_1382	COG0438	transferase activity, transferring glycosyl groups
Amir_1387	COG0003	Pfam Anion-transporting ATPase
Amir_1389	COG1940	carbohydrate kinase activity
Amir_1395	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Amir_1402	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Amir_1407	COG0442	prolyl-tRNA aminoacylation
Amir_1413	COG1201	RNA secondary structure unwinding
Amir_1415	COG0443	Heat shock 70 kDa protein
Amir_1416	COG2814	Major facilitator Superfamily
Amir_1419	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Amir_1420	COG2137	regulation of response to DNA damage stimulus
Amir_1422	COG0800	Aldolase
Amir_1432	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Amir_1434	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Amir_1436	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Amir_1439	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Amir_1440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Amir_1442	COG1196	nuclear chromosome segregation
Amir_1444	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amir_1446	COG0642	Histidine kinase
Amir_1447	COG0745	RESPONSE REGULATOR receiver
Amir_1448	COG1126	abc transporter atp-binding protein
Amir_1450	COG0765	amino acid transport
Amir_1451	COG0765	amino acid transport
Amir_1457	COG1515	deoxyribonuclease V activity
Amir_1458	COG1486	melibiose metabolic process
Amir_1459	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Amir_1460	COG2936	dipeptidyl-peptidase activity
Amir_1462	COG1506	peptidase
Amir_1462	COG4946	Tricorn protease homolog
Amir_1462	COG0823	Involved in the tonB-independent uptake of proteins
Amir_1463	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Amir_1464	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Amir_1468	COG0123	including yeast histone deacetylase and acetoin utilization protein
Amir_1470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amir_1471	COG2188	Transcriptional regulator
Amir_1475	COG1690	Belongs to the RtcB family
Amir_1485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Amir_1487	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amir_1488	COG4948	Mandelate Racemase Muconate Lactonizing
Amir_1494	COG1490	D-aminoacyl-tRNA deacylase activity
Amir_1495	COG2890	protein-(glutamine-N5) methyltransferase activity
Amir_1499	COG2313	pseudouridylate synthase activity
Amir_1505	COG4214	carbohydrate transport
Amir_1515	COG0756	dUTP diphosphatase activity
Amir_1521	COG0569	domain protein
Amir_1522	COG0531	amino acid
Amir_1523	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Amir_1524	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Amir_1526	COG0745	RESPONSE REGULATOR receiver
Amir_1527	COG2205	protein histidine kinase activity
Amir_1543	COG1024	Enoyl-CoA hydratase
Amir_1543	COG1250	3-hydroxyacyl-CoA dehydrogenase
Amir_1548	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Amir_1549	COG2197	response regulator
Amir_1552	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Amir_1555	COG1404	Belongs to the peptidase S8 family
Amir_1559	COG3220	belongs to the UPF0276 family
Amir_1565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Amir_1569	COG1960	acyl-CoA dehydrogenase activity
Amir_1570	COG1960	acyl-CoA dehydrogenase activity
Amir_1571	COG1793	dna ligase
Amir_1571	COG3285	dna ligase
Amir_1578	COG5006	permease, DMT superfamily
Amir_1579	COG1793	dna ligase
Amir_1583	COG0488	(ABC) transporter
Amir_1585	COG2706	6-phosphogluconolactonase activity
Amir_1586	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Amir_1591	COG1316	TRANSCRIPTIONal
Amir_1593	COG0671	phosphoesterase, PA-phosphatase related
Amir_1595	COG0653	protein targeting
Amir_1598	COG1960	acyl-CoA dehydrogenase activity
Amir_1603	COG1309	transcriptional regulator
Amir_1612	COG0475	glutathione-regulated potassium exporter activity
Amir_1616	COG1160	GTP binding
Amir_1617	COG2197	response regulator
Amir_1618	COG4585	Histidine kinase
Amir_1662	COG0328	RNA-DNA hybrid ribonuclease activity
Amir_1665	COG3345	alpha-galactosidase
Amir_1666	COG3903	Transcriptional regulator
Amir_1666	COG3629	intracellular signal transduction
Amir_1670	COG0410	ABC transporter
Amir_1680	COG0601	transmembrane transport
Amir_1681	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amir_1682	COG0444	Belongs to the ABC transporter superfamily
Amir_1688	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Amir_1689	COG2318	DinB family
Amir_1690	COG2255	four-way junction helicase activity
Amir_1691	COG0632	four-way junction helicase activity
Amir_1696	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Amir_1697	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Amir_1698	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Amir_1699	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Amir_1701	COG0124	histidyl-tRNA synthetase
Amir_1712	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Amir_1713	COG0439	Biotin carboxylase
Amir_1719	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Amir_1722	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Amir_1723	COG2205	protein histidine kinase activity
Amir_1724	COG0745	RESPONSE REGULATOR receiver
Amir_1726	COG2372	response to copper ion
Amir_1731	COG0673	inositol 2-dehydrogenase activity
Amir_1734	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Amir_1737	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Amir_1746	COG2244	polysaccharide biosynthetic process
Amir_1757	COG2153	protein acetylation
Amir_1763	COG0667	Aldo Keto reductase
Amir_1764	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Amir_1764	COG2226	methyltransferase
Amir_1764	COG0596	Alpha beta hydrolase
Amir_1765	COG1024	Enoyl-CoA hydratase
Amir_1770	COG1295	ribonuclease BN
Amir_1773	COG1126	abc transporter atp-binding protein
Amir_1774	COG0765	amino acid transport
Amir_1776	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Amir_1783	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Amir_1787	COG0395	ABC-type sugar transport system, permease component
Amir_1788	COG2723	6-phospho-beta-galactosidase activity
Amir_1792	COG5416	Lipopolysaccharide assembly protein A domain
Amir_1793	COG2319	Wd-40 repeat
Amir_1793	COG4249	Peptidase C14 caspase catalytic subunit p20
Amir_1794	COG1940	carbohydrate kinase activity
Amir_1795	COG2115	Belongs to the xylose isomerase family
Amir_1796	COG1070	Carbohydrate kinase
Amir_1802	COG2207	Transcriptional regulator
Amir_1802	COG3708	Transcriptional regulator
Amir_1812	COG0640	Transcriptional regulator
Amir_1820	COG0791	NLP P60 protein
Amir_1824	COG1609	Transcriptional regulator
Amir_1825	COG1609	Transcriptional regulator
Amir_1828	COG3458	cephalosporin-C deacetylase activity
Amir_1833	COG4941	Belongs to the sigma-70 factor family
Amir_1839	COG0492	ferredoxin-NADP+ reductase activity
Amir_1840	COG1785	Belongs to the alkaline phosphatase family
Amir_1843	COG3866	Pectate lyase
Amir_1845	COG0395	ABC-type sugar transport system, permease component
Amir_1847	COG4948	Mandelate Racemase Muconate Lactonizing
Amir_1852	COG1172	Belongs to the binding-protein-dependent transport system permease family
Amir_1853	COG1172	Belongs to the binding-protein-dependent transport system permease family
Amir_1855	COG1879	ABC-type sugar transport system periplasmic component
Amir_1858	COG3940	Belongs to the glycosyl hydrolase 43 family
Amir_1860	COG1609	Transcriptional regulator
Amir_1863	COG2160	L-arabinose isomerase activity
Amir_1864	COG4213	ABC transporter substrate-binding protein
Amir_1866	COG4214	carbohydrate transport
Amir_1868	COG3401	FG-GAP repeat protein
Amir_1871	COG1609	Transcriptional regulator
Amir_1877	COG2356	endonuclease I
Amir_1879	COG4585	Histidine kinase
Amir_1883	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Amir_1884	COG4715	Zinc finger, swim domain protein
Amir_1885	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Amir_1886	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Amir_1887	COG0714	Associated with various cellular activities
Amir_1888	COG3831	ATPase activity
Amir_1889	COG3831	ATPase activity
Amir_1890	COG3831	ATPase activity
Amir_1891	COG0438	transferase activity, transferring glycosyl groups
Amir_1896	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Amir_1899	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Amir_1900	COG2326	polyphosphate kinase activity
Amir_1901	COG2261	transglycosylase associated protein
Amir_1918	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Amir_1919	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Amir_1920	COG0515	serine threonine protein kinase
Amir_1920	COG2815	serine threonine protein kinase
Amir_1922	COG2755	lipolytic protein G-D-S-L family
Amir_1922	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Amir_1924	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Amir_1929	COG0395	ABC-type sugar transport system, permease component
Amir_1931	COG0702	epimerase
Amir_1933	COG0745	RESPONSE REGULATOR receiver
Amir_1937	COG2197	response regulator
Amir_1938	COG4585	Histidine kinase
Amir_1940	COG1131	(ABC) transporter
Amir_1953	COG0477	Major facilitator Superfamily
Amir_1961	COG2124	cytochrome p450
Amir_1962	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Amir_1966	COG1846	Transcriptional regulator
Amir_1970	COG2197	response regulator
Amir_1974	COG2264	protein methyltransferase activity
Amir_1980	COG0395	ABC-type sugar transport system, permease component
Amir_1981	COG4209	transmembrane transport
Amir_1983	COG1609	Transcriptional regulator
Amir_1985	COG0542	response to heat
Amir_1991	COG1011	Hydrolase
Amir_1994	COG1295	ribonuclease BN
Amir_1996	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Amir_1997	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Amir_2000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Amir_2002	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Amir_2010	COG2197	response regulator
Amir_2013	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Amir_2016	COG1595	DNA-templated transcription, initiation
Amir_2021	COG1834	amidinotransferase
Amir_2022	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Amir_2024	COG3483	tryptophan 2,3-dioxygenase activity
Amir_2028	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amir_2031	COG1132	(ABC) transporter
Amir_2037	COG2181	nitrate reductase activity
Amir_2038	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Amir_2039	COG1140	nitrate reductase beta subunit
Amir_2048	COG5297	Belongs to the glycosyl hydrolase family 6
Amir_2049	COG1732	Glycine betaine
Amir_2050	COG1174	glycine betaine transport
Amir_2051	COG0517	IMP dehydrogenase activity
Amir_2051	COG1125	glycine betaine transport
Amir_2052	COG1174	glycine betaine transport
Amir_2057	COG3842	ATPase activity
Amir_2061	COG0590	tRNA wobble adenosine to inosine editing
Amir_2063	COG3835	regulator
Amir_2070	COG0492	ferredoxin-NADP+ reductase activity
Amir_2072	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Amir_2074	COG2340	Cysteine-rich secretory protein family
Amir_2075	COG0531	amino acid
Amir_2077	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Amir_2080	COG2186	Transcriptional regulator
Amir_2089	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Amir_2093	COG1560	Kdo2-lipid A biosynthetic process
Amir_2094	COG0438	transferase activity, transferring glycosyl groups
Amir_2095	COG1051	belongs to the nudix hydrolase family
Amir_2099	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Amir_2101	COG1953	Uracil, thiamine, allantoin
Amir_2108	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Amir_2109	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Amir_2110	COG0217	transcriptional regulatory protein
Amir_2113	COG1309	transcriptional regulator
Amir_2114	COG0477	Major facilitator Superfamily
Amir_2116	COG2124	cytochrome p450
Amir_2122	COG3572	ergothioneine biosynthetic process
Amir_2123	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Amir_2125	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Amir_2132	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Amir_2137	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Amir_2139	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_2140	COG3883	PFAM NLP P60 protein
Amir_2140	COG0791	NLP P60 protein
Amir_2143	COG0746	molybdenum cofactor guanylyltransferase activity
Amir_2144	COG0500	methyltransferase
Amir_2145	COG0714	Associated with various cellular activities
Amir_2150	COG5002	protein histidine kinase activity
Amir_2161	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Amir_2165	COG3012	SEC-C Motif Domain Protein
Amir_2167	COG4733	cellulase activity
Amir_2167	COG5297	Belongs to the glycosyl hydrolase family 6
Amir_2168	COG1472	Belongs to the glycosyl hydrolase 3 family
Amir_2171	COG4209	transmembrane transport
Amir_2172	COG0395	ABC-type sugar transport system, permease component
Amir_2175	COG1324	tolerance protein
Amir_2176	COG0789	Transcriptional regulator
Amir_2179	COG0277	FAD linked oxidase domain protein
Amir_2179	COG0247	lactate metabolic process
Amir_2181	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Amir_2185	COG4221	oxidoreductase activity
Amir_2191	COG5297	Belongs to the glycosyl hydrolase family 6
Amir_2192	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Amir_2198	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Amir_2201	COG0215	cysteine-tRNA ligase activity
Amir_2207	COG0745	RESPONSE REGULATOR receiver
Amir_2208	COG0745	RESPONSE REGULATOR receiver
Amir_2209	COG5002	protein histidine kinase activity
Amir_2211	COG0646	methionine synthase
Amir_2211	COG1410	methionine synthase
Amir_2212	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Amir_2215	COG1902	pentaerythritol trinitrate reductase activity
Amir_2215	COG0446	pyridine nucleotide-disulphide oxidoreductase
Amir_2216	COG0300	oxidoreductase activity
Amir_2218	COG0140	phosphoribosyl-ATP diphosphatase activity
Amir_2219	COG0679	Auxin Efflux Carrier
Amir_2223	COG1994	Peptidase M50
Amir_2223	COG0517	IMP dehydrogenase activity
Amir_2225	COG2197	response regulator
Amir_2231	COG1222	aaa ATPase
Amir_2232	COG2197	response regulator
Amir_2233	COG4585	Histidine kinase
Amir_2241	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Amir_2242	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Amir_2243	COG4221	oxidoreductase activity
Amir_2247	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Amir_2250	COG2378	regulation of single-species biofilm formation
Amir_2251	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Amir_2256	COG4552	Acetyltransferase involved in intracellular survival and related
Amir_2262	COG3706	GGDEF domain
Amir_2268	COG2357	RelA SpoT domain protein
Amir_2272	COG1846	Transcriptional regulator
Amir_2273	COG0714	Associated with various cellular activities
Amir_2275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Amir_2277	COG1703	isobutyryl-CoA mutase activity
Amir_2277	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Amir_2277	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Amir_2280	COG0187	DNA topoisomerase II activity
Amir_2286	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Amir_2287	COG1716	ATPase activity
Amir_2287	COG5001	Diguanylate cyclase
Amir_2291	COG3845	ABC transporter
Amir_2298	COG1940	carbohydrate kinase activity
Amir_2299	COG0673	inositol 2-dehydrogenase activity
Amir_2301	COG0277	FAD linked oxidase domain protein
Amir_2310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Amir_2311	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_2312	COG2205	protein histidine kinase activity
Amir_2315	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Amir_2317	COG0745	RESPONSE REGULATOR receiver
Amir_2319	COG0745	RESPONSE REGULATOR receiver
Amir_2321	COG2201	protein-glutamate methylesterase activity
Amir_2324	COG0835	chemotaxis
Amir_2325	COG0643	Histidine kinase
Amir_2325	COG2198	Histidine kinase
Amir_2328	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Amir_2330	COG1987	bacterial-type flagellum assembly
Amir_2331	COG1338	Plays a role in the flagellum-specific transport system
Amir_2336	COG1360	Flagellar Motor Protein
Amir_2337	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Amir_2339	COG4786	Flagellar basal body rod
Amir_2342	COG0741	lytic transglycosylase activity
Amir_2344	COG1157	protein secretion by the type III secretion system
Amir_2346	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Amir_2347	COG1766	The M ring may be actively involved in energy transduction
Amir_2348	COG1677	Flagellar hook-basal body complex protein FliE
Amir_2349	COG1558	bacterial-type flagellum-dependent cell motility
Amir_2352	COG1516	flagellar protein fliS
Amir_2357	COG1256	bacterial-type flagellum assembly
Amir_2357	COG4786	Flagellar basal body rod
Amir_2359	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Amir_2360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Amir_2366	COG5002	protein histidine kinase activity
Amir_2368	COG0745	RESPONSE REGULATOR receiver
Amir_2368	COG4191	Histidine kinase
Amir_2368	COG2205	protein histidine kinase activity
Amir_2371	COG2204	response regulator
Amir_2376	COG1846	Transcriptional regulator
Amir_2380	COG4251	negative regulation of phosphorylation
Amir_2383	COG1522	sequence-specific DNA binding
Amir_2384	COG2814	Major facilitator Superfamily
Amir_2390	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_2392	COG0326	Molecular chaperone. Has ATPase activity
Amir_2395	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_2403	COG1609	Transcriptional regulator
Amir_2405	COG1175	transmembrane transport
Amir_2406	COG0395	ABC-type sugar transport system, permease component
Amir_2409	COG2197	response regulator
Amir_2410	COG4585	Histidine kinase
Amir_2417	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Amir_2423	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_2428	COG0277	FAD linked oxidase domain protein
Amir_2438	COG0420	3'-5' exonuclease activity
Amir_2448	COG2119	membrane
Amir_2455	COG0697	spore germination
Amir_2457	COG0747	negative chemotaxis
Amir_2459	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amir_2464	COG0745	RESPONSE REGULATOR receiver
Amir_2465	COG2205	protein histidine kinase activity
Amir_2469	COG1802	Transcriptional regulator
Amir_2477	COG1335	isochorismatase
Amir_2491	COG2124	cytochrome p450
Amir_2497	COG1819	glycosyl
Amir_2498	COG1132	(ABC) transporter
Amir_2503	COG3795	YCII-related domain
Amir_2504	COG4941	Belongs to the sigma-70 factor family
Amir_2511	COG0714	Associated with various cellular activities
Amir_2512	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Amir_2519	COG0384	phenazine biosynthesis protein PhzF
Amir_2522	COG3629	intracellular signal transduction
Amir_2522	COG3903	Transcriptional regulator
Amir_2531	COG0515	serine threonine protein kinase
Amir_2534	COG1653	transport
Amir_2535	COG2124	cytochrome p450
Amir_2537	COG2814	Major facilitator Superfamily
Amir_2540	COG4581	dead DEAH box helicase
Amir_2548	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Amir_2551	COG0477	Major facilitator Superfamily
Amir_2553	COG1612	heme a metabolic process
Amir_2555	COG5001	Diguanylate cyclase
Amir_2573	COG0395	ABC-type sugar transport system, permease component
Amir_2577	COG1609	Transcriptional regulator
Amir_2579	COG1595	DNA-templated transcription, initiation
Amir_2594	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Amir_2596	COG0477	Major facilitator Superfamily
Amir_2608	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_2609	COG1309	transcriptional regulator
Amir_2610	COG3384	dioxygenase
Amir_2611	COG0702	epimerase
Amir_2616	COG0488	(ABC) transporter
Amir_2619	COG0640	Transcriptional regulator
Amir_2620	COG0346	lactoylglutathione lyase activity
Amir_2625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_2627	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amir_2631	COG2205	protein histidine kinase activity
Amir_2633	COG1253	flavin adenine dinucleotide binding
Amir_2635	COG0604	alcohol dehydrogenase
Amir_2637	COG2080	2 iron, 2 sulfur cluster binding
Amir_2637	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Amir_2645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amir_2647	COG2376	Dihydroxyacetone kinase
Amir_2648	COG0698	ribose 5-phosphate isomerase
Amir_2649	COG0149	triose-phosphate isomerase activity
Amir_2650	COG1082	Xylose isomerase domain protein TIM barrel
Amir_2651	COG2084	Dehydrogenase
Amir_2655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Amir_2662	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amir_2662	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amir_2664	COG1834	amidinotransferase
Amir_2667	COG0475	glutathione-regulated potassium exporter activity
Amir_2668	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Amir_2676	COG1131	(ABC) transporter
Amir_2680	COG0477	Major facilitator Superfamily
Amir_2685	COG2267	carboxylic ester hydrolase activity
Amir_2688	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Amir_2692	COG1509	lysine 2,3-aminomutase activity
Amir_2697	COG1136	(ABC) transporter
Amir_2707	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_2708	COG1120	ATPase activity
Amir_2717	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Amir_2720	COG1120	ATPase activity
Amir_2721	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_2722	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_2723	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Amir_2724	COG2375	cellular response to nickel ion
Amir_2726	COG1021	2,3-dihydroxybenzoate-AMP ligase
Amir_2727	COG1169	isochorismate synthase
Amir_2728	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_2730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_2731	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Amir_2733	COG3655	Transcriptional regulator
Amir_2736	COG4585	Histidine kinase
Amir_2737	COG2197	response regulator
Amir_2739	COG0148	phosphopyruvate hydratase activity
Amir_2742	COG4152	abc transporter atp-binding protein
Amir_2743	COG1668	transmembrane transport
Amir_2754	COG0477	Major facilitator Superfamily
Amir_2756	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Amir_2757	COG2197	response regulator
Amir_2759	COG1136	(ABC) transporter
Amir_2759	COG0577	efflux transmembrane transporter activity
Amir_2775	COG0456	acetyltransferase
Amir_2776	COG1309	transcriptional regulator
Amir_2777	COG1132	(ABC) transporter
Amir_2780	COG0738	Major facilitator superfamily
Amir_2782	COG0583	DNA-binding transcription factor activity
Amir_2783	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Amir_2785	COG1012	belongs to the aldehyde dehydrogenase family
Amir_2790	COG2409	Drug exporters of the RND superfamily
Amir_2811	COG2197	response regulator
Amir_2820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Amir_2821	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Amir_2824	COG1131	(ABC) transporter
Amir_2826	COG0604	alcohol dehydrogenase
Amir_2826	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_2826	COG3321	synthase
Amir_2832	COG1653	transport
Amir_2834	COG3833	ABC-type maltose transport systems, permease component
Amir_2837	COG3507	Belongs to the glycosyl hydrolase 43 family
Amir_2839	COG0596	Alpha beta hydrolase
Amir_2842	COG2197	response regulator
Amir_2846	COG0028	Belongs to the TPP enzyme family
Amir_2847	COG1473	amidohydrolase
Amir_2848	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_2851	COG1177	transmembrane transport
Amir_2852	COG1176	ABC-type spermidine putrescine transport system, permease component I
Amir_2853	COG3842	ATPase activity
Amir_2855	COG4221	oxidoreductase activity
Amir_2859	COG1309	transcriptional regulator
Amir_2870	COG3209	COG3209 Rhs family protein
Amir_2874	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_2875	COG1120	ATPase activity
Amir_2882	COG0135	phosphoribosylanthranilate isomerase activity
Amir_2887	COG2076	Multidrug Resistance protein
Amir_2897	COG0642	Histidine kinase
Amir_2900	COG1309	transcriptional regulator
Amir_2909	COG3831	ATPase activity
Amir_2910	COG4251	negative regulation of phosphorylation
Amir_2912	COG0784	Response regulator, receiver
Amir_2915	COG1733	regulation of RNA biosynthetic process
Amir_2916	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_2918	COG0395	ABC-type sugar transport system, permease component
Amir_2922	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Amir_2925	COG3903	Transcriptional regulator
Amir_2925	COG3629	intracellular signal transduction
Amir_2933	COG1222	aaa ATPase
Amir_2954	COG3629	intracellular signal transduction
Amir_2954	COG3903	Transcriptional regulator
Amir_2964	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Amir_2966	COG3831	ATPase activity
Amir_2967	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Amir_2973	COG0673	inositol 2-dehydrogenase activity
Amir_2976	COG0494	nUDIX hydrolase
Amir_2977	COG1309	transcriptional regulator
Amir_2984	COG1175	transmembrane transport
Amir_2986	COG1501	Belongs to the glycosyl hydrolase 31 family
Amir_2988	COG1609	Transcriptional regulator
Amir_2993	COG4106	trans-aconitate 2-methyltransferase activity
Amir_2997	COG2318	DinB family
Amir_2998	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Amir_3001	COG1309	transcriptional regulator
Amir_3003	COG0789	Transcriptional regulator
Amir_3004	COG2197	response regulator
Amir_3006	COG1136	(ABC) transporter
Amir_3006	COG0577	efflux transmembrane transporter activity
Amir_3007	COG1136	(ABC) transporter
Amir_3007	COG0577	efflux transmembrane transporter activity
Amir_3016	COG2375	cellular response to nickel ion
Amir_3021	COG3831	ATPase activity
Amir_3024	COG0483	inositol monophosphate 1-phosphatase activity
Amir_3025	COG1132	(ABC) transporter
Amir_3026	COG1132	(ABC) transporter
Amir_3036	COG1556	Lactate utilization protein
Amir_3037	COG1139	Iron-sulfur cluster binding protein
Amir_3038	COG0247	lactate metabolic process
Amir_3039	COG2188	Transcriptional regulator
Amir_3041	COG1129	ABC transporter
Amir_3043	COG1172	Belongs to the binding-protein-dependent transport system permease family
Amir_3046	COG3347	Dehydrogenase
Amir_3046	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3047	COG1070	Carbohydrate kinase
Amir_3049	COG0402	S-adenosylhomocysteine deaminase activity
Amir_3051	COG0583	DNA-binding transcription factor activity
Amir_3054	COG3851	Histidine kinase
Amir_3056	COG1595	DNA-templated transcription, initiation
Amir_3059	COG2124	cytochrome p450
Amir_3067	COG0601	transmembrane transport
Amir_3068	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amir_3069	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Amir_3071	COG0367	asparagine synthase
Amir_3075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Amir_3077	COG1012	belongs to the aldehyde dehydrogenase family
Amir_3078	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Amir_3086	COG3293	Transposase
Amir_3090	COG0583	DNA-binding transcription factor activity
Amir_3093	COG2814	Major facilitator Superfamily
Amir_3102	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Amir_3103	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Amir_3106	COG3345	alpha-galactosidase
Amir_3109	COG0644	oxidoreductase
Amir_3110	COG0156	8-amino-7-oxononanoate synthase activity
Amir_3118	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Amir_3119	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_3128	COG0583	DNA-binding transcription factor activity
Amir_3131	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amir_3133	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Amir_3134	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Amir_3139	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3141	COG1830	Aldolase
Amir_3142	COG1063	alcohol dehydrogenase
Amir_3144	COG0659	secondary active sulfate transmembrane transporter activity
Amir_3152	COG1408	metallophosphoesterase
Amir_3157	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Amir_3157	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Amir_3158	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Amir_3160	COG2856	Zn peptidase
Amir_3162	COG2409	Drug exporters of the RND superfamily
Amir_3165	COG1024	Enoyl-CoA hydratase
Amir_3172	COG1309	transcriptional regulator
Amir_3174	COG1132	(ABC) transporter
Amir_3175	COG0475	glutathione-regulated potassium exporter activity
Amir_3182	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Amir_3185	COG1250	3-hydroxyacyl-CoA dehydrogenase
Amir_3186	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amir_3192	COG3795	YCII-related domain
Amir_3195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Amir_3200	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3213	COG3507	Belongs to the glycosyl hydrolase 43 family
Amir_3218	COG4585	Histidine kinase
Amir_3219	COG2197	response regulator
Amir_3225	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3226	COG0667	Aldo Keto reductase
Amir_3230	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Amir_3231	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Amir_3244	COG1388	LysM domain
Amir_3279	COG1250	3-hydroxyacyl-CoA dehydrogenase
Amir_3286	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Amir_3289	COG0546	phosphoglycolate phosphatase activity
Amir_3290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Amir_3301	COG3693	PFAM glycoside hydrolase, family 10
Amir_3301	COG3509	depolymerase
Amir_3304	COG1609	Transcriptional regulator
Amir_3307	COG1335	isochorismatase
Amir_3311	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3314	COG2197	response regulator
Amir_3315	COG4585	Histidine kinase
Amir_3318	COG1073	alpha beta
Amir_3321	COG0714	Associated with various cellular activities
Amir_3334	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3338	COG1609	Transcriptional regulator
Amir_3340	COG1733	regulation of RNA biosynthetic process
Amir_3345	COG2267	carboxylic ester hydrolase activity
Amir_3351	COG2261	transglycosylase associated protein
Amir_3353	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Amir_3359	COG1064	alcohol dehydrogenase
Amir_3362	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Amir_3365	COG0667	Aldo Keto reductase
Amir_3368	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Amir_3369	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Amir_3376	COG0028	Belongs to the TPP enzyme family
Amir_3380	COG0583	DNA-binding transcription factor activity
Amir_3383	COG1233	COG1233 Phytoene dehydrogenase and related
Amir_3388	COG2249	NAD(P)H dehydrogenase (quinone) activity
Amir_3394	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Amir_3395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Amir_3397	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Amir_3398	COG1607	acyl-coa hydrolase
Amir_3402	COG0463	Glycosyl transferase, family 2
Amir_3408	COG1435	thymidine kinase activity
Amir_3411	COG2270	Major facilitator Superfamily
Amir_3414	COG3706	GGDEF domain
Amir_3417	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Amir_3423	COG0640	Transcriptional regulator
Amir_3424	COG0798	PFAM Bile acid sodium symporter
Amir_3437	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3441	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Amir_3442	COG1349	DNA-binding transcription factor activity
Amir_3443	COG0494	nUDIX hydrolase
Amir_3445	COG2176	DNA-directed DNA polymerase activity
Amir_3445	COG5002	protein histidine kinase activity
Amir_3454	COG1619	proteins homologs of microcin C7 resistance protein MccF
Amir_3461	COG1960	acyl-CoA dehydrogenase activity
Amir_3464	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amir_3466	COG0747	negative chemotaxis
Amir_3467	COG2362	D-Aminopeptidase
Amir_3468	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amir_3470	COG1609	Transcriptional regulator
Amir_3473	COG1175	transmembrane transport
Amir_3475	COG4974	Belongs to the 'phage' integrase family
Amir_3487	COG0667	Aldo Keto reductase
Amir_3495	COG2755	lipolytic protein G-D-S-L family
Amir_3502	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Amir_3504	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Amir_3506	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Amir_3508	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amir_3511	COG1846	Transcriptional regulator
Amir_3516	COG2130	NADP-dependent
Amir_3518	COG1643	Atp-dependent helicase
Amir_3522	COG1968	undecaprenyl-diphosphatase activity
Amir_3523	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_3524	COG0667	Aldo Keto reductase
Amir_3531	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Amir_3533	COG2909	trisaccharide binding
Amir_3534	COG1414	Transcriptional regulator
Amir_3536	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Amir_3547	COG2814	Major facilitator Superfamily
Amir_3553	COG1216	Glycosyl transferase, family 2
Amir_3553	COG0438	transferase activity, transferring glycosyl groups
Amir_3559	COG1316	TRANSCRIPTIONal
Amir_3561	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_3565	COG1309	transcriptional regulator
Amir_3568	COG4552	Acetyltransferase involved in intracellular survival and related
Amir_3569	COG3507	Belongs to the glycosyl hydrolase 43 family
Amir_3571	COG3903	Transcriptional regulator
Amir_3571	COG3629	intracellular signal transduction
Amir_3574	COG2197	response regulator
Amir_3576	COG2124	cytochrome p450
Amir_3581	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Amir_3582	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Amir_3589	COG0310	cobalt ion transport
Amir_3595	COG2508	Transcriptional regulator
Amir_3595	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Amir_3596	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Amir_3597	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Amir_3600	COG2124	cytochrome p450
Amir_3603	COG1132	(ABC) transporter
Amir_3612	COG1136	(ABC) transporter
Amir_3617	COG1012	belongs to the aldehyde dehydrogenase family
Amir_3624	COG0110	maltose O-acetyltransferase activity
Amir_3630	COG2226	methyltransferase
Amir_3645	COG1674	ftsk spoiiie
Amir_3654	COG0667	Aldo Keto reductase
Amir_3663	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amir_3667	COG1132	(ABC) transporter
Amir_3670	COG2192	nodulation
Amir_3676	COG0367	asparagine synthase
Amir_3685	COG2366	antibiotic biosynthetic process
Amir_3687	COG1733	regulation of RNA biosynthetic process
Amir_3695	COG1132	(ABC) transporter
Amir_3705	COG3290	protein histidine kinase activity
Amir_3709	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_3711	COG1309	transcriptional regulator
Amir_3715	COG3030	protein affecting phage T7 exclusion by the F plasmid
Amir_3724	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Amir_3730	COG3395	kinase activity
Amir_3731	COG0235	Class ii aldolase
Amir_3732	COG1349	DNA-binding transcription factor activity
Amir_3735	COG0387	Pfam Sodium calcium exchanger
Amir_3737	COG3629	intracellular signal transduction
Amir_3737	COG3903	Transcriptional regulator
Amir_3740	COG2205	protein histidine kinase activity
Amir_3740	COG2198	Histidine kinase
Amir_3740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amir_3740	COG0784	Response regulator, receiver
Amir_3742	COG2172	sigma factor antagonist activity
Amir_3743	COG1366	Belongs to the anti-sigma-factor antagonist family
Amir_3744	COG1366	Belongs to the anti-sigma-factor antagonist family
Amir_3747	COG2072	flavoprotein involved in K transport
Amir_3763	COG0789	Transcriptional regulator
Amir_3768	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amir_3796	COG3345	alpha-galactosidase
Amir_3799	COG1733	regulation of RNA biosynthetic process
Amir_3800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Amir_3801	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Amir_3804	COG1959	2 iron, 2 sulfur cluster binding
Amir_3805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Amir_3805	COG1017	nitric oxide dioxygenase activity
Amir_3814	COG4106	trans-aconitate 2-methyltransferase activity
Amir_3819	COG0667	Aldo Keto reductase
Amir_3826	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Amir_3827	COG1021	2,3-dihydroxybenzoate-AMP ligase
Amir_3829	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Amir_3830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Amir_3833	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Amir_3838	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amir_3840	COG0673	inositol 2-dehydrogenase activity
Amir_3846	COG1309	transcriptional regulator
Amir_3849	COG3537	Alpha-1,2-mannosidase
Amir_3851	COG0596	Alpha beta hydrolase
Amir_3856	COG2814	Major facilitator Superfamily
Amir_3857	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Amir_3869	COG2755	lipolytic protein G-D-S-L family
Amir_3871	COG0745	RESPONSE REGULATOR receiver
Amir_3873	COG4974	Belongs to the 'phage' integrase family
Amir_3892	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3892	COG3321	synthase
Amir_3892	COG0300	oxidoreductase activity
Amir_3892	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Amir_3892	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_3900	COG0583	DNA-binding transcription factor activity
Amir_3911	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_3914	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Amir_3915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_3924	COG2192	nodulation
Amir_3926	COG3940	Belongs to the glycosyl hydrolase 43 family
Amir_3931	COG0667	Aldo Keto reductase
Amir_3933	COG2192	nodulation
Amir_3938	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Amir_3947	COG2197	response regulator
Amir_3949	COG1309	transcriptional regulator
Amir_3958	COG3866	Pectate lyase
Amir_3959	COG3509	depolymerase
Amir_3964	COG1064	alcohol dehydrogenase
Amir_3974	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Amir_3975	COG1309	transcriptional regulator
Amir_3976	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3979	COG3226	Transcriptional regulator
Amir_3980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Amir_3983	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amir_3986	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3988	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_3989	COG0435	Glutathione S-transferase
Amir_3994	COG0596	Alpha beta hydrolase
Amir_3995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Amir_4000	COG3851	Histidine kinase
Amir_4001	COG2197	response regulator
Amir_4009	COG0673	inositol 2-dehydrogenase activity
Amir_4012	COG4335	DNA alkylation repair
Amir_4013	COG0596	Alpha beta hydrolase
Amir_4014	COG0745	RESPONSE REGULATOR receiver
Amir_4015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Amir_4028	COG0515	serine threonine protein kinase
Amir_4033	COG0492	ferredoxin-NADP+ reductase activity
Amir_4036	COG0475	glutathione-regulated potassium exporter activity
Amir_4049	COG1136	(ABC) transporter
Amir_4051	COG2197	response regulator
Amir_4052	COG3851	Histidine kinase
Amir_4068	COG5002	protein histidine kinase activity
Amir_4069	COG0745	RESPONSE REGULATOR receiver
Amir_4071	COG0577	efflux transmembrane transporter activity
Amir_4071	COG1136	(ABC) transporter
Amir_4072	COG0577	efflux transmembrane transporter activity
Amir_4077	COG2345	Transcriptional regulator
Amir_4084	COG1960	acyl-CoA dehydrogenase activity
Amir_4086	COG2814	Major facilitator Superfamily
Amir_4092	COG0596	Alpha beta hydrolase
Amir_4097	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Amir_4099	COG0300	oxidoreductase activity
Amir_4102	COG2124	cytochrome p450
Amir_4104	COG2207	Transcriptional regulator
Amir_4115	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_4116	COG1024	Enoyl-CoA hydratase
Amir_4119	COG4977	sequence-specific DNA binding
Amir_4119	COG1917	Cupin 2, conserved barrel domain protein
Amir_4128	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Amir_4130	COG1609	Transcriptional regulator
Amir_4132	COG4948	Mandelate Racemase Muconate Lactonizing
Amir_4137	COG2205	protein histidine kinase activity
Amir_4138	COG0745	RESPONSE REGULATOR receiver
Amir_4148	COG2267	carboxylic ester hydrolase activity
Amir_4158	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Amir_4160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Amir_4164	COG1414	Transcriptional regulator
Amir_4165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Amir_4166	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Amir_4173	COG3340	Belongs to the peptidase S51 family
Amir_4182	COG3629	intracellular signal transduction
Amir_4182	COG3903	Transcriptional regulator
Amir_4183	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Amir_4185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Amir_4191	COG0840	transmembrane signaling receptor activity
Amir_4193	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Amir_4194	COG1404	Belongs to the peptidase S8 family
Amir_4195	COG1404	Belongs to the peptidase S8 family
Amir_4196	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Amir_4196	COG3266	domain, Protein
Amir_4196	COG4932	domain protein
Amir_4203	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Amir_4204	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Amir_4206	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Amir_4208	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amir_4208	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amir_4210	COG0697	spore germination
Amir_4211	COG0644	oxidoreductase
Amir_4215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Amir_4225	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Amir_4228	COG0659	secondary active sulfate transmembrane transporter activity
Amir_4233	COG3467	pyridoxamine 5'-phosphate
Amir_4234	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Amir_4235	COG2124	cytochrome p450
Amir_4237	COG0726	polysaccharide deacetylase
Amir_4238	COG0439	Biotin carboxylase
Amir_4239	COG0395	ABC-type sugar transport system, permease component
Amir_4240	COG1175	transmembrane transport
Amir_4241	COG2182	Extracellular solute-binding protein
Amir_4243	COG0667	Aldo Keto reductase
Amir_4247	COG0300	oxidoreductase activity
Amir_4253	COG0110	maltose O-acetyltransferase activity
Amir_4256	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amir_4259	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Amir_4260	COG2197	response regulator
Amir_4261	COG3850	Histidine kinase
Amir_4265	COG3831	ATPase activity
Amir_4277	COG1902	pentaerythritol trinitrate reductase activity
Amir_4283	COG0640	Transcriptional regulator
Amir_4286	COG0640	Transcriptional regulator
Amir_4287	COG0672	)-iron permease
Amir_4289	COG2837	iron assimilation
Amir_4292	COG0596	Alpha beta hydrolase
Amir_4293	COG1120	ATPase activity
Amir_4294	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_4295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_4300	COG1982	Orn Lys Arg decarboxylase major
Amir_4307	COG0277	FAD linked oxidase domain protein
Amir_4311	COG0583	DNA-binding transcription factor activity
Amir_4312	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_4313	COG1960	acyl-CoA dehydrogenase activity
Amir_4322	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Amir_4323	COG4172	Belongs to the ABC transporter superfamily
Amir_4332	COG0784	Response regulator, receiver
Amir_4335	COG1522	sequence-specific DNA binding
Amir_4337	COG0861	Integral membrane protein TerC family
Amir_4338	COG1309	transcriptional regulator
Amir_4340	COG2807	transmembrane transport
Amir_4342	COG0475	glutathione-regulated potassium exporter activity
Amir_4345	COG2814	Major facilitator Superfamily
Amir_4351	COG0745	RESPONSE REGULATOR receiver
Amir_4353	COG2986	histidine ammonia-lyase
Amir_4368	COG1960	acyl-CoA dehydrogenase activity
Amir_4371	COG0183	Belongs to the thiolase family
Amir_4372	COG1250	3-hydroxyacyl-CoA dehydrogenase
Amir_4372	COG1024	Enoyl-CoA hydratase
Amir_4373	COG1309	transcriptional regulator
Amir_4376	COG2010	Cytochrome c
Amir_4376	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Amir_4377	COG2080	2 iron, 2 sulfur cluster binding
Amir_4379	COG0142	geranyltranstransferase activity
Amir_4380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Amir_4381	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Amir_4383	COG2175	clavaminate synthase activity
Amir_4386	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Amir_4392	COG2340	Cysteine-rich secretory protein family
Amir_4395	COG1309	transcriptional regulator
Amir_4398	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_4399	COG1309	transcriptional regulator
Amir_4400	COG0789	Transcriptional regulator
Amir_4404	COG3831	ATPase activity
Amir_4408	COG0438	transferase activity, transferring glycosyl groups
Amir_4415	COG0254	rRNA binding
Amir_4417	COG0753	catalase activity
Amir_4418	COG0519	Catalyzes the synthesis of GMP from XMP
Amir_4418	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Amir_4419	COG2258	MOSC domain
Amir_4423	COG0604	alcohol dehydrogenase
Amir_4425	COG0604	alcohol dehydrogenase
Amir_4433	COG2197	response regulator
Amir_4434	COG4585	Histidine kinase
Amir_4437	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Amir_4438	COG1121	(ABC) transporter
Amir_4439	COG0803	Belongs to the bacterial solute-binding protein 9 family
Amir_4440	COG0604	alcohol dehydrogenase
Amir_4440	COG3321	synthase
Amir_4445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Amir_4451	COG3629	intracellular signal transduction
Amir_4456	COG0730	response to heat
Amir_4459	COG4221	oxidoreductase activity
Amir_4468	COG1022	Amp-dependent synthetase and ligase
Amir_4472	COG1309	transcriptional regulator
Amir_4473	COG0778	Nitroreductase
Amir_4479	COG1063	alcohol dehydrogenase
Amir_4485	COG1509	lysine 2,3-aminomutase activity
Amir_4487	COG0644	oxidoreductase
Amir_4488	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Amir_4489	COG2808	Putative FMN-binding domain
Amir_4499	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Amir_4500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Amir_4501	COG0165	Argininosuccinate lyase
Amir_4508	COG3973	AAA domain
Amir_4509	COG2409	Drug exporters of the RND superfamily
Amir_4511	COG2197	response regulator
Amir_4513	COG2205	protein histidine kinase activity
Amir_4514	COG0745	RESPONSE REGULATOR receiver
Amir_4536	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amir_4573	COG0546	phosphoglycolate phosphatase activity
Amir_4588	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Amir_4589	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Amir_4597	COG3903	Transcriptional regulator
Amir_4597	COG3629	intracellular signal transduction
Amir_4599	COG2124	cytochrome p450
Amir_4603	COG0300	oxidoreductase activity
Amir_4606	COG2272	Belongs to the type-B carboxylesterase lipase family
Amir_4608	COG1609	Transcriptional regulator
Amir_4610	COG1175	transmembrane transport
Amir_4619	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_4620	COG1309	transcriptional regulator
Amir_4622	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_4628	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Amir_4632	COG0583	DNA-binding transcription factor activity
Amir_4633	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Amir_4634	COG3250	beta-galactosidase activity
Amir_4636	COG2909	trisaccharide binding
Amir_4642	COG0438	transferase activity, transferring glycosyl groups
Amir_4650	COG1022	Amp-dependent synthetase and ligase
Amir_4653	COG0508	dehydrogenase complex catalyzes the overall conversion of
Amir_4653	COG0022	dehydrogenase e1 component
Amir_4654	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Amir_4658	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_4664	COG2755	lipolytic protein G-D-S-L family
Amir_4666	COG2197	response regulator
Amir_4671	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_4683	COG1309	transcriptional regulator
Amir_4684	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_4685	COG1012	belongs to the aldehyde dehydrogenase family
Amir_4698	COG3321	synthase
Amir_4698	COG0604	alcohol dehydrogenase
Amir_4702	COG0702	epimerase
Amir_4705	COG1733	regulation of RNA biosynthetic process
Amir_4713	COG0006	proline dipeptidase activity
Amir_4716	COG0444	Belongs to the ABC transporter superfamily
Amir_4719	COG0747	negative chemotaxis
Amir_4720	COG1802	Transcriptional regulator
Amir_4722	COG3938	Belongs to the proline racemase family
Amir_4723	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amir_4726	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Amir_4728	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Amir_4729	COG1609	Transcriptional regulator
Amir_4731	COG0402	S-adenosylhomocysteine deaminase activity
Amir_4743	COG1131	(ABC) transporter
Amir_4745	COG1595	DNA-templated transcription, initiation
Amir_4747	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Amir_4749	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Amir_4761	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Amir_4770	COG1121	(ABC) transporter
Amir_4771	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Amir_4773	COG0523	cobalamin synthesis protein
Amir_4783	COG1120	ATPase activity
Amir_4784	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_4789	COG0840	transmembrane signaling receptor activity
Amir_4791	COG0583	DNA-binding transcription factor activity
Amir_4792	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_4794	COG1309	transcriptional regulator
Amir_4795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Amir_4796	COG2391	methyltransferase activity
Amir_4802	COG0477	Major facilitator Superfamily
Amir_4803	COG1309	transcriptional regulator
Amir_4815	COG2018	Roadblock/LC7 domain
Amir_4818	COG0673	inositol 2-dehydrogenase activity
Amir_4821	COG1929	Belongs to the glycerate kinase type-1 family
Amir_4825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Amir_4834	COG2124	cytochrome p450
Amir_4836	COG1216	Glycosyl transferase, family 2
Amir_4838	COG0702	epimerase
Amir_4841	COG1819	glycosyl
Amir_4844	COG1819	glycosyl
Amir_4848	COG0515	serine threonine protein kinase
Amir_4851	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Amir_4852	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_4856	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amir_4856	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_4857	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Amir_4858	COG1012	belongs to the aldehyde dehydrogenase family
Amir_4860	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_4861	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Amir_4862	COG1132	(ABC) transporter
Amir_4863	COG1309	transcriptional regulator
Amir_4866	COG3386	PFAM SMP-30 Gluconolaconase
Amir_4867	COG2072	flavoprotein involved in K transport
Amir_4879	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Amir_4880	COG0494	nUDIX hydrolase
Amir_4882	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amir_4884	COG1414	Transcriptional regulator
Amir_4885	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Amir_4887	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amir_4889	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amir_4891	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Amir_4893	COG0583	DNA-binding transcription factor activity
Amir_4896	COG1902	pentaerythritol trinitrate reductase activity
Amir_4903	COG1802	Transcriptional regulator
Amir_4905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_4906	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_4909	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Amir_4910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_4912	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_4918	COG2022	thiamine diphosphate biosynthetic process
Amir_4921	COG2770	Histidine kinase
Amir_4921	COG2208	phosphoserine phosphatase activity
Amir_4923	COG2365	Tyrosine phosphatase family
Amir_4925	COG2755	lipolytic protein G-D-S-L family
Amir_4926	COG3835	regulator
Amir_4932	COG1929	Belongs to the glycerate kinase type-1 family
Amir_4934	COG2205	protein histidine kinase activity
Amir_4938	COG0477	Major facilitator Superfamily
Amir_4940	COG0583	DNA-binding transcription factor activity
Amir_4943	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Amir_4947	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Amir_4956	COG0463	Glycosyl transferase, family 2
Amir_4958	COG0438	transferase activity, transferring glycosyl groups
Amir_4963	COG1472	Belongs to the glycosyl hydrolase 3 family
Amir_4966	COG3693	PFAM glycoside hydrolase, family 10
Amir_4970	COG0500	methyltransferase
Amir_4975	COG2409	Drug exporters of the RND superfamily
Amir_4979	COG1253	flavin adenine dinucleotide binding
Amir_4990	COG0009	L-threonylcarbamoyladenylate synthase
Amir_4995	COG2197	response regulator
Amir_5000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Amir_5001	COG0508	dehydrogenase complex catalyzes the overall conversion of
Amir_5004	COG1522	sequence-specific DNA binding
Amir_5005	COG2340	Cysteine-rich secretory protein family
Amir_5006	COG2205	protein histidine kinase activity
Amir_5016	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Amir_5017	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Amir_5025	COG0463	Glycosyl transferase, family 2
Amir_5027	COG1064	alcohol dehydrogenase
Amir_5028	COG1309	transcriptional regulator
Amir_5030	COG2855	membrane
Amir_5033	COG0745	RESPONSE REGULATOR receiver
Amir_5034	COG4251	negative regulation of phosphorylation
Amir_5035	COG0784	Response regulator, receiver
Amir_5043	COG3973	AAA domain
Amir_5046	COG1309	transcriptional regulator
Amir_5047	COG0300	oxidoreductase activity
Amir_5049	COG0823	Involved in the tonB-independent uptake of proteins
Amir_5052	COG3973	AAA domain
Amir_5053	COG1120	ATPase activity
Amir_5054	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_5055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Amir_5057	COG1063	alcohol dehydrogenase
Amir_5058	COG0477	Major facilitator Superfamily
Amir_5059	COG0246	Mannitol dehydrogenase
Amir_5065	COG4607	ABC-type enterochelin transport system periplasmic component
Amir_5066	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Amir_5067	COG1132	(ABC) transporter
Amir_5068	COG1132	(ABC) transporter
Amir_5069	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amir_5075	COG0583	DNA-binding transcription factor activity
Amir_5080	COG1414	Transcriptional regulator
Amir_5081	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Amir_5083	COG2267	carboxylic ester hydrolase activity
Amir_5084	COG3485	protocatechuate 3,4-dioxygenase
Amir_5085	COG3485	protocatechuate 3,4-dioxygenase
Amir_5086	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Amir_5087	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Amir_5090	COG2208	phosphoserine phosphatase activity
Amir_5090	COG2770	Histidine kinase
Amir_5091	COG0784	Response regulator, receiver
Amir_5091	COG5002	protein histidine kinase activity
Amir_5094	COG0248	Ppx GppA phosphatase
Amir_5098	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_5102	COG1609	Transcriptional regulator
Amir_5103	COG1619	proteins homologs of microcin C7 resistance protein MccF
Amir_5104	COG0300	oxidoreductase activity
Amir_5105	COG1309	transcriptional regulator
Amir_5117	COG1609	Transcriptional regulator
Amir_5120	COG0739	heme binding
Amir_5121	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Amir_5122	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Amir_5124	COG0596	Alpha beta hydrolase
Amir_5127	COG0583	DNA-binding transcription factor activity
Amir_5129	COG1349	DNA-binding transcription factor activity
Amir_5130	COG4821	SIS domain
Amir_5131	COG1132	(ABC) transporter
Amir_5132	COG1024	Enoyl-CoA hydratase
Amir_5134	COG0488	(ABC) transporter
Amir_5135	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_5142	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Amir_5145	COG3706	GGDEF domain
Amir_5148	COG2151	metal-sulfur cluster biosynthetic enzyme
Amir_5149	COG0822	iron-sulfur transferase activity
Amir_5151	COG0396	ATPase activity
Amir_5159	COG1752	Esterase of the alpha-beta hydrolase superfamily
Amir_5160	COG0438	transferase activity, transferring glycosyl groups
Amir_5162	COG1131	(ABC) transporter
Amir_5169	COG1510	regulation of RNA biosynthetic process
Amir_5171	COG2018	Roadblock/LC7 domain
Amir_5172	COG5002	protein histidine kinase activity
Amir_5174	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Amir_5185	COG0109	protoheme IX farnesyltransferase activity
Amir_5187	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Amir_5188	COG0166	Belongs to the GPI family
Amir_5191	COG0363	glucosamine-6-phosphate deaminase activity
Amir_5192	COG4585	Histidine kinase
Amir_5196	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Amir_5197	COG0149	triose-phosphate isomerase activity
Amir_5198	COG0126	phosphoglycerate kinase activity
Amir_5199	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Amir_5203	COG1481	regulation of sporulation
Amir_5205	COG1660	Displays ATPase and GTPase activities
Amir_5206	COG0322	excinuclease ABC activity
Amir_5215	COG2234	aminopeptidase activity
Amir_5217	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Amir_5218	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Amir_5218	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Amir_5224	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Amir_5225	COG0242	peptide deformylase activity
Amir_5232	COG0405	Gamma-glutamyltransferase
Amir_5235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Amir_5237	COG1758	RNA polymerase activity
Amir_5238	COG0194	GDP metabolic process
Amir_5240	COG0284	orotidine-5'-phosphate decarboxylase activity
Amir_5242	COG0505	Belongs to the CarA family
Amir_5245	COG0540	Belongs to the ATCase OTCase family
Amir_5246	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Amir_5248	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Amir_5249	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Amir_5250	COG0006	proline dipeptidase activity
Amir_5252	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Amir_5253	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Amir_5254	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Amir_5255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Amir_5257	COG2190	(PTS) system
Amir_5258	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Amir_5258	COG1263	PTS System
Amir_5260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Amir_5260	COG1263	PTS System
Amir_5261	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Amir_5262	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Amir_5264	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Amir_5265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Amir_5274	COG4581	dead DEAH box helicase
Amir_5276	COG1388	LysM domain
Amir_5278	COG3279	Response regulator of the LytR AlgR family
Amir_5280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Amir_5281	COG3275	phosphorelay sensor kinase activity
Amir_5290	COG1733	regulation of RNA biosynthetic process
Amir_5294	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Amir_5307	COG0395	ABC-type sugar transport system, permease component
Amir_5311	COG1024	Enoyl-CoA hydratase
Amir_5316	COG2258	MOSC domain
Amir_5317	COG0667	Aldo Keto reductase
Amir_5320	COG2030	dehydratase
Amir_5320	COG1012	belongs to the aldehyde dehydrogenase family
Amir_5323	COG3903	Transcriptional regulator
Amir_5323	COG3629	intracellular signal transduction
Amir_5324	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Amir_5324	COG2755	lipolytic protein G-D-S-L family
Amir_5326	COG1132	(ABC) transporter
Amir_5331	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Amir_5332	COG0564	pseudouridine synthase activity
Amir_5343	COG1609	Transcriptional regulator
Amir_5352	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amir_5352	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Amir_5356	COG1716	ATPase activity
Amir_5366	COG0667	Aldo Keto reductase
Amir_5375	COG2197	response regulator
Amir_5376	COG2197	response regulator
Amir_5393	COG1222	aaa ATPase
Amir_5402	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Amir_5403	COG1366	Belongs to the anti-sigma-factor antagonist family
Amir_5407	COG4977	sequence-specific DNA binding
Amir_5417	COG2018	Roadblock/LC7 domain
Amir_5419	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Amir_5421	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Amir_5421	COG1116	anion transmembrane transporter activity
Amir_5422	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amir_5423	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Amir_5425	COG1187	pseudouridine synthase activity
Amir_5426	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Amir_5427	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Amir_5430	COG0640	Transcriptional regulator
Amir_5435	COG0504	CTP synthase activity
Amir_5440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Amir_5443	COG0647	UMP catabolic process
Amir_5445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Amir_5448	COG2094	Belongs to the DNA glycosylase MPG family
Amir_5449	COG0165	Argininosuccinate lyase
Amir_5450	COG0137	argininosuccinate synthase activity
Amir_5451	COG1438	arginine binding
Amir_5454	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Amir_5455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Amir_5456	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Amir_5457	COG0604	alcohol dehydrogenase
Amir_5460	COG1476	TRANSCRIPTIONal
Amir_5464	COG0072	phenylalanine-tRNA ligase activity
Amir_5464	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Amir_5465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Amir_5466	COG0326	Molecular chaperone. Has ATPase activity
Amir_5468	COG0745	RESPONSE REGULATOR receiver
Amir_5469	COG0642	Histidine kinase
Amir_5470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Amir_5471	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Amir_5472	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Amir_5473	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Amir_5476	COG3629	intracellular signal transduction
Amir_5476	COG3903	Transcriptional regulator
Amir_5481	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Amir_5482	COG2610	gluconate transmembrane transporter activity
Amir_5486	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Amir_5490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amir_5491	COG0640	Transcriptional regulator
Amir_5506	COG5650	phosphatidylinositol metabolic process
Amir_5512	COG4946	Tricorn protease homolog
Amir_5512	COG1506	peptidase
Amir_5512	COG0823	Involved in the tonB-independent uptake of proteins
Amir_5513	COG0861	Integral membrane protein TerC family
Amir_5514	COG1131	(ABC) transporter
Amir_5520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Amir_5520	COG0237	dephospho-CoA kinase activity
Amir_5522	COG0539	negative regulation of cytoplasmic translation
Amir_5526	COG1511	domain protein
Amir_5527	COG1309	transcriptional regulator
Amir_5530	COG0673	inositol 2-dehydrogenase activity
Amir_5533	COG2050	protein possibly involved in aromatic compounds catabolism
Amir_5535	COG0410	ABC transporter
Amir_5544	COG1832	CoA-binding protein
Amir_5545	COG0251	oxidation-reduction process
Amir_5548	COG1357	PFAM Pentapeptide repeats (8 copies)
Amir_5549	COG0514	ATP-dependent DNA helicase (RecQ)
Amir_5585	COG0758	DNA mediated transformation
Amir_5585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Amir_5586	COG1040	competence protein
Amir_5648	COG1937	Protein conserved in bacteria
Amir_5652	COG1595	DNA-templated transcription, initiation
Amir_5653	COG1408	metallophosphoesterase
Amir_5655	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Amir_5658	COG0778	Nitroreductase
Amir_5659	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Amir_5660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Amir_5662	COG1566	PFAM secretion protein HlyD family protein
Amir_5665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Amir_5666	COG1960	acyl-CoA dehydrogenase activity
Amir_5668	COG0183	Belongs to the thiolase family
Amir_5669	COG1250	3-hydroxyacyl-CoA dehydrogenase
Amir_5669	COG1024	Enoyl-CoA hydratase
Amir_5674	COG0577	efflux transmembrane transporter activity
Amir_5674	COG1136	(ABC) transporter
Amir_5675	COG1136	(ABC) transporter
Amir_5675	COG0577	efflux transmembrane transporter activity
Amir_5676	COG1672	PFAM Archaeal ATPase
Amir_5676	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Amir_5677	COG3903	Transcriptional regulator
Amir_5677	COG3629	intracellular signal transduction
Amir_5683	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Amir_5686	COG1946	Acyl-CoA thioesterase
Amir_5693	COG0070	glutamate synthase
Amir_5693	COG0069	glutamate synthase activity
Amir_5693	COG0067	glutamate synthase
Amir_5694	COG1301	dicarboxylic acid transport
Amir_5696	COG2205	protein histidine kinase activity
Amir_5698	COG0745	RESPONSE REGULATOR receiver
Amir_5699	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Amir_5700	COG0159	tryptophan synthase activity
Amir_5701	COG0133	tryptophan synthase activity
Amir_5702	COG0134	indole-3-glycerol-phosphate synthase activity
Amir_5704	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Amir_5706	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Amir_5708	COG0107	imidazoleglycerol-phosphate synthase activity
Amir_5709	COG3654	unkown
Amir_5712	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Amir_5713	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Amir_5715	COG3958	Transketolase
Amir_5716	COG3959	Transketolase, thiamine diphosphate binding domain
Amir_5718	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Amir_5720	COG0131	Imidazoleglycerol-phosphate dehydratase
Amir_5721	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Amir_5722	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Amir_5724	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Amir_5729	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Amir_5739	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Amir_5742	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Amir_5745	COG2814	Major facilitator Superfamily
Amir_5747	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Amir_5749	COG3263	regulation of cellular component size
Amir_5752	COG1872	DUF167
Amir_5753	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Amir_5757	COG1799	cell septum assembly
Amir_5761	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Amir_5762	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Amir_5763	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Amir_5768	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Amir_5769	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Amir_5772	COG0768	penicillin binding
Amir_5774	COG0275	rRNA processing
Amir_5775	COG2001	Belongs to the MraZ family
Amir_5776	COG0714	Associated with various cellular activities
Amir_5783	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Amir_5786	COG0174	glutamine synthetase
Amir_5789	COG1192	Involved in chromosome partitioning
Amir_5790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Amir_5791	COG0167	dihydroorotate dehydrogenase activity
Amir_5793	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_5794	COG2233	PERMEase
Amir_5797	COG1396	sequence-specific DNA binding
Amir_5798	COG1546	Belongs to the CinA family
Amir_5798	COG1058	Belongs to the CinA family
Amir_5800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Amir_5801	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Amir_5806	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Amir_5807	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Amir_5811	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Amir_5814	COG1309	transcriptional regulator
Amir_5816	COG0667	Aldo Keto reductase
Amir_5817	COG3214	Protein conserved in bacteria
Amir_5821	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Amir_5822	COG0612	Peptidase, M16
Amir_5823	COG1185	polyribonucleotide nucleotidyltransferase activity
Amir_5824	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Amir_5828	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Amir_5831	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Amir_5832	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Amir_5837	COG0779	Required for maturation of 30S ribosomal subunits
Amir_5842	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_5847	COG0442	prolyl-tRNA aminoacylation
Amir_5849	COG3022	response to hydroperoxide
Amir_5850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Amir_5853	COG0513	Belongs to the DEAD box helicase family
Amir_5854	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Amir_5854	COG1648	precorrin-2 dehydrogenase activity
Amir_5864	COG0156	8-amino-7-oxononanoate synthase activity
Amir_5867	COG1280	lysine exporter protein (LysE YggA)
Amir_5870	COG0501	Belongs to the peptidase M48B family
Amir_5872	COG0110	maltose O-acetyltransferase activity
Amir_5873	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Amir_5875	COG1752	Esterase of the alpha-beta hydrolase superfamily
Amir_5876	COG0726	polysaccharide deacetylase
Amir_5877	COG1881	PFAM PEBP family protein
Amir_5879	COG2807	transmembrane transport
Amir_5880	COG2186	Transcriptional regulator
Amir_5883	COG1492	cobalamin metabolic process
Amir_5888	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Amir_5889	COG0750	zinc metalloprotease
Amir_5890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Amir_5893	COG2197	response regulator
Amir_5894	COG4585	Histidine kinase
Amir_5895	COG1177	transmembrane transport
Amir_5896	COG1176	ABC-type spermidine putrescine transport system, permease component I
Amir_5898	COG3842	ATPase activity
Amir_5900	COG0515	serine threonine protein kinase
Amir_5900	COG2815	serine threonine protein kinase
Amir_5902	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Amir_5904	COG0667	Aldo Keto reductase
Amir_5908	COG0233	cytoplasmic translational termination
Amir_5909	COG0528	UMP kinase activity
Amir_5910	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Amir_5911	COG0052	Belongs to the universal ribosomal protein uS2 family
Amir_5913	COG1191	sigma factor activity
Amir_5916	COG0606	chelatase, subunit chli
Amir_5917	COG0792	nuclease activity
Amir_5919	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Amir_5920	COG0681	Belongs to the peptidase S26 family
Amir_5921	COG0681	Belongs to the peptidase S26 family
Amir_5922	COG0335	large ribosomal subunit rRNA binding
Amir_5923	COG0336	Belongs to the RNA methyltransferase TrmD family
Amir_5926	COG0228	four-way junction DNA binding
Amir_5927	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Amir_5932	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Amir_5936	COG4266	Belongs to the allantoicase family
Amir_5937	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Amir_5943	COG1414	Transcriptional regulator
Amir_5946	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Amir_5948	COG0454	-acetyltransferase
Amir_5948	COG0456	acetyltransferase
Amir_5955	COG1254	Belongs to the acylphosphatase family
Amir_5956	COG2340	Cysteine-rich secretory protein family
Amir_5959	COG1252	NADH dehydrogenase
Amir_5962	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Amir_5964	COG0571	ribonuclease III activity
Amir_5965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Amir_5968	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Amir_5969	COG0742	ribosomal rna small subunit methyltransferase
Amir_5973	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Amir_5977	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Amir_5978	COG1461	Dihydroxyacetone kinase
Amir_5979	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Amir_5982	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Amir_5983	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Amir_5988	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amir_5991	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amir_5997	COG0626	cystathionine gamma-synthase activity
Amir_5998	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Amir_6005	COG0066	3-isopropylmalate dehydratase activity
Amir_6006	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Amir_6009	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Amir_6011	COG0179	Fumarylacetoacetate (FAA) hydrolase
Amir_6013	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Amir_6014	COG0473	3-isopropylmalate dehydrogenase activity
Amir_6015	COG1404	Belongs to the peptidase S8 family
Amir_6019	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Amir_6020	COG0440	acetolactate synthase activity
Amir_6024	COG0129	dihydroxy-acid dehydratase activity
Amir_6025	COG2259	Doxx family
Amir_6034	COG0154	amidase activity
Amir_6035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Amir_6038	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Amir_6041	COG2855	membrane
Amir_6045	COG0482	sulfurtransferase activity
Amir_6050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Amir_6052	COG1307	EDD domain protein, DegV family
Amir_6056	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Amir_6061	COG0110	maltose O-acetyltransferase activity
Amir_6064	COG2226	methyltransferase
Amir_6066	COG1119	ATPase activity
Amir_6071	COG0058	SHG alpha-glucan phosphorylase activity
Amir_6072	COG0366	Alpha amylase catalytic
Amir_6073	COG0366	Alpha amylase catalytic
Amir_6075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Amir_6076	COG2321	neutral zinc metallopeptidase
Amir_6082	COG1846	Transcriptional regulator
Amir_6084	COG2409	Drug exporters of the RND superfamily
Amir_6085	COG1131	(ABC) transporter
Amir_6090	COG1609	Transcriptional regulator
Amir_6093	COG1172	Belongs to the binding-protein-dependent transport system permease family
Amir_6094	COG1879	ABC-type sugar transport system periplasmic component
Amir_6096	COG0596	Alpha beta hydrolase
Amir_6104	COG0183	Belongs to the thiolase family
Amir_6114	COG2376	Dihydroxyacetone kinase
Amir_6124	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Amir_6127	COG1024	Enoyl-CoA hydratase
Amir_6128	COG1335	isochorismatase
Amir_6135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Amir_6136	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Amir_6137	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Amir_6138	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Amir_6139	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Amir_6140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Amir_6141	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Amir_6142	COG0356	it plays a direct role in the translocation of protons across the membrane
Amir_6145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Amir_6147	COG2890	protein-(glutamine-N5) methyltransferase activity
Amir_6150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Amir_6151	COG0254	rRNA binding
Amir_6153	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Amir_6154	COG0083	homoserine kinase activity
Amir_6155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Amir_6156	COG0460	homoserine dehydrogenase
Amir_6157	COG0019	diaminopimelate decarboxylase activity
Amir_6158	COG0018	arginyl-trna synthetase
Amir_6161	COG3537	Alpha-1,2-mannosidase
Amir_6166	COG3903	Transcriptional regulator
Amir_6166	COG3629	intracellular signal transduction
Amir_6167	COG0596	Alpha beta hydrolase
Amir_6175	COG1162	GTPase activity
Amir_6178	COG0667	Aldo Keto reductase
Amir_6179	COG1609	Transcriptional regulator
Amir_6186	COG0444	Belongs to the ABC transporter superfamily
Amir_6187	COG0601	transmembrane transport
Amir_6188	COG4166	transmembrane transport
Amir_6194	COG2890	protein-(glutamine-N5) methyltransferase activity
Amir_6195	COG4941	Belongs to the sigma-70 factor family
Amir_6196	COG3795	YCII-related domain
Amir_6202	COG0640	Transcriptional regulator
Amir_6204	COG1940	carbohydrate kinase activity
Amir_6207	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Amir_6208	COG0745	RESPONSE REGULATOR receiver
Amir_6209	COG2205	protein histidine kinase activity
Amir_6213	COG1404	Belongs to the peptidase S8 family
Amir_6215	COG0583	DNA-binding transcription factor activity
Amir_6221	COG3903	Transcriptional regulator
Amir_6221	COG3629	intracellular signal transduction
Amir_6224	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Amir_6225	COG1960	acyl-CoA dehydrogenase activity
Amir_6226	COG1024	Enoyl-CoA hydratase
Amir_6228	COG1960	acyl-CoA dehydrogenase activity
Amir_6230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Amir_6238	COG3469	chitinase activity
Amir_6239	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Amir_6241	COG0673	inositol 2-dehydrogenase activity
Amir_6245	COG0386	Belongs to the glutathione peroxidase family
Amir_6246	COG1760	l-serine dehydratase
Amir_6247	COG0509	glycine decarboxylation via glycine cleavage system
Amir_6248	COG0686	Belongs to the AlaDH PNT family
Amir_6252	COG1132	(ABC) transporter
Amir_6253	COG0567	Dehydrogenase, E1 component
Amir_6253	COG0508	dehydrogenase complex catalyzes the overall conversion of
Amir_6256	COG0667	Aldo Keto reductase
Amir_6259	COG3629	intracellular signal transduction
Amir_6259	COG3903	Transcriptional regulator
Amir_6262	COG1228	amidohydrolase
Amir_6265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Amir_6266	COG2986	histidine ammonia-lyase
Amir_6270	COG1174	glycine betaine transport
Amir_6278	COG5001	Diguanylate cyclase
Amir_6280	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Amir_6284	COG0406	alpha-ribazole phosphatase activity
Amir_6288	COG1597	lipid kinase activity
Amir_6291	COG5662	AntiSigma factor
Amir_6292	COG1595	DNA-templated transcription, initiation
Amir_6293	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Amir_6295	COG2135	peptidase activity
Amir_6296	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Amir_6297	COG1162	GTPase activity
Amir_6302	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Amir_6303	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Amir_6305	COG0653	protein targeting
Amir_6306	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Amir_6307	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Amir_6308	COG5401	PFAM Sporulation and spore germination
Amir_6309	COG5002	protein histidine kinase activity
Amir_6310	COG0745	RESPONSE REGULATOR receiver
Amir_6321	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Amir_6322	COG0531	amino acid
Amir_6324	COG1482	cell wall glycoprotein biosynthetic process
Amir_6332	COG1994	Peptidase M50
Amir_6334	COG0778	Nitroreductase
Amir_6334	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Amir_6337	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Amir_6341	COG0438	transferase activity, transferring glycosyl groups
Amir_6345	COG0297	glycogen (starch) synthase activity
Amir_6348	COG1316	TRANSCRIPTIONal
Amir_6349	COG1316	TRANSCRIPTIONal
Amir_6351	COG2259	Doxx family
Amir_6358	COG2188	Transcriptional regulator
Amir_6364	COG0582	viral genome integration into host DNA
Amir_6370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Amir_6371	COG2186	Transcriptional regulator
Amir_6379	COG0483	inositol monophosphate 1-phosphatase activity
Amir_6380	COG0745	RESPONSE REGULATOR receiver
Amir_6381	COG2205	protein histidine kinase activity
Amir_6387	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Amir_6390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Amir_6393	COG0424	maF-like protein
Amir_6394	COG1301	dicarboxylic acid transport
Amir_6396	COG4770	biotin carboxylase activity
Amir_6405	COG2197	response regulator
Amir_6406	COG4585	Histidine kinase
Amir_6409	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Amir_6410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Amir_6411	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Amir_6414	COG1473	amidohydrolase
Amir_6414	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Amir_6420	COG0515	serine threonine protein kinase
Amir_6422	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Amir_6426	COG3654	unkown
Amir_6430	COG5635	Nacht domain
Amir_6430	COG2319	Wd-40 repeat
Amir_6437	COG3903	Transcriptional regulator
Amir_6437	COG3629	intracellular signal transduction
Amir_6442	COG3883	PFAM NLP P60 protein
Amir_6442	COG0791	NLP P60 protein
Amir_6446	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Amir_6462	COG2009	succinate dehydrogenase
Amir_6465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Amir_6466	COG1686	Belongs to the peptidase S11 family
Amir_6469	COG1295	ribonuclease BN
Amir_6470	COG0180	Tryptophanyl-tRNA synthetase
Amir_6472	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Amir_6475	COG0708	Exodeoxyribonuclease III
Amir_6481	COG0484	heat shock protein binding
Amir_6487	COG4555	ABC transporter
Amir_6492	COG0039	L-malate dehydrogenase activity
Amir_6498	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Amir_6503	COG0138	bifunctional purine biosynthesis protein purh
Amir_6508	COG0045	succinate-CoA ligase (ADP-forming) activity
Amir_6511	COG0739	heme binding
Amir_6520	COG2815	serine threonine protein kinase
Amir_6520	COG0515	serine threonine protein kinase
Amir_6521	COG0515	serine threonine protein kinase
Amir_6522	COG0583	DNA-binding transcription factor activity
Amir_6523	COG0697	spore germination
Amir_6529	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Amir_6529	COG0519	Catalyzes the synthesis of GMP from XMP
Amir_6531	COG1012	belongs to the aldehyde dehydrogenase family
Amir_6534	COG0516	GMP reductase activity
Amir_6543	COG0459	protein refolding
Amir_6544	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Amir_6546	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Amir_6547	COG0456	acetyltransferase
Amir_6550	COG3118	belongs to the thioredoxin family
Amir_6551	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_6556	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Amir_6558	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Amir_6563	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Amir_6564	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Amir_6565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Amir_6569	COG0443	Heat shock 70 kDa protein
Amir_6571	COG1674	ftsk spoiiie
Amir_6573	COG1404	Belongs to the peptidase S8 family
Amir_6580	COG1404	Belongs to the peptidase S8 family
Amir_6581	COG0101	tRNA pseudouridine synthase activity
Amir_6582	COG0203	ribosomal protein L17
Amir_6583	COG0202	RNA polymerase activity
Amir_6584	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Amir_6585	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Amir_6586	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Amir_6587	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Amir_6593	COG0563	adenylate kinase activity
Amir_6597	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Amir_6598	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Amir_6600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Amir_6601	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Amir_6602	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Amir_6603	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Amir_6604	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Amir_6605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Amir_6606	COG0255	Belongs to the universal ribosomal protein uL29 family
Amir_6607	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Amir_6608	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Amir_6609	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Amir_6610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Amir_6611	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Amir_6612	COG0089	rRNA binding
Amir_6613	COG0088	Forms part of the polypeptide exit tunnel
Amir_6614	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Amir_6615	COG0051	transcription antitermination factor activity, RNA binding
Amir_6616	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Amir_6617	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Amir_6618	COG0049	tRNA binding
Amir_6619	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Amir_6626	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Amir_6627	COG0085	RNA polymerase activity
Amir_6633	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Amir_6637	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Amir_6639	COG0081	regulation of translation
Amir_6640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Amir_6642	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Amir_6643	COG0436	Aminotransferase
Amir_6646	COG2030	dehydratase
Amir_6647	COG2030	dehydratase
Amir_6648	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Amir_6653	COG1666	GTP binding
Amir_6654	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Amir_6656	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amir_6657	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amir_6657	COG0649	NAD binding
Amir_6658	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amir_6661	COG1834	amidinotransferase
Amir_6662	COG1522	sequence-specific DNA binding
Amir_6664	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Amir_6664	COG0674	pyruvate-flavodoxin oxidoreductase activity
Amir_6665	COG1013	pyruvate-flavodoxin oxidoreductase activity
Amir_6669	COG1007	ATP synthesis coupled electron transport
Amir_6672	COG0713	ATP synthesis coupled electron transport
Amir_6674	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amir_6675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Amir_6676	COG1034	ATP synthesis coupled electron transport
Amir_6677	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Amir_6679	COG0649	NAD binding
Amir_6680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amir_6681	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Amir_6684	COG2226	methyltransferase
Amir_6685	COG0483	inositol monophosphate 1-phosphatase activity
Amir_6688	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Amir_6689	COG2151	metal-sulfur cluster biosynthetic enzyme
Amir_6690	COG3396	Phenylacetate-CoA oxygenase
Amir_6691	COG3460	Phenylacetate-CoA oxygenase
Amir_6692	COG3396	Phenylacetate-CoA oxygenase
Amir_6702	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Amir_6712	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Amir_6713	COG1333	cytochrome c biogenesis protein
Amir_6714	COG0785	Cytochrome C biogenesis protein
Amir_6718	COG0406	alpha-ribazole phosphatase activity
Amir_6719	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Amir_6727	COG0113	porphobilinogen synthase activity
Amir_6729	COG0181	hydroxymethylbilane synthase activity
Amir_6730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Amir_6731	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Amir_6735	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_6738	COG0560	Phosphoserine phosphatase
Amir_6743	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Amir_6750	COG5002	protein histidine kinase activity
Amir_6751	COG0667	Aldo Keto reductase
Amir_6753	COG0588	phosphoglycerate mutase activity
Amir_6754	COG0318	PFAM AMP-dependent synthetase and ligase
Amir_6757	COG0438	transferase activity, transferring glycosyl groups
Amir_6761	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Amir_6767	COG3226	Transcriptional regulator
Amir_6769	COG0789	Transcriptional regulator
Amir_6770	COG0693	protein deglycase activity
Amir_6775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Amir_6776	COG2733	membrane
Amir_6782	COG1136	(ABC) transporter
Amir_6790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amir_6791	COG2364	Membrane
Amir_6800	COG1278	Cold shock
Amir_6801	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amir_6804	COG2255	four-way junction helicase activity
Amir_6813	COG3706	GGDEF domain
Amir_6813	COG0745	RESPONSE REGULATOR receiver
Amir_6814	COG1316	TRANSCRIPTIONal
Amir_6818	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Amir_6822	COG0456	acetyltransferase
Amir_6823	COG0745	RESPONSE REGULATOR receiver
Amir_6831	COG4044	May play a role in the intracellular transport of hydrophobic ligands
Amir_6832	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Amir_6836	COG0735	belongs to the Fur family
Amir_6846	COG3962	Belongs to the TPP enzyme family
Amir_6847	COG3718	enzyme involved in inositol metabolism
Amir_6850	COG1172	Belongs to the binding-protein-dependent transport system permease family
Amir_6852	COG1082	Xylose isomerase domain protein TIM barrel
Amir_6855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Amir_6858	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Amir_6870	COG1063	alcohol dehydrogenase
Amir_6871	COG3300	MHYT domain
Amir_6871	COG5001	Diguanylate cyclase
Amir_6876	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Amir_6877	COG0047	phosphoribosylformylglycinamidine synthase activity
Amir_6878	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Amir_6883	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Amir_6885	COG0765	amino acid transport
Amir_6888	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Amir_6890	COG1595	DNA-templated transcription, initiation
Amir_6893	COG1595	DNA-templated transcription, initiation
Amir_6895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Amir_6906	COG0584	glycerophosphoryl diester phosphodiesterase
Amir_6907	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Amir_6908	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Amir_6914	COG4129	membrane
Amir_6919	COG0667	Aldo Keto reductase
Amir_6920	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_6922	COG1595	DNA-templated transcription, initiation
Amir_6927	COG0277	FAD linked oxidase domain protein
Amir_6928	COG0586	Pfam SNARE associated Golgi protein
Amir_6929	COG1072	(Pantothenic acid kinase))
Amir_6930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Amir_6936	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Amir_6941	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_6943	COG0542	response to heat
Amir_6945	COG2871	sodium ion transport
Amir_6946	COG0789	Transcriptional regulator
Amir_6947	COG0484	heat shock protein binding
Amir_6948	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Amir_6949	COG0443	Heat shock 70 kDa protein
Amir_6953	COG2181	nitrate reductase activity
Amir_6953	COG0247	lactate metabolic process
Amir_6954	COG1950	PFAM Membrane protein of
Amir_6959	COG0717	Belongs to the dCTP deaminase family
Amir_6962	COG2197	response regulator
Amir_6963	COG1960	acyl-CoA dehydrogenase activity
Amir_6966	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Amir_6973	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_6977	COG1960	acyl-CoA dehydrogenase activity
Amir_6979	COG1309	transcriptional regulator
Amir_6980	COG0789	Transcriptional regulator
Amir_6981	COG0508	dehydrogenase complex catalyzes the overall conversion of
Amir_6982	COG0022	dehydrogenase e1 component
Amir_6984	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Amir_6986	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Amir_6987	COG0765	amino acid transport
Amir_6994	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Amir_7000	COG1940	carbohydrate kinase activity
Amir_7008	COG4585	Histidine kinase
Amir_7009	COG2197	response regulator
Amir_7010	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_7012	COG0561	phosphatase activity
Amir_7014	COG4585	Histidine kinase
Amir_7016	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Amir_7020	COG1131	(ABC) transporter
Amir_7024	COG0402	S-adenosylhomocysteine deaminase activity
Amir_7025	COG4221	oxidoreductase activity
Amir_7028	COG2814	Major facilitator Superfamily
Amir_7029	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Amir_7030	COG1028	Short-chain dehydrogenase reductase Sdr
Amir_7034	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Amir_7039	COG0360	Binds together with S18 to 16S ribosomal RNA
Amir_7040	COG0629	single-stranded DNA binding
Amir_7041	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Amir_7042	COG0359	binds to the 23S rRNA
Amir_7043	COG0305	Participates in initiation and elongation during chromosome replication
Amir_7048	COG2203	Gaf domain
Amir_7048	COG5001	Diguanylate cyclase
Amir_7048	COG4251	negative regulation of phosphorylation
Amir_7048	COG3706	GGDEF domain
Amir_7053	COG3706	GGDEF domain
Amir_7053	COG0745	RESPONSE REGULATOR receiver
Amir_7062	COG0702	epimerase
Amir_7063	COG1063	alcohol dehydrogenase
Amir_7065	COG0583	DNA-binding transcription factor activity
Amir_7069	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Amir_7070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Amir_7074	COG0495	leucyl-tRNA aminoacylation
Amir_7079	COG0617	tRNA 3'-terminal CCA addition
Amir_7083	COG0515	serine threonine protein kinase
Amir_7084	COG1595	DNA-templated transcription, initiation
Amir_7087	COG0492	ferredoxin-NADP+ reductase activity
Amir_7087	COG3118	belongs to the thioredoxin family
Amir_7088	COG3409	Peptidoglycan-binding domain 1 protein
Amir_7088	COG0860	N-Acetylmuramoyl-L-alanine amidase
Amir_7090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Amir_7091	COG1181	Belongs to the D-alanine--D-alanine ligase family
Amir_7093	COG1192	Involved in chromosome partitioning
Amir_7094	COG0357	Ribosomal RNA small subunit methyltransferase G
Amir_7097	COG0706	membrane insertase activity
Amir_7098	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Amir_7099	COG0594	ribonuclease P activity
Amir_7100	COG0230	Belongs to the bacterial ribosomal protein bL34 family