locus-tag	class	description
APASM_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APASM_0002	COG0592	DNA-directed DNA polymerase activity
APASM_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APASM_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APASM_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
APASM_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APASM_0010	COG2259	Doxx family
APASM_0013	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APASM_0014	COG0705	Rhomboid family
APASM_0017	COG3764	Sortase (surface protein transpeptidase)
APASM_0021	COG2815	serine threonine protein kinase
APASM_0021	COG0515	serine threonine protein kinase
APASM_0022	COG0515	serine threonine protein kinase
APASM_0023	COG0768	penicillin binding
APASM_0027	COG1716	ATPase activity
APASM_0028	COG1716	ATPase activity
APASM_0034	COG1309	transcriptional regulator
APASM_0036	COG2211	Major facilitator Superfamily
APASM_0037	COG0300	oxidoreductase activity
APASM_0039	COG3281	Trehalose synthase
APASM_0045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APASM_0051	COG0405	Gamma-glutamyltransferase
APASM_0057	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_0060	COG2226	methyltransferase
APASM_0066	COG3275	phosphorelay sensor kinase activity
APASM_0069	COG3279	Response regulator of the LytR AlgR family
APASM_0071	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_0073	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_0077	COG0584	glycerophosphoryl diester phosphodiesterase
APASM_0080	COG0653	protein targeting
APASM_0083	COG1528	Iron-storage protein
APASM_0093	COG1271	oxidase subunit
APASM_0094	COG1294	oxidase, subunit
APASM_0096	COG4988	ABC transporter
APASM_0098	COG0454	-acetyltransferase
APASM_0108	COG1501	Belongs to the glycosyl hydrolase 31 family
APASM_0116	COG0754	glutathionylspermidine amidase activity
APASM_0117	COG3766	membrane
APASM_0119	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APASM_0122	COG0579	oxidoreductase
APASM_0124	COG0561	phosphatase activity
APASM_0126	COG0463	Glycosyl transferase, family 2
APASM_0130	COG1216	Glycosyl transferase, family 2
APASM_0136	COG1216	Glycosyl transferase, family 2
APASM_0145	COG2234	aminopeptidase activity
APASM_0147	COG0737	Belongs to the 5'-nucleotidase family
APASM_0147	COG1525	nuclease
APASM_0147	COG4085	toxin activity
APASM_0150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APASM_0155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_0157	COG1686	Belongs to the peptidase S11 family
APASM_0158	COG5295	Hep Hag repeat protein
APASM_0158	COG4932	domain protein
APASM_0167	COG0183	Belongs to the thiolase family
APASM_0170	COG0287	Prephenate dehydrogenase
APASM_0171	COG1473	amidohydrolase
APASM_0181	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APASM_0182	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APASM_0184	COG3629	intracellular signal transduction
APASM_0184	COG3903	Transcriptional regulator
APASM_0185	COG0747	negative chemotaxis
APASM_0188	COG0444	Belongs to the ABC transporter superfamily
APASM_0189	COG4608	Belongs to the ABC transporter superfamily
APASM_0198	COG1070	Carbohydrate kinase
APASM_0201	COG1764	response to oxidative stress
APASM_0203	COG0431	NADPH-dependent FMN reductase
APASM_0209	COG1408	metallophosphoesterase
APASM_0226	COG0592	DNA-directed DNA polymerase activity
APASM_0227	COG2814	Major facilitator Superfamily
APASM_0231	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APASM_0234	COG0596	Alpha beta hydrolase
APASM_0236	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APASM_0237	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_0240	COG3844	kynureninase activity
APASM_0242	COG1522	sequence-specific DNA binding
APASM_0243	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APASM_0244	COG1737	Transcriptional regulator
APASM_0248	COG3876	Protein conserved in bacteria
APASM_0251	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_0262	COG1205	dead DEAH box helicase
APASM_0262	COG1111	helicase
APASM_0263	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
APASM_0270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APASM_0270	COG1754	DNA topoisomerase type I activity
APASM_0273	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APASM_0274	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APASM_0277	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
APASM_0278	COG1120	ATPase activity
APASM_0287	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APASM_0290	COG0037	tRNA processing
APASM_0293	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APASM_0294	COG0302	gtp cyclohydrolase
APASM_0295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APASM_0296	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APASM_0299	COG0649	NAD binding
APASM_0304	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APASM_0305	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APASM_0306	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APASM_0308	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APASM_0310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_0311	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_0312	COG1120	ATPase activity
APASM_0315	COG0542	response to heat
APASM_0316	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
APASM_0318	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APASM_0322	COG1194	a g-specific adenine glycosylase
APASM_0325	COG1653	transport
APASM_0326	COG1175	transmembrane transport
APASM_0327	COG3833	ABC-type maltose transport systems, permease component
APASM_0330	COG1121	(ABC) transporter
APASM_0331	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APASM_0332	COG3706	GGDEF domain
APASM_0332	COG0745	RESPONSE REGULATOR receiver
APASM_0337	COG0215	cysteine-tRNA ligase activity
APASM_0339	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APASM_0340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APASM_0341	COG1329	Transcriptional regulator
APASM_0345	COG4221	oxidoreductase activity
APASM_0348	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APASM_0354	COG2205	protein histidine kinase activity
APASM_0355	COG0745	RESPONSE REGULATOR receiver
APASM_0361	COG3903	Transcriptional regulator
APASM_0361	COG3629	intracellular signal transduction
APASM_0365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_0366	COG0583	DNA-binding transcription factor activity
APASM_0368	COG0179	Fumarylacetoacetate (FAA) hydrolase
APASM_0369	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_0370	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_0374	COG2186	Transcriptional regulator
APASM_0376	COG1175	transmembrane transport
APASM_0378	COG2188	Transcriptional regulator
APASM_0379	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_0380	COG3384	dioxygenase
APASM_0381	COG0352	thiamine-phosphate diphosphorylase activity
APASM_0384	COG2022	thiamine diphosphate biosynthetic process
APASM_0386	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_0391	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_0397	COG0351	phosphomethylpyrimidine kinase
APASM_0398	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APASM_0403	COG1802	Transcriptional regulator
APASM_0405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APASM_0409	COG0688	phosphatidylethanolamine metabolic process
APASM_0413	COG1278	Cold shock
APASM_0415	COG0459	protein refolding
APASM_0418	COG3142	Participates in the control of copper homeostasis
APASM_0420	COG1175	transmembrane transport
APASM_0422	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APASM_0425	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_0432	COG2018	Roadblock/LC7 domain
APASM_0440	COG0521	Mo-molybdopterin cofactor biosynthetic process
APASM_0440	COG0315	cyclic pyranopterin monophosphate synthase activity
APASM_0442	COG1388	LysM domain
APASM_0444	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APASM_0445	COG1846	Transcriptional regulator
APASM_0449	COG3304	Inner membrane component domain
APASM_0454	COG1278	Cold shock
APASM_0460	COG2252	PERMEase
APASM_0462	COG2814	Major facilitator Superfamily
APASM_0465	COG0488	(ABC) transporter
APASM_0468	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APASM_0472	COG5492	domain, Protein
APASM_0473	COG0259	pyridoxamine-phosphate oxidase activity
APASM_0474	COG0829	nickel cation binding
APASM_0476	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APASM_0478	COG0804	urea catabolic process
APASM_0483	COG2197	response regulator
APASM_0489	COG1132	(ABC) transporter
APASM_0491	COG1132	(ABC) transporter
APASM_0493	COG1309	transcriptional regulator
APASM_0494	COG0531	amino acid
APASM_0495	COG2017	converts alpha-aldose to the beta-anomer
APASM_0496	COG1228	amidohydrolase
APASM_0497	COG1960	acyl-CoA dehydrogenase activity
APASM_0502	COG0415	Belongs to the DNA photolyase family
APASM_0503	COG2197	response regulator
APASM_0505	COG1668	transmembrane transport
APASM_0506	COG4152	abc transporter atp-binding protein
APASM_0511	COG0402	S-adenosylhomocysteine deaminase activity
APASM_0512	COG2130	NADP-dependent
APASM_0515	COG1674	ftsk spoiiie
APASM_0520	COG2267	carboxylic ester hydrolase activity
APASM_0521	COG0583	DNA-binding transcription factor activity
APASM_0522	COG0384	phenazine biosynthesis protein PhzF
APASM_0523	COG0583	DNA-binding transcription factor activity
APASM_0524	COG0702	epimerase
APASM_0525	COG1733	regulation of RNA biosynthetic process
APASM_0531	COG2197	response regulator
APASM_0543	COG3209	COG3209 Rhs family protein
APASM_0559	COG2197	response regulator
APASM_0560	COG5001	Diguanylate cyclase
APASM_0560	COG5002	protein histidine kinase activity
APASM_0560	COG3447	MASE1 domain protein
APASM_0561	COG0778	Nitroreductase
APASM_0562	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APASM_0563	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APASM_0565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APASM_0576	COG1349	DNA-binding transcription factor activity
APASM_0580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APASM_0583	COG0315	cyclic pyranopterin monophosphate synthase activity
APASM_0583	COG0521	Mo-molybdopterin cofactor biosynthetic process
APASM_0585	COG1970	mechanosensitive ion channel activity
APASM_0588	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APASM_0589	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APASM_0591	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APASM_0596	COG0515	serine threonine protein kinase
APASM_0596	COG2815	serine threonine protein kinase
APASM_0601	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_0602	COG0084	hydrolase, TatD family'
APASM_0603	COG3583	domain protein
APASM_0604	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APASM_0605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APASM_0606	COG2011	ABC-type metal ion transport system permease component
APASM_0608	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APASM_0609	COG0488	(ABC) transporter
APASM_0612	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_0613	COG0193	aminoacyl-tRNA hydrolase activity
APASM_0617	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APASM_0618	COG0745	RESPONSE REGULATOR receiver
APASM_0618	COG3706	GGDEF domain
APASM_0623	COG2133	pyrroloquinoline quinone binding
APASM_0628	COG3956	TIGRFAM MazG family protein
APASM_0629	COG0793	Belongs to the peptidase S41A family
APASM_0629	COG4946	Tricorn protease homolog
APASM_0632	COG0148	phosphopyruvate hydratase activity
APASM_0636	COG4166	transmembrane transport
APASM_0640	COG4608	Belongs to the ABC transporter superfamily
APASM_0643	COG0714	Associated with various cellular activities
APASM_0656	COG0183	Belongs to the thiolase family
APASM_0662	COG3185	4-Hydroxyphenylpyruvate dioxygenase
APASM_0664	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APASM_0666	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APASM_0670	COG1331	Highly conserved protein containing a thioredoxin domain
APASM_0672	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APASM_0675	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APASM_0677	COG1793	dna ligase
APASM_0678	COG0114	fumarate hydratase activity
APASM_0679	COG0492	ferredoxin-NADP+ reductase activity
APASM_0683	COG1722	exodeoxyribonuclease VII activity
APASM_0685	COG1570	exodeoxyribonuclease VII activity
APASM_0687	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APASM_0691	COG0419	ATPase involved in DNA repair
APASM_0694	COG0012	GTP binding
APASM_0699	COG1051	belongs to the nudix hydrolase family
APASM_0701	COG2154	pterin-4-alpha-carbinolamine dehydratase
APASM_0703	COG4149	molybdate abc transporter
APASM_0704	COG3842	ATPase activity
APASM_0709	COG1131	(ABC) transporter
APASM_0714	COG0494	nUDIX hydrolase
APASM_0715	COG0180	Tryptophanyl-tRNA synthetase
APASM_0719	COG0747	negative chemotaxis
APASM_0720	COG4166	transmembrane transport
APASM_0724	COG4608	Belongs to the ABC transporter superfamily
APASM_0725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APASM_0732	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_0733	COG1611	Belongs to the LOG family
APASM_0734	COG1611	Belongs to the LOG family
APASM_0736	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APASM_0740	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_0745	COG1024	Enoyl-CoA hydratase
APASM_0746	COG3327	negative regulation of DNA-templated transcription, initiation
APASM_0748	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APASM_0749	COG0583	DNA-binding transcription factor activity
APASM_0752	COG0297	glycogen (starch) synthase activity
APASM_0753	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APASM_0757	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APASM_0761	COG2239	Acts as a magnesium transporter
APASM_0762	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
APASM_0775	COG0598	Magnesium transport protein CorA
APASM_0783	COG0513	Belongs to the DEAD box helicase family
APASM_0794	COG0243	molybdopterin cofactor binding
APASM_0796	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_0798	COG2223	nitrite transmembrane transporter activity
APASM_0800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_0800	COG2146	nitrite reductase [NAD(P)H] activity
APASM_0801	COG2146	nitrite reductase [NAD(P)H] activity
APASM_0801	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_0805	COG0745	RESPONSE REGULATOR receiver
APASM_0806	COG2205	protein histidine kinase activity
APASM_0813	COG0210	DNA helicase
APASM_0816	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_0817	COG0583	DNA-binding transcription factor activity
APASM_0825	COG0612	Peptidase, M16
APASM_0827	COG1940	carbohydrate kinase activity
APASM_0827	COG1846	Transcriptional regulator
APASM_0833	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APASM_0842	COG0406	alpha-ribazole phosphatase activity
APASM_0842	COG0328	RNA-DNA hybrid ribonuclease activity
APASM_0843	COG0431	NADPH-dependent FMN reductase
APASM_0850	COG0791	NLP P60 protein
APASM_0855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APASM_0859	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APASM_0861	COG3842	ATPase activity
APASM_0865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APASM_0868	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APASM_0868	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APASM_0869	COG0174	glutamine synthetase
APASM_0872	COG1522	sequence-specific DNA binding
APASM_0874	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_0874	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APASM_0877	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APASM_0889	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APASM_0896	COG1615	UPF0182 protein
APASM_0898	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APASM_0899	COG2884	Cell division ATP-binding protein ftsE
APASM_0900	COG2177	Part of the ABC transporter FtsEX involved in
APASM_0901	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APASM_0902	COG2197	response regulator
APASM_0903	COG4585	Histidine kinase
APASM_0904	COG1643	Atp-dependent helicase
APASM_0906	COG0456	acetyltransferase
APASM_0906	COG0454	-acetyltransferase
APASM_0907	COG2814	Major facilitator Superfamily
APASM_0909	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
APASM_0927	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APASM_0929	COG1111	helicase
APASM_0929	COG1205	dead DEAH box helicase
APASM_0930	COG0210	DNA helicase
APASM_0931	COG3629	intracellular signal transduction
APASM_0931	COG3903	Transcriptional regulator
APASM_0938	COG1175	transmembrane transport
APASM_0939	COG0395	ABC-type sugar transport system, permease component
APASM_0942	COG1609	Transcriptional regulator
APASM_0948	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APASM_0949	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APASM_0950	COG0235	Class ii aldolase
APASM_0951	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APASM_0953	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APASM_0954	COG3830	Belongs to the UPF0237 family
APASM_0954	COG0560	Phosphoserine phosphatase
APASM_0966	COG1335	isochorismatase
APASM_0967	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APASM_0968	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APASM_0974	COG1234	tRNA 3'-trailer cleavage
APASM_0975	COG3386	PFAM SMP-30 Gluconolaconase
APASM_0977	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APASM_0978	COG1234	tRNA 3'-trailer cleavage
APASM_0982	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APASM_0983	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APASM_0987	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_0988	COG2072	flavoprotein involved in K transport
APASM_0989	COG0586	Pfam SNARE associated Golgi protein
APASM_0998	COG2949	membrane
APASM_0999	COG1316	TRANSCRIPTIONal
APASM_1000	COG0751	glycine-tRNA ligase activity
APASM_1000	COG0752	glycyl-tRNA synthetase alpha subunit
APASM_1002	COG4213	ABC transporter substrate-binding protein
APASM_1005	COG1278	Cold shock
APASM_1007	COG3345	alpha-galactosidase
APASM_1009	COG4279	zinc finger
APASM_1010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APASM_1018	COG0488	(ABC) transporter
APASM_1019	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APASM_1021	COG4977	sequence-specific DNA binding
APASM_1025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APASM_1025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APASM_1031	COG1846	Transcriptional regulator
APASM_1032	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APASM_1037	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APASM_1037	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APASM_1045	COG4106	trans-aconitate 2-methyltransferase activity
APASM_1046	COG0506	proline dehydrogenase activity
APASM_1047	COG1012	belongs to the aldehyde dehydrogenase family
APASM_1052	COG1012	belongs to the aldehyde dehydrogenase family
APASM_1061	COG0740	serine-type endopeptidase activity
APASM_1062	COG0740	serine-type endopeptidase activity
APASM_1064	COG1609	Transcriptional regulator
APASM_1065	COG2223	nitrite transmembrane transporter activity
APASM_1067	COG3336	cytochrome c oxidase
APASM_1075	COG2902	Dehydrogenase
APASM_1080	COG0366	Alpha amylase catalytic
APASM_1082	COG0668	transmembrane transport
APASM_1083	COG1505	serine-type exopeptidase activity
APASM_1087	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APASM_1089	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APASM_1095	COG4552	Acetyltransferase involved in intracellular survival and related
APASM_1097	COG0583	DNA-binding transcription factor activity
APASM_1098	COG0544	peptidyl-prolyl cis-trans isomerase activity
APASM_1099	COG0740	serine-type endopeptidase activity
APASM_1100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APASM_1103	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APASM_1112	COG0525	valine-tRNA ligase activity
APASM_1113	COG0285	dihydrofolate synthase activity
APASM_1137	COG0105	UTP biosynthetic process
APASM_1138	COG1131	(ABC) transporter
APASM_1140	COG0842	Transport permease protein
APASM_1147	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APASM_1153	COG1530	ribonuclease E activity
APASM_1153	COG1530	ribonuclease E activity
APASM_1154	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APASM_1155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APASM_1156	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APASM_1158	COG0477	Major facilitator Superfamily
APASM_1163	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APASM_1164	COG0799	negative regulation of ribosome biogenesis
APASM_1166	COG2755	lipolytic protein G-D-S-L family
APASM_1167	COG1307	EDD domain protein, DegV family
APASM_1168	COG1555	photosystem II stabilization
APASM_1168	COG1596	polysaccharide export
APASM_1169	COG2333	competence protein COMEC
APASM_1169	COG0658	competence protein
APASM_1173	COG0268	Binds directly to 16S ribosomal RNA
APASM_1179	COG2308	Evidence 4 Homologs of previously reported genes of
APASM_1181	COG1305	Transglutaminase-like
APASM_1183	COG0481	GTPase activity
APASM_1186	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APASM_1190	COG0531	amino acid
APASM_1192	COG0604	alcohol dehydrogenase
APASM_1195	COG2732	(Barnase) inhibitor
APASM_1199	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_1200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APASM_1206	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_1208	COG1420	regulation of RNA biosynthetic process
APASM_1209	COG0484	heat shock protein binding
APASM_1213	COG0596	Alpha beta hydrolase
APASM_1214	COG0537	adenosine 5'-monophosphoramidase activity
APASM_1217	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APASM_1223	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APASM_1224	COG1381	Involved in DNA repair and RecF pathway recombination
APASM_1225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APASM_1234	COG0423	glycine-tRNA ligase activity
APASM_1239	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APASM_1241	COG3340	Belongs to the peptidase S51 family
APASM_1242	COG1595	DNA-templated transcription, initiation
APASM_1243	COG0358	DNA primase activity
APASM_1249	COG1674	ftsk spoiiie
APASM_1257	COG4106	trans-aconitate 2-methyltransferase activity
APASM_1258	COG1316	TRANSCRIPTIONal
APASM_1261	COG0726	polysaccharide deacetylase
APASM_1263	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
APASM_1264	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APASM_1269	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APASM_1270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APASM_1272	COG2084	Dehydrogenase
APASM_1279	COG1132	(ABC) transporter
APASM_1280	COG1132	(ABC) transporter
APASM_1283	COG0515	serine threonine protein kinase
APASM_1286	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_1287	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APASM_1291	COG3201	nicotinamide mononucleotide transporter
APASM_1292	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APASM_1298	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APASM_1302	COG0321	lipoyl(octanoyl) transferase activity
APASM_1304	COG0702	epimerase
APASM_1307	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_1308	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APASM_1313	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APASM_1314	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APASM_1317	COG0667	Aldo Keto reductase
APASM_1325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APASM_1327	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_1327	COG0204	Acyl-transferase
APASM_1329	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APASM_1332	COG1845	cytochrome c oxidase, subunit III
APASM_1333	COG2010	Cytochrome c
APASM_1335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APASM_1341	COG0438	transferase activity, transferring glycosyl groups
APASM_1346	COG0003	Pfam Anion-transporting ATPase
APASM_1348	COG1940	carbohydrate kinase activity
APASM_1354	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APASM_1361	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APASM_1366	COG0442	prolyl-tRNA aminoacylation
APASM_1373	COG1201	RNA secondary structure unwinding
APASM_1375	COG0443	Heat shock 70 kDa protein
APASM_1376	COG2814	Major facilitator Superfamily
APASM_1379	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APASM_1380	COG2137	regulation of response to DNA damage stimulus
APASM_1382	COG0800	Aldolase
APASM_1394	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APASM_1396	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APASM_1398	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APASM_1401	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APASM_1402	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APASM_1404	COG1196	nuclear chromosome segregation
APASM_1406	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APASM_1408	COG0642	Histidine kinase
APASM_1409	COG0745	RESPONSE REGULATOR receiver
APASM_1410	COG1126	abc transporter atp-binding protein
APASM_1412	COG0765	amino acid transport
APASM_1413	COG0765	amino acid transport
APASM_1419	COG1515	deoxyribonuclease V activity
APASM_1420	COG1486	melibiose metabolic process
APASM_1421	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APASM_1422	COG2936	dipeptidyl-peptidase activity
APASM_1424	COG1506	peptidase
APASM_1424	COG0823	Involved in the tonB-independent uptake of proteins
APASM_1424	COG4946	Tricorn protease homolog
APASM_1425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APASM_1427	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
APASM_1432	COG0123	including yeast histone deacetylase and acetoin utilization protein
APASM_1434	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_1435	COG2188	Transcriptional regulator
APASM_1439	COG1690	Belongs to the RtcB family
APASM_1449	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_1451	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APASM_1452	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_1459	COG1490	D-aminoacyl-tRNA deacylase activity
APASM_1460	COG2890	protein-(glutamine-N5) methyltransferase activity
APASM_1464	COG2313	pseudouridylate synthase activity
APASM_1467	COG1061	Type III restriction enzyme res subunit
APASM_1470	COG4214	carbohydrate transport
APASM_1482	COG0569	domain protein
APASM_1483	COG0531	amino acid
APASM_1484	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APASM_1485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APASM_1487	COG0745	RESPONSE REGULATOR receiver
APASM_1488	COG2205	protein histidine kinase activity
APASM_1504	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_1504	COG1024	Enoyl-CoA hydratase
APASM_1509	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APASM_1510	COG2197	response regulator
APASM_1513	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APASM_1516	COG1404	Belongs to the peptidase S8 family
APASM_1521	COG3220	belongs to the UPF0276 family
APASM_1527	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APASM_1532	COG1960	acyl-CoA dehydrogenase activity
APASM_1533	COG1960	acyl-CoA dehydrogenase activity
APASM_1534	COG3285	dna ligase
APASM_1534	COG1793	dna ligase
APASM_1542	COG5006	permease, DMT superfamily
APASM_1543	COG1793	dna ligase
APASM_1547	COG0488	(ABC) transporter
APASM_1549	COG2706	6-phosphogluconolactonase activity
APASM_1550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_1555	COG1316	TRANSCRIPTIONal
APASM_1558	COG0671	phosphoesterase, PA-phosphatase related
APASM_1560	COG0653	protein targeting
APASM_1563	COG1960	acyl-CoA dehydrogenase activity
APASM_1568	COG1309	transcriptional regulator
APASM_1578	COG0475	glutathione-regulated potassium exporter activity
APASM_1582	COG1160	GTP binding
APASM_1583	COG2197	response regulator
APASM_1587	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APASM_1601	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APASM_1604	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APASM_1614	COG1132	(ABC) transporter
APASM_1623	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APASM_1625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_1626	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_1628	COG0438	transferase activity, transferring glycosyl groups
APASM_1630	COG1215	transferase activity, transferring glycosyl groups
APASM_1636	COG1131	(ABC) transporter
APASM_1638	COG2197	response regulator
APASM_1675	COG0328	RNA-DNA hybrid ribonuclease activity
APASM_1678	COG3345	alpha-galactosidase
APASM_1679	COG3903	Transcriptional regulator
APASM_1679	COG3629	intracellular signal transduction
APASM_1684	COG0410	ABC transporter
APASM_1693	COG0601	transmembrane transport
APASM_1694	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_1695	COG0444	Belongs to the ABC transporter superfamily
APASM_1702	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
APASM_1703	COG2318	DinB family
APASM_1704	COG2255	four-way junction helicase activity
APASM_1705	COG0632	four-way junction helicase activity
APASM_1710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APASM_1711	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APASM_1712	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APASM_1713	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APASM_1715	COG0124	histidyl-tRNA synthetase
APASM_1722	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APASM_1723	COG0439	Biotin carboxylase
APASM_1728	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APASM_1732	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APASM_1734	COG2205	protein histidine kinase activity
APASM_1735	COG0745	RESPONSE REGULATOR receiver
APASM_1737	COG2372	response to copper ion
APASM_1741	COG0673	inositol 2-dehydrogenase activity
APASM_1744	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APASM_1747	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APASM_1753	COG2244	polysaccharide biosynthetic process
APASM_1765	COG2153	protein acetylation
APASM_1771	COG0667	Aldo Keto reductase
APASM_1772	COG0596	Alpha beta hydrolase
APASM_1772	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APASM_1772	COG2226	methyltransferase
APASM_1773	COG1024	Enoyl-CoA hydratase
APASM_1778	COG1295	ribonuclease BN
APASM_1781	COG1126	abc transporter atp-binding protein
APASM_1782	COG0765	amino acid transport
APASM_1784	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APASM_1791	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APASM_1795	COG0395	ABC-type sugar transport system, permease component
APASM_1796	COG2723	6-phospho-beta-galactosidase activity
APASM_1798	COG4249	Peptidase C14 caspase catalytic subunit p20
APASM_1798	COG2319	Wd-40 repeat
APASM_1799	COG1940	carbohydrate kinase activity
APASM_1800	COG2115	Belongs to the xylose isomerase family
APASM_1801	COG1070	Carbohydrate kinase
APASM_1807	COG2207	Transcriptional regulator
APASM_1807	COG3708	Transcriptional regulator
APASM_1819	COG0640	Transcriptional regulator
APASM_1826	COG0791	NLP P60 protein
APASM_1830	COG1609	Transcriptional regulator
APASM_1831	COG1609	Transcriptional regulator
APASM_1834	COG3458	cephalosporin-C deacetylase activity
APASM_1839	COG4941	Belongs to the sigma-70 factor family
APASM_1845	COG0492	ferredoxin-NADP+ reductase activity
APASM_1847	COG1785	Belongs to the alkaline phosphatase family
APASM_1851	COG3866	Pectate lyase
APASM_1853	COG0395	ABC-type sugar transport system, permease component
APASM_1855	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_1860	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_1861	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_1863	COG1879	ABC-type sugar transport system periplasmic component
APASM_1866	COG3940	Belongs to the glycosyl hydrolase 43 family
APASM_1867	COG1609	Transcriptional regulator
APASM_1870	COG2160	L-arabinose isomerase activity
APASM_1871	COG4213	ABC transporter substrate-binding protein
APASM_1873	COG4214	carbohydrate transport
APASM_1876	COG3401	FG-GAP repeat protein
APASM_1879	COG1609	Transcriptional regulator
APASM_1884	COG2356	endonuclease I
APASM_1886	COG4585	Histidine kinase
APASM_1890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APASM_1891	COG4715	Zinc finger, swim domain protein
APASM_1892	COG3552	Protein containing von Willebrand factor type A (VWA) domain
APASM_1893	COG2425	protein containing a von Willebrand factor type A (vWA) domain
APASM_1894	COG0714	Associated with various cellular activities
APASM_1895	COG3831	ATPase activity
APASM_1896	COG3831	ATPase activity
APASM_1897	COG3831	ATPase activity
APASM_1898	COG0438	transferase activity, transferring glycosyl groups
APASM_1904	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APASM_1907	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APASM_1908	COG2326	polyphosphate kinase activity
APASM_1909	COG2261	transglycosylase associated protein
APASM_1925	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APASM_1926	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APASM_1927	COG0515	serine threonine protein kinase
APASM_1927	COG2815	serine threonine protein kinase
APASM_1929	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APASM_1929	COG2755	lipolytic protein G-D-S-L family
APASM_1931	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APASM_1936	COG0395	ABC-type sugar transport system, permease component
APASM_1938	COG0702	epimerase
APASM_1940	COG0745	RESPONSE REGULATOR receiver
APASM_1944	COG2197	response regulator
APASM_1945	COG4585	Histidine kinase
APASM_1947	COG1131	(ABC) transporter
APASM_1960	COG0477	Major facilitator Superfamily
APASM_1968	COG2124	cytochrome p450
APASM_1969	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APASM_1978	COG2264	protein methyltransferase activity
APASM_1986	COG0395	ABC-type sugar transport system, permease component
APASM_1987	COG4209	transmembrane transport
APASM_1989	COG1609	Transcriptional regulator
APASM_1996	COG1011	Hydrolase
APASM_1999	COG1295	ribonuclease BN
APASM_2001	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_2002	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APASM_2005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APASM_2007	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APASM_2015	COG2197	response regulator
APASM_2018	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_2022	COG1595	DNA-templated transcription, initiation
APASM_2050	COG2188	Transcriptional regulator
APASM_2051	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APASM_2057	COG1834	amidinotransferase
APASM_2058	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APASM_2060	COG3483	tryptophan 2,3-dioxygenase activity
APASM_2064	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_2067	COG1132	(ABC) transporter
APASM_2071	COG2181	nitrate reductase activity
APASM_2072	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APASM_2073	COG1140	nitrate reductase beta subunit
APASM_2081	COG5297	Belongs to the glycosyl hydrolase family 6
APASM_2083	COG1732	Glycine betaine
APASM_2084	COG1174	glycine betaine transport
APASM_2085	COG0517	IMP dehydrogenase activity
APASM_2085	COG1125	glycine betaine transport
APASM_2086	COG1174	glycine betaine transport
APASM_2091	COG3842	ATPase activity
APASM_2096	COG0590	tRNA wobble adenosine to inosine editing
APASM_2098	COG3835	regulator
APASM_2104	COG0492	ferredoxin-NADP+ reductase activity
APASM_2106	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APASM_2108	COG2340	Cysteine-rich secretory protein family
APASM_2109	COG0531	amino acid
APASM_2111	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APASM_2114	COG2186	Transcriptional regulator
APASM_2122	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APASM_2126	COG1560	Kdo2-lipid A biosynthetic process
APASM_2127	COG0438	transferase activity, transferring glycosyl groups
APASM_2128	COG1051	belongs to the nudix hydrolase family
APASM_2132	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APASM_2134	COG1953	Uracil, thiamine, allantoin
APASM_2142	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
APASM_2143	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
APASM_2144	COG0217	transcriptional regulatory protein
APASM_2147	COG1309	transcriptional regulator
APASM_2148	COG0477	Major facilitator Superfamily
APASM_2150	COG2124	cytochrome p450
APASM_2156	COG3572	ergothioneine biosynthetic process
APASM_2157	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APASM_2159	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APASM_2167	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APASM_2171	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APASM_2173	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_2174	COG0791	NLP P60 protein
APASM_2174	COG3883	PFAM NLP P60 protein
APASM_2177	COG0500	methyltransferase
APASM_2178	COG0714	Associated with various cellular activities
APASM_2183	COG5002	protein histidine kinase activity
APASM_2194	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APASM_2198	COG3012	SEC-C Motif Domain Protein
APASM_2200	COG4733	cellulase activity
APASM_2200	COG5297	Belongs to the glycosyl hydrolase family 6
APASM_2201	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_2204	COG4209	transmembrane transport
APASM_2205	COG0395	ABC-type sugar transport system, permease component
APASM_2208	COG1324	tolerance protein
APASM_2212	COG0277	FAD linked oxidase domain protein
APASM_2212	COG0247	lactate metabolic process
APASM_2214	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APASM_2218	COG4221	oxidoreductase activity
APASM_2222	COG5297	Belongs to the glycosyl hydrolase family 6
APASM_2223	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APASM_2229	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APASM_2231	COG0215	cysteine-tRNA ligase activity
APASM_2237	COG0745	RESPONSE REGULATOR receiver
APASM_2238	COG0745	RESPONSE REGULATOR receiver
APASM_2239	COG5002	protein histidine kinase activity
APASM_2241	COG1410	methionine synthase
APASM_2241	COG0646	methionine synthase
APASM_2242	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APASM_2245	COG0446	pyridine nucleotide-disulphide oxidoreductase
APASM_2245	COG1902	pentaerythritol trinitrate reductase activity
APASM_2246	COG0300	oxidoreductase activity
APASM_2248	COG0140	phosphoribosyl-ATP diphosphatase activity
APASM_2249	COG0679	Auxin Efflux Carrier
APASM_2253	COG0517	IMP dehydrogenase activity
APASM_2253	COG1994	Peptidase M50
APASM_2255	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2256	COG2197	response regulator
APASM_2263	COG1222	aaa ATPase
APASM_2264	COG2197	response regulator
APASM_2265	COG4585	Histidine kinase
APASM_2273	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
APASM_2274	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
APASM_2275	COG4221	oxidoreductase activity
APASM_2277	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
APASM_2277	COG1672	PFAM Archaeal ATPase
APASM_2279	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
APASM_2282	COG2378	regulation of single-species biofilm formation
APASM_2283	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APASM_2293	COG3706	GGDEF domain
APASM_2299	COG2357	RelA SpoT domain protein
APASM_2303	COG1846	Transcriptional regulator
APASM_2304	COG0714	Associated with various cellular activities
APASM_2306	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_2310	COG0187	DNA topoisomerase II activity
APASM_2315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APASM_2316	COG1716	ATPase activity
APASM_2316	COG5001	Diguanylate cyclase
APASM_2320	COG3845	ABC transporter
APASM_2326	COG1940	carbohydrate kinase activity
APASM_2329	COG0277	FAD linked oxidase domain protein
APASM_2337	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APASM_2338	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_2339	COG2205	protein histidine kinase activity
APASM_2342	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APASM_2344	COG0745	RESPONSE REGULATOR receiver
APASM_2346	COG0745	RESPONSE REGULATOR receiver
APASM_2348	COG2201	protein-glutamate methylesterase activity
APASM_2351	COG0835	chemotaxis
APASM_2352	COG2198	Histidine kinase
APASM_2352	COG0643	Histidine kinase
APASM_2356	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APASM_2358	COG1987	bacterial-type flagellum assembly
APASM_2359	COG1338	Plays a role in the flagellum-specific transport system
APASM_2364	COG1360	Flagellar Motor Protein
APASM_2365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APASM_2367	COG4786	Flagellar basal body rod
APASM_2370	COG0741	lytic transglycosylase activity
APASM_2372	COG1157	protein secretion by the type III secretion system
APASM_2374	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APASM_2375	COG1766	The M ring may be actively involved in energy transduction
APASM_2376	COG1677	Flagellar hook-basal body complex protein FliE
APASM_2377	COG1558	bacterial-type flagellum-dependent cell motility
APASM_2380	COG1516	flagellar protein fliS
APASM_2385	COG1256	bacterial-type flagellum assembly
APASM_2385	COG4786	Flagellar basal body rod
APASM_2387	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
APASM_2388	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APASM_2394	COG5002	protein histidine kinase activity
APASM_2396	COG0745	RESPONSE REGULATOR receiver
APASM_2396	COG2205	protein histidine kinase activity
APASM_2396	COG4191	Histidine kinase
APASM_2402	COG1846	Transcriptional regulator
APASM_2406	COG4251	negative regulation of phosphorylation
APASM_2410	COG1522	sequence-specific DNA binding
APASM_2411	COG2814	Major facilitator Superfamily
APASM_2417	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2419	COG0326	Molecular chaperone. Has ATPase activity
APASM_2422	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2430	COG1609	Transcriptional regulator
APASM_2432	COG1175	transmembrane transport
APASM_2433	COG0395	ABC-type sugar transport system, permease component
APASM_2436	COG2197	response regulator
APASM_2443	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APASM_2449	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2454	COG0277	FAD linked oxidase domain protein
APASM_2463	COG0420	3'-5' exonuclease activity
APASM_2467	COG0604	alcohol dehydrogenase
APASM_2469	COG2124	cytochrome p450
APASM_2472	COG2119	membrane
APASM_2480	COG0747	negative chemotaxis
APASM_2482	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_2487	COG0745	RESPONSE REGULATOR receiver
APASM_2488	COG2205	protein histidine kinase activity
APASM_2492	COG1802	Transcriptional regulator
APASM_2500	COG1335	isochorismatase
APASM_2513	COG2124	cytochrome p450
APASM_2518	COG1819	glycosyl
APASM_2520	COG1132	(ABC) transporter
APASM_2525	COG3795	YCII-related domain
APASM_2526	COG4941	Belongs to the sigma-70 factor family
APASM_2534	COG0714	Associated with various cellular activities
APASM_2535	COG3552	Protein containing von Willebrand factor type A (VWA) domain
APASM_2542	COG0384	phenazine biosynthesis protein PhzF
APASM_2545	COG3903	Transcriptional regulator
APASM_2545	COG3629	intracellular signal transduction
APASM_2553	COG0515	serine threonine protein kinase
APASM_2556	COG1653	transport
APASM_2558	COG2124	cytochrome p450
APASM_2560	COG2814	Major facilitator Superfamily
APASM_2562	COG4581	dead DEAH box helicase
APASM_2572	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APASM_2576	COG0477	Major facilitator Superfamily
APASM_2578	COG1612	heme a metabolic process
APASM_2581	COG5001	Diguanylate cyclase
APASM_2601	COG0395	ABC-type sugar transport system, permease component
APASM_2605	COG1609	Transcriptional regulator
APASM_2607	COG1595	DNA-templated transcription, initiation
APASM_2619	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APASM_2621	COG0477	Major facilitator Superfamily
APASM_2632	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2633	COG1309	transcriptional regulator
APASM_2634	COG3384	dioxygenase
APASM_2635	COG0702	epimerase
APASM_2640	COG0488	(ABC) transporter
APASM_2643	COG0640	Transcriptional regulator
APASM_2644	COG0346	lactoylglutathione lyase activity
APASM_2649	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_2651	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_2655	COG2205	protein histidine kinase activity
APASM_2657	COG1253	flavin adenine dinucleotide binding
APASM_2659	COG0604	alcohol dehydrogenase
APASM_2667	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_2669	COG2376	Dihydroxyacetone kinase
APASM_2670	COG0698	ribose 5-phosphate isomerase
APASM_2671	COG0149	triose-phosphate isomerase activity
APASM_2672	COG1082	Xylose isomerase domain protein TIM barrel
APASM_2673	COG2084	Dehydrogenase
APASM_2676	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APASM_2684	COG1834	amidinotransferase
APASM_2687	COG0475	glutathione-regulated potassium exporter activity
APASM_2688	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APASM_2700	COG1131	(ABC) transporter
APASM_2704	COG0477	Major facilitator Superfamily
APASM_2709	COG2267	carboxylic ester hydrolase activity
APASM_2711	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_2715	COG1509	lysine 2,3-aminomutase activity
APASM_2720	COG3321	synthase
APASM_2720	COG0604	alcohol dehydrogenase
APASM_2724	COG1136	(ABC) transporter
APASM_2733	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_2734	COG1120	ATPase activity
APASM_2742	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APASM_2745	COG1120	ATPase activity
APASM_2746	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_2747	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_2748	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APASM_2749	COG2375	cellular response to nickel ion
APASM_2750	COG3433	isochorismatase activity
APASM_2750	COG1535	isochorismatase
APASM_2751	COG1535	isochorismatase
APASM_2751	COG3433	isochorismatase activity
APASM_2752	COG1021	2,3-dihydroxybenzoate-AMP ligase
APASM_2753	COG1169	isochorismate synthase
APASM_2754	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2756	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_2757	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APASM_2759	COG3655	Transcriptional regulator
APASM_2762	COG4585	Histidine kinase
APASM_2763	COG2197	response regulator
APASM_2769	COG0148	phosphopyruvate hydratase activity
APASM_2772	COG4152	abc transporter atp-binding protein
APASM_2773	COG1668	transmembrane transport
APASM_2784	COG0477	Major facilitator Superfamily
APASM_2786	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
APASM_2787	COG2197	response regulator
APASM_2789	COG0577	efflux transmembrane transporter activity
APASM_2789	COG1136	(ABC) transporter
APASM_2803	COG0456	acetyltransferase
APASM_2804	COG1309	transcriptional regulator
APASM_2805	COG1132	(ABC) transporter
APASM_2808	COG0738	Major facilitator superfamily
APASM_2810	COG0583	DNA-binding transcription factor activity
APASM_2811	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_2813	COG1012	belongs to the aldehyde dehydrogenase family
APASM_2817	COG2409	Drug exporters of the RND superfamily
APASM_2836	COG2197	response regulator
APASM_2844	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APASM_2845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APASM_2848	COG1131	(ABC) transporter
APASM_2850	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2850	COG0604	alcohol dehydrogenase
APASM_2850	COG3321	synthase
APASM_2856	COG1653	transport
APASM_2858	COG3833	ABC-type maltose transport systems, permease component
APASM_2861	COG3507	Belongs to the glycosyl hydrolase 43 family
APASM_2863	COG0596	Alpha beta hydrolase
APASM_2866	COG2197	response regulator
APASM_2870	COG0028	Belongs to the TPP enzyme family
APASM_2871	COG1473	amidohydrolase
APASM_2872	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_2875	COG1177	transmembrane transport
APASM_2876	COG1176	ABC-type spermidine putrescine transport system, permease component I
APASM_2877	COG3842	ATPase activity
APASM_2879	COG4221	oxidoreductase activity
APASM_2883	COG1309	transcriptional regulator
APASM_2889	COG3209	COG3209 Rhs family protein
APASM_2893	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_2894	COG1120	ATPase activity
APASM_2901	COG0135	phosphoribosylanthranilate isomerase activity
APASM_2909	COG3903	Transcriptional regulator
APASM_2909	COG3629	intracellular signal transduction
APASM_2912	COG2076	Multidrug Resistance protein
APASM_2921	COG0642	Histidine kinase
APASM_2924	COG1309	transcriptional regulator
APASM_2925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_2935	COG4251	negative regulation of phosphorylation
APASM_2937	COG0784	Response regulator, receiver
APASM_2941	COG1733	regulation of RNA biosynthetic process
APASM_2942	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_2944	COG0395	ABC-type sugar transport system, permease component
APASM_2948	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APASM_2951	COG3629	intracellular signal transduction
APASM_2951	COG3903	Transcriptional regulator
APASM_2958	COG1222	aaa ATPase
APASM_2977	COG3903	Transcriptional regulator
APASM_2977	COG3629	intracellular signal transduction
APASM_2989	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APASM_2991	COG3831	ATPase activity
APASM_2992	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APASM_2997	COG0673	inositol 2-dehydrogenase activity
APASM_3000	COG0494	nUDIX hydrolase
APASM_3001	COG1309	transcriptional regulator
APASM_3009	COG1175	transmembrane transport
APASM_3011	COG1501	Belongs to the glycosyl hydrolase 31 family
APASM_3013	COG1609	Transcriptional regulator
APASM_3018	COG4106	trans-aconitate 2-methyltransferase activity
APASM_3022	COG2318	DinB family
APASM_3025	COG1309	transcriptional regulator
APASM_3027	COG0789	Transcriptional regulator
APASM_3028	COG2197	response regulator
APASM_3030	COG0577	efflux transmembrane transporter activity
APASM_3030	COG1136	(ABC) transporter
APASM_3031	COG1136	(ABC) transporter
APASM_3031	COG0577	efflux transmembrane transporter activity
APASM_3041	COG2375	cellular response to nickel ion
APASM_3042	COG3629	intracellular signal transduction
APASM_3042	COG3903	Transcriptional regulator
APASM_3048	COG3831	ATPase activity
APASM_3055	COG0483	inositol monophosphate 1-phosphatase activity
APASM_3057	COG1132	(ABC) transporter
APASM_3058	COG1132	(ABC) transporter
APASM_3070	COG1556	Lactate utilization protein
APASM_3071	COG1139	Iron-sulfur cluster binding protein
APASM_3072	COG0247	lactate metabolic process
APASM_3073	COG2188	Transcriptional regulator
APASM_3075	COG1129	ABC transporter
APASM_3077	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_3080	COG3347	Dehydrogenase
APASM_3080	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3081	COG1070	Carbohydrate kinase
APASM_3083	COG0402	S-adenosylhomocysteine deaminase activity
APASM_3085	COG0583	DNA-binding transcription factor activity
APASM_3088	COG3851	Histidine kinase
APASM_3090	COG1595	DNA-templated transcription, initiation
APASM_3093	COG2124	cytochrome p450
APASM_3101	COG0601	transmembrane transport
APASM_3102	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_3103	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APASM_3105	COG0367	asparagine synthase
APASM_3109	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APASM_3111	COG1012	belongs to the aldehyde dehydrogenase family
APASM_3113	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APASM_3123	COG0583	DNA-binding transcription factor activity
APASM_3126	COG2814	Major facilitator Superfamily
APASM_3134	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APASM_3135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APASM_3139	COG3345	alpha-galactosidase
APASM_3142	COG0644	oxidoreductase
APASM_3143	COG0156	8-amino-7-oxononanoate synthase activity
APASM_3145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_3147	COG3629	intracellular signal transduction
APASM_3147	COG3903	Transcriptional regulator
APASM_3149	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_3150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_3156	COG0656	L-ascorbic acid biosynthetic process
APASM_3157	COG0583	DNA-binding transcription factor activity
APASM_3160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APASM_3162	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APASM_3163	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APASM_3169	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3171	COG1830	Aldolase
APASM_3172	COG1063	alcohol dehydrogenase
APASM_3175	COG0659	secondary active sulfate transmembrane transporter activity
APASM_3183	COG1408	metallophosphoesterase
APASM_3188	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APASM_3188	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APASM_3189	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APASM_3191	COG2856	Zn peptidase
APASM_3193	COG2409	Drug exporters of the RND superfamily
APASM_3202	COG1309	transcriptional regulator
APASM_3204	COG1132	(ABC) transporter
APASM_3205	COG0475	glutathione-regulated potassium exporter activity
APASM_3212	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_3215	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_3216	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_3221	COG3795	YCII-related domain
APASM_3225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APASM_3231	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3234	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APASM_3234	COG2124	cytochrome p450
APASM_3238	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APASM_3246	COG3507	Belongs to the glycosyl hydrolase 43 family
APASM_3251	COG4585	Histidine kinase
APASM_3252	COG2197	response regulator
APASM_3258	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3259	COG0667	Aldo Keto reductase
APASM_3263	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APASM_3264	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APASM_3281	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_3288	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APASM_3291	COG0546	phosphoglycolate phosphatase activity
APASM_3292	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_3309	COG3693	PFAM glycoside hydrolase, family 10
APASM_3309	COG3509	depolymerase
APASM_3312	COG1609	Transcriptional regulator
APASM_3317	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3320	COG4585	Histidine kinase
APASM_3323	COG1073	alpha beta
APASM_3324	COG0714	Associated with various cellular activities
APASM_3335	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3342	COG1609	Transcriptional regulator
APASM_3344	COG1733	regulation of RNA biosynthetic process
APASM_3349	COG2267	carboxylic ester hydrolase activity
APASM_3355	COG2261	transglycosylase associated protein
APASM_3357	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APASM_3363	COG1064	alcohol dehydrogenase
APASM_3366	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APASM_3369	COG0667	Aldo Keto reductase
APASM_3372	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APASM_3373	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APASM_3380	COG0028	Belongs to the TPP enzyme family
APASM_3384	COG0583	DNA-binding transcription factor activity
APASM_3387	COG1233	COG1233 Phytoene dehydrogenase and related
APASM_3393	COG2249	NAD(P)H dehydrogenase (quinone) activity
APASM_3400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APASM_3401	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APASM_3403	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APASM_3404	COG1607	acyl-coa hydrolase
APASM_3408	COG0463	Glycosyl transferase, family 2
APASM_3414	COG1435	thymidine kinase activity
APASM_3417	COG2270	Major facilitator Superfamily
APASM_3418	COG3706	GGDEF domain
APASM_3421	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
APASM_3427	COG0640	Transcriptional regulator
APASM_3428	COG0798	PFAM Bile acid sodium symporter
APASM_3439	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3443	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_3444	COG1349	DNA-binding transcription factor activity
APASM_3446	COG5002	protein histidine kinase activity
APASM_3446	COG2176	DNA-directed DNA polymerase activity
APASM_3454	COG1619	proteins homologs of microcin C7 resistance protein MccF
APASM_3455	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3462	COG1960	acyl-CoA dehydrogenase activity
APASM_3464	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APASM_3466	COG0747	negative chemotaxis
APASM_3468	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_3470	COG1609	Transcriptional regulator
APASM_3475	COG4974	Belongs to the 'phage' integrase family
APASM_3488	COG0667	Aldo Keto reductase
APASM_3496	COG2755	lipolytic protein G-D-S-L family
APASM_3503	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APASM_3505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_3507	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APASM_3509	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_3512	COG1846	Transcriptional regulator
APASM_3516	COG2130	NADP-dependent
APASM_3518	COG1643	Atp-dependent helicase
APASM_3522	COG1968	undecaprenyl-diphosphatase activity
APASM_3523	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_3524	COG0667	Aldo Keto reductase
APASM_3531	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APASM_3533	COG2909	trisaccharide binding
APASM_3534	COG1414	Transcriptional regulator
APASM_3546	COG2814	Major facilitator Superfamily
APASM_3552	COG1216	Glycosyl transferase, family 2
APASM_3552	COG0438	transferase activity, transferring glycosyl groups
APASM_3558	COG1316	TRANSCRIPTIONal
APASM_3560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_3563	COG1404	Belongs to the peptidase S8 family
APASM_3564	COG1309	transcriptional regulator
APASM_3567	COG4552	Acetyltransferase involved in intracellular survival and related
APASM_3568	COG3507	Belongs to the glycosyl hydrolase 43 family
APASM_3571	COG3629	intracellular signal transduction
APASM_3571	COG3903	Transcriptional regulator
APASM_3573	COG2197	response regulator
APASM_3575	COG2124	cytochrome p450
APASM_3580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_3581	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_3589	COG0310	cobalt ion transport
APASM_3595	COG2223	nitrite transmembrane transporter activity
APASM_3597	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
APASM_3597	COG2508	Transcriptional regulator
APASM_3598	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APASM_3599	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APASM_3602	COG2124	cytochrome p450
APASM_3605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_3609	COG1132	(ABC) transporter
APASM_3616	COG1136	(ABC) transporter
APASM_3621	COG1012	belongs to the aldehyde dehydrogenase family
APASM_3628	COG0110	maltose O-acetyltransferase activity
APASM_3634	COG2226	methyltransferase
APASM_3646	COG1132	(ABC) transporter
APASM_3659	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_3661	COG1309	transcriptional regulator
APASM_3665	COG3030	protein affecting phage T7 exclusion by the F plasmid
APASM_3674	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APASM_3680	COG3395	kinase activity
APASM_3681	COG0235	Class ii aldolase
APASM_3682	COG1349	DNA-binding transcription factor activity
APASM_3685	COG0387	Pfam Sodium calcium exchanger
APASM_3687	COG3903	Transcriptional regulator
APASM_3687	COG3629	intracellular signal transduction
APASM_3690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_3690	COG2205	protein histidine kinase activity
APASM_3690	COG2198	Histidine kinase
APASM_3690	COG0784	Response regulator, receiver
APASM_3692	COG2172	sigma factor antagonist activity
APASM_3693	COG1366	Belongs to the anti-sigma-factor antagonist family
APASM_3694	COG1366	Belongs to the anti-sigma-factor antagonist family
APASM_3697	COG2072	flavoprotein involved in K transport
APASM_3708	COG3537	Alpha-1,2-mannosidase
APASM_3712	COG0789	Transcriptional regulator
APASM_3722	COG3210	domain, Protein
APASM_3740	COG3345	alpha-galactosidase
APASM_3744	COG1733	regulation of RNA biosynthetic process
APASM_3746	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APASM_3747	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_3750	COG1959	2 iron, 2 sulfur cluster binding
APASM_3751	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APASM_3751	COG1017	nitric oxide dioxygenase activity
APASM_3763	COG0667	Aldo Keto reductase
APASM_3770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APASM_3771	COG1021	2,3-dihydroxybenzoate-AMP ligase
APASM_3773	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APASM_3774	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APASM_3777	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_3782	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_3784	COG0673	inositol 2-dehydrogenase activity
APASM_3790	COG1309	transcriptional regulator
APASM_3793	COG3537	Alpha-1,2-mannosidase
APASM_3794	COG0596	Alpha beta hydrolase
APASM_3799	COG2814	Major facilitator Superfamily
APASM_3800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APASM_3811	COG2755	lipolytic protein G-D-S-L family
APASM_3813	COG0745	RESPONSE REGULATOR receiver
APASM_3815	COG0582	viral genome integration into host DNA
APASM_3823	COG0602	queuosine metabolic process
APASM_3824	COG0720	synthase
APASM_3829	COG0438	transferase activity, transferring glycosyl groups
APASM_3830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APASM_3831	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APASM_3833	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APASM_3835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APASM_3839	COG1957	nucleoside hydrolase
APASM_3843	COG0134	indole-3-glycerol-phosphate synthase activity
APASM_3847	COG2319	Wd-40 repeat
APASM_3847	COG4249	Peptidase C14 caspase catalytic subunit p20
APASM_3850	COG0582	viral genome integration into host DNA
APASM_3879	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_3879	COG4221	oxidoreductase activity
APASM_3879	COG3321	synthase
APASM_3879	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3887	COG0583	DNA-binding transcription factor activity
APASM_3901	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_3904	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APASM_3905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_3914	COG2192	nodulation
APASM_3921	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APASM_3940	COG3866	Pectate lyase
APASM_3941	COG3509	depolymerase
APASM_3947	COG1064	alcohol dehydrogenase
APASM_3956	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APASM_3957	COG1309	transcriptional regulator
APASM_3958	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3961	COG3226	Transcriptional regulator
APASM_3962	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APASM_3964	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_3968	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_3970	COG0435	Glutathione S-transferase
APASM_3975	COG0596	Alpha beta hydrolase
APASM_3976	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APASM_3981	COG3851	Histidine kinase
APASM_3982	COG2197	response regulator
APASM_3993	COG0673	inositol 2-dehydrogenase activity
APASM_3996	COG4335	DNA alkylation repair
APASM_3997	COG0596	Alpha beta hydrolase
APASM_3998	COG0745	RESPONSE REGULATOR receiver
APASM_3999	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APASM_4008	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_4015	COG0515	serine threonine protein kinase
APASM_4020	COG0492	ferredoxin-NADP+ reductase activity
APASM_4023	COG0475	glutathione-regulated potassium exporter activity
APASM_4035	COG1136	(ABC) transporter
APASM_4037	COG2197	response regulator
APASM_4038	COG3851	Histidine kinase
APASM_4048	COG3284	Transcriptional regulator
APASM_4051	COG5002	protein histidine kinase activity
APASM_4052	COG0745	RESPONSE REGULATOR receiver
APASM_4055	COG0577	efflux transmembrane transporter activity
APASM_4060	COG2345	Transcriptional regulator
APASM_4068	COG1960	acyl-CoA dehydrogenase activity
APASM_4070	COG2814	Major facilitator Superfamily
APASM_4076	COG0596	Alpha beta hydrolase
APASM_4082	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APASM_4084	COG0300	oxidoreductase activity
APASM_4087	COG2124	cytochrome p450
APASM_4088	COG2207	Transcriptional regulator
APASM_4099	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_4100	COG1024	Enoyl-CoA hydratase
APASM_4104	COG1917	Cupin 2, conserved barrel domain protein
APASM_4104	COG4977	sequence-specific DNA binding
APASM_4114	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APASM_4116	COG1609	Transcriptional regulator
APASM_4118	COG4948	Mandelate Racemase Muconate Lactonizing
APASM_4123	COG2205	protein histidine kinase activity
APASM_4124	COG0745	RESPONSE REGULATOR receiver
APASM_4132	COG2267	carboxylic ester hydrolase activity
APASM_4141	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APASM_4143	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APASM_4147	COG1414	Transcriptional regulator
APASM_4148	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APASM_4155	COG3340	Belongs to the peptidase S51 family
APASM_4165	COG3629	intracellular signal transduction
APASM_4165	COG3903	Transcriptional regulator
APASM_4166	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
APASM_4168	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APASM_4170	COG4221	oxidoreductase activity
APASM_4174	COG0840	transmembrane signaling receptor activity
APASM_4176	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
APASM_4177	COG1404	Belongs to the peptidase S8 family
APASM_4178	COG1404	Belongs to the peptidase S8 family
APASM_4179	COG3266	domain, Protein
APASM_4179	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
APASM_4179	COG4932	domain protein
APASM_4186	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_4187	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APASM_4189	COG3486	L-lysine 6-monooxygenase (NADPH) activity
APASM_4191	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_4191	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_4193	COG0697	spore germination
APASM_4194	COG0644	oxidoreductase
APASM_4198	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_4208	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
APASM_4210	COG0659	secondary active sulfate transmembrane transporter activity
APASM_4213	COG2255	four-way junction helicase activity
APASM_4223	COG3467	pyridoxamine 5'-phosphate
APASM_4224	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_4225	COG2124	cytochrome p450
APASM_4227	COG0726	polysaccharide deacetylase
APASM_4228	COG0439	Biotin carboxylase
APASM_4230	COG0395	ABC-type sugar transport system, permease component
APASM_4231	COG1175	transmembrane transport
APASM_4232	COG2182	Extracellular solute-binding protein
APASM_4234	COG0667	Aldo Keto reductase
APASM_4238	COG0300	oxidoreductase activity
APASM_4245	COG0110	maltose O-acetyltransferase activity
APASM_4248	COG1181	Belongs to the D-alanine--D-alanine ligase family
APASM_4251	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APASM_4252	COG2197	response regulator
APASM_4253	COG3850	Histidine kinase
APASM_4258	COG3831	ATPase activity
APASM_4267	COG1902	pentaerythritol trinitrate reductase activity
APASM_4270	COG0534	Mate efflux family protein
APASM_4273	COG0640	Transcriptional regulator
APASM_4276	COG0640	Transcriptional regulator
APASM_4277	COG0672	)-iron permease
APASM_4279	COG2837	iron assimilation
APASM_4282	COG0596	Alpha beta hydrolase
APASM_4283	COG1120	ATPase activity
APASM_4284	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_4285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_4290	COG1982	Orn Lys Arg decarboxylase major
APASM_4298	COG0277	FAD linked oxidase domain protein
APASM_4302	COG0583	DNA-binding transcription factor activity
APASM_4303	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_4304	COG1960	acyl-CoA dehydrogenase activity
APASM_4309	COG0243	molybdopterin cofactor binding
APASM_4315	COG4172	Belongs to the ABC transporter superfamily
APASM_4324	COG0784	Response regulator, receiver
APASM_4328	COG1522	sequence-specific DNA binding
APASM_4330	COG0861	Integral membrane protein TerC family
APASM_4332	COG1309	transcriptional regulator
APASM_4334	COG2807	transmembrane transport
APASM_4336	COG0475	glutathione-regulated potassium exporter activity
APASM_4338	COG2814	Major facilitator Superfamily
APASM_4346	COG0745	RESPONSE REGULATOR receiver
APASM_4348	COG2986	histidine ammonia-lyase
APASM_4360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APASM_4363	COG1960	acyl-CoA dehydrogenase activity
APASM_4366	COG0183	Belongs to the thiolase family
APASM_4367	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_4367	COG1024	Enoyl-CoA hydratase
APASM_4368	COG1309	transcriptional regulator
APASM_4371	COG2010	Cytochrome c
APASM_4371	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APASM_4372	COG2080	2 iron, 2 sulfur cluster binding
APASM_4374	COG1201	RNA secondary structure unwinding
APASM_4378	COG0556	nucleotide-excision repair
APASM_4380	COG0142	geranyltranstransferase activity
APASM_4381	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APASM_4382	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APASM_4384	COG2175	clavaminate synthase activity
APASM_4387	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APASM_4394	COG1309	transcriptional regulator
APASM_4397	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_4398	COG1309	transcriptional regulator
APASM_4399	COG0789	Transcriptional regulator
APASM_4403	COG3831	ATPase activity
APASM_4406	COG0438	transferase activity, transferring glycosyl groups
APASM_4414	COG0254	rRNA binding
APASM_4416	COG0753	catalase activity
APASM_4417	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APASM_4417	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_4418	COG2258	MOSC domain
APASM_4422	COG0604	alcohol dehydrogenase
APASM_4424	COG0604	alcohol dehydrogenase
APASM_4432	COG2197	response regulator
APASM_4433	COG4585	Histidine kinase
APASM_4436	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APASM_4437	COG1121	(ABC) transporter
APASM_4438	COG0803	Belongs to the bacterial solute-binding protein 9 family
APASM_4448	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APASM_4454	COG3629	intracellular signal transduction
APASM_4459	COG0730	response to heat
APASM_4462	COG4221	oxidoreductase activity
APASM_4471	COG1022	Amp-dependent synthetase and ligase
APASM_4474	COG1309	transcriptional regulator
APASM_4475	COG0778	Nitroreductase
APASM_4482	COG1063	alcohol dehydrogenase
APASM_4488	COG1509	lysine 2,3-aminomutase activity
APASM_4490	COG0644	oxidoreductase
APASM_4491	COG3486	L-lysine 6-monooxygenase (NADPH) activity
APASM_4492	COG2808	Putative FMN-binding domain
APASM_4502	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APASM_4503	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APASM_4504	COG0165	Argininosuccinate lyase
APASM_4511	COG3973	AAA domain
APASM_4512	COG2409	Drug exporters of the RND superfamily
APASM_4514	COG2197	response regulator
APASM_4515	COG2205	protein histidine kinase activity
APASM_4516	COG0745	RESPONSE REGULATOR receiver
APASM_4537	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_4569	COG2124	cytochrome p450
APASM_4571	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APASM_4578	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
APASM_4583	COG1278	Cold shock
APASM_4610	COG3903	Transcriptional regulator
APASM_4610	COG3629	intracellular signal transduction
APASM_4612	COG2124	cytochrome p450
APASM_4616	COG0300	oxidoreductase activity
APASM_4617	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
APASM_4617	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_4621	COG2272	Belongs to the type-B carboxylesterase lipase family
APASM_4623	COG1609	Transcriptional regulator
APASM_4625	COG1175	transmembrane transport
APASM_4634	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_4635	COG1309	transcriptional regulator
APASM_4637	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_4643	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_4646	COG0583	DNA-binding transcription factor activity
APASM_4647	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APASM_4648	COG3250	beta-galactosidase activity
APASM_4650	COG2909	trisaccharide binding
APASM_4656	COG0438	transferase activity, transferring glycosyl groups
APASM_4669	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APASM_4673	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_4717	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APASM_4723	COG2755	lipolytic protein G-D-S-L family
APASM_4725	COG2197	response regulator
APASM_4730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_4744	COG1309	transcriptional regulator
APASM_4745	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_4746	COG1012	belongs to the aldehyde dehydrogenase family
APASM_4763	COG0702	epimerase
APASM_4766	COG1733	regulation of RNA biosynthetic process
APASM_4774	COG0006	proline dipeptidase activity
APASM_4777	COG0444	Belongs to the ABC transporter superfamily
APASM_4780	COG0747	negative chemotaxis
APASM_4781	COG1802	Transcriptional regulator
APASM_4783	COG3938	Belongs to the proline racemase family
APASM_4784	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APASM_4788	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APASM_4790	COG1609	Transcriptional regulator
APASM_4792	COG0402	S-adenosylhomocysteine deaminase activity
APASM_4799	COG1131	(ABC) transporter
APASM_4801	COG1595	DNA-templated transcription, initiation
APASM_4804	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APASM_4806	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APASM_4823	COG0443	Heat shock 70 kDa protein
APASM_4827	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APASM_4836	COG1121	(ABC) transporter
APASM_4837	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APASM_4839	COG0523	cobalamin synthesis protein
APASM_4849	COG1120	ATPase activity
APASM_4850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_4853	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APASM_4854	COG0840	transmembrane signaling receptor activity
APASM_4856	COG0583	DNA-binding transcription factor activity
APASM_4858	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_4860	COG1309	transcriptional regulator
APASM_4861	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_4862	COG2391	methyltransferase activity
APASM_4866	COG0477	Major facilitator Superfamily
APASM_4867	COG1309	transcriptional regulator
APASM_4877	COG2018	Roadblock/LC7 domain
APASM_4881	COG0673	inositol 2-dehydrogenase activity
APASM_4884	COG1929	Belongs to the glycerate kinase type-1 family
APASM_4894	COG2124	cytochrome p450
APASM_4896	COG1216	Glycosyl transferase, family 2
APASM_4898	COG0702	epimerase
APASM_4901	COG1819	glycosyl
APASM_4904	COG1819	glycosyl
APASM_4906	COG0515	serine threonine protein kinase
APASM_4909	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APASM_4910	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_4914	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APASM_4915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APASM_4916	COG1012	belongs to the aldehyde dehydrogenase family
APASM_4918	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_4919	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APASM_4920	COG1132	(ABC) transporter
APASM_4921	COG1309	transcriptional regulator
APASM_4924	COG3386	PFAM SMP-30 Gluconolaconase
APASM_4925	COG2072	flavoprotein involved in K transport
APASM_4935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APASM_4936	COG0494	nUDIX hydrolase
APASM_4938	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_4940	COG1414	Transcriptional regulator
APASM_4941	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APASM_4943	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_4945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_4949	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APASM_4951	COG0583	DNA-binding transcription factor activity
APASM_4952	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APASM_4952	COG0515	serine threonine protein kinase
APASM_4954	COG1902	pentaerythritol trinitrate reductase activity
APASM_4961	COG1802	Transcriptional regulator
APASM_4963	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_4964	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_4967	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APASM_4968	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_4976	COG2022	thiamine diphosphate biosynthetic process
APASM_4979	COG2208	phosphoserine phosphatase activity
APASM_4979	COG2770	Histidine kinase
APASM_4981	COG2365	Tyrosine phosphatase family
APASM_4983	COG2755	lipolytic protein G-D-S-L family
APASM_4984	COG3835	regulator
APASM_4990	COG1929	Belongs to the glycerate kinase type-1 family
APASM_4992	COG2205	protein histidine kinase activity
APASM_4996	COG0477	Major facilitator Superfamily
APASM_4998	COG0583	DNA-binding transcription factor activity
APASM_5001	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APASM_5005	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APASM_5014	COG0463	Glycosyl transferase, family 2
APASM_5017	COG0438	transferase activity, transferring glycosyl groups
APASM_5022	COG1472	Belongs to the glycosyl hydrolase 3 family
APASM_5024	COG2267	carboxylic ester hydrolase activity
APASM_5025	COG3693	PFAM glycoside hydrolase, family 10
APASM_5028	COG0500	methyltransferase
APASM_5031	COG2409	Drug exporters of the RND superfamily
APASM_5035	COG1253	flavin adenine dinucleotide binding
APASM_5041	COG0009	L-threonylcarbamoyladenylate synthase
APASM_5045	COG2197	response regulator
APASM_5051	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APASM_5052	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_5055	COG1522	sequence-specific DNA binding
APASM_5056	COG2340	Cysteine-rich secretory protein family
APASM_5057	COG2205	protein histidine kinase activity
APASM_5066	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_5067	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_5075	COG0463	Glycosyl transferase, family 2
APASM_5077	COG1064	alcohol dehydrogenase
APASM_5078	COG1309	transcriptional regulator
APASM_5080	COG2855	membrane
APASM_5082	COG0745	RESPONSE REGULATOR receiver
APASM_5083	COG4251	negative regulation of phosphorylation
APASM_5084	COG0784	Response regulator, receiver
APASM_5091	COG3973	AAA domain
APASM_5094	COG1309	transcriptional regulator
APASM_5095	COG0300	oxidoreductase activity
APASM_5097	COG0823	Involved in the tonB-independent uptake of proteins
APASM_5099	COG3973	AAA domain
APASM_5101	COG1120	ATPase activity
APASM_5102	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_5103	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APASM_5105	COG1063	alcohol dehydrogenase
APASM_5106	COG0477	Major facilitator Superfamily
APASM_5107	COG0246	Mannitol dehydrogenase
APASM_5114	COG4607	ABC-type enterochelin transport system periplasmic component
APASM_5115	COG3486	L-lysine 6-monooxygenase (NADPH) activity
APASM_5116	COG1132	(ABC) transporter
APASM_5117	COG1132	(ABC) transporter
APASM_5118	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APASM_5124	COG0583	DNA-binding transcription factor activity
APASM_5130	COG1414	Transcriptional regulator
APASM_5131	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APASM_5133	COG2267	carboxylic ester hydrolase activity
APASM_5134	COG3485	protocatechuate 3,4-dioxygenase
APASM_5135	COG3485	protocatechuate 3,4-dioxygenase
APASM_5136	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APASM_5137	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APASM_5141	COG2208	phosphoserine phosphatase activity
APASM_5141	COG2770	Histidine kinase
APASM_5143	COG5002	protein histidine kinase activity
APASM_5143	COG0784	Response regulator, receiver
APASM_5146	COG0248	Ppx GppA phosphatase
APASM_5150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APASM_5153	COG1609	Transcriptional regulator
APASM_5154	COG1619	proteins homologs of microcin C7 resistance protein MccF
APASM_5155	COG0300	oxidoreductase activity
APASM_5156	COG1309	transcriptional regulator
APASM_5167	COG1609	Transcriptional regulator
APASM_5170	COG0739	heme binding
APASM_5171	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APASM_5172	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APASM_5174	COG0596	Alpha beta hydrolase
APASM_5176	COG0583	DNA-binding transcription factor activity
APASM_5178	COG1349	DNA-binding transcription factor activity
APASM_5179	COG4821	SIS domain
APASM_5180	COG1132	(ABC) transporter
APASM_5182	COG1024	Enoyl-CoA hydratase
APASM_5184	COG0488	(ABC) transporter
APASM_5185	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_5191	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APASM_5194	COG3706	GGDEF domain
APASM_5197	COG2151	metal-sulfur cluster biosynthetic enzyme
APASM_5198	COG0822	iron-sulfur transferase activity
APASM_5200	COG0396	ATPase activity
APASM_5208	COG1752	Esterase of the alpha-beta hydrolase superfamily
APASM_5211	COG1131	(ABC) transporter
APASM_5220	COG2018	Roadblock/LC7 domain
APASM_5223	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_5234	COG0109	protoheme IX farnesyltransferase activity
APASM_5236	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APASM_5237	COG0166	Belongs to the GPI family
APASM_5240	COG0363	glucosamine-6-phosphate deaminase activity
APASM_5241	COG4585	Histidine kinase
APASM_5245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APASM_5246	COG0149	triose-phosphate isomerase activity
APASM_5247	COG0126	phosphoglycerate kinase activity
APASM_5248	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APASM_5252	COG1481	regulation of sporulation
APASM_5254	COG1660	Displays ATPase and GTPase activities
APASM_5255	COG0322	excinuclease ABC activity
APASM_5264	COG2234	aminopeptidase activity
APASM_5266	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APASM_5267	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APASM_5267	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APASM_5274	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APASM_5275	COG0242	peptide deformylase activity
APASM_5282	COG0405	Gamma-glutamyltransferase
APASM_5285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APASM_5287	COG1758	RNA polymerase activity
APASM_5288	COG0194	GDP metabolic process
APASM_5290	COG0284	orotidine-5'-phosphate decarboxylase activity
APASM_5292	COG0505	Belongs to the CarA family
APASM_5295	COG0540	Belongs to the ATCase OTCase family
APASM_5296	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APASM_5298	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APASM_5299	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APASM_5300	COG0006	proline dipeptidase activity
APASM_5303	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APASM_5304	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APASM_5306	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APASM_5307	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APASM_5309	COG2190	(PTS) system
APASM_5310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APASM_5310	COG1263	PTS System
APASM_5312	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APASM_5312	COG1263	PTS System
APASM_5313	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APASM_5314	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APASM_5316	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APASM_5317	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APASM_5326	COG4581	dead DEAH box helicase
APASM_5327	COG1388	LysM domain
APASM_5329	COG3279	Response regulator of the LytR AlgR family
APASM_5331	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APASM_5332	COG3275	phosphorelay sensor kinase activity
APASM_5342	COG1733	regulation of RNA biosynthetic process
APASM_5346	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APASM_5359	COG0395	ABC-type sugar transport system, permease component
APASM_5363	COG1024	Enoyl-CoA hydratase
APASM_5368	COG2258	MOSC domain
APASM_5369	COG0667	Aldo Keto reductase
APASM_5372	COG1012	belongs to the aldehyde dehydrogenase family
APASM_5372	COG2030	dehydratase
APASM_5376	COG3629	intracellular signal transduction
APASM_5376	COG3903	Transcriptional regulator
APASM_5377	COG2755	lipolytic protein G-D-S-L family
APASM_5377	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APASM_5380	COG1132	(ABC) transporter
APASM_5385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APASM_5386	COG0564	pseudouridine synthase activity
APASM_5396	COG1609	Transcriptional regulator
APASM_5405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APASM_5405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APASM_5409	COG1716	ATPase activity
APASM_5420	COG0667	Aldo Keto reductase
APASM_5430	COG2197	response regulator
APASM_5431	COG2197	response regulator
APASM_5448	COG1222	aaa ATPase
APASM_5457	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APASM_5458	COG1366	Belongs to the anti-sigma-factor antagonist family
APASM_5462	COG4977	sequence-specific DNA binding
APASM_5472	COG2018	Roadblock/LC7 domain
APASM_5474	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APASM_5476	COG1116	anion transmembrane transporter activity
APASM_5476	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APASM_5477	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_5478	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APASM_5480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APASM_5481	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APASM_5484	COG0640	Transcriptional regulator
APASM_5489	COG0504	CTP synthase activity
APASM_5494	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APASM_5497	COG0647	UMP catabolic process
APASM_5499	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APASM_5502	COG2094	Belongs to the DNA glycosylase MPG family
APASM_5503	COG0165	Argininosuccinate lyase
APASM_5504	COG1438	arginine binding
APASM_5507	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APASM_5508	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APASM_5509	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APASM_5510	COG0604	alcohol dehydrogenase
APASM_5511	COG1476	TRANSCRIPTIONal
APASM_5515	COG0072	phenylalanine-tRNA ligase activity
APASM_5515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APASM_5516	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APASM_5517	COG0326	Molecular chaperone. Has ATPase activity
APASM_5519	COG0745	RESPONSE REGULATOR receiver
APASM_5520	COG0642	Histidine kinase
APASM_5521	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APASM_5522	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APASM_5523	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APASM_5524	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APASM_5528	COG3629	intracellular signal transduction
APASM_5528	COG3903	Transcriptional regulator
APASM_5533	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APASM_5534	COG2610	gluconate transmembrane transporter activity
APASM_5538	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APASM_5543	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_5544	COG0640	Transcriptional regulator
APASM_5559	COG5650	phosphatidylinositol metabolic process
APASM_5564	COG0823	Involved in the tonB-independent uptake of proteins
APASM_5564	COG1506	peptidase
APASM_5564	COG4946	Tricorn protease homolog
APASM_5565	COG0861	Integral membrane protein TerC family
APASM_5566	COG1131	(ABC) transporter
APASM_5572	COG0237	dephospho-CoA kinase activity
APASM_5572	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APASM_5574	COG0539	negative regulation of cytoplasmic translation
APASM_5578	COG1511	domain protein
APASM_5579	COG1309	transcriptional regulator
APASM_5582	COG0673	inositol 2-dehydrogenase activity
APASM_5584	COG2050	protein possibly involved in aromatic compounds catabolism
APASM_5586	COG0410	ABC transporter
APASM_5595	COG1832	CoA-binding protein
APASM_5596	COG0251	oxidation-reduction process
APASM_5599	COG1357	PFAM Pentapeptide repeats (8 copies)
APASM_5600	COG0514	ATP-dependent DNA helicase (RecQ)
APASM_5604	COG1937	Protein conserved in bacteria
APASM_5608	COG1595	DNA-templated transcription, initiation
APASM_5609	COG1408	metallophosphoesterase
APASM_5612	COG0778	Nitroreductase
APASM_5613	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APASM_5614	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APASM_5616	COG1566	PFAM secretion protein HlyD family protein
APASM_5620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APASM_5621	COG1960	acyl-CoA dehydrogenase activity
APASM_5623	COG0183	Belongs to the thiolase family
APASM_5624	COG1024	Enoyl-CoA hydratase
APASM_5624	COG1250	3-hydroxyacyl-CoA dehydrogenase
APASM_5630	COG0577	efflux transmembrane transporter activity
APASM_5630	COG1136	(ABC) transporter
APASM_5631	COG3903	Transcriptional regulator
APASM_5631	COG3629	intracellular signal transduction
APASM_5638	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APASM_5640	COG1946	Acyl-CoA thioesterase
APASM_5648	COG0070	glutamate synthase
APASM_5648	COG0069	glutamate synthase activity
APASM_5648	COG0067	glutamate synthase
APASM_5650	COG1301	dicarboxylic acid transport
APASM_5652	COG2205	protein histidine kinase activity
APASM_5654	COG0745	RESPONSE REGULATOR receiver
APASM_5655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APASM_5656	COG0159	tryptophan synthase activity
APASM_5657	COG0133	tryptophan synthase activity
APASM_5658	COG0134	indole-3-glycerol-phosphate synthase activity
APASM_5661	COG0107	imidazoleglycerol-phosphate synthase activity
APASM_5662	COG3654	unkown
APASM_5665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APASM_5666	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APASM_5668	COG3958	Transketolase
APASM_5669	COG3959	Transketolase, thiamine diphosphate binding domain
APASM_5671	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
APASM_5673	COG0131	Imidazoleglycerol-phosphate dehydratase
APASM_5674	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APASM_5675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APASM_5678	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APASM_5683	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APASM_5690	COG4336	lyase activity
APASM_5694	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APASM_5697	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APASM_5701	COG2814	Major facilitator Superfamily
APASM_5703	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APASM_5705	COG3263	regulation of cellular component size
APASM_5708	COG1872	DUF167
APASM_5709	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APASM_5713	COG1799	cell septum assembly
APASM_5717	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APASM_5718	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APASM_5719	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APASM_5725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APASM_5726	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APASM_5729	COG0768	penicillin binding
APASM_5732	COG0275	rRNA processing
APASM_5733	COG2001	Belongs to the MraZ family
APASM_5734	COG0714	Associated with various cellular activities
APASM_5739	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_5742	COG0174	glutamine synthetase
APASM_5745	COG1192	Involved in chromosome partitioning
APASM_5746	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APASM_5747	COG0167	dihydroorotate dehydrogenase activity
APASM_5749	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_5750	COG2233	PERMEase
APASM_5753	COG1396	sequence-specific DNA binding
APASM_5754	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APASM_5755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APASM_5760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APASM_5761	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APASM_5768	COG1309	transcriptional regulator
APASM_5770	COG0667	Aldo Keto reductase
APASM_5771	COG3214	Protein conserved in bacteria
APASM_5775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APASM_5776	COG0612	Peptidase, M16
APASM_5777	COG1185	polyribonucleotide nucleotidyltransferase activity
APASM_5778	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APASM_5783	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APASM_5786	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APASM_5787	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APASM_5792	COG0779	Required for maturation of 30S ribosomal subunits
APASM_5797	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_5802	COG0442	prolyl-tRNA aminoacylation
APASM_5804	COG3022	response to hydroperoxide
APASM_5805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APASM_5809	COG0513	Belongs to the DEAD box helicase family
APASM_5810	COG1648	precorrin-2 dehydrogenase activity
APASM_5810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APASM_5821	COG0156	8-amino-7-oxononanoate synthase activity
APASM_5824	COG1280	lysine exporter protein (LysE YggA)
APASM_5827	COG0501	Belongs to the peptidase M48B family
APASM_5829	COG0110	maltose O-acetyltransferase activity
APASM_5830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APASM_5832	COG1752	Esterase of the alpha-beta hydrolase superfamily
APASM_5833	COG0726	polysaccharide deacetylase
APASM_5834	COG1881	PFAM PEBP family protein
APASM_5836	COG2807	transmembrane transport
APASM_5839	COG1492	cobalamin metabolic process
APASM_5844	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APASM_5845	COG0750	zinc metalloprotease
APASM_5847	COG2197	response regulator
APASM_5848	COG4585	Histidine kinase
APASM_5849	COG1177	transmembrane transport
APASM_5850	COG1176	ABC-type spermidine putrescine transport system, permease component I
APASM_5852	COG3842	ATPase activity
APASM_5854	COG2815	serine threonine protein kinase
APASM_5854	COG0515	serine threonine protein kinase
APASM_5856	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APASM_5858	COG0667	Aldo Keto reductase
APASM_5862	COG0233	cytoplasmic translational termination
APASM_5863	COG0528	UMP kinase activity
APASM_5864	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APASM_5865	COG0052	Belongs to the universal ribosomal protein uS2 family
APASM_5866	COG1191	sigma factor activity
APASM_5869	COG0606	chelatase, subunit chli
APASM_5870	COG0792	nuclease activity
APASM_5872	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APASM_5873	COG0681	Belongs to the peptidase S26 family
APASM_5874	COG0681	Belongs to the peptidase S26 family
APASM_5875	COG0335	large ribosomal subunit rRNA binding
APASM_5876	COG0336	Belongs to the RNA methyltransferase TrmD family
APASM_5879	COG0228	four-way junction DNA binding
APASM_5880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APASM_5885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APASM_5889	COG4266	Belongs to the allantoicase family
APASM_5890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APASM_5896	COG1414	Transcriptional regulator
APASM_5899	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APASM_5901	COG0454	-acetyltransferase
APASM_5901	COG0456	acetyltransferase
APASM_5908	COG1254	Belongs to the acylphosphatase family
APASM_5909	COG2340	Cysteine-rich secretory protein family
APASM_5912	COG1252	NADH dehydrogenase
APASM_5915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APASM_5917	COG0571	ribonuclease III activity
APASM_5918	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APASM_5921	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APASM_5922	COG0742	ribosomal rna small subunit methyltransferase
APASM_5926	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
APASM_5929	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APASM_5930	COG1461	Dihydroxyacetone kinase
APASM_5931	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APASM_5935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APASM_5936	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APASM_5941	COG1181	Belongs to the D-alanine--D-alanine ligase family
APASM_5944	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_5952	COG0626	cystathionine gamma-synthase activity
APASM_5953	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APASM_5961	COG0066	3-isopropylmalate dehydratase activity
APASM_5962	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APASM_5965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APASM_5967	COG0179	Fumarylacetoacetate (FAA) hydrolase
APASM_5969	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APASM_5970	COG0473	3-isopropylmalate dehydrogenase activity
APASM_5971	COG1404	Belongs to the peptidase S8 family
APASM_5975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APASM_5976	COG0440	acetolactate synthase activity
APASM_5981	COG0129	dihydroxy-acid dehydratase activity
APASM_5982	COG2259	Doxx family
APASM_5991	COG0154	amidase activity
APASM_5992	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APASM_5995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APASM_5998	COG2855	membrane
APASM_6002	COG0482	sulfurtransferase activity
APASM_6007	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APASM_6009	COG1307	EDD domain protein, DegV family
APASM_6014	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APASM_6019	COG0110	maltose O-acetyltransferase activity
APASM_6022	COG2226	methyltransferase
APASM_6023	COG1024	Enoyl-CoA hydratase
APASM_6024	COG1119	ATPase activity
APASM_6029	COG0058	SHG alpha-glucan phosphorylase activity
APASM_6031	COG0366	Alpha amylase catalytic
APASM_6032	COG0366	Alpha amylase catalytic
APASM_6034	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APASM_6035	COG2321	neutral zinc metallopeptidase
APASM_6041	COG1846	Transcriptional regulator
APASM_6043	COG2409	Drug exporters of the RND superfamily
APASM_6044	COG1131	(ABC) transporter
APASM_6048	COG1609	Transcriptional regulator
APASM_6052	COG0596	Alpha beta hydrolase
APASM_6060	COG0183	Belongs to the thiolase family
APASM_6070	COG2376	Dihydroxyacetone kinase
APASM_6080	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
APASM_6083	COG1024	Enoyl-CoA hydratase
APASM_6090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APASM_6091	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APASM_6092	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APASM_6093	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APASM_6094	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APASM_6095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APASM_6096	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APASM_6097	COG0356	it plays a direct role in the translocation of protons across the membrane
APASM_6099	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APASM_6101	COG2890	protein-(glutamine-N5) methyltransferase activity
APASM_6105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APASM_6106	COG0254	rRNA binding
APASM_6108	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APASM_6109	COG0083	homoserine kinase activity
APASM_6110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APASM_6111	COG0460	homoserine dehydrogenase
APASM_6112	COG0019	diaminopimelate decarboxylase activity
APASM_6113	COG0018	arginyl-trna synthetase
APASM_6114	COG3537	Alpha-1,2-mannosidase
APASM_6120	COG1056	cytidyltransferase-related domain
APASM_6120	COG1051	belongs to the nudix hydrolase family
APASM_6125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APASM_6127	COG3629	intracellular signal transduction
APASM_6127	COG3903	Transcriptional regulator
APASM_6128	COG0596	Alpha beta hydrolase
APASM_6136	COG1162	GTPase activity
APASM_6139	COG0667	Aldo Keto reductase
APASM_6140	COG1609	Transcriptional regulator
APASM_6149	COG0601	transmembrane transport
APASM_6150	COG4166	transmembrane transport
APASM_6156	COG2890	protein-(glutamine-N5) methyltransferase activity
APASM_6158	COG4941	Belongs to the sigma-70 factor family
APASM_6159	COG3795	YCII-related domain
APASM_6165	COG0640	Transcriptional regulator
APASM_6167	COG1940	carbohydrate kinase activity
APASM_6170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APASM_6171	COG0745	RESPONSE REGULATOR receiver
APASM_6172	COG2205	protein histidine kinase activity
APASM_6176	COG1404	Belongs to the peptidase S8 family
APASM_6180	COG0583	DNA-binding transcription factor activity
APASM_6186	COG3903	Transcriptional regulator
APASM_6186	COG3629	intracellular signal transduction
APASM_6189	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APASM_6190	COG1960	acyl-CoA dehydrogenase activity
APASM_6191	COG1024	Enoyl-CoA hydratase
APASM_6193	COG1960	acyl-CoA dehydrogenase activity
APASM_6195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APASM_6203	COG3469	chitinase activity
APASM_6204	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APASM_6206	COG0673	inositol 2-dehydrogenase activity
APASM_6210	COG0386	Belongs to the glutathione peroxidase family
APASM_6211	COG1760	l-serine dehydratase
APASM_6212	COG0509	glycine decarboxylation via glycine cleavage system
APASM_6213	COG0686	Belongs to the AlaDH PNT family
APASM_6217	COG1132	(ABC) transporter
APASM_6218	COG0567	Dehydrogenase, E1 component
APASM_6218	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_6221	COG0667	Aldo Keto reductase
APASM_6224	COG3903	Transcriptional regulator
APASM_6224	COG3629	intracellular signal transduction
APASM_6227	COG1228	amidohydrolase
APASM_6230	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APASM_6231	COG2986	histidine ammonia-lyase
APASM_6235	COG1174	glycine betaine transport
APASM_6243	COG5001	Diguanylate cyclase
APASM_6246	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
APASM_6251	COG0406	alpha-ribazole phosphatase activity
APASM_6255	COG1597	lipid kinase activity
APASM_6258	COG5662	AntiSigma factor
APASM_6259	COG1595	DNA-templated transcription, initiation
APASM_6260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APASM_6262	COG2135	peptidase activity
APASM_6263	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APASM_6264	COG1162	GTPase activity
APASM_6269	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APASM_6270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APASM_6272	COG0653	protein targeting
APASM_6273	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APASM_6274	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APASM_6275	COG5401	PFAM Sporulation and spore germination
APASM_6276	COG5002	protein histidine kinase activity
APASM_6277	COG0745	RESPONSE REGULATOR receiver
APASM_6280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APASM_6281	COG0531	amino acid
APASM_6283	COG1482	cell wall glycoprotein biosynthetic process
APASM_6292	COG1994	Peptidase M50
APASM_6294	COG0778	Nitroreductase
APASM_6294	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
APASM_6297	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APASM_6301	COG0438	transferase activity, transferring glycosyl groups
APASM_6305	COG0297	glycogen (starch) synthase activity
APASM_6308	COG1316	TRANSCRIPTIONal
APASM_6309	COG1316	TRANSCRIPTIONal
APASM_6311	COG2259	Doxx family
APASM_6316	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APASM_6321	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APASM_6322	COG2186	Transcriptional regulator
APASM_6330	COG0483	inositol monophosphate 1-phosphatase activity
APASM_6331	COG0745	RESPONSE REGULATOR receiver
APASM_6332	COG2205	protein histidine kinase activity
APASM_6336	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APASM_6339	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APASM_6342	COG0424	maF-like protein
APASM_6343	COG1301	dicarboxylic acid transport
APASM_6345	COG4770	biotin carboxylase activity
APASM_6353	COG2197	response regulator
APASM_6354	COG4585	Histidine kinase
APASM_6357	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APASM_6358	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APASM_6359	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APASM_6362	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APASM_6362	COG1473	amidohydrolase
APASM_6369	COG0515	serine threonine protein kinase
APASM_6371	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APASM_6375	COG3654	unkown
APASM_6379	COG5635	Nacht domain
APASM_6379	COG2319	Wd-40 repeat
APASM_6385	COG3903	Transcriptional regulator
APASM_6385	COG3629	intracellular signal transduction
APASM_6392	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APASM_6412	COG2009	succinate dehydrogenase
APASM_6415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APASM_6416	COG1686	Belongs to the peptidase S11 family
APASM_6419	COG1295	ribonuclease BN
APASM_6420	COG0180	Tryptophanyl-tRNA synthetase
APASM_6422	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APASM_6425	COG0708	Exodeoxyribonuclease III
APASM_6431	COG0484	heat shock protein binding
APASM_6436	COG4555	ABC transporter
APASM_6441	COG0039	L-malate dehydrogenase activity
APASM_6446	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APASM_6450	COG0138	bifunctional purine biosynthesis protein purh
APASM_6455	COG0045	succinate-CoA ligase (ADP-forming) activity
APASM_6457	COG0739	heme binding
APASM_6465	COG0515	serine threonine protein kinase
APASM_6465	COG2815	serine threonine protein kinase
APASM_6466	COG0515	serine threonine protein kinase
APASM_6467	COG0583	DNA-binding transcription factor activity
APASM_6468	COG0697	spore germination
APASM_6474	COG0519	Catalyzes the synthesis of GMP from XMP
APASM_6474	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APASM_6476	COG1012	belongs to the aldehyde dehydrogenase family
APASM_6479	COG0516	GMP reductase activity
APASM_6484	COG2197	response regulator
APASM_6488	COG0459	protein refolding
APASM_6489	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APASM_6491	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APASM_6492	COG0456	acetyltransferase
APASM_6495	COG3118	belongs to the thioredoxin family
APASM_6496	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_6497	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APASM_6501	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APASM_6503	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APASM_6509	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APASM_6510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APASM_6511	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APASM_6514	COG0443	Heat shock 70 kDa protein
APASM_6516	COG1674	ftsk spoiiie
APASM_6518	COG1404	Belongs to the peptidase S8 family
APASM_6525	COG1404	Belongs to the peptidase S8 family
APASM_6526	COG0101	tRNA pseudouridine synthase activity
APASM_6527	COG0203	ribosomal protein L17
APASM_6528	COG0202	RNA polymerase activity
APASM_6529	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APASM_6530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APASM_6531	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APASM_6532	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APASM_6538	COG0563	adenylate kinase activity
APASM_6542	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APASM_6543	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APASM_6545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APASM_6546	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APASM_6547	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APASM_6548	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APASM_6549	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APASM_6550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APASM_6551	COG0255	Belongs to the universal ribosomal protein uL29 family
APASM_6552	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APASM_6553	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APASM_6554	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APASM_6555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APASM_6556	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APASM_6557	COG0089	rRNA binding
APASM_6558	COG0088	Forms part of the polypeptide exit tunnel
APASM_6559	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APASM_6560	COG0051	transcription antitermination factor activity, RNA binding
APASM_6561	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APASM_6562	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APASM_6563	COG0049	tRNA binding
APASM_6564	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APASM_6572	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APASM_6573	COG0085	RNA polymerase activity
APASM_6579	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APASM_6583	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APASM_6585	COG0081	regulation of translation
APASM_6586	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APASM_6588	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APASM_6589	COG0436	Aminotransferase
APASM_6592	COG2030	dehydratase
APASM_6593	COG2030	dehydratase
APASM_6594	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APASM_6599	COG1666	GTP binding
APASM_6600	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APASM_6602	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_6603	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_6603	COG0649	NAD binding
APASM_6604	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_6607	COG1834	amidinotransferase
APASM_6608	COG1522	sequence-specific DNA binding
APASM_6610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APASM_6610	COG0674	pyruvate-flavodoxin oxidoreductase activity
APASM_6611	COG1013	pyruvate-flavodoxin oxidoreductase activity
APASM_6615	COG1007	ATP synthesis coupled electron transport
APASM_6618	COG0713	ATP synthesis coupled electron transport
APASM_6620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_6621	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APASM_6622	COG1034	ATP synthesis coupled electron transport
APASM_6623	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APASM_6625	COG0649	NAD binding
APASM_6626	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_6627	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APASM_6630	COG2226	methyltransferase
APASM_6631	COG0483	inositol monophosphate 1-phosphatase activity
APASM_6634	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APASM_6635	COG2151	metal-sulfur cluster biosynthetic enzyme
APASM_6636	COG3396	Phenylacetate-CoA oxygenase
APASM_6637	COG3460	Phenylacetate-CoA oxygenase
APASM_6638	COG3396	Phenylacetate-CoA oxygenase
APASM_6648	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APASM_6658	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APASM_6659	COG1333	cytochrome c biogenesis protein
APASM_6660	COG0785	Cytochrome C biogenesis protein
APASM_6664	COG0406	alpha-ribazole phosphatase activity
APASM_6665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APASM_6673	COG0113	porphobilinogen synthase activity
APASM_6675	COG0181	hydroxymethylbilane synthase activity
APASM_6676	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APASM_6677	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
APASM_6681	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_6684	COG0560	Phosphoserine phosphatase
APASM_6689	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APASM_6695	COG0667	Aldo Keto reductase
APASM_6697	COG0588	phosphoglycerate mutase activity
APASM_6698	COG0318	PFAM AMP-dependent synthetase and ligase
APASM_6701	COG0438	transferase activity, transferring glycosyl groups
APASM_6705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APASM_6711	COG3226	Transcriptional regulator
APASM_6713	COG0789	Transcriptional regulator
APASM_6714	COG0693	protein deglycase activity
APASM_6719	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APASM_6720	COG2733	membrane
APASM_6726	COG1136	(ABC) transporter
APASM_6733	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_6734	COG2364	Membrane
APASM_6744	COG1278	Cold shock
APASM_6748	COG2255	four-way junction helicase activity
APASM_6758	COG0745	RESPONSE REGULATOR receiver
APASM_6758	COG3706	GGDEF domain
APASM_6763	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APASM_6772	COG4044	May play a role in the intracellular transport of hydrophobic ligands
APASM_6773	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APASM_6784	COG3718	enzyme involved in inositol metabolism
APASM_6786	COG1129	ABC transporter
APASM_6787	COG1172	Belongs to the binding-protein-dependent transport system permease family
APASM_6789	COG1082	Xylose isomerase domain protein TIM barrel
APASM_6792	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APASM_6795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APASM_6808	COG1063	alcohol dehydrogenase
APASM_6809	COG5001	Diguanylate cyclase
APASM_6809	COG3300	MHYT domain
APASM_6814	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APASM_6815	COG0047	phosphoribosylformylglycinamidine synthase activity
APASM_6816	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APASM_6821	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APASM_6823	COG0765	amino acid transport
APASM_6826	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APASM_6828	COG1595	DNA-templated transcription, initiation
APASM_6831	COG1595	DNA-templated transcription, initiation
APASM_6832	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APASM_6843	COG0584	glycerophosphoryl diester phosphodiesterase
APASM_6844	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APASM_6849	COG4129	membrane
APASM_6854	COG0667	Aldo Keto reductase
APASM_6855	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_6857	COG1595	DNA-templated transcription, initiation
APASM_6862	COG0277	FAD linked oxidase domain protein
APASM_6863	COG0586	Pfam SNARE associated Golgi protein
APASM_6864	COG1072	(Pantothenic acid kinase))
APASM_6870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APASM_6875	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_6877	COG0542	response to heat
APASM_6879	COG2871	sodium ion transport
APASM_6880	COG0789	Transcriptional regulator
APASM_6881	COG0484	heat shock protein binding
APASM_6882	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APASM_6883	COG0443	Heat shock 70 kDa protein
APASM_6889	COG0247	lactate metabolic process
APASM_6889	COG2181	nitrate reductase activity
APASM_6890	COG1950	PFAM Membrane protein of
APASM_6895	COG0717	Belongs to the dCTP deaminase family
APASM_6898	COG2197	response regulator
APASM_6899	COG1960	acyl-CoA dehydrogenase activity
APASM_6902	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APASM_6909	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_6912	COG1960	acyl-CoA dehydrogenase activity
APASM_6914	COG1309	transcriptional regulator
APASM_6915	COG0789	Transcriptional regulator
APASM_6916	COG0508	dehydrogenase complex catalyzes the overall conversion of
APASM_6917	COG0022	dehydrogenase e1 component
APASM_6919	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APASM_6921	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APASM_6922	COG0765	amino acid transport
APASM_6929	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
APASM_6935	COG1940	carbohydrate kinase activity
APASM_6943	COG4585	Histidine kinase
APASM_6944	COG2197	response regulator
APASM_6945	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_6947	COG0561	phosphatase activity
APASM_6949	COG4585	Histidine kinase
APASM_6950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APASM_6955	COG1131	(ABC) transporter
APASM_6958	COG0402	S-adenosylhomocysteine deaminase activity
APASM_6959	COG4221	oxidoreductase activity
APASM_6963	COG2814	Major facilitator Superfamily
APASM_6964	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APASM_6965	COG1028	Short-chain dehydrogenase reductase Sdr
APASM_6969	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APASM_6974	COG0360	Binds together with S18 to 16S ribosomal RNA
APASM_6975	COG0629	single-stranded DNA binding
APASM_6976	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APASM_6977	COG0359	binds to the 23S rRNA
APASM_6978	COG0305	Participates in initiation and elongation during chromosome replication
APASM_6985	COG2203	Gaf domain
APASM_6985	COG4251	negative regulation of phosphorylation
APASM_6985	COG5001	Diguanylate cyclase
APASM_6985	COG3706	GGDEF domain
APASM_6991	COG3706	GGDEF domain
APASM_6991	COG0745	RESPONSE REGULATOR receiver
APASM_7000	COG0702	epimerase
APASM_7001	COG1063	alcohol dehydrogenase
APASM_7003	COG0583	DNA-binding transcription factor activity
APASM_7007	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APASM_7008	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APASM_7013	COG0495	leucyl-tRNA aminoacylation
APASM_7017	COG2197	response regulator
APASM_7018	COG0617	tRNA 3'-terminal CCA addition
APASM_7022	COG0515	serine threonine protein kinase
APASM_7025	COG3118	belongs to the thioredoxin family
APASM_7025	COG0492	ferredoxin-NADP+ reductase activity
APASM_7026	COG3409	Peptidoglycan-binding domain 1 protein
APASM_7026	COG0860	N-Acetylmuramoyl-L-alanine amidase
APASM_7028	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APASM_7029	COG1181	Belongs to the D-alanine--D-alanine ligase family
APASM_7031	COG1192	Involved in chromosome partitioning
APASM_7032	COG0357	Ribosomal RNA small subunit methyltransferase G
APASM_7035	COG0706	membrane insertase activity
APASM_7036	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APASM_7037	COG0594	ribonuclease P activity
APASM_7038	COG0230	Belongs to the bacterial ribosomal protein bL34 family