locus-tag	class	description
FB03_00020	COG1609	Transcriptional regulator
FB03_00035	COG2160	L-arabinose isomerase activity
FB03_00050	COG1129	ABC transporter
FB03_00065	COG2376	Dihydroxyacetone kinase
FB03_00075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FB03_00090	COG1304	FMN binding
FB03_00115	COG0765	amino acid transport
FB03_00120	COG0765	amino acid transport
FB03_00125	COG1126	abc transporter atp-binding protein
FB03_00135	COG3425	synthase
FB03_00150	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FB03_00165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FB03_00185	COG1946	Acyl-CoA thioesterase
FB03_00190	COG1002	Type II restriction enzyme, methylase subunits
FB03_00205	COG0659	secondary active sulfate transmembrane transporter activity
FB03_00220	COG2814	Major facilitator Superfamily
FB03_00220	COG0477	Major facilitator Superfamily
FB03_00240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FB03_00245	COG2197	response regulator
FB03_00260	COG1131	(ABC) transporter
FB03_00265	COG3590	peptidase
FB03_00275	COG1045	serine acetyltransferase
FB03_00290	COG1739	Uncharacterized protein family UPF0029
FB03_00325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FB03_00330	COG2011	ABC-type metal ion transport system permease component
FB03_00345	COG0544	peptidyl-prolyl cis-trans isomerase activity
FB03_00360	COG0740	serine-type endopeptidase activity
FB03_00365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FB03_00380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FB03_00390	COG1215	transferase activity, transferring glycosyl groups
FB03_00400	COG0745	RESPONSE REGULATOR receiver
FB03_00410	COG0525	valine-tRNA ligase activity
FB03_00420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FB03_00430	COG0444	Belongs to the ABC transporter superfamily
FB03_00445	COG0747	negative chemotaxis
FB03_00465	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FB03_00485	COG1114	Component of the transport system for branched-chain amino acids
FB03_00490	COG1957	nucleoside hydrolase
FB03_00505	COG0569	domain protein
FB03_00505	COG2985	domain, Protein
FB03_00530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FB03_00535	COG0228	four-way junction DNA binding
FB03_00540	COG1837	Belongs to the UPF0109 family
FB03_00555	COG0335	large ribosomal subunit rRNA binding
FB03_00575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FB03_00585	COG0792	nuclease activity
FB03_00590	COG0606	chelatase, subunit chli
FB03_00600	COG4974	Belongs to the 'phage' integrase family
FB03_00625	COG4555	ABC transporter
FB03_00630	COG0052	Belongs to the universal ribosomal protein uS2 family
FB03_00635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FB03_00640	COG2116	formate transmembrane transporter activity
FB03_00645	COG2855	membrane
FB03_00655	COG0233	cytoplasmic translational termination
FB03_00660	COG0575	Belongs to the CDS family
FB03_00670	COG0456	acetyltransferase
FB03_00670	COG0454	-acetyltransferase
FB03_00675	COG0442	prolyl-tRNA aminoacylation
FB03_00690	COG0779	Required for maturation of 30S ribosomal subunits
FB03_00700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FB03_00700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FB03_00705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FB03_00730	COG0196	riboflavin kinase activity
FB03_00735	COG1950	PFAM Membrane protein of
FB03_00750	COG0612	Peptidase, M16
FB03_00760	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FB03_00765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FB03_00770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FB03_00775	COG1674	ftsk spoiiie
FB03_00785	COG1058	Belongs to the CinA family
FB03_00785	COG1546	Belongs to the CinA family
FB03_00790	COG1396	sequence-specific DNA binding
FB03_00800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FB03_00815	COG2813	Specifically methylates the guanine in position
FB03_00830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FB03_00875	COG2001	Belongs to the MraZ family
FB03_00880	COG0275	rRNA processing
FB03_00890	COG0768	penicillin binding
FB03_00895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FB03_00900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FB03_00905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FB03_00910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FB03_00915	COG0772	Belongs to the SEDS family
FB03_00920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FB03_00925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FB03_00945	COG1799	cell septum assembly
FB03_00980	COG0803	Belongs to the bacterial solute-binding protein 9 family
FB03_00990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FB03_01005	COG0423	glycine-tRNA ligase activity
FB03_01010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FB03_01015	COG1181	Belongs to the D-alanine--D-alanine ligase family
FB03_01060	COG0358	DNA primase activity
FB03_01065	COG1414	Transcriptional regulator
FB03_01110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FB03_01130	COG1172	Belongs to the binding-protein-dependent transport system permease family
FB03_01140	COG1879	ABC-type sugar transport system periplasmic component
FB03_01145	COG1609	Transcriptional regulator
FB03_01190	COG0009	L-threonylcarbamoyladenylate synthase
FB03_01215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FB03_01235	COG3104	oligopeptide transport
FB03_01245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FB03_01270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FB03_01280	COG0174	glutamine synthetase
FB03_01285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FB03_01310	COG0508	dehydrogenase complex catalyzes the overall conversion of
FB03_01315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FB03_01335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FB03_01340	COG0545	Peptidyl-prolyl cis-trans isomerase
FB03_01345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FB03_01365	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FB03_01370	COG0515	serine threonine protein kinase
FB03_01370	COG2815	serine threonine protein kinase
FB03_01400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FB03_01415	COG0187	DNA topoisomerase II activity
FB03_01425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FB03_01465	COG0569	domain protein
FB03_01475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FB03_01480	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FB03_01535	COG0783	Belongs to the Dps family
FB03_01540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FB03_01550	COG1560	Kdo2-lipid A biosynthetic process
FB03_01575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FB03_01580	COG0632	four-way junction helicase activity
FB03_01585	COG2255	four-way junction helicase activity
FB03_01595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FB03_01600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FB03_01605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FB03_01610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FB03_01620	COG1196	nuclear chromosome segregation
FB03_01625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FB03_01630	COG0124	histidyl-tRNA synthetase
FB03_01640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FB03_01650	COG0137	argininosuccinate synthase activity
FB03_01655	COG0477	Major facilitator Superfamily
FB03_01665	COG0165	Argininosuccinate lyase
FB03_01670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FB03_01715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FB03_01755	COG0719	Fe-S assembly protein
FB03_01770	COG0396	ATPase activity
FB03_01785	COG2151	metal-sulfur cluster biosynthetic enzyme
FB03_01800	COG0488	(ABC) transporter
FB03_01810	COG0297	glycogen (starch) synthase activity
FB03_01815	COG1119	ATPase activity
FB03_01840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FB03_01855	COG0587	DNA-directed DNA polymerase activity
FB03_01870	COG0339	signal peptide processing
FB03_01890	COG1968	undecaprenyl-diphosphatase activity
FB03_01895	COG0215	cysteine-tRNA ligase activity
FB03_01915	COG4122	O-methyltransferase activity
FB03_01925	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FB03_01940	COG0134	indole-3-glycerol-phosphate synthase activity
FB03_01950	COG0469	pyruvate kinase activity
FB03_01975	COG0539	negative regulation of cytoplasmic translation
FB03_01980	COG0237	dephospho-CoA kinase activity
FB03_01985	COG2610	gluconate transmembrane transporter activity
FB03_01990	COG0676	glucose-6-phosphate 1-epimerase activity
FB03_01995	COG0556	nucleotide-excision repair
FB03_02000	COG0861	Integral membrane protein TerC family
FB03_02015	COG0322	excinuclease ABC activity
FB03_02020	COG1660	Displays ATPase and GTPase activities
FB03_02030	COG1481	regulation of sporulation
FB03_02035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FB03_02040	COG0126	phosphoglycerate kinase activity
FB03_02045	COG0149	triose-phosphate isomerase activity
FB03_02050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FB03_02085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FB03_02105	COG1160	GTP binding
FB03_02115	COG0246	Mannitol dehydrogenase
FB03_02120	COG1312	Catalyzes the dehydration of D-mannonate
FB03_02125	COG0800	Aldolase
FB03_02130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FB03_02145	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FB03_02165	COG1120	ATPase activity
FB03_02175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FB03_02180	COG1132	(ABC) transporter
FB03_02185	COG4988	ABC transporter
FB03_02195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FB03_02210	COG0738	Major facilitator superfamily
FB03_02220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FB03_02250	COG1716	ATPase activity
FB03_02270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FB03_02290	COG1216	Glycosyl transferase, family 2
FB03_02335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FB03_02340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FB03_02345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FB03_02355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FB03_02365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FB03_02380	COG0194	GDP metabolic process
FB03_02385	COG0194	GDP metabolic process
FB03_02395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FB03_02400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FB03_02405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FB03_02410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FB03_02415	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FB03_02425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FB03_02435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FB03_02445	COG2409	Drug exporters of the RND superfamily
FB03_02455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FB03_02460	COG0477	Major facilitator Superfamily
FB03_02480	COG0300	oxidoreductase activity
FB03_02490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FB03_02500	COG1904	glucuronate isomerase
FB03_02510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FB03_02515	COG0584	glycerophosphoryl diester phosphodiesterase
FB03_02525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FB03_02530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FB03_02545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FB03_02560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FB03_02565	COG1381	Involved in DNA repair and RecF pathway recombination
FB03_02580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FB03_02590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FB03_02605	COG0484	heat shock protein binding
FB03_02610	COG1420	regulation of RNA biosynthetic process
FB03_02640	COG0481	GTPase activity
FB03_02645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FB03_02655	COG0268	Binds directly to 16S ribosomal RNA
FB03_02660	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FB03_02665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FB03_02685	COG0433	COG0433 Predicted ATPase
FB03_02695	COG0495	leucyl-tRNA aminoacylation
FB03_02720	COG3769	mannosylglycerate metabolic process
FB03_02725	COG1309	transcriptional regulator
FB03_02730	COG0842	Transport permease protein
FB03_02735	COG1131	(ABC) transporter
FB03_02760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FB03_02765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FB03_02770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FB03_02790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FB03_02795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FB03_02800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FB03_02805	COG1530	ribonuclease E activity
FB03_02810	COG1271	oxidase subunit
FB03_02815	COG1294	oxidase, subunit
FB03_02820	COG4988	ABC transporter
FB03_02825	COG1132	(ABC) transporter
FB03_02840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FB03_02845	COG0571	ribonuclease III activity
FB03_02860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FB03_02865	COG0742	ribosomal rna small subunit methyltransferase
FB03_02875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FB03_02880	COG1028	Short-chain dehydrogenase reductase Sdr
FB03_02890	COG1064	alcohol dehydrogenase
FB03_02895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FB03_02900	COG1181	Belongs to the D-alanine--D-alanine ligase family
FB03_02910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FB03_02915	COG0066	3-isopropylmalate dehydratase activity
FB03_02920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FB03_02975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FB03_02985	COG0179	Fumarylacetoacetate (FAA) hydrolase
FB03_02995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FB03_03000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FB03_03020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FB03_03025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FB03_03035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FB03_03045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FB03_03160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FB03_03180	COG2884	Cell division ATP-binding protein ftsE
FB03_03245	COG0513	Belongs to the DEAD box helicase family
FB03_03250	COG2095	MarC family integral membrane protein
FB03_03260	COG0613	PHP domain protein
FB03_03265	COG0006	proline dipeptidase activity
FB03_03280	COG2151	metal-sulfur cluster biosynthetic enzyme
FB03_03280	COG0489	protein tyrosine kinase activity
FB03_03300	COG1611	Belongs to the LOG family
FB03_03305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FB03_03305	COG0662	Cupin 2, conserved barrel domain protein
FB03_03320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FB03_03330	COG0833	amino acid
FB03_03335	COG0736	holo-[acyl-carrier-protein] synthase activity
FB03_03385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FB03_03390	COG4770	biotin carboxylase activity
FB03_03415	COG0166	Belongs to the GPI family
FB03_03465	COG1253	flavin adenine dinucleotide binding
FB03_03485	COG0159	tryptophan synthase activity
FB03_03490	COG0133	tryptophan synthase activity
FB03_03505	COG0803	Belongs to the bacterial solute-binding protein 9 family
FB03_03510	COG1121	(ABC) transporter
FB03_03530	COG1012	belongs to the aldehyde dehydrogenase family
FB03_03545	COG1882	Formate acetyltransferase
FB03_03550	COG1882	Formate acetyltransferase
FB03_03555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FB03_03555	COG0519	Catalyzes the synthesis of GMP from XMP
FB03_03560	COG0857	belongs to the CobB CobQ family
FB03_03560	COG0280	phosphate acetyltransferase
FB03_03565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FB03_03590	COG0673	inositol 2-dehydrogenase activity
FB03_03610	COG0686	Belongs to the AlaDH PNT family
FB03_03625	COG0516	GMP reductase activity
FB03_03630	COG2348	transferase activity, transferring amino-acyl groups
FB03_03645	COG0737	Belongs to the 5'-nucleotidase family
FB03_03645	COG1525	nuclease
FB03_03645	COG4085	toxin activity
FB03_03650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FB03_03675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FB03_03705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FB03_03715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FB03_03720	COG4948	Mandelate Racemase Muconate Lactonizing
FB03_03740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FB03_03745	COG0802	atpase or kinase
FB03_03750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FB03_03760	COG1072	(Pantothenic acid kinase))
FB03_03770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FB03_03775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FB03_03785	COG0101	tRNA pseudouridine synthase activity
FB03_03795	COG0203	ribosomal protein L17
FB03_03800	COG0202	RNA polymerase activity
FB03_03805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FB03_03810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FB03_03815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FB03_03820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FB03_03830	COG0563	adenylate kinase activity
FB03_03845	COG1841	ribosomal large subunit assembly
FB03_03850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FB03_03860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FB03_03865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FB03_03870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FB03_03875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FB03_03880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FB03_03885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FB03_03890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FB03_03895	COG0255	Belongs to the universal ribosomal protein uL29 family
FB03_03900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FB03_03905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FB03_03910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FB03_03915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FB03_03920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FB03_03925	COG0089	rRNA binding
FB03_03935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FB03_03940	COG0051	transcription antitermination factor activity, RNA binding
FB03_03945	COG1012	belongs to the aldehyde dehydrogenase family
FB03_03950	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FB03_03960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FB03_03965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FB03_03970	COG0049	tRNA binding
FB03_03975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FB03_03980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FB03_03985	COG0085	RNA polymerase activity
FB03_03990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FB03_03995	COG0222	ribosome binding
FB03_04000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FB03_04010	COG0081	regulation of translation
FB03_04015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FB03_04020	COG0250	Participates in transcription elongation, termination and antitermination
FB03_04025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FB03_04035	COG0436	Aminotransferase
FB03_04055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FB03_04060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FB03_04080	COG0095	Lipoate-protein ligase
FB03_04090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FB03_04095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FB03_04100	COG5401	PFAM Sporulation and spore germination
FB03_04110	COG0745	RESPONSE REGULATOR receiver
FB03_04140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FB03_04160	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FB03_04230	COG1215	transferase activity, transferring glycosyl groups
FB03_04260	COG1215	transferase activity, transferring glycosyl groups
FB03_04280	COG1088	dTDP-glucose 4,6-dehydratase activity
FB03_04305	COG1316	TRANSCRIPTIONal
FB03_04310	COG1316	TRANSCRIPTIONal
FB03_04320	COG2205	protein histidine kinase activity
FB03_04325	COG0745	RESPONSE REGULATOR receiver
FB03_04395	COG0318	PFAM AMP-dependent synthetase and ligase
FB03_04400	COG1362	aminopeptidase activity
FB03_04410	COG3158	transport of potassium into the cell
FB03_04455	COG0012	GTP binding
FB03_04460	COG1028	Short-chain dehydrogenase reductase Sdr
FB03_04465	COG1322	Protein conserved in bacteria
FB03_04470	COG1570	exodeoxyribonuclease VII activity
FB03_04495	COG2326	polyphosphate kinase activity
FB03_04505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FB03_04510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FB03_04525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FB03_04550	COG0148	phosphopyruvate hydratase activity
FB03_04570	COG0193	aminoacyl-tRNA hydrolase activity
FB03_04575	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FB03_04600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FB03_04625	COG0488	(ABC) transporter
FB03_04650	COG0084	hydrolase, TatD family'
FB03_04655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FB03_04665	COG4566	intracellular signal transduction
FB03_04675	COG0549	Belongs to the carbamate kinase family
FB03_04680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FB03_04695	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
FB03_04705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FB03_04715	COG1113	amino acid transport
FB03_04720	COG1012	belongs to the aldehyde dehydrogenase family
FB03_04730	COG0561	phosphatase activity
FB03_04740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FB03_04755	COG1136	(ABC) transporter
FB03_04805	COG1970	mechanosensitive ion channel activity
FB03_04825	COG0438	transferase activity, transferring glycosyl groups
FB03_04860	COG1321	iron dependent repressor
FB03_04870	COG2252	PERMEase
FB03_04875	COG1482	cell wall glycoprotein biosynthetic process
FB03_04885	COG1278	Cold shock
FB03_04900	COG0745	RESPONSE REGULATOR receiver
FB03_04915	COG0300	oxidoreductase activity
FB03_04925	COG0459	protein refolding
FB03_04940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FB03_04965	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FB03_04990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FB03_04990	COG0515	serine threonine protein kinase
FB03_05015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FB03_05045	COG2233	PERMEase
FB03_05070	COG0215	cysteine-tRNA ligase activity
FB03_05085	COG0745	RESPONSE REGULATOR receiver
FB03_05100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FB03_05105	COG1121	(ABC) transporter
FB03_05120	COG0588	phosphoglycerate mutase activity
FB03_05125	COG1012	belongs to the aldehyde dehydrogenase family
FB03_05125	COG1454	alcohol dehydrogenase
FB03_05150	COG1136	(ABC) transporter
FB03_05160	COG0626	cystathionine gamma-synthase activity
FB03_05165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FB03_05170	COG0765	amino acid transport
FB03_05210	COG1063	alcohol dehydrogenase
FB03_05220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FB03_05225	COG1754	DNA topoisomerase type I activity
FB03_05225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FB03_05290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FB03_05335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FB03_05360	COG2223	nitrite transmembrane transporter activity
FB03_05380	COG2964	Protein conserved in bacteria
FB03_05385	COG3048	D-serine ammonia-lyase activity
FB03_05390	COG2610	gluconate transmembrane transporter activity
FB03_05400	COG1063	alcohol dehydrogenase
FB03_05435	COG1454	alcohol dehydrogenase
FB03_05445	COG2271	Major facilitator Superfamily
FB03_05455	COG1414	Transcriptional regulator
FB03_05460	COG0656	L-ascorbic acid biosynthetic process
FB03_05470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FB03_05470	COG0574	Belongs to the PEP-utilizing enzyme family
FB03_05475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FB03_05510	COG2197	response regulator
FB03_05545	COG0477	Major facilitator Superfamily
FB03_05575	COG0129	dihydroxy-acid dehydratase activity
FB03_05580	COG0561	phosphatase activity
FB03_05600	COG4214	carbohydrate transport
FB03_05610	COG4213	ABC transporter substrate-binding protein
FB03_05615	COG2115	Belongs to the xylose isomerase family
FB03_05625	COG1070	Carbohydrate kinase
FB03_05645	COG0542	response to heat
FB03_05650	COG1490	D-aminoacyl-tRNA deacylase activity
FB03_05675	COG0306	phosphate transporter
FB03_05680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FB03_05685	COG0581	inorganic phosphate transmembrane transporter activity
FB03_05705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FB03_05725	COG2076	Multidrug Resistance protein
FB03_05730	COG2076	Multidrug Resistance protein
FB03_05755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FB03_05795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FB03_05825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FB03_05835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FB03_05840	COG0058	SHG alpha-glucan phosphorylase activity
FB03_05900	COG0191	fructose-bisphosphate aldolase activity
FB03_05955	COG0488	(ABC) transporter
FB03_05975	COG2860	membrane
FB03_06000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FB03_06000	COG2755	lipolytic protein G-D-S-L family
FB03_06025	COG3177	Filamentation induced by cAMP protein fic
FB03_06030	COG1643	Atp-dependent helicase
FB03_06050	COG3842	ATPase activity
FB03_06060	COG0477	Major facilitator Superfamily
FB03_06065	COG1063	alcohol dehydrogenase
FB03_06070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FB03_06075	COG0363	glucosamine-6-phosphate deaminase activity
FB03_06080	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FB03_06090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FB03_06095	COG4608	Belongs to the ABC transporter superfamily
FB03_06100	COG0444	Belongs to the ABC transporter superfamily
FB03_06110	COG0747	negative chemotaxis
FB03_06130	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FB03_06180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FB03_06215	COG1643	Atp-dependent helicase
FB03_06230	COG1136	(ABC) transporter
FB03_06270	COG4868	Belongs to the UPF0371 family
FB03_06285	COG0343	queuine tRNA-ribosyltransferase activity
FB03_06345	COG1002	Type II restriction enzyme, methylase subunits
FB03_06350	COG1061	Type III restriction enzyme res subunit
FB03_06355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FB03_06380	COG2723	6-phospho-beta-galactosidase activity
FB03_06385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FB03_06435	COG0656	L-ascorbic acid biosynthetic process
FB03_06440	COG0351	phosphomethylpyrimidine kinase
FB03_06460	COG0305	Participates in initiation and elongation during chromosome replication
FB03_06475	COG0359	binds to the 23S rRNA
FB03_06480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FB03_06490	COG0360	Binds together with S18 to 16S ribosomal RNA
FB03_06505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FB03_06510	COG0628	permease
FB03_06550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FB03_06555	COG1181	Belongs to the D-alanine--D-alanine ligase family
FB03_06565	COG1192	Involved in chromosome partitioning
FB03_06570	COG0357	Ribosomal RNA small subunit methyltransferase G
FB03_06580	COG0706	membrane insertase activity
FB03_06590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FB03_06595	COG0592	DNA-directed DNA polymerase activity
FB03_06600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FB03_06605	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FB03_06620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FB03_06625	COG3266	domain, Protein
FB03_06665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FB03_06685	COG0235	Class ii aldolase
FB03_06690	COG1070	Carbohydrate kinase
FB03_06700	COG2814	Major facilitator Superfamily
FB03_06705	COG3254	rhamnose metabolic process
FB03_06730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FB03_06760	COG0205	6-phosphofructokinase activity
FB03_06770	COG3764	Sortase (surface protein transpeptidase)
FB03_06780	COG0515	serine threonine protein kinase
FB03_06785	COG0768	penicillin binding
FB03_06805	COG1131	(ABC) transporter
FB03_06805	COG1716	ATPase activity
FB03_06805	COG0842	Transport permease protein
FB03_06815	COG1132	(ABC) transporter
FB03_06835	COG1136	(ABC) transporter
FB03_06865	COG0328	RNA-DNA hybrid ribonuclease activity
FB03_06880	COG1854	S-ribosylhomocysteine lyase activity
FB03_06895	COG2161	toxin-antitoxin pair type II binding
FB03_06930	COG1760	l-serine dehydratase
FB03_06935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FB03_06955	COG1414	Transcriptional regulator
FB03_06965	COG2610	gluconate transmembrane transporter activity
FB03_06970	COG2084	Dehydrogenase
FB03_06975	COG4948	Mandelate Racemase Muconate Lactonizing
FB03_06980	COG1929	Belongs to the glycerate kinase type-1 family
FB03_07000	COG1556	Lactate utilization protein
FB03_07005	COG1139	Iron-sulfur cluster binding protein
FB03_07010	COG0247	lactate metabolic process
FB03_07015	COG1620	l-lactate permease
FB03_07020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FB03_07030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FB03_07050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FB03_07080	COG0561	phosphatase activity
FB03_07085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FB03_07095	COG0077	Prephenate dehydratase
FB03_07110	COG1215	transferase activity, transferring glycosyl groups
FB03_07130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FB03_07135	COG0590	tRNA wobble adenosine to inosine editing
FB03_07155	COG1230	cation diffusion facilitator family transporter
FB03_07190	COG1735	metal-dependent hydrolase with the TIM-barrel fold
FB03_07200	COG3623	hexulose-6-phosphate isomerase
FB03_07210	COG1105	Belongs to the carbohydrate kinase PfkB family
FB03_07240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FB03_07270	COG0435	Glutathione S-transferase
FB03_07275	COG1136	(ABC) transporter
FB03_07275	COG0577	efflux transmembrane transporter activity
FB03_07285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FB03_07310	COG2217	Heavy metal translocating P-type atpase
FB03_07330	COG0586	Pfam SNARE associated Golgi protein
FB03_07335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FB03_07350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FB03_07365	COG0494	nUDIX hydrolase
FB03_07375	COG2094	Belongs to the DNA glycosylase MPG family
FB03_07385	COG0604	alcohol dehydrogenase
FB03_07390	COG1473	amidohydrolase
FB03_07415	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FB03_07430	COG0431	NADPH-dependent FMN reductase
FB03_07435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FB03_07450	COG1309	transcriptional regulator
FB03_07515	COG1511	domain protein
FB03_07515	COG1511	domain protein
FB03_07525	COG0402	S-adenosylhomocysteine deaminase activity
FB03_07530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FB03_07625	COG0717	Belongs to the dCTP deaminase family
FB03_07630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FB03_07630	COG2111	Na H antiporter
FB03_07665	COG4143	(ABC) transporter
FB03_07675	COG3842	ATPase activity
FB03_07685	COG2197	response regulator
FB03_07710	COG1940	carbohydrate kinase activity
FB03_07715	COG0443	Heat shock 70 kDa protein
FB03_07720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FB03_07725	COG0484	heat shock protein binding
FB03_07735	COG1132	(ABC) transporter
FB03_07775	COG3022	response to hydroperoxide
FB03_07795	COG2197	response regulator
FB03_07815	COG3579	cysteine-type endopeptidase activity
FB03_07820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FB03_07825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FB03_07865	COG1674	ftsk spoiiie
FB03_07980	COG2873	o-acetylhomoserine
FB03_07990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FB03_08000	COG0037	tRNA processing
FB03_08010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FB03_08015	COG0302	gtp cyclohydrolase
FB03_08055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FB03_08075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FB03_08080	COG2271	Major facilitator Superfamily
FB03_08095	COG3386	PFAM SMP-30 Gluconolaconase
FB03_08100	COG1620	l-lactate permease
FB03_08120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FB03_08125	COG0569	domain protein
FB03_08145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FB03_08165	COG0406	alpha-ribazole phosphatase activity
FB03_08185	COG2226	methyltransferase
FB03_08195	COG0653	protein targeting
FB03_08250	COG0419	ATPase involved in DNA repair
FB03_08260	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FB03_08265	COG0483	inositol monophosphate 1-phosphatase activity
FB03_08270	COG1162	GTPase activity
FB03_08275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FB03_08285	COG1595	DNA-templated transcription, initiation
FB03_08315	COG1131	(ABC) transporter
FB03_08345	COG1253	flavin adenine dinucleotide binding
FB03_08375	COG0018	arginyl-trna synthetase
FB03_08380	COG0019	diaminopimelate decarboxylase activity
FB03_08385	COG0710	3-dehydroquinate dehydratase activity
FB03_08390	COG0460	homoserine dehydrogenase
FB03_08395	COG0083	homoserine kinase activity
FB03_08415	COG2890	protein-(glutamine-N5) methyltransferase activity
FB03_08435	COG0356	it plays a direct role in the translocation of protons across the membrane
FB03_08440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FB03_08445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FB03_08450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FB03_08455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FB03_08460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FB03_08465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FB03_08480	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FB03_08485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FB03_08550	COG1175	transmembrane transport
FB03_08555	COG3833	ABC-type maltose transport systems, permease component
FB03_08560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FB03_08575	COG0366	Alpha amylase catalytic
FB03_08630	COG3480	Lon protease (S16) C-terminal proteolytic domain
FB03_08635	COG1615	UPF0182 protein
FB03_08640	COG2056	Na+-H+ antiporter family
FB03_08675	COG0583	DNA-binding transcription factor activity
FB03_08735	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FB03_08750	COG1966	Carbon starvation protein
FB03_08770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FB03_08800	COG0114	fumarate hydratase activity
FB03_08815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FB03_08855	COG0395	ABC-type sugar transport system, permease component
FB03_08910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FB03_08915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FB03_08920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FB03_08925	COG0154	amidase activity
FB03_08955	COG4558	Periplasmic binding protein
FB03_08960	COG1132	(ABC) transporter
FB03_08970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FB03_08980	COG0129	dihydroxy-acid dehydratase activity
FB03_08985	COG2966	Psort location CytoplasmicMembrane, score
FB03_09000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FB03_09010	COG3830	Belongs to the UPF0237 family
FB03_09015	COG2848	UPF0210 protein
FB03_09025	COG0473	3-isopropylmalate dehydrogenase activity
FB03_09030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FB03_09035	COG0667	Aldo Keto reductase
FB03_09045	COG1518	maintenance of DNA repeat elements
FB03_09090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FB03_09095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FB03_09105	COG1120	ATPase activity
FB03_09145	COG0569	domain protein
FB03_09145	COG2985	domain, Protein