locus-tag	class	description
DDD63_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
DDD63_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
DDD63_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
DDD63_00020	ENOG4105K7N	UPF0232 protein
DDD63_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDD63_00030	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDD63_00060	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
DDD63_00080	ENOG4105C85	amino acid
DDD63_00090	ENOG4105CMT	Dihydroxyacetone kinase
DDD63_00095	ENOG4105CPQ	Dehydrogenase
DDD63_00120	ENOG4105D98	threonine synthase
DDD63_00125	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
DDD63_00150	ENOG4108U4N	(sortase) family
DDD63_00160	ENOG4105D9P	serine threonine protein kinase
DDD63_00165	ENOG4105CJN	penicillin-binding protein
DDD63_00180	ENOG4105HZM	Fha domain containing protein
DDD63_00185	ENOG4105IDI	abc transporter atp-binding protein
DDD63_00200	ENOG4105C28	cystathionine
DDD63_00210	ENOG4105BZ1	(ABC) transporter
DDD63_00215	ENOG4105BZ1	(ABC) transporter
DDD63_00230	ENOG4108UVJ	appr-1-p processing domain protein
DDD63_00235	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
DDD63_00300	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
DDD63_00305	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
DDD63_00325	ENOG4105EW4	(LipO)protein
DDD63_00335	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
DDD63_00340	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
DDD63_00350	ENOG4105C6T	cysteine synthase
DDD63_00390	ENOG4105C8P	)-transporter
DDD63_00420	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
DDD63_00430	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
DDD63_00515	ENOG4105CQ7	ATP-dependent helicase
DDD63_00520	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
DDD63_00525	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
DDD63_00530	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
DDD63_00615	ENOG4105C0A	alcohol dehydrogenase
DDD63_00645	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
DDD63_00650	ENOG4105C6Z	Gluconate
DDD63_00655	ENOG4105EQX	glucarate dehydratase
DDD63_00660	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
DDD63_00665	ENOG4105EQX	glucarate dehydratase
DDD63_00670	ENOG4105BZW	Glycerate kinase
DDD63_00735	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDD63_00770	ENOG4105CQ7	ATP-dependent helicase
DDD63_00775	ENOG4105NRA	50s ribosomal protein l31 type b
DDD63_00780	ENOG4105W0E	50S ribosomal protein L33
DDD63_00785	ENOG4105KDC	50s ribosomal protein l28
DDD63_00810	ENOG4105DIK	(ABC) transporter
DDD63_00820	ENOG4105C85	amino acid
DDD63_00835	ENOG4108RMH	femAB family
DDD63_00840	ENOG4105KT7	mgtC SapB transporter
DDD63_00875	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
DDD63_00880	ENOG4105BZU	Histidine kinase
DDD63_00890	ENOG4108Z6B	deaminase
DDD63_00895	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
DDD63_00905	ENOG4105C3Q	Glycosyl transferase, family 2
DDD63_00920	ENOG4105CQC	Prephenate dehydratase
DDD63_00925	ENOG4107TE5	Lipid kinase
DDD63_00930	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
DDD63_00935	ENOG4108KP7	hydrolase
DDD63_00960	ENOG4107UIY	sua5 ycio yrdc ywlc family protein
DDD63_01010	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
DDD63_01045	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
DDD63_01060	ENOG41060M0	Crispr-associated protein, cse4 family
DDD63_01080	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
DDD63_01115	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
DDD63_01120	ENOG410901E	Membrane
DDD63_01145	ENOG4108M15	ABC transporter
DDD63_01150	ENOG4105D49	3-dehydroquinate synthase
DDD63_01160	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
DDD63_01165	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
DDD63_01170	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
DDD63_01225	ENOG4105D74	hydrolase
DDD63_01275	ENOG4108I5C	dEAD DEAH box helicase
DDD63_01300	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
DDD63_01305	ENOG4107TTW	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
DDD63_01315	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
DDD63_01350	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
DDD63_01360	ENOG4108VJ1	Transcriptional regulator (CarD family
DDD63_01365	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
DDD63_01370	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
DDD63_01375	ENOG4105C8N	cysteinyl-tRNA synthetase
DDD63_01380	ENOG4105C2N	RNA methyltransferase TrmH family group 3
DDD63_01435	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
DDD63_01440	ENOG4105CFH	Aspartokinase
DDD63_01460	ENOG4108762	serine threonine protein kinase
DDD63_01505	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
DDD63_01520	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
DDD63_01560	ENOG4105CHR	reductase
DDD63_01570	ENOG4105BZU	Histidine kinase
DDD63_01575	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DDD63_01580	ENOG41087YS	Phage shock protein A
DDD63_01590	ENOG4105VEQ	Cold shock protein
DDD63_01600	ENOG4105EIP	mannose-6-phosphate isomerase
DDD63_01605	ENOG4105C7N	Xanthine uracil vitamin C permease
DDD63_01615	ENOG4107SFI	Major Facilitator superfamily
DDD63_01625	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
DDD63_01675	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
DDD63_01690	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
DDD63_01730	ENOG4106EES	
DDD63_01755	ENOG4105C1Q	protoporphyrinogen oxidase
DDD63_01825	ENOG4105CHR	reductase
DDD63_01835	ENOG4105CJ1	ABC, transporter
DDD63_01895	ENOG4107SWG	transcriptional regulator MERR family
DDD63_01900	ENOG4105CIG	ABC transporter
DDD63_01935	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
DDD63_01950	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
DDD63_01955	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
DDD63_01970	ENOG4105D52	delta-aminolevulinic acid dehydratase
DDD63_01975	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
DDD63_01990	ENOG4106H3A	restriction
DDD63_02035	ENOG4107QM2	Aldo Keto reductase
DDD63_02040	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
DDD63_02045	ENOG4105DKT	Transcriptional regulator
DDD63_02050	ENOG4108JB8	alcohol dehydrogenase
DDD63_02055	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
DDD63_02080	ENOG4105EQN	UPF0261 protein
DDD63_02090	ENOG4107RJJ	Transcriptional regulator
DDD63_02095	ENOG4105C26	Dehydrogenase
DDD63_02105	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
DDD63_02175	ENOG4108UMN	azlc family
DDD63_02180	ENOG4105E0A	ABC, transporter
DDD63_02185	ENOG4108MES	Periplasmic binding protein
DDD63_02190	ENOG4105DQ5	transport system permease protein
DDD63_02270	ENOG4105DWV	Homoserine O-trans-acetylase
DDD63_02290	ENOG4108IUE	nitrate reductase beta subunit
DDD63_02325	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
DDD63_02345	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
DDD63_02350	ENOG4105C0H	protease
DDD63_02370	ENOG4105CJ1	ABC, transporter
DDD63_02375	ENOG4105C26	Dehydrogenase
DDD63_02410	ENOG4108RWI	nicotinamidase
DDD63_02420	ENOG4105F8V	Hydrolase, tatD family
DDD63_02435	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
DDD63_02445	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
DDD63_02450	ENOG4105C5H	ABC transporter
DDD63_02455	ENOG4105DKT	Transcriptional regulator
DDD63_02460	ENOG4105CMG	Carbohydrate kinase
DDD63_02470	ENOG4108JQ1	Dehydrogenase
DDD63_02475	ENOG4105RHA	ABC transporter, permease
DDD63_02480	ENOG4108IUX	(ABC) transporter
DDD63_02525	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
DDD63_02530	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
DDD63_02560	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
DDD63_02565	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
DDD63_02605	ENOG4105CQB	FAD linked oxidase domain protein
DDD63_02625	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
DDD63_02660	ENOG4105CZV	ABC transporter
DDD63_02690	ENOG4108V1T	peptidylprolyl cis-trans isomerase
DDD63_02700	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
DDD63_02705	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
DDD63_02710	ENOG4105T1M	mycothiol conjugate amidase mca
DDD63_02715	ENOG4105CE4	GlcNAc 6-P deacetylase
DDD63_02725	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
DDD63_02730	ENOG4105CSR	polyphosphate kinase 2
DDD63_02740	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
DDD63_02790	ENOG4105C3G	gtp-binding protein
DDD63_02825	ENOG4107U9K	TROVE domain-containing protein
DDD63_02880	ENOG4105C1J	atp-dependent rna helicase
DDD63_02885	ENOG4105VT3	DNA binding domain protein, excisionase family
DDD63_02905	ENOG4105ESI	atpase involved in dna repair
DDD63_02920	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
DDD63_02935	ENOG4105C0D	helicase
DDD63_02940	ENOG4105C0D	helicase
DDD63_02955	ENOG4107RGM	aldo keto reductase
DDD63_02975	ENOG4105C5F	glutamine synthetase
DDD63_02980	ENOG4107QN2	dihydrolipoyl dehydrogenase
DDD63_03000	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
DDD63_03035	ENOG4105C85	amino acid
DDD63_03055	ENOG4105C8J	)-transporter
DDD63_03095	ENOG4105D22	carbon starvation protein
DDD63_03100	ENOG4105CK2	sodium dicarboxylate symporter
DDD63_03105	ENOG4105C85	amino acid
DDD63_03110	ENOG4108IQE	Amp-dependent synthetase and ligase
DDD63_03140	ENOG4105DA5	(ABC) transporter
DDD63_03165	ENOG4105DFM	M18 family aminopeptidase
DDD63_03200	ENOG4105CI3	gtp-binding protein typa
DDD63_03215	ENOG4108Z4U	Ferredoxin
DDD63_03230	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
DDD63_03235	ENOG4108JW7	Maf-like protein
DDD63_03260	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
DDD63_03265	ENOG4108KGH	TRANSCRIPTIONal
DDD63_03275	ENOG4108KGH	TRANSCRIPTIONal
DDD63_03290	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
DDD63_03295	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
DDD63_03315	ENOG4105CKK	Glycosyl transferase, family 2
DDD63_03325	ENOG4105MFV	ABC-2 type transporter
DDD63_03330	ENOG4105EY8	ABC transporter
DDD63_03345	ENOG4105CTC	Lipopolysaccharide biosynthesis protein-like protein
DDD63_03355	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
DDD63_03375	ENOG4105C09	Bile acid
DDD63_03380	ENOG4107T8Q	Glycosyl transferase (Group 1
DDD63_03400	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
DDD63_03410	ENOG4105ECY	inositol monophosphatase
DDD63_03415	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
DDD63_03440	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DDD63_03445	ENOG4105BZU	Histidine kinase
DDD63_03450	ENOG4105BZU	Histidine kinase
DDD63_03470	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
DDD63_03480	ENOG4108VPT	UPF0234 protein
DDD63_03500	ENOG4105WDJ	50S ribosomal protein L33
DDD63_03535	ENOG410683Z	Preprotein translocase SecE subunit
DDD63_03540	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
DDD63_03545	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
DDD63_03550	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
DDD63_03565	ENOG4108VZM	50s ribosomal protein L10
DDD63_03575	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DDD63_03580	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DDD63_03585	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
DDD63_03590	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
DDD63_03595	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
DDD63_03600	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
DDD63_03605	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
DDD63_03620	ENOG4105EF1	ribulokinase
DDD63_03630	ENOG4105FDP	GntR family transcriptional regulator
DDD63_03635	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
DDD63_03640	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
DDD63_03645	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
DDD63_03650	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
DDD63_03660	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
DDD63_03665	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
DDD63_03670	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
DDD63_03675	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
DDD63_03680	ENOG41082SA	50s ribosomal protein l29
DDD63_03685	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
DDD63_03695	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
DDD63_03700	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DDD63_03705	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
DDD63_03710	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
DDD63_03715	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
DDD63_03725	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
DDD63_03730	ENOG410849U	50S ribosomal protein L30
DDD63_03735	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
DDD63_03740	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
DDD63_03745	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
DDD63_03750	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
DDD63_03755	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
DDD63_03760	ENOG41067V7	50S ribosomal protein L36
DDD63_03765	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DDD63_03770	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
DDD63_03775	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DDD63_03780	ENOG4108ZT0	50S ribosomal protein l17
DDD63_03790	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
DDD63_03800	ENOG4108MDK	Dehydrogenase
DDD63_03805	ENOG4105EF1	ribulokinase
DDD63_03810	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
DDD63_03815	ENOG4108UJD	30S ribosomal protein S9
DDD63_03840	ENOG4105CS9	pantothenic acid kinase
DDD63_03850	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
DDD63_03860	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
DDD63_03865	ENOG4108097	ATP-binding protein
DDD63_03895	ENOG4105E33	succinate dehydrogenase
DDD63_03900	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
DDD63_03910	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
DDD63_03915	ENOG4107S1E	Beta-lactamase
DDD63_03920	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
DDD63_03925	ENOG4108JDX	DNA polymerase iii, epsilon subunit
DDD63_03990	ENOG4105CIZ	coA-substrate-specific enzyme activase
DDD63_04015	ENOG4108JGH	Tetr family transcriptional regulator
DDD63_04020	ENOG4105CIG	ABC transporter
DDD63_04025	ENOG4105DIM	ABC transporter
DDD63_04060	ENOG4105F2M	alpha beta hydrolase fold-3 domain protein
DDD63_04085	ENOG4105C54	Major Facilitator superfamily
DDD63_04105	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
DDD63_04115	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
DDD63_04120	ENOG4105C6K	Malic enzyme
DDD63_04135	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
DDD63_04180	ENOG4105CVR	type I restriction-modification system
DDD63_04195	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DDD63_04200	ENOG4108JSS	Haloalkane dehalogenase
DDD63_04275	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
DDD63_04300	ENOG4105C5X	domain protein
DDD63_04360	ENOG4105CJ1	ABC, transporter
DDD63_04370	ENOG4105WH1	Two component transcriptional regulator luxr family
DDD63_04385	ENOG4105DC1	bifunctional purine biosynthesis protein purh
DDD63_04405	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
DDD63_04410	ENOG4105CTQ	phosphohexokinase
DDD63_04420	ENOG4107QP8	phosphohexose isomerase
DDD63_04425	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
DDD63_04440	ENOG4105D8K	carboxyl transferase
DDD63_04455	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
DDD63_04460	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
DDD63_04470	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
DDD63_04475	ENOG4107TFB	basic membrane
DDD63_04485	ENOG4105UIB	(ABC) transporter
DDD63_04505	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
DDD63_04515	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
DDD63_04525	ENOG4108URH	decarboxylase
DDD63_04550	ENOG4105CJW	magnesium transporter
DDD63_04570	ENOG4105CM4	permease protein
DDD63_04575	ENOG4108IPW	abc transporter atp-binding protein
DDD63_04585	ENOG41081FY	multiple antibiotic resistance (MarC)-related
DDD63_04590	ENOG4105C1J	atp-dependent rna helicase
DDD63_04610	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
DDD63_04625	ENOG4105C4R	Atp-dependent dna helicase
DDD63_04675	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
DDD63_04680	ENOG4105CAK	Cell division ATP-binding protein ftsE
DDD63_04695	ENOG4105DR5	peptidase
DDD63_04700	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
DDD63_04710	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
DDD63_04730	ENOG4108426	dNA-binding protein
DDD63_04750	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
DDD63_04760	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
DDD63_04765	ENOG4108RQ5	Beta-lactamase domain-containing protein
DDD63_04775	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
DDD63_04790	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
DDD63_04805	ENOG4105CEY	Amp-dependent synthetase and ligase
DDD63_04815	ENOG4105C1G	acyl-Coa dehydrogenase
DDD63_04820	ENOG4108W9H	Tetr family transcriptional regulator
DDD63_04830	ENOG4105CIG	ABC transporter
DDD63_04840	ENOG4105C87	Aminotransferase class I and II
DDD63_04855	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
DDD63_04880	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
DDD63_04885	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
DDD63_04890	ENOG4105EPJ	extracellular solute-binding protein family 1
DDD63_04920	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
DDD63_04925	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
DDD63_04945	ENOG4105CPF	Cell wall formation (By similarity)
DDD63_04975	ENOG4105VB9	50S ribosomal protein l28
DDD63_04985	ENOG4106H78	methyltransferase
DDD63_04990	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
DDD63_05005	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
DDD63_05010	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
DDD63_05025	ENOG4105BZ1	(ABC) transporter
DDD63_05030	ENOG4108JJ9	ABC, transporter
DDD63_05035	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
DDD63_05040	ENOG4105C4M	(Ubiquinol oxidase) subunit I
DDD63_05045	ENOG4105C03	ribonuclease
DDD63_05050	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
DDD63_05055	ENOG4105K46	50S ribosomal protein l27
DDD63_05065	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
DDD63_05090	ENOG41080RH	Thioredoxin
DDD63_05095	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
DDD63_05100	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
DDD63_05115	ENOG4105CVJ	phosphoglycerate mutase
DDD63_05125	ENOG4105CTQ	phosphohexokinase
DDD63_05140	ENOG4107RSM	transcriptional regulator
DDD63_05170	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
DDD63_05185	ENOG4107R3N	Filamentation induced by cAMP protein fic
DDD63_05225	ENOG4105WH1	Two component transcriptional regulator luxr family
DDD63_05235	ENOG4105BZU	Histidine kinase
DDD63_05240	ENOG4105CJ1	ABC, transporter
DDD63_05255	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
DDD63_05275	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
DDD63_05280	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
DDD63_05295	ENOG41080QX	K07048 phosphotriesterase-related protein
DDD63_05320	ENOG4105C54	Major Facilitator superfamily
DDD63_05360	ENOG4105CEI	nitrite reductase
DDD63_05365	ENOG4105D01	(LipO)protein
DDD63_05370	ENOG4108UMI	ABC transporter, permease
DDD63_05375	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
DDD63_05385	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
DDD63_05405	ENOG4105E0A	ABC, transporter
DDD63_05410	ENOG4105TVJ	transport system, permease
DDD63_05415	ENOG4105DQ5	transport system permease protein
DDD63_05440	ENOG4105KQC	Competence protein
DDD63_05455	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
DDD63_05460	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
DDD63_05470	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
DDD63_05490	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
DDD63_05495	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
DDD63_05515	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
DDD63_05520	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
DDD63_05535	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
DDD63_05545	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
DDD63_05565	ENOG4105D9P	serine threonine protein kinase
DDD63_05575	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
DDD63_05580	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
DDD63_05585	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
DDD63_05590	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
DDD63_05610	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
DDD63_05620	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
DDD63_05625	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
DDD63_05635	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
DDD63_05640	ENOG41084BS	50S ribosomal protein L35
DDD63_05645	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
DDD63_05660	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
DDD63_05665	ENOG4105DDK	oxidoreductase, beta subunit
DDD63_05670	ENOG4105BZ8	glutamate synthase
DDD63_05680	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
DDD63_05715	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
DDD63_05720	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
DDD63_05735	ENOG4105C9M	aspartyl-trna synthetase
DDD63_05760	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
DDD63_05770	ENOG4105CPC	Aldo Keto reductase
DDD63_05775	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
DDD63_05780	ENOG4105C8N	cysteinyl-tRNA synthetase
DDD63_05785	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
DDD63_05790	ENOG4105CK7	Sodium proline symporter
DDD63_05800	ENOG4105EF1	ribulokinase
DDD63_05805	ENOG4105DKT	Transcriptional regulator
DDD63_05825	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
DDD63_05830	ENOG4105E5F	proteasome
DDD63_05840	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
DDD63_05855	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
DDD63_05870	ENOG4105DK0	Indole-3-glycerol phosphate synthase
DDD63_05875	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
DDD63_05905	ENOG4105KA0	thioesterase Superfamily protein
DDD63_05915	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
DDD63_05920	ENOG4105CH2	amidohydrolase
DDD63_05925	ENOG4108IDU	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
DDD63_05935	ENOG4105D01	(LipO)protein
DDD63_05945	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
DDD63_05955	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
DDD63_05960	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
DDD63_05975	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
DDD63_05985	ENOG4105D49	3-dehydroquinate synthase
DDD63_06005	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
DDD63_06010	ENOG410803B	Involved in the transcription termination process (By similarity)
DDD63_06015	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
DDD63_06020	ENOG4105CXT	aspartate transcarbamylase
DDD63_06025	ENOG4105CD3	dihydroorotase
DDD63_06035	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
DDD63_06040	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
DDD63_06045	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
DDD63_06055	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
DDD63_06080	ENOG4107RSZ	Primosomal protein n'
DDD63_06085	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
DDD63_06095	ENOG4105DJV	ribulose-phosphate 3-epimerase
DDD63_06100	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
DDD63_06105	ENOG4107XKF	NMT1 THI5 Like Domain Protein
DDD63_06110	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
DDD63_06115	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
DDD63_06145	ENOG4107R05	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
DDD63_06150	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
DDD63_06175	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
DDD63_06195	ENOG4108UW8	fha domain-containing protein
DDD63_06235	ENOG4105KNA	-acetyltransferase
DDD63_06250	ENOG4105C0B	DNA polymerase III (alpha subunit)
DDD63_06260	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
DDD63_06280	ENOG4105D7K	pfkb domain protein
DDD63_06285	ENOG4108UHU	Aldolase
DDD63_06290	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
DDD63_06295	ENOG4105DEI	Mannitol dehydrogenase
DDD63_06305	ENOG4108V1U	phospholipid-binding protein
DDD63_06310	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
DDD63_06335	ENOG4105DKW	ABC transporter
DDD63_06345	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
DDD63_06370	ENOG4105C5H	ABC transporter
DDD63_06380	ENOG4105VG1	fes assembly suf system protein
DDD63_06395	ENOG4105C3K	feS assembly ATPase SufC
DDD63_06405	ENOG4105JRK	feS assembly protein SufD
DDD63_06430	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
DDD63_06435	ENOG4105CJR	Integral membrane protein (MviN
DDD63_06455	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
DDD63_06460	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
DDD63_06470	ENOG4105DSU	hydrolase
DDD63_06495	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
DDD63_06505	ENOG4108VX5	3-methyladenine DNA glycosylase
DDD63_06510	ENOG4105CH7	arginosuccinase
DDD63_06515	ENOG4105DBV	ornithine carbamoyltransferase
DDD63_06520	ENOG4108DBC	nitroreductase
DDD63_06525	ENOG4105CDH	Citrulline--aspartate ligase
DDD63_06535	ENOG4105C8Y	Acetylornithine aminotransferase
DDD63_06540	ENOG4105CAS	nag kinase
DDD63_06545	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
DDD63_06550	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
DDD63_06565	ENOG4105CUT	histidyl-tRNA synthetase
DDD63_06575	ENOG4105C99	atpase involved in dna repair
DDD63_06580	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
DDD63_06585	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
DDD63_06590	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
DDD63_06595	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
DDD63_06605	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
DDD63_06610	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
DDD63_06615	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
DDD63_06620	ENOG4105CDY	transcriptional regulatory protein
DDD63_06625	ENOG41062IR	nudix hydrolase
DDD63_06640	ENOG4105E2K	Glycosyl transferase (Group 1
DDD63_06645	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
DDD63_06655	ENOG4105C22	threonyL-tRNA synthetase
DDD63_06710	ENOG4105DRS	transport system, permease
DDD63_06720	ENOG4105ETE	Transcriptional regulator (LacI family
DDD63_06750	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
DDD63_06760	ENOG4107QM5	aconitate hydratase
DDD63_06765	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
DDD63_06780	ENOG4107VEG	TrkA-N domain protein
DDD63_06815	ENOG4107W53	thymidine kinase
DDD63_06840	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDD63_06845	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDD63_06855	ENOG4108JDX	DNA polymerase iii, epsilon subunit
DDD63_06860	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DDD63_06880	ENOG41068JE	domain protein
DDD63_06890	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
DDD63_06940	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
DDD63_06950	ENOG4108I0Q	anthranilate phosphoribosyltransferase
DDD63_06960	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
DDD63_06965	ENOG41081K0	peptidylprolyl cis-trans isomerase
DDD63_06980	ENOG4107S4Y	M20 DapE family protein YgeY
DDD63_06990	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
DDD63_07025	ENOG4105C5F	glutamine synthetase
DDD63_07030	ENOG4105EAB	amino acid AbC transporter
DDD63_07045	ENOG4105GCF	PGAM
DDD63_07050	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
DDD63_07055	ENOG4105C5F	glutamine synthetase
DDD63_07065	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
DDD63_07090	ENOG4105EGD	dinuclear metal center protein, YbgI family
DDD63_07100	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDD63_07125	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
DDD63_07150	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
DDD63_07165	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
DDD63_07215	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
DDD63_07220	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
DDD63_07250	ENOG4105DSE	periplasmic solute binding protein
DDD63_07265	ENOG41090R7	Ferric uptake
DDD63_07305	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
DDD63_07310	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
DDD63_07325	ENOG4105DFU	Cell wall formation (By similarity)
DDD63_07330	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
DDD63_07335	ENOG4105CNI	cell division protein FtsW
DDD63_07345	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
DDD63_07370	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
DDD63_07375	ENOG4108V6E	Cell division protein mraZ
DDD63_07385	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
DDD63_07405	ENOG4108JQ1	Dehydrogenase
DDD63_07455	ENOG4105CEY	Amp-dependent synthetase and ligase
DDD63_07460	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
DDD63_07470	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
DDD63_07485	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
DDD63_07490	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
DDD63_07495	ENOG4105NX3	Membrane
DDD63_07505	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
DDD63_07510	ENOG4105KC9	Modulates RecA activity (By similarity)
DDD63_07525	ENOG4105WBV	Transcriptional regulator
DDD63_07530	ENOG4105CEV	competence damage-inducible protein
DDD63_07555	ENOG4105CN5	Metallo-Beta-Lactamase
DDD63_07560	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
DDD63_07570	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
DDD63_07575	ENOG4105C1V	Peptidase, M16
DDD63_07580	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
DDD63_07585	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
DDD63_07600	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
DDD63_07605	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
DDD63_07610	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
DDD63_07610	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
DDD63_07630	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
DDD63_07690	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
DDD63_07705	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
DDD63_07740	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
DDD63_07755	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
DDD63_07765	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
DDD63_07785	ENOG4108R3E	Dna-3-methyladenine glycosylase i
DDD63_07795	ENOG4105CAG	UPF0210 protein
DDD63_07815	ENOG4105CE9	30S ribosomal protein S2
DDD63_07825	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DDD63_07835	ENOG4105C0P	Mg chelatase subunit ChlI
DDD63_07840	ENOG41080R2	UPF0102 protein
DDD63_07850	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
DDD63_07855	ENOG4107QYR	Signal peptidase i
DDD63_07860	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
DDD63_07865	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
DDD63_07870	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
DDD63_07875	ENOG41082KU	UPF0109 protein
DDD63_07880	ENOG4105K5M	30s ribosomal protein S16
DDD63_07905	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DDD63_07940	ENOG4105E90	ABC transporter
DDD63_07950	ENOG4108IJ8	ABC transporter
DDD63_08010	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
DDD63_08015	ENOG4105CAT	Cytidine monophosphate kinase
DDD63_08025	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
DDD63_08030	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
DDD63_08055	ENOG4105CP7	Triose-phosphate isomerase
DDD63_08060	ENOG4105BZA	Phosphoglycerate kinase
DDD63_08065	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
DDD63_08070	ENOG4105CIE	May be required for sporulation (By similarity)
DDD63_08075	ENOG4105CHW	UPF0052 protein
DDD63_08105	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
DDD63_08110	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
DDD63_08115	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
DDD63_08120	ENOG4105CV8	reductase
DDD63_08125	ENOG4107YVI	ribose 5-phosphate isomerase
DDD63_08135	ENOG4105HF0	Membrane
DDD63_08170	ENOG4108UTZ	Dihydroxyacetone kinase
DDD63_08175	ENOG4105CMT	Dihydroxyacetone kinase
DDD63_08185	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
DDD63_08190	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
DDD63_08215	ENOG4108IQE	Amp-dependent synthetase and ligase
DDD63_08220	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
DDD63_08225	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
DDD63_08230	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
DDD63_08235	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
DDD63_08265	ENOG4105EIY	sodium-type flagellar protein motY
DDD63_08290	ENOG4105EYF	MMPL domain protein
DDD63_08320	ENOG41068HZ	50S ribosomal protein L32
DDD63_08325	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
DDD63_08330	ENOG4105C6T	cysteine synthase
DDD63_08335	ENOG4105D7W	serine acetyltransferase
DDD63_08385	ENOG4105C5Y	PTS System
DDD63_08390	ENOG4105CI1	PTS System
DDD63_08400	ENOG4105C29	acyl-CoA thioesterase
DDD63_08405	ENOG4105F1A	Pyruvate formate-lyase
DDD63_08415	ENOG4105C6N	Formate acetyltransferase
DDD63_08425	ENOG4105CHR	reductase
DDD63_08465	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
DDD63_08480	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
DDD63_08485	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
DDD63_08495	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDD63_08520	ENOG4105D7K	pfkb domain protein
DDD63_08525	ENOG4105C2C	drug resistance transporter, Bcr CflA
DDD63_08545	ENOG4108ZHJ	Organic hydroperoxide resistance protein
DDD63_08645	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
DDD63_08650	ENOG4107R39	(ABC) transporter
DDD63_08660	ENOG4108WQH	regulatoR
DDD63_08685	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
DDD63_08690	ENOG4105CM2	brancheD-chain amino acid aminotransferase
DDD63_08695	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
DDD63_08715	ENOG4108UB4	uncharacterized protein ygjQ
DDD63_08720	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
DDD63_08740	ENOG4105D0C	transport protein
DDD63_08745	ENOG4105C01	Dihydroxy-acid dehydratase
DDD63_08750	ENOG4105BZ1	(ABC) transporter
DDD63_08765	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
DDD63_08770	ENOG4105EHG	Permease protein
DDD63_08810	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
DDD63_08815	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
DDD63_08820	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
DDD63_08825	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
DDD63_08835	ENOG4108RAV	Conserved protein
DDD63_08860	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
DDD63_08865	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
DDD63_08875	ENOG4105BZ1	(ABC) transporter
DDD63_08890	ENOG4105C9Q	fumarate hydratase class II
DDD63_08925	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
DDD63_08940	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DDD63_08975	ENOG4105E4C	Lytic transglycosylase catalytic
DDD63_09045	ENOG4105DJZ	UPF0182 protein
DDD63_09055	ENOG41063PX	domain protein
DDD63_09080	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
DDD63_09095	ENOG4105C31	Tryptophanyl-tRNA synthetase
DDD63_09115	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
DDD63_09120	ENOG4105EG2	ABC transporter, permease
DDD63_09125	ENOG4105D56	permease protein
DDD63_09175	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
DDD63_09185	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
DDD63_09190	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
DDD63_09200	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
DDD63_09205	ENOG4108SBS	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
DDD63_09210	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
DDD63_09215	ENOG4105ZA1	atp synthase
DDD63_09220	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
DDD63_09230	ENOG4105ESV	Glycosyl transferase, family 4
DDD63_09235	ENOG4107UIY	sua5 ycio yrdc ywlc family protein
DDD63_09240	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
DDD63_09245	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
DDD63_09250	ENOG4105VFB	Binds the 23S rRNA (By similarity)
DDD63_09260	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
DDD63_09265	ENOG4105D6E	homoserine dehydrogenase
DDD63_09280	ENOG4105EMV	Major Facilitator
DDD63_09295	ENOG4105C75	arginyL-tRNA synthetase
DDD63_09310	ENOG4105E4C	Lytic transglycosylase catalytic
DDD63_09330	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
DDD63_09355	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
DDD63_09375	ENOG4105EYH	Exonuclease
DDD63_09380	ENOG4105EYH	Exonuclease
DDD63_09385	ENOG4105EYH	Exonuclease
DDD63_09425	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
DDD63_09430	ENOG4105CGH	5'-nucleotidase
DDD63_09440	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDD63_09450	ENOG4105D65	subunit l
DDD63_09455	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDD63_09460	ENOG4107UFS	subunit j
DDD63_09465	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDD63_09470	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
DDD63_09475	ENOG4108IEH	NADH dehydrogenase subunit g
DDD63_09480	ENOG4107QIZ	NADH dehydrogenase
DDD63_09490	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDD63_09495	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DDD63_09500	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDD63_09510	ENOG4105P52	geranylgeranyl reductase
DDD63_09515	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
DDD63_09550	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
DDD63_09590	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
DDD63_09600	ENOG4105CEN	a g-specific adenine glycosylase
DDD63_09625	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
DDD63_09635	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
DDD63_09655	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
DDD63_09665	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
DDD63_09700	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
DDD63_09710	ENOG4105EF1	ribulokinase
DDD63_09715	ENOG4108MDK	Dehydrogenase
DDD63_09725	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
DDD63_09740	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
DDD63_09745	ENOG4105DAA	L-lactate
DDD63_09760	ENOG41080R8	Conserved Protein
DDD63_09805	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
DDD63_09810	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
DDD63_09835	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DDD63_09840	ENOG4105EEI	dihydropteroate synthase
DDD63_09860	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
DDD63_09870	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
DDD63_09910	ENOG4108IQK	o-acetylhomoserine
DDD63_09925	ENOG4105CQB	FAD linked oxidase domain protein
DDD63_09935	ENOG4105CE1	Ferrous iron transport protein b
DDD63_09945	ENOG4105MVE	transcriptional regulator
DDD63_09950	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
DDD63_09955	ENOG4105G63	Type III effector Hrp-dependent
DDD63_09960	ENOG4105C6Z	Gluconate
DDD63_09985	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
DDD63_09990	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
DDD63_10000	ENOG4105C2J	ABC transporter
DDD63_10005	ENOG4105CNN	ABC, transporter
DDD63_10010	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
DDD63_10015	ENOG4107Z96	xylose isomerase
DDD63_10020	ENOG4108HHA	Transketolase
DDD63_10040	ENOG4105NWF	RbsD or FucU transport
DDD63_10060	ENOG4105CMT	Dihydroxyacetone kinase
DDD63_10080	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
DDD63_10085	ENOG4107HP6	Transcriptional regulator
DDD63_10100	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
DDD63_10105	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
DDD63_10120	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
DDD63_10125	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
DDD63_10140	ENOG4105CJ3	phosphate transporter
DDD63_10150	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
DDD63_10155	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
DDD63_10175	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
DDD63_10190	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
DDD63_10200	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
DDD63_10205	ENOG4107QW3	Sucrose phosphorylase
DDD63_10240	ENOG4105E0X	reductase
DDD63_10265	ENOG4105CWC	Acetylornithine deacetylase
DDD63_10280	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
DDD63_10300	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
DDD63_10315	ENOG4105CGH	5'-nucleotidase
DDD63_10320	ENOG4105D82	Glutamate dehydrogenase
DDD63_10330	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
DDD63_10335	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
DDD63_10345	ENOG4105C8V	SAICAR synthetase
DDD63_10350	ENOG4105C12	Phosphoribosylglycinamide synthetase
DDD63_10355	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
DDD63_10415	ENOG4107RCW	fructose-bisphosphate aldolase
DDD63_10435	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
DDD63_10485	ENOG4108JJB	ABC transporter
DDD63_10500	ENOG4105C1G	acyl-Coa dehydrogenase
DDD63_10505	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
DDD63_10510	ENOG4105FCD	Major Facilitator
DDD63_10515	ENOG4105CEY	Amp-dependent synthetase and ligase
DDD63_10540	ENOG4105DTD	Dehydrogenase
DDD63_10570	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
DDD63_10585	ENOG4105EC2	ftsk spoIIIe
DDD63_10605	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
DDD63_10610	ENOG4108IG5	Transcriptional regulator
DDD63_10695	ENOG4108Z66	YbaK ebsC protein
DDD63_10710	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
DDD63_10715	ENOG4105CTZ	aminopeptidase c
DDD63_10790	ENOG4105ECQ	AraC Family Transcriptional Regulator
DDD63_10795	ENOG4108KD5	ADP-ribosylation crystallin J1
DDD63_10825	ENOG4107T8Q	Glycosyl transferase (Group 1
DDD63_10855	ENOG4105BZU	Histidine kinase
DDD63_10860	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DDD63_10870	ENOG4105KNI	merR family transcriptional Regulator
DDD63_10875	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
DDD63_10880	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DDD63_10885	ENOG4105CFG	Acts as a chaperone (By similarity)
DDD63_10920	ENOG4105DKQ	ROK family
DDD63_10930	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
DDD63_10945	ENOG4105KPY	Small multidrug resistance protein
DDD63_10970	ENOG4105CJ1	ABC, transporter
DDD63_10980	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
DDD63_10995	ENOG4108UCS	ABC, transporter
DDD63_11030	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
DDD63_11050	ENOG410836F	Transposase
DDD63_11075	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDD63_11115	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
DDD63_11140	ENOG4107TXC	Transcriptional regulator
DDD63_11150	ENOG41082T9	Membrane
DDD63_11165	ENOG4107QTF	adenylosuccinate lyase
DDD63_11170	ENOG4107T5V	SNARE associated Golgi
DDD63_11175	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
DDD63_11185	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDD63_11215	ENOG4105E2A	Dehydrogenase
DDD63_11260	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
DDD63_11265	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
DDD63_11270	ENOG4105C01	Dihydroxy-acid dehydratase
DDD63_11275	ENOG4108TZY	GntR Family Transcriptional Regulator
DDD63_11280	ENOG4105DEI	Mannitol dehydrogenase
DDD63_11285	ENOG4105C6Z	Gluconate
DDD63_11315	ENOG4105WH1	Two component transcriptional regulator luxr family
DDD63_11325	ENOG4108UVJ	appr-1-p processing domain protein
DDD63_11365	ENOG4105D9P	serine threonine protein kinase
DDD63_11405	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
DDD63_11440	ENOG4108UHU	Aldolase
DDD63_11470	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
DDD63_11565	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
DDD63_11570	ENOG4105CV8	reductase
DDD63_11580	ENOG4105DWF	phosphomethylpyrimidine kinase
DDD63_11600	ENOG4105CDU	Replicative dna helicase
DDD63_11605	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
DDD63_11615	ENOG4105HDK	L-asparaginase
DDD63_11620	ENOG41060W2	glyoxylate carboligase
DDD63_11630	ENOG4108IUS	Transketolase
DDD63_11645	ENOG4105CXT	aspartate transcarbamylase
DDD63_11655	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
DDD63_11665	ENOG410633P	Hydantoin racemase
DDD63_11670	ENOG41069M3	Transcriptional regulator
DDD63_11680	ENOG4105ETE	Transcriptional regulator (LacI family
DDD63_11685	ENOG4107WI4	Aldose-1-epimerase
DDD63_11695	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
DDD63_11710	ENOG4105CMR	udp-glucose 4-epimerase
DDD63_11720	ENOG4105C6Z	Gluconate
DDD63_11725	ENOG4105ZXK	Dehydrogenase
DDD63_11735	ENOG4105JXH	GntR family transcriptional regulator
DDD63_11740	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
DDD63_11745	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
DDD63_11750	ENOG4107YH6	single-stranded DNA-binding protein
DDD63_11755	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
DDD63_11760	ENOG4105BZ4	penicillin-binding protein
DDD63_11765	ENOG4105DSF	transport protein
DDD63_11830	ENOG4105C3M	thioredoxin reductase
DDD63_11840	ENOG4105C3M	thioredoxin reductase
DDD63_11865	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
DDD63_11880	ENOG4107QJE	Chromosome Partitioning Protein
DDD63_11885	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
DDD63_11900	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
DDD63_11905	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
DDD63_11910	ENOG4105XH8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)