locus-tag	class	description
MRB58_00010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MRB58_00015	COG0351	phosphomethylpyrimidine kinase
MRB58_00020	COG0352	thiamine-phosphate diphosphorylase activity
MRB58_00040	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MRB58_00055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MRB58_00060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MRB58_00065	COG2197	response regulator
MRB58_00100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MRB58_00110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_00165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MRB58_00205	COG1116	anion transmembrane transporter activity
MRB58_00205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MRB58_00210	COG0010	Belongs to the arginase family
MRB58_00220	COG3214	Protein conserved in bacteria
MRB58_00250	COG0395	ABC-type sugar transport system, permease component
MRB58_00260	COG3842	ATPase activity
MRB58_00265	COG3842	ATPase activity
MRB58_00295	COG1522	sequence-specific DNA binding
MRB58_00320	COG0175	sulfate reduction
MRB58_00325	COG0179	Fumarylacetoacetate (FAA) hydrolase
MRB58_00330	COG3483	tryptophan 2,3-dioxygenase activity
MRB58_00340	COG0248	Ppx GppA phosphatase
MRB58_00355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MRB58_00360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MRB58_00370	COG1126	abc transporter atp-binding protein
MRB58_00375	COG0765	amino acid transport
MRB58_00380	COG0765	amino acid transport
MRB58_00390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MRB58_00395	COG4942	peptidase
MRB58_00400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MRB58_00405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MRB58_00415	COG0747	negative chemotaxis
MRB58_00420	COG0601	transmembrane transport
MRB58_00425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_00430	COG0444	Belongs to the ABC transporter superfamily
MRB58_00435	COG4608	Belongs to the ABC transporter superfamily
MRB58_00450	COG3218	ABC-type transport auxiliary lipoprotein component
MRB58_00450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MRB58_00455	COG1127	ABC transporter
MRB58_00460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MRB58_00470	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_00480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MRB58_00490	COG0463	Glycosyl transferase, family 2
MRB58_00500	COG0626	cystathionine gamma-synthase activity
MRB58_00505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MRB58_00510	COG4597	amino acid ABC transporter
MRB58_00515	COG0765	amino acid transport
MRB58_00520	COG1126	abc transporter atp-binding protein
MRB58_00535	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MRB58_00535	COG0662	Cupin 2, conserved barrel domain protein
MRB58_00545	COG0183	Belongs to the thiolase family
MRB58_00550	COG1024	Enoyl-CoA hydratase
MRB58_00560	COG1960	acyl-CoA dehydrogenase activity
MRB58_00580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MRB58_00590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MRB58_00595	COG1960	acyl-CoA dehydrogenase activity
MRB58_00600	COG1309	transcriptional regulator
MRB58_00610	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_00640	COG4251	negative regulation of phosphorylation
MRB58_00645	COG0784	Response regulator, receiver
MRB58_00650	COG2204	response regulator
MRB58_00655	COG4251	negative regulation of phosphorylation
MRB58_00660	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MRB58_00670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MRB58_00715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MRB58_00720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MRB58_00735	COG0509	glycine decarboxylation via glycine cleavage system
MRB58_00740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MRB58_00745	COG2070	2-Nitropropane dioxygenase
MRB58_00750	COG2030	dehydratase
MRB58_00755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_00760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_00775	COG0277	FAD linked oxidase domain protein
MRB58_00790	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_00800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_00825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MRB58_00835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MRB58_00845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MRB58_00855	COG0195	Participates in both transcription termination and antitermination
MRB58_00855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MRB58_00860	COG0779	Required for maturation of 30S ribosomal subunits
MRB58_00865	COG0494	nUDIX hydrolase
MRB58_00870	COG0386	Belongs to the glutathione peroxidase family
MRB58_00880	COG0372	Belongs to the citrate synthase family
MRB58_00890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MRB58_00900	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MRB58_00915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MRB58_00920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MRB58_00925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MRB58_00930	COG0750	zinc metalloprotease
MRB58_00935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MRB58_00945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MRB58_00950	COG0233	cytoplasmic translational termination
MRB58_00955	COG0528	UMP kinase activity
MRB58_00960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MRB58_00965	COG0288	reversible hydration of carbon dioxide
MRB58_00970	COG0028	Belongs to the TPP enzyme family
MRB58_01000	COG0519	Catalyzes the synthesis of GMP from XMP
MRB58_01005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MRB58_01020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_01025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_01040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_01065	COG0052	Belongs to the universal ribosomal protein uS2 family
MRB58_01080	COG2010	Cytochrome c
MRB58_01085	COG0330	HflC and HflK could
MRB58_01100	COG0024	Methionine aminopeptidase
MRB58_01105	COG2003	Belongs to the UPF0758 family
MRB58_01110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MRB58_01115	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MRB58_01145	COG5265	(ABC) transporter
MRB58_01150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MRB58_01155	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
MRB58_01170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MRB58_01295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MRB58_01310	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
MRB58_01325	COG1176	ABC-type spermidine putrescine transport system, permease component I
MRB58_01330	COG0395	ABC-type sugar transport system, permease component
MRB58_01335	COG0366	Alpha amylase catalytic
MRB58_01350	COG0395	ABC-type sugar transport system, permease component
MRB58_01365	COG0786	glutamate:sodium symporter activity
MRB58_01425	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_01430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRB58_01435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_01445	COG2183	response to ionizing radiation
MRB58_01460	COG1183	phosphatidylcholine synthase activity
MRB58_01475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MRB58_01480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MRB58_01485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MRB58_01495	COG0649	NAD binding
MRB58_01505	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MRB58_01530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_01555	COG1024	Enoyl-CoA hydratase
MRB58_01600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MRB58_01605	COG0791	NLP P60 protein
MRB58_01620	COG0583	DNA-binding transcription factor activity
MRB58_01625	COG4794	Type iii secretion
MRB58_01630	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MRB58_01660	COG1157	protein secretion by the type III secretion system
MRB58_01675	COG0243	molybdopterin cofactor binding
MRB58_01720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MRB58_01780	COG0697	spore germination
MRB58_01825	COG2268	Band 7 protein
MRB58_01825	COG2268	Band 7 protein
MRB58_01830	COG0135	phosphoribosylanthranilate isomerase activity
MRB58_01835	COG5564	TIM-barrel signal transduction protein
MRB58_01840	COG5441	Belongs to the UPF0261 family
MRB58_01855	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_01870	COG0183	Belongs to the thiolase family
MRB58_01880	COG1178	ABC-type Fe3 transport system permease component
MRB58_01885	COG1902	pentaerythritol trinitrate reductase activity
MRB58_01885	COG0446	pyridine nucleotide-disulphide oxidoreductase
MRB58_01920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MRB58_01920	COG0446	pyridine nucleotide-disulphide oxidoreductase
MRB58_01945	COG0025	NhaP-type Na H and K H
MRB58_01955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_01960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_01960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_01965	COG2084	Dehydrogenase
MRB58_01970	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_02030	COG2188	Transcriptional regulator
MRB58_02040	COG0402	S-adenosylhomocysteine deaminase activity
MRB58_02055	COG2259	Doxx family
MRB58_02070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_02110	COG1309	transcriptional regulator
MRB58_02140	COG4191	Histidine kinase
MRB58_02145	COG4566	intracellular signal transduction
MRB58_02165	COG0683	leucine binding
MRB58_02210	COG2358	TRAP transporter, solute receptor (TAXI family
MRB58_02230	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_02235	COG1802	Transcriptional regulator
MRB58_02240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_02325	COG0747	negative chemotaxis
MRB58_02330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_02335	COG0601	transmembrane transport
MRB58_02350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRB58_02355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MRB58_02365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MRB58_02370	COG0800	Aldolase
MRB58_02380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MRB58_02380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MRB58_02435	COG0356	it plays a direct role in the translocation of protons across the membrane
MRB58_02440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MRB58_02445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MRB58_02450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MRB58_02460	COG2264	protein methyltransferase activity
MRB58_02470	COG0006	proline dipeptidase activity
MRB58_02475	COG0028	Belongs to the TPP enzyme family
MRB58_02485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MRB58_02520	COG1280	lysine exporter protein (LysE YggA)
MRB58_02530	COG1846	Transcriptional regulator
MRB58_02550	COG1737	Transcriptional regulator
MRB58_02550	COG0837	glucose binding
MRB58_02560	COG3964	amidohydrolase
MRB58_02570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_02580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_02585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MRB58_02605	COG0837	glucose binding
MRB58_02625	COG0583	DNA-binding transcription factor activity
MRB58_02635	COG0535	radical SAM domain protein
MRB58_02640	COG3791	Glutathione-dependent formaldehyde-activating
MRB58_02650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRB58_02655	COG1280	lysine exporter protein (LysE YggA)
MRB58_02665	COG1012	belongs to the aldehyde dehydrogenase family
MRB58_02685	COG0538	isocitrate dehydrogenase activity
MRB58_02705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MRB58_02715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MRB58_02740	COG0765	amino acid transport
MRB58_02745	COG0765	amino acid transport
MRB58_02780	COG2814	Major facilitator Superfamily
MRB58_02795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MRB58_02800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MRB58_02810	COG0069	glutamate synthase activity
MRB58_02810	COG0067	glutamate synthase
MRB58_02810	COG0070	glutamate synthase
MRB58_02815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_02825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_02835	COG0488	(ABC) transporter
MRB58_02850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MRB58_02855	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MRB58_02860	COG0101	tRNA pseudouridine synthase activity
MRB58_02870	COG0242	peptide deformylase activity
MRB58_02905	COG5425	PFAM Usg family protein
MRB58_02910	COG1295	ribonuclease BN
MRB58_02925	COG2133	pyrroloquinoline quinone binding
MRB58_02935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MRB58_02940	COG1024	Enoyl-CoA hydratase
MRB58_02940	COG1250	3-hydroxyacyl-CoA dehydrogenase
MRB58_02960	COG2855	membrane
MRB58_02995	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_03005	COG2268	Band 7 protein
MRB58_03010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MRB58_03015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_03030	COG5001	Diguanylate cyclase
MRB58_03040	COG1802	Transcriptional regulator
MRB58_03070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MRB58_03080	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MRB58_03095	COG2226	methyltransferase
MRB58_03100	COG0215	cysteine-tRNA ligase activity
MRB58_03115	COG2204	response regulator
MRB58_03120	COG3852	Histidine kinase
MRB58_03125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MRB58_03130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MRB58_03130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MRB58_03135	COG1058	Belongs to the CinA family
MRB58_03135	COG1546	Belongs to the CinA family
MRB58_03150	COG0142	geranyltranstransferase activity
MRB58_03175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MRB58_03210	COG0789	Transcriptional regulator
MRB58_03215	COG0402	S-adenosylhomocysteine deaminase activity
MRB58_03235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MRB58_03240	COG1349	DNA-binding transcription factor activity
MRB58_03245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MRB58_03250	COG3842	ATPase activity
MRB58_03255	COG1176	ABC-type spermidine putrescine transport system, permease component I
MRB58_03260	COG1177	transmembrane transport
MRB58_03270	COG0402	S-adenosylhomocysteine deaminase activity
MRB58_03275	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_03290	COG0747	negative chemotaxis
MRB58_03295	COG0601	transmembrane transport
MRB58_03300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_03330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_03335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MRB58_03335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_03360	COG3842	ATPase activity
MRB58_03390	COG0437	4 iron, 4 sulfur cluster binding
MRB58_03395	COG0243	molybdopterin cofactor binding
MRB58_03395	COG3383	formate dehydrogenase (NAD+) activity
MRB58_03430	COG0489	protein tyrosine kinase activity
MRB58_03455	COG2072	flavoprotein involved in K transport
MRB58_03475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MRB58_03485	COG0477	Major facilitator Superfamily
MRB58_03500	COG0504	CTP synthase activity
MRB58_03505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MRB58_03520	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_03530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRB58_03540	COG0751	glycine-tRNA ligase activity
MRB58_03565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MRB58_03585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MRB58_03590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MRB58_03605	COG0085	RNA polymerase activity
MRB58_03610	COG0222	ribosome binding
MRB58_03615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MRB58_03625	COG0081	regulation of translation
MRB58_03630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MRB58_03650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MRB58_03670	COG0154	amidase activity
MRB58_03680	COG1132	(ABC) transporter
MRB58_03730	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_03740	COG2188	Transcriptional regulator
MRB58_03745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MRB58_03750	COG5001	Diguanylate cyclase
MRB58_03750	COG3300	MHYT domain
MRB58_03785	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_03800	COG1129	ABC transporter
MRB58_03805	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_03820	COG2205	protein histidine kinase activity
MRB58_03830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MRB58_03835	COG1845	cytochrome c oxidase, subunit III
MRB58_03840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MRB58_03845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MRB58_03850	COG0477	Major facilitator Superfamily
MRB58_03865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MRB58_03870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MRB58_03885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_03895	COG3938	Belongs to the proline racemase family
MRB58_03900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MRB58_03960	COG0145	ligase activity
MRB58_03975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_03975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_03980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_03995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_04010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_04015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_04020	COG0673	inositol 2-dehydrogenase activity
MRB58_04025	COG4689	acetoacetate decarboxylase
MRB58_04035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MRB58_04040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MRB58_04045	COG1116	anion transmembrane transporter activity
MRB58_04065	COG4211	Belongs to the binding-protein-dependent transport system permease family
MRB58_04070	COG1079	Belongs to the binding-protein-dependent transport system permease family
MRB58_04085	COG2267	carboxylic ester hydrolase activity
MRB58_04100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MRB58_04110	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_04115	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_04130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_04150	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_04160	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_04165	COG0371	Dehydrogenase
MRB58_04170	COG0395	ABC-type sugar transport system, permease component
MRB58_04175	COG1175	transmembrane transport
MRB58_04185	COG3842	ATPase activity
MRB58_04195	COG0277	FAD linked oxidase domain protein
MRB58_04200	COG1609	Transcriptional regulator
MRB58_04215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_04235	COG0564	pseudouridine synthase activity
MRB58_04245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MRB58_04255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MRB58_04260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MRB58_04265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MRB58_04275	COG3791	Glutathione-dependent formaldehyde-activating
MRB58_04280	COG0557	exoribonuclease II activity
MRB58_04305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MRB58_04310	COG0784	Response regulator, receiver
MRB58_04320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MRB58_04330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MRB58_04345	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MRB58_04425	COG1131	(ABC) transporter
MRB58_04445	COG1116	anion transmembrane transporter activity
MRB58_04455	COG3383	formate dehydrogenase (NAD+) activity
MRB58_04470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRB58_04495	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_04500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MRB58_04535	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_04545	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MRB58_04565	COG1984	allophanate hydrolase subunit 2
MRB58_04570	COG2301	Belongs to the HpcH HpaI aldolase family
MRB58_04585	COG0105	UTP biosynthetic process
MRB58_04595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MRB58_04600	COG0488	(ABC) transporter
MRB58_04615	COG0726	polysaccharide deacetylase
MRB58_04640	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MRB58_04645	COG0129	dihydroxy-acid dehydratase activity
MRB58_04655	COG1703	isobutyryl-CoA mutase activity
MRB58_04660	COG2200	EAL domain
MRB58_04665	COG1132	(ABC) transporter
MRB58_04695	COG0625	glutathione transferase activity
MRB58_04700	COG3842	ATPase activity
MRB58_04745	COG2084	Dehydrogenase
MRB58_04775	COG0587	DNA-directed DNA polymerase activity
MRB58_04795	COG0138	bifunctional purine biosynthesis protein purh
MRB58_04805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MRB58_04805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MRB58_04810	COG0501	Belongs to the peptidase M48B family
MRB58_04820	COG0617	tRNA 3'-terminal CCA addition
MRB58_04830	COG0494	nUDIX hydrolase
MRB58_04840	COG0714	Associated with various cellular activities
MRB58_04890	COG0471	metal ion transport
MRB58_04890	COG3273	potassium ion transport
MRB58_04910	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MRB58_04915	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_04925	COG1024	Enoyl-CoA hydratase
MRB58_04930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_04935	COG0154	amidase activity
MRB58_04940	COG3842	ATPase activity
MRB58_04950	COG1176	ABC-type spermidine putrescine transport system, permease component I
MRB58_04990	COG0714	Associated with various cellular activities
MRB58_04995	COG1522	sequence-specific DNA binding
MRB58_05015	COG2211	Major facilitator Superfamily
MRB58_05020	COG0156	8-amino-7-oxononanoate synthase activity
MRB58_05025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MRB58_05040	COG0745	RESPONSE REGULATOR receiver
MRB58_05065	COG3920	Histidine kinase
MRB58_05075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MRB58_05080	COG0459	protein refolding
MRB58_05085	COG2226	methyltransferase
MRB58_05095	COG0203	ribosomal protein L17
MRB58_05100	COG0202	RNA polymerase activity
MRB58_05105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MRB58_05110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MRB58_05115	COG0563	adenylate kinase activity
MRB58_05120	COG0201	protein transport
MRB58_05125	COG0200	Binds to the 23S rRNA
MRB58_05135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MRB58_05140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MRB58_05145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MRB58_05150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MRB58_05155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MRB58_05160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MRB58_05165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MRB58_05170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MRB58_05180	COG0255	Belongs to the universal ribosomal protein uL29 family
MRB58_05185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MRB58_05190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MRB58_05195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MRB58_05200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MRB58_05205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MRB58_05215	COG0088	Forms part of the polypeptide exit tunnel
MRB58_05220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MRB58_05225	COG0051	transcription antitermination factor activity, RNA binding
MRB58_05230	COG2003	Belongs to the UPF0758 family
MRB58_05235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MRB58_05240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MRB58_05250	COG0049	tRNA binding
MRB58_05255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MRB58_05290	COG0154	amidase activity
MRB58_05300	COG0747	negative chemotaxis
MRB58_05305	COG0601	transmembrane transport
MRB58_05310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_05315	COG0444	Belongs to the ABC transporter superfamily
MRB58_05320	COG4608	Belongs to the ABC transporter superfamily
MRB58_05325	COG1070	Carbohydrate kinase
MRB58_05330	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_05335	COG4213	ABC transporter substrate-binding protein
MRB58_05355	COG2819	hydrolase of the alpha beta superfamily
MRB58_05365	COG4607	ABC-type enterochelin transport system periplasmic component
MRB58_05370	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRB58_05375	COG4605	iron ion homeostasis
MRB58_05390	COG0456	acetyltransferase
MRB58_05390	COG0454	-acetyltransferase
MRB58_05405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_05410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_05420	COG2186	Transcriptional regulator
MRB58_05430	COG3572	ergothioneine biosynthetic process
MRB58_05440	COG1570	exodeoxyribonuclease VII activity
MRB58_05445	COG0741	lytic transglycosylase activity
MRB58_05445	COG0739	heme binding
MRB58_05445	COG1196	nuclear chromosome segregation
MRB58_05450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MRB58_05465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MRB58_05480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MRB58_05490	COG1968	undecaprenyl-diphosphatase activity
MRB58_05520	COG0583	DNA-binding transcription factor activity
MRB58_05530	COG4944	Protein of unknown function (DUF1109)
MRB58_05545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_05545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_05550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_05555	COG0387	Pfam Sodium calcium exchanger
MRB58_05560	COG0457	Tetratricopeptide repeat
MRB58_05570	COG0473	3-isopropylmalate dehydrogenase activity
MRB58_05580	COG0235	Class ii aldolase
MRB58_05585	COG3395	kinase activity
MRB58_05590	COG0667	Aldo Keto reductase
MRB58_05625	COG1802	Transcriptional regulator
MRB58_05630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MRB58_05635	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_05640	COG4172	Belongs to the ABC transporter superfamily
MRB58_05660	COG0583	DNA-binding transcription factor activity
MRB58_05680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_05685	COG2346	COG2346, Truncated hemoglobins
MRB58_05710	COG2201	protein-glutamate methylesterase activity
MRB58_05720	COG0643	Histidine kinase
MRB58_05720	COG0784	Response regulator, receiver
MRB58_05720	COG2198	Histidine kinase
MRB58_05755	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MRB58_05770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MRB58_05770	COG0574	Belongs to the PEP-utilizing enzyme family
MRB58_05780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MRB58_05790	COG0142	geranyltranstransferase activity
MRB58_05805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MRB58_05815	COG2897	thiosulfate sulfurtransferase activity
MRB58_05825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MRB58_05850	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_05895	COG0584	glycerophosphoryl diester phosphodiesterase
MRB58_05900	COG1349	DNA-binding transcription factor activity
MRB58_05905	COG3842	ATPase activity
MRB58_05920	COG0395	ABC-type sugar transport system, permease component
MRB58_05925	COG0469	pyruvate kinase activity
MRB58_05935	COG1566	PFAM secretion protein HlyD family protein
MRB58_05965	COG3616	Alanine racemase, N-terminal domain
MRB58_05970	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_05975	COG0747	negative chemotaxis
MRB58_05990	COG0444	Belongs to the ABC transporter superfamily
MRB58_06000	COG1802	Transcriptional regulator
MRB58_06010	COG3618	amidohydrolase
MRB58_06015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_06025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_06035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MRB58_06090	COG1175	transmembrane transport
MRB58_06095	COG0395	ABC-type sugar transport system, permease component
MRB58_06105	COG3842	ATPase activity
MRB58_06110	COG3842	ATPase activity
MRB58_06115	COG1461	Dihydroxyacetone kinase
MRB58_06140	COG2376	Dihydroxyacetone kinase
MRB58_06165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRB58_06175	COG2814	Major facilitator Superfamily
MRB58_06185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_06195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_06200	COG1802	Transcriptional regulator
MRB58_06210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MRB58_06215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MRB58_06255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MRB58_06260	COG3768	UPF0283 membrane protein
MRB58_06265	COG3106	COG3106 Predicted ATPase
MRB58_06280	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_06325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRB58_06370	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_06370	COG1388	LysM domain
MRB58_06395	COG4608	Belongs to the ABC transporter superfamily
MRB58_06410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_06415	COG0601	transmembrane transport
MRB58_06420	COG4166	transmembrane transport
MRB58_06445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MRB58_06450	COG0402	S-adenosylhomocysteine deaminase activity
MRB58_06460	COG2249	NAD(P)H dehydrogenase (quinone) activity
MRB58_06470	COG0697	spore germination
MRB58_06480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MRB58_06485	COG0527	aspartate kinase activity
MRB58_06495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MRB58_06500	COG2890	protein-(glutamine-N5) methyltransferase activity
MRB58_06520	COG0438	transferase activity, transferring glycosyl groups
MRB58_06540	COG2885	chlorophyll binding
MRB58_06545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MRB58_06565	COG2135	peptidase activity
MRB58_06580	COG0354	folic acid binding
MRB58_06585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MRB58_06615	COG0783	Belongs to the Dps family
MRB58_06625	COG3454	Phosphonate metabolism
MRB58_06630	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MRB58_06645	COG4778	phosphonate C-P lyase system protein PhnL
MRB58_06650	COG4107	phosphonate C-P lyase system protein PhnK
MRB58_06665	COG3627	carbon phosphorus lyase activity
MRB58_06675	COG3626	phosphonate metabolism
MRB58_06680	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
MRB58_06685	COG3624	Phosphonate C-P lyase system protein PhnG
MRB58_06690	COG0670	Belongs to the BI1 family
MRB58_06730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_06745	COG0402	S-adenosylhomocysteine deaminase activity
MRB58_06760	COG3845	ABC transporter
MRB58_06765	COG4603	Belongs to the binding-protein-dependent transport system permease family
MRB58_06770	COG1079	Belongs to the binding-protein-dependent transport system permease family
MRB58_06815	COG2186	Transcriptional regulator
MRB58_06820	COG2358	TRAP transporter, solute receptor (TAXI family
MRB58_06840	COG4251	negative regulation of phosphorylation
MRB58_06845	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MRB58_06865	COG0583	DNA-binding transcription factor activity
MRB58_06895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MRB58_06905	COG0228	four-way junction DNA binding
MRB58_06910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MRB58_06915	COG0336	Belongs to the RNA methyltransferase TrmD family
MRB58_06940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MRB58_06970	COG3750	Belongs to the UPF0335 family
MRB58_06980	COG0469	pyruvate kinase activity
MRB58_06990	COG1984	allophanate hydrolase subunit 2
MRB58_07000	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MRB58_07005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRB58_07010	COG2205	protein histidine kinase activity
MRB58_07020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MRB58_07030	COG1074	ATP-dependent DNA helicase activity
MRB58_07040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MRB58_07050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MRB58_07050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MRB58_07060	COG0314	molybdopterin synthase activity
MRB58_07070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MRB58_07080	COG4135	transport system, permease component
MRB58_07085	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MRB58_07100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MRB58_07105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MRB58_07115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRB58_07130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MRB58_07135	COG2323	membrane
MRB58_07140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MRB58_07145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MRB58_07150	COG0484	heat shock protein binding
MRB58_07155	COG0443	Heat shock 70 kDa protein
MRB58_07160	COG2353	YceI-like domain
MRB58_07165	COG2353	YceI-like domain
MRB58_07185	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MRB58_07205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MRB58_07215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MRB58_07220	COG0418	dihydroorotase activity
MRB58_07225	COG0167	dihydroorotate dehydrogenase activity
MRB58_07240	COG3920	Histidine kinase
MRB58_07260	COG1850	ribulose-bisphosphate carboxylase activity
MRB58_07270	COG3246	L-lysine catabolic process to acetate
MRB58_07280	COG1215	transferase activity, transferring glycosyl groups
MRB58_07295	COG0384	phenazine biosynthesis protein PhzF
MRB58_07310	COG0322	excinuclease ABC activity
MRB58_07320	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_07340	COG0737	Belongs to the 5'-nucleotidase family
MRB58_07345	COG0737	Belongs to the 5'-nucleotidase family
MRB58_07360	COG2967	ApaG domain
MRB58_07380	COG3119	arylsulfatase activity
MRB58_07400	COG4175	Glycine betaine
MRB58_07405	COG0513	Belongs to the DEAD box helicase family
MRB58_07410	COG1278	Cold shock
MRB58_07425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MRB58_07460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRB58_07475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MRB58_07485	COG0346	lactoylglutathione lyase activity
MRB58_07515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MRB58_07535	COG4974	Belongs to the 'phage' integrase family
MRB58_07570	COG1802	Transcriptional regulator
MRB58_07580	COG3307	-O-antigen
MRB58_07585	COG2273	Hydrolase Family 16
MRB58_07605	COG2244	polysaccharide biosynthetic process
MRB58_07630	COG0792	nuclease activity
MRB58_07640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MRB58_07655	COG1686	Belongs to the peptidase S11 family
MRB58_07660	COG0583	DNA-binding transcription factor activity
MRB58_07670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRB58_07700	COG2813	Specifically methylates the guanine in position
MRB58_07700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRB58_07705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRB58_07715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MRB58_07720	COG0287	Prephenate dehydrogenase
MRB58_07750	COG2884	Cell division ATP-binding protein ftsE
MRB58_07760	COG0019	diaminopimelate decarboxylase activity
MRB58_07770	COG0165	Argininosuccinate lyase
MRB58_07775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MRB58_07785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MRB58_07790	COG2373	Large extracellular alpha-helical protein
MRB58_07795	COG4953	penicillin-binding protein 1C
MRB58_07800	COG1280	lysine exporter protein (LysE YggA)
MRB58_07810	COG0640	Transcriptional regulator
MRB58_07820	COG3321	synthase
MRB58_07820	COG0604	alcohol dehydrogenase
MRB58_07820	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_07830	COG2917	probably involved in intracellular septation
MRB58_07835	COG1137	ATPase activity
MRB58_07840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MRB58_07845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MRB58_07850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRB58_07875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MRB58_07880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MRB58_07895	COG0183	Belongs to the thiolase family
MRB58_07920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRB58_07940	COG0584	glycerophosphoryl diester phosphodiesterase
MRB58_07950	COG0537	adenosine 5'-monophosphoramidase activity
MRB58_07970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MRB58_07980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MRB58_07990	COG1686	Belongs to the peptidase S11 family
MRB58_08005	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MRB58_08010	COG1176	ABC-type spermidine putrescine transport system, permease component I
MRB58_08020	COG3842	ATPase activity
MRB58_08035	COG0542	response to heat
MRB58_08045	COG0739	heme binding
MRB58_08090	COG1032	radical SAM domain protein
MRB58_08095	COG1764	response to oxidative stress
MRB58_08100	COG1053	succinate dehydrogenase
MRB58_08105	COG1335	isochorismatase
MRB58_08140	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_08145	COG0683	leucine binding
MRB58_08150	COG2188	Transcriptional regulator
MRB58_08155	COG1902	pentaerythritol trinitrate reductase activity
MRB58_08155	COG0446	pyridine nucleotide-disulphide oxidoreductase
MRB58_08160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRB58_08165	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_08170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MRB58_08175	COG0066	3-isopropylmalate dehydratase activity
MRB58_08180	COG0604	alcohol dehydrogenase
MRB58_08190	COG1840	ABC-type Fe3 transport system, periplasmic component
MRB58_08195	COG2911	Protein conserved in bacteria
MRB58_08200	COG0729	surface antigen
MRB58_08210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRB58_08230	COG0811	peptide transport
MRB58_08240	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_08245	COG0235	Class ii aldolase
MRB58_08250	COG4172	Belongs to the ABC transporter superfamily
MRB58_08255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_08260	COG0601	transmembrane transport
MRB58_08280	COG1640	4-alpha-glucanotransferase
MRB58_08285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MRB58_08305	COG0366	Alpha amylase catalytic
MRB58_08315	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_08320	COG3387	PFAM Glycoside hydrolase 15-related
MRB58_08325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRB58_08335	COG0505	Belongs to the CarA family
MRB58_08345	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_08355	COG2224	Isocitrate lyase
MRB58_08380	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_08380	COG0604	alcohol dehydrogenase
MRB58_08380	COG3321	synthase
MRB58_08400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_08410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_08415	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_08425	COG2255	four-way junction helicase activity
MRB58_08430	COG0632	four-way junction helicase activity
MRB58_08435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MRB58_08455	COG2771	luxR family
MRB58_08460	COG3916	Acyl-homoserine-lactone synthase
MRB58_08465	COG1692	metallophosphoesterase
MRB58_08475	COG0697	spore germination
MRB58_08495	COG0668	transmembrane transport
MRB58_08505	COG0174	glutamine synthetase
MRB58_08510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_08515	COG4221	oxidoreductase activity
MRB58_08525	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_08530	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_08535	COG1129	ABC transporter
MRB58_08540	COG1879	ABC-type sugar transport system periplasmic component
MRB58_08550	COG0129	dihydroxy-acid dehydratase activity
MRB58_08560	COG4214	carbohydrate transport
MRB58_08570	COG4213	ABC transporter substrate-binding protein
MRB58_08580	COG1069	ribulokinase activity
MRB58_08595	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_08615	COG0668	transmembrane transport
MRB58_08625	COG1215	transferase activity, transferring glycosyl groups
MRB58_08640	COG0438	transferase activity, transferring glycosyl groups
MRB58_08645	COG1215	transferase activity, transferring glycosyl groups
MRB58_08650	COG3206	protein involved in exopolysaccharide biosynthesis
MRB58_08650	COG0489	protein tyrosine kinase activity
MRB58_08665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MRB58_08670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MRB58_08675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MRB58_08685	COG0151	Belongs to the GarS family
MRB58_08705	COG0312	modulator of DNA gyrase
MRB58_08710	COG0483	inositol monophosphate 1-phosphatase activity
MRB58_08720	COG1519	Transferase
MRB58_08725	COG1663	tetraacyldisaccharide 4'-kinase activity
MRB58_08760	COG0747	negative chemotaxis
MRB58_08765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_08790	COG1024	Enoyl-CoA hydratase
MRB58_08795	COG1960	acyl-CoA dehydrogenase activity
MRB58_08810	COG0583	DNA-binding transcription factor activity
MRB58_08820	COG0346	lactoylglutathione lyase activity
MRB58_08840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_08845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MRB58_08865	COG0742	ribosomal rna small subunit methyltransferase
MRB58_08870	COG1187	pseudouridine synthase activity
MRB58_08875	COG0590	tRNA wobble adenosine to inosine editing
MRB58_08890	COG0481	GTPase activity
MRB58_08955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MRB58_08960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MRB58_08980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MRB58_08990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MRB58_09005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MRB58_09015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MRB58_09030	COG0697	spore germination
MRB58_09055	COG0534	Mate efflux family protein
MRB58_09060	COG2226	methyltransferase
MRB58_09065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MRB58_09075	COG1280	lysine exporter protein (LysE YggA)
MRB58_09085	COG1744	ABC transporter substrate-binding protein PnrA-like
MRB58_09090	COG3845	ABC transporter
MRB58_09095	COG1079	Belongs to the binding-protein-dependent transport system permease family
MRB58_09105	COG1079	Belongs to the binding-protein-dependent transport system permease family
MRB58_09110	COG2885	chlorophyll binding
MRB58_09120	COG0037	tRNA processing
MRB58_09125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRB58_09135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MRB58_09150	COG2301	Belongs to the HpcH HpaI aldolase family
MRB58_09160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRB58_09170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MRB58_09180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_09190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_09195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_09205	COG0402	S-adenosylhomocysteine deaminase activity
MRB58_09220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MRB58_09220	COG2169	Transcriptional regulator
MRB58_09240	COG1230	cation diffusion facilitator family transporter
MRB58_09250	COG1218	3'(2'),5'-bisphosphate nucleotidase
MRB58_09255	COG0175	sulfate reduction
MRB58_09290	COG1053	succinate dehydrogenase
MRB58_09295	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MRB58_09305	COG0312	modulator of DNA gyrase
MRB58_09315	COG0456	acetyltransferase
MRB58_09325	COG0235	Class ii aldolase
MRB58_09335	COG0433	COG0433 Predicted ATPase
MRB58_09350	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MRB58_09390	COG4175	Glycine betaine
MRB58_09390	COG3448	diguanylate cyclase activity
MRB58_09395	COG4176	ABC-type proline glycine betaine transport system permease component
MRB58_09425	COG0071	Belongs to the small heat shock protein (HSP20) family
MRB58_09440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MRB58_09450	COG0745	RESPONSE REGULATOR receiver
MRB58_09465	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
MRB58_09470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MRB58_09475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MRB58_09475	COG0475	glutathione-regulated potassium exporter activity
MRB58_09490	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_09495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MRB58_09515	COG0583	DNA-binding transcription factor activity
MRB58_09525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MRB58_09535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MRB58_09540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MRB58_09555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MRB58_09565	COG0072	phenylalanine-tRNA ligase activity
MRB58_09565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRB58_09575	COG2835	tetraacyldisaccharide 4'-kinase activity
MRB58_09580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MRB58_09585	COG3118	belongs to the thioredoxin family
MRB58_09610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MRB58_09615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MRB58_09625	COG0189	ligase activity
MRB58_09630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MRB58_09640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MRB58_09645	COG0756	dUTP diphosphatase activity
MRB58_09660	COG3064	Membrane
MRB58_09670	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_09685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_09690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MRB58_09710	COG0495	leucyl-tRNA aminoacylation
MRB58_09730	COG0789	Transcriptional regulator
MRB58_09765	COG0174	glutamine synthetase
MRB58_09785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MRB58_09800	COG4993	Dehydrogenase
MRB58_09805	COG0180	Tryptophanyl-tRNA synthetase
MRB58_09835	COG3030	protein affecting phage T7 exclusion by the F plasmid
MRB58_09840	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MRB58_09845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MRB58_09850	COG0237	dephospho-CoA kinase activity
MRB58_09855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MRB58_09860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MRB58_09865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MRB58_09870	COG1981	membrane
MRB58_09875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MRB58_09880	COG1331	Highly conserved protein containing a thioredoxin domain
MRB58_09885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MRB58_09890	COG0445	tRNA wobble uridine modification
MRB58_09895	COG0357	Ribosomal RNA small subunit methyltransferase G
MRB58_09915	COG0540	Belongs to the ATCase OTCase family
MRB58_09920	COG0123	including yeast histone deacetylase and acetoin utilization protein
MRB58_09935	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_09950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_09965	COG1653	transport
MRB58_09980	COG3842	ATPase activity
MRB58_09990	COG0601	transmembrane transport
MRB58_09995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_10010	COG0154	amidase activity
MRB58_10035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MRB58_10040	COG1201	RNA secondary structure unwinding
MRB58_10050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MRB58_10070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MRB58_10075	COG0697	spore germination
MRB58_10100	COG0667	Aldo Keto reductase
MRB58_10115	COG1072	(Pantothenic acid kinase))
MRB58_10120	COG0140	phosphoribosyl-ATP diphosphatase activity
MRB58_10125	COG0107	imidazoleglycerol-phosphate synthase activity
MRB58_10130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MRB58_10135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MRB58_10145	COG0131	Imidazoleglycerol-phosphate dehydratase
MRB58_10150	COG0284	orotidine-5'-phosphate decarboxylase activity
MRB58_10165	COG0728	peptidoglycan biosynthetic process
MRB58_10170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MRB58_10175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MRB58_10180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MRB58_10185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MRB58_10205	COG0436	Aminotransferase
MRB58_10235	COG4566	intracellular signal transduction
MRB58_10240	COG4566	intracellular signal transduction
MRB58_10245	COG4191	Histidine kinase
MRB58_10250	COG0583	DNA-binding transcription factor activity
MRB58_10260	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_10280	COG0500	methyltransferase
MRB58_10295	COG0628	permease
MRB58_10340	COG3800	Transcriptional regulator
MRB58_10340	COG1396	sequence-specific DNA binding
MRB58_10345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MRB58_10350	COG4770	biotin carboxylase activity
MRB58_10370	COG4177	L-phenylalanine transmembrane transporter activity
MRB58_10385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MRB58_10390	COG2186	Transcriptional regulator
MRB58_10430	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_10445	COG1960	acyl-CoA dehydrogenase activity
MRB58_10480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_10490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_10490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_10500	COG4221	oxidoreductase activity
MRB58_10510	COG0583	DNA-binding transcription factor activity
MRB58_10515	COG1850	ribulose-bisphosphate carboxylase activity
MRB58_10525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_10535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_10540	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MRB58_10545	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_10550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MRB58_10565	COG1733	regulation of RNA biosynthetic process
MRB58_10590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRB58_10630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRB58_10660	COG4566	intracellular signal transduction
MRB58_10665	COG4566	intracellular signal transduction
MRB58_10670	COG4566	intracellular signal transduction
MRB58_10675	COG4191	Histidine kinase
MRB58_10700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MRB58_10765	COG1061	Type III restriction enzyme res subunit
MRB58_10805	COG1475	DNA binding
MRB58_10850	COG0740	serine-type endopeptidase activity
MRB58_10875	COG3609	addiction module antidote protein, CC2985 family
MRB58_10940	COG1475	DNA binding
MRB58_10965	COG4191	Histidine kinase
MRB58_10970	COG4566	intracellular signal transduction
MRB58_10975	COG4566	intracellular signal transduction
MRB58_10990	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_10995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MRB58_11040	COG1733	regulation of RNA biosynthetic process
MRB58_11045	COG4977	sequence-specific DNA binding
MRB58_11065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRB58_11100	COG1012	belongs to the aldehyde dehydrogenase family
MRB58_11125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRB58_11150	COG2319	Wd-40 repeat
MRB58_11150	COG4249	Peptidase C14 caspase catalytic subunit p20
MRB58_11170	COG4249	Peptidase C14 caspase catalytic subunit p20
MRB58_11170	COG2319	Wd-40 repeat
MRB58_11425	COG2963	transposase activity
MRB58_11455	COG1132	(ABC) transporter
MRB58_11465	COG0110	maltose O-acetyltransferase activity
MRB58_11480	COG0438	transferase activity, transferring glycosyl groups
MRB58_11505	COG0438	transferase activity, transferring glycosyl groups
MRB58_11510	COG1215	transferase activity, transferring glycosyl groups
MRB58_11545	COG0463	Glycosyl transferase, family 2
MRB58_11660	COG2963	transposase activity
MRB58_11665	COG3436	PFAM IS66 Orf2 family protein
MRB58_11670	COG4372	Transposase
MRB58_11695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MRB58_11715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MRB58_11725	COG0347	Belongs to the P(II) protein family
MRB58_11730	COG0004	ammonium transporteR
MRB58_11740	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_11765	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_11775	COG0076	glutamate decarboxylase activity
MRB58_11785	COG0387	Pfam Sodium calcium exchanger
MRB58_11810	COG3634	alkyl hydroperoxide reductase activity
MRB58_11820	COG0668	transmembrane transport
MRB58_11860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MRB58_11860	COG2010	Cytochrome c
MRB58_11865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MRB58_11880	COG4191	Histidine kinase
MRB58_11885	COG1802	Transcriptional regulator
MRB58_11895	COG4177	L-phenylalanine transmembrane transporter activity
MRB58_11915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRB58_11925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MRB58_11955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MRB58_11975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_11975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_11985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_11990	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_11995	COG0583	DNA-binding transcription factor activity
MRB58_12000	COG0583	DNA-binding transcription factor activity
MRB58_12010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRB58_12015	COG0583	DNA-binding transcription factor activity
MRB58_12020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_12030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_12035	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_12040	COG3958	Transketolase
MRB58_12045	COG3959	Transketolase, thiamine diphosphate binding domain
MRB58_12070	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_12075	COG1177	transmembrane transport
MRB58_12080	COG1176	ABC-type spermidine putrescine transport system, permease component I
MRB58_12085	COG3842	ATPase activity
MRB58_12090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MRB58_12095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_12105	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_12140	COG2030	dehydratase
MRB58_12145	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_12165	COG1024	Enoyl-CoA hydratase
MRB58_12195	COG1960	acyl-CoA dehydrogenase activity
MRB58_12205	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MRB58_12210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_12215	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_12245	COG1959	2 iron, 2 sulfur cluster binding
MRB58_12250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MRB58_12260	COG4208	sulfate ABC transporter
MRB58_12265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MRB58_12285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_12295	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_12305	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_12335	COG1335	isochorismatase
MRB58_12350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_12355	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
MRB58_12370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MRB58_12370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRB58_12385	COG1120	ATPase activity
MRB58_12390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRB58_12395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRB58_12415	COG0668	transmembrane transport
MRB58_12425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_12425	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MRB58_12430	COG3842	ATPase activity
MRB58_12445	COG0395	ABC-type sugar transport system, permease component
MRB58_12485	COG2205	protein histidine kinase activity
MRB58_12495	COG0306	phosphate transporter
MRB58_12515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MRB58_12515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MRB58_12520	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_12595	COG1228	amidohydrolase
MRB58_12600	COG1177	transmembrane transport
MRB58_12605	COG3842	ATPase activity
MRB58_12615	COG1176	ABC-type spermidine putrescine transport system, permease component I
MRB58_12635	COG3608	succinylglutamate desuccinylase aspartoacylase
MRB58_12640	COG0006	proline dipeptidase activity
MRB58_12645	COG2423	ornithine cyclodeaminase activity
MRB58_12650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MRB58_12660	COG0589	response to stress
MRB58_12665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_12670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_12675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_12680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MRB58_12685	COG1522	sequence-specific DNA binding
MRB58_12695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRB58_12710	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MRB58_12730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MRB58_12735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MRB58_12750	COG4178	(ABC) transporter
MRB58_12755	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_12760	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_12765	COG1129	ABC transporter
MRB58_12785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MRB58_12790	COG5002	protein histidine kinase activity
MRB58_12800	COG0573	inorganic phosphate transmembrane transporter activity
MRB58_12810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MRB58_12815	COG0704	Plays a role in the regulation of phosphate uptake
MRB58_12820	COG0745	RESPONSE REGULATOR receiver
MRB58_12830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MRB58_12835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MRB58_12845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MRB58_12870	COG0784	Response regulator, receiver
MRB58_12885	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_12890	COG0411	ABC transporter
MRB58_12915	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MRB58_12940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MRB58_12945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MRB58_12985	COG0598	Magnesium transport protein CorA
MRB58_12990	COG0137	argininosuccinate synthase activity
MRB58_12995	COG4783	chaperone-mediated protein folding
MRB58_13005	COG1250	3-hydroxyacyl-CoA dehydrogenase
MRB58_13010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MRB58_13015	COG2086	electron transfer activity
MRB58_13030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MRB58_13035	COG1946	Acyl-CoA thioesterase
MRB58_13040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MRB58_13045	COG0181	hydroxymethylbilane synthase activity
MRB58_13060	COG2816	NAD+ diphosphatase activity
MRB58_13070	COG3474	cytochrome
MRB58_13080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MRB58_13090	COG3387	PFAM Glycoside hydrolase 15-related
MRB58_13095	COG1877	trehalose-phosphatase activity
MRB58_13105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MRB58_13110	COG4134	Bacterial extracellular solute-binding protein
MRB58_13115	COG4232	protein-disulfide reductase activity
MRB58_13125	COG4166	transmembrane transport
MRB58_13130	COG4166	transmembrane transport
MRB58_13135	COG4174	ABC transporter (Permease)
MRB58_13140	COG4239	(ABC) transporter, permease
MRB58_13150	COG4172	Belongs to the ABC transporter superfamily
MRB58_13160	COG0196	riboflavin kinase activity
MRB58_13170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MRB58_13175	COG0824	Thioesterase
MRB58_13195	COG0823	Involved in the tonB-independent uptake of proteins
MRB58_13220	COG0109	protoheme IX farnesyltransferase activity
MRB58_13225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MRB58_13230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MRB58_13250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MRB58_13260	COG0583	DNA-binding transcription factor activity
MRB58_13265	COG0667	Aldo Keto reductase
MRB58_13295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MRB58_13305	COG0300	oxidoreductase activity
MRB58_13310	COG0300	oxidoreductase activity
MRB58_13330	COG1793	dna ligase
MRB58_13345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MRB58_13370	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MRB58_13380	COG2721	sulfolactate sulfo-lyase activity
MRB58_13415	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_13420	COG2200	EAL domain
MRB58_13425	COG0179	Fumarylacetoacetate (FAA) hydrolase
MRB58_13430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRB58_13440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MRB58_13460	COG0671	phosphoesterase, PA-phosphatase related
MRB58_13470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MRB58_13475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MRB58_13475	COG3608	succinylglutamate desuccinylase aspartoacylase
MRB58_13495	COG0745	RESPONSE REGULATOR receiver
MRB58_13500	COG0642	Histidine kinase
MRB58_13505	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MRB58_13510	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MRB58_13510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MRB58_13525	COG5001	Diguanylate cyclase
MRB58_13530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MRB58_13540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MRB58_13545	COG5328	Belongs to the UPF0262 family
MRB58_13555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MRB58_13560	COG0424	maF-like protein
MRB58_13565	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MRB58_13575	COG1366	Belongs to the anti-sigma-factor antagonist family
MRB58_13610	COG2208	phosphoserine phosphatase activity
MRB58_13610	COG2770	Histidine kinase
MRB58_13620	COG0210	DNA helicase
MRB58_13645	COG1349	DNA-binding transcription factor activity
MRB58_13670	COG1454	alcohol dehydrogenase
MRB58_13695	COG0277	FAD linked oxidase domain protein
MRB58_13700	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
MRB58_13705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MRB58_13735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MRB58_13740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MRB58_13755	COG0697	spore germination
MRB58_13760	COG3622	Belongs to the hyi family
MRB58_13770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MRB58_13785	COG1741	Belongs to the pirin family
MRB58_13790	COG0659	secondary active sulfate transmembrane transporter activity
MRB58_13795	COG0589	response to stress
MRB58_13800	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_13800	COG1388	LysM domain
MRB58_13810	COG2116	formate transmembrane transporter activity
MRB58_13815	COG3920	Histidine kinase
MRB58_13820	COG0405	Gamma-glutamyltransferase
MRB58_13835	COG0457	Tetratricopeptide repeat
MRB58_13840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MRB58_13850	COG2894	cell division
MRB58_13855	COG0850	regulation of cytokinetic process
MRB58_13870	COG0431	NADPH-dependent FMN reductase
MRB58_13875	COG0798	PFAM Bile acid sodium symporter
MRB58_13880	COG1393	Belongs to the ArsC family
MRB58_13905	COG2188	Transcriptional regulator
MRB58_13910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_13920	COG2030	dehydratase
MRB58_13925	COG1960	acyl-CoA dehydrogenase activity
MRB58_13930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_13945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_13950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MRB58_13955	COG0583	DNA-binding transcription factor activity
MRB58_13960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_13975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_13975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_13985	COG1937	Protein conserved in bacteria
MRB58_13995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRB58_14000	COG0583	DNA-binding transcription factor activity
MRB58_14015	COG0604	alcohol dehydrogenase
MRB58_14015	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_14015	COG3321	synthase
MRB58_14025	COG1177	transmembrane transport
MRB58_14030	COG4149	molybdate abc transporter
MRB58_14040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MRB58_14045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MRB58_14055	COG0667	Aldo Keto reductase
MRB58_14060	COG0583	DNA-binding transcription factor activity
MRB58_14075	COG0577	efflux transmembrane transporter activity
MRB58_14075	COG1136	(ABC) transporter
MRB58_14095	COG0523	cobalamin synthesis protein
MRB58_14100	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MRB58_14105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MRB58_14115	COG4206	TonB-dependent receptor
MRB58_14120	COG0246	Mannitol dehydrogenase
MRB58_14125	COG1312	Catalyzes the dehydration of D-mannonate
MRB58_14130	COG1802	Transcriptional regulator
MRB58_14135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_14145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_14150	COG1063	alcohol dehydrogenase
MRB58_14155	COG3191	aminopeptidase activity
MRB58_14160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MRB58_14165	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_14170	COG2130	NADP-dependent
MRB58_14175	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_14215	COG1960	acyl-CoA dehydrogenase activity
MRB58_14220	COG1960	acyl-CoA dehydrogenase activity
MRB58_14225	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_14230	COG0183	Belongs to the thiolase family
MRB58_14235	COG1960	acyl-CoA dehydrogenase activity
MRB58_14260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MRB58_14265	COG1960	acyl-CoA dehydrogenase activity
MRB58_14270	COG1960	acyl-CoA dehydrogenase activity
MRB58_14275	COG1024	Enoyl-CoA hydratase
MRB58_14275	COG1250	3-hydroxyacyl-CoA dehydrogenase
MRB58_14295	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MRB58_14300	COG0277	FAD linked oxidase domain protein
MRB58_14305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MRB58_14315	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MRB58_14320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MRB58_14330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRB58_14330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MRB58_14340	COG1832	CoA-binding protein
MRB58_14350	COG0625	glutathione transferase activity
MRB58_14355	COG1024	Enoyl-CoA hydratase
MRB58_14365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MRB58_14380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MRB58_14390	COG3243	poly(R)-hydroxyalkanoic acid synthase
MRB58_14400	COG0436	Aminotransferase
MRB58_14430	COG0154	amidase activity
MRB58_14435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MRB58_14455	COG0525	valine-tRNA ligase activity
MRB58_14465	COG4765	Protein conserved in bacteria
MRB58_14470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MRB58_14480	COG0511	ligase activity, forming carbon-carbon bonds
MRB58_14490	COG1530	ribonuclease E activity
MRB58_14490	COG1530	ribonuclease E activity
MRB58_14495	COG0860	N-Acetylmuramoyl-L-alanine amidase
MRB58_14500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MRB58_14510	COG0778	Nitroreductase
MRB58_14530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MRB58_14545	COG2321	neutral zinc metallopeptidase
MRB58_14550	COG0358	DNA primase activity
MRB58_14555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MRB58_14575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MRB58_14580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MRB58_14585	COG2080	2 iron, 2 sulfur cluster binding
MRB58_14600	COG3246	L-lysine catabolic process to acetate
MRB58_14605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MRB58_14615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_14625	COG4608	Belongs to the ABC transporter superfamily
MRB58_14630	COG0444	Belongs to the ABC transporter superfamily
MRB58_14635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_14640	COG0601	transmembrane transport
MRB58_14645	COG1735	metal-dependent hydrolase with the TIM-barrel fold
MRB58_14655	COG0747	negative chemotaxis
MRB58_14660	COG1802	Transcriptional regulator
MRB58_14670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MRB58_14675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MRB58_14680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_14690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MRB58_14700	COG0765	amino acid transport
MRB58_14705	COG4598	ABC transporter
MRB58_14710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MRB58_14715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MRB58_14720	COG2986	histidine ammonia-lyase
MRB58_14725	COG1228	amidohydrolase
MRB58_14750	COG5001	Diguanylate cyclase
MRB58_14765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_14770	COG0601	transmembrane transport
MRB58_14780	COG0583	DNA-binding transcription factor activity
MRB58_14810	COG1960	acyl-CoA dehydrogenase activity
MRB58_14825	COG1960	acyl-CoA dehydrogenase activity
MRB58_14840	COG0596	Alpha beta hydrolase
MRB58_14845	COG0633	Ferredoxin
MRB58_14855	COG1079	Belongs to the binding-protein-dependent transport system permease family
MRB58_14860	COG4603	Belongs to the binding-protein-dependent transport system permease family
MRB58_14865	COG3845	ABC transporter
MRB58_14875	COG2358	TRAP transporter, solute receptor (TAXI family
MRB58_14895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_14900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_14905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_14915	COG0514	ATP-dependent DNA helicase (RecQ)
MRB58_14925	COG0717	Belongs to the dCTP deaminase family
MRB58_14945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MRB58_14960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MRB58_14990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MRB58_14995	COG1137	ATPase activity
MRB58_15020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRB58_15025	COG0420	3'-5' exonuclease activity
MRB58_15040	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MRB58_15050	COG1691	(AIR) carboxylase
MRB58_15055	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MRB58_15070	COG0408	coproporphyrinogen oxidase activity
MRB58_15075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MRB58_15090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MRB58_15090	COG2857	Cytochrome c1
MRB58_15095	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MRB58_15095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MRB58_15105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRB58_15115	COG2171	N-acyltransferase activity
MRB58_15125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MRB58_15140	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_15150	COG2721	sulfolactate sulfo-lyase activity
MRB58_15160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MRB58_15170	COG0583	DNA-binding transcription factor activity
MRB58_15185	COG1802	Transcriptional regulator
MRB58_15190	COG1902	pentaerythritol trinitrate reductase activity
MRB58_15195	COG1764	response to oxidative stress
MRB58_15200	COG0693	protein deglycase activity
MRB58_15210	COG2308	Evidence 4 Homologs of previously reported genes of
MRB58_15210	COG2307	Protein conserved in bacteria
MRB58_15225	COG1733	regulation of RNA biosynthetic process
MRB58_15235	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MRB58_15240	COG0494	nUDIX hydrolase
MRB58_15245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MRB58_15250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MRB58_15255	COG0653	protein targeting
MRB58_15275	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_15290	COG1024	Enoyl-CoA hydratase
MRB58_15310	COG1960	acyl-CoA dehydrogenase activity
MRB58_15330	COG2366	antibiotic biosynthetic process
MRB58_15340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MRB58_15345	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
MRB58_15360	COG1121	(ABC) transporter
MRB58_15375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MRB58_15375	COG1116	anion transmembrane transporter activity
MRB58_15380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MRB58_15390	COG1116	anion transmembrane transporter activity
MRB58_15400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MRB58_15405	COG2146	nitrite reductase [NAD(P)H] activity
MRB58_15410	COG0243	molybdopterin cofactor binding
MRB58_15415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MRB58_15415	COG1648	precorrin-2 dehydrogenase activity
MRB58_15425	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_15440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_15445	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_15450	COG0583	DNA-binding transcription factor activity
MRB58_15455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MRB58_15460	COG0489	protein tyrosine kinase activity
MRB58_15465	COG2814	Major facilitator Superfamily
MRB58_15470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MRB58_15490	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_15495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MRB58_15500	COG0303	'Molybdopterin
MRB58_15505	COG0315	cyclic pyranopterin monophosphate synthase activity
MRB58_15515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MRB58_15525	COG0149	triose-phosphate isomerase activity
MRB58_15550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MRB58_15560	COG0753	catalase activity
MRB58_15565	COG0617	tRNA 3'-terminal CCA addition
MRB58_15565	COG0517	IMP dehydrogenase activity
MRB58_15565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MRB58_15590	COG3181	Tripartite tricarboxylate transporter family receptor
MRB58_15605	COG3246	L-lysine catabolic process to acetate
MRB58_15610	COG1250	3-hydroxyacyl-CoA dehydrogenase
MRB58_15615	COG1802	Transcriptional regulator
MRB58_15620	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_15640	COG0803	Belongs to the bacterial solute-binding protein 9 family
MRB58_15645	COG1121	(ABC) transporter
MRB58_15650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MRB58_15655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MRB58_15660	COG2954	triphosphatase activity
MRB58_15665	COG0010	Belongs to the arginase family
MRB58_15670	COG0840	transmembrane signaling receptor activity
MRB58_15685	COG0405	Gamma-glutamyltransferase
MRB58_15690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MRB58_15700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_15720	COG5001	Diguanylate cyclase
MRB58_15720	COG3300	MHYT domain
MRB58_15740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_15760	COG1024	Enoyl-CoA hydratase
MRB58_15765	COG2079	MmgE PrpD family protein
MRB58_15770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_15815	COG0725	ABC transporter, periplasmic molybdate-binding protein
MRB58_15830	COG1999	signal sequence binding
MRB58_15845	COG2226	methyltransferase
MRB58_15860	COG1612	heme a metabolic process
MRB58_15895	COG0009	L-threonylcarbamoyladenylate synthase
MRB58_15900	COG1960	acyl-CoA dehydrogenase activity
MRB58_15905	COG0799	negative regulation of ribosome biogenesis
MRB58_15910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MRB58_15920	COG0793	Belongs to the peptidase S41A family
MRB58_15940	COG1129	ABC transporter
MRB58_15960	COG1396	sequence-specific DNA binding
MRB58_15960	COG3800	Transcriptional regulator
MRB58_15965	COG0745	RESPONSE REGULATOR receiver
MRB58_15975	COG2205	protein histidine kinase activity
MRB58_15980	COG1160	GTP binding
MRB58_15985	COG0840	transmembrane signaling receptor activity
MRB58_16020	COG0745	RESPONSE REGULATOR receiver
MRB58_16025	COG1846	Transcriptional regulator
MRB58_16045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MRB58_16050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MRB58_16065	COG0612	Peptidase, M16
MRB58_16070	COG0612	Peptidase, M16
MRB58_16080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MRB58_16085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MRB58_16095	COG0678	peroxiredoxin activity
MRB58_16095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MRB58_16100	COG1678	Uncharacterized ACR, COG1678
MRB58_16110	COG0612	Peptidase, M16
MRB58_16115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MRB58_16125	COG0028	Belongs to the TPP enzyme family
MRB58_16140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MRB58_16145	COG0438	transferase activity, transferring glycosyl groups
MRB58_16160	COG1132	(ABC) transporter
MRB58_16165	COG3830	Belongs to the UPF0237 family
MRB58_16165	COG0560	Phosphoserine phosphatase
MRB58_16170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MRB58_16175	COG0028	Belongs to the TPP enzyme family
MRB58_16180	COG1872	DUF167
MRB58_16190	COG0440	acetolactate synthase activity
MRB58_16195	COG2818	Glycosylase
MRB58_16230	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MRB58_16235	COG0735	belongs to the Fur family
MRB58_16240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MRB58_16250	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MRB58_16255	COG0135	phosphoribosylanthranilate isomerase activity
MRB58_16270	COG0133	tryptophan synthase activity
MRB58_16285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MRB58_16290	COG0285	dihydrofolate synthase activity
MRB58_16295	COG0616	signal peptide processing
MRB58_16310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MRB58_16320	COG0508	dehydrogenase complex catalyzes the overall conversion of
MRB58_16325	COG0567	Dehydrogenase, E1 component
MRB58_16335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MRB58_16360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MRB58_16380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MRB58_16390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MRB58_16395	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MRB58_16400	COG4133	protoheme IX ABC transporter activity
MRB58_16405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MRB58_16445	COG0045	succinate-CoA ligase (ADP-forming) activity
MRB58_16460	COG0039	L-malate dehydrogenase activity
MRB58_16465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MRB58_16470	COG1024	Enoyl-CoA hydratase
MRB58_16475	COG0268	Binds directly to 16S ribosomal RNA
MRB58_16495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MRB58_16510	COG0564	pseudouridine synthase activity
MRB58_16520	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_16525	COG1960	acyl-CoA dehydrogenase activity
MRB58_16540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MRB58_16540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MRB58_16545	COG1132	(ABC) transporter
MRB58_16560	COG0438	transferase activity, transferring glycosyl groups
MRB58_16560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MRB58_16565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MRB58_16575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MRB58_16580	COG0012	GTP binding
MRB58_16590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MRB58_16595	COG3852	Histidine kinase
MRB58_16605	COG0398	Pfam SNARE associated Golgi protein
MRB58_16615	COG0594	ribonuclease P activity
MRB58_16620	COG0706	membrane insertase activity
MRB58_16625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MRB58_16650	COG1136	(ABC) transporter
MRB58_16665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MRB58_16675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MRB58_16700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MRB58_16710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MRB58_16715	COG1802	Transcriptional regulator
MRB58_16720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_16730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_16735	COG3119	arylsulfatase activity
MRB58_16740	COG2326	polyphosphate kinase activity
MRB58_16745	COG0714	Associated with various cellular activities
MRB58_16785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MRB58_16835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRB58_16860	COG3181	Tripartite tricarboxylate transporter family receptor
MRB58_16870	COG0583	DNA-binding transcription factor activity
MRB58_16875	COG2186	Transcriptional regulator
MRB58_16895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MRB58_16905	COG3239	Fatty acid desaturase
MRB58_16920	COG1278	Cold shock
MRB58_16935	COG2388	GCN5-related N-acetyl-transferase
MRB58_16940	COG1741	Belongs to the pirin family
MRB58_16950	COG0583	DNA-binding transcription factor activity
MRB58_16985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MRB58_16990	COG0539	negative regulation of cytoplasmic translation
MRB58_17010	COG4149	molybdate abc transporter
MRB58_17015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MRB58_17025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MRB58_17025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MRB58_17030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MRB58_17035	COG0456	acetyltransferase
MRB58_17075	COG3443	Belongs to the bacterial solute-binding protein 9 family
MRB58_17085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MRB58_17090	COG0758	DNA mediated transformation
MRB58_17090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MRB58_17115	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MRB58_17120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MRB58_17125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MRB58_17135	COG1671	Belongs to the UPF0178 family
MRB58_17145	COG1278	Cold shock
MRB58_17150	COG0010	Belongs to the arginase family
MRB58_17155	COG1797	cobyrinic acid a,c-diamide synthase activity
MRB58_17165	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MRB58_17180	COG1228	amidohydrolase
MRB58_17185	COG1937	Protein conserved in bacteria
MRB58_17190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MRB58_17195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MRB58_17200	COG0829	nickel cation binding
MRB58_17205	COG0831	urea catabolic process
MRB58_17210	COG3813	Protein conserved in bacteria
MRB58_17215	COG0832	Belongs to the urease beta subunit family
MRB58_17220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MRB58_17225	COG1674	ftsk spoiiie
MRB58_17240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MRB58_17250	COG0326	Molecular chaperone. Has ATPase activity
MRB58_17290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MRB58_17295	COG1702	phosphate starvation-inducible protein PhoH
MRB58_17300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MRB58_17305	COG1253	flavin adenine dinucleotide binding
MRB58_17310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MRB58_17315	COG1396	sequence-specific DNA binding
MRB58_17320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MRB58_17325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MRB58_17335	COG0281	malic enzyme
MRB58_17335	COG0280	phosphate acetyltransferase
MRB58_17345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MRB58_17355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MRB58_17365	COG1929	Belongs to the glycerate kinase type-1 family
MRB58_17395	COG2001	Belongs to the MraZ family
MRB58_17400	COG0275	rRNA processing
MRB58_17415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MRB58_17425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MRB58_17430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MRB58_17440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MRB58_17445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MRB58_17450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MRB58_17455	COG1181	Belongs to the D-alanine--D-alanine ligase family
MRB58_17460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MRB58_17465	COG0849	cell division
MRB58_17470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MRB58_17470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MRB58_17475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MRB58_17480	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MRB58_17485	COG0497	DNA recombination
MRB58_17490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MRB58_17505	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_17535	COG2226	methyltransferase
MRB58_17540	COG0482	sulfurtransferase activity
MRB58_17555	COG0494	nUDIX hydrolase
MRB58_17560	COG4536	flavin adenine dinucleotide binding
MRB58_17565	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MRB58_17570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MRB58_17580	COG0825	malonyl-CoA metabolic process
MRB58_17585	COG3034	peptidoglycan biosynthetic process
MRB58_17600	COG0589	response to stress
MRB58_17610	COG1177	transmembrane transport
MRB58_17615	COG1176	ABC-type spermidine putrescine transport system, permease component I
MRB58_17630	COG0546	phosphoglycolate phosphatase activity
MRB58_17650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MRB58_17655	COG2814	Major facilitator Superfamily
MRB58_17660	COG0789	Transcriptional regulator
MRB58_17670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MRB58_17695	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_17705	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_17720	COG0508	dehydrogenase complex catalyzes the overall conversion of
MRB58_17730	COG1254	Belongs to the acylphosphatase family
MRB58_17735	COG4770	biotin carboxylase activity
MRB58_17745	COG1346	cytolysis
MRB58_17755	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_17765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MRB58_17775	COG0546	phosphoglycolate phosphatase activity
MRB58_17780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MRB58_17795	COG1573	uracil-dna glycosylase
MRB58_17805	COG1758	RNA polymerase activity
MRB58_17820	COG0736	holo-[acyl-carrier-protein] synthase activity
MRB58_17825	COG0681	Belongs to the peptidase S26 family
MRB58_17830	COG0571	ribonuclease III activity
MRB58_17835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MRB58_17840	COG1381	Involved in DNA repair and RecF pathway recombination
MRB58_17850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MRB58_17855	COG0556	nucleotide-excision repair
MRB58_17870	COG0583	DNA-binding transcription factor activity
MRB58_17875	COG0492	ferredoxin-NADP+ reductase activity
MRB58_17885	COG1522	sequence-specific DNA binding
MRB58_17920	COG0247	lactate metabolic process
MRB58_17930	COG0277	FAD linked oxidase domain protein
MRB58_17940	COG0277	FAD linked oxidase domain protein
MRB58_17945	COG0500	methyltransferase
MRB58_17950	COG2814	Major facilitator Superfamily
MRB58_17955	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MRB58_17985	COG0416	fatty acid biosynthetic process
MRB58_17990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MRB58_17995	COG0776	regulation of translation
MRB58_18030	COG0066	3-isopropylmalate dehydratase activity
MRB58_18045	COG2902	Dehydrogenase
MRB58_18055	COG1196	nuclear chromosome segregation
MRB58_18070	COG1194	a g-specific adenine glycosylase
MRB58_18075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MRB58_18080	COG1280	lysine exporter protein (LysE YggA)
MRB58_18115	COG0667	Aldo Keto reductase
MRB58_18130	COG0126	phosphoglycerate kinase activity
MRB58_18135	COG3588	fructose-bisphosphate aldolase
MRB58_18150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MRB58_18160	COG0483	inositol monophosphate 1-phosphatase activity
MRB58_18180	COG1132	(ABC) transporter
MRB58_18185	COG0254	rRNA binding
MRB58_18195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MRB58_18200	COG1473	amidohydrolase
MRB58_18215	COG0778	Nitroreductase
MRB58_18250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MRB58_18260	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MRB58_18270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MRB58_18280	COG1960	acyl-CoA dehydrogenase activity
MRB58_18295	COG2223	nitrite transmembrane transporter activity
MRB58_18300	COG3964	amidohydrolase
MRB58_18310	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_18320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_18325	COG1024	Enoyl-CoA hydratase
MRB58_18330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_18330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_18340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_18345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MRB58_18350	COG0277	FAD linked oxidase domain protein
MRB58_18350	COG0247	lactate metabolic process
MRB58_18355	COG1802	Transcriptional regulator
MRB58_18375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MRB58_18380	COG3273	potassium ion transport
MRB58_18380	COG0471	metal ion transport
MRB58_18385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MRB58_18390	COG0113	porphobilinogen synthase activity
MRB58_18400	COG1024	Enoyl-CoA hydratase
MRB58_18410	COG1846	Transcriptional regulator
MRB58_18415	COG2989	Protein conserved in bacteria
MRB58_18420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MRB58_18425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MRB58_18435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MRB58_18435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MRB58_18445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MRB58_18450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MRB58_18455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRB58_18460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MRB58_18535	COG1024	Enoyl-CoA hydratase
MRB58_18540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_18545	COG0367	asparagine synthase
MRB58_18555	COG1363	Peptidase, m42
MRB58_18560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MRB58_18565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MRB58_18585	COG2983	Belongs to the UPF0260 family
MRB58_18600	COG4695	Portal protein
MRB58_18695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MRB58_18700	COG2301	Belongs to the HpcH HpaI aldolase family
MRB58_18715	COG0583	DNA-binding transcription factor activity
MRB58_18740	COG0745	RESPONSE REGULATOR receiver
MRB58_18750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MRB58_18765	COG1496	oxidoreductase activity
MRB58_18775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MRB58_18800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MRB58_18805	COG1335	isochorismatase
MRB58_18810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MRB58_18820	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_18825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MRB58_18840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MRB58_18850	COG0305	Participates in initiation and elongation during chromosome replication
MRB58_18860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MRB58_18865	COG0359	binds to the 23S rRNA
MRB58_18875	COG0360	Binds together with S18 to 16S ribosomal RNA
MRB58_18880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MRB58_18895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MRB58_18900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MRB58_18905	COG1561	YicC-like family, N-terminal region
MRB58_18910	COG0194	GDP metabolic process
MRB58_18920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MRB58_18925	COG2218	PFAM glutamate synthase alpha subunit domain protein
MRB58_18930	COG0069	glutamate synthase activity
MRB58_18940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_18945	COG0154	amidase activity
MRB58_18950	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MRB58_18965	COG0683	leucine binding
MRB58_18970	COG1309	transcriptional regulator
MRB58_18980	COG2368	4-hydroxyphenylacetate
MRB58_19040	COG2080	2 iron, 2 sulfur cluster binding
MRB58_19045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MRB58_19050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MRB58_19055	COG4166	transmembrane transport
MRB58_19060	COG2329	Antibiotic biosynthesis monooxygenase
MRB58_19070	COG4771	TonB-dependent receptor
MRB58_19100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MRB58_19110	COG0629	single-stranded DNA binding
MRB58_19120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MRB58_19135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MRB58_19150	COG0343	queuine tRNA-ribosyltransferase activity
MRB58_19155	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_19160	COG0148	phosphopyruvate hydratase activity
MRB58_19170	COG1216	Glycosyl transferase, family 2
MRB58_19170	COG0438	transferase activity, transferring glycosyl groups
MRB58_19180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MRB58_19195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MRB58_19200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MRB58_19205	COG0402	S-adenosylhomocysteine deaminase activity
MRB58_19225	COG1217	gtp-binding protein TYPA
MRB58_19230	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MRB58_19235	COG0583	DNA-binding transcription factor activity
MRB58_19240	COG1335	isochorismatase
MRB58_19250	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_19255	COG1116	anion transmembrane transporter activity
MRB58_19265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_19270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MRB58_19275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_19300	COG0552	protein localization to endoplasmic reticulum
MRB58_19305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MRB58_19315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MRB58_19330	COG1238	metal cluster binding
MRB58_19335	COG0435	Glutathione S-transferase
MRB58_19345	COG2813	Specifically methylates the guanine in position
MRB58_19350	COG5310	Homospermidine synthase
MRB58_19375	COG2308	Evidence 4 Homologs of previously reported genes of
MRB58_19380	COG0861	Integral membrane protein TerC family
MRB58_19400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MRB58_19415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MRB58_19435	COG1960	acyl-CoA dehydrogenase activity
MRB58_19440	COG1024	Enoyl-CoA hydratase
MRB58_19470	COG1129	ABC transporter
MRB58_19495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_19525	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_19525	COG0604	alcohol dehydrogenase
MRB58_19525	COG3321	synthase
MRB58_19530	COG0156	8-amino-7-oxononanoate synthase activity
MRB58_19540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MRB58_19550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MRB58_19555	COG0741	lytic transglycosylase activity
MRB58_19560	COG2945	thiolester hydrolase activity
MRB58_19560	COG0596	Alpha beta hydrolase
MRB58_19565	COG3920	Histidine kinase
MRB58_19570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MRB58_19590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MRB58_19600	COG1070	Carbohydrate kinase
MRB58_19615	COG1136	(ABC) transporter
MRB58_19625	COG0442	prolyl-tRNA aminoacylation
MRB58_19645	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_19650	COG1879	ABC-type sugar transport system periplasmic component
MRB58_19655	COG3842	ATPase activity
MRB58_19675	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MRB58_19680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_19695	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MRB58_19700	COG0179	Fumarylacetoacetate (FAA) hydrolase
MRB58_19710	COG2267	carboxylic ester hydrolase activity
MRB58_19715	COG3781	membrane
MRB58_19720	COG0288	reversible hydration of carbon dioxide
MRB58_19745	COG2010	Cytochrome c
MRB58_19785	COG2363	Small membrane protein
MRB58_19790	COG1396	sequence-specific DNA binding
MRB58_19795	COG0114	fumarate hydratase activity
MRB58_19815	COG0277	FAD linked oxidase domain protein
MRB58_19835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MRB58_19840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MRB58_19845	COG0328	RNA-DNA hybrid ribonuclease activity
MRB58_19855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MRB58_19860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MRB58_19875	COG2050	protein possibly involved in aromatic compounds catabolism
MRB58_19880	COG2514	catechol 2,3-dioxygenase activity
MRB58_19910	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MRB58_19915	COG0765	amino acid transport
MRB58_19920	COG0765	amino acid transport
MRB58_19935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_19945	COG0747	negative chemotaxis
MRB58_19980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MRB58_20020	COG0145	ligase activity
MRB58_20050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MRB58_20055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MRB58_20060	COG2080	2 iron, 2 sulfur cluster binding
MRB58_20075	COG2205	protein histidine kinase activity
MRB58_20075	COG5002	protein histidine kinase activity
MRB58_20075	COG0784	Response regulator, receiver
MRB58_20085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MRB58_20135	COG1294	oxidase, subunit
MRB58_20140	COG1271	oxidase subunit
MRB58_20160	COG2917	probably involved in intracellular septation
MRB58_20165	COG0740	serine-type endopeptidase activity
MRB58_20170	COG0656	L-ascorbic acid biosynthetic process
MRB58_20195	COG3920	Histidine kinase
MRB58_20210	COG2032	superoxide dismutase activity
MRB58_20215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MRB58_20215	COG0512	Glutamine amidotransferase of anthranilate synthase
MRB58_20260	COG1803	Methylglyoxal synthase
MRB58_20275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MRB58_20285	COG0330	HflC and HflK could
MRB58_20290	COG0330	HflC and HflK could
MRB58_20300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MRB58_20310	COG0432	Pfam Uncharacterised protein family UPF0047
MRB58_20325	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MRB58_20330	COG3639	organic phosphonate transmembrane transporter activity
MRB58_20350	COG2003	Belongs to the UPF0758 family
MRB58_20400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MRB58_20405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRB58_20410	COG0829	nickel cation binding
MRB58_20415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MRB58_20420	COG0804	urea catabolic process
MRB58_20425	COG0831	urea catabolic process
MRB58_20425	COG0832	Belongs to the urease beta subunit family
MRB58_20430	COG0830	nickel cation binding
MRB58_20440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MRB58_20455	COG1079	Belongs to the binding-protein-dependent transport system permease family
MRB58_20500	COG2124	cytochrome p450
MRB58_20505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MRB58_20515	COG3719	Belongs to the RNase T2 family
MRB58_20520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MRB58_20530	COG0583	DNA-binding transcription factor activity
MRB58_20535	COG2239	Acts as a magnesium transporter
MRB58_20550	COG0321	lipoyl(octanoyl) transferase activity
MRB58_20570	COG0463	Glycosyl transferase, family 2
MRB58_20595	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MRB58_20610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MRB58_20630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MRB58_20630	COG2755	lipolytic protein G-D-S-L family
MRB58_20640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MRB58_20660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MRB58_20665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MRB58_20675	COG0713	ATP synthesis coupled electron transport
MRB58_20690	COG1007	ATP synthesis coupled electron transport
MRB58_20705	COG0346	lactoylglutathione lyase activity
MRB58_20715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MRB58_20725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MRB58_20730	COG1335	isochorismatase
MRB58_20735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRB58_20775	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MRB58_20815	COG2072	flavoprotein involved in K transport
MRB58_20840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_20855	COG4336	lyase activity
MRB58_20875	COG4235	cytochrome complex assembly
MRB58_20880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MRB58_20885	COG1138	Cytochrome C-type biogenesis protein
MRB58_20890	COG3088	subunit of a heme lyase
MRB58_20900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MRB58_20905	COG0745	RESPONSE REGULATOR receiver
MRB58_20910	COG3850	Histidine kinase
MRB58_20910	COG0642	Histidine kinase
MRB58_20915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MRB58_20925	COG2205	protein histidine kinase activity
MRB58_20925	COG2202	Pas domain
MRB58_20930	COG0308	aminopeptidase N
MRB58_20935	COG1960	acyl-CoA dehydrogenase activity
MRB58_20960	COG4172	Belongs to the ABC transporter superfamily
MRB58_20965	COG0747	negative chemotaxis
MRB58_20970	COG0601	transmembrane transport
MRB58_20975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_20985	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MRB58_21000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MRB58_21005	COG1131	(ABC) transporter
MRB58_21010	COG0842	Transport permease protein
MRB58_21025	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MRB58_21040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MRB58_21050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MRB58_21060	COG0668	transmembrane transport
MRB58_21075	COG1360	Flagellar Motor Protein
MRB58_21090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MRB58_21095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MRB58_21100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MRB58_21105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MRB58_21125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MRB58_21130	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_21135	COG1338	Plays a role in the flagellum-specific transport system
MRB58_21145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MRB58_21155	COG1706	bacterial-type flagellum-dependent cell motility
MRB58_21165	COG4786	Flagellar basal body rod
MRB58_21170	COG1677	Flagellar hook-basal body complex protein FliE
MRB58_21175	COG1558	bacterial-type flagellum-dependent cell motility
MRB58_21180	COG1815	bacterial-type flagellum-dependent cell motility
MRB58_21185	COG0110	maltose O-acetyltransferase activity
MRB58_21190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MRB58_21195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MRB58_21200	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MRB58_21215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MRB58_21225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MRB58_21235	COG0477	Major facilitator Superfamily
MRB58_21240	COG0596	Alpha beta hydrolase
MRB58_21245	COG1819	glycosyl
MRB58_21250	COG1819	glycosyl
MRB58_21255	COG0736	holo-[acyl-carrier-protein] synthase activity
MRB58_21260	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_21280	COG3321	synthase
MRB58_21280	COG0604	alcohol dehydrogenase
MRB58_21285	COG0300	oxidoreductase activity
MRB58_21285	COG0318	PFAM AMP-dependent synthetase and ligase
MRB58_21285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MRB58_21285	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_21285	COG3321	synthase
MRB58_21295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRB58_21305	COG4786	Flagellar basal body rod
MRB58_21320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MRB58_21325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MRB58_21345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MRB58_21350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MRB58_21350	COG2111	Na H antiporter
MRB58_21355	COG2111	Na H antiporter
MRB58_21360	COG1006	Multisubunit Na H antiporter MnhC subunit
MRB58_21365	COG0651	ATP synthesis coupled electron transport
MRB58_21370	COG1863	multisubunit Na H antiporter MnhE subunit
MRB58_21375	COG2212	antiporter activity
MRB58_21380	COG1320	monovalent cation:proton antiporter activity
MRB58_21385	COG4957	zinc ion binding
MRB58_21400	COG2166	iron-sulfur cluster assembly
MRB58_21410	COG0028	Belongs to the TPP enzyme family
MRB58_21415	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_21420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MRB58_21445	COG1858	cytochrome C peroxidase
MRB58_21455	COG1940	carbohydrate kinase activity
MRB58_21460	COG4213	ABC transporter substrate-binding protein
MRB58_21465	COG4214	carbohydrate transport
MRB58_21470	COG1129	ABC transporter
MRB58_21480	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MRB58_21490	COG0287	Prephenate dehydrogenase
MRB58_21505	COG1129	ABC transporter
MRB58_21510	COG1172	Belongs to the binding-protein-dependent transport system permease family
MRB58_21520	COG1850	ribulose-bisphosphate carboxylase activity
MRB58_21530	COG2186	Transcriptional regulator
MRB58_21540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRB58_21550	COG1175	transmembrane transport
MRB58_21555	COG0395	ABC-type sugar transport system, permease component
MRB58_21560	COG3842	ATPase activity
MRB58_21570	COG2030	dehydratase
MRB58_21575	COG0625	glutathione transferase activity
MRB58_21600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MRB58_21630	COG0747	negative chemotaxis
MRB58_21645	COG0444	Belongs to the ABC transporter superfamily
MRB58_21650	COG4608	Belongs to the ABC transporter superfamily
MRB58_21670	COG3023	N-Acetylmuramoyl-L-alanine amidase
MRB58_21675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MRB58_21680	COG2267	carboxylic ester hydrolase activity
MRB58_21685	COG0071	Belongs to the small heat shock protein (HSP20) family
MRB58_21690	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
MRB58_21705	COG3220	belongs to the UPF0276 family
MRB58_21715	COG0583	DNA-binding transcription factor activity
MRB58_21720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MRB58_21725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MRB58_21730	COG3485	protocatechuate 3,4-dioxygenase
MRB58_21735	COG3485	protocatechuate 3,4-dioxygenase
MRB58_21745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_21760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MRB58_21780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MRB58_21785	COG0746	molybdenum cofactor guanylyltransferase activity
MRB58_21790	COG1763	Mo-molybdopterin cofactor biosynthetic process
MRB58_21795	COG0303	'Molybdopterin
MRB58_21800	COG2211	Major facilitator Superfamily
MRB58_21805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MRB58_21810	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MRB58_21820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MRB58_21825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MRB58_21835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MRB58_21840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MRB58_21850	COG0521	Mo-molybdopterin cofactor biosynthetic process
MRB58_21855	COG0281	malic enzyme
MRB58_21855	COG0280	phosphate acetyltransferase
MRB58_21880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MRB58_21920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MRB58_21925	COG1862	Preprotein translocase
MRB58_21930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MRB58_21940	COG3737	Protein of unknown function (DUF498/DUF598)
MRB58_21950	COG0519	Catalyzes the synthesis of GMP from XMP
MRB58_21950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MRB58_21955	COG1755	Isoprenylcysteine carboxyl methyltransferase
MRB58_21970	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_21975	COG2205	protein histidine kinase activity
MRB58_21990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MRB58_21995	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
MRB58_22005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRB58_22020	COG0444	Belongs to the ABC transporter superfamily
MRB58_22030	COG0747	negative chemotaxis
MRB58_22040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MRB58_22055	COG1573	uracil-dna glycosylase
MRB58_22060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MRB58_22065	COG0730	response to heat
MRB58_22070	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MRB58_22070	COG3264	Mechanosensitive ion channel
MRB58_22090	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MRB58_22105	COG1012	belongs to the aldehyde dehydrogenase family
MRB58_22115	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_22135	COG1492	cobalamin metabolic process
MRB58_22140	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MRB58_22150	COG0174	glutamine synthetase
MRB58_22155	COG0347	Belongs to the P(II) protein family
MRB58_22160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MRB58_22160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MRB58_22175	COG0544	peptidyl-prolyl cis-trans isomerase activity
MRB58_22180	COG0740	serine-type endopeptidase activity
MRB58_22185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MRB58_22200	COG0628	permease
MRB58_22205	COG1295	ribonuclease BN
MRB58_22210	COG3237	CsbD-like
MRB58_22215	COG3920	Histidine kinase
MRB58_22235	COG0784	Response regulator, receiver
MRB58_22255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MRB58_22260	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_22270	COG1028	Short-chain dehydrogenase reductase Sdr
MRB58_22275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_22280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MRB58_22305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MRB58_22310	COG1802	Transcriptional regulator
MRB58_22315	COG0431	NADPH-dependent FMN reductase
MRB58_22330	COG0187	DNA topoisomerase II activity
MRB58_22350	COG0129	dihydroxy-acid dehydratase activity
MRB58_22375	COG5507	3-demethylubiquinone-9 3-methyltransferase
MRB58_22395	COG0316	Belongs to the HesB IscA family
MRB58_22400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MRB58_22410	COG0018	arginyl-trna synthetase
MRB58_22420	COG1472	Belongs to the glycosyl hydrolase 3 family
MRB58_22425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MRB58_22430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MRB58_22435	COG3842	ATPase activity
MRB58_22440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MRB58_22445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MRB58_22450	COG0805	protein transport
MRB58_22455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MRB58_22465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MRB58_22470	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MRB58_22475	COG2945	thiolester hydrolase activity
MRB58_22480	COG1104	cysteine desulfurase activity
MRB58_22485	COG0719	Fe-S assembly protein
MRB58_22495	COG0396	ATPase activity
MRB58_22500	COG0719	Fe-S assembly protein
MRB58_22505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MRB58_22510	COG2151	metal-sulfur cluster biosynthetic enzyme
MRB58_22525	COG0513	Belongs to the DEAD box helicase family
MRB58_22530	COG0405	Gamma-glutamyltransferase
MRB58_22540	COG0047	phosphoribosylformylglycinamidine synthase activity
MRB58_22550	COG1280	lysine exporter protein (LysE YggA)
MRB58_22555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MRB58_22580	COG4166	transmembrane transport
MRB58_22605	COG0679	Auxin Efflux Carrier
MRB58_22610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MRB58_22620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRB58_22650	COG0084	hydrolase, TatD family'
MRB58_22655	COG0321	lipoyl(octanoyl) transferase activity
MRB58_22655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MRB58_22660	COG3956	TIGRFAM MazG family protein
MRB58_22665	COG1024	Enoyl-CoA hydratase
MRB58_22670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MRB58_22675	COG1923	regulation of RNA biosynthetic process
MRB58_22680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MRB58_22685	COG0569	domain protein
MRB58_22690	COG1794	racemase activity, acting on amino acids and derivatives
MRB58_22700	COG2204	response regulator
MRB58_22705	COG5000	phosphorelay sensor kinase activity
MRB58_22720	COG0022	dehydrogenase e1 component
MRB58_22720	COG0508	dehydrogenase complex catalyzes the overall conversion of
MRB58_22725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MRB58_22740	COG0752	glycyl-tRNA synthetase alpha subunit
MRB58_22750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MRB58_22760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MRB58_22770	COG3191	aminopeptidase activity
MRB58_22775	COG1115	amino acid carrier protein
MRB58_22795	COG1175	transmembrane transport
MRB58_22805	COG1472	Belongs to the glycosyl hydrolase 3 family
MRB58_22820	COG0484	heat shock protein binding
MRB58_22830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MRB58_22835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MRB58_22840	COG3706	GGDEF domain
MRB58_22850	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MRB58_22865	COG0804	urea catabolic process
MRB58_22890	COG0154	amidase activity
MRB58_22895	COG3734	2-keto-3-deoxy-galactonokinase
MRB58_22900	COG0129	dihydroxy-acid dehydratase activity
MRB58_22905	COG1902	pentaerythritol trinitrate reductase activity
MRB58_22910	COG2271	Major facilitator Superfamily
MRB58_22920	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
MRB58_22945	COG1132	(ABC) transporter
MRB58_23035	COG1192	Involved in chromosome partitioning
MRB58_23105	COG0431	NADPH-dependent FMN reductase
MRB58_23110	COG0798	PFAM Bile acid sodium symporter
MRB58_23120	COG0640	Transcriptional regulator
MRB58_23140	COG2204	response regulator
MRB58_23165	COG2132	Multicopper oxidase
MRB58_23170	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_23180	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_23180	COG1388	LysM domain
MRB58_23195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MRB58_23195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MRB58_23235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MRB58_23245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MRB58_23255	COG0713	ATP synthesis coupled electron transport
MRB58_23265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MRB58_23270	COG1007	ATP synthesis coupled electron transport
MRB58_23285	COG3794	PFAM blue (type 1) copper domain protein
MRB58_23310	COG3436	PFAM IS66 Orf2 family protein
MRB58_23315	COG4372	Transposase
MRB58_23340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MRB58_23345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MRB58_23370	COG0785	Cytochrome C biogenesis protein
MRB58_23390	COG4227	nucleotidyltransferase activity
MRB58_23420	COG3843	relaxase mobilization nuclease domain protein
MRB58_23425	COG3505	Type IV secretory pathway VirD4
MRB58_23455	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
MRB58_23490	COG3451	type IV secretory pathway VirB4
MRB58_23505	COG0741	lytic transglycosylase activity
MRB58_23530	COG1376	ErfK ybiS ycfS ynhG family protein
MRB58_23535	COG0739	heme binding
MRB58_23545	COG0789	Transcriptional regulator
MRB58_23550	COG1999	signal sequence binding
MRB58_23560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MRB58_23560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MRB58_23570	COG1999	signal sequence binding
MRB58_23575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MRB58_23580	COG1914	H( )-stimulated, divalent metal cation uptake system
MRB58_23605	COG1999	signal sequence binding
MRB58_23640	COG0741	lytic transglycosylase activity
MRB58_23685	COG0726	polysaccharide deacetylase
MRB58_23715	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_23725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MRB58_23755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MRB58_23770	COG3473	Maleate cis-trans isomerase
MRB58_23795	COG0583	DNA-binding transcription factor activity
MRB58_23805	COG1126	abc transporter atp-binding protein
MRB58_23810	COG0765	amino acid transport
MRB58_23815	COG4597	amino acid ABC transporter
MRB58_23820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MRB58_23835	COG3706	GGDEF domain
MRB58_23845	COG4166	transmembrane transport
MRB58_23850	COG0747	negative chemotaxis
MRB58_23860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_23870	COG1215	transferase activity, transferring glycosyl groups
MRB58_23905	COG1215	transferase activity, transferring glycosyl groups
MRB58_23950	COG0110	maltose O-acetyltransferase activity
MRB58_23960	COG0438	transferase activity, transferring glycosyl groups
MRB58_24030	COG1215	transferase activity, transferring glycosyl groups
MRB58_24035	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MRB58_24085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MRB58_24100	COG1024	Enoyl-CoA hydratase
MRB58_24100	COG1250	3-hydroxyacyl-CoA dehydrogenase
MRB58_24125	COG0583	DNA-binding transcription factor activity
MRB58_24145	COG1309	transcriptional regulator
MRB58_24160	COG0242	peptide deformylase activity
MRB58_24165	COG0656	L-ascorbic acid biosynthetic process
MRB58_24170	COG4177	L-phenylalanine transmembrane transporter activity
MRB58_24175	COG0559	Belongs to the binding-protein-dependent transport system permease family
MRB58_24180	COG0410	ABC transporter
MRB58_24190	COG2186	Transcriptional regulator
MRB58_24215	COG4948	Mandelate Racemase Muconate Lactonizing
MRB58_24220	COG0473	3-isopropylmalate dehydrogenase activity
MRB58_24240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRB58_24245	COG1802	Transcriptional regulator
MRB58_24270	COG0747	negative chemotaxis
MRB58_24275	COG0601	transmembrane transport
MRB58_24280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MRB58_24285	COG0444	Belongs to the ABC transporter superfamily
MRB58_24310	COG1475	DNA binding
MRB58_24315	COG1192	Involved in chromosome partitioning
MRB58_24320	COG0640	Transcriptional regulator
MRB58_24325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MRB58_24335	COG1116	anion transmembrane transporter activity
MRB58_24340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MRB58_24360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MRB58_24365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MRB58_24385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MRB58_24395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MRB58_24405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MRB58_24410	COG0784	Response regulator, receiver
MRB58_24410	COG4191	Histidine kinase
MRB58_24415	COG5002	protein histidine kinase activity
MRB58_24415	COG3447	MASE1 domain protein
MRB58_24415	COG5001	Diguanylate cyclase
MRB58_24440	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MRB58_24475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MRB58_24495	COG1088	dTDP-glucose 4,6-dehydratase activity
MRB58_24520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MRB58_24525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MRB58_24530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MRB58_24545	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MRB58_24560	COG1083	cytidylyl-transferase
MRB58_24565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MRB58_24590	COG1192	Involved in chromosome partitioning
MRB58_24595	COG1475	DNA binding
MRB58_24615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MRB58_24620	COG4251	negative regulation of phosphorylation
MRB58_24630	COG0038	chloride channel
MRB58_24635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MRB58_24655	COG0811	peptide transport
MRB58_24740	COG3181	Tripartite tricarboxylate transporter family receptor
MRB58_24765	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MRB58_24795	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation